tetradecanoylphorbol acetate has been researched along with Invasiveness, Neoplasm in 181 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (2.76) | 18.7374 |
| 1990's | 43 (23.76) | 18.2507 |
| 2000's | 55 (30.39) | 29.6817 |
| 2010's | 74 (40.88) | 24.3611 |
| 2020's | 4 (2.21) | 2.80 |
| Authors | Studies |
|---|---|
| Hong, OY; Jang, HY; Jung, SH; Kim, JS; Lee, YR; Youn, HJ | 1 |
| Baek, J; Kim, S; Lee, KS; Nam, GS; Nam, KS | 1 |
| Chou, YE; Hsiao, YH; Hsin, MC; Lee, CY; Lin, CW; Wang, PH; Yang, SF | 1 |
| Jung, SH; Kang, SY; Kim, JM; Kim, JS; Lee, YR; Noh, EM; Park, BH; Park, J; Song, HK; Youn, HJ | 1 |
| Du, Z; Fang, Z; Lan, B; Li, E; Liao, L; Meng, L; Shen, J; Wang, M; Wu, B; Wu, J; Xie, W; Xu, L; Xu, X; Zhu, T | 1 |
| Chew, EH; Chui, WK; Gan, FF; Hadadi, E; Karuppasamy, M; Ng, HL; Ong, SM; Seah, W; Wong, SC; Yeap, WH; Zhang, R | 1 |
| Koontongkaew, S; Pugdee, K; Utispan, K | 1 |
| Bak, Y; Kim, SJ; Oh, SR; Pham, TH; Ryu, HW; Yoon, DY | 1 |
| Asfaha, S; Boland, K; Gordon, D; Jin, G; Johnson, K; Lad, S; Londono, D; Morris, RJ; Park, H; Patterson, KS; Readio, N; Singh, A; Trempus, C; Wang, TC; Yang, X | 1 |
| Choi, JH; Chung, YC; Han, EH; Hwang, YP; Jeong, HG; Jin, SW; Kang, KW; Kim, HG; Kim, SK; Lee, GH | 1 |
| Chen, PN; Chiou, HL; Chou, MC; Hsieh, YH; Hung, CY; Lee, CH; Lin, CL; Lin, MT | 1 |
| García-Mata, R; Goicoechea, SM; Hwang, RF; Kim, HJ; McCulloch, CG; Otey, CA; Sharek, L; Staub, J; Urrutia, R; Valdivia, A; Yeh, JJ | 1 |
| Chao, CY; Chen, HW; Hsu, YT; Li, CC; Lii, CK; Liu, KL; Lu, CY | 1 |
| Chen, MK; Chuang, CY; Ho, HY; Hsieh, YH; Hsin, CH; Lin, CW; Lin, HP; Wu, BC; Yang, SF | 1 |
| Huang, JA; Liu, SQ; Qin, MB; Su, YJ; Tang, GD | 1 |
| Jin, ML; Kim, YH; Lee, SJ; Park, G; Park, SY | 1 |
| Cui, MN; Kim, HY; Lee, JH; Lee, YD; Oh, IH; Yoon, HH | 1 |
| Chen, BC; Kao, ST; Liu, CJ; Wang, SD; Yeh, CC | 1 |
| Chen, Q; Li, M; Li, W; Luo, Q; Miao, M; Qin, L; Shen, Y; Su, X; Yu, C | 1 |
| Chang, L; Drachenberg, DM; Klos, KS; Leung, CT; Luxton, GW; Schwertfeger, KL; Warmka, JK; Wattenberg, EV | 1 |
| Hwang, HY; Hwang, JK; Jung, SH; Kim, HJ; Kim, JM; Kim, JS; Kim, MS; Kwon, KB; Lee, YR; Noh, EM; Ryu, DG; You, YO; Youn, HJ; Yu, HN | 1 |
| Chen, XP; Li, T; Lu, JJ; Wang, YT; Wu, GS; Xu, WS | 1 |
| Jang, EH; Jang, SY; Jeong, SY; Kim, JH; Lee, JK | 1 |
| Chen, X; Tan, W; Wang, Y; Zhong, Z | 1 |
| Guo, S; He, X; Lan, H; Lan, T; Li, J; Li, W; Qi, C; Wang, L; Wei, P; Yang, Y; Ye, J; Zhang, Q | 1 |
| Hwang, JK; Kim, HJ; Kim, HR; Kim, JM; Kim, MS; Kim, YC; Kwon, KB; Lee, DS; Lee, YR; Moon, BS; Oh, H; Park, YJ; Rhee, YJ; Ryu, DG; Yang, SH; Yun, JM | 1 |
| Hou, YC; Li, CC; Yeh, CL; Yeh, SL | 1 |
| Adada, M; Hannun, YA; Kitatani, K; Newcomb, B; Obeid, LM; Perry, DM; Roddy, P; Siskind, L; Wu, BX | 1 |
| Dong, S; Guo, D; Li, L; Qi, B; Wang, Y; Yu, M; Yuan, D; Zhang, C | 1 |
| Chen, CT; Chen, MK; Chou, MY; Chuang, YT; Hsieh, YH; Lin, CW; Lin, FY; Tang, CH; Yang, SF | 1 |
| Jang, SW; Kang, H; Pak, JH; Shim, S | 1 |
| Liu, CJ; Yeh, CC; Yen, HR | 1 |
| Hong, OY; Jung, SH; Kim, JS; Lee, YR; Noh, EM; Youn, HJ | 1 |
| Choi, KB; Hong, OY; Kim, HR; Kim, JM; Kim, JS; Kim, MS; Kwon, KB; Lee, YR; Noh, EM; Park, SH; Park, YJ; So, HS; Song, HK; Yang, SH; You, YO; Youn, HJ | 1 |
| Bao, R; Bechill, J; Bindokas, VP; Faber, PW; Lingen, MW; Spiotto, MT; Zhong, R | 1 |
| Hiraishi, H; Horii, Y; Makiyama, T; Sai, XB; Sakane, H; Shirataki, H | 1 |
| Kim, HR; Kim, JM; Kim, MS; Kwon, KB; Lee, GS; Lee, M; Lee, YR; Moon, HC; Noh, EM; Song, HK; Yang, SH | 1 |
| Chen, Y; Li, D; Peng, F; Tang, M; Zhong, Y; Zhou, G | 1 |
| Chen, YC; Hou, WC; Juan, SH; Ko, CH; Lin, CW; Shen, SC; Wang, LM | 1 |
| Chen, YW; Fodstad, O; Tekle, C | 1 |
| Davidson, B; Flørenes, VA; Jørgensen, K; Rosnes, AK; Skrede, M; Slipicevic, A; Trøen, G | 1 |
| Chen, JS; Chiu, HC; Chu, CY; Dai, YS; Inoue, H; Jee, SH; Kuo, ML; Liao, YH; Lin, SJ; Shun, CT; Tjiu, JW; Tsai, TF; Yang, PC | 1 |
| Cui, J; Gao, D; Guo, K; Kang, X; Li, Y; Liu, Y; Sun, L | 1 |
| Camilli, TC; Fiori, JL; Frank, BP; French, AD; Indig, FE; Leotlela, PD; O'Connell, MP; Subaran, S; Taub, DD; Weeraratna, AT | 1 |
| Kalinovsky, T; Monterrey, JC; Niedzwiecki, A; Rath, M; Roomi, MW | 2 |
| Chung, WY; Hwang, YS; Park, HJ; Park, KK; Park, SK; Seo, JY | 1 |
| Badmaev, V; Chen, WJ; Chiou, YS; Ho, CT; Pan, MH; Wang, JM | 1 |
| Kalinovsky, T; Niedzwiecki, A; Rath, M; Roomi, MW; Roomi, NW | 1 |
| Choi, CY; Choi, JH; Choi, JM; Chung, YC; Han, EH; Hwang, YP; Jeong, HG; Seo, JK | 1 |
| Choi, JH; Hwang, YP; Jeong, HG; Kang, KW; Yun, HJ | 1 |
| Bae, YS; Chang, YC; Cho, HJ; Chung, IK; Han, SM; Jeong, YJ; Lee, KG; Park, KK; Park, YY; Yeo, JH | 1 |
| Chung, EY; Han, JH; Jeong, YJ; Jung, JY; Jung, SH; Kim, BS; Kim, JS; Lee, SH; Lee, YR; Noh, EM; Youn, HJ | 1 |
| Chang, YC; Cho, HJ; Chung, IK; Jeong, YJ; Kim, M; Lee, KG; Min, KS; Park, JH; Park, KK; Yeo, JH | 1 |
| Huang, YY; Hung, CM; Kao, ST; Lee, KH; Liu, CJ; Yeh, CC; Yeh, MH | 1 |
| Cowan, BJ; Cowan, KN; Laird, DW; Langlois, S; Shao, Q | 1 |
| Chen, YC; Chien, CC; Lin, CW; Shen, SC; Shia, LT; Yang, LY | 1 |
| Kim, JY; Lee, TJ; Noh, HJ; Song, IH; Sung, EG | 1 |
| Hwang, YP; Jeong, HG | 1 |
| Chew, EH; Chui, WK; Ling, H; Tan, SH; Yang, H | 1 |
| Tokiwa, T; Yamazaki, T | 1 |
| Du, B; Han, H; Lian, X; Liu, J; Liu, M; Pan, X; Qian, M; Zhao, Q | 1 |
| Han, JH; Hur, H; Hwang, JK; Jung, JY; Jung, SH; Kim, BS; Kim, JM; Kim, JS; Lee, SH; Lee, YR; Noh, EM; Oh, HJ; Park, BH; Park, CS; Park, JW; Youn, HJ | 1 |
| Choi, JH; Chung, YC; Han, EH; Hwang, YP; Jeong, HG; Kim, HG; Yun, HJ | 1 |
| Baker, SJ; Ellison, DW; Endersby, R; Hay, N; Zhu, X | 1 |
| Huang, JA; Jiang, HX; Liu, SQ; Qin, MB; Tang, GD; Zhong, YY | 1 |
| Lee, J; Lim, KT | 1 |
| Jang, SW; Kang, H; Kim, Y; Ko, J | 1 |
| Chen, YL; Chiang, YL; Lu, SH; Sun, FM; Weng, CJ; Yen, GC | 1 |
| Katiyar, SK; Singh, T | 1 |
| Bak, Y; Chung, IM; Kim, JH; Kim, MS; Yoon, DY | 1 |
| Chung, WY; Hwang, YS; Park, KK | 1 |
| Jung, JS; Jung, K; Kim, DH; Kim, HS | 1 |
| Kim, KM; Kim, KS; Lee, JH; Lee, YC; Moon, HI; Yu, HY | 1 |
| Liao, YF; Rao, YK; Tzeng, YM | 1 |
| Kim, Y; Kim, YH; Lee, SJ; Park, SY | 1 |
| Chang, Y; Chen, JY; Chou, SP; Fang, CY; Hsu, HY; Huang, SY; Takada, K; Tsai, CH; Wu, CC | 1 |
| Azorsa, DO; Byron, SA; Hostetter, G; Kim, S; Little, TH; Min, E; Tapia, C; Thal, TS; Watanabe, AT | 1 |
| Lazo, PA; Vázquez-Cedeira, M | 1 |
| Cheng, YF; Lee, YS; Shi, MD; Shih, YW; Tsai, LY | 1 |
| Kim, JH; Kim, Y; Lee, SJ; Lee, YJ; Park, SY | 1 |
| Chen, YL; Hsu, CL; Sun, FM; Tsai, CM; Weng, CJ; Yen, GC | 1 |
| Chung, EY; Hur, H; Jung, SH; Kim, JS; Lee, YR; Noh, EM; Youn, HJ | 1 |
| Braeuning, A; Münzel, PA; Schwarz, M | 1 |
| Chao, CY; Chen, HW; Li, CC; Lii, CK; Lin, LL; Liu, KL; Lu, CY | 1 |
| Chung, EY; Hwang, BM; Hwang, JK; Jung, SH; Kim, JM; Kim, JS; Kim, MS; Kwon, KB; Lee, SJ; Lee, YR; Noh, EM; You, YO; Youn, HJ | 1 |
| Joo, YE; Jung, YD; Khoi, PN; Lang, SA; Lee, YH; Park, JS; Stoeltzing, O | 1 |
| Han, J; Jung, SP; Kim, JH; Kim, JS; Kim, S; Lee, JE; Nam, SJ; Oh, SJ | 1 |
| Brown, EM; Chattopadhyay, N; Tfelt-Hansen, J | 1 |
| Chen, SM; Huang, MZ; Li, H; Pang, ZJ; Xing, FQ; Zhang, XQ | 1 |
| Hah, N; Lee, ST | 1 |
| Gabrielson, E; Kho, YH; Kim, YH; Kwon, TK; Lee, HJ; Lee, IK; Lee, SH; Park, JW; Woo, JH | 1 |
| Chen, SL; Chen, SM; Li, H; Luo, R; Pang, ZJ; Xing, FQ; Zhang, XQ; Zhao, XS | 1 |
| Sato, K; Shimizu, T; Suzuki, T; Tachibana, K; Takeda, K | 1 |
| Huang, Q; Ong, CN; Shen, HM | 1 |
| Ito, A; Miyata, Y; Sato, T; Yano, M | 1 |
| Cao, X; Kambe, F; Mitsuyama, H; Murakami, R; Nagaya, T; Saito, K; Seo, H; Wakabayashi, K; Yoshida, J | 1 |
| Frilling, A; Häussinger, D; Horbach, A; Kubitz, R; Schmitt, M | 1 |
| Gho, YS; Hahm, ER; Kim, KW; Park, C; Park, S; Yang, CH | 1 |
| Cardoso, F; Gonze, I; Haibe-Kains, B; Hennuy, B; Lacroix, M; Laes, JF; Lallemand, F; Leclercq, G; Piccart, M; Sotiriou, C | 1 |
| Bakin, AV; Cowell, JK; Li, X; Ranalli, TA; Sossey-Alaoui, K | 1 |
| Nanus, DM; Shen, R; Sumitomo, M | 1 |
| Hirakawa, T; Miyamoto, S; Nakano, H; Nakashima, M; Sonoda, K; Watanabe, T; Yagi, H; Yotsumoto, F | 1 |
| Toker, A; Yiu, GK | 1 |
| Chen, YC; Chien, LL; Lee, HM; Lin, CW; Shen, SC | 1 |
| Ivanov, V; Kalinovsky, T; Niedzwiecki, A; Rath, M; Roomi, MW | 1 |
| Kim, J; Kim, SH | 1 |
| Chung, AS; Kim, A; Oh, JH; Park, JM | 1 |
| Foda, H; Hymowitz, M; Montana, S; Rollo, EE; Schmidt, CE; Zucker, S | 1 |
| Huang, Q; Li, Z; Ong, CN; Shen, HM; Wu, X; Zhang, S | 1 |
| Abdel-Fattah, R; Agi, CU; Amos, S; Fang, Z; Hussaini, IM; Laws, ER; Leung, GK; Lopes, MB; Redpath, GT; Trotter, C; Xiao, A; Zhao, Y | 1 |
| Choi, HG; Kim, JA; Kwak, MK; Lee, ES; Lee, YS; Park, BC; Thapa, D; Yong, CS | 1 |
| Ferra, A; Forrow, S; Gilchrist, DS; Graham, GJ; Hunter, KD; King, V; Nibbs, RJ | 1 |
| Han, SJ; Hyun, JW; Kim, DH; Kim, HS; Kim, SY | 1 |
| Amos, S; Carpenter, JE; diPierro, CG; Hussaini, IM; Kohutek, ZA; Mut, M; Redpath, GT; Shaffrey, ME; Wang, J; Xiao, A; Zhao, Y | 1 |
| Chau, CF; Chen, DH; Chen, KD; Weng, CJ; Yen, GC | 1 |
| Chau, CF; Hsieh, YS; Weng, CJ; Yang, SF; Yen, GC | 1 |
| Jeong, YJ; Kim, CH; Kim, M; Lee, IS; Lee, SO | 1 |
| Anda, T; Kaminogo, M; Kitange, G; Nagata, I; Shabani, HK; Shibata, S; Tsunoda, K | 1 |
| Bongarzone, I; Canevari, S; Fabbi, M; Ferrini, S; Mezzanzanica, D; Orengo, AM; Piazza, T; Puppo, A; Rossello, A; Rosso, O | 1 |
| Clark, OH; Duh, QY; Herfarth, C; Hoelting, T | 2 |
| Griffin, T; Hohberger, L; Ondrey, F; Wuertz, BR; Xie, H | 1 |
| Choi, JH; Hwang, SJ; Jeong, HG; Lee, KJ | 1 |
| Boyd, D; Clayman, G; Juarez, J; Nakajima, M; Nicolson, GL; Saya, H; Tanabe, KK | 1 |
| Hamada, J; Hosokawa, M; Imamura, M; Kobayashi, M; Li, YQ; Okada, F; Shinobu, N; Takeichi, N | 1 |
| Keogh, JP; Slomiany, A; Slomiany, BL; Vossough, S; Zirvi, KA | 1 |
| Cecchi, C; Mapelli, E; Sanfilippo, O; Supino, R | 1 |
| Bueno, J; Maiti, SN; Palao-Marco, FL; Pulyaeva, H; Thompson, EW; Tirgari, RH; Yu, M | 1 |
| Chen, ZH; Gopalakrishna, R; Gundimeda, U | 1 |
| Banfi, P; Gambetta, RA; Mapelli, E; Sala, E; Sensi, M; Supino, R; Zunino, F | 1 |
| Bucana, CD; Fidler, IJ; Xie, B | 1 |
| Clark, OH; Duh, QY; Hoelting, T; Siperstein, AE; Tezelman, S | 1 |
| Hayakawa, T; Inoue, T; Kishi, J; Koita, H; Komada, N; Koono, M; Nabeshima, K | 1 |
| Bowden, GT; Chu, YW; Hendrix, MJ; Kittelson, J; Meade-Tollin, L; Powell, MB; Tsang, TC | 1 |
| Fuchimoto, S; Iwagaki, H; Kimura, T; Nonaka, Y; Orita, K | 1 |
| Sato, H; Seiki, M | 1 |
| Dittrich, C; Grill, S; Harant, H; Huber, H; Hulla, W; Krupitza, G; Szekeres, T | 1 |
| Flug, M; Köpf-Maier, P | 1 |
| de Takats, PG; Kerr, DJ; Martin, A; Reynolds, JL; Wakelam, MJ | 1 |
| Janik, P; Kowalczyk, D; Maternicka, K; Miłoszewska, J; Szaniawska, B | 1 |
| Driessens, MH; Roos, E; Soede, RD; van Hulten, PE; van Rijthoven, EA | 1 |
| Cai, Y; Honn, KV; Lundy, SK; Porter, AT; Szekeres, K; Timar, J; Trikha, M | 1 |
| Honn, KV; Trikha, M | 1 |
| DeLeon-Fernandez, M; Dutcher, JP; Etkind, P; Oleksowicz, L | 1 |
| Fink-Puches, R; Helige, C; Hofmann-Wellenhof, R; Smolle, J; Tritthart, HA; Zellnig, G | 1 |
| Derocq, D; Garcia, M; Joubert, D; Platet, N; Prévostel, C; Rochefort, H | 1 |
| Aderem, AA; Hanson, V; Holland, JF; Ito, T; Ohnuma, T; Schwartz, GK; Tamaya, T; Yokoyama, Y | 1 |
| Boyd, D; Goepfert, H; Simon, C | 1 |
| Aasen, AO; Bjørnland, K; Brünner, N; Fodstad, O; Johansen, HT; Pedersen, KB; Ree, AH | 1 |
| Linder, S; Ljungdahl, S; Shoshan, MC; Swedenborg, J; Zhou, JN | 1 |
| Aggarwal, BB; Chintala, SK; Giri, DK; Gokaslan, ZL; Kyritsis, AP; Majumder, S; Rao, JS; Sawaya, R | 1 |
| Gawrychowski, K; Janik, P; Szaniawska, B | 1 |
| Alameda, F; Batlle, E; de Herreros, AG; del Mont Llosas, M; Díaz, V; Domínguez, D; Loukili, N; Paciucci, R; Verdú, J | 1 |
| Dickson, RB; Johnson, MD; Lippman, ME; Torri, JA | 1 |
| Arnott, C; Balkwill, F; Burke, F; East, N; Holdsworth, H; Kollias, G; Moore, RJ; Owens, DM; Pasparakis, M; Rollins, B; Stamp, G; Turner, L | 1 |
| French, DL; Hahn-Dantona, E; Nagase, H; Quigley, JP; Ramos-DeSimone, N; Sipley, J | 1 |
| Inoue, T; Koono, M; Nabeshima, K; Shimao, Y | 1 |
| Aggarwal, BB; Chintala, SK; Gokslan, Z; Kyritsis, AP; Mohan, PM; Mohanam, S; Rao, JS; Sawaya, R; Steck, P; Uhm, JH; Yung, WK | 1 |
| Hamaguchi, M; Kikkawa, F; Koike, T; Liu, E; Machida, K; Matsuda, S; Seiki, M; Sein, TT; Thant, AA | 1 |
| Hudson, MA; McReynold, LM | 1 |
| Ahn, DH; Baek, SH; Chae, HS; Erickson, RH; Han, SY; Kim, HR; Kim, YS; Lee, MS; Sleisenger, MH | 1 |
| Choe, TB; Hong, SI; Hur, JH; Lee, SH; Park, IC; Park, MJ; Rhee, CH; Yi, DH | 1 |
| Hirashima, Y; Kobayashi, H; Suzuki, M; Tanaka, Y; Terao, T | 1 |
| Boyd, DD; Wang, H; Yan, C | 1 |
| Noti, JD | 1 |
| Alpaugh, ML; Barsky, SH; Deato, M; Dishakjian, L; Lee, MC; Nguyen, M | 1 |
| Foidart, JM; Frankenne, F; Grams, F; Krell, HW; Maquoi, E; Noël, A | 1 |
| Appert, HE; Bartsch, JE; Howard, JM; Iwamura, T; Staren, ED; Yang, X | 1 |
| Dinh, DH; Foster, DC; Gujrati, M; Kisiel, W; Konduri, SD; Kouraklis, G; Olivero, WC; Osman, FA; Rao, CN; Rao, JS; Srinivas, H; Tasiou, A; Yanamandra, N | 1 |
| Bogart, DF; Li, P; Lupu, R; Mehmi, I; Tsai, MS | 1 |
| Alvarez, E; Aulicino, P; Ernst, G; García, M; Hajos, SE; Lopes, EC; Vanzulli, S | 1 |
| Caamano, J; Garcia-Palazzo, I; Harris, CC; Iizasa, T; Klein-Szanto, AJ; Metcalf, R; Momiki, S; Welsh, J | 1 |
| Bhargava, M; Donovan, MA; Goldberg, ID; Kacinski, BM; Liu, D; Reiss, M; Rosen, EM; Setter, E | 1 |
| Ahn, CH; Bonfil, DR; Fridman, R; Lacal, JC; Reich, R | 1 |
| Collier, IE; Frisch, SM; Genrich, LT; Goldberg, GI; Martin, G; Reich, R | 1 |
| Bonfil, RD; Fridman, R; Harris, CC; Klein-Szanto, A; Momiki, S; Reddel, R; Reich, R | 1 |
| Frisch, SM; Ruley, HE | 1 |
| Biempica, L; Nakagawa, S; Takahashi, S; Zeydel, M | 1 |
| Friedman, EA | 2 |
3 review(s) available for tetradecanoylphorbol acetate and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Non-melanoma skin cancer in mouse and man.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Disease Progression; Genes, p53; Genes, ras; Humans; Melanoma; Mice; Mutation; Neoplasm Invasiveness; Neoplastic Stem Cells; Papilloma; Risk Assessment; Skin; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 2013 |
Involvement of neutral endopeptidase in neoplastic progression.
Topics: Apoptosis; Cell Movement; CSK Tyrosine-Protein Kinase; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; Hyaluronan Receptors; Male; Neoplasm Invasiveness; Neprilysin; Neurofibromin 2; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; src-Family Kinases; Tetradecanoylphorbol Acetate; Tumor Suppressor Proteins | 2005 |
Role of 12-lipoxygenase and protein kinase C in modulating the activation state of the integrin alpha IIb beta 3 on human tumor cells.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonate 12-Lipoxygenase; Cell Adhesion; Cell Movement; Disease Progression; Enzyme Activation; Extracellular Matrix; Humans; Models, Biological; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
178 other study(ies) available for tetradecanoylphorbol acetate and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Inhibition of cell invasion and migration by targeting matrix metalloproteinase-9 expression via sirtuin 6 silencing in human breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; NF-kappa B; Sirtuins; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2022 |
Inhibition of TPA‑induced metastatic potential by morin hydrate in MCF‑7 human breast cancer cells via the Akt/GSK‑3β/c‑Fos signaling pathway.
Topics: Breast Neoplasms; Cell Movement; Cell Survival; Flavonoids; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3 beta; Humans; MCF-7 Cells; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fos; Signal Transduction; Tetradecanoylphorbol Acetate | 2020 |
Dioscorea nipponica Makino suppresses TPA-induced migration and invasion through inhibition of matrix metalloproteinase-9 in human cervical cancer cells.
Topics: Cell Line, Tumor; Cell Movement; Dioscorea; Female; HeLa Cells; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Phosphorylation; Plant Extracts; Tetradecanoylphorbol Acetate; Uterine Cervical Neoplasms | 2020 |
Bruton's agammaglobulinemia tyrosine kinase (Btk) regulates TPA‑induced breast cancer cell invasion via PLCγ2/PKCβ/NF‑κB/AP‑1‑dependent matrix metalloproteinase‑9 activation.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Breast Neoplasms; Cell Movement; Female; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; NF-kappa B; Phospholipase C gamma; Piperidines; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2021 |
Cell Signaling Pathway in 12-O-Tetradecanoylphorbol-13-acetate-Induced LCN2 Gene Transcription in Esophageal Squamous Cell Carcinoma.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Gene Expression Regulation, Neoplastic; Humans; Lipocalin-2; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Proteins; Promoter Regions, Genetic; Protein Kinase C-alpha; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic | 2017 |
Novel dual-targeting anti-proliferative dihydrotriazine-chalcone derivatives display suppression of cancer cell invasion and inflammation by inhibiting the NF-κB signaling pathway.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chalcone; Cyclooxygenase 2; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Humans; Inflammation; Inflammation Mediators; Lipopolysaccharides; Matrix Metalloproteinase 9; Mice; Monocytes; Neoplasm Invasiveness; NF-kappa B; Nitric Oxide Synthase Type II; RAW 264.7 Cells; Signal Transduction; Tetradecanoylphorbol Acetate; Triazines | 2018 |
Porphyromonas gingivalis lipopolysaccharide-induced macrophages modulate proliferation and invasion of head and neck cancer cell lines.
Topics: Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Culture Media, Conditioned; Cytokines; Head and Neck Neoplasms; Humans; Lipopolysaccharides; Macrophages; Neoplasm Invasiveness; Nitric Oxide; Porphyromonas gingivalis; Tetradecanoylphorbol Acetate | 2018 |
Orientin inhibits invasion by suppressing MMP-9 and IL-8 expression via the PKCα/ ERK/AP-1/STAT3-mediated signaling pathways in TPA-treated MCF-7 breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Glucosides; Humans; Interleukin-8; Luteolin; Matrix Metalloproteinase 9; MCF-7 Cells; Mitogen-Activated Protein Kinase 6; Neoplasm Invasiveness; NF-kappa B; Protein Kinase C-alpha; Signal Transduction; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Tissue Array Analysis; Transcription Factor AP-1 | 2018 |
Bone marrow-derived epithelial cells and hair follicle stem cells contribute to development of chronic cutaneous neoplasms.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Bone Morphogenetic Protein 5; Cell Movement; Cell Plasticity; Cell Transformation, Neoplastic; Coculture Techniques; Epithelial Cells; Female; Hair Follicle; HMGB1 Protein; Keratinocytes; Keratins; Male; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Papilloma; Skin Neoplasms; Stem Cells; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2018 |
Suppression of PMA-induced human fibrosarcoma HT-1080 invasion and metastasis by kahweol via inhibiting Akt/JNK1/2/p38 MAPK signal pathway and NF-κB dependent transcriptional activities.
Topics: Cell Line, Tumor; Coffee; Diterpenes; Fibrosarcoma; Humans; MAP Kinase Signaling System; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; Tetradecanoylphorbol Acetate; Transcription, Genetic | 2019 |
Praeruptorin-B Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Cell Invasion by Targeting AKT/NF-κB via Matrix Metalloproteinase-2/-9 Expression in Human Cervical Cancer Cells.
Topics: Antineoplastic Agents, Phytogenic; Coumarins; Drugs, Chinese Herbal; Female; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; NF-kappa B; Proto-Oncogene Proteins c-akt; Signal Transduction; Tetradecanoylphorbol Acetate; Uterine Cervical Neoplasms | 2019 |
Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts.
Topics: Animals; Carcinoma, Pancreatic Ductal; cdc42 GTP-Binding Protein; Cell Movement; Cell Surface Extensions; Coculture Techniques; Cytoskeletal Proteins; Extracellular Matrix; Fibroblasts; Humans; Mice; Neoplasm Invasiveness; Neoplasm Transplantation; Pancreatic Neoplasms; Pancreatic Stellate Cells; Phosphoproteins; Protein Transport; Tetradecanoylphorbol Acetate | 2014 |
Induction of heme oxygenase-1 and inhibition of TPA-induced matrix metalloproteinase-9 expression by andrographolide in MCF-7 human breast cancer cells.
Topics: Bilirubin; Breast Neoplasms; Carbon Monoxide; Cell Line, Tumor; Cell Movement; Diterpenes; Enzyme Induction; Female; Heme Oxygenase-1; Humans; Iron; MAP Kinase Signaling System; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transcriptional Activation | 2013 |
Selaginella tamariscina extract suppresses TPA-induced invasion and metastasis through inhibition of MMP-9 in human nasopharyngeal carcinoma HONE-1 cells.
Topics: Carcinoma; Cell Line, Tumor; Cell Movement; Cell Survival; Humans; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mitogen-Activated Protein Kinase Kinases; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Plant Extracts; RNA, Messenger; Selaginellaceae; Signal Transduction; Tetradecanoylphorbol Acetate; Wound Healing | 2013 |
[Sphingosine kinase 1 enhances the proliferation and invasion of human colon cancer LoVo cells through up-regulating FAK pathway and the expression of ICAM-1 and VCAM-1].
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Inhibitors; Focal Adhesion Kinase 1; Humans; Intercellular Adhesion Molecule-1; Neoplasm Invasiveness; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); RNA, Messenger; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Vascular Cell Adhesion Molecule-1 | 2013 |
Sanguinarine inhibits invasiveness and the MMP-9 and COX-2 expression in TPA-induced breast cancer cells by inducing HO-1 expression.
Topics: Anti-Infective Agents; Benzophenanthridines; Breast Neoplasms; Cell Movement; Cyclooxygenase 2; Female; Gene Expression Regulation, Neoplastic; Heme Oxygenase-1; Humans; Isoquinolines; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transcription Factor AP-1; Transcription Factor RelA | 2014 |
Down-modulation of Bis reduces the invasive ability of glioma cells induced by TPA, through NF-κB mediated activation of MMP-9.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Movement; Down-Regulation; Enzyme Activation; Gene Knockdown Techniques; Glioma; Humans; I-kappa B Proteins; Matrix Metalloproteinase 9; Neoplasm Invasiveness; NF-KappaB Inhibitor alpha; Phosphorylation; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transcription Factor RelA | 2014 |
Genistein inhibits tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Genistein; Glycine max; Hep G2 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Matrix Metalloproteinase 9; Mice; Mice, Nude; Neoplasm Invasiveness; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphorylation; Phytotherapy; Plant Extracts; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2014 |
Mycoepoxydiene induces apoptosis and inhibits TPA-induced invasion in human cholangiocarcinoma cells via blocking NF-κB pathway.
Topics: Antineoplastic Agents; Apoptosis; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Bridged-Ring Compounds; Cell Line, Tumor; Cell Movement; Cell Survival; Cholangiocarcinoma; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Matrix Metalloproteinase 9; Neoplasm Invasiveness; NF-kappa B; Promoter Regions, Genetic; Pyrones; Signal Transduction; Tetradecanoylphorbol Acetate; Transcriptional Activation | 2014 |
Building bridges toward invasion: tumor promoter treatment induces a novel protein kinase C-dependent phenotype in MCF10A mammary cell acini.
Topics: Acinar Cells; Actins; Breast Neoplasms; Cadherins; Carcinogenesis; Cell Aggregation; Cell Death; Cell Line; Cell Polarity; Female; Humans; Laminin; Mammary Glands, Human; Mitosis; Neoplasm Invasiveness; Phenotype; Protein Kinase C; Tetradecanoylphorbol Acetate; Time Factors | 2014 |
Decursin prevents TPA-induced invasion through suppression of PKCα/p38/NF-κB-dependent MMP-9 expression in MCF-7 human breast carcinoma cells.
Topics: Benzopyrans; Breast Neoplasms; Butyrates; Carcinogens; Cell Proliferation; Cell Survival; Female; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; Signal Transduction; Tetradecanoylphorbol Acetate | 2014 |
Platycodin D induces apoptosis, and inhibits adhesion, migration and invasion in HepG2 hepatocellular carcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Hep G2 Cells; Humans; Inhibitor of Apoptosis Proteins; Liver Neoplasms; Medicine, Chinese Traditional; Neoplasm Invasiveness; Plant Extracts; Poly(ADP-ribose) Polymerases; Saponins; Survivin; Tetradecanoylphorbol Acetate; Triterpenes; Up-Regulation | 2014 |
Shikonin blocks migration and invasion of human breast cancer cells through inhibition of matrix metalloproteinase-9 activation.
Topics: Breast Neoplasms; Cell Movement; Female; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; MCF-7 Cells; Naphthoquinones; Neoplasm Invasiveness; Signal Transduction; Tetradecanoylphorbol Acetate | 2014 |
Furanodiene, a natural small molecule suppresses metastatic breast cancer cell migration and invasion in vitro.
Topics: Antineoplastic Agents; Biological Products; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Furans; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 2-Ring; Humans; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Metastasis; Tetradecanoylphorbol Acetate | 2014 |
Slit2 promotes tumor growth and invasion in chemically induced skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Basement Membrane; Blood Vessels; Bromodeoxyuridine; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Collagen Type IV; Humans; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Neoplasm Invasiveness; Nerve Tissue Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Burden | 2014 |
Saussurea lappa extract suppresses TPA-induced cell invasion via inhibition of NF-κB-dependent MMP-9 expression in MCF-7 breast cancer cells.
Topics: Breast Neoplasms; Cell Movement; Cell Survival; Down-Regulation; Female; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; NF-kappa B; Phosphorylation; Plant Extracts; Saussurea; Tetradecanoylphorbol Acetate; Transcriptional Activation | 2014 |
Effects of eicosapentaenoic acid and docosahexaenoic acid on prostate cancer cell migration and invasion induced by tumor-associated macrophages.
Topics: Cell Movement; Cell Survival; Coculture Techniques; Culture Media, Conditioned; Docosahexaenoic Acids; Eicosapentaenoic Acid; Humans; Macrophage Activation; Macrophages; Male; Neoplasm Invasiveness; Prostatic Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2014 |
Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway.
Topics: Cell Line, Tumor; Cells, Cultured; Desipramine; Enzyme Inhibitors; Gene Knockdown Techniques; HeLa Cells; Humans; Interleukin-6; MCF-7 Cells; Neoplasm Invasiveness; Niemann-Pick Diseases; p38 Mitogen-Activated Protein Kinases; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Sphingomyelin Phosphodiesterase; Tetradecanoylphorbol Acetate | 2014 |
Suppression of PMA-induced tumor cell invasion and migration by ginsenoside Rg1 via the inhibition of NF-κB-dependent MMP-9 expression.
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinogens; Cell Movement; Drug Antagonism; Female; Gene Expression Regulation, Neoplastic; Ginsenosides; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; NF-kappa B; Tetradecanoylphorbol Acetate | 2014 |
Resveratrol suppresses TPA-induced matrix metalloproteinase-9 expression through the inhibition of MAPK pathways in oral cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Survival; Down-Regulation; Enzyme Activation; Head and Neck Neoplasms; Humans; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mouth Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Resveratrol; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Stilbenes; Tetradecanoylphorbol Acetate; Tongue Neoplasms | 2015 |
Glaucine inhibits breast cancer cell migration and invasion by inhibiting MMP-9 gene expression through the suppression of NF-κB activation.
Topics: Aporphines; Breast Neoplasms; Cell Movement; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; NF-kappa B; Promoter Regions, Genetic; Protein Binding; Proteolysis; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic | 2015 |
Naringenin suppresses TPA-induced tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cell Movement; Flavanones; Hep G2 Cells; Humans; I-kappa B Proteins; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Mice; Neoplasm Invasiveness; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphorylation; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2015 |
Aurora kinases are essential for PKC-induced invasion and matrix metalloproteinase-9 expression in MCF-7 breast cancer cells.
Topics: Aurora Kinase A; Aurora Kinase B; Breast Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Mitogen-Activated Protein Kinase Kinases; Neoplasm Invasiveness; NF-kappa B; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate | 2015 |
Fisetin regulates TPA-induced breast cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways.
Topics: Breast Neoplasms; Cell Membrane; DNA; Enzyme Activation; Flavonoids; Flavonols; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; MCF-7 Cells; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; NF-kappa B; Protein Kinase C-alpha; Protein Transport; Reactive Oxygen Species; Tetradecanoylphorbol Acetate | 2015 |
Notch1 Activation or Loss Promotes HPV-Induced Oral Tumorigenesis.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Breast Neoplasms; Carcinogens; Carcinoma, Verrucous; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cocarcinogenesis; Disease Progression; DNA Transposable Elements; Female; Humans; Mice; Mice, Transgenic; Mouth Neoplasms; Mutagenesis, Insertional; Neoplasm Invasiveness; Oncogenes; Papilloma; Papillomaviridae; Receptor, Notch1; Skin Neoplasms; Specific Pathogen-Free Organisms; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Virus Infections; Uterine Cervical Neoplasms | 2015 |
TSG101, a tumor susceptibility gene, bidirectionally modulates cell invasion through regulating MMP-9 mRNA expression.
Topics: Cell Line, Tumor; Cell Movement; DNA-Binding Proteins; Endosomal Sorting Complexes Required for Transport; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasms; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factors | 2015 |
Suppression of TPA-induced cancer cell invasion by Peucedanum japonicum Thunb. extract through the inhibition of PKCα/NF-κB-dependent MMP-9 expression in MCF-7 cells.
Topics: Antineoplastic Agents, Phytogenic; Apiaceae; Breast; Breast Neoplasms; Carcinogens; Female; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; NF-kappa B; Protein Kinase C-alpha; Signal Transduction; Tetradecanoylphorbol Acetate | 2016 |
Rhein suppresses matrix metalloproteinase production by regulating the Rac1/ROS/MAPK/AP-1 pathway in human ovarian carcinoma cells.
Topics: Aminoquinolines; Anthraquinones; Cell Line, Tumor; Cell Movement; Female; Humans; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Matrix Metalloproteinases, Secreted; Neoplasm Invasiveness; NM23 Nucleoside Diphosphate Kinases; Ovarian Neoplasms; Phosphorylation; Pyrimidines; rac1 GTP-Binding Protein; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transcription Factor AP-1 | 2017 |
Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells.
Topics: Biphenyl Compounds; Breast Neoplasms; Carcinogens; Cell Movement; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Hydrazines; Hydroxyl Radical; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Picrates; Protein Kinase C-delta; Quercetin; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic | 2008 |
The immunoregulatory protein human B7H3 is a tumor-associated antigen that regulates tumor cell migration and invasion.
Topics: Antigens, CD; Antigens, Neoplasm; Antiviral Agents; B7 Antigens; Binding, Competitive; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Collagen; Drug Combinations; Enzyme-Linked Immunosorbent Assay; Fibronectins; Flow Cytometry; Glycosylation; Humans; Immunoprecipitation; Laminin; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Proteoglycans; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tunicamycin | 2008 |
The fatty acid binding protein 7 (FABP7) is involved in proliferation and invasion of melanoma cells.
Topics: Biomarkers, Tumor; Carcinogens; Carrier Proteins; Cell Nucleus; Cell Proliferation; Cytoplasm; Disease Progression; Enzyme Inhibitors; Fatty Acid-Binding Protein 7; Flavonoids; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Immunoenzyme Techniques; Melanoma; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Nevus, Pigmented; Oligonucleotide Array Sequence Analysis; Prognosis; RNA, Messenger; RNA, Small Interfering; Skin Neoplasms; Survival Rate; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2008 |
Tumor-associated macrophage-induced invasion and angiogenesis of human basal cell carcinoma cells by cyclooxygenase-2 induction.
Topics: Carcinoma, Basal Cell; Cell Line, Tumor; Cell Polarity; Cyclooxygenase 2; Enzyme Induction; Fibroblast Growth Factor 2; Humans; Macrophages; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neovascularization, Pathologic; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A | 2009 |
Role of PKCbeta in hepatocellular carcinoma cells migration and invasion in vitro: a potential therapeutic target.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Humans; Indoles; Liver Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Protein Kinase C; Protein Kinase C beta; RNA Interference; Tetradecanoylphorbol Acetate | 2009 |
PKC and PKA phosphorylation affect the subcellular localization of claudin-1 in melanoma cells.
Topics: Biological Transport; Cell Line, Tumor; Cell Nucleus; Claudin-1; Computer Simulation; Cyclic AMP-Dependent Protein Kinases; Cytoplasm; Enzyme Activation; Genetic Vectors; Humans; Immunohistochemistry; Matrix Metalloproteinase 2; Melanoma; Membrane Proteins; Mutagenesis, Site-Directed; Neoplasm Invasiveness; Neoplasm Metastasis; Nuclear Localization Signals; Phosphorylation; Protein Kinase C; Subcellular Fractions; Tetradecanoylphorbol Acetate; Transfection | 2009 |
Patterns of MMP-2 and MMP-9 expression in human cancer cell lines.
Topics: Cell Line, Tumor; Enzyme Induction; Female; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasms; Tetradecanoylphorbol Acetate | 2009 |
Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells.
Topics: Acetophenones; Animals; Antineoplastic Agents, Phytogenic; Benzopyrans; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Neoplasm Transplantation; NF-kappa B; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C-delta; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transplantation, Heterologous | 2009 |
Pterostilbene inhibited tumor invasion via suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Movement; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Lung Neoplasms; Matrix Metalloproteinase 9; Mice; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Neoplasm Transplantation; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Signal Transduction; Stilbenes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transplantation, Heterologous | 2009 |
Marked inhibition of growth and invasive parameters of head and neck squamous carcinoma FaDu by a nutrient mixture.
Topics: Administration, Oral; Amino Acids; Animals; Apoptosis; Ascorbic Acid; Camellia sinensis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Complementary Therapies; Food; Head and Neck Neoplasms; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Nude; Neoplasm Invasiveness; Plant Extracts; Tetradecanoylphorbol Acetate; Xenograft Model Antitumor Assays | 2009 |
Suppression of PMA-induced tumor cell invasion and metastasis by aqueous extract isolated from Prunella vulgaris via the inhibition of NF-kappaB-dependent MMP-9 expression.
Topics: Administration, Oral; Animals; Cell Movement; Cell Nucleus; Lung Neoplasms; Matrix Metalloproteinase 9; Melanoma; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; Phosphorylation; Plant Extracts; Prunella; Tetradecanoylphorbol Acetate; Translocation, Genetic; Xenograft Model Antitumor Assays | 2010 |
Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by bergamottin via the inhibition of protein kinase Cdelta/p38 mitogen-activated protein kinase and JNK/nuclear factor-kappaB-dependent matrix metalloproteinase-9 expression.
Topics: Antineoplastic Agents, Phytogenic; Carcinogens; Cell Line, Tumor; Cell Movement; Cytochrome P-450 Enzyme Inhibitors; Down-Regulation; Fibrosarcoma; Furocoumarins; Humans; I-kappa B Proteins; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; NF-kappa B; NF-KappaB Inhibitor alpha; Osmolar Concentration; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C-delta; Protein Transport; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate | 2010 |
Bee venom suppresses PMA-mediated MMP-9 gene activation via JNK/p38 and NF-kappaB-dependent mechanisms.
Topics: Antineoplastic Agents; Apitherapy; Bee Venoms; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; DNA; Female; Humans; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 9; Melitten; Neoplasm Invasiveness; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Signal Transduction; Tetradecanoylphorbol Acetate; Transcriptional Activation | 2010 |
Cordycepin inhibits TPA-induced matrix metalloproteinase-9 expression by suppressing the MAPK/AP-1 pathway in MCF-7 human breast cancer cells.
Topics: Analysis of Variance; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Deoxyadenosines; Female; Gene Expression; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; NF-kappa B; Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2010 |
Melittin suppresses PMA-induced tumor cell invasion by inhibiting NF-kappaB and AP-1-dependent MMP-9 expression.
Topics: Apamin; Cell Line, Tumor; Cell Movement; Drug Screening Assays, Antitumor; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Melitten; Neoplasm Invasiveness; NF-kappa B; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2010 |
The inhibitory effect of hesperidin on tumor cell invasiveness occurs via suppression of activator protein 1 and nuclear factor-kappaB in human hepatocellular carcinoma cells.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Hesperidin; Humans; I-kappa B Kinase; Liver Neoplasms; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; NF-kappa B; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2010 |
The tumor-suppressive function of Connexin43 in keratinocytes is mediated in part via interaction with caveolin-1.
Topics: Animals; Anti-Ulcer Agents; Blotting, Western; Carbenoxolone; Carcinogens; Carcinoma, Squamous Cell; Caveolin 1; Cell Communication; Cell Proliferation; Connexin 43; Epidermal Cells; Epidermal Growth Factor; Epidermis; Epithelial Cells; Fluorescent Antibody Technique; Gap Junctions; Green Fluorescent Proteins; Humans; Immunoprecipitation; Keratinocytes; Mesoderm; Neoplasm Invasiveness; Rats; RNA, Small Interfering; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta1 | 2010 |
12-O-tetradecanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCalpha/ERK/NF-kappaB-dependent MMP-9 expression.
Topics: Carcinogens; Cell Line, Tumor; Cell Movement; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; MAP Kinase Kinase 4; Matrix Metalloproteinase 9; Molecular Structure; Neoplasm Invasiveness; NF-kappa B; Protein Kinase C-alpha; RNA Interference; Tetradecanoylphorbol Acetate | 2010 |
Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by apigenin via the inhibition of p38 mitogen-activated protein kinase-dependent matrix metalloproteinase-9 expression.
Topics: Apigenin; Cell Movement; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Drug Evaluation, Preclinical; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2010 |
Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated kinase/act
Topics: Calcium; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Matrix Metalloproteinase 9; Metformin; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2010 |
Comparative effects of EGCG, green tea and a nutrient mixture on the patterns of MMP-2 and MMP-9 expression in cancer cell lines.
Topics: Antineoplastic Agents, Phytogenic; Ascorbic Acid; Camellia sinensis; Catechin; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Lysine; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Micronutrients; Neoplasm Invasiveness; Neoplasms; Plant Extracts; Proline; Protease Inhibitors; Tetradecanoylphorbol Acetate | 2010 |
6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation.
Topics: Antineoplastic Agents; Breast Neoplasms; Catechols; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Female; Humans; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 9; Matrix Metalloproteinases, Secreted; Neoplasm Invasiveness; NF-kappa B; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Zingiber officinale | 2010 |
Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits matrix metalloproteinase-7 expression and cell invasion of human hepatoma cells.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Line, Tumor; Coumarins; Eleutherococcus; Hep G2 Cells; Humans; Liver Neoplasms; Matrix Metalloproteinase Inhibitors; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Phosphorylation; Phytotherapy; Plant Bark; Plant Extracts; Plant Stems; Tetradecanoylphorbol Acetate | 2010 |
CADPE inhibits PMA-stimulated gastric carcinoma cell invasion and matrix metalloproteinase-9 expression by FAK/MEK/ERK-mediated AP-1 activation.
Topics: Caffeic Acids; Cell Line, Tumor; Cell Movement; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Protein-Tyrosine Kinases; Humans; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2010 |
Dihydroavenanthramide D inhibits human breast cancer cell invasion through suppression of MMP-9 expression.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Survival; Humans; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; ortho-Aminobenzoates; Signal Transduction; Tetradecanoylphorbol Acetate | 2011 |
Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by piperine via the inhibition of PKCα/ERK1/2-dependent matrix metalloproteinase-9 expression.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Benzodioxoles; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Down-Regulation; Fibrosarcoma; Gene Expression Regulation, Enzymologic; Humans; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; NF-kappa B; Phosphorylation; Piperidines; Polyunsaturated Alkamides; Protein Kinase C-alpha; Proto-Oncogene Proteins c-jun; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor AP-1; Transcription, Genetic; Transfection | 2011 |
Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model.
Topics: Animals; Astrocytes; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Glioma; Humans; Isoenzymes; Mice; Neoplasm Invasiveness; Neoplasm Transplantation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2011 |
[Effect of sphingosine kinase 1 on the apoptosis, migration and invasion of colon cancer HT-29 cells and its molecular mechanisms].
Topics: Apoptosis; Carcinogens; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; HT29 Cells; Humans; MAP Kinase Kinase 4; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Sphingosine; Tetradecanoylphorbol Acetate; Time Factors | 2011 |
Inhibitory effect of phytoglycoprotein (38 kDa) on expression of matrix metalloproteinase-9 in 12-O-tetradecanoylphorbol-13-acetate-treated HepG2cells.
Topics: Antineoplastic Agents, Phytogenic; Cell Movement; Electrophoretic Mobility Shift Assay; Glycoproteins; Hep G2 Cells; Humans; Immunoblotting; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; Reactive Oxygen Species; Signal Transduction; Styrax; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2011 |
Celastrol inhibits breast cancer cell invasion via suppression of NF-ĸB-mediated matrix metalloproteinase-9 expression.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Gene Expression Regulation, Enzymologic; Humans; I-kappa B Kinase; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Medicine, Chinese Traditional; Neoplasm Invasiveness; NF-kappa B; Pentacyclic Triterpenes; Promoter Regions, Genetic; Tetradecanoylphorbol Acetate; Triterpenes | 2011 |
A comparative study on the effectiveness of cis- and trans-form of cinnamic acid treatments for inhibiting invasive activity of human lung adenocarcinoma cells.
Topics: Antineoplastic Agents; Cell Adhesion; Cell Culture Techniques; Cell Line, Tumor; Cell Movement; Cell Survival; Chromatography, High Pressure Liquid; Cinnamates; Dose-Response Relationship, Drug; Drug Stability; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Models, Biological; Neoplasm Invasiveness; Stereoisomerism; Tetradecanoylphorbol Acetate | 2011 |
Green tea catechins reduce invasive potential of human melanoma cells by targeting COX-2, PGE2 receptors and epithelial-to-mesenchymal transition.
Topics: Catechin; Celecoxib; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Drug Screening Assays, Antitumor; Epithelial-Mesenchymal Transition; Humans; Melanoma; Neoplasm Invasiveness; NF-kappa B; Pyrazoles; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Sulfonamides; Tea; Tetradecanoylphorbol Acetate; Transcription Factor RelA | 2011 |
The cadin-2-en-1β-ol-1β-D-glucuronopyranoside suppresses TPA-mediated matrix metalloproteinase-9 expression through the ERK signaling pathway in MCF-7 human breast adenocarcinoma cells.
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Catharanthus; Cell Line, Tumor; Dose-Response Relationship, Drug; Female; Glucosides; Humans; Matrix Metalloproteinase 9; Neoplasm Invasiveness; NF-kappa B; Phosphorylation; Sesquiterpenes; Signal Transduction; Tetradecanoylphorbol Acetate | 2012 |
Kalopanaxsaponin A inhibits the invasion of human oral squamous cell carcinoma by reducing metalloproteinase-9 mRNA stability and protein trafficking.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Female; Humans; Matrix Metalloproteinase 9; Mice; Mice, Nude; Mouth Neoplasms; Neoplasm Invasiveness; Oleanolic Acid; Protein Transport; RNA, Messenger; Saponins; Tetradecanoylphorbol Acetate; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |
Selective inhibition of MMP-9 gene expression by mangiferin in PMA-stimulated human astroglioma cells: involvement of PI3K/Akt and MAPK signaling pathways.
Topics: Antineoplastic Agents, Phytogenic; Astrocytoma; Binding Sites; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation, Enzymologic; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; NF-kappa B; Phosphatidylinositol 3-Kinase; Phosphorylation; Promoter Regions, Genetic; Protease Inhibitors; Proto-Oncogene Proteins c-akt; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transfection; Xanthones | 2012 |
JNP3, a new compound, suppresses PMA-induced tumor cell invasion via NF-κB down regulation in MCF-7 breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Down-Regulation; Female; Gene Expression; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Kinase 4; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; NF-kappa B; Phosphorylation; Tetradecanoylphorbol Acetate; Triterpenes | 2012 |
Aqueous extract of Anisomeles indica and its purified compound exerts anti-metastatic activity through inhibition of NF-κB/AP-1-dependent MMP-9 activation in human breast cancer MCF-7 cells.
Topics: Base Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Movement; DNA Primers; Female; Humans; Lamiaceae; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; Plant Extracts; Reverse Transcriptase Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Water | 2012 |
Frondoside A has an anti-invasive effect by inhibiting TPA-induced MMP-9 activation via NF-κB and AP-1 signaling in human breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Female; Glycosides; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Triterpenes | 2012 |
The synergistic effect of chemical carcinogens enhances Epstein-Barr virus reactivation and tumor progression of nasopharyngeal carcinoma cells.
Topics: Animals; Butyrates; Carcinogens; Carcinoma; Cell Line, Tumor; Cell Transformation, Viral; Disease Progression; Drug Synergism; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genome, Human; Genomic Instability; Herpesvirus 4, Human; Humans; Methylnitronitrosoguanidine; Mice; Mice, SCID; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Invasiveness; Tetradecanoylphorbol Acetate; Virus Activation | 2012 |
Negative regulation of NF-κB by the ING4 tumor suppressor in breast cancer.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Disease Progression; Disease-Free Survival; Down-Regulation; Homeodomain Proteins; Humans; Neoplasm Invasiveness; Phosphorylation; Tetradecanoylphorbol Acetate; Transcription Factor RelA; Transcription, Genetic; Tumor Suppressor Proteins | 2012 |
Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2.
Topics: Animals; Binding Sites; Cell Line, Tumor; Cyclooxygenase 2; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Intracellular Signaling Peptides and Proteins; Ionomycin; Isoenzymes; Mice; Models, Biological; Muscle Proteins; Neoplasm Invasiveness; Neoplasms; NFATC Transcription Factors; Phosphorylation; Phosphoserine; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Response Elements; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 2012 |
Suppression of 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 breast adenocarcinoma cells invasion/migration by α-tomatine through activating PKCα/ERK/NF-κB-dependent MMP-2/MMP-9 expressions.
Topics: Actin Cytoskeleton; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Adhesion; Cell Movement; Cell Shape; Cell Survival; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; NF-kappa B; Phosphorylation; Protein Kinase C-alpha; Tetradecanoylphorbol Acetate; Tomatine; Transcriptional Activation | 2013 |
Surfactin suppresses TPA-induced breast cancer cell invasion through the inhibition of MMP-9 expression.
Topics: Antibiotics, Antineoplastic; Apoptosis; Blotting, Western; Breast Neoplasms; Carcinogens; Cell Movement; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Humans; Lipopeptides; Matrix Metalloproteinase 9; Neoplasm Invasiveness; NF-kappa B; Peptides, Cyclic; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Cells, Cultured; Wound Healing | 2013 |
Molecular mechanism depressing PMA-induced invasive behaviors in human lung adenocarcinoma cells by cis- and trans-cinnamic acid.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Carcinogens; Cell Line, Tumor; Cinnamates; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Models, Biological; Neoplasm Invasiveness; Neoplasm Proteins; Osmolar Concentration; Stereoisomerism; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Urokinase-Type Plasminogen Activator | 2013 |
Cis-guggulsterone inhibits the IKK/NF-κB pathway, whereas trans-guggulsterone inhibits MAPK/AP-1 in MCF‑7 breast cancer cells: guggulsterone regulates MMP‑9 expression in an isomer-specific manner.
Topics: Antineoplastic Agents, Phytogenic; Breast; Breast Neoplasms; Cell Survival; Commiphora; Female; Humans; I-kappa B Kinase; Isomerism; Matrix Metalloproteinase 9; MCF-7 Cells; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; NF-kappa B; Pregnenediones; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2013 |
Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells.
Topics: Adenocarcinoma; Androstadienes; Antineoplastic Agents; Breast Neoplasms; Carcinogens; Cell Movement; Cell Survival; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Drug Antagonism; Enzyme Activation; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Gene Silencing; Heme Oxygenase-1; Humans; Indoles; Maleimides; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; Tetradecanoylphorbol Acetate; Time Factors; Wortmannin | 2013 |
Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition of NF-κB-dependent MMP-9 expression.
Topics: Antineoplastic Agents; Benzofurans; Breast Neoplasms; Enzyme Induction; Female; Flavonoids; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; NF-kappa B; Protein Binding; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation | 2013 |
EGCG inhibits recepteur d'origine nantais expression by suppressing Egr-1 in gastric cancer cells.
Topics: Animals; Catechin; Cell Line, Tumor; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Activation; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Plant Extracts; Promoter Regions, Genetic; Receptor Protein-Tyrosine Kinases; RNA Interference; RNA, Small Interfering; Stomach Neoplasms; Tea; Tetradecanoylphorbol Acetate; Transcription, Genetic; Xenograft Model Antitumor Assays | 2013 |
Silibinin inhibits TPA-induced cell migration and MMP-9 expression in thyroid and breast cancer cells.
Topics: Breast Neoplasms; Butadienes; Cell Movement; Female; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; Nitriles; Phosphorylation; Silybin; Silymarin; Tetradecanoylphorbol Acetate; Thyroid Neoplasms | 2013 |
PKC, p42/44 MAPK and p38 MAPK regulate hepatocyte growth factor secretion from human astrocytoma cells.
Topics: Astrocytoma; Cell Division; Cell Transformation, Neoplastic; Enzyme Inhibitors; Hepatocyte Growth Factor; Humans; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2002 |
[Role of phorbol 12-myristate 13-acetate on cytokine expression in JAR trophoblast cell line].
Topics: Cell Line; Choriocarcinoma; Cytokines; Endothelial Growth Factors; Female; Humans; Intercellular Signaling Peptides and Proteins; Lymphokines; Neoplasm Invasiveness; Pregnancy; RNA, Messenger; Somatomedins; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Trophoblasts; Uterine Neoplasms; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
An absolute role of the PKC-dependent NF-kappaB activation for induction of MMP-9 in hepatocellular carcinoma cells.
Topics: Carcinoma, Hepatocellular; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Matrix Metalloproteinase 9; Neoplasm Invasiveness; NF-kappa B; Promoter Regions, Genetic; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transcriptional Activation; Tumor Cells, Cultured | 2003 |
Dykellic acid inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting nuclear factor kappa B transcriptional activity.
Topics: Enzyme Induction; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Luciferases; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Proteins; NF-kappa B; Proline; Promoter Regions, Genetic; Propionates; Protein Structure, Tertiary; Pyrones; RNA, Messenger; Tetradecanoylphorbol Acetate; Thiocarbamates; Thioctic Acid; Transcription Factor AP-1; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 2003 |
[Role of p38 pathway in PMA-induced in vitro invasion of JAR human choriocarcinoma cell line].
Topics: Cell Division; Choriocarcinoma; Female; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Pregnancy; Pyridines; Tetradecanoylphorbol Acetate; Uterine Neoplasms | 2003 |
Induction of plasminogen activator inhibitor-2 is associated with suppression of invasive activity in TPA-mediated differentiation of human prostate cancer cells.
Topics: Cell Differentiation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasm Invasiveness; Plasminogen Activator Inhibitor 2; Prostatic Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2003 |
Inhibitory effect of emodin on tumor invasion through suppression of activator protein-1 and nuclear factor-kappaB.
Topics: Antineoplastic Agents; Drug Interactions; Drugs, Chinese Herbal; Emodin; Gene Expression; Humans; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Cells, Cultured | 2004 |
Activation of protein kinase C betaII/epsilon-c-Jun NH2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polymethoxy flavonoid, nobi
Topics: Anthracenes; Antineoplastic Agents; Butadienes; Cell Line, Tumor; Collagenases; Enzyme Activation; Enzyme Precursors; Flavones; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase Kinases; Neoplasm Invasiveness; Nitriles; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; raf Kinases; ras Proteins; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1 | 2004 |
Inhibitory effects of cyclosporin A on calcium mobilization-dependent interleukin-8 expression and invasive potential of human glioblastoma U251MG cells.
Topics: Calcimycin; Calcium; Cell Division; Cell Line, Tumor; Cyclosporine; Glioblastoma; Humans; I-kappa B Kinase; Interleukin-8; Neoplasm Invasiveness; NF-kappa B; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Receptors, Interleukin-8A; Receptors, Interleukin-8B; RNA, Messenger; Tetradecanoylphorbol Acetate | 2004 |
Disruption of hepatocellular tight junctions by vascular endothelial growth factor (VEGF): a novel mechanism for tumor invasion.
Topics: Carcinoma in Situ; Carcinoma, Hepatocellular; Cell Line, Tumor; Fluorescent Antibody Technique; Humans; Liver; Liver Neoplasms; Membrane Proteins; Neoplasm Invasiveness; Occludin; Phosphoproteins; Tetradecanoylphorbol Acetate; Tight Junctions; Tissue Distribution; Vascular Endothelial Growth Factor A; Zonula Occludens-1 Protein | 2004 |
Synthetic curcumin analogs inhibit activator protein-1 transcription and tumor-induced angiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Chick Embryo; Curcumin; Down-Regulation; Humans; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasms; Neovascularization, Pathologic; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic; Umbilical Cord; Vascular Endothelial Growth Factor A | 2004 |
Gene regulation by phorbol 12-myristate 13-acetate in MCF-7 and MDA-MB-231, two breast cancer cell lines exhibiting highly different phenotypes.
Topics: Biomarkers, Tumor; Breast Neoplasms; Carcinogens; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Invasiveness; Oligonucleotide Array Sequence Analysis; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2004 |
WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression.
Topics: Actins; Adenocarcinoma; Cell Line, Tumor; Cell Movement; Down-Regulation; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Imidazoles; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Microfilament Proteins; Neoplasm Invasiveness; Neuroblastoma; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Time Factors; Wiskott-Aldrich Syndrome Protein Family | 2005 |
Invasive potency related to RCAS1 expression in uterine cervical cancer.
Topics: Adult; Aged; Antigens, Neoplasm; Carcinogens; Cell Line, Tumor; Female; Fibroblasts; Humans; Immunohistochemistry; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Precancerous Conditions; Retrospective Studies; Stromal Cells; Survival Rate; Tetradecanoylphorbol Acetate; Uterine Cervical Neoplasms | 2005 |
NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2.
Topics: Breast Neoplasms; Cell Line, Tumor; Collagen; Cyclooxygenase 2; Cyclosporine; Dinoprostone; Drug Combinations; Humans; Ionomycin; Ionophores; Laminin; Neoplasm Invasiveness; Neoplasm Metastasis; NFATC Transcription Factors; Proteoglycans; RNA, Small Interfering; Tetradecanoylphorbol Acetate | 2006 |
Lipopolysaccharide plus 12-o-tetradecanoylphorbol 13-acetate induction of migration and invasion of glioma cells in vitro and in vivo: Differential inhibitory effects of flavonoids.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Carcinogens; Cell Movement; Cell Transformation, Neoplastic; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Flavanones; Flavonoids; Glioma; Humans; Kaempferols; Lipopolysaccharides; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Nitric Oxide; Nitric Oxide Synthase; Rats; Tetradecanoylphorbol Acetate | 2006 |
Modulation of human renal cell carcinoma 786-0 MMP-2 and MMP-9 activity by inhibitors and inducers in vitro.
Topics: Antineoplastic Agents; Carcinogens; Carcinoma; Cell Line, Tumor; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Interleukin-1; Kidney Neoplasms; Lipopolysaccharides; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2006 |
Reduction of invasion in human fibrosarcoma cells by ribosomal protein S3 in conjunction with Nm23-H1 and ERK.
Topics: Breast Neoplasms; Cell Line, Tumor; Fibrosarcoma; Humans; In Vitro Techniques; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Mutagenesis, Site-Directed; Neoplasm Invasiveness; NM23 Nucleoside Diphosphate Kinases; Nucleoside-Diphosphate Kinase; Recombinant Fusion Proteins; Ribosomal Proteins; Sequence Deletion; Tetradecanoylphorbol Acetate; Transfection; Two-Hybrid System Techniques | 2006 |
Methylseleninic acid inhibits PMA-stimulated pro-MMP-2 activation mediated by MT1-MMP expression and further tumor invasion through suppression of NF-kappaB activation.
Topics: Carcinogens; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Enzyme Activation; Enzyme Precursors; Fibrosarcoma; Humans; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Neoplasm Invasiveness; NF-kappa B; Organoselenium Compounds; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-2; Tumor Cells, Cultured | 2007 |
Neutrophil activator of matrix metalloproteinase-2 (NAM).
Topics: Adult; Amides; Calcimycin; Cathepsin G; Cathepsins; Cells, Cultured; Culture Media, Conditioned; Endothelium, Vascular; Enzyme Activation; Enzyme Precursors; Humans; Inflammation; Ionomycin; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Neoplasm Metastasis; Neutrophils; Oligopeptides; Pancreatic Elastase; Phenylalanine; Protease Inhibitors; Proteins; RNA, Messenger; Serine Endopeptidases; Substrate Specificity; Tetradecanoylphorbol Acetate; Thiophenes; Tissue Inhibitor of Metalloproteinase-2; Umbilical Veins | 2006 |
Methyl-3-indolylacetate inhibits cancer cell invasion by targeting the MEK1/2-ERK1/2 signaling pathway.
Topics: Cell Line, Tumor; HeLa Cells; Humans; Indoleacetic Acids; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinase 2; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neoplasms; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic; Transfection | 2006 |
Matrix metalloproteinase-9 is differentially expressed in nonfunctioning invasive and noninvasive pituitary adenomas and increases invasion in human pituitary adenoma cell line.
Topics: Adenoma; Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Pituitary Neoplasms; Protein Kinase C; Pyrones; RNA, Small Interfering; Tetradecanoylphorbol Acetate | 2007 |
1-furan-2-yl-3-pyridin-2-yl-propenone inhibits the invasion and migration of HT1080 human fibrosarcoma cells through the inhibition of proMMP-2 activation and down regulation of MMP-9 and MT1-MMP.
Topics: Blotting, Western; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Precursors; Enzyme-Linked Immunosorbent Assay; Furans; Gelatinases; Humans; Matrix Metalloproteinase 14; Matrix Metalloproteinase 9; Metalloendopeptidases; Neoplasm Invasiveness; Propane; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1; Wounds and Injuries | 2007 |
The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors.
Topics: Animals; Chemokine Receptor D6; Disease Susceptibility; Disease-Free Survival; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Keratinocytes; Mice; Mice, Transgenic; Neoplasm Invasiveness; Papilloma; Receptors, CCR10; Receptors, Chemokine; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2007 |
Repression of matrix metalloproteinase gene expression by ginsenoside Rh2 in human astroglioma cells.
Topics: Astrocytoma; Binding Sites; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Survival; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Gene Expression Regulation, Enzymologic; Ginsenosides; Humans; Matrix Metalloproteinase 1; Matrix Metalloproteinase 14; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Molecular Structure; Neoplasm Invasiveness; NF-kappa B; Phosphorylation; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2007 |
Protein kinase C-alpha-mediated regulation of low-density lipoprotein receptor related protein and urokinase increases astrocytoma invasion.
Topics: Animals; Astrocytoma; Cell Line, Tumor; Cell Movement; Humans; Immunoprecipitation; Low Density Lipoprotein Receptor-Related Protein-1; Male; Mice; Mice, SCID; Neoplasm Invasiveness; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C-alpha; Tetradecanoylphorbol Acetate; Urokinase-Type Plasminogen Activator | 2007 |
The anti-invasive effect of lucidenic acids isolated from a new Ganoderma lucidum strain.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cholic Acids; Chromatography, High Pressure Liquid; Ganoderma; Humans; Liver Neoplasms; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Terpenes; Tetradecanoylphorbol Acetate; Triterpenes | 2007 |
Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-kappaB and AP-1.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Liver Neoplasms; MAP Kinase Signaling System; Neoplasm Invasiveness; NF-kappa B; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Triterpenes | 2008 |
Suppression of PMA-induced tumor cell invasion by capillarisin via the inhibition of NF-kappaB-dependent MMP-9 expression.
Topics: Cell Line, Tumor; Chromones; Collagen; Drug Combinations; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; Laminin; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Neoplasms; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Proteoglycans; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation | 2008 |
Expression of the constitutively activated RelA/NF-kappaB in human astrocytic tumors and the in vitro implication in the regulation of urokinase-type plasminogen activator, migration, and invasion.
Topics: Astrocytoma; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Nucleus; Culture Media, Conditioned; Curcumin; Enzyme Induction; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Neoplasm Invasiveness; Neoplasm Proteins; NF-kappa B; Oligonucleotides, Antisense; Retrospective Studies; RNA, Messenger; RNA, Neoplasm; Single-Blind Method; Tetradecanoylphorbol Acetate; Transcription Factor RelA; Urokinase-Type Plasminogen Activator | 2005 |
The ALCAM shedding by the metalloprotease ADAM17/TACE is involved in motility of ovarian carcinoma cells.
Topics: ADAM Proteins; ADAM17 Protein; Antigens, CD; Ascitic Fluid; Carcinogens; Cell Adhesion; Cell Adhesion Molecules, Neuronal; Cell Line, Tumor; Cell Movement; Culture Media, Conditioned; Enzyme Activation; Enzyme Inhibitors; Female; Fetal Proteins; Humans; Neoplasm Invasiveness; Ovarian Neoplasms; RNA, Small Interfering; Solubility; Tetradecanoylphorbol Acetate; Vanadates | 2007 |
Invasion of metastatic human follicular thyroid cancer is inhibited via antagonism of protein kinase C.
Topics: Benzophenanthridines; Cell Line, Tumor; Enzyme Inhibitors; Humans; Naphthalenes; Neoplasm Invasiveness; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Thyrotropin | 1997 |
TNF-alpha drives matrix metalloproteinase-9 in squamous oral carcinogenesis.
Topics: Cell Line, Tumor; Disease Progression; Enzyme Activation; Humans; Matrix Metalloproteinase 9; Mouth Neoplasms; Neoplasm Invasiveness; Neoplasms, Squamous Cell; Precancerous Conditions; RNA, Messenger; Saliva; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Up-Regulation | 2008 |
Saponins derived from the roots of Platycodon grandiflorum inhibit HT-1080 cell invasion and MMPs activities: regulation of NF-kappaB activation via ROS signal pathway.
Topics: Antineoplastic Agents, Phytogenic; Cell Movement; Enzyme Inhibitors; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; NF-kappa B; Plant Extracts; Plant Roots; Platycodon; Reactive Oxygen Species; Signal Transduction; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1 | 2008 |
Role and regulation of expression of 92-kDa type-IV collagenase (MMP-9) in 2 invasive squamous-cell-carcinoma cell lines of the oral cavity.
Topics: Amino Acid Sequence; Base Sequence; Carcinoma, Squamous Cell; Collagenases; Enzyme Induction; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; Molecular Sequence Data; Molecular Weight; Mouth Neoplasms; Naphthalenes; Neoplasm Invasiveness; Neoplasm Proteins; Polycyclic Compounds; Protein Kinase C; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-2; Tumor Cells, Cultured | 1993 |
A possible role of 92 kDa type IV collagenase in the extramedullary tumor formation in leukemia.
Topics: Collagenases; Glycoproteins; Humans; Interferon-alpha; Interleukin-1; Interleukin-6; Leukemia; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Metastasis; Sarcoma; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinases; Transforming Growth Factor beta; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1995 |
Pharmacological alterations of cellular transglutaminase activity and invasiveness in human colorectal carcinoma cells.
Topics: Adenocarcinoma; Colonic Neoplasms; Colorectal Neoplasms; Humans; Neoplasm Invasiveness; Retinoids; Tetradecanoylphorbol Acetate; Transglutaminases; Tretinoin; Tumor Cells, Cultured | 1993 |
Modification of invasion and differentiation in human melanoma cell clones.
Topics: Cell Survival; Cell Transformation, Neoplastic; Chemotaxis; Doxorubicin; Humans; Melanoma; Neoplasm Invasiveness; Plasminogen Activators; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1994 |
Differential regulation of matrix metalloproteinase-2 activation in human breast cancer cell lines.
Topics: Breast Neoplasms; Cell Line; Concanavalin A; Enzyme Activation; Gelatinases; Humans; Matrix Metalloproteinase 2; Metalloendopeptidases; Neoplasm Invasiveness; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vimentin | 1994 |
Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells.
Topics: Animals; Carcinogens; Catechols; Cell Membrane; Chelating Agents; Cytosol; Hydroquinones; Lung Neoplasms; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Neoplasm Metastasis; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Inbred Lew; Smoke; Smoking; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Effect of protein kinase C inhibitors on invasiveness of human melanoma clones expressing different levels of protein kinase C isoenzymes.
Topics: Alkaloids; Cell Movement; Diglycerides; Humans; Isoenzymes; Melanoma; Neoplasm Invasiveness; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Density-dependent induction of 92-kd type IV collagenase activity in cultures of A431 human epidermoid carcinoma cells.
Topics: Carcinoma, Squamous Cell; Cell Count; Cell Division; Collagenases; Drug Synergism; Enzyme Induction; Humans; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured | 1994 |
Thyrotropin stimulates invasion and growth of follicular thyroid cancer cells via PKC- rather than PKA-activation.
Topics: Alkaloids; Cell Division; Cholera Toxin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; Humans; Neoplasm Invasiveness; Pertussis Toxin; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Thyrotropin; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1993 |
TPA-enhanced invasion of Matrigel associated with augmentation of cell motility but not metalloproteinase activity in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenocarcinoma; Alkaloids; Animals; Cell Membrane; Cell Movement; Collagen; Drug Combinations; Glycoproteins; Humans; Laminin; Metalloendopeptidases; Mice; Mice, Nude; Neoplasm Invasiveness; Protein Kinase C; Proteoglycans; Rectal Neoplasms; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1993 |
v-jun oncogene suppresses both phorbol ester-induced cell invasion and stromelysin gene expression in a mouse papilloma cell line.
Topics: Animals; Gene Expression Regulation, Neoplastic; Genes, jun; Matrix Metalloproteinase 3; Metalloendopeptidases; Mice; Neoplasm Invasiveness; Papilloma; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1994 |
Effect of reactive oxygen intermediates on the in vitro invasive capacity of tumor cells and liver metastasis in mice.
Topics: Animals; Catalase; Electron Spin Resonance Spectroscopy; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred Strains; Neoplasm Invasiveness; Reactive Oxygen Species; Recombinant Proteins; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells.
Topics: Base Sequence; Binding Sites; Collagenases; DNA; Gene Expression Regulation, Enzymologic; Humans; Matrix Metalloproteinase 9; Molecular Sequence Data; Neoplasm Invasiveness; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; TATA Box; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transcriptional Activation; Tumor Necrosis Factor-alpha | 1993 |
Genes related to growth and invasiveness are repressed by sodium butyrate in ovarian carcinoma cells.
Topics: Adenylyl Cyclases; Butyrates; Butyric Acid; Cell Division; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclin D1; Cyclins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Intercellular Signaling Peptides and Proteins; Isoquinolines; Neoplasm Invasiveness; Oncogene Proteins; Oncogenes; Ovarian Neoplasms; Protein Kinase C; Proteins; RNA, Messenger; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1996 |
Tamoxifen antagonizes proliferation and invasion of estrogen receptor-negative metastatic follicular thyroid cancer cells via protein kinase C.
Topics: Alkaloids; Antineoplastic Agents, Hormonal; Cell Division; Drug Interactions; Enzyme Inhibitors; Estrogen Antagonists; Humans; Lung Neoplasms; Neoplasm Invasiveness; Protein Kinase C; Receptors, Estrogen; Staurosporine; Tamoxifen; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Tumor Cells, Cultured | 1996 |
Behavior of the basement membrane during carcinoma cell invasion in chemically induced carcinomas of the skin.
Topics: Animals; Basement Membrane; Benzo(a)pyrene; Collagen; Collagenases; Female; Immunohistochemistry; Integrin alpha6beta1; Integrins; Laminin; Matrix Metalloproteinase 9; Mice; Neoplasm Invasiveness; Receptors, Laminin; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1996 |
Evidence that intracellular phosphatidate may regulate breast cancer cell invasion and metastasis.
Topics: Breast Neoplasms; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Intracellular Fluid; Neoplasm Invasiveness; Phosphatidic Acids; Phospholipase D; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
The pleiotropic effect of TPA on in vitro invasion/migration of glioma and melanoma cell lines.
Topics: Animals; Carcinogens; Cell Movement; Down-Regulation; Glioma; Humans; Isoenzymes; Melanoma; Neoplasm Invasiveness; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Activation of G-proteins with AIF-4 induces LFA-1-mediated adhesion of T-cell hybridoma cells to ICAM-1 by signal pathways that differ from phorbol ester- and manganese-induced adhesion.
Topics: Aluminum Compounds; Androstadienes; Animals; Cell Adhesion; Enzyme Activation; Enzyme Inhibitors; Estrenes; Fluorides; Genistein; GTP-Binding Proteins; Humans; Hybridomas; Indoles; Intercellular Adhesion Molecule-1; Isoflavones; Lymphocyte Function-Associated Antigen-1; Maleimides; Manganese; Mice; Neoplasm Invasiveness; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Diacylglycerol-Lyase; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Protein-Tyrosine Kinases; Pyrrolidinones; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Wortmannin | 1997 |
The high affinity alphaIIb beta3 integrin is involved in invasion of human melanoma cells.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adult; Antibodies, Monoclonal; Blotting, Northern; Blotting, Southern; Cell Adhesion; Epitopes; Female; Fibronectins; Fluorescent Antibody Technique, Indirect; Humans; Immunohistochemistry; Melanoma; Microscopy, Confocal; Neoplasm Invasiveness; Oligopeptides; Platelet Glycoprotein GPIIb-IIIa Complex; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
A GPIb alpha-related protein is expressed by fresh human breast carcinoma tissue and is regulated by a PKC-sensitive mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Breast; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Enzyme Inhibitors; Female; Humans; Immunohistochemistry; Kinetics; Neoplasm Invasiveness; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Protein Kinase C; Reference Values; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Interrelation of motility, cytoskeletal organization and gap junctional communication with invasiveness of melanocytic cells in vitro.
Topics: Actins; Animals; Cell Communication; Cell Division; Cell Movement; Chick Embryo; Cholera Toxin; Culture Media, Serum-Free; Cytoskeleton; Gap Junctions; Heart; Image Processing, Computer-Assisted; Melanocytes; Melanoma; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mitogens; Neoplasm Invasiveness; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vinculin | 1997 |
Breast cancer cell invasiveness: correlation with protein kinase C activity and differential regulation by phorbol ester in estrogen receptor-positive and -negative cells.
Topics: Breast Neoplasms; Carcinoma; Chemotaxis; Collagen; Drug Combinations; Female; Humans; In Vitro Techniques; Laminin; Neoplasm Invasiveness; Protein Kinase C; Proteoglycans; Receptors, Estrogen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
PMA-induced reduction in invasiveness is associated with hyperphosphorylation of MARCKS and talin in invasive bladder cancer cells.
Topics: Actins; Cadherins; Cell Membrane; Cell Movement; Extracellular Matrix; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Neoplasm Invasiveness; Phosphorylation; Protein Kinase C; Proteins; Talin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Vinculin | 1998 |
Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Collagenases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Head and Neck Neoplasms; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 1; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1998 |
Regulation of tissue-degrading factors and in vitro invasiveness in progression of breast cancer cells.
Topics: Breast Neoplasms; Cell Movement; Extracellular Matrix; Female; Gene Expression Regulation, Neoplastic; Humans; Metalloendopeptidases; Neoplasm Invasiveness; Plasminogen Activator Inhibitor 1; Protein Kinase C; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1998 |
Activation of tissue-factor gene expression in breast carcinoma cells by stimulation of the RAF-ERK signaling pathway.
Topics: Base Sequence; Benzoquinones; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Dactinomycin; DNA, Complementary; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Genistein; Humans; Hydroquinones; Lactams, Macrocyclic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neovascularization, Pathologic; NF-kappa B; Okadaic Acid; Phenols; Proto-Oncogene Proteins c-raf; Quinones; Rifabutin; Signal Transduction; Tetradecanoylphorbol Acetate; Thromboplastin; Transcription Factor AP-1; Transcription, Genetic; Tretinoin; Tumor Cells, Cultured | 1998 |
Induction of matrix metalloproteinase-9 requires a polymerized actin cytoskeleton in human malignant glioma cells.
Topics: Actins; Biopolymers; Brain Neoplasms; Cell Adhesion Molecules; Collagenases; Cytochalasin D; Cytoskeleton; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glioma; Humans; Matrix Metalloproteinase 9; Neoplasm Invasiveness; NF-kappa B; Protein Kinase C; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
The effect of protein kinase C inhibitors on invasion of human ovary cancer cells.
Topics: Aged; Cell Adhesion; Cell Movement; Collagen; Down-Regulation; Enzyme Inhibitors; Female; Fibronectins; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Ovarian Neoplasms; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Protein kinase C-alpha activity inversely modulates invasion and growth of intestinal cells.
Topics: Animals; Cadherins; Carbazoles; Cell Adhesion; Cell Movement; Cell Size; Gene Expression Regulation, Neoplastic; Humans; Indoles; Maleimides; Mice; Mice, Nude; Mutagenesis, Site-Directed; Neoplasm Invasiveness; Neoplasms, Experimental; Protein Kinase C; Tetradecanoylphorbol Acetate; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1998 |
Regulation of motility and protease expression in PKC-mediated induction of MCF-7 breast cancer cell invasiveness.
Topics: Breast Neoplasms; Bryostatins; Cathepsin D; Cell Movement; Endopeptidases; Enzyme Activation; Humans; Lactones; Macrolides; Metalloendopeptidases; Neoplasm Invasiveness; Protein Kinase C; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1999 |
Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Crosses, Genetic; Female; Immunity, Innate; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Neoplasm Invasiveness; Neoplasm Staging; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha | 1999 |
Activation of proMMP-9 by a plasmin/MMP-3 cascade in a tumor cell model. Regulation by tissue inhibitors of metalloproteinases.
Topics: Basement Membrane; Breast Neoplasms; Collagenases; Enzyme Activation; Enzyme Precursors; Female; Fibrinolysin; Humans; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Models, Biological; Neoplasm Invasiveness; Recombinant Proteins; Sequence Deletion; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured | 1999 |
TPA-enhanced motility and invasion in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1: selective role of PKC-alpha and its inhibition by a combination of PDBu-induced PKC downregulation and antisense oligonucleotides trea
Topics: Adenocarcinoma; Base Sequence; Carbazoles; Down-Regulation; Humans; Indoles; Isoenzymes; Naphthalenes; Neoplasm Invasiveness; Neoplasm Metastasis; Oligonucleotides, Antisense; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Protein Kinase C-alpha; Rectal Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Altered actin cytoskeleton and inhibition of matrix metalloproteinase expression by vanadate and phenylarsine oxide, inhibitors of phosphotyrosine phosphatases: modulation of migration and invasion of human malignant glioma cells.
Topics: Actins; Arsenicals; Cell Adhesion Molecules; Cell Movement; Cytoskeleton; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Neoplastic; Glioma; Humans; Matrix Metalloproteinases; Neoplasm Invasiveness; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vanadates | 1999 |
Ras pathway is required for the activation of MMP-2 secretion and for the invasion of src-transformed 3Y1.
Topics: Androstadienes; Animals; Cell Line, Transformed; Clone Cells; Enzyme Activation; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Polyenes; Polyunsaturated Alkamides; Proto-Oncogene Proteins pp60(c-src); ras Proteins; Rats; Tetradecanoylphorbol Acetate; Wortmannin | 1999 |
Urokinase (u-PA) and the u-PA receptor. Modulation of in vitro invasiveness of human bladder cancer cell lines.
Topics: Basement Membrane; Collagen; Drug Combinations; Epidermal Growth Factor; Humans; Interferon-gamma; Laminin; Neoplasm Invasiveness; Neoplasm Metastasis; Proteoglycans; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Urokinase-Type Plasminogen Activator | 1999 |
Phorbol 12-myristate 13-acetate induces alteration in mucin gene expression and biological properties of colon cancer cells.
Topics: Adenocarcinoma; Antigens, Neoplasm; Carcinogens; Cell Adhesion; Cell Movement; Collagen; Colonic Neoplasms; Drug Combinations; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Laminin; Metalloendopeptidases; Mucin 5AC; Mucin-2; Mucin-3; Mucins; Naphthalenes; Neoplasm Invasiveness; Neoplasm Proteins; Protein Kinase C; Proteoglycans; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Protein kinase C activation by phorbol ester increases in vitro invasion through regulation of matrix metalloproteinases/tissue inhibitors of metalloproteinases system in D54 human glioblastoma cells.
Topics: Brain Neoplasms; Glioblastoma; Humans; Matrix Metalloproteinases; Neoplasm Invasiveness; Phorbol Esters; Protein Kinase C; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured | 2000 |
Suppression of urokinase expression and invasiveness by urinary trypsin inhibitor is mediated through inhibition of protein kinase C- and MEK/ERK/c-Jun-dependent signaling pathways.
Topics: Cell Movement; Glycoproteins; Humans; MAP Kinase Signaling System; Neoplasm Invasiveness; Phosphorylation; Protein Kinase C; Protein Transport; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 2001 |
KiSS-1 represses 92-kDa type IV collagenase expression by down-regulating NF-kappa B binding to the promoter as a consequence of Ikappa Balpha -induced block of p65/p50 nuclear translocation.
Topics: Active Transport, Cell Nucleus; Cell Nucleus; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; I-kappa B Proteins; JNK Mitogen-Activated Protein Kinases; Kisspeptins; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinases; Molecular Weight; Neoplasm Invasiveness; NF-kappa B; NF-KappaB Inhibitor alpha; Polymerase Chain Reaction; Promoter Regions, Genetic; Proteins; Recombinant Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tumor Suppressor Proteins | 2001 |
Adherence to osteopontin via alphavbeta3 suppresses phorbol ester-mediated apoptosis in MCF-7 breast cancer cells that overexpress protein kinase C-alpha.
Topics: Adenocarcinoma; Antigens, CD; Apoptosis; Bone Neoplasms; Breast Neoplasms; Cell Adhesion; Enzyme Induction; Extracellular Matrix Proteins; Female; Gene Expression Regulation, Neoplastic; Humans; Integrin beta3; Isoenzymes; Neoplasm Invasiveness; Neoplasm Proteins; Oligopeptides; Osteopontin; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Kinase C-alpha; Receptors, Vitronectin; Sialoglycoproteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Myoepithelial-specific CD44 shedding contributes to the anti-invasive and antiangiogenic phenotype of myoepithelial cells.
Topics: Antigens, CD; Breast Neoplasms; Carcinoma; Culture Media, Conditioned; Epithelial Cells; Female; Humans; Hyaluronan Receptors; Neoplasm Invasiveness; Neovascularization, Pathologic; Protease Inhibitors; Protein Isoforms; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1; Tumor Cells, Cultured; Tunicamycin | 2000 |
Type IV collagen induces matrix metalloproteinase 2 activation in HT1080 fibrosarcoma cells.
Topics: Collagen; Concanavalin A; Culture Media, Conditioned; Extracellular Matrix Proteins; Fibrosarcoma; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Neoplasm Invasiveness; Protein Biosynthesis; Protein Precursors; RNA, Messenger; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-2; Tumor Cells, Cultured | 2000 |
Invasiveness and MMP expression in pancreatic carcinoma.
Topics: Biocompatible Materials; Carcinoma; Collagen; Concanavalin A; Drug Combinations; Extracellular Matrix; Gels; Gene Expression Regulation, Neoplastic; Humans; Laminin; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Neoplasm Invasiveness; Pancreatic Neoplasms; Proteoglycans; Reverse Transcriptase Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured | 2001 |
Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas.
Topics: Base Sequence; Binding Sites; Brain Neoplasms; Electrophoretic Mobility Shift Assay; Enhancer Elements, Genetic; Gene Expression Regulation, Neoplastic; Genes, Reporter; Glioma; Glycoproteins; Humans; Luciferases; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasm Proteins; Promoter Regions, Genetic; Recombinant Fusion Proteins; Sequence Deletion; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2002 |
Expression and regulation of Cyr61 in human breast cancer cell lines.
Topics: Active Transport, Cell Nucleus; Adenocarcinoma; Breast Neoplasms; Calcitriol; Cysteine-Rich Protein 61; Drug Resistance; Estradiol; Estrogen Receptor Modulators; Estrogens; Female; Fulvestrant; Gene Expression Regulation, Neoplastic; Genes, Immediate-Early; Growth Substances; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Phenotype; Protein Structure, Tertiary; Receptors, Estrogen; RNA, Messenger; RNA, Neoplasm; Selective Estrogen Receptor Modulators; Tamoxifen; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection; Tretinoin; Tumor Cells, Cultured | 2002 |
Dissimilar invasive and metastatic behavior of vincristine and doxorubicin-resistant cell lines derived from a murine T cell lymphoid leukemia.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Cell Division; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Hyaluronan Receptors; Hyaluronic Acid; Lymphoma, T-Cell; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Transplantation; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vincristine | 2002 |
A tobacco-specific N-nitrosamine or cigarette smoke condensate causes neoplastic transformation of xenotransplanted human bronchial epithelial cells.
Topics: Animals; Biomarkers, Tumor; Bronchi; Carcinogens; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Chemotaxis; Epithelium; ErbB Receptors; Gelatinases; Humans; Isoenzymes; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Invasiveness; Nitrosamines; Pepsin A; Rats; Smoke; Smoking; Tetradecanoylphorbol Acetate; Trachea; Transforming Growth Factor alpha; Transplantation, Heterologous | 1992 |
Tumor necrosis factor stimulates epithelial tumor cell motility.
Topics: Animals; Cell Line; Cell Movement; Chemotaxis; Cytokines; Dogs; Dose-Response Relationship, Drug; Epithelium; Fibroblast Growth Factor 2; Hepatocyte Growth Factor; Humans; In Vitro Techniques; Interleukin-2; Interleukin-6; Macrophage Colony-Stimulating Factor; Neoplasm Invasiveness; Neoplasms; Rats; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha | 1991 |
Differential effects of phorbol ester on the in vitro invasiveness of malignant and non-malignant human fibroblast cells.
Topics: Blotting, Western; Cell Movement; Diglycerides; Down-Regulation; Fibroblasts; Fibrosarcoma; Humans; Microbial Collagenase; Neoplasm Invasiveness; Phorbol Esters; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Adenovirus E1A represses protease gene expression and inhibits metastasis of human tumor cells.
Topics: Adenovirus Early Proteins; Base Sequence; Cell Transformation, Neoplastic; Chloramphenicol O-Acetyltransferase; DNA-Binding Proteins; Gene Expression; Humans; Metalloendopeptidases; Microbial Collagenase; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasm Metastasis; Oncogene Proteins, Viral; Peptide Hydrolases; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Transfection | 1990 |
Enhancement of the invasive ability of a transformed human bronchial epithelial cell line by 12-O-tetradecanoyl-phorbol-13-acetate and diacylglycerol.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Chemotaxis; Diglycerides; Epithelium; Glycerides; Humans; Lung; Mice; Mice, Nude; Microbial Collagenase; Neoplasm Invasiveness; Neoplasm Transplantation; Rats; Tetradecanoylphorbol Acetate; Trachea; Transplantation, Heterologous | 1989 |
Transcription from the stromelysin promoter is induced by interleukin-1 and repressed by dexamethasone.
Topics: Animals; Arthritis, Rheumatoid; Base Sequence; Cholera Toxin; Cyclic AMP; Dexamethasone; Epidermal Growth Factor; Gene Expression Regulation; Interleukin-1; Matrix Metalloproteinase 3; Metalloendopeptidases; Molecular Sequence Data; Neoplasm Invasiveness; Promoter Regions, Genetic; Rabbits; Repetitive Sequences, Nucleic Acid; Tetradecanoylphorbol Acetate; Transcription, Genetic; Wound Healing | 1987 |
Collagenase and elastase production by mouse mammary adenocarcinoma primary cultures and cloned cells.
Topics: Adenocarcinoma; Animals; Cells, Cultured; Clone Cells; Collagen; Female; Mammary Neoplasms, Experimental; Mice; Microbial Collagenase; Neoplasm Invasiveness; Neoplasm Metastasis; Pancreatic Elastase; Tetradecanoylphorbol Acetate | 1986 |
Tissue culture model of adenoma invasion implicating diglycerides from fecal fat degradation as promoting agents.
Topics: Adenoma; Animals; Colonic Neoplasms; Culture Techniques; Dietary Fats; Diglycerides; Feces; Glycerides; Microscopy, Phase-Contrast; Neoplasm Invasiveness; Tetradecanoylphorbol Acetate | 1988 |
Tissue culture model of adenoma invasion.
Topics: Adenoma; Benzamidines; Carcinoma; Colonic Neoplasms; Culture Techniques; Humans; Models, Biological; Neoplasm Invasiveness; Tetradecanoylphorbol Acetate; Urokinase-Type Plasminogen Activator | 1987 |