tetradecanoylphorbol acetate has been researched along with Metastase in 95 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (15.79) | 18.7374 |
| 1990's | 35 (36.84) | 18.2507 |
| 2000's | 20 (21.05) | 29.6817 |
| 2010's | 23 (24.21) | 24.3611 |
| 2020's | 2 (2.11) | 2.80 |
| Authors | Studies |
|---|---|
| Baek, J; Kim, S; Lee, KS; Nam, GS; Nam, KS | 1 |
| Cho, Y; Jeon, SD; Kim, C; Kim, KY; Kim, MG; Lee, HS; Yoon, J; Yoon, MJ | 1 |
| Choi, JH; Chung, YC; Han, EH; Hwang, YP; Jeong, HG; Jin, SW; Kang, KW; Kim, HG; Kim, SK; Lee, GH | 1 |
| Chen, MK; Chuang, CY; Ho, HY; Hsieh, YH; Hsin, CH; Lin, CW; Lin, HP; Wu, BC; Yang, SF | 1 |
| Lee, KS; Nam, KS; Shin, JS | 1 |
| Bamidele, AO; Clift, IC; Hedin, KE; Kremer, KN; Rodriguez-Ramirez, C | 1 |
| Chen, X; Tan, W; Wang, Y; Zhong, Z | 1 |
| Berry, P; Maitland, NJ; Noble, A; Otsuka, M; Rumsby, MG; Schmitt, J | 1 |
| Chen, CT; Chen, MK; Chou, MY; Chuang, YT; Hsieh, YH; Lin, CW; Lin, FY; Tang, CH; Yang, SF | 1 |
| Kimura, Y; Sumiyoshi, M | 1 |
| Chien, MH; Ho, HY; Hsieh, YH; Lin, CW; Reiter, RJ; Su, SC; Yang, SF | 1 |
| Im, M; Kim, A; Ma, JY | 1 |
| Chen, YW; Fodstad, O; Tekle, C | 1 |
| Huber, O; Jackson, P; Kramer, TS; Rowe, A; Weiske, J | 1 |
| Cui, J; Gao, D; Guo, K; Kang, X; Li, Y; Liu, Y; Sun, L | 1 |
| Azzarone, B; Caignard, A; Charpentier, B; Chouaib, S; Devocelle, A; Eid, P; Fabbi, M; Ferrini, S; Giron-Michel, J; Giuliani, M; Gu, Y; Khawam, K; Ludwig, A; Perier, A | 1 |
| Camilli, TC; Fiori, JL; Frank, BP; French, AD; Indig, FE; Leotlela, PD; O'Connell, MP; Subaran, S; Taub, DD; Weeraratna, AT | 1 |
| Kalinovsky, T; Monterrey, JC; Niedzwiecki, A; Rath, M; Roomi, MW | 1 |
| Choi, CY; Choi, JH; Choi, JM; Chung, YC; Han, EH; Hwang, YP; Jeong, HG; Seo, JK | 1 |
| Loilome, W; Miwa, M; Namwat, N; Puapairoj, A; Saya, H; Sugihara, E; Takahashi, E; Techasen, A; Yongvanit, P | 1 |
| Chen, PS; Chien, ST; Lee, JH; Shih, YW; Wu, SH; Yin, LT | 1 |
| Goding, CR; Leaner, VD; Mowla, S; Pinnock, R; Prince, S | 1 |
| Kesselring, R; Pries, R; Thiel, A; Wollenberg, B | 1 |
| Boe, A; Bottero, L; Carè, A; Colombo, MP; Di Virgilio, A; Errico, MC; Felicetti, F; Mattia, G; Petrini, M; Romania, P; Segnalini, P; Tomasello, L | 1 |
| Lee, J; Lim, KT | 1 |
| Aoi, J; Araki, K; Endo, M; Hirakawa, S; Horiguchi, H; Ihn, H; Ito, T; Jinnin, M; Kadomatsu, T; Miyata, K; Nakano, M; Odagiri, H; Ogata, A; Oike, Y; Yano, M | 1 |
| Liao, YF; Rao, YK; Tzeng, YM | 1 |
| Kim, Y; Kim, YH; Lee, SJ; Park, SY | 1 |
| Hwang, BM; Hwang, JK; Jung, SH; Kim, BS; Kim, JM; Kim, JS; Kwon, KB; Lee, SH; Lee, SJ; Lee, YR; Noh, EM; You, YO; Youn, HJ | 1 |
| Ibrahim, S; Levin, B; Meruelo, D; Pellicer, A; Suzme, R; Tseng, JC | 1 |
| Chen, L; Jin, X; Li, H; Mao, J; Wang, L; Xu, B; Yuan, J; Zhang, H; Zhu, J | 1 |
| Beltrán, L; Bol, DK; Carbajal, S; DiGiovanni, J; Jiang, J; Kiguchi, K; Matsumoto, T; Rosenberg, MP; Ruffino, L | 1 |
| Hwang, BD; Jung, YJ; Kim, TD; Lee, BH; Lee, TG; Li, G; Lim, K; Park, HD; Song, IS; Yoon, WH | 1 |
| Baj, G; Cannas, M; Renò, F; Surico, N | 1 |
| Aggarwal, BB; Shishodia, S | 1 |
| Toker, A; Yiu, GK | 1 |
| Bowman, L; Castranova, V; Ding, M; Feng, R; Jiang, BH; Lu, Y; Qian, Y; Shi, X; Wang, SY | 1 |
| Foda, H; Hymowitz, M; Montana, S; Rollo, EE; Schmidt, CE; Zucker, S | 1 |
| Suyama, H; Ushijima, N; Yamamoto, N | 1 |
| Bockman, RS; Honn, KV; Marnett, LJ | 1 |
| Iyer, N; King, L; Krebs, C; Kucera, LS; Waite, BM | 1 |
| Hart, IR; Talmadge, JE | 1 |
| Varani, J | 1 |
| Irimura, T; Kakiuchi, T; Koike, C; Okada, S; Oku, N; Tsukada, H; Watanabe, M | 1 |
| Hamada, J; Hosokawa, M; Imamura, M; Kobayashi, M; Li, YQ; Okada, F; Shinobu, N; Takeichi, N | 1 |
| Bennett, DC; Devlin, L; Hart, IR; Holmes, A | 1 |
| MacLarkey, WR; Orr, FW; Shaughnessy, SG; Soares, FA | 1 |
| Chen, ZH; Gopalakrishna, R; Gundimeda, U | 1 |
| Herbert, JM | 1 |
| Huijzer, JC; McFarland, M; Meadows, GG; Niles, RM | 1 |
| Davidson, NE; Kennedy, MJ | 1 |
| Cano, A; Conti, CJ; Duran, H; Jorcano, JL; Larcher, F; Murillas, R; Quintanilla, M; Robles, AI | 1 |
| Honn, KV; Tang, DG | 1 |
| Damtew, B; Spagnuolo, PJ | 1 |
| Fenner, MH; Isselbacher, KJ; Jain, RK; Munn, LL; Shioda, T | 1 |
| Honn, KV; Trikha, M | 1 |
| Kubens, BS; Nikolai, G; Zänker, KS | 1 |
| Fujita, N; Morinaga, Y; Nakagawa, T; Oh-hara, T; Tsuruo, T; Yamada, M; Zhang, Y | 1 |
| Jung, B; Kerbel, RS; Kobayashi, H; Landthaler, M; McClelland, M; Stolz, W; Vogt, T; Welsh, J | 1 |
| Linder, S; Ljungdahl, S; Shoshan, MC; Swedenborg, J; Zhou, JN | 1 |
| Gawrychowski, K; Janik, P; Szaniawska, B | 1 |
| Lavrovskiĭ, VA; Subkhankulova, TN | 1 |
| Comolli, R; La Porta, CA | 1 |
| Carey, I; Noti, JD; Ways, DK; Williams, CL | 1 |
| Comolli, R; La Porta, CA; Porro, D | 1 |
| Bowden, GT; Broome Powell, M; Gause, PR; Gregus, J; Hyman, P; Lluria-Prevatt, M; Nagle, R | 1 |
| Inoue, T; Koono, M; Nabeshima, K; Shimao, Y | 1 |
| Hudson, MA; McReynold, LM | 1 |
| Akita, H; Hashimoto, Y; Iizuka, A; Ikeda, K; Kohri, K; Nakanishi, M | 1 |
| Comolli, R; Di Dio, A; La Porta, CA; Porro, D | 1 |
| Bouchier-Hayes, D; Condron, C; Redmond, HP; Wang, JH; Wu, QD | 1 |
| Chen, HL; Liu, F; Qi, HL | 1 |
| He, C; Li, H; Zheng, J | 1 |
| Alvarez, E; Aulicino, P; Ernst, G; García, M; Hajos, SE; Lopes, EC; Vanzulli, S | 1 |
| Beaumont, J; Blackburn, GM; Brown, J; Doughty, S; Mac Neil, S; Wagner, M; Wowk, I | 1 |
| Bagash, JM; Coogan, M; Lozano, Y; Young, ME; Young, MR | 1 |
| Bonham, K; Bowden, GT; Krieg, P; Ostrowski, LE | 1 |
| Aldaz, CM; Chiba, M; Conti, CJ; Klein-Szanto, AJ | 1 |
| Baldwin, GC; Economou, J; Gasson, JC; Golde, DW; Widhopf, GF | 1 |
| Bereta, J; Bereta, M; Cohen, MC; Cohen, S; Zaifert, K | 1 |
| Aliño, SF; Almena, A; Barbero, MC; Garcia, M | 1 |
| Buckmeier, JA; Graham, M; Meyskens, FL; Yamanishi, DT | 1 |
| Collier, IE; Frisch, SM; Genrich, LT; Goldberg, GI; Martin, G; Reich, R | 1 |
| Chambers, AF; Craig, AM; Denhardt, DT; Edwards, DR; Guo, XJ; Murphy, LC; Parfett, CL; Reid, RE; Waterhouse, P | 1 |
| Kerbel, RS; Korczak, B; Whale, C | 1 |
| Conn, KG; Knudsen, KA | 1 |
| Ayaki, H; Enomoto, T | 1 |
| Biempica, L; Nakagawa, S; Takahashi, S; Zeydel, M | 1 |
| Pohl, J; Radler-Pohl, A; Schirrmacher, V | 1 |
| Goode, NT; Hart, IR; Ormerod, EJ | 1 |
| Hart, DA; Smith, R | 1 |
| Chow, DA; Sandstrom, PA | 1 |
| Barsky, SH; Gopalakrishna, R | 1 |
| Mashiba, H; Matsunaga, K | 1 |
| Takahashi, K; Takenaga, K | 1 |
8 review(s) available for tetradecanoylphorbol acetate and Metastase
| Article | Year |
|---|---|
Prostaglandins and cancer: a review of tumor initiation through tumor metastasis.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Cyclooxygenase Inhibitors; DNA; Epoprostenol; Female; Hematopoietic Stem Cells; Humans; Kidney; Male; Mutagens; Neoplasm Metastasis; Neoplasms; Oxidation-Reduction; Prostaglandins; Prostaglandins D; Prostaglandins E; Prostaglandins F; Skin; Tetradecanoylphorbol Acetate; Thromboxane A2 | 1981 |
Protein kinase C: a key factor in the regulation of tumor cell adhesion to the endothelium.
Topics: Amino Acid Sequence; Animals; Cell Adhesion; Cell Division; Cell Line; Endothelium, Vascular; Enzyme Activation; Growth Substances; Humans; Integrins; Molecular Sequence Data; Neoplasm Metastasis; Protein Kinase C; Receptors, Cytoadhesin; Tetradecanoylphorbol Acetate | 1993 |
Protein kinase C and breast cancer.
Topics: Breast Neoplasms; Drug Resistance, Multiple; ErbB Receptors; Female; Humans; Neoplasm Metastasis; Protein Kinase C; Receptors, Estrogen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Adhesion molecules and tumor cell-vasculature interactions: modulation by bioactive lipid molecules.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Cell Adhesion; Cell Adhesion Molecules; Cytoskeletal Proteins; Endothelium, Vascular; Enzyme Activation; Extracellular Matrix; Female; Humans; Isoenzymes; Male; Mice; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Neoplasms, Experimental; Neoplastic Cells, Circulating; Organ Specificity; Protein Kinase C; Tetradecanoylphorbol Acetate; Up-Regulation | 1996 |
Role of 12-lipoxygenase and protein kinase C in modulating the activation state of the integrin alpha IIb beta 3 on human tumor cells.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonate 12-Lipoxygenase; Cell Adhesion; Cell Movement; Disease Progression; Enzyme Activation; Extracellular Matrix; Humans; Models, Biological; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Differential gene expression during tumor promotion and progression in the mouse skin model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Actins; Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cocarcinogenesis; DNA; Gene Expression Regulation, Neoplastic; Matrix Metalloproteinase 3; Metalloendopeptidases; Methylnitronitrosoguanidine; Mice; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms, Multiple Primary; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ubiquitins | 1991 |
[Novel non-tumorigenic cell variants showing potentially different susceptibility to v-src induced metastasis].
Topics: Animals; Cell Line, Transformed; Genetic Variation; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplasm Transplantation; Oncogenes; Tetradecanoylphorbol Acetate | 1989 |
A model to account for the effects of oncogenes, TPA, and retinoic acid on the regulation of genes involved in metastasis.
Topics: Animals; Gene Expression Regulation; Models, Theoretical; Neoplasm Metastasis; Oncogenes; Tetradecanoylphorbol Acetate; Transcription Factors; Transfection; Tretinoin | 1988 |
87 other study(ies) available for tetradecanoylphorbol acetate and Metastase
| Article | Year |
|---|---|
Inhibition of TPA‑induced metastatic potential by morin hydrate in MCF‑7 human breast cancer cells via the Akt/GSK‑3β/c‑Fos signaling pathway.
Topics: Breast Neoplasms; Cell Movement; Cell Survival; Flavonoids; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3 beta; Humans; MCF-7 Cells; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fos; Signal Transduction; Tetradecanoylphorbol Acetate | 2020 |
A JUN N-terminal kinase inhibitor induces ectodomain shedding of the cancer-associated membrane protease Prss14/epithin via protein kinase CβII.
Topics: Anthracenes; Cell Line, Tumor; Humans; MAP Kinase Kinase 4; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Protein Kinase C beta; Protein Kinase Inhibitors; Protein Transport; Serine Endopeptidases; Signal Transduction; Tetradecanoylphorbol Acetate | 2020 |
Suppression of PMA-induced human fibrosarcoma HT-1080 invasion and metastasis by kahweol via inhibiting Akt/JNK1/2/p38 MAPK signal pathway and NF-κB dependent transcriptional activities.
Topics: Cell Line, Tumor; Coffee; Diterpenes; Fibrosarcoma; Humans; MAP Kinase Signaling System; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; Tetradecanoylphorbol Acetate; Transcription, Genetic | 2019 |
Selaginella tamariscina extract suppresses TPA-induced invasion and metastasis through inhibition of MMP-9 in human nasopharyngeal carcinoma HONE-1 cells.
Topics: Carcinoma; Cell Line, Tumor; Cell Movement; Cell Survival; Humans; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mitogen-Activated Protein Kinase Kinases; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Plant Extracts; RNA, Messenger; Selaginellaceae; Signal Transduction; Tetradecanoylphorbol Acetate; Wound Healing | 2013 |
Starfish polysaccharides downregulate metastatic activity through the MAPK signaling pathway in MCF-7 human breast cancer cells.
Topics: Animals; Aromatase; Breast Neoplasms; Cell Movement; Cyclooxygenase 2; Down-Regulation; Female; Humans; I-kappa B Proteins; MAP Kinase Signaling System; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Metastasis; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Polysaccharides; Starfish; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinases; Transcription, Genetic | 2013 |
β-Arrestin1 and distinct CXCR4 structures are required for stromal derived factor-1 to downregulate CXCR4 cell-surface levels in neuroblastoma.
Topics: Arrestins; beta-Arrestins; Cell Line, Tumor; Cell Membrane; Chemokine CXCL12; Endocytosis; G-Protein-Coupled Receptor Kinase 2; GTP-Binding Proteins; Humans; Neoplasm Metastasis; Neuroblastoma; Pertussis Toxin; Phosphorylation; Protein Kinase C; Receptors, CXCR4; Tetradecanoylphorbol Acetate; Type C Phospholipases | 2014 |
Furanodiene, a natural small molecule suppresses metastatic breast cancer cell migration and invasion in vitro.
Topics: Antineoplastic Agents; Biological Products; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Furans; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 2-Ring; Humans; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Metastasis; Tetradecanoylphorbol Acetate | 2014 |
Phorbol ester stimulates ethanolamine release from the metastatic basal prostate cancer cell line PC3 but not from prostate epithelial cell lines LNCaP and P4E6.
Topics: Cell Line; Cell Line, Tumor; Enzyme Activation; Epithelial Cells; Ethanolamine; Humans; Intercellular Signaling Peptides and Proteins; Male; Neoplasm Metastasis; Peptides; Phospholipase D; Prostate; Prostatic Neoplasms; Tetradecanoylphorbol Acetate; Wasp Venoms | 2014 |
Resveratrol suppresses TPA-induced matrix metalloproteinase-9 expression through the inhibition of MAPK pathways in oral cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Survival; Down-Regulation; Enzyme Activation; Head and Neck Neoplasms; Humans; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mouth Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Resveratrol; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Stilbenes; Tetradecanoylphorbol Acetate; Tongue Neoplasms | 2015 |
Antitumor and antimetastatic actions of dihydroxycoumarins (esculetin or fraxetin) through the inhibition of M2 macrophage differentiation in tumor-associated macrophages and/or G1 arrest in tumor cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Body Weight; Cell Differentiation; Cell Line, Tumor; Cell Polarity; Cell Proliferation; Chemokine CCL2; Coumarins; Cyclin-Dependent Kinase 4; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Interleukin-10; Macrophage Activation; Macrophages; Male; Matrix Metalloproteinase 2; Mice; Neoplasm Metastasis; Osteosarcoma; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta1; Umbelliferones; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2015 |
Melatonin suppresses TPA-induced metastasis by downregulating matrix metalloproteinase-9 expression through JNK/SP-1 signaling in nasopharyngeal carcinoma.
Topics: Carcinoma; Cell Line, Tumor; Down-Regulation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Kinase 4; Matrix Metalloproteinase 9; Melatonin; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neoplasm Proteins; Signal Transduction; Sp1 Transcription Factor; Tetradecanoylphorbol Acetate | 2016 |
Ethanol extract of baked Gardeniae Fructus exhibits in vitro and in vivo anti-metastatic and anti-angiogenic activities in malignant cancer cells: Role of suppression of the NF-κB and HIF-1α pathways.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Gardenia; Human Umbilical Vein Endothelial Cells; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; Matrix Metalloproteinase 13; Matrix Metalloproteinase 9; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neovascularization, Pathologic; Plant Extracts; Tetradecanoylphorbol Acetate; Transcription Factor RelA | 2016 |
The immunoregulatory protein human B7H3 is a tumor-associated antigen that regulates tumor cell migration and invasion.
Topics: Antigens, CD; Antigens, Neoplasm; Antiviral Agents; B7 Antigens; Binding, Competitive; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Collagen; Drug Combinations; Enzyme-Linked Immunosorbent Assay; Fibronectins; Flow Cytometry; Glycosylation; Humans; Immunoprecipitation; Laminin; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Proteoglycans; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tunicamycin | 2008 |
Phorbol ester enhances KAI1 transcription by recruiting Tip60/Pontin complexes.
Topics: Active Transport, Cell Nucleus; ATPases Associated with Diverse Cellular Activities; Carcinogens; Carrier Proteins; Cell Line, Tumor; DNA Helicases; Gene Expression Regulation, Neoplastic; Histone Acetyltransferases; Histones; Humans; Kangai-1 Protein; Lysine Acetyltransferase 5; Neoplasm Metastasis; p38 Mitogen-Activated Protein Kinases; Phorbol Esters; Tetradecanoylphorbol Acetate; Transcription, Genetic | 2008 |
Role of PKCbeta in hepatocellular carcinoma cells migration and invasion in vitro: a potential therapeutic target.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Humans; Indoles; Liver Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Protein Kinase C; Protein Kinase C beta; RNA Interference; Tetradecanoylphorbol Acetate | 2009 |
Human renal cancer cells express a novel membrane-bound interleukin-15 that induces, in response to the soluble interleukin-15 receptor alpha chain, epithelial-to-mesenchymal transition.
Topics: Antibodies, Monoclonal; Carcinoma, Renal Cell; Carcinoma, Small Cell; Cell Differentiation; Cell Line, Tumor; Cell Membrane; Epithelial Cells; Flow Cytometry; Humans; Immunotherapy; Interleukin-15; Kidney Neoplasms; Lung Neoplasms; Mesoderm; Neoplasm Metastasis; Receptors, Interleukin-15; Sodium Acetate; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2009 |
PKC and PKA phosphorylation affect the subcellular localization of claudin-1 in melanoma cells.
Topics: Biological Transport; Cell Line, Tumor; Cell Nucleus; Claudin-1; Computer Simulation; Cyclic AMP-Dependent Protein Kinases; Cytoplasm; Enzyme Activation; Genetic Vectors; Humans; Immunohistochemistry; Matrix Metalloproteinase 2; Melanoma; Membrane Proteins; Mutagenesis, Site-Directed; Neoplasm Invasiveness; Neoplasm Metastasis; Nuclear Localization Signals; Phosphorylation; Protein Kinase C; Subcellular Fractions; Tetradecanoylphorbol Acetate; Transfection | 2009 |
Modulation of MMP-2 and MMP-9 by cytokines, mitogens and inhibitors in lung cancer and malignant mesothelioma cell lines.
Topics: Antineoplastic Agents; Cell Line, Tumor; Culture Media; Cytokines; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Lipopolysaccharides; Lung Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mesothelioma; Neoplasm Metastasis; Tetradecanoylphorbol Acetate; Time Factors | 2009 |
Suppression of PMA-induced tumor cell invasion and metastasis by aqueous extract isolated from Prunella vulgaris via the inhibition of NF-kappaB-dependent MMP-9 expression.
Topics: Administration, Oral; Animals; Cell Movement; Cell Nucleus; Lung Neoplasms; Matrix Metalloproteinase 9; Melanoma; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; Phosphorylation; Plant Extracts; Prunella; Tetradecanoylphorbol Acetate; Translocation, Genetic; Xenograft Model Antitumor Assays | 2010 |
Myristoylated alanine-rich C kinase substrate phosphorylation promotes cholangiocarcinoma cell migration and metastasis via the protein kinase C-dependent pathway.
Topics: Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Movement; Cholangiocarcinoma; Cricetinae; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Neoplasm Metastasis; Phosphorylation; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate | 2010 |
Alpha-mangostin suppresses phorbol 12-myristate 13-acetate-induced MMP-2/MMP-9 expressions via alphavbeta3 integrin/FAK/ERK and NF-kappaB signaling pathway in human lung adenocarcinoma A549 cells.
Topics: Adenocarcinoma; Blotting, Western; Cell Line, Tumor; Cell Movement; Focal Adhesion Kinase 1; Humans; Integrin alphaVbeta3; Lung Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Metastasis; NF-kappa B; RNA, Small Interfering; Signal Transduction; Tetradecanoylphorbol Acetate; Xanthones | 2010 |
PMA-induced up-regulation of TBX3 is mediated by AP-1 and contributes to breast cancer cell migration.
Topics: Breast Neoplasms; Cell Movement; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Metastasis; Response Elements; RNA, Messenger; T-Box Domain Proteins; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Up-Regulation | 2011 |
The number of CD161 positive Th17 cells are decreased in head and neck cancer patients.
Topics: Aged; Brefeldin A; Carcinoma, Squamous Cell; Culture Media, Conditioned; Head and Neck Neoplasms; Humans; Ionomycin; Leukocytes, Mononuclear; Lymph Nodes; Lymphocyte Activation; Middle Aged; Neoplasm Metastasis; NK Cell Lectin-Like Receptor Subfamily B; Tetradecanoylphorbol Acetate; Th17 Cells | 2011 |
Constitutive activation of the ETS-1-miR-222 circuitry in metastatic melanoma.
Topics: Animals; Cell Line, Tumor; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Melanocytes; Melanoma; Mice; Mice, Nude; MicroRNAs; Neoplasm Metastasis; Phosphorylation; Phosphothreonine; Proto-Oncogene Mas; Proto-Oncogene Protein c-ets-1; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic | 2011 |
Inhibitory effect of phytoglycoprotein (38 kDa) on expression of matrix metalloproteinase-9 in 12-O-tetradecanoylphorbol-13-acetate-treated HepG2cells.
Topics: Antineoplastic Agents, Phytogenic; Cell Movement; Electrophoretic Mobility Shift Assay; Glycoproteins; Hep G2 Cells; Humans; Immunoblotting; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; Reactive Oxygen Species; Signal Transduction; Styrax; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2011 |
Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis.
Topics: Angiopoietin-Like Protein 2; Angiopoietin-like Proteins; Angiopoietins; Animals; Carcinogens; Carcinoma, Squamous Cell; Epithelial-Mesenchymal Transition; Female; Gene Expression; Immunoblotting; Immunohistochemistry; Inflammation; Inflammation Mediators; Kaplan-Meier Estimate; Lymph Nodes; Lymphangiogenesis; Male; Mice; Mice, Knockout; Mice, Transgenic; Neoplasm Metastasis; Neovascularization, Pathologic; Reverse Transcriptase Polymerase Chain Reaction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Aqueous extract of Anisomeles indica and its purified compound exerts anti-metastatic activity through inhibition of NF-κB/AP-1-dependent MMP-9 activation in human breast cancer MCF-7 cells.
Topics: Base Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Movement; DNA Primers; Female; Humans; Lamiaceae; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; Plant Extracts; Reverse Transcriptase Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Water | 2012 |
Frondoside A has an anti-invasive effect by inhibiting TPA-induced MMP-9 activation via NF-κB and AP-1 signaling in human breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Female; Glycosides; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Triterpenes | 2012 |
Curcumin suppresses the TPA-induced invasion through inhibition of PKCα-dependent MMP-expression in MCF-7 human breast cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Biological Transport; Breast Neoplasms; Cell Movement; Curcuma; Curcumin; Female; Humans; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Metastasis; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phytotherapy; Plant Extracts; Protein Kinase C-alpha; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2012 |
Sindbis viral vectors target hematopoietic malignant cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Female; Gene Expression Regulation, Neoplastic; Genetic Therapy; Genetic Vectors; Hematologic Neoplasms; Humans; Injections, Intraperitoneal; Jurkat Cells; Male; Mice; Mice, Inbred AKR; Mice, Inbred C3H; Mice, Transgenic; Neoplasm Metastasis; Neoplasms, Experimental; Oncolytic Virotherapy; Receptors, Laminin; Sindbis Virus; Tetradecanoylphorbol Acetate | 2012 |
Tamoxifen inhibits migration of estrogen receptor-negative hepatocellular carcinoma cells by blocking the swelling-activated chloride current.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Size; Chloride Channels; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Neoplasm Metastasis; Receptors, Estrogen; RNA, Small Interfering; Tamoxifen; Tetradecanoylphorbol Acetate | 2013 |
Targeted expression of c-Src in epidermal basal cells leads to enhanced skin tumor promotion, malignant progression, and metastasis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Amino Acid Sequence; Animals; Carcinoma, Squamous Cell; CSK Tyrosine-Protein Kinase; Female; Male; Mice; Mice, Transgenic; Molecular Sequence Data; Neoplasm Metastasis; Protein-Tyrosine Kinases; Skin; Skin Neoplasms; src-Family Kinases; Tetradecanoylphorbol Acetate | 2003 |
Differential regulation of vimentin mRNA by 12-O-tetradecanoylphorbol 13-acetate and all-trans-retinoic acid correlates with motility of Hep 3B human hepatocellular carcinoma cells.
Topics: Carcinoma, Hepatocellular; Cell Movement; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Matrix Metalloproteinases; Neoplasm Metastasis; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator; Vimentin | 2004 |
Exogenous prostaglandin E2 inhibits TPA induced matrix metalloproteinase-9 production in MCF-7 cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Collagen; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Drug Combinations; Enzyme Activation; Enzyme Induction; Humans; Laminin; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Metastasis; Proteoglycans; Receptors, Prostaglandin; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Tetradecanoylphorbol Acetate | 2004 |
Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis.
Topics: Active Transport, Cell Nucleus; Apoptosis; Blotting, Western; Cell Line; Cell Line, Tumor; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation; Genes, Reporter; Humans; I-kappa B Proteins; Inflammation; Interleukin-1; Isoenzymes; Jurkat Cells; Luciferases; Membrane Proteins; Models, Chemical; Neoplasm Metastasis; NF-kappa B; NF-KappaB Inhibitor alpha; Okadaic Acid; Phosphorylation; Poly(ADP-ribose) Polymerases; Pregnenediones; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Protein Structure, Tertiary; Temperature; Tetradecanoylphorbol Acetate; Transcription, Genetic | 2004 |
NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2.
Topics: Breast Neoplasms; Cell Line, Tumor; Collagen; Cyclooxygenase 2; Cyclosporine; Dinoprostone; Drug Combinations; Humans; Ionomycin; Ionophores; Laminin; Neoplasm Invasiveness; Neoplasm Metastasis; NFATC Transcription Factors; Proteoglycans; RNA, Small Interfering; Tetradecanoylphorbol Acetate | 2006 |
Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity.
Topics: Animals; Anthocyanins; Anticarcinogenic Agents; Antineoplastic Agents; Benz(a)Anthracenes; Carcinogens; Cell Line, Tumor; Fruit; Glucosides; Humans; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Metastasis; Plant Extracts; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcriptional Activation; Ultraviolet Rays; Wound Healing | 2006 |
Neutrophil activator of matrix metalloproteinase-2 (NAM).
Topics: Adult; Amides; Calcimycin; Cathepsin G; Cathepsins; Cells, Cultured; Culture Media, Conditioned; Endothelium, Vascular; Enzyme Activation; Enzyme Precursors; Humans; Inflammation; Ionomycin; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Neoplasm Metastasis; Neutrophils; Oligopeptides; Pancreatic Elastase; Phenylalanine; Protease Inhibitors; Proteins; RNA, Messenger; Serine Endopeptidases; Substrate Specificity; Tetradecanoylphorbol Acetate; Thiophenes; Tissue Inhibitor of Metalloproteinase-2; Umbilical Veins | 2006 |
Immunotherapy of metastatic breast cancer patients with vitamin D-binding protein-derived macrophage activating factor (GcMAF).
Topics: Adult; Aged; alpha-N-Acetylgalactosaminidase; Breast Neoplasms; Female; Glycosylation; Humans; Immunotherapy; Macrophage Activation; Macrophage-Activating Factors; Macrophages; Middle Aged; Neoplasm Metastasis; Prognosis; Tetradecanoylphorbol Acetate; Vitamin D-Binding Protein | 2008 |
Calcium ionophore A-23187 and 12-O-tetradecanoyl-phorbol-13-acetate stimulation of prostaglandin synthesis in herpes simplex virus type 2-transformed rat cells.
Topics: Animals; Calcimycin; Cell Division; Cell Transformation, Neoplastic; Clone Cells; Dinoprost; Dinoprostone; Embryo, Mammalian; Fibrosarcoma; Kinetics; Neoplasm Metastasis; Phorbols; Prostaglandins; Prostaglandins E; Prostaglandins F; Rats; Simplexvirus; Tetradecanoylphorbol Acetate | 1984 |
Inhibited growth of a reticulum cell sarcoma (M5076) induced in vitro and in vivo by macrophage-activating agents.
Topics: Animals; Cell Differentiation; DNA Replication; Female; Lipopolysaccharides; Liver Neoplasms; Lymphoma, Non-Hodgkin; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Ovarian Neoplasms; Phagocytosis; Tetradecanoylphorbol Acetate | 1984 |
Chemotaxis of metastatic tumor cells.
Topics: Animals; Carcinoma 256, Walker; Cell Adhesion; Cells, Cultured; Chemotactic Factors; Chemotaxis; Kinetics; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neoplasm Metastasis; Oligopeptides; Tetradecanoylphorbol Acetate | 1982 |
Real-time PET analysis of metastatic tumor cell trafficking in vivo and its relation to adhesion properties.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Adhesion; Computer Systems; Endothelium, Vascular; Female; Integrins; Isoquinolines; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplastic Cells, Circulating; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Tomography, Emission-Computed | 1995 |
A possible role of 92 kDa type IV collagenase in the extramedullary tumor formation in leukemia.
Topics: Collagenases; Glycoproteins; Humans; Interferon-alpha; Interleukin-1; Interleukin-6; Leukemia; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Metastasis; Sarcoma; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinases; Transforming Growth Factor beta; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1995 |
Experimental metastasis and differentiation of murine melanoma cells: actions and interactions of factors affecting different intracellular signalling pathways.
Topics: Animals; Cell Differentiation; Cell Division; Cholera Toxin; Cyclic AMP; Female; H-2 Antigens; Hydrogen-Ion Concentration; In Vitro Techniques; Melanocyte-Stimulating Hormones; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Quantification and morphologic demonstration of reactive oxygen species produced by Walker 256 tumor cells in vitro and during metastasis in vivo.
Topics: Animals; Carcinoma 256, Walker; Cell Adhesion; Endothelium, Vascular; Hydrogen Peroxide; Luminescent Measurements; Male; N-Formylmethionine Leucyl-Phenylalanine; Neoplasm Metastasis; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells.
Topics: Animals; Carcinogens; Catechols; Cell Membrane; Chelating Agents; Cytosol; Hydroquinones; Lung Neoplasms; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Neoplasm Metastasis; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Inbred Lew; Smoke; Smoking; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Phorbol 12-myristate 13-acetate enhances nm23 gene expression in murine melanocytes but not in syngeneic B16-BL6 melanoma variants.
Topics: Animals; Cell Division; Cell Membrane; Cytosol; Female; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Melanocytes; Melanoma, Experimental; Mice; Monomeric GTP-Binding Proteins; Neoplasm Metastasis; NM23 Nucleoside Diphosphate Kinases; Nucleoside-Diphosphate Kinase; Phenylalanine; Protein Kinase C; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured; Tyrosine | 1996 |
Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Transformed; Cell Transformation, Neoplastic; Disease Progression; Endothelial Growth Factors; Female; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, ras; Interleukin 1 Receptor Antagonist Protein; Keratinocytes; Lymphokines; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred SENCAR; Neoplasm Metastasis; Neoplasm Proteins; Neovascularization, Pathologic; Oncogene Protein p21(ras); Papilloma; Precancerous Conditions; Proto-Oncogene Proteins p21(ras); RNA, Messenger; RNA, Neoplasm; Sialoglycoproteins; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1996 |
Tumor cell-endothelial cell interactions: evidence for roles for lipoxygenase products of arachidonic acid in metastasis.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Calcimycin; Cattle; Cell Adhesion; Endothelium, Vascular; Humans; Lipoxygenase; Lipoxygenase Inhibitors; Masoprocol; N-Formylmethionine Leucyl-Phenylalanine; Neoplasm Metastasis; Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Early events of metastasis in the microcirculation involve changes in gene expression of cancer cells. Tracking mRNA levels of metastasizing cancer cells in the chick embryo chorioallantoic membrane.
Topics: Actins; Allantois; Animals; Chick Embryo; Chorion; Gene Expression Regulation, Neoplastic; Genes, fos; Melanoma, Experimental; Mice; Microcirculation; Microscopy, Fluorescence; Microscopy, Video; Neoplasm Metastasis; Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1997 |
Influence of hyaluronic acid or phorbol 12-myristate 13-acetate on the migration capacity of a murine lymphoma cell line (Eb) and its metastatic variant (ESb).
Topics: Animals; Antibodies, Monoclonal; Cell Movement; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Hyaluronan Receptors; Hyaluronic Acid; Ligands; Lymphoma, T-Cell; Mice; Neoplasm Metastasis; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Production of interleukin-11 in bone-derived endothelial cells and its role in the formation of osteolytic bone metastasis.
Topics: Animals; Bone Marrow Cells; Bone Neoplasms; Cell Line, Transformed; Cells, Cultured; Culture Media, Conditioned; Endothelium; Femur; Humans; Interleukin-1; Interleukin-11; Knee Joint; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Osteolysis; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured | 1998 |
Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Cells, Cultured; Cytokines; Ephrin-B2; Gene Expression Regulation, Neoplastic; Humans; Infant, Newborn; Melanocytes; Melanoma; Membrane Proteins; Mice; Mice, Nude; Neoplasm Metastasis; Nevus, Pigmented; Polymerase Chain Reaction; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transplantation, Heterologous; Tumor Cells, Cultured; Ultraviolet Rays | 1998 |
Activation of tissue-factor gene expression in breast carcinoma cells by stimulation of the RAF-ERK signaling pathway.
Topics: Base Sequence; Benzoquinones; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Dactinomycin; DNA, Complementary; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Genistein; Humans; Hydroquinones; Lactams, Macrocyclic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neovascularization, Pathologic; NF-kappa B; Okadaic Acid; Phenols; Proto-Oncogene Proteins c-raf; Quinones; Rifabutin; Signal Transduction; Tetradecanoylphorbol Acetate; Thromboplastin; Transcription Factor AP-1; Transcription, Genetic; Tretinoin; Tumor Cells, Cultured | 1998 |
The effect of protein kinase C inhibitors on invasion of human ovary cancer cells.
Topics: Aged; Cell Adhesion; Cell Movement; Collagen; Down-Regulation; Enzyme Inhibitors; Female; Fibronectins; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Ovarian Neoplasms; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
[Spontaneous reversion of tumor cells as a source of dormant metastases].
Topics: Animals; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Culture Media; Growth Substances; Mice; Neoplasm Metastasis; Proto-Oncogene Proteins c-jun; Sarcoma, Experimental; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1998 |
Angiogenic capacity and lung-colonizing potential in vivo is increased in weakly metastatic B16F1 cells and decreased in highly metastatic BL6 cells by phorbol esters.
Topics: Animals; Carcinogens; Endothelial Growth Factors; Fibroblast Growth Factors; Lung Neoplasms; Lymphokines; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasm Transplantation; Neovascularization, Pathologic; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Overexpression of protein kinase C-alpha in MCF-7 breast cancer cells results in differential regulation and expression of alphavbeta3 and alphavbeta5.
Topics: Animals; Breast Neoplasms; Cell Adhesion; Dimerization; Enzyme Induction; Female; Gene Expression Regulation, Neoplastic; Humans; Integrins; Isoenzymes; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Transplantation; Osteopontin; Protein Kinase C; Protein Kinase C-alpha; Receptors, Vitronectin; Recombinant Fusion Proteins; Sialoglycoproteins; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Vitronectin | 1999 |
Opposite effects of TPA on G1/S transition and on cell size in the low metastatic B16F1 with respect to high metastatic BL6 murine melanoma cells.
Topics: Animals; Carcinogens; Cell Cycle; Cell Size; Enzyme Activation; G1 Phase; Melanoma; Mice; Neoplasm Metastasis; Protein Kinase C; S Phase; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Induction of melanoma in TPras transgenic mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Albinism; Animals; Carcinoma; Gene Expression Regulation; Genes, ras; Genetic Predisposition to Disease; Hair Color; Hyperplasia; Melanocytes; Melanoma; Mice; Mice, SCID; Mice, Transgenic; Monophenol Monooxygenase; Neoplasm Metastasis; Neoplasms, Radiation-Induced; Papilloma; Promoter Regions, Genetic; Skin Neoplasms; Skin Pigmentation; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1999 |
TPA-enhanced motility and invasion in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1: selective role of PKC-alpha and its inhibition by a combination of PDBu-induced PKC downregulation and antisense oligonucleotides trea
Topics: Adenocarcinoma; Base Sequence; Carbazoles; Down-Regulation; Humans; Indoles; Isoenzymes; Naphthalenes; Neoplasm Invasiveness; Neoplasm Metastasis; Oligonucleotides, Antisense; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Protein Kinase C-alpha; Rectal Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Urokinase (u-PA) and the u-PA receptor. Modulation of in vitro invasiveness of human bladder cancer cell lines.
Topics: Basement Membrane; Collagen; Drug Combinations; Epidermal Growth Factor; Humans; Interferon-gamma; Laminin; Neoplasm Invasiveness; Neoplasm Metastasis; Proteoglycans; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Urokinase-Type Plasminogen Activator | 1999 |
Induction of KAI-1 expression in metastatic cancer cells by phorbol esters.
Topics: Antigens, CD; Carcinogens; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Kangai-1 Protein; Male; Membrane Glycoproteins; Neoplasm Metastasis; Prostatic Neoplasms; Protein Kinase C; Proto-Oncogene Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Overexpression of novel protein kinase C delta in BL6 murine melanoma cells inhibits the proliferative capacity in vitro but enhances the metastatic potential in vivo.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Bryostatins; Cell Cycle; Cell Division; Cyclic AMP; Isoenzymes; Lactones; Macrolides; Melanins; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasm Proteins; Protein Isoforms; Protein Kinase C; Protein Kinase C-delta; Recombinant Fusion Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 2000 |
Human neutrophils facilitate tumor cell transendothelial migration.
Topics: Adenocarcinoma; Adult; Antibodies, Monoclonal; Apoptosis; Breast Neoplasms; Capillaries; Carcinogens; Cell Division; Cell Movement; Culture Media, Conditioned; Endothelium, Vascular; Female; Flow Cytometry; Humans; Integrin beta1; Intercellular Adhesion Molecule-1; Lipopolysaccharides; Neoplasm Metastasis; Neutralization Tests; Neutrophils; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Umbilical Veins | 2001 |
Regulation of differentiation- and proliferation-inducers on Lewis antigens, alpha-fucosyltransferase and metastatic potential in hepatocarcinoma cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Adhesion; Cell Differentiation; Cell Division; Cell Movement; Epidermal Growth Factor; Fucosyltransferases; Humans; Lewis Blood Group Antigens; Lewis X Antigen; Liver Neoplasms; Neoplasm Metastasis; Phenotype; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 2001 |
[Mechanism of the activation of extracellular signal-regulated kinase (ERK) in prostate cancer cell lines with different metastatic potential].
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Enzyme Activation; Humans; Male; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinases; Neoplasm Metastasis; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Receptors, Purinergic P2; Tetradecanoylphorbol Acetate | 2001 |
Dissimilar invasive and metastatic behavior of vincristine and doxorubicin-resistant cell lines derived from a murine T cell lymphoid leukemia.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Cell Division; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Hyaluronan Receptors; Hyaluronic Acid; Lymphoma, T-Cell; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Transplantation; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vincristine | 2002 |
Intracellular regulation of cell adhesion to extracellular matrix components in murine B16 melanoma cells.
Topics: Animals; Calmodulin; Cell Adhesion; Clone Cells; Collagen; Cyclic AMP; Dideoxyadenosine; Extracellular Matrix; Fibronectins; Kinetics; Laminin; Melanocyte-Stimulating Hormones; Melanoma, Experimental; Mice; Naphthalenes; Neoplasm Metastasis; Protein Kinase C; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Regulation of protein kinase A activation and prostaglandin E2-stimulated migration of Lewis lung carcinoma clones.
Topics: Animals; Cell Movement; Cyclic AMP; Dinoprostone; Enzyme Activation; Gene Expression; Lung Neoplasms; Mice; Neoplasm Metastasis; Phosphoproteins; Protein Kinase C; Protein Kinases; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Metastatic potential of mouse skin carcinomas produced by different protocols of chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; DNA, Neoplasm; Female; gamma-Glutamyltransferase; Lung Neoplasms; Methylnitronitrosoguanidine; Mice; Neoplasm Metastasis; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
Identification and characterization of a low-affinity granulocyte-macrophage colony-stimulating factor receptor on primary and cultured human melanoma cells.
Topics: Cell Line; Cells, Cultured; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Kinetics; Melanoma; Neoplasm Metastasis; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Recombinant Proteins; Tetradecanoylphorbol Acetate | 1991 |
Effect of inflammatory cytokines on the adherence of tumor cells to endothelium in a murine model.
Topics: Amino Acid Sequence; Animals; Cell Adhesion; Culture Media; Cycloheximide; Cytokines; Dactinomycin; Dose-Response Relationship, Drug; Endothelium, Vascular; Interleukin-1; Lipopolysaccharides; Mast-Cell Sarcoma; Membrane Proteins; Mice; Mice, Inbred DBA; Molecular Sequence Data; Neoplasm Metastasis; Oligopeptides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1991 |
Correlation between secretion pattern and metastatic potential from drug-treated 3LL tumor cell line.
Topics: Animals; Calcimycin; Female; Indomethacin; Lung Neoplasms; Mice; Mice, Inbred BALB C; Molecular Weight; Neoplasm Metastasis; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
The differential expression of protein kinase C genes in normal human neonatal melanocytes and metastatic melanomas.
Topics: Gene Expression; Humans; Infant, Newborn; Isoenzymes; Melanocytes; Melanoma; Neoplasm Metastasis; Protein Kinase C; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1991 |
Adenovirus E1A represses protease gene expression and inhibits metastasis of human tumor cells.
Topics: Adenovirus Early Proteins; Base Sequence; Cell Transformation, Neoplastic; Chloramphenicol O-Acetyltransferase; DNA-Binding Proteins; Gene Expression; Humans; Metalloendopeptidases; Microbial Collagenase; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasm Metastasis; Oncogene Proteins, Viral; Peptide Hydrolases; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Transfection | 1990 |
Identification of a serum-inducible messenger RNA (5B10) as the mouse homologue of calcyclin: tissue distribution and expression in metastatic, ras-transformed NIH 3T3 cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Amino Acid Sequence; Animals; Base Sequence; Calcium-Binding Proteins; Cell Cycle Proteins; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chick Embryo; Fibroblasts; Gene Expression Regulation; Mice; Mice, Nude; Molecular Sequence Data; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Transplantation; Oncogene Protein p21(ras); Organ Specificity; S100 Calcium Binding Protein A6; S100 Proteins; Simian virus 40; Species Specificity; Tetradecanoylphorbol Acetate | 1990 |
Possible involvement of Ca2+ mobilization and protein kinase C activation in the induction of spontaneous metastasis by mouse mammary adenocarcinoma cells.
Topics: Animals; Calcimycin; Calcium; DNA; Enzyme Activation; Mammary Neoplasms, Experimental; Mice; Mice, Inbred CBA; Neoplasm Metastasis; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Effect of tight junctional resistance on penetration of LLC-PK1 epithelial cell layers by metastatic B16-F10 melanoma cells.
Topics: Animals; Cell Division; Cell Line; Electric Conductivity; Epithelium; Intercellular Junctions; Melanoma, Experimental; Microscopy, Fluorescence; Neoplasm Metastasis; Swine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Collagenase and elastase production by mouse mammary adenocarcinoma primary cultures and cloned cells.
Topics: Adenocarcinoma; Animals; Cells, Cultured; Clone Cells; Collagen; Female; Mammary Neoplasms, Experimental; Mice; Microbial Collagenase; Neoplasm Invasiveness; Neoplasm Metastasis; Pancreatic Elastase; Tetradecanoylphorbol Acetate | 1986 |
Induction of differentiation as a means of modifying metastatic behaviour.
Topics: Animals; Cell Differentiation; Cell Line; Humans; Lipopolysaccharides; Lymphoma, Large B-Cell, Diffuse; Melanoma; Neoplasm Metastasis; Tetradecanoylphorbol Acetate | 1988 |
Differences between the F10, BL6 and F1 sublines of the B16 melanoma in the enhancement of plasminogen activator and plasminogen activator inhibitor secretion by phorbol myristate acetate.
Topics: Animals; Cell Line; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Melanoma; Mice; Neoplasm Metastasis; Plasminogen Activators; Plasminogen Inactivators; Tetradecanoylphorbol Acetate; Urokinase-Type Plasminogen Activator | 1987 |
Tumor progression in vitro: tumor-promoter-induced reversible decrease in natural immune susceptibility.
Topics: Animals; Antibodies, Neoplasm; Complement System Proteins; Cytotoxicity, Immunologic; Immunity, Cellular; Immunity, Innate; Immunologic Surveillance; Killer Cells, Natural; Macrophages; Mice; Mice, Inbred DBA; Neoplasm Metastasis; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Water-Electrolyte Balance | 1988 |
Tumor promoter-induced membrane-bound protein kinase C regulates hematogenous metastasis.
Topics: Animals; Carcinogens; Cell Line; Cell Membrane; Cytosol; Enzyme Induction; Kinetics; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Tetradecanoylphorbol Acetate | 1988 |
Inhibition and augmentation of lymphoma metastasis by adoptively transferred peritoneal macrophages in hamster.
Topics: Animals; Antibodies, Monoclonal; Cricetinae; Female; Immunization, Passive; Lymphokines; Lymphoma; Macrophage Activation; Macrophages; Neoplasm Metastasis; Tetradecanoylphorbol Acetate | 1986 |
Effects of 12-O-tetradecanoylphorbol-13-acetate on adhesiveness and lung-colonizing ability of Lewis lung carcinoma cells.
Topics: Animals; Cell Adhesion; Diglycerides; Diterpenes; Lung Neoplasms; Male; Mice; Mitogens; Neoplasm Metastasis; Phorbol Esters; Phorbols; Protein Kinases; Structure-Activity Relationship; Terpenes; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1986 |