tetradecanoylphorbol acetate has been researched along with Cancer of Pancreas in 70 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (21.43) | 18.7374 |
| 1990's | 33 (47.14) | 18.2507 |
| 2000's | 13 (18.57) | 29.6817 |
| 2010's | 7 (10.00) | 24.3611 |
| 2020's | 2 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Capasso, M; McNeish, IA; Spear, S | 1 |
| Fujiwara, T; Ito, A; Kagawa, S; Kajioka, H; Kikuchi, S; Kuroda, S; Noma, K; Sakamoto, S; Tazawa, H; Umeda, Y; Yoshida, R; Yoshimoto, M | 1 |
| Akita, H; Asuka, T; Eguchi, H; Ito, N; Kamada, Y; Miyoshi, E; Mori, S; Morii, E; Morishita, K; Motooka, K; Nojima, S; Otsu, R; Sakata, N; Takamatsu, S; Yamada, M | 1 |
| García-Mata, R; Goicoechea, SM; Hwang, RF; Kim, HJ; McCulloch, CG; Otey, CA; Sharek, L; Staub, J; Urrutia, R; Valdivia, A; Yeh, JJ | 1 |
| Cao, K; Chang, R; Du, Z; Huang, H; Li, D; Lin, W; Malik, S; Van Doren, J; Wang, H; Zhang, K; Zhang, Q; Zheng, X | 1 |
| Altevogt, P; Arlt, A; Bondong, S; Erbe-Hoffmann, N; Hazin, J; Kiefel, H; Müerköster, SS; Pfeifer, M; Riedle, S; Schäfer, H; Wolf, J | 1 |
| Fukayama, M; Fukushima, N; Ishikawa, S; Kokudo, N; Shibahara, J; Shinozaki, A; Tanaka, M; Umeda, M | 1 |
| Hirata, K; Ito, T; Kojima, T; Kyuno, D; Murata, M; Sawada, N; Takasawa, A; Tanaka, S; Tsujiwaki, M; Yamaguchi, H | 1 |
| Conney, AH; Cui, XX; Gao, Z; Huang, MT; Liu, Y; Rabson, AB; Verano, M; Zheng, X | 1 |
| Fukazawa, H; Ishino, K; Kuroki, T; Ohba, M; Shikano, M; Uehara, Y | 1 |
| Biallek, M; Jonat, W; Maass, N; Nagasaki, K; Rösel, F; Schem, C; von Kaisenberg, C | 1 |
| Avila, GE; Chang, RL; Conney, AH; Crowell, P; Cui, XX; Hansson, A; Lin, Y; Lou, YR; Lu, YP; Rabson, AB; Ryan, AD; Shih, WJ; Suh, J; Zheng, X | 1 |
| Baj-Krzyworzeka, M; Baran, J; Brański, P; Ratajczak, MZ; Szatanek, R; Urbanowicz, B; Weglarczyk, K; Zembala, M | 1 |
| Burghardt, B; Elliott, AC; Rácz, GZ; Szlávik, V; Szucs, A; Vág, J; Varga, G | 1 |
| Ahn, DH; Basbaum, CB; Crawley, S; Gum, J; Hokari, R; Kato, S; Kim, JW; Kim, YS; Kwon, SW; Miura, S | 1 |
| Adrian, TE; Bell, RH; Ding, XZ; Flesche, JB; Robin, TP; Salabat, MR; Talamonti, MS; Ujiki, MB | 1 |
| Bond, JA; Errington, R; Gescher, AJ; Lemoine, NR; Smith, PJ; Verschoyle, RD; Wiltshire, M; Wynford-Thomas, D | 1 |
| Brocklehurst, KW; Hutton, JC; Peshavaria, M | 1 |
| Marsh, WH; Parsa, I; Sutton, AL | 1 |
| Gomez, G; Greeley, GH; Townsend, CM; Udupi, V; Zhang, T | 1 |
| Bayna, EM; Cheresh, DA; Klemke, RL; Yebra, M | 1 |
| Ausiello, DA; Breuer, W; Cabantchik, IZ; Glickstein, H; Kartner, N; Riordan, JR | 1 |
| Adogu, AA; Ashford, ML; Hales, CN; Khan, RN; Ozanne, SE | 1 |
| Beauchamp, RD; Evers, BM; Gomez, G; Ishizuka, J; Rajaraman, S; Thompson, JC; Townsend, CM; Udupi, V; Yanaihara, N; Zhang, T | 1 |
| Brodt-Eppley, J; Hui, DY | 1 |
| Pradayrol, L; Sarfati, PD; Scemama, JL; Seva, C; Vaysse, N | 1 |
| Buchler, MW; Friess, H; Funatomi, H; Kobrin, MS; Korc, M; Stathis, P | 1 |
| Bode, HP; Göke, B | 1 |
| Funakoshi, A; Ikeda, S; Jimi, A; Miyazaki, K; Ryu, S; Shinozaki, H; Yasunami, Y | 1 |
| Demura, H; Emoto, N; Isozaki, O; Murakami, H; Ohmura, E; Onoda, N; Robins, RK; Shizume, K; Tsushima, T; Wakai, K | 1 |
| Arkhammar, P; Berggren, PO; Bokvist, K; Hallberg, A; Nilsson, T; Rorsman, P; Sjöholm, A; Welsh, M; Welsh, N | 1 |
| Aicardi, G; Carbone, E; Platano, D; Pollo, A | 1 |
| Hoenig, M; Knutson, KL | 1 |
| Dolci, W; Thorens, B; Widmann, C | 1 |
| Deeg, MA; Verchere, CB | 1 |
| Harris, TE; Jones, PM; Persaud, SJ | 1 |
| Sharp, GW; Tang, SH | 1 |
| Ashcroft, SJ; Johnson, G; Tian, YA | 1 |
| Daly, JM; Dannenberg, AJ; Fahey, TJ; Koki, AT; Masferrer, JL; Soslow, RA; Teng, L; Tucker, ON; Woerner, BM; Yang, EK; Zhang, F | 1 |
| Borboni, P; Ferri, GL; Levi, A; Possenti, R; Rinaldi, AM; Trani, E | 1 |
| Biden, TJ; Ludowyke, RI; Wilson, JR | 1 |
| Farrelly, ER; Ho, JJ; Kim, YS | 1 |
| Aust, G; Nguyen, TB; Scherbaum, WA; Seissler, J; Steinbrenner, H | 1 |
| Brembeck, FH; Detjen, KM; Haller, H; Kaiser, A; Rosewicz, S; Welzel, M; Wiedenmann, B | 1 |
| Appert, HE; Bartsch, JE; Howard, JM; Iwamura, T; Staren, ED; Yang, X | 1 |
| Ding, WQ; Holicky, E; Miller, LJ | 1 |
| Haq, M; Rosemurgy, AS; Shaeii, AE; Zervos, EE | 1 |
| Ban, J; Weber, G | 1 |
| Funakoshi, A; Kitayama, N; Matsuoka, Y; Tateishi, K | 1 |
| Clemente, F; Clerc, P; Estival, A; Tam, JP; Vaysse, N | 1 |
| D'Ambra, R; Efrat, S; Fleischer, N; Starr, RG; Surana, M | 1 |
| Bastié, MJ; Williams, JA | 1 |
| Koeffler, HP; Ross, HJ; Sato, N; Ueyama, Y | 1 |
| Glinsmann-Gibson, BJ; Korc, M | 1 |
| Kamiya, Y; Murakami, H; Ohmura, E; Okada, M; Onoda, N; Shizume, K; Tsushima, T | 1 |
| Hirai, M; Kobayashi, M; Shimizu, N | 1 |
| Clémente, F; Estival, A; Oustry, P; Pradayrol, L; Vaysse, N | 1 |
| Danoff, A; Fleischer, N; Pasmantier, R; Schubart, UK | 1 |
| Arkhammar, P; Berggren, PO; Rorsman, P | 1 |
| Gamou, S; Hirai, M; Kobayashi, M; Shimizu, N | 1 |
| Russo, LL; Sharp, GW; Yada, T | 1 |
| Estival, A; Lherisson, C; Pradayrol, L; Vaysse, N | 1 |
| Arkhammar, P; Berggren, PO; Nilsson, T | 1 |
| Levy, BL; Monaco, ME; Richardson, SB | 1 |
| Shimizu, N | 1 |
| Kumae, S; Ono, J; Sato, Y; Takaki, R | 1 |
| Boosman, A; Csejtey, J | 1 |
| Broxmeyer, HE; Csejtey, J; Kawasaki, ES; Lee, MT; Ralph, P; Stanley, ER; Warren, MK; Weaver, JF; Williams, DE | 1 |
| Birt, DF; Bresnick, E; Pelling, JC; Pour, PM; Schweickert, L; Tibbels, MG | 1 |
| Carter, TH; Zelinsky-Papez, K; Zimmerman, JA | 1 |
70 other study(ies) available for tetradecanoylphorbol acetate and Cancer of Pancreas
| Article | Year |
|---|---|
Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity.
Topics: Animals; Antineoplastic Agents; Cell Separation; Cytokines; Flow Cytometry; Humans; Mice; Neoplasm Transplantation; Pancreatic Neoplasms; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate; Tumor Microenvironment | 2019 |
Targeting neutrophil extracellular traps with thrombomodulin prevents pancreatic cancer metastasis.
Topics: Animals; Apoptosis; Carcinogens; Cell Proliferation; Disease Models, Animal; Epithelial-Mesenchymal Transition; Extracellular Traps; Humans; Liver Neoplasms; Mice; Neutrophils; Pancreatic Neoplasms; Reperfusion Injury; Tetradecanoylphorbol Acetate; Thrombomodulin; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2021 |
Identification of fucosylated haptoglobin-producing cells in pancreatic cancer tissue and its molecular mechanism.
Topics: Cell Differentiation; Cell Line, Tumor; Culture Media, Conditioned; Gene Expression Regulation; Glycosylation; Haptoglobins; Humans; Immunohistochemistry; Leukemia; Macrophages; Pancreatic Neoplasms; Protein Precursors; Tetradecanoylphorbol Acetate; THP-1 Cells; Tumor Microenvironment | 2021 |
Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts.
Topics: Animals; Carcinoma, Pancreatic Ductal; cdc42 GTP-Binding Protein; Cell Movement; Cell Surface Extensions; Coculture Techniques; Cytoskeletal Proteins; Extracellular Matrix; Fibroblasts; Humans; Mice; Neoplasm Invasiveness; Neoplasm Transplantation; Pancreatic Neoplasms; Pancreatic Stellate Cells; Phosphoproteins; Protein Transport; Tetradecanoylphorbol Acetate | 2014 |
Combination of 12-O-tetradecanoylphorbol-13-acetate with diethyldithiocarbamate markedly inhibits pancreatic cancer cell growth in 3D culture and in immunodeficient mice.
Topics: Animals; Apoptosis; Cell Line, Tumor; Ditiocarb; Heterografts; Humans; Mice; Mice, Nude; Neoplasm Proteins; Neoplasm Transplantation; Pancreatic Neoplasms; Tetradecanoylphorbol Acetate; Xenograft Model Antitumor Assays | 2015 |
L1CAM-integrin interaction induces constitutive NF-kappaB activation in pancreatic adenocarcinoma cells by enhancing IL-1beta expression.
Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Adhesion; Cell Growth Processes; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Interleukin-1beta; Mice; Mice, Inbred NOD; Mice, SCID; Neural Cell Adhesion Molecule L1; NF-kappa B; Pancreatic Neoplasms; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection | 2010 |
Claudin-18 is an early-stage marker of pancreatic carcinogenesis.
Topics: Adenocarcinoma, Mucinous; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Carcinoma, Papillary; Cell Transformation, Neoplastic; Claudins; Enzyme Inhibitors; Humans; Indoles; Maleimides; Membrane Proteins; Pancreas; Pancreatic Neoplasms; Pancreatitis, Chronic; Protein Kinase C; Retrospective Studies; Stomach Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Protein kinase Cα inhibitor enhances the sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-4.
Topics: Animals; Cell Line, Tumor; Claudin-1; Claudin-4; Claudins; Clostridium perfringens; Down-Regulation; Enterotoxins; Enzyme Activation; Humans; Membrane Proteins; Occludin; Pancreatic Neoplasms; Protein Kinase C-alpha; Signal Transduction; Tetradecanoylphorbol Acetate; Tight Junctions | 2011 |
Effects of 12-O-tetradecanoylphorbol-13-acetate in combination with gemcitabine on Panc-1 pancreatic cancer cells cultured in vitro or Panc-1 tumors grown in immunodeficient mice.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxycytidine; Enzyme Activation; Female; Gemcitabine; Humans; MAP Kinase Kinase 4; Mice; Mice, Nude; Pancreatic Neoplasms; Tetradecanoylphorbol Acetate; Xenograft Model Antitumor Assays | 2012 |
Enhancement of anchorage-independent growth of human pancreatic carcinoma MIA PaCa-2 cells by signaling from protein kinase C to mitogen-activated protein kinase.
Topics: Cell Division; Cytosol; Enzyme Inhibitors; Humans; Isoenzymes; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Protein Kinase C; Protein Serine-Threonine Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2002 |
Leucine-zipper protein, LDOC1, inhibits NF-kappaB activation and sensitizes pancreatic cancer cells to apoptosis.
Topics: Apoptosis; Cell Division; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; NF-kappa B; Nuclear Proteins; Pancreatic Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tumor Suppressor Proteins | 2003 |
Inhibitory effects of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans retinoic acid on the growth of cultured human pancreas cancer cells and pancreas tumor xenografts in immunodeficient mice.
Topics: Animals; Apoptosis; Body Weight; Cell Cycle; Cell Proliferation; Humans; Immunohistochemistry; Male; Mice; Neoplasm Transplantation; Paclitaxel; Pancreatic Neoplasms; Phosphorylation; Prostatic Neoplasms; Protein Kinase C; Retinoblastoma Protein; Sulindac; Tetradecanoylphorbol Acetate; Transplantation, Heterologous; Tretinoin; Tumor Cells, Cultured | 2005 |
Tumour-derived microvesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes.
Topics: Adenocarcinoma; Antigens, Neoplasm; Apoptosis; Basigin; Cell Line, Tumor; Cell Membrane; Cell Survival; Chemotaxis; Colorectal Neoplasms; Gene Expression Profiling; Genes, MHC Class I; HLA Antigens; Humans; Hyaluronan Receptors; Immunophenotyping; Lung Neoplasms; Membrane Proteins; Monocytes; Neoplasm Proteins; Neoplasms; Pancreatic Neoplasms; Particle Size; Receptors, Chemokine; Receptors, Cytokine; RNA, Messenger; Tetradecanoylphorbol Acetate | 2006 |
Possible role of duration of PKC-induced ERK activation in the effects of agonists and phorbol esters on DNA synthesis in Panc-1 cells.
Topics: Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cholecystokinin; DNA; Extracellular Signal-Regulated MAP Kinases; Humans; Neurotensin; Pancreatic Neoplasms; Phorbol Esters; Protein Kinase C; Protein Kinase C-epsilon; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection | 2006 |
MUC5AC mucin gene regulation in pancreatic cancer cells.
Topics: Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Electrophoretic Mobility Shift Assay; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; JNK Mitogen-Activated Protein Kinases; Luciferases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mucin 5AC; Mucins; Pancreatic Neoplasms; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase Inhibitors; RNA, Messenger; Sp1 Transcription Factor; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic; Transfection | 2006 |
On the mechanisms of 12-O-tetradecanoylphorbol-13-acetate-induced growth arrest in pancreatic cancer cells.
Topics: Cell Division; Cell Line, Tumor; Cell Proliferation; Cyclin A; Cyclin B; Cyclin B1; Cyclin E; Cyclin-Dependent Kinase Inhibitor p21; Flavonoids; G2 Phase; Gene Expression Regulation, Neoplastic; Humans; Indoles; Maleimides; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Pancreatic Neoplasms; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; RNA, Messenger; Tetradecanoylphorbol Acetate | 2006 |
Cytotoxic action of phorbol esters on human pancreatic cancer cells.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Indoles; Inhibitory Concentration 50; Intracellular Signaling Peptides and Proteins; Maleimides; Membrane Proteins; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Pancreatic Neoplasms; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Xenograft Model Antitumor Assays | 2007 |
Phorbol ester stimulation of insulin release and secretory-granule protein phosphorylation in a transplantable rat insulinoma.
Topics: Adenoma, Islet Cell; Animals; Cytoplasmic Granules; Electrophoresis, Polyacrylamide Gel; In Vitro Techniques; Insulin; Insulinoma; Membrane Proteins; Pancreatic Neoplasms; Phorbols; Phosphorylation; Protein Kinase C; Protein Kinases; Rats; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1984 |
An in vitro model of pancreas carcinogenesis: two-stage MNU--TPA effect.
Topics: Animals; Cell Transformation, Neoplastic; Hyperplasia; Methylnitrosourea; Mice; Mice, Nude; Models, Biological; Necrosis; Neoplasm Transplantation; Nitrosourea Compounds; Organ Culture Techniques; Pancreas; Pancreatic Neoplasms; Phorbols; Rats; Tetradecanoylphorbol Acetate; Transplantation, Heterologous | 1980 |
Downregulation of prohormone convertase-1 by a phorbol ester.
Topics: Aspartic Acid Endopeptidases; Carcinoid Tumor; Chromogranin A; Chromogranins; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Pancreatic Hormones; Pancreatic Neoplasms; Proprotein Convertases; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin.
Topics: Cell Adhesion; Cell Line; Cell Movement; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Genistein; Glycoproteins; Humans; Insulin-Like Growth Factor I; Integrins; Isoflavones; Kinetics; Naphthalenes; Nitriles; Pancreatic Neoplasms; Phosphotyrosine; Polycyclic Compounds; Protein Kinase C; Receptor Protein-Tyrosine Kinases; Receptor, IGF Type 1; Receptors, Vitronectin; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Tyrphostins; Vitronectin | 1994 |
Protein kinase C mediates down-regulation of cystic fibrosis transmembrane conductance regulator levels in epithelial cells.
Topics: Adenocarcinoma; Colonic Neoplasms; Cycloheximide; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dactinomycin; Epithelium; Gene Expression Regulation, Neoplastic; Humans; Indoles; Maleimides; Membrane Proteins; Pancreatic Neoplasms; Protein Biosynthesis; Protein Kinase C; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1993 |
Dissociation of KATP channel and sulphonylurea receptor in the rat clonal insulin-secreting cell line, CRI-D11.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cell Membrane; Clone Cells; Glyburide; Insulin; Insulin Secretion; Insulinoma; Membrane Potentials; Pancreatic Neoplasms; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Sulfonylurea Receptors; Tetradecanoylphorbol Acetate; Tolbutamide; Tumor Cells, Cultured | 1993 |
Phorbol ester-induced alteration in the pattern of secretion and storage of chromogranin A and neurotensin in a human pancreatic carcinoid cell line.
Topics: Analysis of Variance; Blotting, Northern; Calcimycin; Carcinoid Tumor; Cell Division; Cell Line; Chromogranin A; Chromogranins; Dose-Response Relationship, Drug; Gene Expression; Humans; Ionomycin; Kinetics; Methionine; Neurotensin; Pancreatic Hormones; Pancreatic Neoplasms; Peptide Fragments; RNA, Messenger; Sulfur Radioisotopes; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1995 |
Calcium mobilization and protein kinase C activation are required for cholecystokinin stimulation of pancreatic cholesterol esterase secretion.
Topics: Animals; Calcimycin; Calcium; Cholecystokinin; Egtazic Acid; Enzyme Activation; Pancreas; Pancreatic Neoplasms; Protein Kinase C; Rats; Sterol Esterase; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Coupling of pancreatic gastrin/cholecystokinin-B (G/CCKB) receptors to phospholipase C and protein kinase C in AR4-2J tumoral cells.
Topics: Alkaloids; Animals; Binding Sites; Cholecystokinin; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Gastrins; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Ornithine Decarboxylase; Pancreas; Pancreatic Neoplasms; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Protein Kinase C; Rats; Receptors, Cholecystokinin; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Type C Phospholipases | 1994 |
Induction and expression of heparin-binding EGF-like growth factor in human pancreatic cancer.
Topics: Blotting, Northern; Epidermal Growth Factor; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Pancreatic Neoplasms; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Protein kinase C activates capacitative calcium entry in the insulin secreting cell line RINm5F.
Topics: Alkaloids; Animals; Biological Transport; Calcium; Cytosol; Insulin; Insulin Secretion; Insulinoma; Manganese; Pancreatic Neoplasms; Protein Kinase C; Rats; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured | 1994 |
In vitro release of vasoactive intestinal polypeptide and pancreatic polypeptide from human VIPoma cells and its inhibition by somatostatin analogue (SMS 201-995).
Topics: Adult; Atropine; Carbachol; Ceruletide; Dose-Response Relationship, Drug; Female; Humans; Immunohistochemistry; Microscopy, Phase-Contrast; Octreotide; Pancreatic Neoplasms; Pancreatic Polypeptide; Tetradecanoylphorbol Acetate; Theophylline; Tumor Cells, Cultured; Vasoactive Intestinal Peptide; Vipoma | 1994 |
Inhibition of human pancreatic cancer cell (MIA PaCa-2) growth by cholera toxin and 8-chloro-cAMP in vitro.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cholera Toxin; Colforsin; Cyclic AMP; Drug Synergism; Epidermal Growth Factor; Humans; Immunologic Factors; Insulin-Like Growth Factor I; Pancreatic Neoplasms; Proto-Oncogene Proteins p21(ras); Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Neoplasm; Eflornithine; Glucose; Glyburide; Inositol Phosphates; Insulin; Insulin Secretion; Insulinoma; Kinetics; Pancreatic Neoplasms; Polyamines; Potassium; Putrescine; Rats; RNA, Messenger; Spermidine; Spermine; Tetradecanoylphorbol Acetate; Theophylline; Tolbutamide; Tumor Cells, Cultured | 1993 |
Up-regulation of L- and non-L, non-N-type Ca2+ channels by basal and stimulated protein kinase C activation in insulin-secreting RINm5F cells.
Topics: Adenosine Triphosphate; Animals; Barium; Cadmium; Cadmium Chloride; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Line; Chlorides; Enzyme Activation; Insulinoma; Kinetics; Membrane Potentials; Nifedipine; omega-Conotoxin GVIA; Pancreatic Neoplasms; Patch-Clamp Techniques; Peptides; Protein Kinases; Rats; Regression Analysis; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1996 |
Regulation of distinct pools of protein kinase C delta in beta cells.
Topics: Animals; Biological Transport; Enzyme Activation; Glucose; Insulin; Insulinoma; Islets of Langerhans; Isoenzymes; Male; Oleic Acid; Pancreatic Neoplasms; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1996 |
Desensitization and phosphorylation of the glucagon-like peptide-1 (GLP-1) receptor by GLP-1 and 4-phorbol 12-myristate 13-acetate.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Indoles; Insulinoma; Molecular Sequence Data; Pancreatic Neoplasms; Peptide Fragments; Phosphorylation; Protein Kinase C; Protein Precursors; Rats; Receptors, Glucagon; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Regulation of glycosylphosphatidylinositol-specific phospholipase D secretion from beta TC3 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cycloheximide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Immunohistochemistry; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Mice; Pancreatic Neoplasms; Peptide Fragments; Phospholipase D; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Gö 6976: an inhibitor of Ca2+/DAG-dependent protein kinase C isoforms in islets of Langerhans.
Topics: Animals; Calcium; Carbazoles; Cells, Cultured; Cricetinae; Diglycerides; Enzyme Inhibitors; Glucose; Indoles; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Isoenzymes; Kinetics; Pancreatic Neoplasms; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Atypical protein kinase C isozyme zeta mediates carbachol-stimulated insulin secretion in RINm5F cells.
Topics: Animals; Carbachol; Cell Membrane; Cytosol; Enzyme Activation; Enzyme Inhibitors; Insulin; Insulin Secretion; Insulinoma; Isoenzymes; Pancreatic Neoplasms; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Sulfonylureas enhance exocytosis from pancreatic beta-cells by a mechanism that does not involve direct activation of protein kinase C.
Topics: Animals; Calcium; Enzyme Activation; Exocytosis; Glyburide; Guanosine 5'-O-(3-Thiotriphosphate); Hypoglycemic Agents; Insulinoma; Islets of Langerhans; Isoenzymes; Mice; Pancreatic Neoplasms; Phosphatidylserines; Potassium Channels; Protein Kinase C; Sulfonylurea Compounds; Tetradecanoylphorbol Acetate; Tolbutamide; Tumor Cells, Cultured | 1998 |
Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer.
Topics: Adenocarcinoma; beta 2-Microglobulin; Cyclooxygenase 2; DNA Primers; Enzyme Induction; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Isoenzymes; Kinetics; Membrane Proteins; Pancreatic Neoplasms; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1999 |
Expression, processing, and secretion of the neuroendocrine VGF peptides by INS-1 cells.
Topics: Animals; Bucladesine; Chloramphenicol O-Acetyltransferase; Cyclic AMP; Gene Expression Regulation, Neoplastic; Glucose; Insulin; Insulin Secretion; Insulinoma; Kinetics; Neuropeptides; Pancreatic Neoplasms; PC12 Cells; Protein Biosynthesis; Proteins; Rats; Recombinant Fusion Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1999 |
Increases in phosphorylation of the myosin II heavy chain, but not regulatory light chains, correlate with insulin secretion in rat pancreatic islets and RINm5F cells.
Topics: Animals; Cells, Cultured; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Myosin Heavy Chains; Myosin Light Chains; Myosin-Light-Chain Kinase; Pancreatic Neoplasms; Peptide Mapping; Phosphates; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Potassium Chloride; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Phorbol ester reduces phosphorylation of epidermal growth factor receptor in pancreatic cancer cells by activation of a tyrosine phosphatase.
Topics: Cell Membrane; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Kinetics; Organometallic Compounds; Pancreatic Neoplasms; Phenanthrolines; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrphostins | 1999 |
Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Autoantigens; Colforsin; Cyclic AMP; Gene Expression Regulation; Glucagon; Glucose; Insulinoma; Islets of Langerhans; Kinetics; Membrane Proteins; Pancreatic Neoplasms; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Rats; Receptor-Like Protein Tyrosine Phosphatases, Class 8; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Somatostatin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Activation of protein kinase Calpha inhibits growth of pancreatic cancer cells via p21(cip)-mediated G(1) arrest.
Topics: Apoptosis; Biological Transport; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Cell Nucleus; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA Replication; Humans; Isoenzymes; Pancreatic Neoplasms; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Serine-Threonine Kinases; Recombinant Proteins; Retinoblastoma Protein; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Invasiveness and MMP expression in pancreatic carcinoma.
Topics: Biocompatible Materials; Carcinoma; Collagen; Concanavalin A; Drug Combinations; Extracellular Matrix; Gels; Gene Expression Regulation, Neoplastic; Humans; Laminin; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Neoplasm Invasiveness; Pancreatic Neoplasms; Proteoglycans; Reverse Transcriptase Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured | 2001 |
Glucose and forskolin regulate IAPP gene expression through different signal transduction pathways.
Topics: Adenylyl Cyclase Inhibitors; Amyloid; Blotting, Northern; Carcinoma, Pancreatic Ductal; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Glucose; Humans; Islet Amyloid Polypeptide; Isoquinolines; Pancreatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
In vitro and in vivo matrix metalloproteinase production by pancreatic cancer cells and by distant organs.
Topics: Animals; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Pancreatic Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Synergistic action of tiazofurin and difluorodeoxycytidine on differentiation and cytotoxicity.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Differentiation; Cell Line; Cell Survival; Deoxycytidine; Dose-Response Relationship, Drug; Drug Synergism; Female; Gemcitabine; Humans; IMP Dehydrogenase; Kinetics; Leukemia, Promyelocytic, Acute; Liver Neoplasms, Experimental; Models, Biological; Ovarian Neoplasms; Pancreatic Neoplasms; Rats; Ribavirin; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Stem Cell Assay | 1992 |
Interaction between phosphoinositide turnover system and cyclic AMP pathway for the secretion of pancreastatin and somatostatin from QGP-1N cells.
Topics: Adenoma, Islet Cell; Atropine; Bucladesine; Calcimycin; Carbachol; Cell Line; Chromogranin A; Colforsin; Cyclic AMP; Drug Synergism; Humans; Kinetics; Pancreatic Hormones; Pancreatic Neoplasms; Phosphatidylinositols; Somatostatin; Tetradecanoylphorbol Acetate; Theophylline; Tumor Cells, Cultured | 1992 |
Decreased expression of transforming growth factor alpha during differentiation of human pancreatic cancer cells.
Topics: Butyrates; Butyric Acid; Cell Differentiation; Gene Expression Regulation; Humans; Pancreatic Neoplasms; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Transforming Growth Factor beta; Tumor Cells, Cultured | 1992 |
Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Animals; Carbachol; Colforsin; Cyclic AMP; Drug Synergism; Glipizide; Glucose; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Mice; Mice, Transgenic; Pancreatic Neoplasms; Potassium; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Gastrointestinal peptides activate Na(+)-H+ exchanger in AR42J cells by increasing its affinity for intracellular H+.
Topics: Amiloride; Amino Acid Sequence; Animals; Bombesin; Carbachol; Carrier Proteins; Cell Line; Gastrointestinal Hormones; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Pancreatic Neoplasms; Pentagastrin; Rats; Sincalide; Sodium Chloride; Sodium-Hydrogen Exchangers; Substance P; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Cytokine messenger RNA stability is enhanced in tumor cells.
Topics: Adenocarcinoma; Base Sequence; Carcinoma, Hepatocellular; Cell Line; Cytokines; Gene Expression Regulation, Neoplastic; Glioma; Globins; Granulocyte-Macrophage Colony-Stimulating Factor; Kinetics; Liver Neoplasms; Lung Neoplasms; Molecular Sequence Data; Pancreatic Neoplasms; RNA, Messenger; Tetradecanoylphorbol Acetate; Transfection | 1991 |
Regulation of transforming growth factor-alpha mRNA expression in T3M4 human pancreatic carcinoma cells.
Topics: Dactinomycin; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Nucleic Acid Hybridization; Pancreatic Neoplasms; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1991 |
Insulin-like growth factor I and transforming growth factor alpha as autocrine growth factors in human pancreatic cancer cell growth.
Topics: Adult; Cell Division; Cell Line; Cells, Cultured; Fibroblasts; Humans; Insulin-Like Growth Factor I; Kinetics; Pancreatic Neoplasms; Receptors, Cell Surface; Receptors, Somatomedin; Receptors, Transforming Growth Factor beta; Recombinant Proteins; Skin; Somatomedins; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tumor Cells, Cultured | 1990 |
Reduced tyrosine phosphorylation and nonresponsiveness to EGF-mediated cytotoxicity in EGF receptor-hyperproducing UCVA-1 cells.
Topics: Carcinoma, Squamous Cell; Cell Division; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Humans; Pancreatic Neoplasms; Peptide Mapping; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1990 |
Two subclasses of EGF receptors in the human pancreatic cancer cell lines CAPAN-1 and MIA PaCa-2.
Topics: Cell Division; Cell Survival; Epidermal Growth Factor; ErbB Receptors; Humans; Pancreatic Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
P19, a hormonally regulated phosphoprotein of peptide hormone-producing cells: secretagogue-induced phosphorylation in AtT-20 mouse pituitary tumor cells and in rat and hamster insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenoma, Islet Cell; Adrenocorticotropic Hormone; Animals; Colforsin; Corticotropin-Releasing Hormone; Cricetinae; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Glucagon; Insulinoma; Isoproterenol; Pancreatic Neoplasms; Phosphoproteins; Phosphorylation; Pituitary Neoplasms; Potassium; Rats; Tetradecanoylphorbol Acetate | 1986 |
Voltage-activated Na+ currents and their suppression by phorbol ester in clonal insulin-producing RINm5F cells.
Topics: Action Potentials; Adenoma, Islet Cell; Animals; Calcium; Cell Line; Clone Cells; Insulin; Insulin Secretion; Insulinoma; Ion Channels; Membrane Potentials; Pancreatic Neoplasms; Rats; Sodium; Tetradecanoylphorbol Acetate | 1986 |
Lung cancer cells often express high levels of protein kinase C activity.
Topics: Animals; Calcium; Chromatography; Female; Humans; Lung Neoplasms; Mice; Pancreatic Neoplasms; Phosphatidylserines; Protein Kinase C; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Tongue Neoplasms; Tumor Cells, Cultured; Vulvar Neoplasms | 1989 |
Phorbol ester-stimulated insulin secretion by RINm5F insulinoma cells is linked with membrane depolarization and an increase in cytosolic free Ca2+ concentration.
Topics: Adenoma, Islet Cell; Animals; Benzofurans; Calcium; Carbachol; Cell Line; Cell Membrane; Cytosol; Ethers; Fluorescent Dyes; Fura-2; Insulinoma; Ionomycin; Kinetics; Membrane Potentials; Pancreatic Neoplasms; Potassium Chloride; Rats; Tetradecanoylphorbol Acetate | 1989 |
HPLC analysis of somatostatin peptides secreted by a rat pancreatic endocrine cell line (RINT3): stimulation studies.
Topics: Adenoma, Islet Cell; Animals; Cell Line; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Colforsin; Culture Media; Indicators and Reagents; Pancreatic Neoplasms; Peptides; Rats; Somatostatin; Spectrophotometry, Ultraviolet; Tetradecanoylphorbol Acetate | 1989 |
Activation of protein kinase C assists insulin producing cells in recovery from raised cytoplasmic Ca2+ by stimulating Ca2+ efflux.
Topics: Animals; Calcium; Cell Line; Cytosol; Dimethyl Sulfoxide; Enzyme Activation; Gallopamil; Insulin; Insulin Secretion; Insulinoma; Kinetics; Pancreatic Neoplasms; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Synergism between vasopressin and phorbol esters in stimulation of insulin secretion and phosphatidylcholine metabolism in RIN insulinoma cells.
Topics: Adenoma, Islet Cell; Animals; Arginine Vasopressin; Cell Line; Drug Synergism; Insulinoma; Kinetics; Pancreatic Neoplasms; Phloretin; Phosphatidylcholines; Rats; Tamoxifen; Tetradecanoylphorbol Acetate | 1988 |
[Regulation of EGF receptor by tumor promoters].
Topics: Animals; Carcinoma, Squamous Cell; Cell Line; ErbB Receptors; Fibroblasts; Humans; Mice; Mouth Neoplasms; Pancreatic Neoplasms; Phosphorylation; Protein Kinase C; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1986 |
Effect of phorbol esters on glucagon secretion from a glucagon-secreting clonal cell line. Synergistic effects of A23187 and theophylline.
Topics: Adenoma, Islet Cell; Animals; Calcimycin; Cell Line; Clone Cells; Cricetinae; Drug Synergism; Glucagon; In Vitro Techniques; Insulinoma; Pancreatic Neoplasms; Phorbols; Tetradecanoylphorbol Acetate; Theophylline | 1986 |
Purification of human macrophage colony stimulating factor (CSF-1) from medium conditioned by pancreatic carcinoma cells.
Topics: Base Sequence; Chromatography, Affinity; Chromatography, High Pressure Liquid; Colony-Stimulating Factors; Culture Media; DNA; Electrophoresis, Polyacrylamide Gel; Humans; Macromolecular Substances; Macrophages; Molecular Weight; Pancreatic Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Inducible production of human macrophage growth factor, CSF-1.
Topics: Animals; Bone Marrow Cells; Carcinoma; Cell Line; Colony-Stimulating Factors; Gene Expression Regulation; Humans; Macrophages; Mice; Pancreatic Neoplasms; RNA, Messenger; Tetradecanoylphorbol Acetate; Tretinoin | 1986 |
Enhanced pancreatic and skin tumorigenesis in cabbage-fed hamsters and mice.
Topics: Animals; Body Weight; Brassica; Cricetinae; Dietary Fats; Female; Gallbladder Neoplasms; Male; Mesocricetus; Mice; Nitrosamines; Pancreatic Neoplasms; Selenium; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triiodothyronine; Vitamin A | 1987 |
Isolation and characterization of chemically transformed pancreatic acinar cell lines from young and old mice.
Topics: Acetylglucosamine; Aging; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Isoenzymes; Karyotyping; L-Lactate Dehydrogenase; Lectins; Male; Methylnitrosourea; Mice; Pancreatic Neoplasms; Phenotype; Plant Lectins; Soybean Proteins; Tetradecanoylphorbol Acetate | 1987 |