tetradecanoylphorbol acetate has been researched along with Melanoma in 154 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 49 (31.82) | 18.7374 |
| 1990's | 60 (38.96) | 18.2507 |
| 2000's | 29 (18.83) | 29.6817 |
| 2010's | 16 (10.39) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kalinovsky, T; Niedzwiecki, A; Rath, M; Roomi, MW | 1 |
| Liu, P; Wang, D | 1 |
| Kniess, T; Laube, M; Meister, S; Mosch, B; Neuber, C; Pietzsch, J; Tondera, C; Ullm, S | 1 |
| Athar, M; Cochran, JB; Elmets, CA; McKay, KM; Nasti, TH; Timares, L; Tsuruta, Y; Yusuf, N | 1 |
| Fukushima, K; Fukushima, N; Honoki, K; Takahashi, K; Tsujiuchi, T | 1 |
| Davidson, B; Flørenes, VA; Jørgensen, K; Rosnes, AK; Skrede, M; Slipicevic, A; Trøen, G | 1 |
| Camilli, TC; Fiori, JL; Frank, BP; French, AD; Indig, FE; Leotlela, PD; O'Connell, MP; Subaran, S; Taub, DD; Weeraratna, AT | 1 |
| Estrada-Bernal, A; Gatlin, JC; Pfenninger, KH; Sunpaweravong, S | 1 |
| Bito, T; Fukami, Y; Iwasaki, T; Kageshita, T; Nishigori, C; Oka, M; Sakaguchi, M; Sato, K; Sumita, N | 1 |
| Fässler, R; Khochbin, S; Masoumi, KC; Massoumi, R; Wickström, SA | 1 |
| Choi, CY; Choi, JH; Choi, JM; Chung, YC; Han, EH; Hwang, YP; Jeong, HG; Seo, JK | 1 |
| Czajkowski, R | 1 |
| Holmen, SL; McKinney, AJ | 1 |
| Boe, A; Bottero, L; Carè, A; Colombo, MP; Di Virgilio, A; Errico, MC; Felicetti, F; Mattia, G; Petrini, M; Romania, P; Segnalini, P; Tomasello, L | 1 |
| Katiyar, SK; Singh, T | 1 |
| Chu, LY; Silverstein, RL | 1 |
| Ansari, KM; Das, M; Kumar, R | 1 |
| Hayward, R; Lo, RS; Marais, R; Martin, M; Niculescu-Duvaz, D; Sanchez-Laorden, B; Springer, C; Viros, A; Yashar, S; Yu, CC; Zambon, A | 1 |
| Cucinotta, M; Oteri, R; Teti, D; Venza, I; Venza, M; Visalli, M | 1 |
| Braeuning, A; Münzel, PA; Schwarz, M | 1 |
| Chen, M; Corpron, C; Harmon, CM; Pych, E | 1 |
| Bizik, J; Cario-André, M; Gontier, E; Surlève-Bazeille, JE; Taïeb, A; Vergnes, P | 1 |
| Bartolazzi, A; Del Prete, F; Gasbarri, A; Girnita, L; Martegani, MP; Natali, PG | 1 |
| Hedley, D; Karasarides, M; Marais, R; Martin, J; Niculescu-Duvaz, D; Ogilvie, L; Springer, CJ; Wellbrock, C | 1 |
| Fisher, PB; Laskin, JD; Mufson, RA; Weinstein, IB | 1 |
| ChaMberlin, J; Kroll, TM; Le Poole, IC; Miki, T; Nickoloff, BJ; Riker, AI; Stennett, LS | 1 |
| Meyskens, FL; Yang, S | 1 |
| Cruciani, V; Flørenes, VA; Jørgensen, K; Mikalsen, SO; Skrede, M; Slipicevic, A | 1 |
| Gillespie, S; Hersey, P; Zhang, XD | 1 |
| Kurschat, P; Löffek, S; Mauch, C; Smola, H; Steiger, J; Zigrino, P | 1 |
| Bastian, BC; Curtin, JA; Dumaz, N; Hayward, R; Hedley, D; Marais, R; Martin, J; Ogilvie, L; Springer, C | 1 |
| Boyle, GM; Cozzi, SJ; Ogbourne, SM; Parsons, PG; Pedley, J | 1 |
| Carosella, ED; Guillard, C; Krawice-Radanne, I; Marcou, C; Moreau, P; Rouas-Freiss, N; Sangrouber, D; Zidi, I | 1 |
| Agarwal, R; Bernier, M; D'Souza, T; He, HJ; Kole, S; Morin, PJ; Zhu, TN | 1 |
| Fisher, PB; Mufson, RA; Weinstein, IB | 2 |
| Ludwig, KW; Niles, RM | 1 |
| Lotan, D; Lotan, R | 1 |
| Eisinger, M; Greenebaum, E; Nicolaides, M; Vogel, RH; Weinstein, IB | 1 |
| Bernfeld, P; Homburger, F | 1 |
| Mascardo, RN; Sherline, P | 1 |
| Ashino-Fuse, H; Billiau, A; Fuse, A; Opdenakker, G | 1 |
| Ashino-Fuse, H; Billiau, A; De Somer, P; Opdenakker, G; Van Damme, J | 1 |
| Fisher, PB; Hermo, H; Pestka, S; Prignoli, DR; Weinstein, IB | 1 |
| Carubia, JM; Kirkwood, JM; Macala, LJ; Varga, JM; Yu, RK | 1 |
| Goerttler, K; Hesse, B; Loehrke, H; Schweizer, J | 1 |
| Schwab, M | 1 |
| Fisher, PB; Fujiki, H; Miranda, AF; Mufson, RA; Sugimura, T; Weinstein, IB; Weinstein, LS | 1 |
| Goerttler, K; Hecker, E; Hesse, B; Loehrke, H; Schweitzer, J; Seip, H | 1 |
| Callaham, M; Huberman, E; Slaga, T; Solanki, V; Weeks, C | 1 |
| Albino, AP; Cairncross, JG; Eisinger, M; Houghton, AN; Old, LJ | 1 |
| Fodstad, O; Johannessen, JV; Olsnes, S; Tveit, KM | 1 |
| Blusztajn, JK; Desai, S; Gruber, JR; Niles, RM | 1 |
| Arbiser, JL; Bruijn, JA; Byers, HR; Dekker, SK; van Leeuwen, RL; Vermeer, BJ | 1 |
| Diez, E; Gervois, N; Guilloux, Y; Jotereau, F; Le Dréan, E; Pandolfino, MC; Viret, C | 1 |
| Carsberg, CJ; Friedmann, PS; Warenius, HM | 1 |
| Altomonte, M; Brasoveanu, LI; Cattarossi, I; Cattelan, A; Coral, S; Fonsatti, E; Gasparollo, A; Gloghini, A; Montagner, R; Simonelli, C | 1 |
| Karhunen, T; Pavel, S; Slingerland, R; Smit, N; Tilgmann, C; Ulmanen, I; Westerhof, W | 1 |
| Buffolino, P; Coppock, DL; Kopman, C; Nathanson, L | 1 |
| Alizadeh, H; Niederkorn, JY; Pidherney, MS; Taylor, WM | 1 |
| Birch, ML; Buckmeier, JA; Graham, MJ; Meyskens, FL; Powell, MB; Rosenberg, RK; Yamanishi, DT | 1 |
| Der, JE; Dixon, WT; Horikoshi, T; Jimbow, K | 1 |
| Joshi-Barve, SS; Rangnekar, VM; Rangnekar, VV; Sells, SF | 1 |
| Albino, AP; Dosik, JS; Loganzo, F; Nanus, DM; Sudol, M; Vidal, MJ; Zhao, Y | 1 |
| Mueller, BM; Stahl, A | 1 |
| Castronovo, V; French, DL; Lauricella-Lefebvre, MA; Merville, MP; Sato, H; Seiki, M | 1 |
| Bennett, DC; Devlin, L; Hart, IR; Holmes, A | 1 |
| Bitonti, AJ; Dumont, JA | 1 |
| Cecchi, C; Mapelli, E; Sanfilippo, O; Supino, R | 1 |
| Drexler, HG; Grunicke, D; Steube, KG | 1 |
| Ayusawa, D; Fujiwara, J; Kimura, T; Oishi, M | 1 |
| Coppock, DL; Nathanson, L | 1 |
| Banfi, P; Gambetta, RA; Mapelli, E; Sala, E; Sensi, M; Supino, R; Zunino, F | 1 |
| Chapman, PB; Houghton, AN; Minasian, LM; Morrison, ME; Nathan, CF; Rosenblum, M; Steffens, T; Szatrowski, TP; Williams, L | 1 |
| Arita, Y; O'Driscoll, KR; Weinstein, IB | 1 |
| Bracke, M; de Bruyne, G; Houde, M; Ingelman-Sundberg, M; Masure, S; Opdenakker, G; Skoglund, G; van Damme, J | 1 |
| Albright, KD; Christen, RD; Howell, SB; Jones, JA; McClay, EF | 1 |
| Ando, H; Hayashibe, K; Horikawa, T; Ichihashi, M; Kikkawa, U; Ogita, K; Oka, M; Saito, N | 1 |
| Eguchi, H; Horikoshi, T | 1 |
| Corbitt, RH; Cottam, DW; Gomez, DE; Rees, RC; Thorgeirsson, UP | 1 |
| Janik, P; Kowalczyk, D; Maternicka, K; Miłoszewska, J; Szaniawska, B | 1 |
| Hayashi, H; Inukai, Y; Mizutani, Y; Onozaki, K; Takii, T; Yang, D | 1 |
| Cai, Y; Honn, KV; Lundy, SK; Porter, AT; Szekeres, K; Timar, J; Trikha, M | 1 |
| Fink-Puches, R; Helige, C; Hofmann-Wellenhof, R; Smolle, J; Tritthart, HA; Zellnig, G | 1 |
| Jung, B; Kerbel, RS; Kobayashi, H; Landthaler, M; McClelland, M; Stolz, W; Vogt, T; Welsh, J | 1 |
| Arita, Y; Buffolino, P; Coppock, DL | 1 |
| Ahmed, NU; Fenner, MH; Isselbacher, KJ; Li, H; Shioda, T; Ueda, M | 1 |
| Clément, MV; Pervaiz, S; Ponton, A | 1 |
| Ablett, E; Dannoy, PA; Parsons, PG; Pedley, J; Sturm, RA | 1 |
| Fang, D; Setaluri, V | 1 |
| Comolli, R; La Porta, CA; Porro, D | 1 |
| Bowden, GT; Broome Powell, M; Gause, PR; Gregus, J; Hyman, P; Lluria-Prevatt, M; Nagle, R | 1 |
| Anderegg, U; Haustein, UF; Saalbach, A; Wetzig, T | 1 |
| Byzova, TV; Kim, W; Midura, RJ; Plow, EF | 1 |
| Asai, T; Storkus, WJ; Whiteside, TL | 1 |
| Bogdanov, V; Fallon, JT; Fisher, EA; Giesen, PL; Nemerson, Y; Rossikhina, M; Schecter, AD; Schnapp, LM; Spirn, B; Taubman, MB | 1 |
| Barral, AM; Källström, R; Rosén, A; Sander, B | 1 |
| Arita, Y; Coppock, DL; Santiago-Schwarz, F | 1 |
| Fang, D; Hallman, J; Hammarback, JA; Kute, TE; Sangha, N; Setaluri, V; White, WL | 1 |
| Kelly, K; Leone, A; Mitsiades, N; Poulaki, V; Spinelli, B; Tsokos, M; Ward, Y | 1 |
| Berger, A; Hermann, A; Kofler, B; Lang, R | 1 |
| Comolli, R; La Porta, CA | 1 |
| Alexandre, D; Chada, S; Chen, Y; Christiansen, KA; Fisher, PB; Goldstein, NI; Gopalkrishnan, RV; Huang, EY; Huberman, E; Jiang, H; Kang, D; Lebedeva, IV; Leszczyniecka, M; Lin, JJ; Madireddi, MT; Mei, MX; Mhashilkar, AB; Pestka, S; Sivo, F; Su, Z; Vozhilla, N | 1 |
| Amodeo, DM; Byers, HR; Dekker, SK; Jalbert, NL; Leccia, MT; van der Gaag, EJ | 1 |
| Hitomi, T; Ichihashi, M; Kikkawa, U; Kuroki, T; Nagai, H; Nakamura Si, S; Ohba, M; Oka, M; Okada, T | 1 |
| Heckman, C; Huberman, E; Langenbach, R | 1 |
| Donatien, PD; Hunt, G; Lunec, J; Pieron, C; Taïeb, A; Thody, AJ | 1 |
| Ansel, JC; Armstrong, CA; Hart, CE; Köck, A; Luger, TA; Tara, DC | 1 |
| Johnson, AC; Kageyama, R; Pastan, I; Popescu, NC | 1 |
| Caraglia, M; Celio, L; Coppola, V; Correale, P; Genua, G; Normanno, N; Palmieri, G; Pepe, S; Procopio, A; Vecchio, I | 1 |
| Coppock, DL; Nathanson, L; Tansey, JB | 1 |
| Chandler, CF; Economou, JS; Lee, JD; McBride, WH; Morton, DL; Sievers, TM; Skotzko, M | 1 |
| Albino, AP; Houghton, AN; Jhanwar, SC; Nanus, DM; Sozzi, G | 1 |
| Buckmeier, JA; Graham, MJ; Hickie, RA; Meyskens, FL | 1 |
| DiGregorio, FM; Hashimoto, K; Ishihara, M; Pietruk, T; Richards, J; Setoyama, M; Zarbo, RJ | 1 |
| Coppock, DL; Nathanson, L; Scandalis, S; Tansey, JB | 1 |
| Kapp, A; Komann, A; Schöpf, E | 1 |
| Baldwin, GC; Economou, J; Gasson, JC; Golde, DW; Widhopf, GF | 1 |
| Gilchrest, BA; Grichnik, JM | 1 |
| Collart, FR; Henning-Chubb, C; Huberman, E; Kiguchi, K | 1 |
| Buckmeier, JA; Graham, M; Meyskens, FL; Yamanishi, DT | 1 |
| Brown, PD; Levy, AT; Liotta, LA; Margulies, IM; Stetler-Stevenson, WG | 1 |
| Baglioni, C; Johnson, SE | 1 |
| Arita, Y; Eisinger, M; Furukawa, K; Lloyd, KO; Satomi, N | 1 |
| Becker, D; Beebe, SJ; Herlyn, M | 1 |
| Fisher, PB; Grant, S | 1 |
| Duray, P; Ghosh, S; Halaban, R; Kirkwood, JM; Lerner, AB | 1 |
| Albino, AP; Eisinger, M; Houghton, AN; Kantor, RR; Lee, JS; Old, LJ; Oliff, AI | 1 |
| Herlyn, M; Koprowski, H; Rakowicz-Szulczyńska, EM | 1 |
| Akai, H; Larner, AC | 1 |
| Benezra, M; Gerst, JE; Salomon, Y; Schimmer, A | 1 |
| Edwalds, GM; Ferrone, S; Fisher, PB; Guarini, L; Temponi, M; Vita, JR | 1 |
| Dooley, TP; Hart, IR; Wilson, RE | 1 |
| Dixon, WT; Feyles, V; Jerry, LM; Sikora, LK | 1 |
| Abe, E; Chida, K; Hashiba, H; Hosoi, J; Hosomi, J; Kuroki, T; Sasaki, K; Suda, T | 1 |
| Berlin, RD; Pearson, CM; Preston, SF; Volpi, M | 1 |
| Barna, BP; Deodhar, SD; James, K | 1 |
| Goode, NT; Hart, IR; Ormerod, EJ | 1 |
| Kanno, J; Kasuga, T; Matsubara, O | 1 |
| Billiau, A; Bosman, F; Opdenakker, G; Van Damme, J | 2 |
| Nabi, ZF; Zucker-Franklin, D | 2 |
| Bennett, DC; Cooper, PJ; Hart, IR | 1 |
| Cordon-Cardo, C; Davis, LJ; Houghton, AN; Old, LJ; Real, FX | 1 |
| Hart, DA; Smith, R | 1 |
| Mason, RS; Posen, S; Ranson, M | 1 |
| Pályi, I | 1 |
| Adey, WR; Byus, CV; Kartun, K; Pieper, S | 1 |
| Biedler, JL; Old, LJ; Real, FX; Rettig, WJ; Spengler, BA | 1 |
| Blumberg, PM; Kochenburger, RJ; Little, JB; Lovett, DR; Nagasawa, H; Schmit, A; Weichselbaum, RR | 1 |
| Adams, DO; Dean, JH; Lauer, LD; Luebke, RW; Luster, MI; Murray, MJ | 1 |
| Johnson, J; Munker, R; Petersmann, I; Riethmüller, G; Schmoeckel, C; Ziegler-Heitbrock, HW | 1 |
| Eisinger, M; Marko, O; Ogata, S; Old, LJ | 1 |
5 review(s) available for tetradecanoylphorbol acetate and Melanoma
| Article | Year |
|---|---|
Animal models of melanoma: a somatic cell gene delivery mouse model allows rapid evaluation of genes implicated in human melanoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Avian Leukosis Virus; Avian Proteins; Cell Line, Tumor; Disease Models, Animal; Gene Transfer Techniques; Genetic Vectors; Humans; Melanocytes; Melanoma; Melanoma, Experimental; Mice; Mice, Transgenic; Neoplasm Transplantation; Receptors, Virus; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transgenes | 2011 |
Non-melanoma skin cancer in mouse and man.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Disease Progression; Genes, p53; Genes, ras; Humans; Melanoma; Mice; Mutation; Neoplasm Invasiveness; Neoplastic Stem Cells; Papilloma; Risk Assessment; Skin; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 2013 |
Positive and negative growth regulation in melanoma: growth factors, intracellular signalling, and the cell cycle.
Topics: Animals; Cell Cycle; Cell Transformation, Neoplastic; Fibroblast Growth Factor 2; Growth Substances; Humans; Melanocytes; Melanoma; Protein Kinase C; Protein Kinases; Signal Transduction; Tetradecanoylphorbol Acetate | 1993 |
Phorbol esters and growth regulation in metastatic melanoma cells.
Topics: Cell Cycle; Cell Division; Humans; Melanocytes; Melanoma; Phorbol Esters; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1991 |
Effects of interferon on differentiation of normal and tumor cells.
Topics: Adipose Tissue; Animals; Cell Differentiation; Cells, Cultured; Dimethyl Sulfoxide; Hematopoiesis; Humans; Interferons; Leukemia; Leukemia, Erythroblastic, Acute; Melanins; Melanoma; Mice; Muscles; Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1985 |
1 trial(s) available for tetradecanoylphorbol acetate and Melanoma
| Article | Year |
|---|---|
Hemorrhagic tumor necrosis during a pilot trial of tumor necrosis factor-alpha and anti-GD3 ganglioside monoclonal antibody in patients with metastatic melanoma.
Topics: Adult; Aged; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Female; Gangliosides; Humans; Male; Melanoma; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Necrosis; Neutrophils; Recombinant Proteins; Tetradecanoylphorbol Acetate; Tumor Lysis Syndrome; Tumor Necrosis Factor-alpha | 1994 |
148 other study(ies) available for tetradecanoylphorbol acetate and Melanoma
| Article | Year |
|---|---|
Modulation of MMP-2 and -9 secretion by cytokines, inducers and inhibitors in human melanoma A-2058 cells.
Topics: Catechin; Cell Line, Tumor; Cytokines; Doxycycline; Humans; Interleukin-1beta; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Melanoma; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2017 |
Ingenol-3-Angelate Suppresses Growth of Melanoma Cells and Skin Tumor Development by Downregulation of NF-κB-Cox2 Signaling.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Apoptosis Regulatory Proteins; Carcinogenesis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclooxygenase 2; Diterpenes; Down-Regulation; Epidermis; Female; Hyperplasia; Inflammation; Melanoma; Mice, Inbred ICR; NF-kappa B; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2018 |
Optical imaging of COX-2: studies on an autofluorescent 2,3-diaryl-substituted indole-based cyclooxygenase-2 inhibitor.
Topics: Animals; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Female; Heterografts; Humans; Indoles; Melanoma; Mice, Inbred Strains; Molecular Probes; Optical Imaging; Sulfonamides; Tetradecanoylphorbol Acetate | 2015 |
A murine model for the development of melanocytic nevi and their progression to melanoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Line, Tumor; Cell Separation; Cyclin-Dependent Kinase Inhibitor p16; Disease Models, Animal; Disease Progression; Melanoma; Mice; Mice, Nude; Mutation; Neoplasm Proteins; Nevus, Pigmented; ras Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2016 |
Different effects of GPR120 and GPR40 on cellular functions stimulated by 12-O-tetradecanoylphorbol-13-acetate in melanoma cells.
Topics: Carcinogens; Cell Line, Tumor; Cell Movement; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Melanoma; Receptors, G-Protein-Coupled; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2016 |
The fatty acid binding protein 7 (FABP7) is involved in proliferation and invasion of melanoma cells.
Topics: Biomarkers, Tumor; Carcinogens; Carrier Proteins; Cell Nucleus; Cell Proliferation; Cytoplasm; Disease Progression; Enzyme Inhibitors; Fatty Acid-Binding Protein 7; Flavonoids; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Immunoenzyme Techniques; Melanoma; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Nevus, Pigmented; Oligonucleotide Array Sequence Analysis; Prognosis; RNA, Messenger; RNA, Small Interfering; Skin Neoplasms; Survival Rate; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2008 |
PKC and PKA phosphorylation affect the subcellular localization of claudin-1 in melanoma cells.
Topics: Biological Transport; Cell Line, Tumor; Cell Nucleus; Claudin-1; Computer Simulation; Cyclic AMP-Dependent Protein Kinases; Cytoplasm; Enzyme Activation; Genetic Vectors; Humans; Immunohistochemistry; Matrix Metalloproteinase 2; Melanoma; Membrane Proteins; Mutagenesis, Site-Directed; Neoplasm Invasiveness; Neoplasm Metastasis; Nuclear Localization Signals; Phosphorylation; Protein Kinase C; Subcellular Fractions; Tetradecanoylphorbol Acetate; Transfection | 2009 |
Dynamic adhesions and MARCKS in melanoma cells.
Topics: Animals; Cell Adhesion; Cell Line, Tumor; Cell Movement; Humans; Integrin alpha3; Intercellular Junctions; Intracellular Signaling Peptides and Proteins; Isoenzymes; Melanoma; Melanoma, Experimental; Membrane Proteins; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Paxillin; Protein Kinase C; Rats; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Vinculin | 2009 |
12-O-tetradecanoylphorbol-13-acetate inhibits melanoma growth by inactivation of STAT3 through protein kinase C-activated tyrosine phosphatase(s).
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; CSK Tyrosine-Protein Kinase; DNA; Humans; Melanoma; Phosphorylation; Protein Kinase C; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; src-Family Kinases; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate | 2009 |
CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin.
Topics: Acetylation; Animals; Carcinoma, Adenoid Cystic; Catalytic Domain; Cell Cycle; Cell Line, Tumor; Cytokinesis; Deubiquitinating Enzyme CYLD; Genes, Tumor Suppressor; Histone Deacetylase 6; Histone Deacetylases; Humans; Keratinocytes; Melanocytes; Melanoma; Mice; Microtubules; Mutation; Recombinant Fusion Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tubulin; Tumor Suppressor Proteins | 2010 |
Suppression of PMA-induced tumor cell invasion and metastasis by aqueous extract isolated from Prunella vulgaris via the inhibition of NF-kappaB-dependent MMP-9 expression.
Topics: Administration, Oral; Animals; Cell Movement; Cell Nucleus; Lung Neoplasms; Matrix Metalloproteinase 9; Melanoma; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; Phosphorylation; Plant Extracts; Prunella; Tetradecanoylphorbol Acetate; Translocation, Genetic; Xenograft Model Antitumor Assays | 2010 |
BRAF, HRAS, KRAS, NRAS and CDKN2A genes analysis in cultured melanocytes used for vitiligo treatment.
Topics: Adult; Cell Culture Techniques; Cells, Cultured; Exons; Female; Humans; Male; Melanocytes; Melanoma; Middle Aged; Mutation; Proto-Oncogene Proteins; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); ras Proteins; Tetradecanoylphorbol Acetate; Vitiligo; Young Adult | 2011 |
Constitutive activation of the ETS-1-miR-222 circuitry in metastatic melanoma.
Topics: Animals; Cell Line, Tumor; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Melanocytes; Melanoma; Mice; Mice, Nude; MicroRNAs; Neoplasm Metastasis; Phosphorylation; Phosphothreonine; Proto-Oncogene Mas; Proto-Oncogene Protein c-ets-1; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic | 2011 |
Green tea catechins reduce invasive potential of human melanoma cells by targeting COX-2, PGE2 receptors and epithelial-to-mesenchymal transition.
Topics: Catechin; Celecoxib; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Drug Screening Assays, Antitumor; Epithelial-Mesenchymal Transition; Humans; Melanoma; Neoplasm Invasiveness; NF-kappa B; Pyrazoles; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Sulfonamides; Tea; Tetradecanoylphorbol Acetate; Transcription Factor RelA | 2011 |
CD36 ectodomain phosphorylation blocks thrombospondin-1 binding: structure-function relationships and regulation by protein kinase C.
Topics: Blotting, Western; CD36 Antigens; Cell Line, Tumor; Endothelial Cells; Enzyme Activation; Enzyme Activators; Golgi Apparatus; Humans; Immunoprecipitation; Melanoma; Phosphorylation; Protein Binding; Protein Conformation; Protein Interaction Domains and Motifs; Protein Interaction Mapping; Protein Kinase C-alpha; Protein Synthesis Inhibitors; Protein Transport; src-Family Kinases; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Thrombospondin 1; Time Factors; Transfection | 2012 |
Nexrutine(R) inhibits tumorigenesis in mouse skin and induces apoptotic cell death in human squamous carcinoma A431 and human melanoma A375 cells.
Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Humans; Melanoma; Mice; Plant Extracts; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2012 |
Topical 5-fluorouracil elicits regressions of BRAF inhibitor-induced cutaneous squamous cell carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Squamous Cell; Cell Line; Cell Proliferation; Fluorouracil; Humans; Imidazoles; Indoles; Melanoma; Mice; Oximes; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Sulfonamides; Tetradecanoylphorbol Acetate; Vemurafenib | 2013 |
Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells.
Topics: Acetylation; Cell Line, Tumor; Cell Proliferation; DNA-Directed RNA Polymerases; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Interleukin-8; Melanoma; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-jun; Pyrroles; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factor TFIIB; Transcription, Genetic; Uveal Neoplasms | 2013 |
Regulation of CD36 expression in human melanoma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; CD36 Antigens; Gene Expression Regulation, Neoplastic; Humans; Ibuprofen; Insulin; Melanoma; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 2002 |
The 'Abtropfung phenomenon' revisited: Dermal nevus cells from congenital nevi cannot activate matrix metalloproteinase 2 (MMP-2).
Topics: Adolescent; Cell Line, Tumor; Cell Movement; Cells, Cultured; Child; Child, Preschool; Dermis; Enzyme Activation; Epidermal Growth Factor; Gelatinases; Humans; Infant; Infant, Newborn; Isoenzymes; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinases; Melanoma; Nevus; Nevus, Pigmented; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-2 | 2003 |
CD44s adhesive function spontaneous and PMA-inducible CD44 cleavage are regulated at post-translational level in cells of melanocytic lineage.
Topics: Antimetabolites; Down-Regulation; Gene Expression Regulation, Neoplastic; Glycosylation; Humans; Hyaluronan Receptors; Hyaluronic Acid; Melanoma; Metalloproteases; Mutagenesis, Site-Directed; Neoplasm Proteins; Protein Binding; Protein Processing, Post-Translational; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2003 |
V599EB-RAF is an oncogene in melanocytes.
Topics: Animals; Carcinogens; Cell Line, Tumor; Cell Transformation, Neoplastic; Female; Humans; MAP Kinase Signaling System; Melanocytes; Melanoma; Mice; Mice, Nude; Oncogenes; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; Tetradecanoylphorbol Acetate; Transfection | 2004 |
Melittin shares certain cellular effects with phorbol ester tumour promoters.
Topics: Animals; Arachidonic Acid; Bee Venoms; Bees; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Transformation, Neoplastic; Melanoma; Melitten; Mice; Prostaglandins; Tetradecanoylphorbol Acetate | 1979 |
Expression of gp100 and CDK2 in melanoma cells is not co-regulated by a shared promoter region.
Topics: Carcinogens; CDC2-CDC28 Kinases; Cell Line, Tumor; Cyclin-Dependent Kinase 2; DNA-Binding Proteins; Down-Regulation; Gene Expression Regulation, Neoplastic; gp100 Melanoma Antigen; Humans; Melanoma; Membrane Glycoproteins; Microphthalmia-Associated Transcription Factor; Neoplasm Proteins; Promoter Regions, Genetic; Proteins; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic | 2004 |
Alterations in activating protein 1 composition correlate with phenotypic differentiation changes induced by resveratrol in human melanoma.
Topics: Antioxidants; Apoptosis; Cell Cycle; Cell Line; Cell Line, Tumor; Humans; Infant, Newborn; Melanocytes; Melanoma; Phenotype; Reactive Oxygen Species; Resveratrol; Stilbenes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic | 2005 |
Phorbol ester phorbol-12-myristate-13-acetate promotes anchorage-independent growth and survival of melanomas through MEK-independent activation of ERK1/2.
Topics: Anoikis; Apoptosis; Butadienes; Carbazoles; Cell Adhesion; Cell Culture Techniques; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Progression; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Immunoblotting; Indoles; Melanocytes; Melanoma; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Nitriles; Oligonucleotides, Antisense; Protein Kinase C; Protein Kinase C-alpha; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transfection | 2005 |
Variable expression of protein kinase C epsilon in human melanoma cells regulates sensitivity to TRAIL-induced apoptosis.
Topics: Adenoviridae; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Caspase 8; Caspases; Cell Line, Tumor; Cytosol; Flow Cytometry; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genetic Vectors; Humans; Melanoma; Membrane Glycoproteins; Mitochondria; Phenotype; Plasmids; Protein Conformation; Protein Kinase C; Protein Kinase C-epsilon; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Tetradecanoylphorbol Acetate; TNF-Related Apoptosis-Inducing Ligand; Transfection; Tumor Necrosis Factor-alpha | 2005 |
Melanoma cell-derived vascular endothelial growth factor induces endothelial tubulogenesis within fibrin gels by a metalloproteinase-mediated mechanism.
Topics: Endothelium, Vascular; Fibrin; Gels; Humans; Melanoma; Metalloendopeptidases; Metalloproteases; Neovascularization, Pathologic; Phenanthrolines; Protease Inhibitors; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A | 2006 |
In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling.
Topics: alpha-MSH; Animals; Cell Line, Tumor; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Extracellular Signal-Regulated MAP Kinases; Female; Genes, ras; Humans; Melanocytes; Melanoma; Melanoma, Experimental; Mice; Mice, Nude; Mutation; Neoplasm Proteins; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; Signal Transduction; Tetradecanoylphorbol Acetate | 2006 |
Induction of senescence in diterpene ester-treated melanoma cells via protein kinase C-dependent hyperactivation of the mitogen-activated protein kinase pathway.
Topics: Cell Cycle; Cell Line, Tumor; Cellular Senescence; Diterpenes; E2F1 Transcription Factor; Enzyme Activation; Esters; Gene Silencing; Humans; Isoenzymes; MAP Kinase Signaling System; Melanoma; Phosphorylation; Protein Kinase C; Retinoblastoma Protein; Tetradecanoylphorbol Acetate; Transcription, Genetic | 2006 |
Increase in HLA-G1 proteolytic shedding by tumor cells: a regulatory pathway controlled by NF-kappaB inducers.
Topics: Cell Line; Cell Line, Tumor; Cell Membrane; Choriocarcinoma; Coculture Techniques; Cytotoxicity, Immunologic; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens Class I; HLA Antigens; HLA-G Antigens; Humans; Immunologic Surveillance; Killer Cells, Natural; Melanoma; NF-kappa B; Protein Modification, Translational; Protein Processing, Post-Translational; Tetradecanoylphorbol Acetate; Tumor Escape; Tumor Necrosis Factor-alpha | 2006 |
Filamin A-mediated down-regulation of the exchange factor Ras-GRF1 correlates with decreased matrix metalloproteinase-9 expression in human melanoma cells.
Topics: Carcinogens; Cell Line, Tumor; Cell Movement; Contractile Proteins; Down-Regulation; Filamins; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Melanoma; Microfilament Proteins; Proto-Oncogene Proteins p21(ras); ras-GRF1; Tetradecanoylphorbol Acetate | 2007 |
Interferon inhibits melanogenesis in B-16 mouse melanoma cells.
Topics: Animals; Cell Differentiation; Clone Cells; Interferons; Melanins; Melanocyte-Stimulating Hormones; Melanoma; Mice; Monophenol Monooxygenase; Neoplasms, Experimental; Tetradecanoylphorbol Acetate | 1981 |
Suppression of cyclic AMP-dependent protein kinase activity in murine melanoma cells by 12-0-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cells, Cultured; Cyclic AMP; Kinetics; Melanins; Melanoma; Mice; Neoplasms, Experimental; Phorbols; Protein Kinase Inhibitors; Saccharin; Tetradecanoylphorbol Acetate | 1980 |
Enhancement of melanotic expression in cultured mouse melanoma cells by retinoids.
Topics: Animals; Cell Division; Cells, Cultured; Cyclic AMP; Enzyme Activation; Melanins; Melanocyte-Stimulating Hormones; Melanoma; Mice; Monophenol Monooxygenase; Neoplasms, Experimental; Tetradecanoylphorbol Acetate; Tretinoin | 1981 |
Binding of phorbol dibutyrate and epidermal growth factor to cultured human epidermal cells.
Topics: Caenorhabditis elegans Proteins; Carrier Proteins; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Melanoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Skin painting studies in Syrian hamsters.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cricetinae; Dose-Response Relationship, Drug; Female; Male; Melanoma; Mesocricetus; Neoplasms, Experimental; Nicotiana; Papilloma; Plants, Toxic; Sex Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Tumor promoters stimulate hyperplasia of microtubule organizing center and inhibit DNA synthesis in cultured cells.
Topics: DNA; Growth Inhibitors; HeLa Cells; Humans; Hyperplasia; Kinetics; Lyngbya Toxins; Melanoma; Microtubules; Mitotic Index; Organoids; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Mechanism of the stimulatory effect of phorbol 12-myristate 13-acetate on cellular production of plasminogen activator.
Topics: Cell Line; Cell Survival; Gene Expression Regulation; Humans; Kinetics; Melanoma; Phorbols; Plasminogen Activators; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1984 |
Effects of 12-O-tetradecanoylphorbol 13-acetate on the production of mRNAs for human tissue-type plasminogen activator.
Topics: Animals; Cell Line; Electrophoresis, Polyacrylamide Gel; Female; Humans; Melanoma; Oocytes; Phorbols; Plasminogen Activators; Protein Biosynthesis; Rabbits; Reticulocytes; RNA, Messenger; RNA, Neoplasm; Sodium Dodecyl Sulfate; Tetradecanoylphorbol Acetate; Xenopus laevis | 1983 |
Hybrid recombinant human leukocyte interferon inhibits differentiation in murine B-16 melanoma cells.
Topics: Animals; Cell Differentiation; Cell Line; DNA, Recombinant; Interferon Type I; L Cells; Melanins; Melanocyte-Stimulating Hormones; Melanoma; Mice; Tetradecanoylphorbol Acetate; Two-Hybrid System Techniques | 1984 |
Gangliosides of normal and neoplastic human melanocytes.
Topics: Cell Line; G(M3) Ganglioside; Gangliosides; Humans; Male; Melanocytes; Melanoma; Tetradecanoylphorbol Acetate | 1984 |
Two-stage tumorigenesis of dermal melanocytes in the back skin of the Syrian golden hamster using systemic initiation with 7,12-dimethylbenz(a)anthracene and topical promotion with 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Cocarcinogenesis; Cricetinae; Female; Melanocytes; Melanoma; Mesocricetus; Neoplasms, Experimental; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
How can altered differentiation induced by 12-O-tetradecanoylphorbol-13-acetate be related to tumor promotion?
Topics: Animals; Cell Differentiation; Cells, Cultured; Cocarcinogenesis; DNA; Fishes; Genotype; Melanoma; Melanophores; Monophenol Monooxygenase; Phorbols; Protein Biosynthesis; Tetradecanoylphorbol Acetate | 1982 |
Effects of teleocidin and the phorbol ester tumor promoters on cell transformation, differentiation, and phospholipid metabolism.
Topics: Adenoviruses, Human; Alkaloids; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Choline; Humans; Lyngbya Toxins; Melanins; Melanoma; Mice; Muscles; Phorbols; Phospholipids; Rats; Tetradecanoylphorbol Acetate | 1982 |
Effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and its nonpromoting analogue 4-O-methyl-TPA on dorsal dermal melanocytes of the Syrian golden hamster (Mesocricetus auratus).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cricetinae; Female; Melanocytes; Melanoma; Mesocricetus; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Cell differentiation, alterations in polyamine levels, and specific binding of phorbol diesters in cultured human cells.
Topics: Binding Sites; Carcinogens; Cell Differentiation; Cell Line; Cell Membrane; Humans; Leukemia, Myeloid, Acute; Melanoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Polyamines; Tetradecanoylphorbol Acetate | 1982 |
Surface antigens of melanocytes and melanomas. Markers of melanocyte differentiation and melanoma subsets.
Topics: Adult; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Antigens, Surface; Cell Differentiation; Cell Transformation, Neoplastic; Cholera Toxin; Female; Humans; Infant, Newborn; Melanoma; Mice; Pregnancy; Skin; Tetradecanoylphorbol Acetate | 1982 |
A human melanoma cell line established from xenograft in athymic mice.
Topics: Animals; Cell Division; Cell Line; Dimethyl Sulfoxide; Humans; Isoenzymes; Karyotyping; Melanins; Melanoma; Mice; Mice, Nude; Microscopy, Electron; Neoplasm Transplantation; Neoplasms, Experimental; Tetradecanoylphorbol Acetate; Transplantation, Heterologous | 1980 |
Retinoic acid specifically increases nuclear PKC alpha and stimulates AP-1 transcriptional activity in B16 mouse melanoma cells.
Topics: Animals; Cell Differentiation; Cell Fractionation; Cell Membrane; Cell Nucleus; Intracellular Signaling Peptides and Proteins; Isoenzymes; Luciferases; Melanoma; Membrane Proteins; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Proteins; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic; Tretinoin; Tumor Cells, Cultured | 1995 |
Phorbol ester induced rapid attachment and spreading of melanoma cells and the role of extracellular matrix proteins.
Topics: Amino Acid Sequence; Cell Adhesion; Extracellular Matrix; Extracellular Matrix Proteins; Fibronectins; Humans; Integrins; Melanoma; Molecular Sequence Data; Naphthalenes; Oligopeptides; Polycyclic Compounds; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Defective lymphokine production by most CD8+ and CD4+ tumor-specific T cell clones derived from human melanoma-infiltrating lymphocytes in response to autologous tumor cells in vitro.
Topics: Antibodies, Monoclonal; Antigens, CD; CD3 Complex; CD4-Positive T-Lymphocytes; CD58 Antigens; CD8 Antigens; Cytokines; Humans; Interleukin-2; Ionophores; Lymphocytes, Tumor-Infiltrating; Melanoma; Membrane Glycoproteins; T-Lymphocyte Subsets; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1994 |
Ultraviolet radiation-induced melanogenesis in human melanocytes. Effects of modulating protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Diglycerides; Enzyme Induction; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Melanins; Melanocytes; Melanoma; Melanoma, Experimental; Membrane Proteins; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Neoplasm Proteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Proteins; Signal Transduction; Skin Neoplasms; Taurodeoxycholic Acid; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1994 |
Expression of protectin (CD59) in human melanoma and its functional role in cell- and complement-mediated cytotoxicity.
Topics: Antibodies, Monoclonal; Antibody-Dependent Cell Cytotoxicity; Antigens, CD; CD59 Antigens; Complement Inactivator Proteins; Cytokines; Cytotoxicity, Immunologic; Fluorescent Antibody Technique; Humans; Immunization; Immunoglobulin Fragments; Immunohistochemistry; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Melanoma; Membrane Glycoproteins; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; RNA, Messenger; Tetradecanoylphorbol Acetate | 1995 |
O-methylation of L-dopa in melanin metabolism and the presence of catechol-O-methyltransferase in melanocytes.
Topics: 1-Methyl-3-isobutylxanthine; Catechol O-Methyltransferase; Cells, Cultured; Humans; Isoenzymes; Levodopa; Melanins; Melanocytes; Melanoma; Membrane Proteins; Methylation; Microscopy, Immunoelectron; Monophenol Monooxygenase; Neoplasm Proteins; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Inhibition of the melanoma cell cycle and regulation at the G1/S transition by 12-O-tetradecanoylphorbol-13-acetate (TPA) by modulation of CDK2 activity.
Topics: CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cyclin D1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; G1 Phase; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Microtubule-Associated Proteins; Oncogene Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; RNA, Messenger; S Phase; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1995 |
In vitro characterization of Acanthamoeba castellanii cytopathic effect.
Topics: Acanthamoeba; Animals; Bepridil; Calcimycin; Calcium Channels; Cathepsin C; Cell Survival; Cytochalasin D; Cytoskeleton; Cytotoxicity, Immunologic; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Humans; Immunosuppressive Agents; Killer Cells, Lymphokine-Activated; Melanoma; Microscopy, Electron; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Uveal Neoplasms | 1995 |
Protein kinase C beta expression in melanoma cells and melanocytes: differential expression correlates with biological responses to 12-O-tetradecanoylphorbol 13-acetate.
Topics: Blotting, Northern; Blotting, Southern; Cell Division; Cells, Cultured; DNA; Down-Regulation; Gene Expression Regulation; Humans; Melanocytes; Melanoma; Protein Kinase C; RNA; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
A murine monoclonal antibody, MoAb HMSA-5, against a melanosomal component highly expressed in early stages, and common to normal and neoplastic melanocytes.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Cell Differentiation; Cells, Cultured; Epitopes; Glycosylation; Humans; Immunoglobulin G; Immunohistochemistry; Infant, Newborn; Male; Melanocytes; Melanoma; Mice; Microscopy, Immunoelectron; Monophenol Monooxygenase; Nevus; Precipitin Tests; Proteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Interleukin-1-inducible expression of gro-beta via NF-kappa B activation is dependent upon tyrosine kinase signaling.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cell Line; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Colforsin; Cytomegalovirus; Gene Expression; Gene Expression Regulation, Neoplastic; Genes, jun; Genes, myc; Genistein; Growth Substances; HeLa Cells; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-1; Isoflavones; L Cells; Melanoma; Mice; Molecular Sequence Data; NF-kappa B; Oligonucleotide Probes; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 1993 |
Elevated expression of protein tyrosine kinase c-Yes, but not c-Src, in human malignant melanoma.
Topics: Blotting, Western; Cell Transformation, Neoplastic; DNA Mutational Analysis; Humans; Melanocytes; Melanoma; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-yes; Proto-Oncogene Proteins pp60(c-src); Proto-Oncogenes; RNA, Messenger; src-Family Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
The urokinase-type plasminogen activator receptor, a GPI-linked protein, is localized in caveolae.
Topics: Caveolin 1; Caveolins; Cell Fractionation; Cell Membrane; Chromogenic Compounds; Filipin; Glycosylphosphatidylinositols; Humans; Melanoma; Membrane Proteins; Nystatin; Octoxynol; Oligopeptides; Plasminogen; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1995 |
Stimulation of the 92-kD type IV collagenase promoter and enzyme expression in human melanoma cells.
Topics: Base Sequence; Collagenases; Gene Expression Regulation, Neoplastic; Humans; Interleukin-1; Matrix Metalloproteinase 9; Melanoma; Molecular Sequence Data; Promoter Regions, Genetic; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Experimental metastasis and differentiation of murine melanoma cells: actions and interactions of factors affecting different intracellular signalling pathways.
Topics: Animals; Cell Differentiation; Cell Division; Cholera Toxin; Cyclic AMP; Female; H-2 Antigens; Hydrogen-Ion Concentration; In Vitro Techniques; Melanocyte-Stimulating Hormones; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Modulation of human melanoma cell metastasis and adhesion may involve integrin phosphorylation mediated through protein kinase C.
Topics: Amino Acids; Animals; Cell Adhesion; Cell Line; Collagen; Fibronectins; Humans; Integrins; Laminin; Lung Neoplasms; Melanoma; Mice; Mice, SCID; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Transplantation, Heterologous; Tumor Cells, Cultured | 1994 |
Modification of invasion and differentiation in human melanoma cell clones.
Topics: Cell Survival; Cell Transformation, Neoplastic; Chemotaxis; Doxorubicin; Humans; Melanoma; Neoplasm Invasiveness; Plasminogen Activators; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1994 |
Different biological effects of the two protein kinase C activators bryostatin-1 and TPA on human carcinoma cell lines.
Topics: Adenocarcinoma; Antineoplastic Agents; Bryostatins; Cell Division; Cell Survival; DNA; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; Lactones; Macrolides; Melanoma; Protein Kinase C; Proto-Oncogene Proteins c-myc; RNA, Messenger; Sigmoid Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 1994 |
A novel regulatory sequence affecting the constitutive expression of tissue plasminogen activator (tPA) gene in human melanoma (Bowes) cells.
Topics: Base Sequence; Binding Sites; Blotting, Northern; Blotting, Southern; Cell Line; Chloramphenicol O-Acetyltransferase; Cloning, Molecular; Dexamethasone; DNA-Binding Proteins; Enhancer Elements, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Library; HeLa Cells; Humans; Melanoma; Placenta; Pregnancy; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator; Transfection; Tumor Cells, Cultured | 1994 |
Effect of protein kinase C inhibitors on invasiveness of human melanoma clones expressing different levels of protein kinase C isoenzymes.
Topics: Alkaloids; Cell Movement; Diglycerides; Humans; Isoenzymes; Melanoma; Neoplasm Invasiveness; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Growth inhibition of human melanoma-derived cells by 12-O-tetradecanoyl phorbol 13-acetate.
Topics: Cell Division; Cell Transformation, Neoplastic; Down-Regulation; Humans; Isoenzymes; Melanoma; Protein Kinase C; Sensitivity and Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Differential regulation of gelatinase B and tissue-type plasminogen activator expression in human Bowes melanoma cells.
Topics: Cell Compartmentation; Collagenases; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, jun; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Melanoma; Metalloendopeptidases; Peptide Elongation Factors; Protein Kinase C; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Time Factors; Tissue Plasminogen Activator | 1993 |
Tamoxifen modulation of cisplatin sensitivity in human malignant melanoma cells.
Topics: Antineoplastic Agents; Calmodulin; Cell Cycle; Cisplatin; Drug Resistance; Drug Synergism; Enzyme Induction; Humans; Melanoma; Protein Kinase C; Receptors, Estrogen; Sulfonamides; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1993 |
Deletion of specific protein kinase C subspecies in human melanoma cells.
Topics: Cell Division; Chromatography; Durapatite; Humans; Immunoblotting; Isoenzymes; Melanocytes; Melanoma; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
The expression of integrin alpha 2 beta 1 and attachment to type I collagen of melanoma cells are preferentially induced by tumour promoter, TPA (12-O-tetradecanoyl phorbol-13-acetate).
Topics: Carcinogens; Cell Adhesion; Cell Separation; Collagen; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Integrin beta1; Melanoma; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Alterations in endothelial cell proteinase and inhibitor polarized secretion following treatment with interleukin-1, phorbol ester, and human melanoma cell conditioned medium.
Topics: Animals; Aorta; Cells, Cultured; Collagen; Culture Media, Conditioned; Endothelium, Vascular; Haplorhini; Humans; Interleukin-1; Melanoma; Metalloendopeptidases; Recombinant Proteins; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator | 1996 |
The pleiotropic effect of TPA on in vitro invasion/migration of glioma and melanoma cell lines.
Topics: Animals; Carcinogens; Cell Movement; Down-Regulation; Glioma; Humans; Isoenzymes; Melanoma; Neoplasm Invasiveness; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Interleukin-1-induced growth inhibition of human melanoma cells. Interleukin-1-induced antizyme expression is responsible for ornithine decarboxylase activity down-regulation.
Topics: Cell Division; Down-Regulation; Enzyme Inhibitors; Humans; Interleukin-1; Melanoma; Oligonucleotides, Antisense; Ornithine Decarboxylase; Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1997 |
The high affinity alphaIIb beta3 integrin is involved in invasion of human melanoma cells.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adult; Antibodies, Monoclonal; Blotting, Northern; Blotting, Southern; Cell Adhesion; Epitopes; Female; Fibronectins; Fluorescent Antibody Technique, Indirect; Humans; Immunohistochemistry; Melanoma; Microscopy, Confocal; Neoplasm Invasiveness; Oligopeptides; Platelet Glycoprotein GPIIb-IIIa Complex; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Interrelation of motility, cytoskeletal organization and gap junctional communication with invasiveness of melanocytic cells in vitro.
Topics: Actins; Animals; Cell Communication; Cell Division; Cell Movement; Chick Embryo; Cholera Toxin; Culture Media, Serum-Free; Cytoskeleton; Gap Junctions; Heart; Image Processing, Computer-Assisted; Melanocytes; Melanoma; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mitogens; Neoplasm Invasiveness; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vinculin | 1997 |
Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Cells, Cultured; Cytokines; Ephrin-B2; Gene Expression Regulation, Neoplastic; Humans; Infant, Newborn; Melanocytes; Melanoma; Membrane Proteins; Mice; Mice, Nude; Neoplasm Metastasis; Nevus, Pigmented; Polymerase Chain Reaction; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transplantation, Heterologous; Tumor Cells, Cultured; Ultraviolet Rays | 1998 |
Regulation of the cell cycle at the G2/M boundary in metastatic melanoma cells by 12-O-tetradecanoyl phorbol-13-acetate (TPA) by blocking p34cdc2 kinase activity.
Topics: CDC2 Protein Kinase; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Membrane; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Cytoplasm; Cytosol; Enzyme Inhibitors; G2 Phase; Humans; Intracellular Membranes; Isoenzymes; Melanoma; Microtubule-Associated Proteins; Mitosis; Protein Kinase C; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1998 |
Regulation of expression of MSG1 melanocyte-specific nuclear protein in human melanocytes and melanoma cells.
Topics: Apoptosis Regulatory Proteins; Carcinogens; Cells, Cultured; Culture Media; Enzyme Activation; Fibroblast Growth Factor 2; Gene Expression; Gene Expression Regulation; Humans; Melanocytes; Melanoma; Nuclear Proteins; Promoter Regions, Genetic; Protein Kinase C; RNA, Messenger; Skin; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 1998 |
Apoptosis induced by hydrogen peroxide is mediated by decreased superoxide anion concentration and reduction of intracellular milieu.
Topics: Apoptosis; Blotting, Western; Caspase Inhibitors; Caspases; Dose-Response Relationship, Drug; Enzyme Activation; Fluoresceins; Glutathione; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Melanoma; NADH, NADPH Oxidoreductases; Necrosis; Oxidation-Reduction; Poly(ADP-ribose) Polymerases; RNA, Antisense; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1998 |
UVB-specific regulation of gene expression in human melanocytic cells: cell cycle effects and implication in the generation of melanoma.
Topics: Antineoplastic Agents; beta-Galactosidase; Cell Cycle; Cisplatin; Demecolcine; Genes, fos; Genes, p53; HeLa Cells; HIV Long Terminal Repeat; Humans; Hydroxyurea; Inosine; Melanocytes; Melanoma; Methylnitronitrosoguanidine; Neoplasms, Radiation-Induced; Nitrosourea Compounds; Organophosphorus Compounds; Proto-Oncogene Proteins c-fos; Recombinant Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Ultraviolet Rays | 1998 |
Role of microphthalmia transcription factor in regulation of melanocyte differentiation marker TRP-1.
Topics: Acetamides; Blotting, Western; Cell Nucleus; Cell Size; Cholera Toxin; Cycloheximide; Dactinomycin; DNA-Binding Proteins; Down-Regulation; Gene Expression Regulation; Half-Life; Humans; Melanins; Melanocytes; Melanoma; Membrane Glycoproteins; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Oxidoreductases; Protein Biosynthesis; Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 1999 |
Opposite effects of TPA on G1/S transition and on cell size in the low metastatic B16F1 with respect to high metastatic BL6 murine melanoma cells.
Topics: Animals; Carcinogens; Cell Cycle; Cell Size; Enzyme Activation; G1 Phase; Melanoma; Mice; Neoplasm Metastasis; Protein Kinase C; S Phase; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Induction of melanoma in TPras transgenic mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Albinism; Animals; Carcinoma; Gene Expression Regulation; Genes, ras; Genetic Predisposition to Disease; Hair Color; Hyperplasia; Melanocytes; Melanoma; Mice; Mice, SCID; Mice, Transgenic; Monophenol Monooxygenase; Neoplasm Metastasis; Neoplasms, Radiation-Induced; Papilloma; Promoter Regions, Genetic; Skin Neoplasms; Skin Pigmentation; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1999 |
Detection of human soluble Thy-1 in serum by ELISA. Fibroblasts and activated endothelial cells are a possible source of soluble Thy-1 in serum.
Topics: Arthritis, Rheumatoid; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Humans; Immunohistochemistry; Intercellular Adhesion Molecule-1; Male; Melanoma; Platelet Endothelial Cell Adhesion Molecule-1; Recombinant Proteins; Skin; Skin Neoplasms; Synovial Membrane; Tetradecanoylphorbol Acetate; Thy-1 Antigens; Tumor Necrosis Factor-alpha; Varicose Ulcer | 1999 |
Activation of integrin alpha(V)beta(3) regulates cell adhesion and migration to bone sialoprotein.
Topics: Cell Adhesion; Cell Line; Cells, Cultured; Chemotaxis; Endothelium, Vascular; Humans; Integrin-Binding Sialoprotein; Lymphocytes; Manganese; Melanoma; Oligopeptides; Osteoblasts; Receptors, Vitronectin; Sialoglycoproteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Umbilical Veins | 2000 |
Evaluation of the modified ELISPOT assay for gamma interferon production in cancer patients receiving antitumor vaccines.
Topics: Antibodies, Monoclonal; Antigens, Neoplasm; Biological Assay; Cancer Vaccines; Cell Line; Clinical Trials as Topic; Evaluation Studies as Topic; gp100 Melanoma Antigen; Humans; Interferon-gamma; Ionomycin; Leukocytes, Mononuclear; MART-1 Antigen; Melanoma; Membrane Glycoproteins; Monophenol Monooxygenase; Neoplasm Proteins; Reproducibility of Results; Sensitivity and Specificity; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vaccines, Synthetic | 2000 |
Release of active tissue factor by human arterial smooth muscle cells.
Topics: Aorta; Cells, Cultured; Coronary Vessels; Humans; Indomethacin; Interleukin-1; Kinetics; Melanoma; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Recombinant Proteins; Tetradecanoylphorbol Acetate; Thromboplastin; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2000 |
Thioredoxin, thioredoxin reductase and tumour necrosis factor-alpha expression in melanoma cells: correlation to resistance against cytotoxic attack.
Topics: Cell Survival; Drug Combinations; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Humans; Immunoenzyme Techniques; Interferon-gamma; Interleukins; Lymph Nodes; Lymphatic Metastasis; Melanocytes; Melanoma; Microscopy, Confocal; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thioredoxin-Disulfide Reductase; Thioredoxins; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; U937 Cells | 2000 |
Survival mechanisms induced by 12-O-tetradecanoylphorbol-13-acetate in normal human melanocytes include inhibition of apoptosis and increased Bcl-2 expression.
Topics: Annexin A5; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Cell Survival; Cells, Cultured; Humans; Infant, Newborn; Kinetics; Male; Melanocytes; Melanoma; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Skin; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 2000 |
Expression of microtubule-associated protein 2 in benign and malignant melanocytes: implications for differentiation and progression of cutaneous melanoma.
Topics: Acetamides; Biomarkers; Cell Differentiation; Cell Line; Cyclic AMP; Disease Progression; Gene Expression Profiling; Humans; Melanocytes; Melanoma; Microtubule-Associated Proteins; RNA, Messenger; RNA, Neoplasm; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 2001 |
The Gem GTP-binding protein promotes morphological differentiation in neuroblastoma.
Topics: Animals; Carbachol; Cell Differentiation; Cholinergic Agonists; Ganglioneuroblastoma; Humans; Immediate-Early Proteins; Melanoma; Mice; Monomeric GTP-Binding Proteins; Neoplasm Proteins; Neuroblastoma; Receptors, Muscarinic; Tetradecanoylphorbol Acetate; Trigeminal Ganglion; Tumor Cells, Cultured | 2001 |
Biphasic response to human galanin of extracellular acidification in human Bowes melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Acids; Amiloride; Cell Line; Colforsin; Dose-Response Relationship, Drug; Extracellular Space; Galanin; Gene Expression; Humans; Hydrogen-Ion Concentration; Melanoma; Peptide Fragments; Pertussis Toxin; Receptors, Galanin; Receptors, Neuropeptide; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 2001 |
Different levels of TGFbeta, IL-10, IFNgamma and gelatinase A occur in experimental white and black metastases induced by bryostatin 1 or by phorbol ester-treated BL6T murine melanoma cells.
Topics: Animals; Antineoplastic Agents; Bryostatins; Interferon-gamma; Interleukin-10; L-Lactate Dehydrogenase; Lactones; Lung Neoplasms; Macrolides; Matrix Metalloproteinase 2; Melanoma; Mice; Mice, Inbred C57BL; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 2000 |
Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties.
Topics: Antigens, Neoplasm; Apoptosis; Base Sequence; Carcinoma; Cell Differentiation; Cell Division; Chromosomes, Human, Pair 1; Cloning, Molecular; Dimethyl Sulfoxide; Diterpenes; Female; Gene Expression Regulation, Neoplastic; Genes; Genes, Tumor Suppressor; Glioblastoma; Growth Substances; HL-60 Cells; Humans; Interferon Type I; Interleukins; K562 Cells; Male; Melanocytes; Melanoma; Molecular Sequence Data; Molecular Weight; Neoplasm Proteins; Neoplasms; Organ Specificity; Osteosarcoma; Recombinant Fusion Proteins; Recombinant Proteins; RNA, Messenger; RNA, Neoplasm; Terpenes; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 2001 |
Role of zyxin in differential cell spreading and proliferation of melanoma cells and melanocytes.
Topics: Cell Differentiation; Cell Division; Cells, Cultured; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glycoproteins; Humans; Melanocytes; Melanoma; Metalloproteins; Paxillin; Phenotype; Phosphoproteins; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Zyxin | 2002 |
Dual regulation of phospholipase D1 by protein kinase C alpha in vivo.
Topics: Animals; Cell Line; Cells, Cultured; Enzyme Activation; Humans; Isoenzymes; Melanocytes; Melanoma; Phospholipase D; Phosphorylation; Protein Isoforms; Protein Kinase C; Protein Kinase C-alpha; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2002 |
Stimulation of differentiated functions in human melanoma cells by tumor-promoting agents and dimethyl sulfoxide.
Topics: Cell Differentiation; Cell Division; Cells, Cultured; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Gangliosides; Humans; Melanins; Melanoma; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1979 |
Effect of phorbol ester tumor promoters on the expression of melanogenesis in B-16 melanoma cells.
Topics: Animals; Cell Differentiation; Clone Cells; Melanins; Melanocyte-Stimulating Hormones; Melanoma; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1979 |
The expression of functional MSH receptors on cultured human melanocytes.
Topics: alpha-MSH; Animals; Cells, Cultured; Cholera Toxin; Cyclic AMP; Fibroblasts; Humans; Keratinocytes; Melanocytes; Melanoma; Mice; Receptors, Pituitary Hormone; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Heterogeneity of cytokine production by human malignant melanoma cells.
Topics: Cytokines; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-1; Interleukin-6; Melanoma; Platelet-Derived Growth Factor; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Expression and chromosomal localization of the gene for the human transcriptional repressor GCF.
Topics: Animals; Blotting, Northern; Chromosome Banding; Chromosome Mapping; Chromosomes, Human, Pair 1; Clone Cells; Humans; Karyotyping; KB Cells; Melanoma; Plasmacytoma; Repressor Proteins; Restriction Mapping; RNA; RNA Probes; RNA, Messenger; RNA, Neoplasm; Stomach Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Phorbol 12-myristate 13-acetate induces resistance of human melanoma cells to natural-killer- and lymphokine-activated-killer-mediated cytotoxicity.
Topics: Cell Adhesion Molecules; Cell Differentiation; Cell Division; Cell Membrane; Cell Polarity; Collagen; Cytotoxicity, Immunologic; HLA Antigens; Humans; Intercellular Adhesion Molecule-1; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Melanoma; Receptors, Immunologic; Receptors, Vitronectin; S100 Proteins; Synaptophysin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
12-O-tetradecanoylphorbol-13-acetate induces transient cell cycle arrest in G1 and G2 in metastatic melanoma cells: inhibition of phosphorylation of p34cdc2.
Topics: Breast Neoplasms; CDC2 Protein Kinase; Cell Division; Depression, Chemical; DNA Replication; Humans; Interphase; Male; Melanoma; Middle Aged; Neoplasm Proteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Interleukin-6 production by human melanoma cell lines.
Topics: Blotting, Northern; Cell Line; DNA Replication; Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-1; Interleukin-6; Melanoma; Recombinant Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Thymidine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1992 |
Malignant transformation of human melanocytes: induction of a complete melanoma phenotype and genotype.
Topics: 3T3 Cells; Animals; Antigens, Surface; Cell Transformation, Neoplastic; Chromosome Aberrations; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 6; Genes, ras; Genotype; HLA-DR Antigens; Humans; Melanocytes; Melanoma; Mice; Phenotype; Tetradecanoylphorbol Acetate | 1992 |
Comparison of calmodulin gene expression in human neonatal melanocytes and metastatic melanoma cell lines.
Topics: Culture Media, Serum-Free; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Growth Substances; Humans; Infant, Newborn; Male; Melanocytes; Melanoma; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1992 |
Monoclonal anti-melanoma antibodies IKH-1 and IKH-2 which work on formalin-fixed, paraffin embedded tissues: characterization, clinical trials and comparative studies with HMB-45.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Biomarkers, Tumor; Cell Transformation, Neoplastic; Clinical Trials as Topic; Formaldehyde; Humans; Hybridomas; Immunohistochemistry; Melanoma; Melanoma, Experimental; Mice; Microscopy, Immunoelectron; Paraffin; Tetradecanoylphorbol Acetate; Tissue Fixation; Tumor Cells, Cultured | 1992 |
Effect of tumour necrosis factor alpha in vivo on human granulocyte oxidative metabolism.
Topics: Acridines; Amino Acid Sequence; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Luminescent Measurements; Lymphotoxin-alpha; Melanoma; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidation-Reduction; Recombinant Proteins; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Zymosan | 1991 |
Identification and characterization of a low-affinity granulocyte-macrophage colony-stimulating factor receptor on primary and cultured human melanoma cells.
Topics: Cell Line; Cells, Cultured; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Kinetics; Melanoma; Neoplasm Metastasis; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Recombinant Proteins; Tetradecanoylphorbol Acetate | 1991 |
A novel approach to analysis of transcriptional regulation in human cells: initial application to melanocytes and melanoma cells.
Topics: Actins; beta-Galactosidase; Cells, Cultured; Glucuronidase; Humans; Melanocytes; Melanoma; Simian virus 40; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1991 |
Induction of cell differentiation in melanoma cells by inhibitors of IMP dehydrogenase: altered patterns of IMP dehydrogenase expression and activity.
Topics: Biomarkers; Gene Expression Regulation, Neoplastic; Guanosine; Humans; IMP Dehydrogenase; Melanins; Melanoma; Monophenol Monooxygenase; Mycophenolic Acid; Neoplasm Proteins; Ribavirin; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1990 |
The differential expression of protein kinase C genes in normal human neonatal melanocytes and metastatic melanomas.
Topics: Gene Expression; Humans; Infant, Newborn; Isoenzymes; Melanocytes; Melanoma; Neoplasm Metastasis; Protein Kinase C; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1991 |
Independent expression and cellular processing of Mr 72,000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines.
Topics: Blotting, Western; Culture Media; Enzyme Precursors; Extracellular Space; Fibrosarcoma; Humans; Melanoma; Microbial Collagenase; Molecular Weight; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Positive and negative regulation of a tumor necrosis factor response in melanoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; DNA Probes; Female; Humans; Isoquinolines; Kinetics; Melanoma; Phorbol 12,13-Dibutyrate; Piperazines; Plasminogen Activators; Plasminogen Inactivators; Pregnancy; Protein Kinase Inhibitors; Recombinant Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1990 |
Tumor necrosis factor enhances GD3 ganglioside expression in cultured human melanocytes.
Topics: Antibodies, Monoclonal; Cells, Cultured; Gangliosides; Humans; Infant, Newborn; Melanocytes; Melanoma; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1990 |
Differential expression of protein kinase C and cAMP-dependent protein kinase in normal human melanocytes and malignant melanomas.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Blotting, Southern; Cell Division; Humans; Isoquinolines; Melanocytes; Melanoma; Piperazines; Protein Kinase C; Protein Kinases; RNA, Messenger; Tetradecanoylphorbol Acetate | 1990 |
Human melanocytes cultured from nevi and melanomas.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Cell Division; Cell Separation; Cells, Cultured; Child; Cholera Toxin; Female; Humans; Infant, Newborn; Male; Melanocytes; Melanoma; Middle Aged; Nevus; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Class II histocompatibility antigen expression in human melanocytes transformed by Harvey murine sarcoma virus (Ha-MSV) and Kirsten MSV retroviruses.
Topics: Cell Division; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Harvey murine sarcoma virus; Histocompatibility Antigens Class II; Humans; Interferon-gamma; Kirsten murine sarcoma virus; Melanocytes; Melanoma; Oncogenes; RNA; Tetradecanoylphorbol Acetate | 1986 |
Nerve growth factor receptors in chromatin of melanoma cells, proliferating melanocytes, and colorectal carcinoma cells in vitro.
Topics: Cell Division; Cell Line; Chromatin; Colorectal Neoplasms; Deoxyribonuclease EcoRI; Endodeoxyribonucleases; Fluorescent Antibody Technique; Humans; Kinetics; Melanocytes; Melanoma; Molecular Weight; Receptors, Cell Surface; Receptors, Nerve Growth Factor; RNA; Tetradecanoylphorbol Acetate | 1988 |
Phorbol ester-mediated down-regulation of an interferon-inducible gene.
Topics: Cycloheximide; Fibroblasts; Gene Expression Regulation; Humans; Interferon Type I; Melanoma; Phorbol 12,13-Dibutyrate; Recombinant Proteins; RNA; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1989 |
Phorbol ester impairs melanotropin receptor function and stimulates growth of cultured M2R melanoma cells.
Topics: Animals; Cells, Cultured; Colforsin; Cyclic AMP; Iodine Radioisotopes; Melanocyte-Stimulating Hormones; Melanoma; Mice; Phorbol Esters; Proteins; Receptors, Pituitary Hormone; Tetradecanoylphorbol Acetate | 1989 |
In vitro differentiation and antigenic changes in human melanoma cell lines.
Topics: Adjuvants, Immunologic; Antigens, Neoplasm; Cell Differentiation; Cell Line; Dose-Response Relationship, Immunologic; HLA Antigens; Humans; Interferon Type I; Melanoma; Melanoma-Specific Antigens; Neoplasm Proteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Induction of tumorigenicity and lack of in vitro growth requirement for 12-O-tetradecanoylphorbol-13-acetate by transfection of murine melanocytes with v-Ha-ras.
Topics: Animals; Blotting, Northern; Cell Line; Genes, ras; Leukemia, Experimental; Melanocytes; Melanoma; Mice; Molecular Weight; Phosphorylation; Protein Kinase C; Repetitive Sequences, Nucleic Acid; Tetradecanoylphorbol Acetate; Transfection | 1989 |
Inhibition of neuroglandular antigen (NGA) glycosylation by phorbol ester in human melanoma cells.
Topics: Antigens, Neoplasm; Biological Transport; Cell Membrane; Clomiphene; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Glycosylation; Humans; Immunosorbent Techniques; Melanoma; Melanoma-Specific Antigens; Molecular Weight; Neoplasm Proteins; Phloretin; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Regulation of cell differentiation and tumor promotion by 1 alpha,25 dihydroxyvitamin D3.
Topics: Animals; Calcitriol; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Enzyme Induction; Humans; Lymphocytes; Melanins; Melanoma; Mice; Ornithine Decarboxylase; Protein Kinase C; Receptors, Calcitriol; Receptors, Steroid; Skin; Tetradecanoylphorbol Acetate | 1985 |
Regulation of cell shape in the Cloudman melanoma cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-MSH; Animals; Axons; Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; Fluorescent Antibody Technique; Isoquinolines; Melanocyte-Stimulating Hormones; Melanoma; Mice; Microscopy, Electron; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic | 1987 |
Activation of human monocyte tumoricidal activity by C-reactive protein.
Topics: Astrocytes; Astrocytoma; C-Reactive Protein; Carcinoma, Renal Cell; Cell Line; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immunologic; Fibroblasts; Humans; Kidney Neoplasms; Melanoma; Monocytes; Phosphorylcholine; Superoxides; Tetradecanoylphorbol Acetate | 1987 |
Induction of differentiation as a means of modifying metastatic behaviour.
Topics: Animals; Cell Differentiation; Cell Line; Humans; Lipopolysaccharides; Lymphoma, Large B-Cell, Diffuse; Melanoma; Neoplasm Metastasis; Tetradecanoylphorbol Acetate | 1988 |
Histogenesis of the intradermal melanocytic tumor in BDF1 mice induced by topical application of 9,10-dimethyl-1,2-benzanthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Melanocytes; Melanoma; Mice; Mice, Inbred Strains; Microscopy, Electron; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Messenger RNA for a phorbol-ester induced 48,000 dalton protein from human melanoma cells.
Topics: Animals; Autoradiography; Cell Line; Centrifugation, Density Gradient; Humans; Melanoma; Molecular Weight; Oocytes; Phorbol Esters; Protein Biosynthesis; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Tissue Plasminogen Activator; Xenopus | 1986 |
Phorbol ester stimulates the synthesis and phosphorylation of a 48 kDa-intracellular protein in plasminogen activator secreting melanoma cells.
Topics: Cell Line; Cytosol; Humans; Melanoma; Molecular Weight; Neoplasm Proteins; Phorbols; Phosphoproteins; Phosphorylation; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator | 1986 |
Phorbol-induced recruitment of lymphocytes for spontaneous cytolysis of natural killer-insensitive tumor targets.
Topics: Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Cell Membrane; Cytotoxicity, Immunologic; Fibroblasts; Freeze Fracturing; Humans; Killer Cells, Natural; Melanoma; Membrane Proteins; Microscopy, Electron; Neoplasms; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate | 1986 |
A line of non-tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growth.
Topics: Animals; Cell Division; Cell Line; Hydrogen-Ion Concentration; Lyngbya Toxins; Melanocytes; Melanoma; Mice; Mice, Inbred BALB C; Tetradecanoylphorbol Acetate | 1987 |
Phenotypic heterogeneity of melanoma. Relation to the differentiation program of melanoma cells.
Topics: Antigens, Neoplasm; Cell Differentiation; Cell Line; Cholera Toxin; Clone Cells; Humans; Melanoma; Monophenol Monooxygenase; Phenotype; Pigmentation; Tetradecanoylphorbol Acetate | 1987 |
Differences between the F10, BL6 and F1 sublines of the B16 melanoma in the enhancement of plasminogen activator and plasminogen activator inhibitor secretion by phorbol myristate acetate.
Topics: Animals; Cell Line; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Melanoma; Mice; Neoplasm Metastasis; Plasminogen Activators; Plasminogen Inactivators; Tetradecanoylphorbol Acetate; Urokinase-Type Plasminogen Activator | 1987 |
Extracellular matrix modulates the function of human melanocytes but not melanoma cells.
Topics: Cell Division; Cells, Cultured; Cholera Toxin; Culture Media; Extracellular Matrix; Humans; Melanocytes; Melanoma; Monophenol Monooxygenase; Tetradecanoylphorbol Acetate | 1988 |
Heterogeneity of the response to inducers of differentiation and to cytostatics of tumor cell populations.
Topics: Antineoplastic Agents; Cell Differentiation; Cisplatin; Cytarabine; Dacarbazine; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Doxorubicin; Fluorouracil; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Promyelocytic, Acute; Melanoma; Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1988 |
Increased ornithine decarboxylase activity in cultured cells exposed to low energy modulated microwave fields and phorbol ester tumor promoters.
Topics: Animals; Cells, Cultured; Cricetinae; Cricetulus; Liver Neoplasms, Experimental; Melanoma; Microwaves; Ornithine Decarboxylase; Phorbol Esters; Tetradecanoylphorbol Acetate | 1988 |
Phorbol ester-induced loss of cell surface sialic acid enhances target cell sensitivity to cytolysis by natural killer (NK) cells.
Topics: Cell Line; Cell Membrane; Cytotoxicity, Immunologic; Freeze Fracturing; Humans; Killer Cells, Natural; Leukemia, Myeloid; Melanoma; Microscopy, Electron; Sialic Acids; Tetradecanoylphorbol Acetate | 1987 |
Human melanoma proteoglycan: expression in hybrids controlled by intrinsic and extrinsic signals.
Topics: Aggrecans; Animals; Antibodies, Monoclonal; Cell Line; Cholera Toxin; Chromosome Mapping; Chromosomes, Human, 13-15; Cricetinae; Cricetulus; Extracellular Matrix Proteins; Gene Expression Regulation; Glycoproteins; Humans; Hybrid Cells; Lectins, C-Type; Lymphocytes; Melanocytes; Melanoma; Mice; Neoplasm Proteins; Neuroblastoma; Proteoglycans; Rats; Tetradecanoylphorbol Acetate | 1986 |
Differing patterns of cytotoxicity of the phorbol ester 12-O-tetradecanoylphorbol 13-acetate in various human cell strains.
Topics: Breast Neoplasms; Cell Line; Cell Survival; Female; Fibroblasts; Humans; Kinetics; Male; Melanoma; Osteosarcoma; Phorbols; Prostatic Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Correlation of murine susceptibility to tumor, parasite and bacterial challenge with altered cell-mediated immunity following systemic exposure to the tumor promoter phorbol myristate acetate.
Topics: Animals; Cell Line; Cytotoxicity, Immunologic; Female; Immunity, Cellular; Immunity, Innate; Killer Cells, Natural; Listeriosis; Macrophage Activation; Melanoma; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Phorbols; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate; Trichinellosis | 1985 |
In vitro differentiation of human melanoma cells analyzed with monoclonal antibodies.
Topics: Antibodies, Monoclonal; Antigens, Neoplasm; Antigens, Surface; Cell Line; Cell Transformation, Neoplastic; Humans; Melanins; Melanoma; Tetradecanoylphorbol Acetate | 1985 |
Growth regulation of human melanocytes: mitogenic factors in extracts of melanoma, astrocytoma, and fibroblast cell lines.
Topics: Astrocytoma; Cell Division; Cell Line; Cholera Toxin; Fibroblasts; Growth Substances; Humans; Melanocytes; Melanoma; Tetradecanoylphorbol Acetate | 1985 |