tetradecanoylphorbol acetate has been researched along with Cancer of Prostate in 98 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (3.06) | 18.7374 |
| 1990's | 24 (24.49) | 18.2507 |
| 2000's | 55 (56.12) | 29.6817 |
| 2010's | 15 (15.31) | 24.3611 |
| 2020's | 1 (1.02) | 2.80 |
| Authors | Studies |
|---|---|
| Flippen-Anderson, J; Fujii, T; Kazanietz, MG; Kozikowski, AP; Qiao, L; Rauser, L; Rong, SB; Roth, BL; Savage, J; Wang, S; Wu, XW; Zhao, LY | 1 |
| Blumberg, PM; Comin, MJ; Donadío, LG; Esch, TE; Garcia, LC; Hill, CS; Jelinek, R; Kedei, N; Kelley, JA; Kelsey, JS; Kolusheva, S; Lewin, NE; Mann, E; Marquez, VE; Peach, ML; Santos, M; Yang, J | 1 |
| Kohno, S; Kumar, S; Linn, P; Nagatani, N; Soga, T; Takahashi, C; Watanabe, Y | 1 |
| Haidari, M; Wakame, K; Zhang, W | 1 |
| Dejima, T; Inokuchi, J; Itsumi, M; Kashiwagi, E; Naito, S; Shiota, M; Takeuchi, A; Tatsugami, K; Uchiumi, T; Yokomizo, A | 1 |
| Hou, YC; Li, CC; Yeh, CL; Yeh, SL | 1 |
| Berry, P; Maitland, NJ; Noble, A; Otsuka, M; Rumsby, MG; Schmitt, J | 1 |
| Chang, WY; Choi, YH; Hyun, JW; Jayasooriya, RG; Kim, GY; Park, SR | 1 |
| Bane, KL; Corum, SL; Danielpour, D; Kao, HY; Shankar, E; Song, K; Wang, H | 1 |
| Caino, MC; Kazanietz, MG; Oliva, JL; von Burstin, VA; Xiao, L | 1 |
| Gonzalez-Guerrico, A; Kazanietz, MG; Xiao, L | 1 |
| Arnoldussen, YJ; Danielsen, HE; Lorenzo, PI; Maelandsmo, GM; Pretorius, ME; Risberg, B; Saatcioglu, F; Waehre, H | 1 |
| Fuks, Z; Haimovitz-Friedman, A; Kang, JH; Kolesnick, R; Lerman, G; Marquez, VE; Rotenberg, SA; Truman, JP | 1 |
| Eto, M; Kazanietz, MG; Xiao, L | 1 |
| Bao, BY; Hsu, JW; Lee, YF; Messing, E; Ting, HJ; Yasmin-Karim, S | 1 |
| Chung, LW; Davidson, AJ; He, D; He, H; Marshall, FF; Wang, R; Wu, D; Zhau, HE | 1 |
| Kazanietz, MG; von Burstin, VA; Xiao, L | 1 |
| Caino, MC; Griner, E; Kazanietz, MG; Meshki, J; von Burstin, VA | 1 |
| Maitland, N; Rodrigues, G; Rumsby, M; Schmitt, J; Sharrard, M; Stower, M | 1 |
| Blumberg, PM; Chen, J; Czap, A; Czifra, G; Garfield, SH; Goldsmith, PK; Keck, GE; Kedei, N; Kraft, MB; Li, W; Lim, L; Lubart, ES; Mannan, P; Morrison, T; Telek, A; Yang, D | 1 |
| Ferreira, J; Ortega, A; Parra, E | 1 |
| Chen, J; Giridhar, KV; Wang, QJ; Xu, S; Zhang, L | 1 |
| Burchardt, M; Buttyan, R; Chen, MW; Chopin, DK; De La Taille, A; Friedman, RA; Gil-Diez-De-Medina, S; Shen, R; Vacherot, F | 1 |
| Satoh, K; Shimizu, T; Sugibayashi, R; Suzuki, T; Takeda, K | 1 |
| Belldegrun, A; Bonavida, B; Caliliw, R; Frost, P | 1 |
| Fujii, T; Gavrielides, MV; Kazanietz, MG; Mitsuuchi, Y; Tanaka, Y | 1 |
| Sato, K; Shimizu, T; Suzuki, T; Tachibana, K; Takeda, K | 1 |
| Foreman, TL; Gregory, CW; Harris Ford, O; McJilton, MA; Mohler, JL; Morgan Lasater, A; Terrian, DM; Van Sikes, C; Weidner, DA; Wescott, GG; Wu, D | 1 |
| Altuwaijri, S; Chang, C; Chuang, KH; Hanchett, LA; Kang, HY; Lin, HK; Lin, WJ; Rahman, MM; Tsai, MY; Yang, L; Yeh, S; Zhang, Y | 1 |
| Avila, GE; Chang, RL; Conney, AH; Cui, XX; Lee, S; Lin, Y; Lou, YR; Lu, YP; Newmark, H; Rabson, A; Reuhl, K; Shih, WJ; Zheng, X | 1 |
| Chen, C; Dong, JT; Otto, KB; Sun, X; Uht, RM; Zhou, Y; Zhou, Z | 1 |
| Ikezoe, T; Koeffler, HP; Taguchi, H; Yang, Y | 1 |
| Blok, LJ; Grootegoed, JA; Penninkhof, F | 1 |
| Bennani-Baiti, N; Powell, CT; Yin, L | 1 |
| Eling, TE; Shim, M | 1 |
| O'Brian, CA; Stewart, JR | 1 |
| Avila, GE; Chang, RL; Conney, AH; Crowell, P; Cui, XX; Hansson, A; Lin, Y; Lou, YR; Lu, YP; Rabson, AB; Ryan, AD; Shih, WJ; Suh, J; Zheng, X | 1 |
| Nanus, DM; Shen, R; Sumitomo, M | 1 |
| Gonzalez-Guerrico, AM; Kazanietz, MG | 1 |
| Powell, CT; Yin, L | 1 |
| De Servi, B; Hermani, A; Mayer, D; Medunjanin, S; Tessier, PA | 1 |
| Costello, LC; Franklin, RB; Yu, Z; Zou, J | 1 |
| Avila, GE; Chang, RL; Conney, AH; Cui, XX; Garzotto, M; Hebbar, V; Kong, AN; Lin, Y; Lu, SE; Rabson, AB; Shih, WJ; Zheng, X | 1 |
| Hsiang, CH; Ornstein, DK; Tunoda, T; Tyson, DR; Whang, YE | 1 |
| Li, W; Olumi, AF; Zhang, X | 1 |
| Avila, G; Chang, RL; Conney, AH; Cui, XX; Huang, MT; Kong, AN; Liu, Y; Rabson, AB; Zheng, X | 1 |
| Hong, JT; Jung, JK; Lee, BS; Lee, SY; Moon, DC; Song, HS; Yoon, DY; Yuk, DY | 1 |
| Lorenzo, PI; Saatcioglu, F | 1 |
| Kaighn, ME; Lechner, JF | 1 |
| Franzén, P; Ichijo, H; Miyazono, K | 1 |
| Murtha, PE; Young, CY; Zhang, J | 1 |
| An, S; Chen, Y; Mallouh, C; Schneidau, TA; Tazaki, H; Wang, XH; Whyzmuzis, CA; Wu, JM | 1 |
| Day, ML; Humphrey, PA; Swanson, PE; Wu, S; Zhao, X | 1 |
| Bai, G; Krongrad, A | 1 |
| Carbone, PP; Carey, P; Gilmore, D; Love, RR; Pomplun, M; Tutsch, KD; Verma, AK; Wilding, G | 1 |
| Hrzenjak, M; Shain, SA | 2 |
| Blagosklonny, MV; Neckers, LM; Nguyen, P; Schulte, T; Trepel, J | 1 |
| Blagosklonny, MV; El-Deiry, WS; Prabhu, NS | 1 |
| Brittis, NJ; Fair, WR; Heston, WD; Hug, H; Powell, CT; Stec, D | 1 |
| Bowden, GT; Koster, JJ; Nagle, RB; Sundareshan, P | 1 |
| Bruchovsky, N; Gleave, ME; Lange, PH; Rennie, PS; Saatcioglu, F; Sadar, MD; Sato, N; Sato, S | 1 |
| Buttyan, R; Dorai, T; Katz, AE; Olsson, CA | 1 |
| Bernhard, EJ; Hua, J; Muschel, RJ; Sehgal, G; Sehgal, I; Thompson, TC | 1 |
| Henttu, P; Vihko, P | 1 |
| Chiu, IM; Chotani, MA; Payson, RA | 1 |
| Hu, Y; Shima, I; Stearns, ME; Wang, M | 1 |
| El-Deiry, WS; Mitchell, KO | 1 |
| Lu, S; Tsai, MJ; Tsai, SY | 1 |
| Cardon-Cardo, C; Fuks, Z; Garzotto, M; Haimovitz-Friedman, A; Heston, WD; Huryk, R; Kolesnick, R; Liao, WC; White-Jones, M | 1 |
| Ely, BD; Hsieh, JT; Pong, RC; Tseng, CP; Wang, Z; Zhou, J | 1 |
| Becker, M; Cato, AC; Klocker, H; Mink, S; Peterziel, H; Schonert, A | 1 |
| Costello, LC; Franklin, RB; Liu, Y; Zou, J | 1 |
| Bernabó, JL; Caamaño, J; Fujii, T; García-Bermejo, ML; Kazanietz, MG; Kuroki, T; Li, L; Ohba, M; Yuspa, SH | 1 |
| Chiles, K; Feldser, D; Georgescu, MM; Hanrahan, C; Laughner, E; Semenza, GL; Simons, JW; Zhong, H | 1 |
| Akita, H; Hashimoto, Y; Iizuka, A; Ikeda, K; Kohri, K; Nakanishi, M | 1 |
| Awad, AB; Fink, CS; Gan, Y | 1 |
| Fair, WR; Gschwend, JE; Powell, CT | 1 |
| Dean, J; Lin, FF; Lin, MF; Madhavan, D; Zelivianski, S | 1 |
| Alcover, J; Ballesta, AM; Beardo, P; Filella, X; Molina, R; Zarco, MA | 1 |
| Gotoh, A; Keller, ET; Matsumoto, T; Mizokami, A; Yamada, H | 1 |
| Garcia-Arenas, R; Lee, MS; Lin, FF; Lin, MF | 1 |
| Dai, J; Goldberg, JS; Nanus, DM; Navarro, D; Shen, R; Sumitomo, M | 1 |
| Blagosklonny, MV; Dixon, SC; Figg, WD; Robey, R | 1 |
| Hisatake , J; Koeffler, HP; O'Kelly, J; Tomoyasu, S; Uskokovic, MR | 1 |
| Hamada, H; Shimizu, T; Sugibayashi, R; Suzuki, T; Takeda, K; Yamamoto, N | 1 |
| Day, ML; Zhao, X | 1 |
| Hanrahan, C; Simons, JW; van der Poel, H; Zhong, H | 1 |
| Blumberg, PM; Fujii, T; Garcia-Bermejo, ML; Han, KC; Kazanietz, MG; Kuroki, T; Lee, J; Leskow, FC; Marquez, VE; Ohba, M; Wang, Q | 1 |
| He, C; Li, H; Zheng, J | 1 |
| Engedal, N; Korkmaz, CG; Saatcioglu, F | 1 |
| Chen, CD; Sawyers, CL | 1 |
| Dean, J; Lin, FF; Lin, MF; Zhang, XQ | 1 |
| Bailey, KJ; Kassis, J; Solava, J; Souto, JC; Turner, T; Wells, A | 1 |
| Aaronson, D; Catling, AD; Christian, RE; Ficarro, SB; Gioeli, D; Hancock, M; Hunt, DF; Kwiek, JJ; Settlage, RE; Shabanowitz, J; Weber, MJ; White, FM | 1 |
| Andrews, PE; Montgomery, BT; Tindall, DJ; Young, CY | 1 |
| Attramadal, A; Gautvik, KM; Gordeladze, JO; Purvis, K; Rur, H; Tveter, K | 1 |
| Blumberg, PM; Kochenburger, RJ; Little, JB; Lovett, DR; Nagasawa, H; Schmit, A; Weichselbaum, RR | 1 |
1 review(s) available for tetradecanoylphorbol acetate and Cancer of Prostate
| Article | Year |
|---|---|
Involvement of neutral endopeptidase in neoplastic progression.
Topics: Apoptosis; Cell Movement; CSK Tyrosine-Protein Kinase; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; Hyaluronan Receptors; Male; Neoplasm Invasiveness; Neprilysin; Neurofibromin 2; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; src-Family Kinases; Tetradecanoylphorbol Acetate; Tumor Suppressor Proteins | 2005 |
1 trial(s) available for tetradecanoylphorbol acetate and Cancer of Prostate
| Article | Year |
|---|---|
Randomized phase I chemoprevention dose-seeking study of alpha-difluoromethylornithine.
Topics: Adult; Carcinoma; Colonic Neoplasms; Eflornithine; Enzyme Induction; Female; Humans; Male; Ornithine Decarboxylase; Prostatic Neoplasms; Skin; Tetradecanoylphorbol Acetate; Urinary Bladder Neoplasms | 1993 |
96 other study(ies) available for tetradecanoylphorbol acetate and Cancer of Prostate
| Article | Year |
|---|---|
Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogues as potential inhibitors of prostate cancer cell growth.
Topics: Antineoplastic Agents; Apoptosis; Dose-Response Relationship, Drug; Drug Design; Enzyme Activators; Humans; Isoenzymes; Male; Prostate; Prostatic Neoplasms; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Pyrrolidinones; Stereoisomerism; Tumor Cells, Cultured | 2001 |
Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP.
Topics: Animals; Cell Membrane; Cells, Cultured; CHO Cells; Cricetulus; Diglycerides; DNA-Binding Proteins; Fluorescence Polarization; Fluorescence Resonance Energy Transfer; Guanine Nucleotide Exchange Factors; HEK293 Cells; Humans; Indoles; Lactones; Male; Models, Molecular; Prostatic Neoplasms; Protein Isoforms; Protein Kinase C | 2014 |
Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion.
Topics: Animals; Apoptosis; Benzoquinones; Cell Line, Tumor; Gene Deletion; HEK293 Cells; Humans; Male; Mice, Knockout; Mice, Nude; Mice, SCID; PC-3 Cells; Prostatic Neoplasms; Retinoblastoma Protein; Succinate-CoA Ligases; Tetradecanoylphorbol Acetate | 2020 |
Disruption of endothelial adherens junction by invasive breast cancer cells is mediated by reactive oxygen species and is attenuated by AHCC.
Topics: Acetylcysteine; Adherens Junctions; Antigens, CD; Antineoplastic Agents, Phytogenic; Antioxidants; beta Catenin; Breast Neoplasms; Cadherins; Cell Movement; Endothelial Cells; Endothelium, Vascular; Female; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen Peroxide; Male; Ovarian Neoplasms; Plant Extracts; Prostatic Neoplasms; Reactive Oxygen Species; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 2013 |
PMA induces androgen receptor downregulation and cellular apoptosis in prostate cancer cells.
Topics: Androgen Receptor Antagonists; Antineoplastic Agents; Apoptosis; Benzamides; Cell Line, Tumor; Down-Regulation; Drug Resistance, Neoplasm; E2F1 Transcription Factor; Gene Knockdown Techniques; Humans; Male; MAP Kinase Signaling System; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Protein Kinase C; Receptors, Androgen; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2014 |
Effects of eicosapentaenoic acid and docosahexaenoic acid on prostate cancer cell migration and invasion induced by tumor-associated macrophages.
Topics: Cell Movement; Cell Survival; Coculture Techniques; Culture Media, Conditioned; Docosahexaenoic Acids; Eicosapentaenoic Acid; Humans; Macrophage Activation; Macrophages; Male; Neoplasm Invasiveness; Prostatic Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2014 |
Phorbol ester stimulates ethanolamine release from the metastatic basal prostate cancer cell line PC3 but not from prostate epithelial cell lines LNCaP and P4E6.
Topics: Cell Line; Cell Line, Tumor; Enzyme Activation; Epithelial Cells; Ethanolamine; Humans; Intercellular Signaling Peptides and Proteins; Male; Neoplasm Metastasis; Peptides; Phospholipase D; Prostate; Prostatic Neoplasms; Tetradecanoylphorbol Acetate; Wasp Venoms | 2014 |
Camptothecin suppresses expression of matrix metalloproteinase-9 and vascular endothelial growth factor in DU145 cells through PI3K/Akt-mediated inhibition of NF-κB activity and Nrf2-dependent induction of HO-1 expression.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Heme Oxygenase-1; Humans; Male; Matrix Metalloproteinase 9; NF-kappa B; Phosphatidylinositol 3-Kinases; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Signal Transduction; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A | 2015 |
A Signaling Network Controlling Androgenic Repression of c-Fos Protein in Prostate Adenocarcinoma Cells.
Topics: Adenocarcinoma; Androgens; Cell Death; Cell Line, Tumor; Dihydrotestosterone; Down-Regulation; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Signaling System; Metribolone; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Prostate; Prostatic Neoplasms; Protein Kinase C; Proto-Oncogene Proteins c-fos; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate | 2016 |
Phorbol ester-induced apoptosis and senescence in cancer cell models.
Topics: Adenoviridae; Apoptosis; Cell Cycle; Cell Line, Tumor; Cellular Senescence; Humans; Male; Prostatic Neoplasms; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-epsilon; RNA Interference; Tetradecanoylphorbol Acetate | 2008 |
PKC-mediated secretion of death factors in LNCaP prostate cancer cells is regulated by androgens.
Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Culture Media, Conditioned; Enzyme-Linked Immunosorbent Assay; Humans; JNK Mitogen-Activated Protein Kinases; Male; Metribolone; p38 Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Protein Kinase C-delta; Receptors, Androgen; RNA, Neoplasm; RNA, Small Interfering; Signal Transduction; Tetradecanoylphorbol Acetate; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha | 2009 |
The mitogen-activated protein kinase phosphatase vaccinia H1-related protein inhibits apoptosis in prostate cancer cells and is overexpressed in prostate cancer.
Topics: Androgens; Apoptosis; Cell Line, Tumor; Dual Specificity Phosphatase 1; Dual Specificity Phosphatase 3; Humans; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Metribolone; Phosphorylation; Prostatic Neoplasms; RNA, Messenger; Tetradecanoylphorbol Acetate; Thapsigargin | 2008 |
PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo.
Topics: 4-Butyrolactone; Androgens; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; DNA-Binding Proteins; Down-Regulation; Enzyme Activation; Humans; Kinetics; Male; Prostatic Neoplasms; Protein Kinase C-alpha; Protein Serine-Threonine Kinases; Tetradecanoylphorbol Acetate; Tumor Suppressor Proteins; Valerates | 2009 |
ROCK mediates phorbol ester-induced apoptosis in prostate cancer cells via p21Cip1 up-regulation and JNK.
Topics: Amides; Apoptosis; Carcinogens; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Cytoskeleton; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Kinase 4; Prostatic Neoplasms; Protein Kinase C-delta; Pyridines; Response Elements; rho-Associated Kinases; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Suppressor Protein p53; Up-Regulation | 2009 |
Down-regulation of NF-kappaB signals is involved in loss of 1alpha,25-dihydroxyvitamin D3 responsiveness.
Topics: Cell Line, Tumor; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasm Proteins; NF-kappa B; Prostatic Neoplasms; Receptors, Calcitriol; Signal Transduction; Tetradecanoylphorbol Acetate; Vitamin D | 2010 |
Phorbol ester phorbol-12-myristate-13-acetate induces epithelial to mesenchymal transition in human prostate cancer ARCaPE cells.
Topics: Blotting, Western; Carcinogens; Cell Line, Tumor; Cell Movement; Epithelial Cells; Humans; Indoles; Isoenzymes; Male; Maleimides; Mesoderm; Microscopy, Phase-Contrast; Prostatic Neoplasms; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction; Stromal Cells; Tetradecanoylphorbol Acetate | 2010 |
Bryostatin 1 inhibits phorbol ester-induced apoptosis in prostate cancer cells by differentially modulating protein kinase C (PKC) delta translocation and preventing PKCdelta-mediated release of tumor necrosis factor-alpha.
Topics: Antineoplastic Agents; Apoptosis; Bryostatins; Humans; Isoenzymes; Lactones; Male; Phorbol Esters; Prostatic Neoplasms; Protein Kinase C; Protein Kinase C-delta; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2010 |
Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway.
Topics: Apoptosis; bcl-Associated Death Protein; Cell Line, Tumor; Cell Survival; Humans; JNK Mitogen-Activated Protein Kinases; Male; Phosphorylation; Prostatic Neoplasms; Protein Kinase C-epsilon; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2010 |
Human prostate cell lines from normal and tumourigenic epithelia differ in the pattern and control of choline lipid headgroups released into the medium on stimulation of protein kinase C.
Topics: Cell Line, Tumor; Choline; Culture Media; Epithelium; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Isoenzymes; Lipid Metabolism; Male; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Neoplasms, Glandular and Epithelial; Phosphorylation; Phosphorylcholine; Prostate; Prostatic Neoplasms; Protein Kinase C-alpha; Tetradecanoylphorbol Acetate | 2011 |
The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line.
Topics: Apoptosis; Bryostatins; Cell Division; Cell Line, Tumor; Down-Regulation; Humans; Male; Phosphorylation; Prostatic Neoplasms; Protein Kinase C; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; U937 Cells | 2011 |
Overexpression of EGR-1 modulates the activity of NF-κB and AP-1 in prostate carcinoma PC-3 and LNCaP cell lines.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cisplatin; Early Growth Response Protein 1; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Intracellular Space; Male; NF-kappa B; Prostatic Neoplasms; Protein Transport; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2011 |
A protein kinase C/protein kinase D pathway protects LNCaP prostate cancer cells from phorbol ester-induced apoptosis by promoting ERK1/2 and NF-{kappa}B activities.
Topics: Apoptosis; Blotting, Western; Carcinogens; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Luciferases; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasms, Hormone-Dependent; NF-kappa B; Prostatic Neoplasms; Protein Kinase C; RNA, Small Interfering; Signal Transduction; Tetradecanoylphorbol Acetate | 2011 |
The emergence of protocadherin-PC expression during the acquisition of apoptosis-resistance by prostate cancer cells.
Topics: Adenocarcinoma; Amino Acid Sequence; Androgens; Animals; Apoptosis; Base Sequence; Cadherins; Cloning, Molecular; Culture Media, Serum-Free; Cytoplasm; DNA, Complementary; Drug Resistance; Gene Amplification; Gene Expression Regulation, Neoplastic; Genes; Humans; Male; Mice; Mice, Nude; Molecular Sequence Data; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Open Reading Frames; Peptides; Phenotype; Prostatic Neoplasms; Protein Biosynthesis; Protein Sorting Signals; Protocadherins; Subtraction Technique; Tetradecanoylphorbol Acetate | 2002 |
Differential expression of genes during TPA-induced differentiation of human prostatic cancer TSU-Pr1 cells.
Topics: Antineoplastic Agents; Blotting, Northern; Cell Differentiation; Gene Expression Profiling; Humans; Male; Prostatic Neoplasms; Tetradecanoylphorbol Acetate | 2002 |
Immunosensitization of resistant human tumor cells to cytotoxicity by tumor infiltrating lymphocytes.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Carcinoma; Carcinoma, Renal Cell; Cisplatin; Combined Modality Therapy; Cytotoxicity, Immunologic; Drug Resistance, Neoplasm; Egtazic Acid; Fas Ligand Protein; fas Receptor; Female; Humans; Interleukin-2; Ionomycin; Kidney Neoplasms; Killer Cells, Lymphokine-Activated; Lymphocytes, Tumor-Infiltrating; Magnesium Chloride; Male; Membrane Glycoproteins; Ovarian Neoplasms; Perforin; Pore Forming Cytotoxic Proteins; Prostatic Neoplasms; Recombinant Proteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2003 |
Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway.
Topics: Androstadienes; Apoptosis; Blotting, Western; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Humans; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Prostatic Neoplasms; Protein Isoforms; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; RNA Interference; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Tumor Cells, Cultured; Wortmannin | 2003 |
Induction of plasminogen activator inhibitor-2 is associated with suppression of invasive activity in TPA-mediated differentiation of human prostate cancer cells.
Topics: Cell Differentiation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasm Invasiveness; Plasminogen Activator Inhibitor 2; Prostatic Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2003 |
Protein kinase Cepsilon interacts with Bax and promotes survival of human prostate cancer cells.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Survival; Cytochrome c Group; Electrophoresis, Gel, Two-Dimensional; Epithelial Cells; Humans; Male; Mitochondria; Oligonucleotides, Antisense; Prostatic Neoplasms; Protein Kinase C; Protein Kinase C-epsilon; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Tetradecanoylphorbol Acetate; Transplantation, Heterologous; Tumor Cells, Cultured | 2003 |
Interruption of nuclear factor kappaB signaling by the androgen receptor facilitates 12-O-tetradecanoylphorbolacetate-induced apoptosis in androgen-sensitive prostate cancer LNCaP cells.
Topics: Androgens; Apoptosis; Caspase 3; Caspases; Cell Line, Tumor; Dihydrotestosterone; Enzyme Activation; Humans; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; Neoplasms, Hormone-Dependent; NF-kappa B; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor RelA; Transfection | 2003 |
Inhibitory effect of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans-retinoic acid on the growth of LNCaP prostate tumors in immunodeficient mice.
Topics: Animals; Apoptosis; Cell Division; Cell Line, Tumor; Drug Therapy, Combination; Male; Mice; Prostatic Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 2004 |
Regulation of KLF5 involves the Sp1 transcription factor in human epithelial cells.
Topics: Angiotensin II; Animals; Base Sequence; Binding Sites; Cell Line, Tumor; Cloning, Molecular; Conserved Sequence; DNA-Binding Proteins; Early Growth Response Protein 1; Electrophoretic Mobility Shift Assay; Epidermal Growth Factor; Epithelial Cells; Fibroblast Growth Factor 2; Gene Expression; HeLa Cells; Humans; Immediate-Early Proteins; Kruppel-Like Transcription Factors; Luciferases; Male; Metribolone; Mice; Molecular Sequence Data; Oligonucleotides; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Binding; Rats; Recombinant Fusion Proteins; Rodentia; Sequence Deletion; Sequence Homology, Nucleic Acid; Sp1 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription Factors; Transfection; Tretinoin; Tumor Necrosis Factor-alpha | 2004 |
JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA).
Topics: Adaptor Proteins, Signal Transducing; Androgens; Apoptosis; Blotting, Western; Carcinogens; Carrier Proteins; Cell Division; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Humans; Male; Plasmids; Prostate-Specific Antigen; Prostatic Neoplasms; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Up-Regulation | 2004 |
Identification of REPS2 as a putative modulator of NF-kappaB activity in prostate cancer cells.
Topics: Animals; Calcium-Binding Proteins; Chlorocebus aethiops; COS Cells; Humans; Intracellular Signaling Peptides and Proteins; Male; NF-kappa B; Prostatic Neoplasms; Proteins; Tetradecanoylphorbol Acetate; Transcription Factor RelA; Tryptophan | 2004 |
Phorbol ester-induced apoptosis of C4-2 cells requires both a unique and a redundant protein kinase C signaling pathway.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; DNA Fragmentation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; Isoenzymes; Male; Phosphorylation; Prostatic Neoplasms; Protein Kinase C; Retinoblastoma Protein; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate | 2005 |
Protein kinase C-dependent regulation of NAG-1/placental bone morphogenic protein/MIC-1 expression in LNCaP prostate carcinoma cells.
Topics: Apoptosis; Blotting, Northern; Blotting, Western; Carcinogens; Cell Line, Tumor; Cell Nucleus; Cell Survival; Chromatin Immunoprecipitation; Cytokines; Dose-Response Relationship, Drug; Gene Expression Regulation; Growth Differentiation Factor 15; Humans; Inflammation; JNK Mitogen-Activated Protein Kinases; Luciferases; Male; MAP Kinase Kinase 4; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Isoforms; Protein Kinase C; RNA, Messenger; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic; Transfection | 2005 |
Protein kinase C-{alpha} mediates epidermal growth factor receptor transactivation in human prostate cancer cells.
Topics: Enzyme Activation; ErbB Receptors; Humans; Male; Mitogen-Activated Protein Kinases; Neoplasms, Hormone-Dependent; Phosphorylation; Prostatic Neoplasms; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase Inhibitors; ras Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcriptional Activation; Tumor Cells, Cultured | 2005 |
Inhibitory effects of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans retinoic acid on the growth of cultured human pancreas cancer cells and pancreas tumor xenografts in immunodeficient mice.
Topics: Animals; Apoptosis; Body Weight; Cell Cycle; Cell Proliferation; Humans; Immunohistochemistry; Male; Mice; Neoplasm Transplantation; Paclitaxel; Pancreatic Neoplasms; Phosphorylation; Prostatic Neoplasms; Protein Kinase C; Retinoblastoma Protein; Sulindac; Tetradecanoylphorbol Acetate; Transplantation, Heterologous; Tretinoin; Tumor Cells, Cultured | 2005 |
Phorbol ester-induced apoptosis in prostate cancer cells via autocrine activation of the extrinsic apoptotic cascade: a key role for protein kinase C delta.
Topics: Antibodies, Monoclonal; Apoptosis; Apoptosis Regulatory Proteins; Base Sequence; Cell Line, Tumor; Enzyme Activation; Humans; Male; MAP Kinase Signaling System; Membrane Glycoproteins; Prostatic Neoplasms; Protein Kinase C-delta; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; RNA Interference; RNA, Neoplasm; Tetradecanoylphorbol Acetate; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha | 2005 |
Overexpression of PKCepsilon sensitizes LNCaP human prostate cancer cells to induction of apoptosis by bryostatin 1.
Topics: Antineoplastic Agents; Apoptosis; Bryostatins; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dihydrotestosterone; Dose-Response Relationship, Drug; Humans; Immunoblotting; Macrolides; Male; Phosphorylation; Prostatic Neoplasms; Protein Kinase C-epsilon; Retinoblastoma Protein; Tetradecanoylphorbol Acetate; Transfection | 2006 |
S100A8 and S100A9 activate MAP kinase and NF-kappaB signaling pathways and trigger translocation of RAGE in human prostate cancer cells.
Topics: Calcium; Calgranulin A; Calgranulin B; Cell Line, Tumor; Cell Movement; Cytosol; Enzyme Activation; Gene Expression Regulation; Humans; Male; MAP Kinase Signaling System; Molecular Sequence Data; NF-kappa B; Phosphorylation; Prostatic Neoplasms; Protein Transport; Receptor for Advanced Glycation End Products; Signal Transduction; Tetradecanoylphorbol Acetate | 2006 |
EAAC1 is expressed in rat and human prostate epithelial cells; functions as a high-affinity L-aspartate transporter; and is regulated by prolactin and testosterone.
Topics: Animals; Aspartic Acid; Biological Transport; Brain Chemistry; Cell Line, Tumor; Cells, Cultured; Citric Acid; Epithelial Cells; Excitatory Amino Acid Transporter 3; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasm Proteins; Nerve Tissue Proteins; Prolactin; Prostate; Prostatic Neoplasms; Rats; Testosterone; Tetradecanoylphorbol Acetate | 2006 |
Effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) in combination with paclitaxel (Taxol) on prostate Cancer LNCaP cells cultured in vitro or grown as xenograft tumors in immunodeficient mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Screening Assays, Antitumor; Humans; Injections, Intraperitoneal; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Nude; Mice, SCID; Paclitaxel; Phosphorylation; Prostatic Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Treatment Outcome; Xenograft Model Antitumor Assays | 2006 |
The impact of altered annexin I protein levels on apoptosis and signal transduction pathways in prostate cancer cells.
Topics: Annexin A1; Apoptosis; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Progression; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Signal Transduction; Tetradecanoylphorbol Acetate | 2006 |
Low-dose 12-O-tetradecanoylphorbol-13-acetate enhances tumor necrosis factor related apoptosis-inducing ligand induced apoptosis in prostate cancer cells.
Topics: Androgens; Animals; Antibodies, Monoclonal; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Humans; Male; Mice; Mice, Nude; Neoplasms, Hormone-Dependent; Phenotype; Prostatic Neoplasms; Recombinant Proteins; Tetradecanoylphorbol Acetate; TNF-Related Apoptosis-Inducing Ligand; Transcription Factor AP-1; Up-Regulation | 2007 |
Inhibition of NF-kappaB by (E)3-[(4-methylphenyl)-sulfonyl]-2-propenenitrile (BAY11-7082; BAY) is associated with enhanced 12-O-tetradecanoylphorbol-13-acetate-induced growth suppression and apoptosis in human prostate cancer PC-3 cells.
Topics: Animals; Apoptosis; Cell Proliferation; Humans; Male; Mice; Mice, Nude; NF-kappa B; Nitriles; Prostatic Neoplasms; Sulfones; Tetradecanoylphorbol Acetate | 2008 |
Growth inhibitory effects of obovatol through induction of apoptotic cell death in prostate and colon cancer by blocking of NF-kappaB.
Topics: Apoptosis; Biphenyl Compounds; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Humans; Male; NF-kappa B; Phenyl Ethers; Phosphorylation; Prostatic Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2008 |
Inhibition of apoptosis in prostate cancer cells by androgens is mediated through downregulation of c-Jun N-terminal kinase activation.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Anilides; Apoptosis; Down-Regulation; Enzyme Activation; Humans; In Situ Nick-End Labeling; JNK Mitogen-Activated Protein Kinases; Male; Microscopy, Fluorescence; Neoplasms, Hormone-Dependent; Nitriles; Prostatic Neoplasms; Receptors, Androgen; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Thapsigargin; Tosyl Compounds; Tumor Cells, Cultured; Ultraviolet Rays | 2008 |
Nutrition of prostate cells.
Topics: Adenocarcinoma; Calcium; Cell Division; Cells, Cultured; Epidermal Growth Factor; Epithelial Cells; Growth Substances; Humans; Hydrocortisone; Insulin; Male; Prostate; Prostatic Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Different signals mediate transforming growth factor-beta 1-induced growth inhibition and extracellular matrix production in prostatic carcinoma cells.
Topics: Cell Division; Clone Cells; Drug Resistance; Fibronectins; Fibrosis; Genes, jun; Humans; Male; Plasminogen Activator Inhibitor 1; Prostatic Neoplasms; Receptors, Cell Surface; Receptors, Transforming Growth Factor beta; RNA; Signal Transduction; Tetradecanoylphorbol Acetate; Thymidine; Transforming Growth Factor beta; Tumor Cells, Cultured | 1993 |
Tumor-promoting phorbol ester-induced cell death and gene expression in a human prostate adenocarcinoma cell line.
Topics: Adenocarcinoma; Androgens; Base Sequence; Cell Death; Cell Division; Colforsin; Gene Expression; Gene Expression Regulation, Neoplastic; Genes, Immediate-Early; Humans; Male; Molecular Sequence Data; Prostatic Neoplasms; Tetradecanoylphorbol Acetate; Transcriptional Activation; Tumor Cells, Cultured | 1994 |
Regulation of cell growth and the c-myc proto-oncogene expression by phorbol ester 12-0-tetradecanoyl phorbol-13-acetate (TPA) in the androgen-independent human prostatic JCA-1 cells.
Topics: Androgens; Blotting, Northern; Blotting, Western; Cell Count; Cell Division; Cell Survival; DNA, Complementary; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; Infant, Newborn; Male; Prostatic Neoplasms; Proto-Oncogene Mas; Proto-Oncogene Proteins c-myc; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Phorbol ester-induced apoptosis is accompanied by NGFI-A and c-fos activation in androgen-sensitive prostate cancer cells.
Topics: Alkaloids; Androgens; Apoptosis; Carcinoma; DNA Damage; DNA-Binding Proteins; DNA, Neoplasm; Early Growth Response Protein 1; Enzyme Induction; Gene Expression Regulation, Neoplastic; Humans; Immediate-Early Proteins; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Protein Kinases; Proto-Oncogene Proteins c-fos; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Transcriptional Activation; Tumor Cells, Cultured | 1994 |
c-fos promoter insensitivity to phorbol ester and possible role of protein kinase C in androgen-independent cancer cells.
Topics: Androgens; Genes, fos; Humans; Male; Neoplasms, Hormone-Dependent; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Kinase C; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1994 |
Protein kinase C-dependent and -independent pathways of signal transduction in prostate cancer cells: fibroblast growth factor utilization of a protein kinase C-independent pathway.
Topics: Animals; Cell Division; Down-Regulation; Fibroblast Growth Factor 1; Fibroblast Growth Factors; Male; Neoplasm Proteins; Phosphorylation; Prostatic Neoplasms; Protein Kinase C; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Thymidine; Tumor Cells, Cultured; Vanadates | 1995 |
Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Line; Enzyme Activation; Female; HL-60 Cells; Humans; Male; Paclitaxel; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-raf; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Defects in p21WAF1/CIP1, Rb, and c-myc signaling in phorbol ester-resistant cancer cells.
Topics: Breast Neoplasms; Carcinogens; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Down-Regulation; Drug Resistance; Female; Genes, myc; Humans; Male; Neoplasm Proteins; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-myc; Retinoblastoma Protein; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1997 |
Persistent membrane translocation of protein kinase C alpha during 12-0-tetradecanoylphorbol-13-acetate-induced apoptosis of LNCaP human prostate cancer cells.
Topics: Apoptosis; Cytoplasm; Down-Regulation; Drug Resistance, Neoplasm; Humans; Immunoblotting; Isoenzymes; Male; Membranes; Prostate; Prostatic Neoplasms; Protein Kinase C; Protein Kinase C-alpha; RNA, Antisense; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1996 |
Coordinated expression of matrilysin during TPA-induced apoptosis of LNCaP cells: two parallel processes affected by TPA.
Topics: Apoptosis; Carcinogens; Cell Count; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Humans; Male; Matrix Metalloproteinase 7; Metalloendopeptidases; Prostatic Neoplasms; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1997 |
Androgenic induction of prostate-specific antigen gene is repressed by protein-protein interaction between the androgen receptor and AP-1/c-Jun in the human prostate cancer cell line LNCaP.
Topics: Androgens; Carcinogens; DNA, Neoplasm; Gene Expression; Humans; Male; Promoter Regions, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Binding; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Androgen; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Cells, Cultured | 1997 |
Development of a hammerhead ribozyme against bcl-2. I. Preliminary evaluation of a potential gene therapeutic agent for hormone-refractory human prostate cancer.
Topics: Base Sequence; Binding Sites; DNA-Binding Proteins; Early Growth Response Protein 1; Genes, bcl-2; Genetic Therapy; Humans; Immediate-Early Proteins; Male; Molecular Sequence Data; Nucleic Acid Conformation; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; RNA, Catalytic; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factors; Transfection; Tumor Cells, Cultured; Zinc Fingers | 1997 |
Requirement for matrix metalloproteinase-9 (gelatinase B) expression in metastasis by murine prostate carcinoma.
Topics: Animals; Carcinoma; Collagenases; Female; Gelatinases; Lung Neoplasms; Male; Matrix Metalloproteinase 9; Mice; Mice, Nude; Prostatic Neoplasms; RNA, Catalytic; RNA, Messenger; Tetradecanoylphorbol Acetate; Transfection; Transforming Growth Factor beta | 1998 |
The protein kinase C activator, phorbol ester, elicits disparate functional responses in androgen-sensitive and androgen-independent human prostatic cancer cells.
Topics: Androgens; Cell Division; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, Immediate-Early; Genes, jun; Genes, myc; Humans; Male; Prostatic Neoplasms; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Fibroblast growth factor-2 and TPA enhance prostate-cancer-cell proliferation and activate members of the Ras and PKC signal transduction pathways.
Topics: Animals; Cell Division; DNA, Antisense; Enzyme Activation; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Isoenzymes; Kinetics; Male; Prostatic Neoplasms; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-epsilon; ras Proteins; Rats; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1997 |
Regulation of a promoter of the fibroblast growth factor 1 gene in prostate and breast cancer cells.
Topics: Androgens; Base Sequence; Blood; Breast Neoplasms; Cell Line; Consensus Sequence; DNA, Complementary; Fibroblast Growth Factor 1; Gene Expression Regulation, Neoplastic; Humans; Male; Molecular Sequence Data; Promoter Regions, Genetic; Prostatic Neoplasms; RNA, Messenger; Sequence Analysis; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1998 |
Identification of positive and negative regulator elements for the tissue inhibitor of metalloproteinase 1 gene.
Topics: Base Sequence; Carcinogens; Chloramphenicol O-Acetyltransferase; Cloning, Molecular; Deoxyribonuclease I; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, Regulator; Humans; Interleukin-10; Interleukin-6; Male; Molecular Sequence Data; Promoter Regions, Genetic; Prostatic Neoplasms; Regulatory Sequences, Nucleic Acid; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1; Tumor Cells, Cultured; Up-Regulation | 1998 |
Overexpression of c-Myc inhibits p21WAF1/CIP1 expression and induces S-phase entry in 12-O-tetradecanoylphorbol-13-acetate (TPA)-sensitive human cancer cells.
Topics: Adenoviridae; Apoptosis; Blotting, Western; Breast Neoplasms; Bromodeoxyuridine; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Kinetics; Luciferases; Male; Prostatic Neoplasms; Proto-Oncogene Proteins c-myc; S Phase; Tetradecanoylphorbol Acetate; Thymidine; Time Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1999 |
Molecular mechanisms of androgen-independent growth of human prostate cancer LNCaP-AI cells.
Topics: Androgens; Apoptosis; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA Fragmentation; Enzyme Inhibitors; Gene Expression; Humans; Male; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Receptors, Androgen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Reversal of radiation resistance in LNCaP cells by targeting apoptosis through ceramide synthase.
Topics: Animals; Apoptosis; Ceramides; Enzyme Activation; Humans; Male; Mice; Mice, Nude; Oxidoreductases; Prostatic Neoplasms; Radiation Tolerance; Radiation-Sensitizing Agents; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. An underlying mechanism of its tumor-suppressive function in prostate cancer.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Apoptosis Regulatory Proteins; COS Cells; Genes, Tumor Suppressor; Humans; Male; Molecular Sequence Data; Phosphorylation; Prostatic Neoplasms; Protein Kinase C; Proteins; Serine; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Suppressor Proteins | 1999 |
Rapid signalling by androgen receptor in prostate cancer cells.
Topics: Adenocarcinoma; Androgen Antagonists; Cell Nucleus; Cytoplasm; Dihydrotestosterone; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Indoles; Ligands; Male; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Prostatic Neoplasms; Protein Kinase C; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Receptors, Androgen; Recombinant Fusion Proteins; Testosterone; Tetradecanoylphorbol Acetate; Transcription Factors; Transfection; Tumor Cells, Cultured | 1999 |
The pyruvate dehydrogenase E1 alpha gene is testosterone and prolactin regulated in prostate epithelial cells.
Topics: Animals; Cells, Cultured; Epithelial Cells; Gene Expression Regulation; Humans; Isoenzymes; Male; Prolactin; Prostate; Prostatic Neoplasms; Pyruvate Dehydrogenase Complex; Rats; Rats, Wistar; RNA, Messenger; Testosterone; Tetradecanoylphorbol Acetate; Tissue Distribution | 2000 |
Involvement of protein kinase C delta (PKCdelta) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells. Lack of proteolytic cleavage of PKCdelta.
Topics: Apoptosis; Enzyme Activation; Humans; Isoenzymes; Male; Mutation; Prostatic Neoplasms; Protein Kinase C; Protein Kinase C-delta; Recombinant Proteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.
Topics: Carrier Proteins; Chromones; Culture Media, Serum-Free; DNA-Binding Proteins; Endothelial Growth Factors; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunophilins; Lymphokines; Male; Morpholines; Neovascularization, Pathologic; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Induction of KAI-1 expression in metastatic cancer cells by phorbol esters.
Topics: Antigens, CD; Carcinogens; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Kangai-1 Protein; Male; Membrane Glycoproteins; Neoplasm Metastasis; Prostatic Neoplasms; Protein Kinase C; Proto-Oncogene Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Effect of beta-sitosterol, a plant sterol, on growth, protein phosphatase 2A, and phospholipase D in LNCaP cells.
Topics: Apoptosis; Cell Division; Ceramides; Enzyme Activation; Humans; Male; Phospholipase D; Phosphoprotein Phosphatases; Prostatic Neoplasms; Protein Phosphatase 2; Sitosterols; Sphingomyelins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Bryostatin 1 induces prolonged activation of extracellular regulated protein kinases in and apoptosis of LNCaP human prostate cancer cells overexpressing protein kinase calpha.
Topics: Antineoplastic Agents; Apoptosis; Biological Transport; Bryostatins; Carcinogens; Cell Division; Down-Regulation; Enzyme Activation; Humans; Isoenzymes; Lactones; Macrolides; Male; Mitogen-Activated Protein Kinases; Phosphorylation; Prostatic Neoplasms; Protein Kinase C; Protein Kinase C-alpha; Proto-Oncogene Proteins c-raf; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Expression of receptor protein tyrosine phosphatase alpha mRNA in human prostate cancer cell lines.
Topics: Acid Phosphatase; Animals; Blotting, Northern; Butyrates; Carcinogens; Cattle; Dihydrotestosterone; Fetal Proteins; Gene Expression Regulation, Neoplastic; Humans; Male; Prostatic Neoplasms; Protein Tyrosine Phosphatases; Receptor-Like Protein Tyrosine Phosphatases, Class 4; Receptors, Cell Surface; RNA, Messenger; Serum Albumin, Bovine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Analysis of type T1 and T2 cytokines in patients with prostate cancer.
Topics: CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Flow Cytometry; Humans; Interferon-gamma; Interleukin-10; Interleukin-2; Interleukin-4; Ionomycin; Lymphocyte Activation; Male; Prostatic Neoplasms; Tetradecanoylphorbol Acetate; Th1 Cells; Th2 Cells | 2000 |
Tumor necrosis factor-alpha represses androgen sensitivity in the LNCaP prostate cancer cell line.
Topics: Antibiotics, Antineoplastic; Blotting, Northern; Blotting, Western; Carcinogens; Cell Division; Dactinomycin; Dihydrotestosterone; Disease Progression; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Luciferases; Male; Promoter Regions, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2000 |
Differential responsiveness of prostatic acid phosphatase and prostate-specific antigen mRNA to androgen in prostate cancer cells.
Topics: Acid Phosphatase; Androgens; Carcinogens; Cell Division; Dihydrotestosterone; Humans; Male; Phenolsulfonphthalein; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Neutral endopeptidase promotes phorbol ester-induced apoptosis in prostate cancer cells by inhibiting neuropeptide-induced protein kinase C delta degradation.
Topics: Amino Acid Sequence; Apoptosis; Bombesin; Cell Division; CSK Tyrosine-Protein Kinase; Down-Regulation; Endothelin-1; Enzyme Activation; Growth Inhibitors; Humans; Isoenzymes; Male; Molecular Sequence Data; Neprilysin; Prostatic Neoplasms; Protein Kinase C; Protein Kinase C-delta; Protein-Tyrosine Kinases; src-Family Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Resistance to growth inhibitory and apoptotic effects of phorbol ester and UCN-01 in aggressive cancer cell lines.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA, Neoplasm; Down-Regulation; Drug Resistance, Neoplasm; Formazans; Humans; Immunoblotting; Male; Prostatic Neoplasms; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tetrazolium Salts; Transfection; Tumor Cells, Cultured | 2001 |
Novel vitamin D(3) analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D(3), that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Calcitriol; Carcinoma; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Division; Cyclin-Dependent Kinase Inhibitor p27; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Leukemic; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; Leukemia, Myeloid; Male; Microtubule-Associated Proteins; Neoplasm Proteins; Phosphoric Monoester Hydrolases; Prostatic Neoplasms; PTEN Phosphohydrolase; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2001 |
Upregulation of p21(WAF1/CIP1) leads to morphologic changes and esterase activity in TPA-mediated differentiation of human prostate cancer cell line TSU-Pr1.
Topics: Adenoviridae; Blotting, Northern; Blotting, Western; Carcinogens; Cell Differentiation; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Primers; Enzyme Inhibitors; Flavonoids; Humans; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Naphthol AS D Esterase; Prostatic Neoplasms; Protein Kinase C; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 2001 |
RB activation and repression of C-MYC transcription precede apoptosis of human prostate epithelial cells.
Topics: Apoptosis; Blotting, Northern; Blotting, Western; Cell Division; Cell Line; Enzyme Activation; Epithelial Cells; Genes, myc; Genes, Retinoblastoma; Humans; Male; Phosphorylation; Prostate; Prostatic Neoplasms; Protein Kinase C; Proto-Oncogene Proteins c-myc; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 2001 |
Hypoxia-inducible factor 1alpha and 1beta proteins share common signaling pathways in human prostate cancer cells.
Topics: Blood Proteins; Carcinogens; Carrier Proteins; Cell Hypoxia; Cobalt; Dimerization; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunophilins; Male; Nuclear Proteins; Phosphoinositide-3 Kinase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Prostatic Neoplasms; Protein Subunits; Signal Transduction; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Transcription Factors; Tumor Cells, Cultured; Up-Regulation | 2001 |
Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha.
Topics: Apoptosis; Diglycerides; Enzyme Inhibitors; Humans; Isoenzymes; Lactones; Male; Phorbol 12,13-Dibutyrate; Prostatic Neoplasms; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2002 |
[Mechanism of the activation of extracellular signal-regulated kinase (ERK) in prostate cancer cell lines with different metastatic potential].
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Enzyme Activation; Humans; Male; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinases; Neoplasm Metastasis; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Receptors, Purinergic P2; Tetradecanoylphorbol Acetate | 2001 |
C-Jun N-terminal kinase is required for phorbol ester- and thapsigargin-induced apoptosis in the androgen responsive prostate cancer cell line LNCaP.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Chloromethyl Ketones; Androgens; Apoptosis; Carrier Proteins; Caspase Inhibitors; Cysteine Proteinase Inhibitors; Humans; Inhibitor of Apoptosis Proteins; JNK Mitogen-Activated Protein Kinases; Kinetics; Male; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Tetradecanoylphorbol Acetate; Thapsigargin; Transfection; Tumor Cells, Cultured; Viral Proteins | 2002 |
NF-kappa B activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer.
Topics: Androgens; Animals; Binding Sites; Enhancer Elements, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; NF-kappa B; Prostate-Specific Antigen; Prostatic Neoplasms; Tetradecanoylphorbol Acetate; Transplantation, Heterologous; Tumor Cells, Cultured | 2002 |
Protein kinase C pathway is involved in regulating the secretion of prostatic acid phosphatase in human prostate cancer cells.
Topics: Acid Phosphatase; Dihydrotestosterone; Humans; Male; Prostatic Neoplasms; Protein Kinase C; Protein Tyrosine Phosphatases; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
Luteinizing hormone-releasing hormone agonist limits DU-145 prostate cancer growth by attenuating epidermal growth factor receptor signaling.
Topics: Animals; Antineoplastic Agents, Hormonal; Cell Division; Dose-Response Relationship, Drug; Enzyme Activation; ErbB Receptors; Female; Gonadotropin-Releasing Hormone; Goserelin; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Prostatic Neoplasms; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 2002 |
Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites.
Topics: Amino Acid Sequence; Animals; Binding Sites; Chromatography, Affinity; Colforsin; COS Cells; Epidermal Growth Factor; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Ligands; Male; MAP Kinase Signaling System; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Peptides; Phosphopeptides; Phosphorylation; Plasmids; Prostatic Neoplasms; Protein Kinase C; Receptors, Androgen; Serine; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Tumor Cells, Cultured | 2002 |
Tumor-promoting phorbol ester down-regulates the androgen induction of prostate-specific antigen in a human prostatic adenocarcinoma cell line.
Topics: Alkaloids; Antigens, Neoplasm; Biomarkers, Tumor; Calcimycin; Colforsin; Dose-Response Relationship, Drug; Down-Regulation; Humans; Male; Nandrolone; Phorbols; Prostate-Specific Antigen; Prostatic Neoplasms; RNA, Messenger; Staurosporine; Testosterone Congeners; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Distribution of Thyroliberin (TRH)- and 12-O-tetradecanoylphorbol 13-acetate (TPA)-activated adenylyl cyclase in normal and neoplastic tissue with special reference to the prostate.
Topics: Adenylyl Cyclases; Animals; Humans; Male; Phorbol Esters; Pituitary Gland; Prostate; Prostatic Neoplasms; Rats; Stomach; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1988 |
Differing patterns of cytotoxicity of the phorbol ester 12-O-tetradecanoylphorbol 13-acetate in various human cell strains.
Topics: Breast Neoplasms; Cell Line; Cell Survival; Female; Fibroblasts; Humans; Kinetics; Male; Melanoma; Osteosarcoma; Phorbols; Prostatic Neoplasms; Tetradecanoylphorbol Acetate | 1985 |