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tetradecanoylphorbol acetate and Cancer of the Thymus

tetradecanoylphorbol acetate has been researched along with Cancer of the Thymus in 34 studies

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-199011 (32.35)18.7374
1990's21 (61.76)18.2507
2000's0 (0.00)29.6817
2010's2 (5.88)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fukuoka, N; Harada, M; Ito, Y; Kataoka, T; Nishida, A; Shiota, H1
Farrar, J; Hamaoka, T; Hilfiker, M; Howard, M; Johnson, B; Paul, WE; Takatsu, K1
Kirch, ME; Miller, RA; Palladino, MA; Pearlstein, KT; Pelus, LM; Staiano-Coico, L; Stutman, O1
Hiai, H; Kaneshima, H; Nishi, Y; Nishizuka, Y1
Benjamin, WR; Farrar, JJ; Steeg, PS1
Farrar, JJ; Farrar, WL; Fuller-Farrar, J; Hilfiker, ML; Simon, PL; Stadler, BM1
Anderson, WB; Cooper, HL; Kraft, AS; Sando, JJ1
Brown, BL; Corbett, NR; Dawson, CH; Dobson, PR; Dunford, JE; Varley, CL1
Mahon, TM; O'Neill, LA2
Jou, I; Kim, NK; Lee, MS; Lee, SH; Lim, IK; Park, SC; Seo, JS1
Engels, P; Gruart-Gouilleux, V; Sullivan, M1
Falk, W; Krammer, PH; Praast, G; Stoeck, M; Stricker, K; Tsukitani, Y1
Azcona-Olivera, JI; Brooks, KH; Dong, W; Linz, JE; Pestka, JJ1
Chen, D; Rothenberg, EV1
Brennan, P; Mahon, TM; O'Neill, LA1
Kidao, S; Kline, K; Sanders, BG1
Fu, KC; Horta, MF; Koizumi, H; Kwon, BS; Liu, CC; Youn, BS; Young, JD1
Dong, W; Marin, ML; Murtha, J; Pestka, JJ1
Kline, K; Sanders, BG; Yu, W1
Mahon, TM; Matthews, JS; O'Neill, LA1
Matthews, JS; O'Neill, LA1
Bickel, M; Cohen, RB; Iwai, Y; Pluznik, DH1
Bouaboula, M; Casellas, P; d'Angeac, AD; Dornand, J; Favero, J; Shire, D1
Hooton, JW; Pabst, HF; Paetkau, V; Spady, DW1
D'Angeac, AD; Dornand, J; Emonds-Alt, X; Erard, F; Garcia-Sanz, JA; Jullien, P1
Costlow, M; Essani, N; Fishman, M1
Howe, RC; MacDonald, HR; Miescher, S; Stoeck, M; von Fliedner, V1
Balls, M; Clothier, R; Lasek, W; Steer, S1
Adachi, K; Morishima, Y; Morishita, Y; Ohno, R; Saito, H; Tanimoto, M1
Dornand, J; Gerber, M; Mani, JC; Sekkat, C1
Geurts van Kessel, AH; Hagemeijer, A; Schoenmaker, E; van Dongen, JJ; van Oudenaren, A; Versnel, MA; Wolvers-Tettero, IL1
Amstad, P; Bickel, M; Evequoz, V; Mergenhagen, SE; Pluznik, DH; Tsuda, H; Wahl, SM1
Fishman, M; Gunther, G1

Other Studies

34 other study(ies) available for tetradecanoylphorbol acetate and Cancer of the Thymus

ArticleYear
Eomesodermin promotes interferon-γ expression and binds to multiple conserved noncoding sequences across the Ifng locus in mouse thymoma cell lines.
    Genes to cells : devoted to molecular & cellular mechanisms, 2016, Volume: 21, Issue:2

    Topics: Animals; Base Sequence; Cell Line, Tumor; Conserved Sequence; Humans; Interferon-gamma; Ionomycin; Mice; Promoter Regions, Genetic; T-Box Domain Proteins; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms

2016
Pillars article: Identification of a T cell-derived B cell growth factor distinct from interleukin 2. J. Exp. Med. 1982. 155: 914-923.
    Journal of immunology (Baltimore, Md. : 1950), 2013, Feb-01, Volume: 190, Issue:3

    Topics: Animals; B-Lymphocytes; Cell Line, Tumor; Culture Media, Conditioned; Female; History, 20th Century; Immunoglobulin Class Switching; Immunoglobulin Isotypes; Interleukin-2; Interleukin-4; Lymphocyte Activation; Lymphocyte Cooperation; Lymphokines; Lymphopoiesis; Mice; Mice, Inbred BALB C; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms

2013
Multiple lymphokine production by a phorbol ester-stimulated mouse thymoma: relationship to cell cycle events.
    Journal of the National Cancer Institute, 1983, Volume: 71, Issue:3

    Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Antigens, Surface; Cell Cycle; Flow Cytometry; Interferon-gamma; Lymphokines; Mice; Neoplasms, Experimental; Phenotype; Phorbols; Rats; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms

1983
Progression of mouse thymic leukemias in thymic microenvironments.
    Princess Takamatsu symposia, 1983, Volume: 14

    Topics: Animals; Cell Communication; Leukemia; Mice; Tetradecanoylphorbol Acetate; Thymus Gland; Thymus Neoplasms

1983
Production of immune interferon by an interleukin 2-independent murine T cell line.
    Proceedings of the National Academy of Sciences of the United States of America, 1982, Volume: 79, Issue:17

    Topics: Animals; Cell Line; Interferon-gamma; Interleukin-2; Kinetics; Mice; Neoplasms, Experimental; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms

1982
Thymoma production of T cell growth factor (Interleukin 2).
    Journal of immunology (Baltimore, Md. : 1950), 1980, Volume: 125, Issue:6

    Topics: Animals; Chromatography, Gel; Concanavalin A; Growth Substances; Interleukin-2; Lymphokines; Mice; Molecular Weight; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms

1980
Decrease in cytosolic calcium/phospholipid-dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells.
    The Journal of biological chemistry, 1982, Nov-25, Volume: 257, Issue:22

    Topics: Animals; Calcium; Cell Line; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Phospholipids; Protein Kinases; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms

1982
Activation of multiple protein kinases by interleukin-1.
    Annals of the New York Academy of Sciences, 1995, Sep-07, Volume: 766

    Topics: Animals; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Female; Glycogen Synthase Kinase 3; Humans; Interleukin-1; Interleukin-4; Mice; Protein Kinases; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured

1995
Studies into the effect of the tyrosine kinase inhibitor herbimycin A on NF-kappa B activation in T lymphocytes. Evidence for covalent modification of the p50 subunit.
    The Journal of biological chemistry, 1995, Dec-01, Volume: 270, Issue:48

    Topics: Animals; Base Sequence; Benzoquinones; Enzyme Inhibitors; Interleukin-1; Interleukin-2; Lactams, Macrocyclic; Lymphoma, T-Cell; Mice; Molecular Sequence Data; NF-kappa B; Oligodeoxyribonucleotides; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Quinones; Rifabutin; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Transcription Factor RelB; Transcription Factors; Tumor Cells, Cultured

1995
Differential expression of TIS21 and TIS1 genes in the various organs of Balb/c mice, thymic carcinoma tissues and human cancer cell lines.
    Journal of cancer research and clinical oncology, 1995, Volume: 121, Issue:5

    Topics: Animals; Gene Expression Regulation; Genes, Tumor Suppressor; Humans; Immediate-Early Proteins; Mice; Mice, Inbred BALB C; Neoplasms; Proteins; Tetradecanoylphorbol Acetate; Thymus Neoplasms; Tumor Cells, Cultured; Tumor Suppressor Proteins

1995
Characterization of the human interleukin-5 gene promoter: involvement of octamer binding sites in the gene promoter activity.
    European journal of immunology, 1995, Volume: 25, Issue:5

    Topics: Animals; Base Sequence; Binding Sites; Bucladesine; Calcimycin; Consensus Sequence; Gene Expression Regulation; Genes; Genes, Reporter; Humans; Interleukin-5; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmids; Point Mutation; Promoter Regions, Genetic; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Transcription Factors; Transfection; Tumor Cells, Cultured

1995
Activation of the mouse IL-2 gene by okadaic acid: synergy with interleukin-1.
    Lymphokine and cytokine research, 1994, Volume: 13, Issue:3

    Topics: Animals; Drug Synergism; Ethers, Cyclic; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Interleukin-1; Interleukin-2; Interleukin-6; Mice; Neoplasm Proteins; Okadaic Acid; Phosphoprotein Phosphatases; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured

1994
Elevated gene expression and production of interleukins 2, 4, 5, and 6 during exposure to vomitoxin (deoxynivalenol) and cycloheximide in the EL-4 thymoma.
    Toxicology and applied pharmacology, 1994, Volume: 127, Issue:2

    Topics: Clone Cells; Cycloheximide; Cytokines; Gene Expression; Interleukins; Kinetics; Leucine; Models, Biological; RNA, Messenger; Stimulation, Chemical; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Trichothecenes; Tritium; Tumor Cells, Cultured

1994
Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles.
    The Journal of experimental medicine, 1994, Mar-01, Volume: 179, Issue:3

    Topics: Base Sequence; Binding Sites; Calcimycin; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclosporine; DNA-Binding Proteins; Gene Expression; Interleukin-2; Kinetics; NF-kappa B; RNA, Messenger; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured

1994
Evidence for a redox-sensitive protein tyrosine kinase in nuclear factor kappa B activation and interleukin 2 production in EL4.NOB1 cells.
    Biochemical Society transactions, 1993, Volume: 21, Issue:4

    Topics: Alkaloids; Animals; Benzoquinones; Cell Line; Interleukin-1; Interleukin-2; Kinetics; Lactams, Macrocyclic; Mice; NF-kappa B; Oxidation-Reduction; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured

1993
RRR-alpha-tocopheryl succinate induced interleukin-2 production by avian splenic T lymphocytes and murine EL-4 thymic lymphoma cells.
    Biotechnology therapeutics, 1993, Volume: 4, Issue:1-2

    Topics: Animals; Antioxidants; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Cells, Cultured; Chickens; Chromans; Drug Synergism; Interleukin-2; Lymphoma; Mice; Spleen; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymus Gland; Thymus Neoplasms; Tocopherols; Tumor Cells, Cultured; Vitamin E

1993
Identification of a killer cell-specific regulatory element of the mouse perforin gene: an Ets-binding site-homologous motif that interacts with Ets-related proteins.
    Molecular and cellular biology, 1993, Volume: 13, Issue:11

    Topics: Animals; Base Sequence; Binding Sites; Cell Line; Chloramphenicol O-Acetyltransferase; DNA-Binding Proteins; Humans; Interleukin-2; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Leukemia, T-Cell; Lymphocyte Activation; Mast-Cell Sarcoma; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Molecular Weight; Oligodeoxyribonucleotides; Perforin; Pore Forming Cytotoxic Proteins; Proto-Oncogene Protein c-ets-1; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; Recombinant Proteins; Regulatory Sequences, Nucleic Acid; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Transcription Factors; Transfection; Tumor Cells, Cultured

1993
Investigation into the role of protein kinase C in IL1 and PMA signalling in EL4.NOB-1 thymoma cells.
    Biochemical Society transactions, 1996, Volume: 24, Issue:1

    Topics: Alkaloids; Animals; Cell Line; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Enzyme Inhibitors; Interleukin-1; Interleukin-2; Kinetics; Mice; NF-kappa B; Protein Kinase C; Recombinant Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured

1996
Effects of mycotoxins on cytokine production and proliferation in EL-4 thymoma cells.
    Journal of toxicology and environmental health, 1996, Volume: 48, Issue:4

    Topics: Androstadienes; Animals; Aspergillus; Carcinogens; Cell Survival; Fumonisins; Fusaric Acid; Fusarium; Indoles; Interleukin-2; Interleukin-5; Lymphocyte Activation; Mice; Mycotoxins; Ochratoxins; Patulin; Penicillium; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured; Wortmannin; Zearalenone; Zeranol

1996
Modulation of murine EL-4 thymic lymphoma cell proliferation and cytokine production by vitamin E succinate.
    Nutrition and cancer, 1996, Volume: 25, Issue:2

    Topics: Animals; Cell Division; Culture Media, Conditioned; Cytokines; Gene Expression; Interleukin-2; Mice; RNA, Messenger; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Tocopherols; Transforming Growth Factor beta; Tumor Cells, Cultured; Vitamin E

1996
Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells.
    The Biochemical journal, 1997, Jul-01, Volume: 325 ( Pt 1)

    Topics: Animals; Cell Membrane; Cytosol; Drug Synergism; Enzyme Inhibitors; Indoles; Interleukin-1; Interleukin-2; Isoenzymes; Kinetics; Mice; NF-kappa B; Protein Kinase C; Protein Kinase C-alpha; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Time Factors; Tumor Cells, Cultured

1997
Distinct roles for p42/p44 and p38 mitogen-activated protein kinases in the induction of IL-2 by IL-1.
    Cytokine, 1999, Volume: 11, Issue:9

    Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, Reporter; Humans; Imidazoles; Interleukin-1; Interleukin-2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Rabbits; Signal Transduction; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Transcription Factor AP-1; Transfection; Tumor Cells, Cultured

1999
Concanavalin A-induced granulocyte-macrophage colony-stimulating factor production in a murine T-cell line is posttranscriptionally controlled.
    Experimental hematology, 1992, Volume: 20, Issue:2

    Topics: Animals; Concanavalin A; Dactinomycin; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Granulocyte-Macrophage Colony-Stimulating Factor; Half-Life; Mice; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Neoplasm; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Transcription, Genetic; Tumor Cells, Cultured

1992
Contrasting effects of the protein kinase C inhibitor staurosporine on the interleukin-1 and phorbol ester activation pathways in the EL4-6.1 thymoma cell line.
    Journal of cellular physiology, 1992, Volume: 151, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Base Sequence; Cell Line; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Interleukin-1; Interleukin-2; Interleukin-4; Isoquinolines; Mice; Molecular Sequence Data; Piperazines; Polymerase Chain Reaction; Protein Kinase C; Receptors, Interleukin-2; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured

1992
Human colostrum contains an activity that inhibits the production of IL-2.
    Clinical and experimental immunology, 1991, Volume: 86, Issue:3

    Topics: Cell Survival; Colostrum; Concanavalin A; Dose-Response Relationship, Drug; Humans; Interleukin-2; Lectins; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphoma, T-Cell; Phytohemagglutinins; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Transforming Growth Factor beta

1991
Transforming growth factor type beta 1 (TGF-beta 1) down-regulates interleukin-2 production and up-regulates interleukin-2 receptor expression in a thymoma cell line.
    Journal of cellular physiology, 1991, Volume: 147, Issue:3

    Topics: Animals; Down-Regulation; Gene Expression; Interleukin-1; Interleukin-2; Mice; Receptors, Interleukin-2; RNA, Messenger; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Transforming Growth Factor beta; Up-Regulation

1991
TPA induction of EL4 resistance to macrophage-released TNF: role of ADP-ribosylation in tumoricidal activities of TNF and other factors.
    Cellular immunology, 1990, Apr-15, Volume: 127, Issue:1

    Topics: Animals; Antibodies; Benzamides; Calcimycin; Cytotoxicity, Immunologic; Cytotoxins; Down-Regulation; Genetic Variation; Macrophage Activation; Mice; Niacinamide; Pertussis Toxin; Poly(ADP-ribose) Polymerase Inhibitors; Recombinant Proteins; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Virulence Factors, Bordetella

1990
Effect of transforming growth factor beta on the EL4 thymoma variant EL4/6.1: dissociation of inhibition of proliferation from expression of IL-1 and IL-2 receptors.
    Immunobiology, 1990, Volume: 181, Issue:1

    Topics: Animals; Cell Division; Gene Expression Regulation, Neoplastic; Interleukin-1; Ionomycin; Mice; Receptors, Immunologic; Receptors, Interleukin-1; Receptors, Interleukin-2; Recombinant Proteins; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Transforming Growth Factor beta; Tumor Cells, Cultured

1990
The stimulation of EL-4 cells to produce interleukin-2 and its potential use in immunocytotoxicity testing.
    Immunopharmacology and immunotoxicology, 1989, Volume: 11, Issue:2-3

    Topics: Animals; Cell Division; Concanavalin A; Cytotoxicity Tests, Immunologic; Interleukin-2; Mice; Spleen; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate; Thymidine; Thymoma; Thymus Neoplasms; Tritium; Tumor Cells, Cultured

1989
Phorbol ester induces interleukin-2 receptor on the cell surface of precursor thymocyte leukemia with no rearrangement of T cell receptor beta and gamma genes.
    Blood, 1987, Volume: 70, Issue:5

    Topics: Antibodies, Monoclonal; Cell Division; Cell Membrane; Cells, Cultured; Child; DNA Restriction Enzymes; Genes; Humans; Interleukin-2; Kinetics; Male; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Antigen, T-Cell; Receptors, Immunologic; Receptors, Interleukin-2; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms

1987
Lipoxygenase inhibitors suppress IL-2 synthesis: relationship with rise of [Ca++]i and the events dependent on protein kinase C activation.
    Immunology letters, 1987, Volume: 16, Issue:2

    Topics: Animals; Butylated Hydroxyanisole; Calcimycin; Calcium; Cell Line; Enzyme Activation; Humans; Interleukin-2; Kinetics; Lipoxygenase Inhibitors; Masoprocol; Mice; Phenols; Protein Kinase C; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms

1987
Construction of human-mouse T cell hybrids that express human T cell-associated surface antigens and allow the chromosomal localization of these antigens.
    Journal of immunology (Baltimore, Md. : 1950), 1986, Aug-01, Volume: 137, Issue:3

    Topics: Adult; Animals; Antigens, Surface; Cell Fusion; Cell Line; Child, Preschool; Chromosome Banding; Chromosomes, Human; Humans; Hybridomas; Leukemia, Lymphoid; Lymphocyte Activation; Male; Mice; Species Specificity; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms

1986
Differential regulation of colony-stimulating factors and interleukin 2 production by cyclosporin A.
    Proceedings of the National Academy of Sciences of the United States of America, 1987, Volume: 84, Issue:10

    Topics: Animals; Colony-Stimulating Factors; Cyclosporins; Female; Interleukin-2; Kinetics; Mice; Mice, Inbred CBA; Spleen; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms

1987
Induction of tumor cell resistance to macrophage-mediated lysis by phorbol esters: a postbinding event.
    Cellular immunology, 1986, Volume: 100, Issue:2

    Topics: Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Line; Cytotoxicity, Immunologic; Lymphoma; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Phorbol Esters; Protein Kinase C; Rats; Rats, Inbred WF; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms

1986