tetradecanoylphorbol acetate has been researched along with Cancer of Liver in 148 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (18.92) | 18.7374 |
| 1990's | 60 (40.54) | 18.2507 |
| 2000's | 36 (24.32) | 29.6817 |
| 2010's | 21 (14.19) | 24.3611 |
| 2020's | 3 (2.03) | 2.80 |
| Authors | Studies |
|---|---|
| Li, F; Wang, L; Wang, MK; Yu, K; Zhang, XL | 1 |
| Kim, H; Kim, M | 1 |
| Fujiwara, T; Ito, A; Kagawa, S; Kajioka, H; Kikuchi, S; Kuroda, S; Noma, K; Sakamoto, S; Tazawa, H; Umeda, Y; Yoshida, R; Yoshimoto, M | 1 |
| Chang, HH; Chen, YC; Hu, CT; Hui, LC; Lee, MC; Liao, PC; Mandal, JP; Shiue, CN; Wu, WS; Yang, HH; You, RI | 1 |
| Chen, Y; Qiao, Y; Sun, F; Wang, J; Wu, Q; Zhang, X; Zhao, Y; Zhu, G | 1 |
| Cheng, CC; Hu, CT; Lee, MC; Lin, TY; Wu, WS; You, RI | 1 |
| Anzai, K; Kuwashiro, T; Matsuhashi, S; Mizuta, T; Ozaki, I; Takahashi, H; Xia, J | 1 |
| Avivi, A; Band, M; Hirsh, M; Iancu, TC; Malik, A; Manov, I; Shams, I; Sotnichenko, N | 1 |
| Chen, BC; Kao, ST; Liu, CJ; Wang, SD; Yeh, CC | 1 |
| Chen, XP; Li, T; Lu, JJ; Wang, YT; Wu, GS; Xu, WS | 1 |
| Chen, D; Feng, Z; Li, D; Li, J; Luo, L; Shi, Q; Xia, J; You, Z; Zhao, L; Zuo, G | 1 |
| Hidaka, C; Miura, T; Nishinaka, T; Okamoto, A; Okamura, A; Sakou, M; Sasaoka, C; Terada, T | 1 |
| Liu, CJ; Yeh, CC; Yen, HR | 1 |
| Murata, K; Sakamoto, A | 1 |
| Cui, J; Gao, D; Guo, K; Kang, X; Li, Y; Liu, Y; Sun, L | 1 |
| Fu, H; Li, S; Sun, Z; Tie, Y; Wang, Y; Wei, L; Xing, R; Zheng, X; Zhu, J | 1 |
| Badmaev, V; Chen, WJ; Chiou, YS; Ho, CT; Pan, MH; Wang, JM | 1 |
| Eguchi, Y; Fujimoto, K; Hamajima, H; Ide, Y; Kawaguchi, Y; Mizuta, T; Ozaki, I; Yamamoto, K; Zhang, H | 1 |
| Huang, YY; Hung, CM; Kao, ST; Lee, KH; Liu, CJ; Yeh, CC; Yeh, MH | 1 |
| Hsu, LS; Peng, CH; Shi, YS; Wang, CJ; Wu, CH; Yang, MY | 1 |
| Chen, HC; Chen, LC; Chen, SJ; Chiang, CW; Chou, CK; Huang, Y; Leong, KW | 1 |
| Tokiwa, T; Yamazaki, T | 1 |
| Chang, CS; Chao, DC; Ho, TY; Hsiang, CY; Huang, HC; Kao, ST; Liang, JA; Lin, LJ; Wu, SL | 1 |
| Chen, C; Fan, X; Ge, S; Ni, P; Qian, G; Xu, H; Yao, Y; Zhao, X | 1 |
| Fukui, R; Fukushima, N; Kato, K; Mori, T; Okabe, K; Okumura, M; Teranishi, M; Tsujiuchi, T | 1 |
| Chang, TY; Cheng, CC; Hu, CT; Lee, MC; Pan, SM; Wang, HT; Wang, LJ; Wang, S; Wu, JR; Wu, WS | 1 |
| Deng, Y; Esko, JD; Foley, EM; Gonzales, JC; Gordts, PL; Li, Y | 1 |
| Eguchi, Y; Fujimoto, K; Hamajima, H; Iwane, S; Kuroda, S; Matsuhashi, S; Mizuta, T; Ozaki, I; Takahashi, H; Xia, J | 1 |
| Chen, L; Jin, X; Li, H; Mao, J; Wang, L; Xu, B; Yuan, J; Zhang, H; Zhu, J | 1 |
| Lu, W; Ou, JH | 1 |
| Bander, E; Buday, L; Faragó, A; Gujdár, A; Sipeki, S | 1 |
| Wen-Sheng, W | 2 |
| Araya, Z; Tang, W; Wikvall, K | 1 |
| Hah, N; Lee, ST | 1 |
| Baldini, PM; Currado, L; De Vito, P; Luly, P; Novotná, R | 1 |
| Hwang, BD; Jung, YJ; Kim, TD; Lee, BH; Lee, TG; Li, G; Lim, K; Park, HD; Song, IS; Yoon, WH | 1 |
| Chang, YC; Joo, ST; Kim, CH; Park, KK; Park, WH | 1 |
| Frilling, A; Häussinger, D; Horbach, A; Kubitz, R; Schmitt, M | 1 |
| Fuchs, R; Gonçalves, C; Gorvel, JP; Mennesson, E; Midoux, P; Pichon, C | 1 |
| Liu, GT; Sun, H | 1 |
| Abidi, P; Jiang, JD; Liu, J; Zhou, Y | 1 |
| Das, M; Dogra, RK; Khanna, SK; Rastogi, S | 1 |
| Collins, J; Diwan, BA; Ducharme, DM; Liu, J; Logsdon, D; Merrick, BA; Shen, J; Waalkes, MP; Xie, Y | 1 |
| Al Sarraj, J; Bauer, I; Larsen, R; Thiel, G; Vinson, C | 1 |
| Kaneoka, Y; Kozawa, O; Kumada, T; Matsushima-Nishiwaki, R; Takai, S; Tokuda, H; Toyoda, H; Yamaguchi, A; Yasuda, E | 1 |
| Liu, ZH; Ma, D; Tai, GX; Zhang, HJ; Zhou, J | 1 |
| Chau, CF; Chen, DH; Chen, KD; Weng, CJ; Yen, GC | 1 |
| Chau, CF; Hsieh, YS; Weng, CJ; Yang, SF; Yen, GC | 1 |
| Chang, TY; Cheng, CC; Hu, CT; Wu, JR; Wu, WS | 1 |
| Thomson, DM | 1 |
| Gabrielides, C; Gross, JL; Moscatelli, D; Rifkin, DB | 1 |
| Kriegel, H; Schmahl, W; Senft, E | 1 |
| Gross, JL; Moscatelli, D; Rifkin, DB | 1 |
| Mullins, DE; Rifkin, DB | 1 |
| Hart, IR; Talmadge, JE | 1 |
| Goerttler, K; Hesse, B; Loehrke, H; Schweizer, J | 1 |
| Ferioli, ME; Scalabrino, G | 1 |
| Buening, MK; Chang, RL; Conney, AH; Jerina, DM; Lehr, RE; Levin, W; Taylor, CW; Wood, AW; Yagi, H | 1 |
| Hasegawa, R; Imaida, K; Ito, N; Murasaki, G; Tatematsu, M | 1 |
| Arbuthnot, P; Bralet, MP; Bréchot, C; Danan, JL; Ferry, N; Thomassin, H | 1 |
| Miwa, A; Okada, Y; Tominaga, M; Tominaga, T | 1 |
| Adler, GK; Arbiser, JL; Arbiser, ZK; Majzoub, JA; Martinez, C; Rosen, LB | 1 |
| Fandrey, J; Frede, S; Huwiler, A; Jelkmann, W; Pfeilschifter, J | 1 |
| Ascione, AG; Demple, B; Harrison, L; Wilson, DM | 1 |
| Irimura, T; Kakiuchi, T; Koike, C; Okada, S; Oku, N; Tsukada, H; Watanabe, M | 1 |
| Ren, Y; Smith, A | 1 |
| Chang, KS; Chen, SW; Hsu, ML; Liao, SK; Lin, KH | 1 |
| Heiman, AS; Tonner, LE | 2 |
| Elliott, HG; Elliott, MA; Smith, KD; Watson, J | 1 |
| Faquin, WC; Goldberg, MA; Schneider, TJ | 1 |
| Hirano, F; Inaba, M; Makino, I; Makino, Y; Miura, T; Okamoto, K; Tanaka, H | 1 |
| Chen, HC; Chou, CK; Lin, YL; Yeh, SF | 1 |
| Costa, RH; Porcella, A; Qian, X; Samadani, U | 1 |
| Chai, XY | 1 |
| Beyer, EC; Engelmann, GL; Laing, JG; Westphale, EM | 1 |
| Bell, GI; Hayashi, Y; Janssen, OE; Mori, Y; Refetoff, S; Seo, H; Sunthornthepvarakul, T; Takeda, K; Weinberg, M; Weiss, RE | 1 |
| Fanjul, A; Kim, SJ; Lu, XP; Pfahl, M; Piedrafita, FJ; Salbert, G; Tran, P | 1 |
| Chang, KS; Hsu, ML; Josephs, SF | 1 |
| Alessi, MC; Anfosso, F; Chomiki, N; Juhan-Vague, I; Vague, P | 1 |
| Kamps, JA; van Berkel, TJ | 1 |
| Favreau, LV; Pickett, CB | 1 |
| Parkes, DG; Vale, WW; Vaughan, JM; Yamamoto, GY | 1 |
| Chanson, M; De Jonge, HR; Hermans, MM; Jongsma, HJ; Kwak, BR; Lohmann, SM | 1 |
| Bock, KW; Gohl, G; Lehmköster, T; Münzel, PA; Schrenk, D; Viebahn, R | 1 |
| Austin, RC; Hill, SA; Joshua, P; Podor, TJ; Ribau, J; Shaughnessy, SG | 1 |
| Gu, J; Jiang, S; Shen, Z; Zhou, D | 1 |
| Inada, A; Nakanishi, T; Nishino, H; Sharma, OP; Tokuda, H | 1 |
| Andersson-Ross, C; Barkhem, T; Höglund, M; Nilsson, S | 1 |
| Butterfield, JH; Galli, SJ; Hamasaki, K; Ishii, N; Kato, Y; Nakao, K; Nakata, K; Sayama, K; Yano, K | 1 |
| Long, WP; Perdew, GH; Pray-Grant, M; Tsai, JC | 1 |
| Chou, CK; Lin, YL | 1 |
| Ainbinder, E; Bergelson, S; Daniel, V | 1 |
| Chou, YH; Hsu, SL; Liu, JY; Yin, SC | 1 |
| Fu, JZ; Zha, XL | 1 |
| Chen, C; Chi, C; Gu, J; Shen, Z; Yin, X; Zhou, D | 1 |
| Arts, J; Grimbergen, J; Kooistra, T; Toet, K | 1 |
| Calmus, Y; Conti, F; Meier, PJ; Podevin, P; Poupon, R; Rosmorduc, O | 1 |
| Ambiru, S; Ito, H; Miyazaki, M; Nakagawa, K; Nakajim, N; Nakamura, S; Nozawa, S; Nukui, Y; Okuno, A; Shimizu, H; Shimizu, Y; Yoshitomi, H | 1 |
| Cariers, A; Häussinger, D; Michalke, M; Schliess, F | 1 |
| Bácsy, E; Bander, E; Buday, L; Faragó, A; Farkas, G; Sipeki, S; Ways, DK | 1 |
| Bode, BP; Pawlik, TM; Souba, WW; Sweeney, TJ | 1 |
| Bagnis, C; Bréchot, C; Chapel, S; Gerolami, R; Jordier, F; Mannoni, P; Uch, R | 1 |
| Corcos, L; Galisteo, M; Guillouzo, A; Joannard, F; Lagadic-Gossmann, D; Lerche, C; Rissel, M | 1 |
| Joseph, SB; Kast, HR; Laffitte, BA; Mangelsdorf, DJ; Repa, JJ; Tontonoz, P; Wilpitz, DC | 1 |
| Hong, KJ; Kang, JH; Kim, SA; Um, SJ | 1 |
| Chen, HL; Liu, F; Qi, HL | 1 |
| Abe, K; Higashi, N; Hirai, M; Hirano, T; Miki, T; Mizuno, K; Nakajima, K; Sekimoto, T | 1 |
| Hsu, HY; Wu, WS | 1 |
| Chao, DC; Ho, TY; Hsiang, CY; Lai, IL | 1 |
| Sivak, A | 1 |
| Buening, MK; Chang, RL; Conney, AH; Jerina, DM; Karle, JM; Levin, W; Wood, AW; Yagi, H | 1 |
| Buening, MK; Chang, RL; Conney, AH; Jerina, DM; Levin, W; Thakker, DR; Wood, AW | 1 |
| Fukumura, D; Kagawa, T; Kurose, I; Miura, S; Morizane, T; Saito, H; Suematsu, M; Tada, S; Tsuchiya, M | 1 |
| Corvol, P; Eckardt, KU; Fabbro, D; Kurtz, A; Pugh, C; Ratcliffe, P | 1 |
| Janaswami, PM; Kalvakolanu, DV; Sen, GC; Zhang, Y | 1 |
| Izumi, N; Liu, J; Liu, JH; Marumo, F; Sakai, Y; Sato, C; Takano, T; Tang, L; Yauchi, T | 1 |
| Abdel-Maguid, LS; Lee, PD; Snuggs, MB | 1 |
| Alexander-Bridges, M; Dugast, I; Ercolani, L; Giere, L; Kong, XF; Nasrin, N | 1 |
| Hasegawa, T; Iwashima, A; Kitano, H; Murakoshi, M; Nishino, H; Okabe, H; Okuzumi, J; Satomi, Y; Takayasu, J; Tokuda, H | 1 |
| Armato, U; Carcereri dePrati, A; Menapace, L; Menegazzi, M; Miwa, M; Ribecco, M; Suzuki, H; Testolin, L | 1 |
| Adler, GK; Majzoub, JA; Rosen, LB | 1 |
| Messina, JL; Weinstock, RS | 1 |
| Fusamoto, H; Hayashi, N; Kamada, T; Kasahara, A; Katayama, K; Sasaki, Y; Takehara, T; Towata, T | 1 |
| Auwerx, J; Masure, S; Norga, K; Opdenakker, G; Proost, P; Van Damme, J; Van Ranst, M; Vandekerckhove, F | 1 |
| Bosma, PJ; Kooistra, T | 1 |
| Fandrey, J; Huwiler, A; Jelkmann, W; Pfeilschifter, J | 1 |
| Gullberg, U; Lantz, M; Lindvall, L; Olsson, I | 1 |
| Koeffler, HP; Ross, HJ; Sato, N; Ueyama, Y | 1 |
| Edwards, PA; Kutsunai, SY; Wilkin, DJ | 1 |
| Ito, N; Kawata, S; Shirai, Y; Takaishi, K; Tamura, S; Tarui, S | 1 |
| Billiau, A; Masure, S; Opdenakker, G; Van Damme, J | 1 |
| Baumann, H; Isseroff, H; Jahreis, GP; Latimer, JJ | 1 |
| Gjøen, T; Kolset, SO; Seljelid, R | 1 |
| Heffetz, D; Zick, Y | 1 |
| Kaneda, Y; Maki, H; Miwatani, H; Uchida, T; Yoneda, Y | 1 |
| Acs, G; Banerjee, R; Bauer, J; Karpen, S; Lengyel, G; Siekevitz, M | 1 |
| Briata, P; Gherzi, R; Laurino, C | 1 |
| Moser, GJ; Smart, RC | 1 |
| Buckley, AR; Putnam, CW; Russell, DH | 1 |
| Buzogany, JA; Ellison, EC; Fabri, PJ; Gower, WR; Knierim, TH | 1 |
| Jaffe, EA; Moscatelli, DA; Rifkin, DB | 1 |
| Fujiki, H; Moore, RE; Uchida, T; Yoneda, Y | 1 |
| Pelling, JC; Slaga, TJ | 1 |
| Moscatelli, D | 1 |
| Cuatrecasas, P; Jacobs, S | 1 |
| Moens, W; Rolin-Limbosch, S; Szpirer, C | 1 |
3 review(s) available for tetradecanoylphorbol acetate and Cancer of Liver
| Article | Year |
|---|---|
Polyamines in mammalian tumors. Part I.
Topics: Adenosylmethionine Decarboxylase; Animals; Carcinogens; Cells, Cultured; Liver Neoplasms; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Polyamines; Rats; Skin Neoplasms; Spermidine Synthase; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tumor Virus Infections | 1981 |
Cocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Transformation, Viral; Cocarcinogenesis; Diet; Gastrointestinal Neoplasms; Hormones; Humans; Liver Neoplasms; Lung Neoplasms; Membranes; Methylcholanthrene; Models, Biological; Neoplasms; Nutritional Physiological Phenomena; Oncogenic Viruses; Propionibacterium acnes; Protein Biosynthesis; Retroviridae; Skin Neoplasms; Tetradecanoylphorbol Acetate; Urinary Bladder Neoplasms; Vitamin A | 1979 |
Cellular mechanisms for tumor promotion and enhancement.
Topics: Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; ErbB Receptors; Humans; Kidney Neoplasms; Liver Neoplasms; Oncogenes; Protein Kinase C; Protein Kinases; Receptors, Cell Surface; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
145 other study(ies) available for tetradecanoylphorbol acetate and Cancer of Liver
| Article | Year |
|---|---|
Cytotoxic phorbol esters of Croton tiglium.
Topics: Antineoplastic Agents; Croton; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Humans; Inhibitory Concentration 50; Liver Neoplasms; Molecular Structure; Phorbol Esters; Seeds | 2013 |
Anti-Inflammatory Effect of Protopine through MAPK and NF-κB Signaling Regulation in HepG2 Cell.
Topics: Anti-Inflammatory Agents; Benzophenanthridines; Berberine Alkaloids; Cyclooxygenase 2; Hep G2 Cells; Humans; Liver Neoplasms; Matrix Metalloproteinase 9; NF-kappa B; Tetradecanoylphorbol Acetate | 2022 |
Targeting neutrophil extracellular traps with thrombomodulin prevents pancreatic cancer metastasis.
Topics: Animals; Apoptosis; Carcinogens; Cell Proliferation; Disease Models, Animal; Epithelial-Mesenchymal Transition; Extracellular Traps; Humans; Liver Neoplasms; Mice; Neutrophils; Pancreatic Neoplasms; Reperfusion Injury; Tetradecanoylphorbol Acetate; Thrombomodulin; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2021 |
PKCδ mediates mitochondrial ROS generation and oxidation of HSP60 to relieve RKIP inhibition on MAPK pathway for HCC progression.
Topics: Carcinoma, Hepatocellular; Chaperonin 60; Humans; Liver Neoplasms; MAP Kinase Signaling System; Mitochondria; Phosphatidylethanolamine Binding Protein; Protein Kinase C-delta; Reactive Oxygen Species; Tetradecanoylphorbol Acetate | 2021 |
12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT.
Topics: Angiomotins; Animals; Antineoplastic Agents; Caspase 3; Caspase 7; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Disease Models, Animal; Gene Expression; Heterografts; Humans; Intercellular Signaling Peptides and Proteins; Liver Neoplasms; Membrane Proteins; Mice; Microfilament Proteins; Nuclear Proteins; Phenotype; Protein Transport; Tetradecanoylphorbol Acetate; Transcription Factors | 2017 |
Snail collaborates with EGR-1 and SP-1 to directly activate transcription of MMP 9 and ZEB1.
Topics: Carcinoma, Hepatocellular; Early Growth Response Protein 1; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Matrix Metalloproteinase 9; Neoplasm Proteins; Promoter Regions, Genetic; Sp1 Transcription Factor; Tetradecanoylphorbol Acetate; Transcription, Genetic; Up-Regulation; Zinc Finger E-box-Binding Homeobox 1 | 2017 |
Mechanisms of PKC-Mediated Enhancement of HIF-1α Activity and its Inhibition by Vitamin K2 in Hepatocellular Carcinoma Cells.
Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Gene Knockdown Techniques; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Isoenzymes; Liver Neoplasms; Promoter Regions, Genetic; Protein Kinase C; Protein Transport; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vitamin K 2 | 2019 |
Pronounced cancer resistance in a subterranean rodent, the blind mole-rat, Spalax: in vivo and in vitro evidence.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Shape; Cell Survival; Coculture Techniques; Culture Media, Conditioned; Disease Resistance; DNA Fragmentation; Fibroblasts; Fibrosarcoma; Humans; Liver Neoplasms; Mice; Mitochondrial Dynamics; Neoplasms; Rats; Spalax; Tetradecanoylphorbol Acetate; Tumor Stem Cell Assay | 2013 |
Genistein inhibits tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Genistein; Glycine max; Hep G2 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Matrix Metalloproteinase 9; Mice; Mice, Nude; Neoplasm Invasiveness; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphorylation; Phytotherapy; Plant Extracts; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2014 |
Platycodin D induces apoptosis, and inhibits adhesion, migration and invasion in HepG2 hepatocellular carcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Hep G2 Cells; Humans; Inhibitor of Apoptosis Proteins; Liver Neoplasms; Medicine, Chinese Traditional; Neoplasm Invasiveness; Plant Extracts; Poly(ADP-ribose) Polymerases; Saponins; Survivin; Tetradecanoylphorbol Acetate; Triterpenes; Up-Regulation | 2014 |
Effect of ginsenoside Rh2 on the migratory ability of HepG2 liver carcinoma cells: recruiting histone deacetylase and inhibiting activator protein 1 transcription factors.
Topics: Cell Movement; Down-Regulation; Ginsenosides; Hep G2 Cells; Histone Deacetylases; Humans; Liver Neoplasms; Matrix Metalloproteinase 3; Repressor Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2014 |
Down-regulation of aldo-keto reductase AKR1B10 gene expression by a phorbol ester via the ERK/c-Jun signaling pathway.
Topics: Aldehyde Reductase; Aldo-Keto Reductases; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Humans; Liver Neoplasms; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinases; Phorbol Esters; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate | 2015 |
Naringenin suppresses TPA-induced tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cell Movement; Flavanones; Hep G2 Cells; Humans; I-kappa B Proteins; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Mice; Neoplasm Invasiveness; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphorylation; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2015 |
Impairment of clathrin-mediated endocytosis via cytoskeletal change by epithelial to fibroblastoid conversion in HepG2 cells: a possible mechanism of des-gamma-carboxy prothrombin production in hepatocellular carcinoma.
Topics: Actins; Biomarkers; Biomarkers, Tumor; Bridged Bicyclo Compounds, Heterocyclic; Cadherins; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Transdifferentiation; Clathrin; Cytoskeleton; Dose-Response Relationship, Drug; Endocytosis; Epithelial Cells; Fibroblasts; Humans; Lipoproteins, LDL; Liver Neoplasms; Protein Precursors; Prothrombin; Tetradecanoylphorbol Acetate; Thiazolidines; Vitamin K 2 | 2008 |
Role of PKCbeta in hepatocellular carcinoma cells migration and invasion in vitro: a potential therapeutic target.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Humans; Indoles; Liver Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Protein Kinase C; Protein Kinase C beta; RNA Interference; Tetradecanoylphorbol Acetate | 2009 |
MicroRNA-101 regulates expression of the v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) oncogene in human hepatocellular carcinoma.
Topics: 3' Untranslated Regions; Adult; Aged; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, Reporter; Humans; Liver Neoplasms; Male; MicroRNAs; Middle Aged; Pancreatitis-Associated Proteins; Proto-Oncogene Proteins c-fos; RNA, Messenger; Sequence Analysis, DNA; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2009 |
Pterostilbene inhibited tumor invasion via suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Movement; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Lung Neoplasms; Matrix Metalloproteinase 9; Mice; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Neoplasm Transplantation; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Signal Transduction; Stilbenes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transplantation, Heterologous | 2009 |
Inhibition of matrix metalloproteinase expression by menatetrenone, a vitamin K2 analogue.
Topics: Carcinoma, Hepatocellular; Humans; Liver Neoplasms; MAP Kinase Signaling System; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; NF-kappa B; Protease Inhibitors; Protein Kinase C; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Vitamin K 2 | 2009 |
The inhibitory effect of hesperidin on tumor cell invasiveness occurs via suppression of activator protein 1 and nuclear factor-kappaB in human hepatocellular carcinoma cells.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Hesperidin; Humans; I-kappa B Kinase; Liver Neoplasms; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; NF-kappa B; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2010 |
Polyphenol-rich extracts from Solanum nigrum attenuated PKC alpha-mediated migration and invasion of hepatocellular carcinoma cells.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Flavonoids; Humans; Liver Neoplasms; Phenols; Phosphorylation; Plant Extracts; Polyphenols; Protein Kinase C-alpha; Solanum nigrum; Tetradecanoylphorbol Acetate | 2010 |
PKCalpha mediated induction of miR-101 in human hepatoma HepG2 cells.
Topics: 3' Untranslated Regions; Base Sequence; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; DNA Primers; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Profiling; Humans; Kinetics; Liver Neoplasms; Male; MAP Kinase Signaling System; MicroRNAs; Polycomb Repressive Complex 2; Protein Kinase C-alpha; Repressor Proteins; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Transcription Factors | 2010 |
Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits matrix metalloproteinase-7 expression and cell invasion of human hepatoma cells.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Line, Tumor; Coumarins; Eleutherococcus; Hep G2 Cells; Humans; Liver Neoplasms; Matrix Metalloproteinase Inhibitors; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Phosphorylation; Phytotherapy; Plant Bark; Plant Extracts; Plant Stems; Tetradecanoylphorbol Acetate | 2010 |
Inhibitory effects of Zuo-Jin-Wan and its alkaloidal ingredients on activator protein 1, nuclear factor-κB, and cellular transformation in HepG2 cells.
Topics: Antineoplastic Agents, Phytogenic; Berberine; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Coptis; Drugs, Chinese Herbal; Evodia; Hep G2 Cells; Humans; Liver Neoplasms; NF-kappa B; Plant Extracts; Quinazolines; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2011 |
SP1 suppresses phorbol 12-myristate 13-acetate induced up-regulation of human regucalcin expression in liver cancer cells.
Topics: Base Sequence; Calcium-Binding Proteins; Chromatin Immunoprecipitation; Gene Expression; Gene Expression Regulation; Genes, Reporter; Hep G2 Cells; Humans; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; Luciferases, Firefly; Molecular Sequence Data; Promoter Regions, Genetic; Protein Binding; Sp1 Transcription Factor; Tetradecanoylphorbol Acetate; Up-Regulation | 2011 |
Induction of lysophosphatidic acid receptor-3 by 12-O-tetradecanoylphorbol-13-acetate stimulates cell migration of rat liver cells.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial Cells; Hepatocytes; Liver; Liver Neoplasms; Rats; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Tetradecanoylphorbol Acetate | 2011 |
Reactive oxygen species-mediated PKC and integrin signaling promotes tumor progression of human hepatoma HepG2.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Movement; Disease Progression; Extracellular Signal-Regulated MAP Kinases; Fluorescent Antibody Technique; Humans; Integrins; Liver Neoplasms; Male; Mice; Mice, Inbred NOD; Mice, SCID; Protein Kinase C-alpha; Reactive Oxygen Species; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2011 |
Shedding of syndecan-1 from human hepatocytes alters very low density lipoprotein clearance.
Topics: Animals; Carcinogens; Cell Line, Tumor; Heparitin Sulfate; Hepatocytes; Humans; Hypertriglyceridemia; Lipopolysaccharides; Lipoproteins, VLDL; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Protein Kinase C; Sepsis; Syndecan-1; Tetradecanoylphorbol Acetate; Triglycerides | 2012 |
The role of PKC isoforms in the inhibition of NF-κB activation by vitamin K2 in human hepatocellular carcinoma cells.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Enzyme Inhibitors; Gene Knockdown Techniques; Humans; Indoles; Liver Neoplasms; Maleimides; NF-kappa B; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Vitamin K 2 | 2012 |
Tamoxifen inhibits migration of estrogen receptor-negative hepatocellular carcinoma cells by blocking the swelling-activated chloride current.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Size; Chloride Channels; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Neoplasm Metastasis; Receptors, Estrogen; RNA, Small Interfering; Tamoxifen; Tetradecanoylphorbol Acetate | 2013 |
Phosphorylation of hepatitis C virus core protein by protein kinase A and protein kinase C.
Topics: Base Sequence; Carcinoma, Hepatocellular; Cell Line; Cyclic AMP-Dependent Protein Kinases; DNA Primers; Enzyme Activation; Humans; Liver; Liver Neoplasms; Microscopy, Confocal; Molecular Sequence Data; Phosphorylation; Polymerase Chain Reaction; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2002 |
Phorbol ester-induced migration of HepG2 cells is accompanied by intensive stress fibre formation, enhanced integrin expression and transient down-regulation of p21-activated kinase 1.
Topics: Actin Cytoskeleton; Carcinogens; Carcinoma, Hepatocellular; Cell Movement; Down-Regulation; Hepatocytes; Humans; Integrin alpha2; Integrin alpha6; Integrin beta1; Liver Neoplasms; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p21-Activated Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Stress Fibers; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2003 |
ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a.
Topics: Activating Transcription Factor 2; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Division; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Depression, Chemical; Electrophoresis, Capillary; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, jun; Genes, p16; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Saponins; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2003 |
Hormonal regulation of the human sterol 27-hydroxylase gene CYP27A1.
Topics: Antineoplastic Agents, Hormonal; Base Sequence; Binding Sites; Carcinogens; Carcinoma, Hepatocellular; Cell Line; Cholestanetriol 26-Monooxygenase; Dexamethasone; Enzyme Repression; Gene Expression Regulation, Enzymologic; Growth Hormone; Humans; Insulin-Like Growth Factor I; Liver Neoplasms; Luciferases; Molecular Sequence Data; Plasmids; Promoter Regions, Genetic; Response Elements; Sequence Deletion; Steroid Hydroxylases; Tetradecanoylphorbol Acetate; Thyroxine; Transcription, Genetic; Transfection | 2003 |
An absolute role of the PKC-dependent NF-kappaB activation for induction of MMP-9 in hepatocellular carcinoma cells.
Topics: Carcinoma, Hepatocellular; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Matrix Metalloproteinase 9; Neoplasm Invasiveness; NF-kappa B; Promoter Regions, Genetic; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transcriptional Activation; Tumor Cells, Cultured | 2003 |
Involvement of phospholipids in the mechanism of insulin action in HEPG2 cells.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Choline; Chromatography, Thin Layer; Diglycerides; Extracellular Space; Humans; Insulin; Lipid Metabolism; Liver Neoplasms; Phosphatidic Acids; Phosphatidylinositol 3-Kinases; Phospholipids; Tetradecanoylphorbol Acetate | 2003 |
Differential regulation of vimentin mRNA by 12-O-tetradecanoylphorbol 13-acetate and all-trans-retinoic acid correlates with motility of Hep 3B human hepatocellular carcinoma cells.
Topics: Carcinoma, Hepatocellular; Cell Movement; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Matrix Metalloproteinases; Neoplasm Metastasis; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator; Vimentin | 2004 |
Effects of the Geiji-Bokryung-Hwan on carrageenan-induced inflammation in mice and cyclooxygenase-2 in hepatoma cells of HepG2 and Hep3B.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Hepatocellular; Carrageenan; Cell Line, Tumor; Cyclooxygenase 2; Dinoprostone; Edema; Female; Hindlimb; Humans; Hydroquinones; Indomethacin; Inflammation; Isoenzymes; Liver Neoplasms; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Phenylbutazone; Plant Extracts; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tyrphostins | 2004 |
Disruption of hepatocellular tight junctions by vascular endothelial growth factor (VEGF): a novel mechanism for tumor invasion.
Topics: Carcinoma in Situ; Carcinoma, Hepatocellular; Cell Line, Tumor; Fluorescent Antibody Technique; Humans; Liver; Liver Neoplasms; Membrane Proteins; Neoplasm Invasiveness; Occludin; Phosphoproteins; Tetradecanoylphorbol Acetate; Tight Junctions; Tissue Distribution; Vascular Endothelial Growth Factor A; Zonula Occludens-1 Protein | 2004 |
Macropinocytosis of polyplexes and recycling of plasmid via the clathrin-dependent pathway impair the transfection efficiency of human hepatocarcinoma cells.
Topics: Biological Transport; Carcinoma, Hepatocellular; Cell Line, Tumor; Chlorpromazine; Clathrin; Endosomes; Fluorescein; Humans; Hydrogen-Ion Concentration; Liver Neoplasms; Luciferases; Nocodazole; Pinocytosis; Plasmids; Polylysine; Tetradecanoylphorbol Acetate; Transfection | 2004 |
Chemopreventive effect of bicyclol on malignant transformation of WB-F344 rat liver epithelial cells and its effect on related signal transduction in vitro.
Topics: Animals; Antineoplastic Agents; Benz(a)Anthracenes; Biphenyl Compounds; Cell Communication; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Colony-Forming Units Assay; Enzyme Induction; Epithelial Cells; I-kappa B Proteins; Liver Neoplasms; Male; Methylcholanthrene; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-KappaB Inhibitor alpha; Protein Kinase C-alpha; Rats; Rats, Inbred F344; Signal Transduction; Tetradecanoylphorbol Acetate | 2006 |
Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine.
Topics: 3' Untranslated Regions; Berberine; Bile Acids and Salts; Carcinogens; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytomegalovirus; Extracellular Signal-Regulated MAP Kinases; Herbal Medicine; Humans; Hypercholesterolemia; In Vitro Techniques; Liver Neoplasms; MAP Kinase Signaling System; Plasmids; Promoter Regions, Genetic; Receptors, LDL; RNA Stability; RNA, Messenger; Tetradecanoylphorbol Acetate | 2005 |
Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2.
Topics: Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Enzyme Activation; Enzyme Inhibitors; Humans; Liver Neoplasms; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C-alpha; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2006 |
Skin tumorigenic potential of aflatoxin B1 in mice.
Topics: Administration, Topical; Aflatoxin B1; Animals; Carcinogens; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Female; Glutathione Transferase; Lipid Peroxidation; Liver; Liver Neoplasms; Mice; Poisons; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2006 |
Transplacental arsenic plus postnatal 12-O-teradecanoyl phorbol-13-acetate exposures associated with hepatocarcinogenesis induce similar aberrant gene expression patterns in male and female mouse liver.
Topics: Administration, Topical; Animals; Arsenic; Female; Gene Expression Profiling; Gene Expression Regulation; Liver; Liver Neoplasms; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred C3H; Oligonucleotide Array Sequence Analysis; Pregnancy; Prenatal Exposure Delayed Effects; Tetradecanoylphorbol Acetate | 2006 |
Interleukin-1beta and tetradecanoylphorbol acetate-induced biosynthesis of tumor necrosis factor alpha in human hepatoma cells involves the transcription factors ATF2 and c-Jun and stress-activated protein kinases.
Topics: Activating Transcription Factor 2; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, Tumor; Dual Specificity Phosphatase 1; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Immediate-Early Proteins; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Kinase 6; p38 Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Phosphorylation; Promoter Regions, Genetic; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Response Elements; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2007 |
Protein kinase C delta regulates the phosphorylation of heat shock protein 27 in human hepatocellular carcinoma.
Topics: Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Heat-Shock Proteins; Humans; Imidazoles; Liver Neoplasms; Mitogen-Activated Protein Kinase 1; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C-delta; Pyridines; RNA, Small Interfering; Tetradecanoylphorbol Acetate | 2007 |
Regulation of activin receptor-interacting protein 2 expression in mouse hepatoma Hepa1-6 cells and its relationship with collagen type IV.
Topics: Activin Receptors, Type II; Activins; Adaptor Proteins, Signal Transducing; Adenylyl Cyclases; Animals; Calcimycin; Calcium; Carcinoma, Hepatocellular; Cell Line, Tumor; Colforsin; Collagen Type IV; Enzyme Activators; Gene Expression Regulation, Neoplastic; Ionophores; Kinetics; Lipopolysaccharides; Liver Neoplasms; Membrane Proteins; Mice; Protein Kinase C; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection | 2007 |
The anti-invasive effect of lucidenic acids isolated from a new Ganoderma lucidum strain.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cholic Acids; Chromatography, High Pressure Liquid; Ganoderma; Humans; Liver Neoplasms; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Terpenes; Tetradecanoylphorbol Acetate; Triterpenes | 2007 |
Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-kappaB and AP-1.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Liver Neoplasms; MAP Kinase Signaling System; Neoplasm Invasiveness; NF-kappa B; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Triterpenes | 2008 |
The transcriptional factor Snail simultaneously triggers cell cycle arrest and migration of human hepatoma HepG2.
Topics: Base Sequence; Cadherins; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Movement; DNA Primers; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Protein Kinase C; Snail Family Transcription Factors; Tetradecanoylphorbol Acetate; Transcription Factors | 2008 |
Various authentic chemoattractants mediating leukocyte adherence inhibition.
Topics: Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Adhesion; Chemotactic Factors; Chemotaxis, Leukocyte; Complement C5; Complement C5a, des-Arginine; Humans; Leukocyte Adherence Inhibition Test; Leukocytes; Leukotriene B4; Liver Neoplasms; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; SRS-A; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1984 |
The involvement of proteases and protease inhibitors in neovascularization.
Topics: Adipose Tissue; Angiogenesis Inducing Agents; Animals; Capillaries; Carcinoma, Hepatocellular; Cartilage; Cattle; Clone Cells; Endothelium; Liver Neoplasms; Microbial Collagenase; Neovascularization, Pathologic; Peptide Hydrolases; Plasminogen Activators; Protease Inhibitors; Retina; Tetradecanoylphorbol Acetate | 1981 |
Can prenatal X-irradiation in mice act as an initiator stimulus in a modified 2-stage Berenblum/Mottram experiment with postnatal promotion with phorbol ester TPA?
Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Cocarcinogenesis; Female; Fetus; Leukemia; Liver Neoplasms; Lung Neoplasms; Maternal-Fetal Exchange; Mice; Ovarian Diseases; Phorbols; Pregnancy; Prostaglandins; Radiation, Ionizing; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; X-Rays | 1980 |
Increased capillary endothelial cell protease activity in response to angiogenic stimuli in vitro.
Topics: Animals; Aorta; Capillaries; Carcinoma, Hepatocellular; Cattle; Cell Division; Endothelium; Humans; Liver Neoplasms; Mice; Microbial Collagenase; Plasminogen Activators; Retina; Tetradecanoylphorbol Acetate; Tissue Extracts | 1983 |
Stimulation of motility in cultured bovine capillary endothelial cells by angiogenic preparations.
Topics: Adrenal Cortex; Animals; Capillaries; Carcinoma, Hepatocellular; Cattle; Cell Line; Cell Movement; Endothelium; Humans; Liver Neoplasms; Mice; Retina; Sarcoma 180; Tetradecanoylphorbol Acetate; Tissue Extracts | 1984 |
Inhibited growth of a reticulum cell sarcoma (M5076) induced in vitro and in vivo by macrophage-activating agents.
Topics: Animals; Cell Differentiation; DNA Replication; Female; Lipopolysaccharides; Liver Neoplasms; Lymphoma, Non-Hodgkin; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Ovarian Neoplasms; Phagocytosis; Tetradecanoylphorbol Acetate | 1984 |
Positive two-stage carcinogenesis in female Sprague-Dawley rats using 7,12-dimethylbenz(a)anthracene (dmba) as initiator and 12-o-tetradecanoylphorbol-13-acetate (tps) as promotor. Results of a pilot study.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benz(a)Anthracenes; Castration; Cocarcinogenesis; Colonic Neoplasms; Female; Intestinal Neoplasms; Liver Neoplasms; Phorbols; Rats; Skin Neoplasms; Stomach; Stomach Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Tumorigenic activity of benzo(e)pyrene derivatives on mouse skin and in newborn mice.
Topics: Animals; Animals, Newborn; Benzopyrenes; Biotransformation; Dihydroxydihydrobenzopyrenes; Female; Liver Neoplasms; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Papilloma; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Effects of various promoters on the induction of hyperplastic nodules in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Hyperplasia; Liver; Liver Neoplasms; Male; Organ Specificity; Rats; Saccharin; Tetradecanoylphorbol Acetate | 1980 |
Hepatoma cell-specific expression of a retrovirally transferred gene is achieved by alpha-fetoprotein but not insulinlike growth factor II regulatory sequences.
Topics: 3T3 Cells; alpha-Fetoproteins; Animals; beta-Galactosidase; Blotting, Northern; Carcinoma, Hepatocellular; DNA; Epidermal Growth Factor; Gene Expression; Gene Transfer Techniques; HeLa Cells; Humans; Insulin-Like Growth Factor II; Liver Neoplasms; Mice; Promoter Regions, Genetic; Rats; Regulatory Sequences, Nucleic Acid; Retroviridae; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
Volume-sensitive chloride channel activity does not depend on endogenous P-glycoprotein.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, Western; Carcinoma, Hepatocellular; Cell Line; Chloride Channels; Daunorubicin; Diglycerides; DNA Primers; Drug Resistance, Multiple; Epithelium; Humans; Intestine, Small; Liver Neoplasms; Membrane Potentials; Molecular Sequence Data; Oligodeoxyribonucleotides; Oligonucleotides, Antisense; Polymerase Chain Reaction; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vincristine | 1995 |
Regulation of the ectopically expressed human glycoprotein alpha-subunit gene in the human hepatoma cell line NPLC.
Topics: Carcinoma, Hepatocellular; Cell Line; Colforsin; Dexamethasone; Gene Expression Regulation, Neoplastic; Glycoprotein Hormones, alpha Subunit; Humans; Hydroxyurea; Kinetics; Liver Neoplasms; Methotrexate; Protein Kinase C; RNA, Messenger; Second Messenger Systems; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured | 1994 |
Distinct signaling pathways mediate phorbol-ester-induced and cytokine-induced inhibition of erythropoietin gene expression.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Carcinoma, Hepatocellular; Cell Hypoxia; Cyclic AMP; Cytokines; Erythropoietin; Gene Expression; Humans; Interleukin-1; Isoenzymes; Kinetics; Liver Neoplasms; Protein Kinase C; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1994 |
Characterization of the promoter region of the human apurinic endonuclease gene (APE).
Topics: Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Line; Chloramphenicol O-Acetyltransferase; Deoxyribonuclease IV (Phage T4-Induced); DNA Primers; DNA Probes; DNA-(Apurinic or Apyrimidinic Site) Lyase; Gene Deletion; Gene Expression; HeLa Cells; Hominidae; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liver Neoplasms; Lyases; Molecular Sequence Data; Oligodeoxyribonucleotides; Promoter Regions, Genetic; Restriction Mapping; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1995 |
Real-time PET analysis of metastatic tumor cell trafficking in vivo and its relation to adhesion properties.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Adhesion; Computer Systems; Endothelium, Vascular; Female; Integrins; Isoquinolines; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplastic Cells, Circulating; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Tomography, Emission-Computed | 1995 |
Mechanism of metallothionein gene regulation by heme-hemopexin. Roles of protein kinase C, reactive oxygen species, and cis-acting elements.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Line; Enzyme Inhibitors; Gene Expression Regulation; Heme; Hemopexin; Hydrogen Peroxide; Isoquinolines; Kinetics; Liver Neoplasms; Metallothionein; Mice; Molecular Sequence Data; Piperazines; Promoter Regions, Genetic; Protein Kinase C; Rabbits; Reactive Oxygen Species; RNA, Messenger; Sequence Deletion; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Xanthine; Xanthines | 1995 |
Cytokine regulation of HIV-1 LTR transactivation in human hepatocellular carcinoma cell lines.
Topics: Amino Acid Sequence; Base Sequence; Carcinoma, Hepatocellular; Chloramphenicol O-Acetyltransferase; Enzyme Activation; Gene Expression Regulation, Enzymologic; Genetic Vectors; HIV Long Terminal Repeat; Humans; Interferon-gamma; Interleukin-1; Interleukin-6; Liver Neoplasms; Molecular Sequence Data; Sequence Deletion; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Up-Regulation | 1995 |
The acute effect of lead acetate on glucocorticoid regulation of tyrosine aminotransferase in hepatoma cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Division; Dexamethasone; Dose-Response Relationship, Drug; Drug Interactions; Environmental Pollutants; Enzyme Induction; Lead; Liver Neoplasms; Organometallic Compounds; Phosphorylation; Protein Biosynthesis; Protein Kinase C; Receptors, Glucocorticoid; Signal Transduction; Tetradecanoylphorbol Acetate; Thymidine; Transcription, Genetic; Tritium; Trypan Blue; Tumor Cells, Cultured; Tyrosine Transaminase | 1995 |
The influence of cytokines on the glycosylation pattern of alpha-1-acid glycoprotein secreted by the HepG2 cell line.
Topics: Carcinoma, Hepatocellular; Cell Line; Culture Media, Conditioned; Cytokines; Glycosylation; Humans; Lipopolysaccharides; Liver Neoplasms; Oligosaccharides; Orosomucoid; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Modulators of protein kinase C inhibit hypoxia-induced erythropoietin production.
Topics: Blotting, Northern; Calcimycin; Carcinoma, Hepatocellular; Diglycerides; DNA; Dose-Response Relationship, Drug; Erythropoietin; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Leucine; Liver Neoplasms; Protein Kinase C; Radioimmunoassay; RNA; Tetradecanoylphorbol Acetate; Tritium; Tumor Cells, Cultured; Uridine | 1993 |
Regulation of the major histocompatibility complex class I mRNA expression by bile acids in cultured human hepatoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bile Acids and Salts; Carcinoma, Hepatocellular; Cell Line; Cell Membrane; Chenodeoxycholic Acid; Cytosol; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Genes, MHC Class I; Histocompatibility Antigens Class I; Humans; Isoquinolines; Kinetics; Liver Neoplasms; Piperazines; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Differential pathways of insulin action upon the hepatitis B surface antigen gene expression and cell proliferation in human hepatoma cells.
Topics: Carcinoma, Hepatocellular; Cell Division; DNA-Binding Proteins; Early Growth Response Protein 1; Gene Expression; Hepatitis B Surface Antigens; Humans; Immediate-Early Proteins; Insulin; Isoenzymes; Liver Neoplasms; Protein Kinase C; Proto-Oncogene Mas; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 1995 |
Decreased expression of hepatocyte nuclear factor 3 alpha during the acute-phase response influences transthyretin gene transcription.
Topics: Animals; Antisense Elements (Genetics); Base Sequence; Carcinoma, Hepatocellular; Chloramphenicol O-Acetyltransferase; DNA Primers; DNA-Binding Proteins; Drosophila; Forkhead Transcription Factors; Gene Expression; Gene Expression Regulation, Neoplastic; Hepatectomy; Hepatocyte Nuclear Factor 3-alpha; Humans; Kinetics; Lipopolysaccharides; Liver; Liver Neoplasms; Mice; Mice, Inbred Strains; Molecular Sequence Data; Mutagenesis, Site-Directed; Nuclear Proteins; Polymerase Chain Reaction; Prealbumin; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; Rats; Recombinant Proteins; RNA Probes; TATA Box; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
[Effect of phorbol ester on protein kinase C and tyrosine protein kinase in human hepatocarcinoma cell line].
Topics: Alkaline Phosphatase; Carcinoma, Hepatocellular; Cell Division; gamma-Glutamyltransferase; Humans; Liver Neoplasms; Protein Kinase C; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Characterization of the gap junction protein, connexin45.
Topics: Animals; Antibody Specificity; Carcinoma, Hepatocellular; Cell Line; Cell Line, Transformed; Connexin 43; Connexins; Cricetinae; Fluorescent Antibody Technique; Gap Junctions; Humans; Kidney; Liver Neoplasms; Membrane Proteins; Mice; Muscle, Smooth, Vascular; Myocardium; Neuroblastoma; Phosphorylation; Precipitin Tests; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Human thyroxine-binding globulin gene: complete sequence and transcriptional regulation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Chlorocebus aethiops; CHO Cells; Consensus Sequence; Cricetinae; Dexamethasone; DNA-Binding Proteins; DNA, Complementary; Estradiol; Fibroblasts; Gene Expression Regulation; Genes; Hepatoblastoma; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; Humans; Liver; Liver Neoplasms; Molecular Sequence Data; Multigene Family; Neoplasm Proteins; Niacin; Nuclear Proteins; Organ Specificity; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Sequence Deletion; Tetradecanoylphorbol Acetate; Thyroxine-Binding Proteins; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Retinoic acid receptors and retinoid X receptor-alpha down-regulate the transforming growth factor-beta 1 promoter by antagonizing AP-1 activity.
Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Carcinoma, Hepatocellular; Collagenases; Fibrosarcoma; Gene Expression Regulation, Neoplastic; Genes, fos; Humans; Liver Neoplasms; Molecular Sequence Data; Mutagenesis, Site-Directed; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Tetradecanoylphorbol Acetate; Transcription Factors; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured | 1993 |
Regulation of HIV-1 LTR trans-activating activities in two different human hepatocellular carcinoma cell lines.
Topics: Base Sequence; Carcinoma, Hepatocellular; Cell Differentiation; Chloramphenicol O-Acetyltransferase; Gene Expression Regulation, Neoplastic; HIV Enhancer; HIV Long Terminal Repeat; HIV-1; Humans; Liver Neoplasms; Molecular Sequence Data; NF-kappa B; Plasmids; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Repressor Proteins; Sp1 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Up-Regulation | 1993 |
Plasminogen activator inhibitor-1 synthesis in the human hepatoma cell line Hep G2. Metformin inhibits the stimulating effect of insulin.
Topics: Acetates; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cells, Cultured; DNA Probes; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Humans; Insulin; Insulin Antagonists; Interleukin-10; Kinetics; Liver Neoplasms; Metformin; Plasminogen Activator Inhibitor 1; Receptor, Insulin; Recombinant Proteins; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Umbilical Veins | 1993 |
Regulation of low-density-lipoprotein receptors in the human hepatoma cell line Hep G2. Effect of phorbol 12-myristate 13-acetate and low-density lipoprotein.
Topics: Animals; Carcinoma, Hepatocellular; Humans; Lipoproteins, LDL; Liver Neoplasms; Male; Rats; Rats, Wistar; Receptors, LDL; Sterol O-Acyltransferase; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Characterization of a DNA-protein interaction at the antioxidant responsive element and induction by 12-O-tetradecanoylphorbol 13-acetate.
Topics: Animals; Antioxidants; Base Sequence; Carcinoma, Hepatocellular; Cell Nucleus; Deoxyribonuclease I; DNA; Gene Expression Regulation, Enzymologic; Genes, fos; Genes, jun; HeLa Cells; Humans; Hydrogen Peroxide; Liver Neoplasms; Molecular Sequence Data; NAD(P)H Dehydrogenase (Quinone); Nuclear Proteins; Oligodeoxyribonucleotides; Protein Biosynthesis; Rats; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1993 |
Characterization and regulation of corticotropin-releasing factor in the human hepatoma NPLC-KC cell line.
Topics: Adenylyl Cyclases; Adrenocorticotropic Hormone; Animals; Carcinoma, Hepatocellular; Colforsin; Corticotropin-Releasing Hormone; Culture Media, Conditioned; Dexamethasone; Humans; Interleukin-1; Liver Neoplasms; Pituitary Gland, Anterior; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Differential regulation of distinct types of gap junction channels by similar phosphorylating conditions.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Base Sequence; Carcinoma, Hepatocellular; Cell Communication; Connexin 26; Connexins; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; DNA Primers; Enzyme Inhibitors; Gap Junctions; Gene Expression; Homeostasis; Humans; Liver Neoplasms; Membrane Potentials; Molecular Sequence Data; Phosphorylation; Polymerase Chain Reaction; Protein Kinase C; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1995 |
TCDD-inducible plasminogen activator inhibitor type 2 (PAI-2) in human hepatocytes, HepG2 and monocytic U937 cells.
Topics: Aryl Hydrocarbon Receptor Nuclear Translocator; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; Dactinomycin; DNA-Binding Proteins; Humans; Liver; Liver Neoplasms; Plasminogen Activator Inhibitor 2; Polychlorinated Dibenzodioxins; Protein Synthesis Inhibitors; Receptors, Aryl Hydrocarbon; RNA, Messenger; Serine Proteinase Inhibitors; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factors; Tumor Cells, Cultured | 1996 |
Differential mechanisms targeting type 1 plasminogen activator inhibitor and vitronectin into the storage granules of a human megakaryocytic cell line.
Topics: Base Sequence; Biological Transport; Carcinoma, Hepatocellular; Cell Differentiation; Cytoplasmic Granules; Endocytosis; Humans; Leukemia, Megakaryoblastic, Acute; Liver Neoplasms; Megakaryocytes; Microscopy, Confocal; Molecular Sequence Data; Neoplasm Proteins; Plasminogen Activator Inhibitor 1; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vacuoles; Vitronectin | 1996 |
Effect of all-trans-retinoic acid and phorbol 12-myristate 13-acetate on the activity of human hepatocellular carcinoma cell-surface beta-1,4-galactosyltransferase.
Topics: Aminopyridines; Carbohydrate Conformation; Carbohydrate Sequence; Carcinoma, Hepatocellular; Cell Differentiation; Cell Division; Cell Line; Cell Membrane; Humans; Kinetics; Liver Neoplasms; Molecular Sequence Data; N-Acetyllactosamine Synthase; Oligosaccharides; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1996 |
Lead may affect glucocorticoid signal transduction in cultured hepatoma cells through inhibition of protein kinase C.
Topics: Animals; Blotting, Western; Calcium Chloride; Carcinoma, Hepatocellular; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Genistein; Glucocorticoids; Isoenzymes; Isoflavones; Lead; Liver Neoplasms; Organometallic Compounds; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine Transaminase | 1997 |
Anti-tumor promoting activities of lantadenes on mouse skin tumors and mouse hepatic tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Diethylnitrosamine; Female; Hyperplasia; Liver Neoplasms; Mice; Mice, Inbred ICR; Oleanolic Acid; Papilloma; Phenobarbital; Plants, Medicinal; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Characterization of the "estrogenicity" of tamoxifen and raloxifene in HepG2 cells: regulation of gene expression from an ERE controlled reporter vector versus regulation of the endogenous SHBG and PS2 genes.
Topics: Alkaline Phosphatase; Carcinoma, Hepatocellular; Clone Cells; Estradiol; Estradiol Congeners; Estrogen Antagonists; Ethinyl Estradiol; Female; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Kinetics; Liver Neoplasms; Piperidines; Placenta; Pregnancy; Protein Biosynthesis; Proteins; Raloxifene Hydrochloride; Receptors, Estrogen; Recombinant Fusion Proteins; Sex Hormone-Binding Globulin; Tamoxifen; Tetradecanoylphorbol Acetate; Trefoil Factor-1; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1997 |
The HMC-1 human mast cell line expresses the hepatocyte growth factor receptor c-met.
Topics: Calcimycin; Hepatoblastoma; Humans; Leukemia, Mast-Cell; Liver Neoplasms; Proto-Oncogene Mas; Proto-Oncogene Proteins c-met; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1997 |
Protein kinase C activity is required for aryl hydrocarbon receptor pathway-mediated signal transduction.
Topics: Alkaloids; Aryl Hydrocarbon Receptor Nuclear Translocator; Benzophenanthridines; Carcinoma, Hepatocellular; Cytosol; Dimerization; DNA-Binding Proteins; Enzyme Inhibitors; Genetic Vectors; HeLa Cells; Humans; Indoles; Liver Neoplasms; Maleimides; Phenanthridines; Polychlorinated Dibenzodioxins; Protein Binding; Protein Kinase C; Receptors, Aryl Hydrocarbon; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factors; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 1998 |
Phosphatidylinositol 3-kinase is required for the regulation of hepatitis B surface antigen production and mitogen-activated protein kinase activation by insulin but not by TPA.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Hepatocellular; Enzyme Activation; Enzyme Inhibitors; Hepatitis B Surface Antigens; Humans; Insulin; Liver Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1998 |
Signaling pathways in the induction of c-fos and c-jun proto-oncogenes by 3-methylcholanthrene.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Hepatocellular; Chloramphenicol O-Acetyltransferase; Enzyme Activation; Gene Expression Regulation; Genes, fos; Genes, jun; Humans; Liver Neoplasms; Methylcholanthrene; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Recombinant Fusion Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1997 |
Differential effects of phorbol ester on growth and protein kinase C isoenzyme regulation in human hepatoma Hep3B cells.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Indirect; Humans; Isoenzymes; Liver Neoplasms; Mitogens; Protein Kinase C; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Effect of phorbol 12-myristate-13-acetate on cell adhesion in SMMC-7721 human hepatocellular carcinoma cell line and its mechanism.
Topics: Blotting, Northern; Carcinogens; Carcinoma, Hepatocellular; Cell Adhesion; Fibronectins; Humans; Integrins; Liver Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Transcriptional regulation of human transcription factor IIB in SMMC-7721 human hepatocellular carcinoma cells by all-trans-retinoic acid and phorbol 12-myristate 13-acetate.
Topics: Antineoplastic Agents; Carcinogens; Carcinoma, Hepatocellular; DNA Primers; Humans; Liver Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA-Directed DNA Polymerase; Tetradecanoylphorbol Acetate; Transcription Factor TFIIB; Transcription Factors; Transcription, Genetic; Tretinoin; Tumor Cells, Cultured | 1998 |
On the role of c-Jun in the induction of PAI-1 gene expression by phorbol ester, serum, and IL-1alpha in HepG2 cells.
Topics: Binding Sites; Blood; Blotting, Northern; Carcinoma, Hepatocellular; Enzyme Inhibitors; Gene Expression; Genistein; Humans; Immunosorbent Techniques; Interleukin-1; Liver; Liver Neoplasms; Plasminogen Activator Inhibitor 1; Promoter Regions, Genetic; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-jun; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vanadates | 1999 |
Bile acids modulate the interferon signalling pathway.
Topics: 2',5'-Oligoadenylate Synthetase; Animals; Antiviral Agents; Bile Acids and Salts; Carcinoma, Hepatocellular; Carrier Proteins; Cell Survival; Chenodeoxycholic Acid; CHO Cells; Cricetinae; DNA Fragmentation; Gene Expression Regulation; GTP-Binding Proteins; Humans; Interferon alpha-2; Interferon-alpha; Kinetics; Liver Neoplasms; Models, Biological; Myxovirus Resistance Proteins; Organic Anion Transporters, Sodium-Dependent; Promoter Regions, Genetic; Proteins; Recombinant Proteins; Signal Transduction; Symporters; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1999 |
Enhanced polymorphonuclear neutrophil-mediated endothelial cell injury and its relation to high surgical mortality rate in cirrhotic patients.
Topics: Adult; Aged; Carcinogens; Carcinoma; Carcinoma, Hepatocellular; Cell Communication; Cells, Cultured; Endothelium, Vascular; Female; Hepatectomy; Humans; Incidence; L-Lactate Dehydrogenase; Leukocyte Elastase; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Neutrophils; Postoperative Complications; Survival Rate; Tetradecanoylphorbol Acetate; Thrombomodulin | 1999 |
Hypoosmolarity influences the activity of transcription factor NF-kappaB in rat H4IIE hepatoma cells.
Topics: Animals; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspases; Enzyme Inhibitors; Liver Neoplasms; NF-kappa B; Osmolar Concentration; Phosphoinositide-3 Kinase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured | 2000 |
Phosphatidylinositol 3-kinase contributes to Erk1/Erk2 MAP kinase activation associated with hepatocyte growth factor-induced cell scattering.
Topics: Carcinoma, Hepatocellular; Cell Movement; Chromones; Cycloheximide; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Liver Neoplasms; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Ubiquitin-Protein Ligases | 1999 |
Amino acid uptake and regulation in multicellular hepatoma spheroids.
Topics: Amino Acid Transport System ASC; Amino Acids; Arginine; beta-Alanine; Biological Transport; Blotting, Northern; Carcinogens; Carcinoma, Hepatocellular; Carrier Proteins; Cell Culture Techniques; Cell Division; Gene Expression; Glutamine; Humans; Leucine; Liver Neoplasms; Microscopy, Electron, Scanning; Minor Histocompatibility Antigens; Protein Kinase C; Receptors, Virus; RNA, Messenger; Sodium; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Gene transfer to hepatocellular carcinoma: transduction efficacy and transgene expression kinetics by using retroviral and lentiviral vectors.
Topics: Azacitidine; Carcinoma, Hepatocellular; Cell Survival; Dexamethasone; Flow Cytometry; Genetic Vectors; Green Fluorescent Proteins; HIV; Humans; Interleukin-6; Ionomycin; Kinetics; Leukemia Virus, Murine; Liver Neoplasms; Luminescent Proteins; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transduction, Genetic; Transgenes; Tumor Cells, Cultured | 2000 |
The induction of the human hepatic CYP2E1 gene by interleukin 4 is transcriptional and regulated by protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2E1; Gene Expression Regulation, Enzymologic; Hepatocytes; Humans; Interleukin-4; Kinetics; Liver; Liver Neoplasms; Protein Biosynthesis; Protein Kinase C; RNA, Messenger; STAT6 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription, Genetic; Tumor Cells, Cultured | 2000 |
LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Anticholesteremic Agents; Apolipoproteins E; Arteriosclerosis; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters; Carcinoma, Hepatocellular; Cell Differentiation; Cells, Cultured; Cholesterol; Diet, Atherogenic; Dimerization; DNA-Binding Proteins; Enhancer Elements, Genetic; Gene Expression Regulation; Humans; Hydrocarbons, Fluorinated; Hydroxycholesterols; Ligands; Lipids; Liver Neoplasms; Liver X Receptors; Lovastatin; Macrophages, Peritoneal; Male; Mevalonic Acid; Mice; Mice, Knockout; Organic Chemicals; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Recombinant Fusion Proteins; Retinoid X Receptors; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 2001 |
Expression of thrombospondin-1 in human hepatocarcinoma cell lines and its regulation by transcription factor Jun/AP-1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Binding Sites; Blotting, Northern; Blotting, Western; Carcinogens; Carcinoma, Hepatocellular; Cell Nucleus; Cell Survival; Enzyme Inhibitors; Gene Deletion; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Liver Neoplasms; Luciferases; Models, Genetic; Mutation; Plasmids; Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogene Proteins c-jun; Tetradecanoylphorbol Acetate; Thrombospondin 1; Time Factors; Transcription Factor AP-1; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Up-Regulation | 2001 |
Regulation of differentiation- and proliferation-inducers on Lewis antigens, alpha-fucosyltransferase and metastatic potential in hepatocarcinoma cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Adhesion; Cell Differentiation; Cell Division; Cell Movement; Epidermal Growth Factor; Fucosyltransferases; Humans; Lewis Blood Group Antigens; Lewis X Antigen; Liver Neoplasms; Neoplasm Metastasis; Phenotype; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 2001 |
The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Antigens, CD; Binding Sites; Carcinoma, Hepatocellular; Cell Line; Cytokine Receptor gp130; DNA Primers; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Granulocyte Colony-Stimulating Factor; Humans; Interferon-gamma; Interleukin-6; Liver Neoplasms; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Protein Kinases; Recombinant Fusion Proteins; Recombinant Proteins; Serine; Signal Transduction; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2001 |
Involvement of p-15(INK4b) and p-16(INK4a) gene expression in saikosaponin a and TPA-induced growth inhibition of HepG2 cells.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Carrier Proteins; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Liver Neoplasms; Oleanolic Acid; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sapogenins; Saponins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2001 |
Differential regulation of activator protein 1 activity by glycyrrhizin.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cell Survival; Chlorocebus aethiops; Dose-Response Relationship, Drug; Gene Expression Regulation; Glycyrrhizic Acid; Humans; Liver Neoplasms; Promoter Regions, Genetic; Response Elements; TATA Box; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transfection; Tumor Cells, Cultured; Vero Cells | 2002 |
Tumorigenicity of the dihydrodiols of dibenzo(a,h)anthracene on mouse skin and in newborn mice.
Topics: Animals; Animals, Newborn; Benz(a)Anthracenes; Carcinogens; Female; Liver Neoplasms; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Pregnancy; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1979 |
Tumorigenic activity of 3-methylcholanthrene metabolites on mouse skin and in newborn mice.
Topics: Administration, Topical; Animals; Animals, Newborn; Carcinogens; Cocarcinogenesis; Drug Administration Schedule; Female; Injections, Intraperitoneal; Liver Neoplasms; Lung Neoplasms; Male; Methylcholanthrene; Mice; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1979 |
Visualization of oxidative processes at the cellular level during neutrophil-mediated cytotoxicity against a human hepatoma cell line, HCC-M.
Topics: Carcinoma, Hepatocellular; Fluoresceins; Humans; Liver Neoplasms; Luminescent Measurements; Neutrophils; Oxidation-Reduction; Picibanil; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Phorbol ester inhibits erythropoietin production in human hepatoma cells (Hep G2).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Carcinoma, Hepatocellular; Erythropoietin; Humans; Isoquinolines; Liver Neoplasms; Oxygen; Piperazines; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tissue Distribution; Tumor Cells, Cultured | 1992 |
Transcriptional repression of interleukin-6 gene by adenoviral E1A proteins.
Topics: Adenovirus E1A Proteins; Binding Sites; Bucladesine; Carcinoma, Hepatocellular; Chloramphenicol O-Acetyltransferase; Cyclic AMP; DNA; Gene Expression; HeLa Cells; Humans; Interleukin-1; Interleukin-6; Liver Neoplasms; NF-kappa B; Oligodeoxyribonucleotides; Promoter Regions, Genetic; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Thymidine Kinase; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1992 |
Possible involvement of protein kinase C and calcium in GSH efflux from Hep G2 cells.
Topics: Adenosine Triphosphate; Alkaloids; Calcium; Carcinoma, Hepatocellular; Glutathione; Humans; Liver Neoplasms; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Verapamil | 1992 |
Role of protein kinase-C in regulation of insulin-like growth factor-binding protein-1 production by HepG2 cells.
Topics: Carcinoma, Hepatocellular; Carrier Proteins; Cell Count; Dose-Response Relationship, Drug; Drug Interactions; Humans; Insulin; Insulin-Like Growth Factor Binding Protein 1; Liver Neoplasms; Protein Kinase C; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1992 |
Multiple insulin-responsive elements regulate transcription of the GAPDH gene.
Topics: Base Sequence; Chloramphenicol O-Acetyltransferase; DNA-Binding Proteins; Enzyme Induction; Gene Expression Regulation, Enzymologic; Glyceraldehyde-3-Phosphate Dehydrogenases; Insulin; Liver Neoplasms; Molecular Sequence Data; Oncogene Proteins; Recombinant Proteins; Regulatory Sequences, Nucleic Acid; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Potent preventive action of alpha-carotene against carcinogenesis: spontaneous liver carcinogenesis and promoting stage of lung and skin carcinogenesis in mice are suppressed more effectively by alpha-carotene than by beta-carotene.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; beta Carotene; Carotenoids; Drug Screening Assays, Antitumor; Humans; Liver Neoplasms; Lung Neoplasms; Male; Mice; Mice, Inbred C3H; Ornithine Decarboxylase; Papilloma; Skin Neoplasms; Specific Pathogen-Free Organisms; Tetradecanoylphorbol Acetate | 1992 |
The exposure of carcinogen-initiated primary neonatal rat hepatocytes to tumor promoters modulates both the transcripts and the enzymatic activity of nuclear poly(ADP-ribose) polymerase.
Topics: Animals; Animals, Newborn; Benzamides; Calcium; Cell Cycle; Cell Nucleus; Cells, Cultured; Dimethylnitrosamine; DNA Replication; Epidermal Growth Factor; Female; Kinetics; Liver; Liver Neoplasms; Maternal-Fetal Exchange; Mutagenesis; Phenobarbital; Poly(ADP-ribose) Polymerases; Precancerous Conditions; Pregnancy; Rats; Rats, Inbred Strains; Sodium Fluoride; Tetradecanoylphorbol Acetate; Thymidine; Transcription, Genetic | 1992 |
Effects of glucocorticoid on corticotropin-releasing hormone gene regulation by second messenger pathways in NPLC and AtT-20 cells.
Topics: Animals; Colforsin; Corticotropin-Releasing Hormone; Cycloheximide; Dexamethasone; Gene Expression Regulation; Glucocorticoids; Humans; Liver Neoplasms; Mice; Protein Kinases; RNA, Messenger; Second Messenger Systems; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Regulation of beta-actin gene transcription by insulin and phorbol esters.
Topics: Actins; Animals; Dose-Response Relationship, Drug; Gene Expression Regulation; In Vitro Techniques; Insulin; Liver Neoplasms; Liver Neoplasms, Experimental; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic; Tubulin; Tumor Cells, Cultured | 1992 |
Signal transduction pathways in the induction of HLA class I antigen expression on Huh 6 cells by interferon-gamma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Calmodulin; Carcinoma, Hepatocellular; Cell Line; Cyclic CMP; Histocompatibility Antigens Class I; Humans; Interferon-gamma; Isoquinolines; Liver Neoplasms; Piperazines; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
The cytokine-protease connection: identification of a 96-kD THP-1 gelatinase and regulation by interleukin-1 and cytokine inducers.
Topics: Amino Acid Sequence; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line; Concanavalin A; Gelatinases; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Interleukin-1; Kinetics; Leukemia, Monocytic, Acute; Lipopolysaccharides; Liver Neoplasms; Molecular Sequence Data; Molecular Weight; Pepsin A; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1991 |
Different induction of two plasminogen activator inhibitor 1 mRNA species by phorbol ester in human hepatoma cells.
Topics: Blotting, Northern; Carcinoma, Hepatocellular; Cycloheximide; Enzyme Activation; Humans; Liver Neoplasms; Plasminogen Inactivators; Protein Biosynthesis; Protein Kinase C; RNA Processing, Post-Transcriptional; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1991 |
Inhibition of erythropoietin production by phorbol ester is associated with down-regulation of protein kinase C-alpha isoenzyme in hepatoma cells.
Topics: Alkaloids; Carcinoma, Hepatocellular; Erythropoietin; Humans; Isoenzymes; Kinetics; Liver Neoplasms; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Modulation of the constitutive gene expression of the 55 kD tumor necrosis factor receptor in hematopoietic cells.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Carcinoma, Hepatocellular; Colforsin; Gene Expression Regulation; Humans; Leukemia, Promyelocytic, Acute; Leukocytes, Mononuclear; Liver Neoplasms; Molecular Weight; Neutrophils; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Cell Surface; Receptors, Tumor Necrosis Factor; Recombinant Proteins; Reference Values; RNA; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1990 |
Cytokine messenger RNA stability is enhanced in tumor cells.
Topics: Adenocarcinoma; Base Sequence; Carcinoma, Hepatocellular; Cell Line; Cytokines; Gene Expression Regulation, Neoplastic; Glioma; Globins; Granulocyte-Macrophage Colony-Stimulating Factor; Kinetics; Liver Neoplasms; Lung Neoplasms; Molecular Sequence Data; Pancreatic Neoplasms; RNA, Messenger; Tetradecanoylphorbol Acetate; Transfection | 1991 |
Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase by ph
Topics: Amino Acid Sequence; Base Sequence; Carcinoma, Hepatocellular; Cycloheximide; Dimethylallyltranstransferase; DNA; DNA Probes; Gene Expression Regulation; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Synthase; Liver Neoplasms; Molecular Sequence Data; Nucleic Acid Hybridization; Oxo-Acid-Lyases; Placenta; Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Transferases; Tumor Cells, Cultured | 1990 |
Effects of phorbol ester on cell growth inhibition by transforming growth factor beta 1 in human hepatoma cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Carcinoma, Hepatocellular; Cell Division; DNA; Epithelial Cells; Growth Inhibitors; Humans; In Vitro Techniques; Isoquinolines; Liver Neoplasms; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tumor Cells, Cultured | 1990 |
Human hepatoma cells produce an 85 kDa gelatinase regulated by phorbol 12-myristate 13-acetate.
Topics: Carcinoma, Hepatocellular; Cell Survival; Enzyme Activation; Gelatinases; Humans; Hydrogen-Ion Concentration; Liver Neoplasms; Metalloendopeptidases; Molecular Weight; Pepsin A; Protease Inhibitors; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Phorbol ester modulates interleukin 6- and interleukin 1-regulated expression of acute phase plasma proteins in hepatoma cells.
Topics: Acute-Phase Proteins; Animals; Carcinoma, Hepatocellular; Cell Line; Ethers; Humans; Interleukin-1; Interleukin-6; Interleukins; Ionomycin; Kinetics; Liver Neoplasms; Liver Neoplasms, Experimental; Rats; Recombinant Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1988 |
Binding of metastatic colon carcinoma cells to liver macrophages.
Topics: Animals; Carcinoma; Cell Adhesion; Cell Line; Colchicine; Colonic Neoplasms; Cytochalasin B; Cytotoxicity, Immunologic; Egtazic Acid; Kupffer Cells; Liver Neoplasms; Macrophages; Male; Monosaccharides; Peritoneal Cavity; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Trypsin | 1989 |
H2O2 potentiates phosphorylation of novel putative substrates for the insulin receptor kinase in intact Fao cells.
Topics: Bucladesine; Carcinoma, Hepatocellular; Cell Line; Humans; Hydrogen Peroxide; Insulin; Kinetics; Liver Neoplasms; Phosphorylation; Protein-Tyrosine Kinases; Receptor, Insulin; Tetradecanoylphorbol Acetate | 1989 |
Secretion of Mr 46,000 protein from human hepatoma cells treated with tumor promotors is regulated by c-myc gene expression.
Topics: Carcinoma, Hepatocellular; Cell Division; Gene Expression Regulation; Humans; Liver Neoplasms; Molecular Weight; Neoplasm Proteins; Proto-Oncogenes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Tumor necrosis factor-alpha induces a kappa B sequence-specific DNA-binding protein in human hepatoblastoma HepG2 cells.
Topics: Base Sequence; Carcinoma, Hepatocellular; Chloramphenicol O-Acetyltransferase; DNA; Enhancer Elements, Genetic; Gene Expression; Gene Products, tat; Genes, Viral; HIV-1; Humans; Liver Neoplasms; Molecular Sequence Data; NF-kappa B; Plasmids; Recombinant Proteins; Repetitive Sequences, Nucleic Acid; tat Gene Products, Human Immunodeficiency Virus; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription Factors; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1989 |
c-myc gene expression in human cells is controlled by glucose.
Topics: 3-O-Methylglucose; Animals; Carcinoma, Hepatocellular; Cattle; Dexamethasone; Fetal Blood; Fructose; Gene Expression Regulation; Glucose; Humans; Liver Neoplasms; Lymphocytes; Methylglucosides; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Proto-Oncogenes; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Hepatic tumor-promoting chlorinated hydrocarbons stimulate protein kinase C activity.
Topics: Animals; Brain; Calcium; Carcinogens; Chlordan; Female; Hydrocarbons, Fluorinated; Liver; Liver Neoplasms; Mice; Protein Kinase C; Skin; Tetradecanoylphorbol Acetate | 1989 |
Prolactin is a tumor promoter in rat liver.
Topics: Animals; Enzyme Induction; Female; gamma-Glutamyltransferase; Hepatomegaly; Liver Neoplasms; Ornithine Decarboxylase; Plasminogen Activators; Prolactin; Rats; Rats, Inbred Strains; Sheep; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Control of gastrin release in cultured gastrinoma-derived G cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adult; Cells, Cultured; Chromaffin System; Colforsin; Enterochromaffin Cells; Female; Gastrins; Humans; Immunohistochemistry; Liver Neoplasms; Phorbol Esters; Radioimmunoassay; Secretin; Somatostatin; Tetradecanoylphorbol Acetate; Zollinger-Ellison Syndrome | 1988 |
Production of latent collagenase by human umbilical vein endothelial cells in response to angiogenic preparations.
Topics: Adipose Tissue; Angiogenesis Inducing Agents; Blood; Carcinoma, Hepatocellular; Cell Survival; Cells, Cultured; Endothelium; Enzyme Induction; Epidermal Growth Factor; Fibroblast Growth Factors; Growth Substances; Humans; Liver Neoplasms; Microbial Collagenase; Mitogens; Plasminogen Activators; Retina; Tetradecanoylphorbol Acetate; Tissue Extracts; Umbilical Veins | 1985 |
Induced secretion of a Mr 46,000 protein by cultured human hepatoma cells treated with tumor promoters.
Topics: Carcinogens; Carcinoma, Hepatocellular; Cells, Cultured; Dactinomycin; Humans; Liver Neoplasms; Molecular Weight; Neoplasm Proteins; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1985 |
Collagenase and plasminogen activator production by blood vessel-associated cells in response to angiogenic preparations.
Topics: Animals; Blood Vessels; Carcinoma, Hepatocellular; Cattle; Cells, Cultured; Fibroblasts; Humans; Liver Neoplasms; Microbial Collagenase; Plasminogen Activators; Tetradecanoylphorbol Acetate | 1985 |
Phosphorylation of receptors for insulin and insulin-like growth factor I. Effects of hormones and phorbol esters.
Topics: Carcinoma, Hepatocellular; Cell Line; Electrophoresis, Polyacrylamide Gel; Humans; Liver Neoplasms; Phorbol Esters; Phosphoproteins; Phosphorylation; Protein Kinase C; Receptor, Insulin; Receptors, Cell Surface; Receptors, Somatomedin; Tetradecanoylphorbol Acetate; Trypsin | 1986 |
Effects of tumour promoters on metabolic cooperation between human hepatoma cells.
Topics: Carcinogens; Carcinoma, Hepatocellular; Cell Communication; Cell Line; Humans; Hypoxanthine Phosphoribosyltransferase; Liver Neoplasms; Phenobarbital; Tetradecanoylphorbol Acetate | 1986 |