tetradecanoylphorbol acetate has been researched along with Cancer of Colon in 165 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (19.39) | 18.7374 |
| 1990's | 87 (52.73) | 18.2507 |
| 2000's | 37 (22.42) | 29.6817 |
| 2010's | 8 (4.85) | 24.3611 |
| 2020's | 1 (0.61) | 2.80 |
| Authors | Studies |
|---|---|
| Aslan, M; Çeker, T; Köksoy, S; Yilmaz, Ç | 1 |
| Huang, JA; Liu, SQ; Qin, MB; Su, YJ; Tang, GD | 1 |
| Huseby, NE; Moens, U; Pandur, S; Ravuri, C | 1 |
| Anto, RJ; Bava, SV; Narayanan, SS; Nath, LR; Radhakrishnan, EK; Soniya, EV; Thulasidasan, AK | 1 |
| Gao, D; Ji, C; Li, P; Li, X; Qu, X; Shao, Q; Song, B; Sun, J; Wang, Q; Zhao, P | 1 |
| Cho, HJ; Ha, BG; Lim, YB; Park, JE; Shon, YH | 1 |
| Jang, TJ; Jeon, KH; Jung, KH | 1 |
| Bae, HS; Han, SI; Jeon, HM; Ju, MK; Kang, HS; Kim, CH; Lee, SY; Lim, SC; Park, HG | 1 |
| Clarke, M; Das, S; Huels, D; Jamieson, T; Jung, A; Neumann, J; Nibbs, RJ; Olson, MF; Samuel, MS; Sansom, OJ; Steele, CW | 1 |
| Ahn, JB; Bae, SH; Bae, SK; Chung, HC; Hwang, JW; Lim, SM; Rha, SY; Roh, JK; Shin, SJ | 1 |
| Ho, YS; Lee, WS; Liang, YC; Lin, SY; Pan, S; Tsai, SH | 1 |
| Furuse, M; Ohmori, M; Okumura, K; Sasazuki, T; Shirasawa, S | 1 |
| Fan, XM; Jiang, SH; Jiang, Xh; Kung, HF; Lam, SK; Lin, MC; Wong, BC | 1 |
| Arango, D; Augenlicht, LH; Heerdt, BG; Mariadason, JM; Wilson, AJ | 1 |
| Alrefai, WA; Dudeja, PK; Gill, R; Hadjiagapiou, C; Mansour, F; Ramaswamy, K; Saksena, S; Tyagi, S | 1 |
| Evers, BM; Wang, Q; Wang, X | 1 |
| Dosescu, J; Moin, K; Sameni, M; Sloane, BF | 1 |
| Ho, CT; Hong, J; Hou, Z; Huang, MT; Lambert, JD; Rosen, RT; Ryu, JH; Sang, S; Stark, RE; Tian, S; Yang, CS | 1 |
| Evers, BM; Hu, W; Wang, Q; Wang, X | 1 |
| Baba, M; Kai, H; Koine, T; Okuyama, T | 1 |
| Kim, HY; Kim, JS; Kim, YK; Sung, MK; Yu, R | 1 |
| Fresno, M; Grau, R; Iñiguez, MA | 1 |
| Eggo, MC; Langman, MJ; Lewis, AE; Susarla, R; Wong, BC | 1 |
| Duque, J; Fresno, M; Iñiguez, MA | 1 |
| Bosia, A; Costamagna, C; Ghigo, D; Miraglia, E; Riganti, C; Viarisio, D | 1 |
| Kuniyasu, H; Ohmori, H; Sasahira, T; Sasaki, T; Sone, S; Yano, S | 1 |
| Bovey, R; Meyer, E; Stamenkovic, I; Vollmer, JY | 1 |
| Laegreid, A; Thommesen, L | 1 |
| Hao, XS; Li, Q; Sun, BC; Xu, T | 1 |
| Kelleher, D; Long, A; Looby, E; Shah, SA; Volkov, Y | 1 |
| Nam, KS; Shon, YH | 1 |
| Blasi, F; Díaz, VM; Hurtado, M; Kort, EJ; Paciucci, R; Resnati, M; Thomson, T | 1 |
| Baik, HW; Ha, J; Hwang, JT; Kim, YM; Lee, SK; Park, OJ; Surh, YJ | 1 |
| Bialkowska, A; Chanchevalap, S; Katz, JP; Rusovici, R; Shim, H; Yang, VW; Yun, CC; Zhang, H | 1 |
| Ban, JO; Chung, YB; Hong, JT; Hwang, BY; Jeong, HS; Kim, DJ; Kim, TM; Lee, US; Oh, KW; Woo, KS; Yuk, DY | 1 |
| Hong, JT; Jung, JK; Lee, BS; Lee, SY; Moon, DC; Song, HS; Yoon, DY; Yuk, DY | 1 |
| Akamatsu, N; Miyaki, M; Ono, T; Rokutanda, M; Sasaki, M; Tonomura, A; Utsunomiya, J; Yoshikura, H | 1 |
| Friedman, E; Urmacher, C; Winawer, S | 1 |
| Csuka, O; Sugár, J; Szentirmay, Z | 1 |
| Kopelovich, L | 5 |
| Gainer, HS; Kinsella, AR | 1 |
| Goerttler, K; Hesse, B; Loehrke, H; Schweizer, J | 1 |
| Friedman, EA | 4 |
| Friedman, EA; Steinberg, M | 1 |
| Bias, NE; Kopelovich, L | 1 |
| Huang, TS; Kuo, ML; Lin, JK | 1 |
| Forstner, GG; Forstner, JF; McCool, DJ | 1 |
| Hauri, HP; Naim, H; Sander, B | 1 |
| Crystal, RG; Kobayashi, N; Rosenthal, ER; Yoshimura, K | 1 |
| Alpers, DH; Becich, MJ; Engle, MJ; Grove, ML; Mahmood, A | 1 |
| Levine, AE; Ramesh, G | 1 |
| Augenlicht, L; Jarry, A; Laboisse, C; Palumbo, L; Racevskis, J; Velcich, A | 1 |
| Luzio, JP; Shurety, W | 1 |
| Cohen, MC; Zaifert, K | 1 |
| Ausiello, DA; Breuer, W; Cabantchik, IZ; Glickstein, H; Kartner, N; Riordan, JR | 1 |
| Augenlicht, LH; Velcich, A | 1 |
| Barthelson, RA; Gruenert, DC; Mrsny, RJ; Shen, BQ; Sigal, E; Skach, W; Widdicombe, JH | 1 |
| Dang, J; Doe, WF; Liang, X; Wang, Y | 1 |
| Cacace, AM; Goldstein, DR; Weinstein, IB | 1 |
| Chiang, HS; Huang, TF; Peng, HC | 1 |
| Chiang, H; Fu, YD; Li, NG; Shao, BJ; Wu, RY | 1 |
| Keogh, JP; Slomiany, A; Slomiany, BL; Vossough, S; Zirvi, KA | 1 |
| Dang, J; Doe, WF; Jones, CJ; Liang, X; Olsen, JE; Wang, Y | 1 |
| Bissonnette, M; Brasitus, TA; Frawley, BP; Hartmann, SC; Niedziela, SM; Perlman, RL; Roy, HK; Sitrin, MD; Tien, XY | 1 |
| Levine, AE | 1 |
| Brandsch, M; Ganapathy, V; Leibach, FH; Miyamoto, Y | 2 |
| Batlle, E; Fabre, M; García de Herreros, A | 1 |
| Abrahamson, M; Bachmann, D; Berdoz, J; Keppler, D; Sordat, B; Waridel, P | 1 |
| Balagué, C; Batlle, E; Fabre, M; García de Herreros, A; Real, FX | 1 |
| Easom, RA; Riehl, TE; Stenson, WF; Turk, J | 1 |
| Born, E; Chen, H; Dixon, B; Field, FJ; Mathur, S | 1 |
| Fabre, M; García de Herreros, A | 1 |
| Forstner, G; Forstner, J; McCool, D; Zhang, Y | 1 |
| Carbone, PP; Carey, P; Gilmore, D; Love, RR; Pomplun, M; Tutsch, KD; Verma, AK; Wilding, G | 1 |
| Colgan, SP; Delp, C; Gillece-Castro, B; Madara, JL; Mrsny, RJ; Parkos, CA; Patapoff, TW | 1 |
| Adham, NF; Ament, ME; Costea, NV; Heng, MC; Heng, MK; Song, MK | 1 |
| Akimoto, S; Hirohashi, S; Ino, Y; Kanai, Y; Ochiai, A; Sakamoto, M | 1 |
| Balogh, A; Csuka, O; Kéri, G; Teplán, I | 1 |
| Khaled, Z; Maltese, JY; Narayanan, R; Nichols, G; Perez, JR; Sartorelli, AC; Sharma, HW; Sokoloski, JA; Stein, CA; Telang, NT | 1 |
| Hakomori, S; Igarashi, Y; Masamune, A; Ohta, H; Sakakura, C; Shirahama, T; Sweeney, EA | 1 |
| Handa, H; Hiramoto, M; Hirano, F; Makino, I; Makino, Y; Okamoto, K; Tanada, H | 1 |
| Folini, M; Lin, HC; Mischak, H; Perletti, GP; Piccinini, F; Tashjian, AH | 1 |
| Eastman, A; McBain, JA; Mueller, GC; Pettit, GR; Simmons, DL | 1 |
| Gu, DS; Kagnoff, MF; Roebuck, KA | 1 |
| Cafferata, EG; Gonzalez-Guerrico, AM; Pivetta, OH; Santa-Coloma, TA | 1 |
| Chiantore, MV; De Luca, LM; Kósa, K; Rosenberg, MI | 1 |
| Bianco, AR; Caraglia, M; Correale, P; Giuliano, M; Guarrasi, R; Marinetti, MR; Procopio, A; Tagliaferri, P | 1 |
| Bruyneel, E; Cornelissen, M; Gohon, L; Mareel, M; van Hengel, J; Vermeulen, S; von Roy, F | 1 |
| Eastman, A; McBain, JA; Mueller, GC; Nobel, CS | 1 |
| Furuishi, K; Matsuoka, H; Misumi, S; Shoji, S; Takahashi, I; Takama, M | 1 |
| Aliprandis, ET; Kashfi, K; Merritt, G; Prada, F; Rigas, B | 1 |
| Gschwendt, M; Kittstein, W; Krammer, PH; Möller, P; Sträter, J; von Reyher, U | 1 |
| André, F; Dagorn, JC; Farnarier, C; Iovanna, JL; Lissitzky, JC; Mallo, GV; Marvaldi, J; Soubeyran, P | 1 |
| Du, M; Sansores-Garcia, L; Wu, KK; Zu, Z | 1 |
| Ding, EX; Fujiwara, T; Hizuta, A; Hongo, T; Ishii, T; Iwagaki, H; Morimoto, Y; Tanaka, N; Tanida, T; Yamano, T | 1 |
| Chadee, K; Yu, Y | 1 |
| Chiang, HS; Huang, TF; Lin, SW; Yang, RS | 1 |
| Groen, AK; Klinkspoor, JH; Lee, SP; Mok, KS; Tytgat, GN; Van Klinken, BJ | 1 |
| Nishioka, M; Okumura, K; Sasazuki, T; Shirasawa, S | 1 |
| Gibson, PR; Phillips, WA; Rickard, KL; Young, GP | 1 |
| Dickinson, CJ; Sawada, M; Stepan, VM; Todisco, A | 1 |
| Bond, JS; Matters, GL | 1 |
| Karnes, WE; Klein, IK; Penington, RC; Weller, SG | 1 |
| Farrow, S; Holloway, KA; Howells, L; Kaptein, A; Manson, MM; Munks, RJ; Plummer, SM | 1 |
| Cafferata, EG; Giordano, L; González-Guerrico, AM; Pivetta, OH; Santa-Coloma, TA | 1 |
| Fukuda, K; Matsushima-Hibiya, Y; Mutoh, H; Mutoh, M; Sugimura, T; Takahashi, M; Wakabayashi, K | 1 |
| Ahn, DH; Baek, SH; Chae, HS; Erickson, RH; Han, SY; Kim, HR; Kim, YS; Lee, MS; Sleisenger, MH | 1 |
| Baba, I; Fukuyama, K; Iwamoto, R; Mekada, E; Nishioka, M; Okumura, K; Sasazuki, T; Shirasawa, S; Tsunoda, T; Yamamoto, K | 1 |
| Coffey, RJ; Gellert, N; Lu, M; Mayne, GC; Nègre-Salvayre, A; Neuzil, J; Olejnicka, B; Ostermann, G; Schröder, A; Stícha, M; Weber, C; Weber, T | 1 |
| Khachik, F; Masuda, M; Murakoshi, M; Narisawa, T; Nishino, H; Okuda, M; Onozuka, M; Satomi, Y; Takasuka, N; Takayasu, J; Tokuda, H; Tsuruta, J; Yamaguchi, S; Yano, M | 1 |
| Beauchemin, N; Fournès, B; Létourneau, S; Sadekova, S; Turbide, C | 1 |
| Chadee, K; De Waele, C; Yu, Y | 1 |
| Polakis, P; Soloviev, I; Tice, DA | 1 |
| Jiwajinda, S; Kim, HW; Kinoshita, T; Koshimizu, K; Murakami, A; Nakamura, Y; Ohigashi, H; Takahashi, D; Terao, J; Yoshihiro, A | 1 |
| Ahn, DH; Basbaum, CB; Crawley, SC; Fan, NQ; Gum, JR; Han, SY; Kim, YS; Lee, BH; Lee, HW; Li, JD; Sleisenger, MH; Szymkowski, DE | 1 |
| Butruk, E; Ostrowski, J; Rochowska, M; Skurzak, H; Szczepiórkowski, Z; Trzeciak, L | 1 |
| Baguley, BC; Ching, LM; Gavin, JB; Thomsen, LL | 1 |
| Roomans, GM; von Euler, A | 1 |
| Chadee, K; Keller, K; Olivier, M | 1 |
| Lu, X; Seligy, VL | 1 |
| Bargon, J; Crystal, RG; Dalemans, W; Lecocq, JP; Pavirani, A; Trapnell, BC; Yoshimura, K | 1 |
| Chakrabarty, S | 1 |
| Berton, G; Cabrini, G; Dechecchi, MC; Gamberi, C; Rolfini, R; Tamanini, A | 1 |
| Castagna, M; Desjeux, JF; Fan, XT; Huang, XP | 1 |
| Bajnath, RB; de Jonge, HR; Groot, JA; van Hoeve, MH | 1 |
| Choi, PM; Weinstein, IB | 1 |
| Weinstein, IB | 1 |
| Leung, S; Miyamoto, NG | 1 |
| Franklin, CC; Kim, HD; Turner, JT; Wu, H | 1 |
| Dong, ZY; Fan, D; Gupta, KP; O'Brian, CA; Ward, NE | 1 |
| Verma, AK | 1 |
| Forstner, GG; Forstner, JF; Marcon, MA; McCool, DJ | 1 |
| Daviaud, D; Denis-Pouxviel, C; Gauthier, T; Murat, JC | 1 |
| Kopp, R; Mayer, P; Pfeiffer, A | 1 |
| Fuchimoto, S; Matsubara, N; Orita, K | 1 |
| Hansson, V; Jahnsen, T; Kvale, D; Taskén, K | 1 |
| McBain, JA; Mueller, GC; Pettit, GR | 2 |
| Bollinger, DW; Franklin, CC; Kim, HD; Turner, JT | 1 |
| Choi, PM; Tchou-Wong, KM; Weinstein, IB | 1 |
| Cherqui, G; Lévy, P; Picard, J; Robert, A; Wicek, D | 1 |
| Baron, PL; Carchman, RA; Collins, JM; Koretz, MJ; Parker, GA; Tokarz, AS | 1 |
| Allalouf, D; Friedman, J; Levinsky, H; Seger, M | 1 |
| Gjøen, T; Kolset, SO; Seljelid, R | 1 |
| Bozou, JC; Kitabgi, P; Magnaldo, I; Rochet, N; Vincent, JP | 1 |
| Friedman, E; Marian, B; Winawer, S | 1 |
| Bylund, DB; Jones, SB | 1 |
| Friedman, E; Isaksson, P; Marian, B; Newmark, H; Rafter, J; Winawer, S | 1 |
| Amar, S; Kitabgi, P; Vincent, JP | 1 |
| Bozou, JC; Couvineau, A; Kitabgi, P; Laburthe, M; Rouyer-Fessard, C; Vincent, JP | 1 |
| Bettetini, D; Culouscou, JM; Garrouste, F; Marvaldi, J; Pommier, G; Remacle-Bonnet, M | 1 |
| Haffen, K; Kedinger, M; Rochette-Egly, C | 1 |
| Kestenbach, U; Köpf-Maier, P | 1 |
| O'Brian, CA; Ward, NE | 1 |
| Kodama, M | 1 |
| Fitzer, CJ; Forde, KA; Guillem, JG; LoGerfo, P; O'Brian, CA; Treat, M; Weinstein, IB | 1 |
| Hoshijima, M; Kaibuchi, K; Ohyanagi, H; Saitoh, Y; Takai, Y; Takeyama, Y; Tanimoto, T | 1 |
5 review(s) available for tetradecanoylphorbol acetate and Cancer of Colon
| Article | Year |
|---|---|
Genetic predisposition to cancer in man: in vitro studies.
Topics: Adenoma; Antigens, Neoplasm; Carcinogens; Cell Division; Cell Membrane; Cell Transformation, Neoplastic; Cells, Cultured; Cholesterol; Colonic Neoplasms; Cytoskeleton; Disease Susceptibility; Fibroblasts; Fibronectins; Genes, Dominant; Humans; Mitochondria; Mutation; Neoplasms; Rectal Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Nonmutagenic mechanisms in carcinogenesis: role of protein kinase C in signal transduction and growth control.
Topics: Animals; Bacteria; Cell Line, Transformed; Cell Transformation, Neoplastic; Cocarcinogenesis; Colon; Colonic Neoplasms; Diglycerides; Enzyme Activation; Enzyme Induction; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Isoenzymes; Mice; Protein Kinase C; Proto-Oncogenes; Signal Transduction; Tetradecanoylphorbol Acetate | 1991 |
Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase.
Topics: Animals; Carcinogens; Colonic Neoplasms; Eflornithine; Female; Mammary Neoplasms, Experimental; Mice; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
[Biophysics of the neoplastic process].
Topics: Animals; Carcinogens; Carcinogens, Environmental; Cell Transformation, Neoplastic; Colonic Neoplasms; DNA; Free Radicals; Humans; Neoplasms, Experimental; Peptide Chain Termination, Translational; Smoking; Tetradecanoylphorbol Acetate | 1986 |
A multistage model for human colon carcinoma development integrating cell culture studies with pathology.
Topics: Adenoma; Animals; Cell Division; Cell Line; Cells, Cultured; Colonic Neoplasms; Culture Techniques; Deoxycholic Acid; Epidermal Growth Factor; Humans; Models, Biological; Plasminogen Activators; Precancerous Conditions; Tetradecanoylphorbol Acetate | 1985 |
1 trial(s) available for tetradecanoylphorbol acetate and Cancer of Colon
| Article | Year |
|---|---|
Randomized phase I chemoprevention dose-seeking study of alpha-difluoromethylornithine.
Topics: Adult; Carcinoma; Colonic Neoplasms; Eflornithine; Enzyme Induction; Female; Humans; Male; Ornithine Decarboxylase; Prostatic Neoplasms; Skin; Tetradecanoylphorbol Acetate; Urinary Bladder Neoplasms | 1993 |
159 other study(ies) available for tetradecanoylphorbol acetate and Cancer of Colon
| Article | Year |
|---|---|
Diclofenac down-regulates COX-2 induced expression of CD44 and ICAM-1 in human HT29 colorectal cancer cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Cell Survival; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Diclofenac; Down-Regulation; Gene Expression Regulation, Neoplastic; HCT116 Cells; HT29 Cells; Humans; Hyaluronan Receptors; Intercellular Adhesion Molecule-1; Tetradecanoylphorbol Acetate | 2021 |
[Sphingosine kinase 1 enhances the proliferation and invasion of human colon cancer LoVo cells through up-regulating FAK pathway and the expression of ICAM-1 and VCAM-1].
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Inhibitors; Focal Adhesion Kinase 1; Humans; Intercellular Adhesion Molecule-1; Neoplasm Invasiveness; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); RNA, Messenger; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Vascular Cell Adhesion Molecule-1 | 2013 |
Combined incubation of colon carcinoma cells with phorbol ester and mitochondrial uncoupling agents results in synergic elevated reactive oxygen species levels and increased γ-glutamyltransferase expression.
Topics: Acetophenones; Benzopyrans; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Line, Tumor; Colonic Neoplasms; Drug Combinations; Drug Synergism; Enzyme Inhibitors; gamma-Glutamyltransferase; HT29 Cells; Humans; Mitochondria; NADPH Oxidases; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; RNA Interference; RNA, Messenger; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Uncoupling Agents | 2014 |
[6]-Gingerol induces caspase-dependent apoptosis and prevents PMA-induced proliferation in colon cancer cells by inhibiting MAPK/AP-1 signaling.
Topics: Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinogens; Caspases; Catechols; Cell Line, Tumor; Colon; Colonic Neoplasms; Extracellular Signal-Regulated MAP Kinases; Fatty Alcohols; Humans; JNK Mitogen-Activated Protein Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Zingiber officinale | 2014 |
Response gene to complement 32 (RGC-32) expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4.
Topics: Adenocarcinoma; Ascitic Fluid; Cell Cycle Proteins; Cell Differentiation; Cell Line; Cell Movement; Cell Proliferation; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Interleukin-4; Interleukin-6; Leukocytes, Mononuclear; Lipopolysaccharides; Macrophage Activation; Macrophage Colony-Stimulating Factor; Macrophages; Muscle Proteins; Nerve Tissue Proteins; Primary Cell Culture; Signal Transduction; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 2015 |
Inhibitory effects of proton beam irradiation on integrin expression and signaling pathway in human colon carcinoma HT29 cells.
Topics: AMP-Activated Protein Kinases; Cell Adhesion; Cell Movement; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Integrins; Proton Therapy; Signal Transduction; Tetradecanoylphorbol Acetate | 2015 |
Cyclooxygenase-2 expression is related to the epithelial-to-mesenchymal transition in human colon cancers.
Topics: Adult; Aged; Aged, 80 and over; Blotting, Western; Cadherins; Cell Differentiation; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Cyclooxygenase 2; Dinoprostone; Epithelial Cells; Epithelium; Female; Homeodomain Proteins; HT29 Cells; Humans; Immunohistochemistry; In Vitro Techniques; Male; Mesoderm; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; Snail Family Transcription Factors; Tetradecanoylphorbol Acetate; Transcription Factors; Zinc Finger E-box-Binding Homeobox 1 | 2009 |
Homeobox gene Dlx-2 is implicated in metabolic stress-induced necrosis.
Topics: Antigens, Surface; Apoptosis; Breast Neoplasms; Cell Aggregation; Cell Line, Tumor; Colonic Neoplasms; Female; Gene Expression Profiling; Gene Knockdown Techniques; Glucose; Humans; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membranes; Necrosis; Neoplasms; Oligonucleotide Array Sequence Analysis; Ovarian Neoplasms; Permeability; Reactive Oxygen Species; RNA Interference; Stress, Physiological; Tetradecanoylphorbol Acetate | 2011 |
Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Adenoma; Animals; Animals, Inbred Strains; Azoxymethane; Cell Transformation, Neoplastic; Chemokines, CXC; Colitis; Colonic Neoplasms; Dermatitis, Contact; Dextran Sulfate; Gene Expression; Mice; Mice, 129 Strain; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Papilloma; Peroxidase; Precancerous Conditions; Receptors, Interleukin-8B; Skin Neoplasms; Statistics, Nonparametric; Tetradecanoylphorbol Acetate; Tumor Burden | 2012 |
Quantitative analysis of ERK signaling inhibition in colon cancer cell lines using phospho-specific flow cytometry.
Topics: Blotting, Western; Butadienes; Carcinogens; Colonic Neoplasms; Enzyme Inhibitors; Flow Cytometry; Fluorescent Antibody Technique; HCT116 Cells; HT29 Cells; Humans; MAP Kinase Signaling System; Nitriles; Phosphorylation; Predictive Value of Tests; Reproducibility of Results; Tetradecanoylphorbol Acetate | 2012 |
Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells.
Topics: Adenocarcinoma; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Chromosome Mapping; Colonic Neoplasms; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Disease Progression; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Transport; Pyridines; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 2002 |
Suppression of serum-induced c-jun expression by activated Ki-ras in human colon cancer cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colonic Neoplasms; Culture Media, Serum-Free; Cytosol; Depression, Chemical; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Immediate-Early; Genes, ras; Humans; Protein Kinase C; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer.
Topics: Active Transport, Cell Nucleus; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; DNA, Neoplasm; Enzyme Activation; Humans; I-kappa B Kinase; I-kappa B Proteins; Isoenzymes; Membrane Proteins; Neoplasm Proteins; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein Binding; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyrazoles; Stomach Neoplasms; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription Factor RelA; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha | 2003 |
TR3/Nur77 in colon cancer cell apoptosis.
Topics: Apoptosis; bcl-2-Associated X Protein; Butyrates; Cell Nucleus; Colonic Neoplasms; Cytochrome c Group; DNA, Neoplasm; Green Fluorescent Proteins; Humans; Luminescent Proteins; Mitochondria; Nuclear Receptor Subfamily 4, Group A, Member 1; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Receptors, Steroid; Receptors, Thyroid Hormone; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 2003 |
Regulation of butyrate uptake in Caco-2 cells by phorbol 12-myristate 13-acetate.
Topics: Adenocarcinoma; Butyric Acid; Caco-2 Cells; Carcinogens; Colonic Neoplasms; Drug Administration Schedule; Humans; Hydrocortisone; Lactic Acid; Monocarboxylic Acid Transporters; Symporters; Tetradecanoylphorbol Acetate | 2004 |
Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B.
Topics: Colonic Neoplasms; Enzyme Inhibitors; Gene Expression Regulation; Humans; NF-kappa B; Promoter Regions, Genetic; Protein Biosynthesis; Protein Kinase C; Protein Kinase C-delta; Proteins; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate | 2003 |
Functional imaging of proteolysis: stromal and inflammatory cells increase tumor proteolysis.
Topics: Breast Neoplasms; Carcinoma; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Survival; Coculture Techniques; Collagen; Collagen Type IV; Colonic Neoplasms; Drug Combinations; Endopeptidases; Humans; Hydroxamic Acids; Image Processing, Computer-Assisted; Immunohistochemistry; Laminin; Macrophages; Monocytes; Neoplasms; Proteoglycans; Spheroids, Cellular; Stromal Cells; Tetradecanoylphorbol Acetate; U937 Cells | 2003 |
Enzymatic synthesis of tea theaflavin derivatives and their anti-inflammatory and cytotoxic activities.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Biflavonoids; Biochemistry; Carcinoma, Squamous Cell; Catechin; Cell Division; Cells, Cultured; Colonic Neoplasms; Drug Evaluation, Preclinical; Ear Diseases; Edema; Esophageal Neoplasms; Female; Horseradish Peroxidase; Humans; Macrophages; Mice; Mice, Inbred Strains; Structure-Activity Relationship; Tea; Tetradecanoylphorbol Acetate; Toxicity Tests; Tumor Cells, Cultured | 2004 |
Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB-dependent pathway.
Topics: Cell Line, Tumor; Colonic Neoplasms; Dactinomycin; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Mitogen-Activated Protein Kinases; NF-kappa B; Promoter Regions, Genetic; Protein Kinase C; Proteins; Proto-Oncogene Proteins c-raf; Tetradecanoylphorbol Acetate; TNF Receptor-Associated Factor 1; Transcription, Genetic | 2004 |
[Pharmacological effects of Daphne genkwa and Chinese medical prescription, "Jyu-So-To"].
Topics: Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Azoxymethane; Colonic Neoplasms; Daphne; Dinitrofluorobenzene; Drugs, Chinese Herbal; Ear Diseases; Edema; Female; Hypersensitivity; Male; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Phytotherapy; Plant Extracts; Tetradecanoylphorbol Acetate | 2004 |
Antiproliferative crude soy saponin extract modulates the expression of IkappaBalpha, protein kinase C, and cyclooxygenase-2 in human colon cancer cells.
Topics: Blotting, Western; Cell Division; Colonic Neoplasms; Cyclooxygenase 2; Gene Expression Regulation; Glycine max; Humans; I-kappa B Proteins; Isoenzymes; Membrane Proteins; NF-KappaB Inhibitor alpha; Plant Extracts; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Saponins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2004 |
Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receptor-g
Topics: Cell Survival; Colonic Neoplasms; Consensus Sequence; Cyclooxygenase 2; Electrophoretic Mobility Shift Assay; Enzyme Activation; Enzyme Inhibitors; Genes, Dominant; Genes, jun; Humans; Immunologic Factors; Isoenzymes; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Protein Binding; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A | 2004 |
Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205.
Topics: Acetamides; Acetophenones; Alkaloids; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Benzophenanthridines; Benzopyrans; Calpain; Caspase 3; Caspase Inhibitors; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cysteine Proteinase Inhibitors; Dipeptides; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Histones; Humans; Indomethacin; Kinetics; Phenanthridines; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Pyrans; Spiro Compounds; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2005 |
Expression and function of the nuclear factor of activated T cells in colon carcinoma cells: involvement in the regulation of cyclooxygenase-2.
Topics: Amino Acid Sequence; Calcimycin; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygenase 2; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Humans; Membrane Proteins; Molecular Sequence Data; NFATC Transcription Factors; Nuclear Proteins; Peptide Fragments; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sequence Deletion; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription Factors | 2005 |
Na+/H+ exchanger activity is increased in doxorubicin-resistant human colon cancer cells and its modulation modifies the sensitivity of the cells to doxorubicin.
Topics: Amiloride; Colonic Neoplasms; Doxorubicin; Drug Resistance, Neoplasm; HT29 Cells; Humans; Hydrogen-Ion Concentration; Monensin; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate | 2005 |
Colon cancer cell-derived high mobility group 1/amphoterin induces growth inhibition and apoptosis in macrophages.
Topics: Animals; Apoptosis; Cell Line; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Colonic Neoplasms; Culture Media, Conditioned; Glycation End Products, Advanced; HMGB1 Protein; Humans; Immunoblotting; Macrophages; MAP Kinase Signaling System; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oligonucleotides; Oligonucleotides, Antisense; Rats; Rats, Inbred F344; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; U937 Cells | 2005 |
Matrix metalloproteinases 9 and 10 inhibit protein kinase C-potentiated, p53-mediated apoptosis.
Topics: Adenocarcinoma; Apoptosis; Caspases; Cell Line, Tumor; Colonic Neoplasms; Down-Regulation; Humans; Intracellular Membranes; Matrix Metalloproteinase 10; Matrix Metalloproteinase 9; Membrane Potentials; Metalloendopeptidases; Mitochondria; Phosphatidylserines; Protein Kinase C; RNA, Small Interfering; Tetracycline; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2005 |
Distinct differences between TNF receptor 1- and TNF receptor 2-mediated activation of NFkappaB.
Topics: beta-Galactosidase; Cell Line, Tumor; Colonic Neoplasms; Cytomegalovirus; Enhancer Elements, Genetic; Genes, Reporter; Humans; NF-kappa B; Promoter Regions, Genetic; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Sodium Salicylate; Tetradecanoylphorbol Acetate | 2005 |
Role of cytokines in promoting immune escape of FasL-expressing human colon cancer cells.
Topics: Cell Communication; Cell Line, Tumor; Coculture Techniques; Colonic Neoplasms; Cytokines; Cytotoxicity, Immunologic; Fas Ligand Protein; fas Receptor; Glioma; Humans; Immunohistochemistry; Ionomycin; Ionophores; Jurkat Cells; Membrane Glycoproteins; Phytohemagglutinins; T-Lymphocytes; T-Lymphocytes, Regulatory; Tetradecanoylphorbol Acetate | 2005 |
Ursodeoxycholic acid inhibits translocation of protein kinase C in human colonic cancer cell lines.
Topics: Anticarcinogenic Agents; Blotting, Western; Cell Line, Tumor; Cell Shape; Colonic Neoplasms; Deoxycholic Acid; Green Fluorescent Proteins; Humans; Protein Kinase C; Tetradecanoylphorbol Acetate; Transfection; Ursodeoxycholic Acid | 2005 |
Chemopreventive effect of protein extract of Asterina pectinifera in HT-29 human colon adenocarcinoma cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Asterina; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Glutathione Transferase; HT29 Cells; Humans; NAD(P)H Dehydrogenase (Quinone); Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Proteins; Tetradecanoylphorbol Acetate | 2006 |
Requirement of the enzymatic and signaling activities of plasmin for phorbol-ester-induced scattering of colon cancer cells.
Topics: Aminocaproic Acid; Cell Movement; Colonic Neoplasms; Culture Media, Serum-Free; Enzyme Inhibitors; Extracellular Matrix; Extracellular Signal-Regulated MAP Kinases; Fibrinolysin; Flavonoids; Hepatocyte Growth Factor; HT29 Cells; Humans; Integrin beta1; Pertussis Toxin; Phosphorylation; Plasminogen; Plasminogen Activator Inhibitor 1; Protein Kinase C-alpha; Pyrazoles; Pyrimidines; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Signal Transduction; Tetradecanoylphorbol Acetate; Urokinase-Type Plasminogen Activator | 2006 |
Selenium regulates cyclooxygenase-2 and extracellular signal-regulated kinase signaling pathways by activating AMP-activated protein kinase in colon cancer cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Cell Growth Processes; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Drug Interactions; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; HeLa Cells; HT29 Cells; Humans; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Nude; Multienzyme Complexes; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Ribonucleotides; Selenic Acid; Selenium Compounds; Tetradecanoylphorbol Acetate | 2006 |
Lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of Krüppel-like factor 5.
Topics: beta Catenin; Caco-2 Cells; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carcinogens; Cell Proliferation; Colonic Neoplasms; Elongation Factor 2 Kinase; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Intestinal Mucosa; Kruppel-Like Transcription Factors; Lysophospholipids; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Protein Kinase C; Protein Kinase C beta; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Wnt Proteins | 2007 |
Inhibition of cell growth and induction of apoptosis via inactivation of NF-kappaB by a sulfurcompound isolated from garlic in human colon cancer cells.
Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; DNA, Neoplasm; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Garlic; Gene Expression Regulation; Humans; NF-kappa B; Tetradecanoylphorbol Acetate; Thiophenes; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2007 |
Growth inhibitory effects of obovatol through induction of apoptotic cell death in prostate and colon cancer by blocking of NF-kappaB.
Topics: Apoptosis; Biphenyl Compounds; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Humans; Male; NF-kappa B; Phenyl Ethers; Phosphorylation; Prostatic Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2008 |
Increased sensitivity of fibroblasts of skin from patients with adenomatosis coli and Peutz-Jegher's syndrome to transformation by murine sarcoma virus.
Topics: Adenoma; Adolescent; Adult; Cell Transformation, Viral; Child; Colonic Neoplasms; Female; Fibroblasts; Humans; Intestinal Polyps; Leukemia Virus, Murine; Male; Middle Aged; Peutz-Jeghers Syndrome; Sarcoma Viruses, Murine; Skin; Tetradecanoylphorbol Acetate | 1980 |
A model for human colon carcinoma evolution based on the differential response of cultured preneoplastic, premalignant, and malignant cells to 12-O-tetradecanoylphorbol-13-acetate.
Topics: Adenoma; Adult; Aged; Alkaloids; Carcinogens; Cells, Cultured; Colon; Colonic Neoplasms; Female; Humans; Intestinal Polyps; Lyngbya Toxins; Male; Middle Aged; Models, Biological; Phorbols; Precancerous Conditions; Tetradecanoylphorbol Acetate | 1984 |
The effect of promoters on 1,2-dimethylhydrazine-induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; DNA; Female; Hyperplasia; Intestinal Mucosa; Male; Metaphase; Methylhydrazines; Mice; Mice, Inbred C57BL; Phorbols; Tetradecanoylphorbol Acetate; Time Factors; Vincristine | 1984 |
12-O-tetradecanoylphorbol-13-acetate-induced effects in fibroblasts from humans predisposed to colon cancer.
Topics: Cells, Cultured; Colonic Neoplasms; Fibroblasts; Humans; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
In vitro studies of the possible mechanisms whereby tumour promoters mediate their responses.
Topics: Carcinogens; Cell Movement; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Aberrations; Colonic Neoplasms; Eye Neoplasms; Fibroblasts; Humans; Methylnitronitrosoguanidine; Mutation; Retinoblastoma; Skin; Tetradecanoylphorbol Acetate | 1983 |
Positive two-stage carcinogenesis in female Sprague-Dawley rats using 7,12-dimethylbenz(a)anthracene (dmba) as initiator and 12-o-tetradecanoylphorbol-13-acetate (tps) as promotor. Results of a pilot study.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benz(a)Anthracenes; Castration; Cocarcinogenesis; Colonic Neoplasms; Female; Intestinal Neoplasms; Liver Neoplasms; Phorbols; Rats; Skin Neoplasms; Stomach; Stomach Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Prevention of hereditary large bowel cancer: tissue culture assays and logistics.
Topics: Actins; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Colonic Neoplasms; Humans; Oncogenic Viruses; Rectal Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Differential response of premalignant epithelial cell classes to phorbol ester tumor promoters and to deoxycholic acid.
Topics: Cell Division; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Colonic Neoplasms; Deoxycholic Acid; DNA Replication; Epithelium; Humans; Peptide Hydrolases; Phorbols; Plasminogen Activators; Precancerous Conditions; Protease Inhibitors; Tetradecanoylphorbol Acetate | 1981 |
Disrupted communication between late-stage premalignant human colon epithelial cells by 12-O tetradecanoylphorbol-13-acetate.
Topics: Adenoma; Cell Communication; Cells, Cultured; Colonic Neoplasms; Epithelium; Humans; Phorbols; Precancerous Conditions; Tetradecanoylphorbol Acetate | 1982 |
Are all normal diploid human cell strains alike? Relevance to carcinogenic mechanisms in vitro.
Topics: Adenocarcinoma; Cell Division; Cells, Cultured; Colonic Neoplasms; Diploidy; Embryo, Mammalian; Female; Fibroblasts; Humans; Kinetics; Male; Phorbols; Pregnancy; Skin; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate | 1982 |
Tumor promoter induces loss of anchorage dependence in human skin fibroblasts from individuals genetically predisposed to cancer.
Topics: Adenoma; Agar; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Colonic Neoplasms; Fibroblasts; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Phorbols; Rectal Neoplasms; Skin; Tetradecanoylphorbol Acetate | 1980 |
The use of a tumor promoter as a single parameter approach for the detection of individuals genetically predisposed to colorectal cancer.
Topics: Cell Division; Cells, Cultured; Colonic Neoplasms; Female; Fibroblasts; Humans; Male; Phorbols; Rectal Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Preferential requirement for protein tyrosine phosphatase activity in the 12-O-tetradecanoylphorbol-13-acetate-induced differentiation of human colon cancer cells.
Topics: Cell Differentiation; Chlorides; Colonic Neoplasms; Enzyme Activation; Ethers, Cyclic; Genistein; Humans; Isoflavones; Okadaic Acid; Protein Tyrosine Phosphatases; Proteoglycans; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Zinc Compounds | 1995 |
Regulated and unregulated pathways for MUC2 mucin secretion in human colonic LS180 adenocarcinoma cells are distinct.
Topics: Adenocarcinoma; Biomarkers, Tumor; Calcimycin; Carbachol; Cell Size; Colchicine; Colonic Neoplasms; Cytochalasin D; Cytoplasmic Granules; Golgi Apparatus; Humans; Microscopy, Electron; Monensin; Mucin-2; Mucins; Neoplasm Proteins; Nocodazole; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Induction of lactase biosynthesis in the human intestinal epithelial cell line Caco-2.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenocarcinoma; beta-Galactosidase; Bucladesine; Cell Line; Colforsin; Colonic Neoplasms; Cyclic AMP; Dactinomycin; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Epithelium; Humans; Lactase; Lactase-Phlorizin Hydrolase; Methionine; Microvilli; Sucrase-Isomaltase Complex; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Transfer of a constitutive viral promoter-cystic fibrosis transmembrane conductance regulator cDNA to human epithelial cells conveys resistance to down-regulation of cAMP-regulated Cl- secretion in the presence of inflammatory stimuli.
Topics: Blotting, Northern; Blotting, Southern; Chlorides; Colforsin; Colonic Neoplasms; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; DNA, Complementary; Epithelium; Gene Expression Regulation; Gene Transfer Techniques; Genetic Vectors; Membrane Proteins; Moloney murine leukemia virus; Promoter Regions, Genetic; Repetitive Sequences, Nucleic Acid; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Appearance of surfactant-like particles in apical medium of Caco-2 cells may occur via tight junctions.
Topics: Adenocarcinoma; Alkaline Phosphatase; Animals; Antibodies; Cell Line; Cell Membrane; Cell Membrane Permeability; Colonic Neoplasms; Cytochalasin D; Humans; Hypertonic Solutions; Intercellular Junctions; Intestine, Small; Microscopy, Electron; Organelles; Rabbits; Raffinose; Sucrose; Surface-Active Agents; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1995 |
Pro-transforming growth factor-alpha processing in human colon carcinoma cells: role of protein kinase C.
Topics: Colonic Neoplasms; Humans; Isoenzymes; Naphthalenes; Phorbol Esters; Protein Kinase C; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1995 |
Patterns of expression of lineage-specific markers during the in vitro-induced differentiation of HT29 colon carcinoma cells.
Topics: Alkaline Phosphatase; Antigens, Differentiation; Antigens, Neoplasm; Biomarkers; Butyrates; Butyric Acid; Carcinoembryonic Antigen; Carcinoma; Cell Differentiation; Colforsin; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Intestinal Mucosa; Mucin-2; Mucin-3; Mucins; Neoplasm Proteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Differential modulation of apical and basolateral endocytosis in Caco-2 cells.
Topics: Adenocarcinoma; Animals; Biological Transport; Cell Line; Cell Membrane; Colonic Neoplasms; Dogs; Endocytosis; Humans; Intracellular Signaling Peptides and Proteins; Kidney; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Protein Kinase C; Proteins; Ricin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
COLO 205 utilizes E-selectin to adhere to human endothelium.
Topics: Antibodies, Monoclonal; Cell Adhesion; Cell Adhesion Molecules; Colonic Neoplasms; E-Selectin; Endothelium, Vascular; Flow Cytometry; Humans; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Umbilical Veins; Up-Regulation | 1993 |
Protein kinase C mediates down-regulation of cystic fibrosis transmembrane conductance regulator levels in epithelial cells.
Topics: Adenocarcinoma; Colonic Neoplasms; Cycloheximide; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dactinomycin; Epithelium; Gene Expression Regulation, Neoplastic; Humans; Indoles; Maleimides; Membrane Proteins; Pancreatic Neoplasms; Protein Biosynthesis; Protein Kinase C; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1993 |
Regulated expression of an intestinal mucin gene in HT29 colonic carcinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenocarcinoma; Bucladesine; Calcimycin; Colforsin; Colonic Neoplasms; DNA Probes; Ethers, Cyclic; Gene Expression Regulation, Neoplastic; Humans; Intestinal Mucosa; Ionomycin; Ionophores; Kinetics; Mucins; Okadaic Acid; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Mechanism of inhibition of cAMP-dependent epithelial chloride secretion by phorbol esters.
Topics: Blotting, Western; Cell Membrane Permeability; Chlorides; Colonic Neoplasms; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Electric Conductivity; Epithelium; Glycosylation; Humans; Immunosorbent Techniques; Membrane Proteins; Potassium Channels; Protein Kinase C; RNA, Messenger; Rubidium Radioisotopes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Amiloride modulates urokinase gene expression at both transcription and post-transcription levels in human colon cancer cells.
Topics: Amiloride; Colonic Neoplasms; Cycloheximide; Gene Expression; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic; Tumor Cells, Cultured; Up-Regulation; Urokinase-Type Plasminogen Activator | 1995 |
Overexpression of protein kinase C beta 1 in the SW480 colon cancer cell line causes growth suppression.
Topics: Animals; Blotting, Western; Cell Division; Clone Cells; Colonic Neoplasms; Humans; Isoenzymes; Mice; Mice, Nude; Protein Kinase C; Rats; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured | 1995 |
Characterization of integrin expression and regulation on SW-480 human colon adenocarcinoma cells and the effect of rhodostomin on basal and upregulated tumor cell adhesion.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adenocarcinoma; Antibodies, Monoclonal; Binding Sites, Antibody; Cell Adhesion; Colonic Neoplasms; Extracellular Matrix; Fibronectins; Fluorescent Antibody Technique; Humans; Hydroxyeicosatetraenoic Acids; Integrins; Peptides; Platelet Aggregation Inhibitors; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 1994 |
Effects of 2.45-GHz microwave radiation and phorbol ester 12-O-tetradecanoylphorbol-13-acetate on dimethylhydrazine-induced colon cancer in mice.
Topics: Adenomatous Polyps; Animals; Carcinoma; Cocarcinogenesis; Colonic Neoplasms; Colonic Polyps; Dimethylhydrazines; Female; Male; Mice; Mice, Inbred BALB C; Microwaves; Neoplasms, Radiation-Induced; Radiation Dosage; Tetradecanoylphorbol Acetate | 1994 |
Pharmacological alterations of cellular transglutaminase activity and invasiveness in human colorectal carcinoma cells.
Topics: Adenocarcinoma; Colonic Neoplasms; Colorectal Neoplasms; Humans; Neoplasm Invasiveness; Retinoids; Tetradecanoylphorbol Acetate; Transglutaminases; Tretinoin; Tumor Cells, Cultured | 1993 |
Human urokinase receptor expression is inhibited by amiloride and induced by tumor necrosis factor and phorbol ester in colon cancer cells.
Topics: Amiloride; Cell Nucleus; Colonic Neoplasms; Cycloheximide; Gene Expression; Humans; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1994 |
1,25(OH)2 vitamin D3 activates PKC-alpha in Caco-2 cells: a mechanism to limit secosteroid-induced rise in [Ca2+]i.
Topics: Calcitriol; Calcium; Colonic Neoplasms; Enzyme Activation; Humans; Inositol 1,4,5-Trisphosphate; Intracellular Membranes; Isoenzymes; Osmolar Concentration; Protein Kinase C; Tetradecanoylphorbol Acetate; Time Factors; Tissue Distribution; Tumor Cells, Cultured | 1994 |
Involvement of protein kinase C and an elastase-like enzyme in the processing of transforming growth factor-alpha in human colon carcinoma cell lines.
Topics: Colonic Neoplasms; Detergents; Enzyme Activation; Humans; Pancreatic Elastase; Protease Inhibitors; Protein Kinase C; Sensitivity and Specificity; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1994 |
Expression and protein kinase C-dependent regulation of peptide/H+ co-transport system in the Caco-2 human colon carcinoma cell line.
Topics: Alkaloids; Biological Transport; Carrier Proteins; Cell Division; Colonic Neoplasms; Dipeptides; Diterpenes; Humans; Hydrogen; Kinetics; Protein Kinase C; Sodium; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Antipeptide antibodies directed against the C-terminus of protein kinase C zeta (PKC zeta) react with a Ca(2+)- and TPA-sensitive PKC in HT-29 human intestinal epithelial cells.
Topics: Amino Acid Sequence; Antibodies; Antibody Specificity; Calcium; Colonic Neoplasms; Egtazic Acid; Epithelium; Humans; Isoenzymes; Molecular Sequence Data; Peptide Fragments; Phosphatidylserines; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Latency of cathepsin B secreted by human colon carcinoma cells is not linked to secretion of cystatin C and is relieved by neutrophil elastase.
Topics: Adenocarcinoma; Ammonium Chloride; Cathepsin B; Colonic Neoplasms; Cystatin C; Cystatins; Enzyme Activation; Humans; Leukocyte Elastase; Neutrophils; Pancreatic Elastase; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
The tumor promoter 12-O-tetradecanoylphorbol-13-acetate blocks differentiation of HT-29 human colon cancer cells.
Topics: Biomarkers; Cell Differentiation; Colon; Colonic Neoplasms; Humans; Isoenzymes; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Regulation of paracellular permeability in Caco-2 cell monolayers by protein kinase C.
Topics: Adenocarcinoma; Alkaloids; Carbachol; Cell Line; Cell Membrane; Cell Membrane Permeability; Colonic Neoplasms; Enzyme Activation; Glycerides; Humans; Kinetics; Mannitol; Membrane Potentials; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1993 |
Release of ceramide after membrane sphingomyelin hydrolysis decreases the basolateral secretion of triacylglycerol and apolipoprotein B in cultured human intestinal cells.
Topics: Apolipoproteins B; Cell Membrane; Cell Survival; Ceramides; Cholesterol Esters; Colonic Neoplasms; Humans; Hydrolysis; Intestinal Mucosa; Kinetics; Lipids; Methionine; Phospholipids; Protein Kinase C; RNA, Messenger; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sulfur Radioisotopes; Tetradecanoylphorbol Acetate; Triglycerides; Tumor Cells, Cultured; Type C Phospholipases | 1993 |
Phorbol ester-induced scattering of HT-29 human intestinal cancer cells is associated with down-modulation of E-cadherin.
Topics: Cadherins; Calcium; Cell Adhesion; Cell Aggregation; Cell Division; Colonic Neoplasms; Down-Regulation; Humans; Intercellular Junctions; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Mucin secretion by T84 cells: stimulation by PKC, Ca2+, and a protein kinase activated by Ca2+ ionophore.
Topics: Adenocarcinoma; Alkaloids; Calcimycin; Calcium; Colonic Neoplasms; Culture Media; Down-Regulation; Egtazic Acid; Humans; Mucins; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
5'-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers.
Topics: Adenine Nucleotides; Adenosine Monophosphate; Chlorides; Chromatography, High Pressure Liquid; Colonic Neoplasms; Culture Media, Conditioned; Epithelium; Humans; Intestines; Kinetics; Leukemia, Promyelocytic, Acute; Models, Biological; Neutrophils; Ribonucleotides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Regulation of taurine transport in human colon carcinoma cell lines (HT-29 and Caco-2) by protein kinase C.
Topics: Biological Transport; Colchicine; Colonic Neoplasms; Cycloheximide; Cytochalasin D; Dactinomycin; Humans; Kinetics; Protein Kinase C; Taurine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1993 |
Metabolic alterations of zinc and prostaglandins in both human and animal colonic tumor cells.
Topics: Animals; Azoxymethane; Base Sequence; Carcinogens; Colonic Neoplasms; Dinoprost; Dinoprostone; DNA, Neoplasm; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Humans; Molecular Sequence Data; Prostaglandin-Endoperoxide Synthases; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Zinc | 1995 |
Formation of focal adhesion and spreading of polarized human colon cancer cells in association with tyrosine phosphorylation of paxillin in response to phorbol ester.
Topics: Antibodies, Monoclonal; Binding, Competitive; Cell Adhesion; Cell Adhesion Molecules; Cell Division; Cell Polarity; Colonic Neoplasms; Cytoskeletal Proteins; Humans; Integrins; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Phosphatidylcholine could be the source of 1,2-DAG which activates protein kinase C in EGF-stimulated colon carcinoma cells (HT29).
Topics: Colonic Neoplasms; Diglycerides; Drug Interactions; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; HT29 Cells; Humans; Phosphates; Phosphatidylcholines; Phosphatidylinositols; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate | 1995 |
Differentiation of immortal cells inhibits telomerase activity.
Topics: Animals; Base Sequence; Butyrates; Butyric Acid; Calcitriol; Cell Differentiation; Cell Line; Cell Nucleus; Colonic Neoplasms; Cytoplasm; Dimethyl Sulfoxide; Growth Inhibitors; HL-60 Cells; Humans; Interleukin-6; Kidney; Leukemia Inhibitory Factor; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphokines; Mice; Repetitive Sequences, Nucleic Acid; Stem Cells; Telomerase; Teratocarcinoma; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1995 |
Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines.
Topics: Animals; Apoptosis; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Cells, Cultured; Colonic Neoplasms; DNA, Neoplasm; Endothelium, Vascular; Flow Cytometry; Glomerular Mesangium; HL-60 Cells; Humans; Kinetics; Rats; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Umbilical Veins | 1996 |
Induction of the transcription factor AP-1 in cultured human colon adenocarcinoma cells following exposure to bile acids.
Topics: Activating Transcription Factor 1; Adenocarcinoma; Base Sequence; Bile Acids and Salts; Chenodeoxycholic Acid; Cholagogues and Choleretics; Cholic Acid; Cholic Acids; Colonic Neoplasms; Deoxycholic Acid; DNA Primers; DNA-Binding Proteins; DNA, Neoplasm; Enzyme Activation; Gene Expression Regulation; Genetic Vectors; Humans; Lithocholic Acid; Molecular Sequence Data; NF-kappa B; Podophyllin; Podophyllotoxin; Protein Kinase C; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factors; Tumor Cells, Cultured; Ursodeoxycholic Acid | 1996 |
Overexpression of protein kinase C epsilon is oncogenic in rat colonic epithelial cells.
Topics: Animals; Blotting, Western; Cell Adhesion; Cell Division; Cell Line; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Epithelial Cells; Epithelium; Gene Expression; Genes, ras; Isoenzymes; Mice; Mice, Nude; Protein Kinase C; Rats; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Transplantation, Heterologous | 1996 |
Phorbol ester augments butyrate-induced apoptosis of colon cancer cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Bryostatins; Butyrates; Butyric Acid; Cell Division; Colonic Neoplasms; Drug Interactions; Enzyme Activation; Humans; Kinetics; Lactones; Macrolides; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Activating protein-1 cooperates with phorbol ester activation signals to increase HIV-1 expression.
Topics: Colonic Neoplasms; DNA, Viral; Enzyme Activation; Gene Expression Regulation, Viral; Gene Products, tat; HIV Core Protein p24; HIV Long Terminal Repeat; HIV-1; Humans; Protein Binding; Protein Kinase C; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proviruses; Sp1 Transcription Factor; tat Gene Products, Human Immunodeficiency Virus; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 1996 |
Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells.
Topics: Base Sequence; Cell Differentiation; Cloning, Molecular; Colonic Neoplasms; Cystic Fibrosis Transmembrane Conductance Regulator; DNA, Complementary; Down-Regulation; Humans; Molecular Sequence Data; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
TPA induces transglutaminase C and inhibits cell growth in the colon carcinoma cell line SW620.
Topics: Apoptosis; Cell Division; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Induction; Humans; Protein Kinase C; Tetradecanoylphorbol Acetate; Thymidine; Transglutaminases; Tumor Cells, Cultured | 1997 |
Extracellular adenosine 5' triphosphate involvement in the death of LAK-engaged human tumor cells via P2X-receptor activation.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Apyrase; Calcium Channel Blockers; Cell Death; Cell Line; Colonic Neoplasms; Cytotoxicity, Immunologic; Humans; Killer Cells, Lymphokine-Activated; Receptors, Purinergic P2; Tetradecanoylphorbol Acetate; Thionucleotides; Tumor Cells, Cultured; Verapamil | 1997 |
Protein kinase C activation upregulates intercellular adhesion of alpha-catenin-negative human colon cancer cell variants via induction of desmosomes.
Topics: alpha Catenin; Antigens, Surface; beta Catenin; Cadherins; Cell Adhesion; Cell Size; Colonic Neoplasms; Cytoskeletal Proteins; Desmosomes; Detergents; DNA, Complementary; Humans; Microscopy, Electron; Protein Kinase C; Solubility; Tetradecanoylphorbol Acetate; Tight Junctions; Trans-Activators; Transfection; Tumor Cells, Cultured | 1997 |
Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors.
Topics: Adenocarcinoma; Apoptosis; Butyrates; Butyric Acid; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acids, Volatile; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Blockage of N-myristoylation of HIV-1 gag induces the production of impotent progeny virus.
Topics: Acetaldehyde; Acetals; Cell Line; Colonic Neoplasms; Defective Viruses; Gene Products, gag; HIV Core Protein p24; HIV Reverse Transcriptase; HIV-1; Humans; Myristic Acid; Myristic Acids; Protein Precursors; Protein Processing, Post-Translational; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Fenretinide inhibits phorbol ester-induced cyclooxygenase-2 expression in human colon adenocarcinoma cells.
Topics: Adenocarcinoma; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Fenretinide; Gene Expression Regulation, Neoplastic; Humans; Isoenzymes; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1997 |
Colon carcinoma cells use different mechanisms to escape CD95-mediated apoptosis.
Topics: Antigens, Neoplasm; Apoptosis; Brefeldin A; Carcinoma; Cell Transformation, Neoplastic; Colonic Neoplasms; Cycloheximide; Cyclopentanes; Dactinomycin; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Humans; Immunologic Capping; Interferon-gamma; Intestinal Mucosa; Membrane Glycoproteins; Nucleic Acid Synthesis Inhibitors; Phorbol Esters; Protein Kinase C; Protein Synthesis Inhibitors; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells.
Topics: Apoptosis; Avian Proteins; Base Sequence; CDX2 Transcription Factor; Cell Division; Cell Movement; Ceramides; Colonic Neoplasms; Culture Media, Serum-Free; DNA Primers; Down-Regulation; Genes, bcl-2; Genes, Homeobox; Homeodomain Proteins; HT29 Cells; Humans; Staurosporine; Tetradecanoylphorbol Acetate; Trans-Activators; Transfection | 1998 |
Cloning and expression analysis of a novel salicylate suppressible gene, Hs-CUL-3, a member of cullin/Cdc53 family.
Topics: Amino Acid Sequence; Animals; Base Sequence; Caenorhabditis elegans; Cell Cycle Proteins; Cells, Cultured; Cloning, Molecular; Colonic Neoplasms; Cullin Proteins; Female; Fibroblasts; Gene Expression Regulation; Humans; Male; Molecular Sequence Data; Multigene Family; Organ Specificity; Pregnancy; Recombinant Proteins; RNA, Messenger; Salicylates; Salicylic Acid; Sequence Alignment; Sequence Homology, Amino Acid; Skin; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1998 |
Human colon cancer cells express the functional Fas ligand.
Topics: Apoptosis; Coculture Techniques; Colonic Neoplasms; Fas Ligand Protein; Gene Expression; Humans; Ionomycin; Lymphocyte Activation; Lymphocytes; Membrane Glycoproteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Prostaglandin E2 stimulates IL-8 gene expression in human colonic epithelial cells by a posttranscriptional mechanism.
Topics: Adenocarcinoma; Bucladesine; Colforsin; Colon; Colonic Neoplasms; Cyclic AMP; Dexamethasone; Dinoprostone; Dose-Response Relationship, Immunologic; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Interleukin-8; Intracellular Fluid; Neoplasm Proteins; Protein Processing, Post-Translational; Receptors, Prostaglandin E; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Tissue factor activity of SW-480 human colon adenocarcinoma cells is modulated by thrombin and protein kinase C activation.
Topics: Adenocarcinoma; Coagulants; Colonic Neoplasms; Enzyme Activation; Enzyme Inhibitors; Hemostatics; Humans; Neoplasm Proteins; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Thromboplastin; Tumor Cells, Cultured | 1998 |
Mucin secretion by the human colon cell line LS174T is regulated by bile salts.
Topics: Adenocarcinoma; Animals; Bile Acids and Salts; Colon; Colonic Neoplasms; Dogs; Enzyme Activation; Epithelium; Humans; Mucins; Phorbol 12,13-Dibutyrate; Protein Kinase C; Solutions; Structure-Activity Relationship; Taurochenodeoxycholic Acid; Tetradecanoylphorbol Acetate; Tritium; Tumor Cells, Cultured | 1999 |
Activated Ki-Ras suppresses 12-O-tetradecanoylphorbol-13-acetate-induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells.
Topics: Alleles; Amino Acid Substitution; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Colonic Neoplasms; Culture Media, Serum-Free; Depression, Chemical; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Immediate-Early; Genes, ras; Humans; Indoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Maleimides; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Kinase 4; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Mutation, Missense; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Isoforms; Protein Kinase C; Protein Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Activation of protein kinase C augments butyrate-induced differentiation and turnover in human colonic epithelial cells in vitro.
Topics: Apoptosis; Butyrates; Cell Differentiation; Colonic Neoplasms; DNA Replication; Enzyme Activation; Humans; Interleukin-8; Intestinal Mucosa; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Glycine-extended gastrin exerts growth-promoting effects on human colon cancer cells.
Topics: Animals; Antineoplastic Agents; Binding Sites; Binding, Competitive; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Colonic Neoplasms; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Gastrins; Gene Expression Regulation; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; Meglumine; Mitogen-Activated Protein Kinases; Peptide Fragments; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Rats; Receptors, Cholecystokinin; Recombinant Proteins; Response Elements; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 1999 |
Expression and regulation of the meprin beta gene in human cancer cells.
Topics: Animals; Base Sequence; Cloning, Molecular; Colonic Neoplasms; DNA, Complementary; Gene Expression Regulation, Neoplastic; Humans; Luciferases; Metalloendopeptidases; Mice; Molecular Sequence Data; Promoter Regions, Genetic; RNA, Messenger; Sequence Homology, Nucleic Acid; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1999 |
Distinct protein kinase C isozymes signal mitogenesis and apoptosis in human colon cancer cells.
Topics: Acetamides; Antineoplastic Agents; Apoptosis; Biological Transport; Colonic Neoplasms; Colorectal Neoplasms; Down-Regulation; Enzyme Inhibitors; Ethers, Cyclic; Humans; Indoles; Isoenzymes; Maleimides; Mitosis; Osmolar Concentration; Protein Kinase C; Pyrans; Signal Transduction; Spiro Compounds; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex.
Topics: Antineoplastic Agents; Caffeic Acids; Colonic Neoplasms; Curcumin; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; I-kappa B Kinase; I-kappa B Proteins; Isoenzymes; Membrane Proteins; NF-kappa B; NF-kappaB-Inducing Kinase; Phenylethyl Alcohol; Polyenes; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1999 |
Interleukin-1beta regulates CFTR expression in human intestinal T84 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenocarcinoma; Benzoquinones; Cell Line; Colon; Colonic Neoplasms; Cycloheximide; Cystic Fibrosis Transmembrane Conductance Regulator; Enzyme Inhibitors; Genistein; Humans; Indoles; Interleukin-1; Lactams, Macrocyclic; Maleimides; Neoplasm Proteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Quinones; Rifabutin; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 2000 |
Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure.
Topics: Adenocarcinoma; Anticarcinogenic Agents; beta-Galactosidase; Colonic Neoplasms; Cyclooxygenase 2; Cytokines; Genes, Reporter; Humans; Isoenzymes; Membrane Proteins; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Resorcinols; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 2000 |
Phorbol 12-myristate 13-acetate induces alteration in mucin gene expression and biological properties of colon cancer cells.
Topics: Adenocarcinoma; Antigens, Neoplasm; Carcinogens; Cell Adhesion; Cell Movement; Collagen; Colonic Neoplasms; Drug Combinations; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Laminin; Metalloendopeptidases; Mucin 5AC; Mucin-2; Mucin-3; Mucins; Naphthalenes; Neoplasm Invasiveness; Neoplasm Proteins; Protein Kinase C; Proteoglycans; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-Ras signaling pathway in human colon cancer cells.
Topics: Animals; Biotinylation; Blotting, Northern; Colonic Neoplasms; Culture Media, Conditioned; DNA; DNA, Complementary; Epidermal Growth Factor; Epiregulin; Gene Library; Genes, ras; Humans; Ligands; Mice; Mice, Nude; Oncogene Protein p21(ras); Polymerase Chain Reaction; Precipitin Tests; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Up-Regulation | 2000 |
Induction of cancer cell apoptosis by alpha-tocopheryl succinate: molecular pathways and structural requirements.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Caspase 3; Caspases; Colonic Neoplasms; Colorectal Neoplasms; Enzyme Inhibitors; fas Receptor; Genes, bcl-2; Humans; Isoenzymes; Jurkat Cells; Kinetics; Mice; Mice, Nude; Oligodeoxyribonucleotides, Antisense; Phosphoprotein Phosphatases; Protein Kinase C; Protein Kinase C-alpha; Protein Phosphatase 2; Tetradecanoylphorbol Acetate; Tocopherols; Transplantation, Heterologous; Tumor Cells, Cultured; Vitamin E | 2001 |
Cancer prevention by natural carotenoids.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; beta Carotene; Carotenoids; Colonic Neoplasms; Cryptoxanthins; Disease Models, Animal; Fruit; Humans; Lutein; Lycopene; Methylnitrosourea; Mice; Rats; Rats, Inbred F344; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vegetables; Xanthophylls; Zeaxanthins | 2000 |
The CEACAM1-L Ser503 residue is crucial for inhibition of colon cancer cell tumorigenicity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Antigens, CD; Antigens, Differentiation; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoembryonic Antigen; Carcinogenicity Tests; Carcinoma; Cell Adhesion Molecules; Colonic Neoplasms; Cyclic AMP; Enzyme Inhibitors; Epithelial Cells; Female; Humans; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Naphthalenes; Point Mutation; Protein Kinase C; Serine; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides; Tumor Cells, Cultured | 2001 |
Calcium-dependent interleukin-8 gene expression in T84 human colonic epithelial cells.
Topics: Adenocarcinoma; Calcimycin; Calcineurin; Calcium; Colon; Colonic Neoplasms; Dose-Response Relationship, Drug; Epithelial Cells; Gene Expression; Humans; Interleukin-8; Ionophores; Kinetics; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Thapsigargin; Transcription, Genetic; Tumor Cells, Cultured | 2001 |
Activation of the Wnt pathway interferes with serum response element-driven transcription of immediate early genes.
Topics: Adenosine Triphosphate; Animals; Cell Line; Chlorocebus aethiops; Colonic Neoplasms; COS Cells; DNA Primers; DNA-Binding Proteins; Early Growth Response Protein 1; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; Genes, jun; Genes, Reporter; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Immediate-Early Proteins; Luciferases; Mice; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Wnt Proteins; Wnt1 Protein; Zebrafish Proteins | 2002 |
Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Apoptosis; Cell Division; Colonic Neoplasms; Cyclooxygenase 2; Free Radicals; Humans; Isoenzymes; Membrane Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Sesquiterpenes; Superoxides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2002 |
Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B.
Topics: Binding Sites; Cell Line; Cell Nucleus; Colonic Neoplasms; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genes, Dominant; Humans; Luciferases; Mitogen-Activated Protein Kinases; Models, Biological; Mucin-2; Mucins; Mutation; NF-kappa B; Promoter Regions, Genetic; Protein Kinase C; ras Proteins; RNA; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured; Up-Regulation | 2002 |
Induction of ornithine decarboxylase in normal and protein kinase C--depleted human colon carcinoma cells.
Topics: Adenocarcinoma; Colonic Neoplasms; DNA, Neoplasm; Enzyme Induction; Humans; Ornithine Decarboxylase; Protein Kinase C; Radioimmunoassay; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Modulation of superoxide production from murine macrophages by the antitumour agent flavone acetic acid and xanthenone acetic acid analogues.
Topics: Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Flavonoids; Macrophages; Mice; Mice, Inbred C3H; Necrosis; Superoxides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Xanthenes | 1992 |
Ion transport in colon cancer cell cultures studied by X-ray microanalysis.
Topics: Biological Transport; Chlorides; Colonic Neoplasms; Cyclic AMP; Electron Probe Microanalysis; Elements; Humans; Potassium; Sodium; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
The fast release of mucin secretion from human colonic cells induced by Entamoeba histolytica is dependent on contact and protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenocarcinoma; Alkaloids; Animals; Calcium; Carbohydrate Sequence; Cell Adhesion; Colon; Colonic Neoplasms; Entamoeba histolytica; Enzyme Activation; Humans; Intestinal Mucosa; Isoquinolines; Lectins; Membrane Glycoproteins; Mice; Mice, Nude; Molecular Sequence Data; Mucins; Neoplasm Proteins; Piperazines; Protein Kinase C; Protozoan Proteins; Secretory Rate; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Hsp60/chaperonin gene expression and differentiation of human colon adenocarcinoma and multipotent leukaemic cells.
Topics: Adenocarcinoma; Cell Differentiation; Chaperonins; Colonic Neoplasms; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Library; Glucose; Heat-Shock Proteins; Humans; Leukemia, Promyelocytic, Acute; Mitochondria; Molecular Sequence Data; Proteins; Restriction Mapping; RNA, Neoplasm; Tetradecanoylphorbol Acetate | 1992 |
Expression of the cystic fibrosis transmembrane conductance regulator gene can be regulated by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Cell Line; Colonic Neoplasms; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Isoquinolines; Kinetics; Membrane Proteins; Piperazines; Protein Kinase C; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1992 |
Role of protein kinase C in transforming growth factor-beta 1 induction of carcinoembryonic antigen in human colon carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoembryonic Antigen; Colonic Neoplasms; Humans; Isoquinolines; Naphthalenes; Piperazines; Polycyclic Compounds; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured | 1992 |
Effect of modulation of protein kinase C on the cAMP-dependent chloride conductance in T84 cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Biological Transport; Chloride Channels; Chlorides; Colonic Neoplasms; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Diglycerides; Down-Regulation; Electric Conductivity; Fluorescence; Fluorescent Dyes; Humans; Ionomycin; Membrane Proteins; Protein Kinase C; Protein Kinases; Quinolinium Compounds; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Bile acids, non-phorbol-ester-type tumor promoters, stimulate the phosphorylation of protein kinase C substrates in human platelets and colon cell line HT29.
Topics: Bile Acids and Salts; Blood Platelets; Calcium; Carcinogens; Colonic Neoplasms; Deoxycholic Acid; Enzyme Activation; Humans; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Regulation of apical Cl- conductance and basolateral K+ conductances by phorbol esters in HT-29cl.19A cells.
Topics: Calcium; Carcinoma; Cell Membrane; Chlorides; Colforsin; Colonic Neoplasms; Electric Conductivity; Humans; Phorbol 12,13-Dibutyrate; Potassium; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
The modulation of growth by HMBA in PKC overproducing HT29 colon cancer cells.
Topics: Acetamides; Cell Division; Colonic Neoplasms; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Differential expression of two classes of lck transcripts upon phorbol ester treatment of human leukemic T cells.
Topics: Cell Line; Cells, Cultured; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Kinetics; Leukemia; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Oncogene Proteins, Viral; Oncogenes; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein-Tyrosine Kinases; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1991 |
Regulation of calcium-activated potassium efflux by neurotensin and other agents in HT-29 cells.
Topics: Adenocarcinoma; Adenosine Triphosphate; Barium; Calcium; Carbachol; Cell Line; Colonic Neoplasms; Humans; Ionomycin; Kinetics; Neurotensin; Potassium; Potassium Channels; Rubidium; Tetradecanoylphorbol Acetate; Tetraethylammonium; Tetraethylammonium Compounds | 1991 |
In vitro model for intrinsic drug resistance: effects of protein kinase C activators on the chemosensitivity of cultured human colon cancer cells.
Topics: Antineoplastic Agents; Colonic Neoplasms; Diglycerides; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Enzyme Activation; Humans; Phorbol 12,13-Dibutyrate; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vincristine | 1991 |
The T84 human colonic adenocarcinoma cell line produces mucin in culture and releases it in response to various secretagogues.
Topics: Adenocarcinoma; Calcimycin; Carbachol; Cell Line; Cholera Toxin; Colonic Neoplasms; Cystic Fibrosis; Histamine; Humans; Immunodiffusion; Immunoenzyme Techniques; Intestine, Small; Microscopy, Electron; Mucins; Prostaglandins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1990 |
Phosphofructokinase 2 and glycolysis in HT29 human colon adenocarcinoma cell line. Regulation by insulin and phorbol esters.
Topics: Adenocarcinoma; Colonic Neoplasms; Glycolysis; Humans; Insulin; Kinetics; Lactates; Phosphofructokinase-2; Phosphotransferases; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Agonist-induced desensitization of cholinergically stimulated phosphoinositide breakdown is independent of endogenously activated protein kinase C in HT-29 human colon carcinoma cells.
Topics: Carbachol; Colonic Neoplasms; Enzyme Activation; GTP-Binding Proteins; Humans; Hydrolysis; Inositol; Ionomycin; N-Methylscopolamine; Phosphatidylinositols; Phosphorylation; Protein Kinase C; Receptors, Muscarinic; Scopolamine Derivatives; Sodium Fluoride; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Type C Phospholipases | 1990 |
Differing roles of protein kinase C on the antiproliferative effects of tumor necrosis factor alpha and beta on LoVo cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Colonic Neoplasms; Dose-Response Relationship, Drug; Humans; Isoquinolines; Lymphotoxin-alpha; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1990 |
Protein kinase C activation selectively increases mRNA levels for one of the regulatory subunits (RI alpha) of cAMP-dependent protein kinases in HT-29 cells.
Topics: Blotting, Northern; Cell Line; Colonic Neoplasms; DNA Probes; Enzyme Activation; Humans; Macromolecular Substances; Protein Kinase C; Protein Kinases; RNA, Messenger; Tetradecanoylphorbol Acetate | 1990 |
Phorbol esters activate proteoglycan metabolism in human colon cancer cells en route to terminal differentiation.
Topics: Bryostatins; Cell Differentiation; Cell Division; Colonic Neoplasms; Cycloheximide; Diglycerides; DNA Replication; Enzyme Activation; Heparitin Sulfate; Humans; Isoenzymes; Lactones; Macrolides; Membrane Proteins; Neoplasm Proteins; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Vasoactive intestinal peptide stimulates active K+ transport and Na(+)-K(+)-Cl- cotransport in HT-29 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenocarcinoma; Amiloride; Biological Transport; Bumetanide; Carrier Proteins; Cell Line; Chlorides; Colonic Neoplasms; Humans; Isoquinolines; Kinetics; Norepinephrine; Ouabain; Piperazines; Potassium; Protein Kinase C; Sodium-Potassium-Chloride Symporters; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vasoactive Intestinal Peptide; Yohimbine | 1990 |
Overexpression of protein kinase C in HT29 colon cancer cells causes growth inhibition and tumor suppression.
Topics: Animals; Cell Division; Cell Line; Colonic Neoplasms; Gene Expression; Genetic Vectors; Humans; Kinetics; Mice; Mice, Nude; Neoplasm Transplantation; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured | 1990 |
Evidence for a modulatory role of protein kinase C on glycosaminoglycan biosynthesis during the spontaneous differentiation of Caco-2 cells.
Topics: Biological Transport; Cell Differentiation; Cell Membrane; Colonic Neoplasms; Cytosol; Diglycerides; Enzyme Activation; Glycosaminoglycans; Humans; Protein Kinase C; Sulfates; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Induction of the expression of differentiation-related antigens on human colon carcinoma cells by stimulating protein kinase C.
Topics: Antibodies, Monoclonal; Antigens, Differentiation; Antigens, Neoplasm; Autoradiography; Carcinoma; Cell Line; Cell Transformation, Neoplastic; Colonic Neoplasms; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Immunoenzyme Techniques; Microscopy, Electron; Protein Kinase C; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Modulation of carcinoembryonic antigen release by HT-29 colon carcinoma line in the presence of different agents.
Topics: Acetamides; Azacitidine; Butyrates; Butyric Acid; Carcinoembryonic Antigen; Cell Differentiation; Colonic Neoplasms; Drug Synergism; Formamides; Humans; Tetradecanoylphorbol Acetate; Tretinoin | 1987 |
Binding of metastatic colon carcinoma cells to liver macrophages.
Topics: Animals; Carcinoma; Cell Adhesion; Cell Line; Colchicine; Colonic Neoplasms; Cytochalasin B; Cytotoxicity, Immunologic; Egtazic Acid; Kupffer Cells; Liver Neoplasms; Macrophages; Male; Monosaccharides; Peritoneal Cavity; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Trypsin | 1989 |
Neurotensin stimulates inositol trisphosphate-mediated calcium mobilization but not protein kinase C activation in HT29 cells. Involvement of a G-protein.
Topics: Adenocarcinoma; Aminoquinolines; Calcium; Cell Line; Cell Membrane; Colonic Neoplasms; Diglycerides; Enzyme Activation; Fluorescent Dyes; Humans; Inositol 1,4,5-Trisphosphate; Ionomycin; Kinetics; Neurotensin; Protein Kinase C; Receptors, Neurotensin; Receptors, Neurotransmitter; Ribonucleotides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Tyrosine phosphorylation of a Mr 63,000 protein induced by an endogenous mitogen in human colon carcinoma cells, but not in normal colonocytes.
Topics: Carcinoma; Colon; Colonic Neoplasms; Diglycerides; Glycerides; Humans; Membrane Proteins; Mitogens; Molecular Weight; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1989 |
Characterization and possible mechanisms of alpha 2-adrenergic receptor-mediated sensitization of forskolin-stimulated cyclic AMP production in HT29 cells.
Topics: Adenocarcinoma; Adenylate Cyclase Toxin; Blood Platelets; Carrier Proteins; Cell Line; Colforsin; Colonic Neoplasms; Cyclic AMP; Cycloheximide; Enzyme Activation; Humans; Kinetics; Norepinephrine; Pertussis Toxin; Protein Kinase C; Receptors, Adrenergic, alpha; Sodium; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate; Vasoactive Intestinal Peptide; Virulence Factors, Bordetella | 1988 |
Fecal diglycerides as selective endogenous mitogens for premalignant and malignant human colonic epithelial cells.
Topics: Adenoma; Colon; Colonic Neoplasms; Diglycerides; Epithelium; Feces; Glycerides; Humans; Mitosis; Precancerous Conditions; Stearic Acids; Tetradecanoylphorbol Acetate | 1989 |
Activation of phosphatidylinositol turnover by neurotensin receptors in the human colonic adenocarcinoma cell line HT29.
Topics: Adenocarcinoma; Cell Line; Colonic Neoplasms; Cyclic AMP; Cyclic GMP; Humans; Inositol Phosphates; Kinetics; Neurotensin; Phosphatidylinositols; Receptors, Neurotensin; Receptors, Neurotransmitter; Tetradecanoylphorbol Acetate | 1986 |
Phorbol ester induces loss of VIP stimulation of adenylate cyclase and VIP-binding sites in HT29 cells.
Topics: Adenocarcinoma; Adenylyl Cyclases; Binding Sites; Cell Line; Cell Membrane; Colonic Neoplasms; Cyclic AMP; Humans; Phorbol Esters; Tetradecanoylphorbol Acetate; Vasoactive Intestinal Peptide | 1987 |
Enhancement of production of superoxide anion by human monocytes exposed to products of HT 29 human colonic adenocarcinoma cell line.
Topics: Adenocarcinoma; Cell Line; Colonic Neoplasms; Culture Media; Humans; Kinetics; Lymphokines; Monocytes; Superoxides; Tetradecanoylphorbol Acetate | 1987 |
Modulation of HT-29 human colonic cancer cell differentiation with calmidazolium and 12-O-tetradecanoylphorbol-13-acetate.
Topics: Antigens, Neoplasm; Calmodulin; Calmodulin-Binding Proteins; Cell Differentiation; Cell Division; Colonic Neoplasms; Cytoskeleton; Fluorescent Antibody Technique; Humans; Imidazoles; Phosphorylation; Sucrase-Isomaltase Complex; Tetradecanoylphorbol Acetate | 1988 |
Tissue culture model of adenoma invasion implicating diglycerides from fecal fat degradation as promoting agents.
Topics: Adenoma; Animals; Colonic Neoplasms; Culture Techniques; Dietary Fats; Diglycerides; Feces; Glycerides; Microscopy, Phase-Contrast; Neoplasm Invasiveness; Tetradecanoylphorbol Acetate | 1988 |
Influence of dispase and angiogenesis factors on the growth of human xenografts.
Topics: Alprostadil; Angiogenesis Inducing Agents; Animals; Colonic Neoplasms; Endopeptidases; Growth Substances; Humans; Male; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Tetradecanoylphorbol Acetate; Transplantation, Heterologous | 1988 |
Bryostatin 1 antagonizes the terminal differentiating action of 12-O-tetradecanoylphorbol-13-acetate in a human colon cancer cell.
Topics: Bryostatins; Cell Differentiation; Cell Division; Cell Line; Colonic Neoplasms; DNA Replication; Humans; Lactones; Macrolides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1988 |
The bile acid analog fusidic acid can replace phosphatidylserine in the activation of protein kinase C by 12-O-tetradecanoylphorbol-13-acetate in vitro.
Topics: Animals; Bile Acids and Salts; Calcium; Colon; Colonic Neoplasms; Enzyme Activation; Fusidic Acid; Phosphatidylserines; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1988 |
Tissue culture model of adenoma invasion.
Topics: Adenoma; Benzamidines; Carcinoma; Colonic Neoplasms; Culture Techniques; Humans; Models, Biological; Neoplasm Invasiveness; Tetradecanoylphorbol Acetate; Urokinase-Type Plasminogen Activator | 1987 |
Altered levels of protein kinase C and Ca2+-dependent protein kinases in human colon carcinomas.
Topics: Calcium; Carcinoma; Colon; Colonic Neoplasms; Humans; Intestinal Mucosa; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate | 1987 |
Enhancement of fibroblast growth factor-induced diacylglycerol formation and protein kinase C activation by colon tumor-promoting bile acid in Swiss 3T3 cells. Different modes of action between bile acid and phorbol ester.
Topics: Animals; Cell Line; Cell-Free System; Colonic Neoplasms; Deoxycholic Acid; Diglycerides; Drug Synergism; Enzyme Activation; Fibroblast Growth Factors; Glycerides; Mice; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |