tetradecanoylphorbol acetate has been researched along with Granulocytic Leukemia, Chronic in 76 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (11.84) | 18.7374 |
| 1990's | 51 (67.11) | 18.2507 |
| 2000's | 12 (15.79) | 29.6817 |
| 2010's | 4 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Banaszak, LG; Gao, SG; Gutierrez-Rodrigues, F; Kajigaya, S; Keyvanfar, K; Quinones Raffo, D; Wu, ZJ; Young, NS; Zhao, X | 1 |
| Cen, J; Chen, Y; Chen, Z; Ding, X; Qi, X; Shen, H; Wang, Y; Yao, L | 1 |
| Hatake, K; Kimura, S; Kuniyoshi, R; Mishima, Y; Ozawa, K; Takizawa, T; Taniyama, A; Terui, Y | 1 |
| Goto, H; Kajiwara, R; Naruto, T; Nishimaki, S; Tanaka, F; Yanagimachi, M; Yokosuka, T; Yokota, S | 1 |
| Auberger, P; Cassuto, JP; Colosetti, P; Gounon, P; Jacquel, A; Luciano, F; Puissant, A; Robert, G | 1 |
| Miyamoto, S; Nakashima, M; Sonoda, K; Wake, N | 1 |
| Goodfellow, SJ; Medler, KF; Rebello, MR; Roberts, SG; Rudd, SG; Toska, E; Zeef, LA | 1 |
| Herbst, R; Pettiford, SM | 1 |
| Ayala, E; Beazer-Barclay, Y; Carlson, LM; Hnatyszyn, JH; Kharfan-Dabaja, MA; Kolonias, D; Lee, KP; Lindner, I; Scherf, U | 1 |
| Bártová, E; Harnicarová, A; Kozubek, S; Pacherník, J | 1 |
| Cao, G; Fang, B; Han, Z; Li, D; Lin, Q; Liu, X; Nie, N; Shi, Y; Song, Y; Sun, J; Tian, G; Wei, X; Yang, R; Zhao, RC; Zhu, X | 1 |
| Abe, Y; Han, JK; Isoda, H; Talorete, TP; Yamada, P | 1 |
| Andreeff, M; Collins, SJ; Drach, J; Engel, H; Malavasi, F; McQueen, T; Mehta, K; Robertson, KA | 1 |
| Ascione, AG; Demple, B; Harrison, L; Wilson, DM | 1 |
| Barbera, E; Cardier, J; Cheng, T; Dai, W; Dempsey, J; Erickson-Miller, CL; Li, C; Mogle, M; Murphy, MJ; Wang, Y | 1 |
| Aschauer, B; Bach, FH; Chu, CT; Düchler, M; Hofer, E; Holzmüller, H; Lipp, J; Offterdinger, M | 1 |
| Asai, T; Itoh, K; Oh, H; Wakita, H; Yoshida, S | 1 |
| Brizard, A; de LaForest, PG; Delwail, V; Guilhot, F; Lecron, JC; Meseri, A; Morel, F | 1 |
| Cha, Y; Deisseroth, AB; Gambel, AM; Grasso, L; McClain, CD; Mercer, WE; Travali, S; Zhang, W | 1 |
| Abe, A; Adachi, K; Emi, N; Kato, H; Kojima, T; Morishita, N; Murate, T; Ogura, M; Saga, S; Tanimoto, M | 1 |
| Berg, A; Le Blanc, K; Palmblad, J; Samuelsson, J | 1 |
| Forslid, J; Hed, J; Palmblad, J; Samuelsson, J | 1 |
| Clark, J; Iwata, K; Lasky, SR; Maizel, AL; Posner, MR; Samuel, V; Santos-Moore, A; Yen, A | 1 |
| Abraham, NG; Kappas, A; Lavrovsky, Y; Levere, RD; Schwartzman, ML | 1 |
| Hashimoto, Y; Iwasaki, S; Nishimura, K | 1 |
| Advani, S; Batliwalla, F; Gothoskar, B; Zingde, S | 1 |
| Chistokhina, AV; Medvedev, AV | 1 |
| Aoki, S; Furukawa, T; Gotoh, T; Hanano, M; Hashimoto, S; Kishi, K; Koike, T; Saitoh, H; Shinada, S; Ying, W | 1 |
| Platko, JD; Varvayanis, S; Yen, A | 1 |
| Savage, N; Weitzmann, MN | 1 |
| Back, AL; Baker, DM; Embree, LJ; Gollahon, KA; Grunvald, E; Hickstein, DD; Shumaker, G; Yee, E | 1 |
| Chan, BM; Hemler, ME | 1 |
| Chambers, TC; Chiou, SH; Kuo, JF; Raynor, RL; Zheng, B | 1 |
| Liuzzo, JP; Moscatelli, D | 1 |
| Herwig, S; Ma, Y; Su, Q; Tempst, P; Zhang, W | 1 |
| Cossman, J; Irving, SG; Kamesaki, H; Kamesaki, S; Michaud, GY; Okuma, M; Suwabe, N | 1 |
| Khaled, Z; Maltese, JY; Narayanan, R; Nichols, G; Perez, JR; Sartorelli, AC; Sharma, HW; Sokoloski, JA; Stein, CA; Telang, NT | 1 |
| Eggett, T; Holguin, MH; Martin, CB; Parker, CJ | 1 |
| Honma, Y; Miyoshi, H; Niitsu, N; Ohki, M; Shimizu, K; Umeda, M; Yamamoto-Yamaguchi, Y | 1 |
| Boucheix, C; Francastel, C; Lantz, O; Le Naour, F; Prenant, M; Rubinstein, E | 1 |
| Del Vecchio, L; Di Noto, R; Ferrara, F; Frigeri, F; Lo Pardo, C; Lombardi, ML; Luciano, L; Manzo, C; Mercuro, O; Pane, F; Rotoli, B; Salvatore, F; Vacca, C | 1 |
| Ezawa, H; Harigaya, K; Ishii, G; Mikata, A; Nakajima, N | 1 |
| Fujinuma, H; Fujita, T; Motokura, T; Taniguchi, T; Uchimaru, K; Yoshikawa, M | 1 |
| Hagiwara, S; Iki, S; Miwa, A; Ozawa, K; Saeki, K; Takaku, F; Togawa, A; Urabe, A; Yuo, A | 1 |
| Bando, S; Fujita, S; Kaneko, M; Kohno, H; Ohminami, H; Sada, E; Yakushijin, Y; Yanagisawa, K; Yasukawa, M | 1 |
| García, J; Martín-Henao, GA; Quiroga, R; Sureda, A | 1 |
| Fujimoto, Y; Hashimoto, Y; Koiso, Y; Matsumura, D; Nakajima, O | 1 |
| Fritsche, H; Johnson, H; Kantarjian, HM; Lee, BN; Reuben, JM; Talpaz, M | 1 |
| Bitan, M; Deutsch, V; Eldor, A; Friedmann, Y; Vlodavsky, I | 1 |
| Andrews, RB; Baker, EJ; Bamberger, EG; Day, NE; Ichiki, AT; Lozzio, CB | 1 |
| Blobe, GC; Hannun, YA; Karolak, LA; Obeid, LM | 1 |
| Brautigan, DL; Buzzi, M; Fast, LD; Frackelton, AR; Lombardi, AJ; Lu, L; Posner, MR | 1 |
| Fujiwara, Y; Kasahara, K; Kubo, S; Niitani, H; Nishio, K; Saijo, N; Sugimoto, Y; Takeda, Y | 1 |
| Hotta, T; Murate, T; Saga, S; Saito, H; Suzuki, M; Tsushita, K; Yoshida, S; Yoshida, T | 1 |
| Civin, CI; Craig, RW; Kastan, MB; Kuerbitz, SJ; Onyekwere, O; Radin, AI; Ravindranath, Y; Stone, KD; Wolkow, CA; Woo, T | 1 |
| Chang, WC; Hsiao, MH; Pattengale, PK | 1 |
| Chen, ZX; Wu, WL | 1 |
| Farrar, WL; Harel-Bellan, A; Robin, P; Sassone-Corsi, P; Trouche, D | 1 |
| Arndt, A; Hart, DA; Rehemtulla, A | 1 |
| Kirito, K; Nakamura, M; Nojiri, H; Saito, M; Wainai, T; Yamanoi, J | 1 |
| Irino, S; Kubota, Y; Tanaka, T | 1 |
| Kharbanda, SM; Kufe, DW; Sherman, ML | 1 |
| Bollum, FJ; Minowada, J; Miura, Y; Sasaki, R | 1 |
| Alitalo, K; Alitalo, R; Andersson, L; Hölttä, E; Partanen, J; Pertovaara, L; Sistonen, L | 1 |
| Endo, T; Fukumaki, Y; Hirata, J; Katsuno, M; Masuda, S; Nishimura, J; Sasaki, R; Sato, H; Shiokawa, S; Takahira, H | 1 |
| Bütler, TM; Friis, RR; Ziemiecki, A | 1 |
| Alitalo, R | 1 |
| Alitalo, R; Andersson, LC; Sistonen, L; Stephens, R; Tapiovaara, H; Vaheri, A | 1 |
| Chen, ZX; Wang, W; Wu, WL | 1 |
| Beuzard, Y; Casadevall, N; Debili, N; Dubart, A; Kishi, K; Mayeux, P; Mitjavila, MT; Nakazawa, M; Roméo, PH; Rouyer-Fessard, P | 1 |
| Bainton, DF; Hibbs, MS | 1 |
| Courtois, P; Ferster, A; Fondu, P; Mandelbaum, IM | 1 |
| Ackerman, JJ; Duerre, JA | 1 |
| Arlinghaus, RB; Kabat, KG; Kloetzer, WS; Li, WJ; Smith, LA | 1 |
| Holland, JF; Ohnuma, T; Zinzar, S | 1 |
| Hayashi, M; Hino, K; Honma, Y; Hozumi, M; Okabe-Kado, J; Sakurai, M; Sampi, K; Tsuruoka, N | 1 |
2 review(s) available for tetradecanoylphorbol acetate and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
[Chemical control of cell differentiation of human myeloleukemia K562 cell line].
Topics: Cell Differentiation; Erythroblasts; Heme Oxygenase (Decyclizing); Hemin; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Monocytes; Protoporphyrins; Receptors, GABA-A; Retinoids; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 2000 |
Induced differentiation of K562 leukemia cells: a model for studies of gene expression in early megakaryoblasts.
Topics: Cell Differentiation; Cell Line; Fibrinolysis; Gene Expression; Growth Substances; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Megakaryocytes; Tetradecanoylphorbol Acetate | 1990 |
1 trial(s) available for tetradecanoylphorbol acetate and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
Synergistic interactions between 12-0-tetradecanoylphorbol-13-acetate (TPA) and imatinib in patients with chronic myeloid leukemia in blastic phase that is resistant to standard-dose imatinib.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Blast Crisis; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Piperazines; Pyrimidines; Tetradecanoylphorbol Acetate; Treatment Outcome | 2007 |
73 other study(ies) available for tetradecanoylphorbol acetate and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
CRISPR/Cas9-mediated ASXL1 mutations in U937 cells disrupt myeloid differentiation.
Topics: Cell Cycle; Cell Differentiation; Cell Proliferation; CRISPR-Cas Systems; Fluorouracil; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myelomonocytic, Chronic; Mutation; Repressor Proteins; Tetradecanoylphorbol Acetate; Transcriptome; U937 Cells | 2018 |
BMI1 reprogrammes histone acetylation and enhances c-fos pathway via directly binding to Zmym3 in malignant myeloid progression.
Topics: Acetylation; Adolescent; Adult; Aged; Aged, 80 and over; Apoptosis; Blotting, Western; Butyric Acid; Case-Control Studies; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chromatin Immunoprecipitation; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Histamine Antagonists; Histones; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Myelodysplastic Syndromes; Nuclear Proteins; Polycomb Repressive Complex 1; Protein Binding; Proto-Oncogene Proteins c-fos; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Young Adult | 2014 |
Autophagy and autophagic cell death are next targets for elimination of the resistance to tyrosine kinase inhibitors.
Topics: Autophagy; Cell Death; Cell Differentiation; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate | 2008 |
Suppressed neutrophil function in children with acute lymphoblastic leukemia.
Topics: Adolescent; Anemia, Aplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinogens; Child; Child, Preschool; Female; Humans; Immune Tolerance; Infant; Infant, Newborn; Infections; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, Non-Hodgkin; Male; Neutrophils; Phagocytosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purpura, Thrombocytopenic, Idiopathic; Recurrence; Respiratory Burst; Risk Factors; Tetradecanoylphorbol Acetate | 2009 |
Autophagy is an important event for megakaryocytic differentiation of the chronic myelogenous leukemia K562 cell line.
Topics: Autophagy; Cell Differentiation; Humans; Imidazoles; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Megakaryocytes; Pyridines; Tetradecanoylphorbol Acetate; Vacuoles | 2009 |
Receptor-binding cancer antigen expressed on SiSo cells induces apoptosis via ectodomain shedding.
Topics: Antigens, Neoplasm; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Coculture Techniques; Female; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; MAP Kinase Signaling System; Neoplasms; Phosphorylation; Signal Transduction; Tetradecanoylphorbol Acetate; Uterine Neoplasms | 2010 |
WT1 and its transcriptional cofactor BASP1 redirect the differentiation pathway of an established blood cell line.
Topics: Cell Differentiation; Cellular Reprogramming; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Proteins; Multigene Family; Nerve Tissue Proteins; Neurites; Neurogenesis; Neurons; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Repressor Proteins; RNA, Messenger; Signal Transduction; Synapses; Tetradecanoylphorbol Acetate; Transcriptional Activation; WT1 Proteins | 2011 |
The protein tyrosine phosphatase HePTP regulates nuclear translocation of ERK2 and can modulate megakaryocytic differentiation of K562 cells.
Topics: Active Transport, Cell Nucleus; Antigens, CD; Cell Cycle; Cell Differentiation; DNA, Antisense; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Megakaryocytes; Mitogen-Activated Protein Kinase 1; Platelet Membrane Glycoprotein IIb; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; Tetradecanoylphorbol Acetate; Transfection | 2003 |
Induced dendritic cell differentiation of chronic myeloid leukemia blasts is associated with down-regulation of BCR-ABL.
Topics: Blast Crisis; Calcium; Cell Differentiation; Cell Division; Cell Lineage; Cells, Cultured; Cytokines; Dendritic Cells; Down-Regulation; Enzyme Activation; Fusion Proteins, bcr-abl; Gene Expression Regulation, Neoplastic; Genes, abl; Humans; Intracellular Fluid; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcr; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2003 |
Nuclear topography and expression of the BCR/ABL fusion gene and its protein level influenced by cell differentiation and RNA interference.
Topics: Antigens, Surface; Apoptosis; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Down-Regulation; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Sequence Data; RNA Interference; Tetradecanoylphorbol Acetate | 2005 |
Inhibitory effect of fulvic acid extracted from Canadian sphagnum peat on chemical mediator release by RBL-2H3 and KU812 cells.
Topics: Animals; Anti-Allergic Agents; Antigen-Antibody Complex; Antigens; Basophils; Benzopyrans; beta-N-Acetylhexosaminidases; Calcimycin; Calcium; Cell Line, Tumor; Dose-Response Relationship, Drug; Fluorescent Dyes; Formazans; Histamine Release; Humans; Immunoglobulin E; Ionophores; Leukemia, Basophilic, Acute; Leukemia, Experimental; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Nuclear Magnetic Resonance, Biomolecular; p-Methoxy-N-methylphenethylamine; Plant Extracts; Rats; Spectroscopy, Fourier Transform Infrared; Sphagnopsida; Tetradecanoylphorbol Acetate; Tetrazolium Salts | 2007 |
Retinoic acid-induced expression of CD38 antigen in myeloid cells is mediated through retinoic acid receptor-alpha.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Antigens, CD; Antigens, Differentiation; Bone Marrow; Cell Differentiation; Cell Line; Clone Cells; Dose-Response Relationship, Drug; Drug Resistance; Flow Cytometry; Gene Expression; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Granulocytes; Hematopoietic Stem Cells; Humans; Interferon-gamma; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Promyelocytic, Acute; Membrane Glycoproteins; Receptors, Retinoic Acid; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tretinoin; Tumor Cells, Cultured | 1994 |
Characterization of the promoter region of the human apurinic endonuclease gene (APE).
Topics: Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Line; Chloramphenicol O-Acetyltransferase; Deoxyribonuclease IV (Phage T4-Induced); DNA Primers; DNA Probes; DNA-(Apurinic or Apyrimidinic Site) Lyase; Gene Deletion; Gene Expression; HeLa Cells; Hominidae; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liver Neoplasms; Lyases; Molecular Sequence Data; Oligodeoxyribonucleotides; Promoter Regions, Genetic; Restriction Mapping; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1995 |
HIMeg-1, a cell line derived from a CML patient, is capable of monocytic and megakaryocytic differentiation.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antigens, Surface; Blotting, Northern; Cell Differentiation; Cell Division; Cell Separation; Culture Media; DNA-Binding Proteins; Early Growth Response Protein 1; Flow Cytometry; Humans; Immediate-Early Proteins; Integrin alphaXbeta2; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lipopolysaccharide Receptors; Lymphocyte Activation; Megakaryocytes; Monocytes; Retroviridae Proteins, Oncogenic; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 1995 |
NKG2-C is a receptor on human natural killer cells that recognizes structures on K562 target cells.
Topics: Animals; Calcium; Cell Differentiation; Cell Line; Cytotoxicity, Immunologic; DNA, Complementary; Dogs; Glycosylation; Humans; Ionomycin; Killer Cells, Natural; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Glycoproteins; Membrane Proteins; Neoplasm Proteins; NK Cell Lectin-Like Receptor Subfamily C; Nucleopolyhedroviruses; Receptors, Immunologic; Receptors, Natural Killer Cell; Recombinant Fusion Proteins; Spodoptera; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Chemiluminescence of neutrophils in patients with myeloproliferative or myelodysplastic hematologic diseases--relation to neutrophil alkaline phosphatase activity.
Topics: Alkaline Phosphatase; Cells, Cultured; Granulocyte Colony-Stimulating Factor; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukocyte Count; Luminescent Measurements; Myelodysplastic Syndromes; Myeloproliferative Disorders; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Tetradecanoylphorbol Acetate; Thrombocythemia, Essential | 1993 |
Effects of sCD23 on proliferation of leukemic cells from a patient with chronic myelogenous leukemia during blast crisis.
Topics: Acute-Phase Reaction; Blast Crisis; Cell Division; Female; Flow Cytometry; Hematopoietic Cell Growth Factors; Humans; Interleukin-1; Interleukin-3; Interleukin-7; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Middle Aged; Phenotype; Receptors, IgE; Stem Cell Factor; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1993 |
p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation.
Topics: Blotting, Northern; Cell Cycle; Cell Differentiation; Cell Division; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA, Neoplasm; Electroporation; Flow Cytometry; Gene Expression; Genes, p53; Granulocytes; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Monocytes; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1995 |
Establishment and characterization of an immature human megakaryoblastic cell line, MEG-A2.
Topics: Adult; Aneuploidy; Antigens, CD; Antigens, Differentiation; Base Sequence; beta-Thromboglobulin; Biomarkers, Tumor; Blast Crisis; Carboxylic Ester Hydrolases; Cell Division; Fatal Outcome; Gene Expression Regulation, Leukemic; Hematopoietic Cell Growth Factors; Hematopoietic Stem Cells; Humans; Karyotyping; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Megakaryocytes; Molecular Sequence Data; Neoplasm Proteins; Neoplastic Stem Cells; Platelet Factor 4; Platelet Membrane Glycoproteins; Protein S; Proto-Oncogene Proteins; Receptors, Cytokine; Receptors, Immunologic; Receptors, Thrombopoietin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Stimulus-specific defect in platelet aggregation in polycythemia vera.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Blood Platelets; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Luminescent Measurements; Middle Aged; Multiple Myeloma; Platelet Activating Factor; Platelet Aggregation; Polycythemia Vera; Tetradecanoylphorbol Acetate | 1994 |
Studies of neutrophil and monocyte oxidative responses in polycythaemia vera and related myeloproliferative disorders.
Topics: Adult; Aged; Humans; Hydrogen Peroxide; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Luminescent Measurements; Middle Aged; Monocytes; Myeloproliferative Disorders; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Polycythemia Vera; Tetradecanoylphorbol Acetate; Thrombocythemia, Essential | 1994 |
Characterization of a vitamin D3-resistant human chronic myelogenous leukemia cell line.
Topics: Base Sequence; Calcitriol; Cell Differentiation; Cell Division; DNA, Neoplasm; Drug Resistance; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Sequence Data; Neoplasm Proteins; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Receptors, Calcitriol; Retinoblastoma Protein; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene.
Topics: Animals; Base Sequence; Binding Sites; Cell Line; Deoxyribonuclease I; DNA Primers; DNA-Binding Proteins; Enzyme Induction; Gene Expression; Heme Oxygenase (Decyclizing); Hominidae; Humans; Isoenzymes; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Metallothionein; Molecular Sequence Data; NF-kappa B; Polymerase Chain Reaction; Promoter Regions, Genetic; Restriction Mapping; TATA Box; Tetradecanoylphorbol Acetate; Transcription Factor AP-2; Transcription Factors; Tumor Cells, Cultured | 1994 |
Enhancement of phorbol ester-induced production of tumor necrosis factor alpha by thalidomide.
Topics: Cell Line; Drug Synergism; Humans; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Promyelocytic, Acute; Lymphoma, Large B-Cell, Diffuse; Tetradecanoylphorbol Acetate; Thalidomide; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1994 |
Differential phosphorylation in normal and leukemic granulocytes in response to phorbol 12-myristate 13-acetate.
Topics: Autoradiography; Electrophoresis, Gel, Two-Dimensional; Granulocytes; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leupeptins; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Tetradecanoylphorbol Acetate | 1994 |
[Retinoic acid intensifies the suppression of the proliferation of K562 cells by phorbol ester].
Topics: Cell Division; Depression, Chemical; Dose-Response Relationship, Drug; Drug Synergism; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin; Tumor Cells, Cultured | 1993 |
Establishment of a new cell line with the characteristics of a multipotential progenitor from a patient with chronic myelogenous leukemia in early erythroblastic crisis.
Topics: Aged; Antigens, Surface; Base Sequence; Blast Crisis; Cell Differentiation; Granulocytes; Hemoglobins; Histocytochemistry; Humans; Interleukin-3; Karyotyping; Leukemia, Erythroblastic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Molecular Sequence Data; Peroxidase; Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
12-O-tetradecanoylphorbol-13-acetate and staurosporine induce increased retinoblastoma tumor suppressor gene expression with megakaryocytic differentiation of leukemic cells.
Topics: Alkaloids; Cell Cycle; Cell Differentiation; DNA, Neoplasm; Gene Expression; Gene Expression Regulation, Leukemic; Genes, Retinoblastoma; Humans; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Megakaryocytes; Phosphorylation; Protein Kinase C; Retinoblastoma Protein; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Cyclic adenosine 3',5'-monophosphate, a second messenger in interleukin-1 mediated K562 cytostasis.
Topics: Adenylyl Cyclases; Alkaloids; Bucladesine; Cell Division; Colforsin; Cyclic AMP; Humans; Interleukin-1; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Transfected leukocyte integrin CD11b/CD18 (Mac-1) mediates phorbol ester-activated, homotypic cell:cell adherence in the K562 cell line.
Topics: Cell Adhesion; Genetic Vectors; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Macrophage-1 Antigen; Platelet Membrane Glycoproteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1993 |
Multiple functional forms of the integrin VLA-2 can be derived from a single alpha 2 cDNA clone: interconversion of forms induced by an anti-beta 1 antibody.
Topics: Antibodies, Monoclonal; Cell Adhesion; Cell Line; Cloning, Molecular; DNA; Extracellular Matrix; Humans; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Macromolecular Substances; Receptors, Very Late Antigen; Rhabdomyosarcoma; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1993 |
Cobra venom cardiotoxin (cytotoxin) isoforms and neurotoxin: comparative potency of protein kinase C inhibition and cancer cell cytotoxicity and modes of enzyme inhibition.
Topics: Amino Acid Sequence; Animals; Brain; Cell Differentiation; Cell Survival; Cytotoxins; Elapid Venoms; Humans; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Promyelocytic, Acute; Molecular Sequence Data; Neurotoxins; Phorbol 12,13-Dibutyrate; Protein Kinase C; Sequence Homology, Amino Acid; Structure-Activity Relationship; Swine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Human leukemia cell lines bind basic fibroblast growth factor (FGF) on FGF receptors and heparan sulfates: downmodulation of FGF receptors by phorbol ester.
Topics: Animals; Binding Sites; CHO Cells; Cricetinae; Down-Regulation; Fibroblast Growth Factor 2; Heparan Sulfate Proteoglycans; Heparin; Heparitin Sulfate; HL-60 Cells; Humans; Leukemia; Leukemia, Megakaryoblastic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, Large B-Cell, Diffuse; Megakaryocytes; Neoplasm Proteins; Protein Binding; Proteoglycans; Receptors, Fibroblast Growth Factor; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Distinct temporal patterns of defensin mRNA regulation during drug-induced differentiation of human myeloid leukemia cells.
Topics: Acetamides; Biomarkers; Blood Proteins; Cell Differentiation; Cycloheximide; Cytokines; Dactinomycin; Defensins; Dimethyl Sulfoxide; Dimethylformamide; DNA, Complementary; Enzyme Inhibitors; Gene Expression Regulation, Leukemic; Genistein; Granulocyte Colony-Stimulating Factor; Granulocytes; HL-60 Cells; Humans; Interferon-gamma; Isoflavones; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Lymphocytes; Lymphoma, Large B-Cell, Diffuse; Neoplasm Proteins; Recombinant Proteins; RNA Processing, Post-Transcriptional; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic; Tretinoin; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1996 |
TPA-induced arrest of erythroid differentiation is coupled with downregulation of GATA-1 and upregulation of GATA-2 in an erythroid cell line SAM-1.
Topics: Antigens, Differentiation; Biomarkers; Blast Crisis; Cell Differentiation; DNA-Binding Proteins; Erythroid Precursor Cells; Erythroid-Specific DNA-Binding Factors; Erythropoiesis; GATA2 Transcription Factor; Gene Expression Regulation; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Megakaryocytes; Receptors, Estrogen; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 1996 |
Differentiation of immortal cells inhibits telomerase activity.
Topics: Animals; Base Sequence; Butyrates; Butyric Acid; Calcitriol; Cell Differentiation; Cell Line; Cell Nucleus; Colonic Neoplasms; Cytoplasm; Dimethyl Sulfoxide; Growth Inhibitors; HL-60 Cells; Humans; Interleukin-6; Kidney; Leukemia Inhibitory Factor; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphokines; Mice; Repetitive Sequences, Nucleic Acid; Stem Cells; Telomerase; Teratocarcinoma; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1995 |
Analysis of the gene that encodes the complement regulatory protein, membrane inhibitor of reactive lysis (CD59). Identification of an alternatively spliced exon and characterization of the transcriptional regulatory regions of the promoter.
Topics: Antigens, Neoplasm; CD59 Antigens; DNA, Complementary; Exons; Gene Expression Regulation, Neoplastic; Genes; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukocytes, Mononuclear; Neoplasms; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA Splicing; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1996 |
AML1a but not AML1b inhibits erythroid differentiation induced by sodium butyrate and enhances the megakaryocytic differentiation of K562 leukemia cells.
Topics: Antigens, CD; Butyrates; Butyric Acid; Cell Differentiation; Core Binding Factor Alpha 2 Subunit; DNA-Binding Proteins; Erythroblasts; Gene Expression Regulation, Neoplastic; Glycophorins; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Megakaryocytes; Proto-Oncogene Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 1997 |
Upregulation of CD9 expression during TPA treatment of K562 cells.
Topics: Antigens, CD; Cell Differentiation; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Indoles; Integrin alpha1beta1; Integrins; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Maleimides; Megakaryocytes; Membrane Glycoproteins; Platelet Glycoprotein GPIIb-IIIa Complex; Promoter Regions, Genetic; RNA, Messenger; Tetradecanoylphorbol Acetate; Tetraspanin 29; Time Factors; Tumor Cells, Cultured; Up-Regulation | 1997 |
JURL-MK1 (c-kit(high)/CD30-/CD40-) and JURL-MK2 (c-kit(low)/CD30+/CD40+) cell lines: 'two-sided' model for investigating leukemic megakaryocytopoiesis.
Topics: Antigens, Surface; CD40 Antigens; Cell Differentiation; Cells, Cultured; Chromosome Banding; Dimethyl Sulfoxide; DNA, Viral; Fusion Proteins, bcr-abl; Hematopoiesis; Herpesvirus 4, Human; Humans; Immunophenotyping; In Situ Hybridization; Karyotyping; Ki-1 Antigen; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Megakaryocytes; Middle Aged; Proto-Oncogene Proteins c-kit; Tetradecanoylphorbol Acetate; Translocation, Genetic | 1997 |
12-O-tetradecanoylphorbol-13-acetate (TPA) downregulates expression of CD30 in erythroleukemia cell line K562.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Neoplasm; Blast Crisis; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation, Leukemic; Half-Life; Humans; Ki-1 Antigen; Leukemia, Erythroblastic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Nucleic Acid Synthesis Inhibitors; Protein Kinase C; Protein Synthesis Inhibitors; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Growth arrest associated with 12-o-tetradecanoylphorbol-13-acetate-induced hematopoietic differentiation with a defective retinoblastoma tumor suppressor-mediated pathway.
Topics: Blotting, Northern; Blotting, Western; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Division; Cyclin E; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Flow Cytometry; Gene Expression; Genes, Retinoblastoma; Hematopoietic Stem Cells; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Megakaryocytes; Microtubule-Associated Proteins; Retinoblastoma Protein; RNA, Messenger; S Phase; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1998 |
Tyrosine phosphorylation of proteins in primary human myeloid leukemia cells stimulated by cytokines: analysis of the frequency of phosphorylation, and partial identification and semi-quantification of signaling molecules.
Topics: Acute Disease; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cytokines; DNA-Binding Proteins; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Interleukin-3; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Milk Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Biosynthesis; Protein-Tyrosine Kinases; Proteins; Signal Transduction; STAT5 Transcription Factor; Tetradecanoylphorbol Acetate; Thrombopoietin; Trans-Activators; Tumor Necrosis Factor-alpha | 1998 |
Latent infection and reactivation of human herpesvirus 6 in two novel myeloid cell lines.
Topics: Adult; Antigens, Viral; Blast Crisis; Cytopathogenic Effect, Viral; DNA, Viral; Hematopoietic Stem Cells; Herpesvirus 6, Human; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Neoplastic Stem Cells; Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virus Activation; Virus Latency; Virus Replication | 1999 |
CD7 expression on CD34+ cells from chronic myeloid leukaemia in chronic phase.
Topics: Adult; Antigens, CD; Antigens, CD34; Antigens, CD7; Antigens, Differentiation, Myelomonocytic; B-Lymphocytes; Blast Crisis; CD2 Antigens; Cells, Cultured; Cytokines; Female; Flow Cytometry; Hematopoietic Stem Cells; Humans; Immunomagnetic Separation; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Proto-Oncogene Proteins c-kit; Reference Values; Sialic Acid Binding Ig-like Lectin 3; Tetradecanoylphorbol Acetate | 1999 |
Restoration of Th1 cytokine synthesis by T cells of patients with chronic myelogenous leukemia in cytogenetic and hematologic remission with interferon-alpha.
Topics: Antineoplastic Agents; CD8-Positive T-Lymphocytes; Cytokines; Flow Cytometry; Humans; Interferon-alpha; Interferon-gamma; Interleukin-10; Interleukin-2; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphocyte Activation; Remission Induction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Th1 Cells; Tumor Necrosis Factor-alpha | 2000 |
Megakaryocyte maturation is associated with expression of the CXC chemokine connective tissue-activating peptide CTAP III.
Topics: Blood Coagulation Factors; Blood Platelets; Bone Marrow Cells; Cell Count; Cell Differentiation; Cell Line; Humans; Immunohistochemistry; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Megakaryocytes; Models, Biological; Peptides; Purpura, Thrombocytopenic, Idiopathic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate | 2000 |
Simultaneous flow cytometric measurement of K-562 megakaryocytic differentiation and CD56+ large granular lymphocyte cytotoxicity.
Topics: Antigens, CD; CD56 Antigen; Cell Death; Cell Differentiation; Color; Cytotoxicity Tests, Immunologic; Flow Cytometry; Humans; Integrin beta3; K562 Cells; Killer Cells, Natural; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Megakaryocytes; Platelet Membrane Glycoproteins; Tetradecanoylphorbol Acetate | 2001 |
Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters.
Topics: Animals; Base Sequence; beta-Galactosidase; Binding Sites; Brain; Cloning, Molecular; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Genomic Library; Humans; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukocytes; Luciferases; Molecular Sequence Data; Promoter Regions, Genetic; Protein Kinase C; Rats; Recombinant Fusion Proteins; Restriction Mapping; RNA Probes; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1992 |
Differentiation-induced changes in protein-tyrosine phosphatase activity and commensurate expression of CD45 in human leukemia cell lines.
Topics: Antigens, CD; Cell Differentiation; Dimethyl Sulfoxide; Electrophoresis; Histocompatibility Antigens; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Promyelocytic, Acute; Leukocyte Common Antigens; Protein Tyrosine Phosphatases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Establishment of a human leukemia subline resistant to the growth-inhibitory effect of 12-O-tetradecanoylphorbol 13-acetate (TPA) and showing non-P-glycoprotein-mediated multi-drug resistance.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carubicin; Cell Division; Cell Line; Cell Survival; Doxorubicin; Drug Resistance; Humans; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Glycoproteins; Subcellular Fractions; Tetradecanoylphorbol Acetate | 1991 |
Aphidicolin, an inhibitor of DNA replication, blocks the TPA-induced differentiation of a human megakaryoblastic cell line, MEG-O1.
Topics: Aphidicolin; Cell Differentiation; Cell Division; DNA; DNA Replication; DNA-Directed DNA Polymerase; Flow Cytometry; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Megakaryocytes; Nucleic Acid Synthesis Inhibitors; Platelet Membrane Glycoproteins; Ploidies; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Levels of p53 protein increase with maturation in human hematopoietic cells.
Topics: Acute Disease; Adult; Amino Acid Sequence; Bone Marrow; Bone Marrow Cells; Cell Division; Cell Line; Cells, Cultured; Flow Cytometry; Gene Expression; Hematopoietic Stem Cells; Humans; Immunoblotting; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Molecular Sequence Data; Oligopeptides; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 1991 |
Natural killer cell immunodeficiency in patients with chronic myelogenous leukemia. IV. Interleukin-1 deficiency, gamma-interferon deficiency and the restorative effects of short-term culture in the presence of interleukin-2 on natural killer cytotoxicity
Topics: Antigens, CD; Cells, Cultured; Cytokines; Cytotoxicity, Immunologic; Humans; Interleukin-2; Killer Cells, Natural; Killer Factors, Yeast; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphocyte Activation; Phytohemagglutinins; Proteins; Recombinant Proteins; Tetradecanoylphorbol Acetate | 1991 |
[Retinoic acid and 12-0-tetradecanoylphorbol-13-acetate (TPA) inducing bipotent differentiation of cultured primary bone marrow cells from leukemia patients].
Topics: Bone Marrow; Cell Differentiation; Drug Synergism; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Promyelocytic, Acute; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1991 |
The dyad symmetry element is the molecular target for c-fos induction and inhibition during K 562 differentiation along mutually exclusive lineages.
Topics: Base Sequence; Cell Differentiation; Cell Line; Heme; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Sequence Data; Promoter Regions, Genetic; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogenes; Restriction Mapping; Tetradecanoylphorbol Acetate | 1991 |
Induction of plasminogen activator inhibitor type 2 expression during differentiation of human K562 cells towards a macrophage phenotype.
Topics: Base Sequence; Cell Differentiation; Cholecalciferol; Dimethyl Sulfoxide; DNA Probes; Gene Expression Regulation, Neoplastic; Hematopoietic Stem Cells; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Macrophages; Molecular Sequence Data; Neoplasm Proteins; Neoplastic Stem Cells; Phenotype; Plasminogen Activators; Plasminogen Inactivators; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1990 |
Ganglioside GM3 can induce megakaryocytoid differentiation of human leukemia cell line K562 cells.
Topics: Cell Differentiation; Cell Division; G(M3) Ganglioside; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Microscopy, Electron; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Monoclonal antibodies raised against K562 cells reacted with human haematopoietic pluripotent stem cells.
Topics: Antibodies, Monoclonal; Antigen-Antibody Reactions; Antigens, Neoplasm; Antigens, Surface; Blast Crisis; Bone Marrow; Cell Differentiation; Cell Separation; Colony-Forming Units Assay; Hematopoietic Stem Cells; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Precipitin Tests; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Transcriptional regulation of c-jun gene expression by arabinofuranosylcytosine in human myeloid leukemia cells.
Topics: Actins; Blotting, Northern; Cell Cycle; Cell Differentiation; Cytarabine; Dactinomycin; DNA-Binding Proteins; Gene Expression Regulation; Humans; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 1990 |
Polyadenylic acid polymerase activity in chronic myelogenous leukemia.
Topics: Blast Crisis; Bone Marrow; Cell Line; Humans; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Nucleotidyltransferases; Polynucleotide Adenylyltransferase; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1990 |
Increased erythroid potentiating activity/tissue inhibitor of metalloproteinases and jun/fos transcription factor complex characterize tumor promoter-induced megakaryoblastic differentiation of K562 leukemia cells.
Topics: Cell Line; Cell Transformation, Neoplastic; DNA-Binding Proteins; Gene Expression; Glycoproteins; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphokines; Microbial Collagenase; Protein Biosynthesis; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinases; Transcription Factors | 1990 |
A novel CD10-positive erythroid cell line, RM10, established from a patient with chronic myelogenous leukemia.
Topics: Adult; Antigens, CD; Antigens, Differentiation; Antigens, Neoplasm; Cell Differentiation; Erythropoietin; Female; Fusion Proteins, bcr-abl; Hemoglobins; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neprilysin; Receptors, Cell Surface; Receptors, Erythropoietin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Megakaryocytic differentiation of K562 cells is associated with changes in the cytoskeletal organization and the pattern of chromatographically distinct forms of phosphotyrosyl-specific protein phosphatases.
Topics: Cell Differentiation; Cell Division; Chromatography, High Pressure Liquid; Dimethyl Sulfoxide; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Microfilament Proteins; Molecular Weight; Phosphoprotein Phosphatases; Protein Tyrosine Phosphatases; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Down-regulation of proteolytic activity in 12-O-tetradecanoyl-phorbol-13-acetate-induced K562 leukemia cell cultures: depletion of active urokinase by excess type 1 plasminogen activator inhibitor.
Topics: Cell Line; Culture Media; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Glycoproteins; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Peptide Hydrolases; Plasminogen Activators; Plasminogen Inactivators; Precipitin Tests; RNA, Messenger; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1989 |
Heterogenous response of primary cultured bone marrow cells of patients with different varieties of leukemia to differentiation inducers.
Topics: Adolescent; Adult; Aged; Bone Marrow; Child; Female; Harringtonines; Homoharringtonine; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1989 |
KU 812: a pluripotent human cell line with spontaneous erythroid terminal maturation.
Topics: Antigens, Differentiation; Biomarkers; Blood Group Antigens; Cell Differentiation; Cell Line; Colony-Stimulating Factors; Erythroblasts; Erythropoietin; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Hematopoietic Stem Cells; Hemin; Humans; Interleukin-3; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Receptors, Cell Surface; Receptors, Erythropoietin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Human neutrophil gelatinase is a component of specific granules.
Topics: Blotting, Western; Cytoplasmic Granules; Gelatinases; Humans; Immunohistochemistry; Immunosorbent Techniques; Lactoferrin; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Microscopy, Electron; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pepsin A; Peroxidase; Tetradecanoylphorbol Acetate | 1989 |
Protein kinase C deficiency in juvenile chronic myeloid leukemia: a case report.
Topics: Adult; Cell Differentiation; Child; Female; Humans; Infant; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasm Proteins; Neutrophils; Protein Kinase C; Tetradecanoylphorbol Acetate | 1989 |
Long-term culturing of TPA-induced differentiated HL-60 cells results in increased levels of lytic enzymes.
Topics: Candida albicans; Cell Differentiation; Cell Line; Chymotrypsin; Glucuronidase; Humans; Hydrolases; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Muramidase; Pancreatic Elastase; Phagocytosis; Serine Endopeptidases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Differential effects of tumor promoters on P210bcr-abl expression.
Topics: Antineoplastic Agents, Phytogenic; Cell Division; Diterpenes; Dose-Response Relationship, Drug; Fusion Proteins, bcr-abl; Gene Expression; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Terpenes; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1989 |
Effects of simultaneous and sequential exposure to granulocytic and monocytic inducers on the choice of differentiation pathway in HL-60 promyelocytic leukemia cells.
Topics: Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Drug Synergism; Granulocytes; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukocytes, Mononuclear; Tetradecanoylphorbol Acetate; Tretinoin | 1989 |
Induction of differentiation of mouse myeloid leukemia M1 cells by serum of patients with chronic myeloid leukemia.
Topics: Animals; Cell Differentiation; Culture Media; Growth Inhibitors; Humans; Interleukin-6; Leukemia Inhibitory Factor; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Leukemia, Myelomonocytic, Chronic; Lymphokines; Macrophages; Mice; Phytohemagglutinins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1988 |