tetradecanoylphorbol acetate has been researched along with Breast Cancer in 326 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 25 (7.67) | 18.7374 |
1990's | 147 (45.09) | 18.2507 |
2000's | 68 (20.86) | 29.6817 |
2010's | 83 (25.46) | 24.3611 |
2020's | 3 (0.92) | 2.80 |
Authors | Studies |
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Carmody, LC; Dandapani, S; Donckele, E; Feng, Y; Fernandez, C; Germain, AR; Gupta, PB; Lander, ES; Morgan, B; Munoz, B; Nag, PP; Palmer, M; Perez, JR; Schreiber, SL; Verplank, L | 1 |
Hong, OY; Jang, HY; Jung, SH; Kim, JS; Lee, YR; Youn, HJ | 1 |
Baek, J; Kim, S; Lee, KS; Nam, GS; Nam, KS | 1 |
Jung, SH; Kang, SY; Kim, JM; Kim, JS; Lee, YR; Noh, EM; Park, BH; Park, J; Song, HK; Youn, HJ | 1 |
Bae, SY; Jeong, Y; Jung, SP; Kim, S; You, D | 1 |
Chew, EH; Chui, WK; Gan, FF; Hadadi, E; Karuppasamy, M; Ng, HL; Ong, SM; Seah, W; Wong, SC; Yeap, WH; Zhang, R | 1 |
Gobe, GC; Morais, C; Song, W; Thakor, P; Vesey, DA | 1 |
Bak, Y; Kim, SJ; Oh, SR; Pham, TH; Ryu, HW; Yoon, DY | 1 |
Chao, CY; Chen, HW; Hsu, YT; Li, CC; Lii, CK; Liu, KL; Lu, CY | 1 |
Amaral, L; Engi, H; Hamilton, G; Hohmann, J; Maoka, T; Molnar, J; Mucsi, I; Olszewski, U; Suzuiki, N; Tokuda, H; Vasas, A | 1 |
Kang, JW; Kim, JH; Lee, DH; Oh, SR; Park, SH; Song, HH; Yoon, DY | 1 |
Cheng, H; Dai, S; Deng, K; Fu, C; Li, Y; Meng, J; Meng, Y; Shen, A; Wang, G; Wang, H; Wei, D | 1 |
Prough, RA; Samuelson, DJ; Xu, X | 1 |
Lee, KS; Nam, KS; Shin, JS | 1 |
Chae, HS; Chung, EY; Hwang, BM; Jeong, YJ; Jung, SH; Kim, JS; Lee, YR; Noh, EM; Youn, HZ; Yu, HN | 1 |
Haidari, M; Wakame, K; Zhang, W | 1 |
Jin, ML; Kim, YH; Lee, SJ; Park, G; Park, SY | 1 |
Bae, SY; Gil, WH; Han, J; Jeon, M; Jung, T; Kim, J; Kim, S; Kim, SW; Lee, J; Lee, JE; Lee, SK; Nam, SJ; Oh, SJ | 1 |
Chen, H; Ding, F; He, H; Li, L; Li, S; Liu, Z; Ma, J; Qu, C; Shi, Y; Xu, C; Zhan, Y; Zhang, S | 1 |
Chang, L; Drachenberg, DM; Klos, KS; Leung, CT; Luxton, GW; Schwertfeger, KL; Warmka, JK; Wattenberg, EV | 1 |
Hwang, HY; Hwang, JK; Jung, SH; Kim, HJ; Kim, JM; Kim, JS; Kim, MS; Kwon, KB; Lee, YR; Noh, EM; Ryu, DG; You, YO; Youn, HJ; Yu, HN | 1 |
Cha, YN; Kim, DH; Kim, EH; Kim, HN; Kundu, JK; Lee, MH; Na, HK; Surh, YJ | 1 |
Jang, EH; Jang, SY; Jeong, SY; Kim, JH; Lee, JK | 1 |
Chen, X; Tan, W; Wang, Y; Zhong, Z | 1 |
Chun, SY; Lee, DH; Lee, KS; Nam, KS | 1 |
Hwang, JK; Kim, HJ; Kim, HR; Kim, JM; Kim, MS; Kim, YC; Kwon, KB; Lee, DS; Lee, YR; Moon, BS; Oh, H; Park, YJ; Rhee, YJ; Ryu, DG; Yang, SH; Yun, JM | 1 |
Im, NK; Jang, WJ; Jeong, CH; Jeong, GS | 1 |
Dong, S; Guo, D; Li, L; Qi, B; Wang, Y; Yu, M; Yuan, D; Zhang, C | 1 |
Blagosklonny, MV; Leontieva, OV | 1 |
Hung, HC; Liao, YF; Liu, GY; Tzeng, YM | 1 |
Chen, KC; Chen, YC; Cheng, CH; Lee, TH; Lee, WT; Lin, CW | 1 |
Jang, SW; Kang, H; Pak, JH; Shim, S | 1 |
Hong, OY; Jung, SH; Kim, JS; Lee, YR; Noh, EM; Youn, HJ | 1 |
Choi, KB; Hong, OY; Kim, HR; Kim, JM; Kim, JS; Kim, MS; Kwon, KB; Lee, YR; Noh, EM; Park, SH; Park, YJ; So, HS; Song, HK; Yang, SH; You, YO; Youn, HJ | 1 |
Brandi, G; Bucchini, A; De Santi, M; Fanelli, M; Giamperi, L; Giomaro, G; Schiavano, GF | 1 |
Bao, R; Bechill, J; Bindokas, VP; Faber, PW; Lingen, MW; Spiotto, MT; Zhong, R | 1 |
Kim, HR; Kim, JM; Kim, MS; Kwon, KB; Lee, GS; Lee, M; Lee, YR; Moon, HC; Noh, EM; Song, HK; Yang, SH | 1 |
Chun, SY; Kim, S; Kwon, YS; Nam, KS | 1 |
Abel, PW; Jiang, H; Scofield, MA; Tu, Y; Wei, T; Wong, CY; Xie, Y | 1 |
Chang, JW; Chen, HW; Chen, JJ; Li, CC; Lii, CK; Liu, KL; Liu, SH; Tsai, CH; Wang, TS; Yeh, SL | 1 |
Yi, C; Zhong, Y | 1 |
Cao, H; Chen, T; Dang, W; Huang, Y; Li, K; Pang, X; Su, M; Tang, C; Tang, H; Wang, H; Wang, L; Wei, L | 1 |
Jiang, W; Wang, A; Wang, L; Wang, Y; Wu, B; Zhou, H; Zhou, Q | 1 |
Chen, YC; Hou, WC; Juan, SH; Ko, CH; Lin, CW; Shen, SC; Wang, LM | 1 |
Choe, JH; Choi, JH; Kim, JH; Kim, JS; Kim, S; Kim, WW; Lee, JE; Lee, SK; Lim, HI; Nam, SJ; Yang, JH | 1 |
Anelli, V; Grabowski, GA; Hannun, YA; Jenkins, RW; Kitatani, K; Obeid, LM; Sheldon, K; Sun, Y | 1 |
Anelli, V; Grabowski, GA; Hannun, YA; Jenkins, RW; Kitatani, K; Obeid, LM; Rajagopalan, V; Sheldon, K; Sun, Y | 1 |
An, D; Du, J; Hu, F; Yang, S; Yuan, W; Zhai, C; Zhu, T | 1 |
Chung, WY; Hwang, YS; Park, HJ; Park, KK; Park, SK; Seo, JY | 1 |
Heakal, Y; Kester, M | 1 |
Brown, KA; Hunger, NI; McInnes, KJ; Oakhill, JS; Simpson, ER; Steinberg, GR | 1 |
Choe, JH; Hur, SM; Kim, JH; Kim, JS; Kim, S; Kim, SH; Kim, WW; Lee, JE; Lee, SK; Nam, SJ; Yang, JH | 1 |
Hwang, JT; Lee, YK; Park, OJ; Shin, JI | 1 |
Huot, ME; Richard, S; Vogel, G | 1 |
Bae, YS; Chang, YC; Cho, HJ; Chung, IK; Han, SM; Jeong, YJ; Lee, KG; Park, KK; Park, YY; Yeo, JH | 1 |
Lau, GT; Leung, LK; Ye, L | 1 |
Chung, EY; Han, JH; Jeong, YJ; Jung, JY; Jung, SH; Kim, BS; Kim, JS; Lee, SH; Lee, YR; Noh, EM; Youn, HJ | 1 |
Miyamoto, S; Nakashima, M; Sonoda, K; Wake, N | 1 |
Chung, E; Cui, Z; Kim, KM; Kim, KS; Kim, SJ; Kwak, YJ; Lee, JH; Lee, YC; Yao, L | 1 |
Kim, DH; Liu, D; Na, HK; Park, JM; Surh, YJ | 1 |
Benabbou, N; Faussat, AM; Hatmi, M; Karroum, A; Mirshahi, M; Mirshahi, P; Soria, J; Therwath, A | 1 |
Behravan, J; Elahian, F; Kalalinia, F | 1 |
Lee, LH; Moh, MC; Shen, S; Zhang, T | 1 |
Choe, JH; Hur, SM; Kim, JH; Kim, JS; Kim, S; Kim, SH; Lee, HS; Lee, JE; Lee, SK; Nam, SJ; Shin, I; Yang, JH | 1 |
Drabsch, Y; Gonda, TJ; Robert, RG | 1 |
Leung, LK; Yi Lau, GT | 1 |
Chew, EH; Chui, WK; Ling, H; Tan, SH; Yang, H | 1 |
Huang, H; Lau, GT; Leung, LK; Lin, SM | 1 |
Goding, CR; Leaner, VD; Mowla, S; Pinnock, R; Prince, S | 1 |
Choi, BD; Ha, YL; Jang, WJ; Kim, JO; Kim, YS; Kong, IK; Rakib, MA | 1 |
Choi, YH; Kim, GY; Kim, WJ; Moon, DO; Moon, SK | 1 |
Han, JH; Hur, H; Hwang, JK; Jung, JY; Jung, SH; Kim, BS; Kim, JM; Kim, JS; Lee, SH; Lee, YR; Noh, EM; Oh, HJ; Park, BH; Park, CS; Park, JW; Youn, HJ | 1 |
Chand, AL; Clyne, CD; Herridge, KA; Howard, TL; Simpson, ER | 1 |
Haas, TA; Li, X; Liu, Y; Taherian, A | 1 |
Bajer, MM; Baker, AR; Blees, JS; Brüne, B; Colburn, NH; Eifler, LK; Milke, L; Rübsamen, D; Schmid, T; Schulz, K; Weigert, A | 1 |
de Paula, CA; Jochum, M; Karow, M; Mayer, B; Nakahata, AM; Neth, P; Oliva, ML; Ries, C; Sampaio, MU | 1 |
Jang, SW; Kang, H; Kim, Y; Ko, J | 1 |
Bae, HS; Han, SI; Jeon, HM; Ju, MK; Kang, HS; Kim, CH; Lee, SY; Lim, SC; Park, HG | 1 |
Jang, SW; Jang, SY; Ko, J | 1 |
Han, J; Kim, S; Lee, JE; Nam, SJ; Yang, JH | 1 |
Elson, A; Nunes-Xavier, CE; Pulido, R | 1 |
Bak, Y; Chung, IM; Kim, JH; Kim, MS; Yoon, DY | 1 |
Choe, JH; Choi, MY; Han, J; Jung, SP; Kim, J; Kim, JH; Kim, JS; Kim, S; Lee, J; Lee, JE; Lee, SK; Nam, SJ | 1 |
Choi, KC; Jang, SW; Kang, H; Ko, J; Lee, M; Shin, DM | 1 |
Kim, KM; Kim, KS; Lee, JH; Lee, YC; Moon, HI; Yu, HY | 1 |
Faussat, AM; Hatmi, M; Karroum, A; Mirshahi, M; Mirshahi, P; Therwath, A | 1 |
Liao, YF; Rao, YK; Tzeng, YM | 1 |
Kim, Y; Kim, YH; Lee, SJ; Park, SY | 2 |
Hwang, BM; Hwang, JK; Jung, SH; Kim, BS; Kim, JM; Kim, JS; Kwon, KB; Lee, SH; Lee, SJ; Lee, YR; Noh, EM; You, YO; Youn, HJ | 1 |
Behravan, J; Elahian, F; Hassani, M; Kalalinia, F; Kasaeeian, J | 1 |
Azorsa, DO; Byron, SA; Hostetter, G; Kim, S; Little, TH; Min, E; Tapia, C; Thal, TS; Watanabe, AT | 1 |
Cheng, YF; Lee, YS; Shi, MD; Shih, YW; Tsai, LY | 1 |
Kim, JH; Kim, Y; Lee, SJ; Lee, YJ; Park, SY | 1 |
Chung, EY; Hur, H; Jung, SH; Kim, JS; Lee, YR; Noh, EM; Youn, HJ | 1 |
Chao, CY; Chen, HW; Li, CC; Lii, CK; Lin, LL; Liu, KL; Lu, CY | 1 |
Chung, EY; Hwang, BM; Hwang, JK; Jung, SH; Kim, JM; Kim, JS; Kim, MS; Kwon, KB; Lee, SJ; Lee, YR; Noh, EM; You, YO; Youn, HJ | 1 |
Han, J; Jung, SP; Kim, JH; Kim, JS; Kim, S; Lee, JE; Nam, SJ; Oh, SJ | 1 |
Beatty, P; Brooks, MN; Ellis, L; Go, VL; Heber, D; Liu, C; Liu, W; Sartippour, MR; Shao, ZM; Zhang, L | 1 |
Chapel, A; Garin, J; Journet, A; Kieffer, S; Roux, F | 1 |
Andreocci, L; Battaglia, A; Coscarella, A; Fattorossi, A; Maggiano, N; Malinconico, P; Parente, D; Perillo, A; Pierelli, L; Scambia, G; Stoler, A | 1 |
Esen, M; Krappmann, D; Mordmüller, B; Scheidereit, C; Wegener, E | 1 |
Dandachi, N; Doppelmayr, H; Fellner, T; Hauser-Kronberger, C; Moré, E; Obrist, P; Paulweber, B; Sandhofer, F | 1 |
Brenchley, PE; Ralph, S; Ray, DW; Soden, J; Stevens, A | 1 |
Braig, M; Dittmer, J; Hauser, CA; Lindemann, RK; Nordheim, A | 1 |
Francescutti, V; Gauthier, ML; Ly, J; O'Day, DH; Torretto, C | 1 |
Cheng, CK; Chow, BK; Leung, PC | 1 |
Richards, JS; Sriraman, V | 1 |
Dosescu, J; Moin, K; Sameni, M; Sloane, BF | 1 |
Danø, K; Gårdsvoll, H; Hansen, LV; Jensen, ON; Lund, LR; Nielsen, BS; Ploug, M | 1 |
Badia, E; Duchesne, MJ; Oliva, J; Pons, M; Semlali, A | 1 |
Mauro, LJ; Warmka, JK; Wattenberg, EV | 1 |
Baj, G; Cannas, M; Renò, F; Surico, N | 1 |
Cardoso, F; Gonze, I; Haibe-Kains, B; Hennuy, B; Lacroix, M; Laes, JF; Lallemand, F; Leclercq, G; Piccart, M; Sotiriou, C | 1 |
Heo, KS; Ko, JH; Lee, SJ; Lim, K; Lim, KT | 1 |
Fujii, T; Kuwano, M; Shirouzu, K; Tayama, K; Yamana, H; Yokoyama, G | 1 |
Annan, RS; Hall, C; Li, Z; Lim, L; Marler, KJ; McNulty, DE; Sacks, DB | 1 |
Adiseshaiah, P; Kalvakolanu, DV; Peddakama, S; Reddy, SP; Zhang, Q | 1 |
De Servi, B; Hermani, A; Mayer, D; Medunjanin, S | 1 |
Danova, M; Ferrari, S; Malugani, F; Porta, C; Riccardi, A; Rovati, B | 1 |
Huang, Q; Ong, CN; Rose, P; Whiteman, M | 1 |
Bowden, GT; Degner, SC; Kemp, MQ; Romagnolo, DF | 1 |
Borst, J; de Vries, E; López-Rivas, A; Ortiz-Ferrón, G; Robledo, G; Tait, SW | 1 |
Toker, A; Yiu, GK | 1 |
Fujii, T; Koike, K; Kuwano, M; Nakamura, AM; Shirouzu, K; Yamana, H; Yokoyama, G | 1 |
Davie, JR; Espino, PS; He, S; Li, L; Yu, J | 1 |
Kim, J; Kim, SH | 1 |
Lau, TY; Leung, LK | 1 |
Müller, J; Nieber, M; Robitzki, AA; Rothermel, A; Schmidt, M; Wolf, P | 1 |
Chang, YC; Im, HG; Jeong, YJ; Kim, CH; Lee, IS; Lee, SO | 1 |
Suyama, H; Ushijima, N; Yamamoto, N | 1 |
Capurro, E; Fortino, V; Maioli, E; Sacchi, G; Torricelli, C; Valacchi, G | 1 |
Chen, YC; Hou, WC; Lin, CW; Shen, SC; Yang, LY | 1 |
Collins, M; McKay, I; Rozengurt, E; Taylor-Papadimitriou, J | 1 |
Malcolm, DE; Skinnider, LF | 1 |
Brown, BL; Corbett, NR; Dawson, CH; Dobson, PR; Dunford, JE; Varley, CL | 1 |
Smith, CD; Zilfou, JT | 1 |
Chorváth, B; Duraj, J; Grófová, M; Hunáková, L; Sedlák, J | 1 |
Cardinale, I; Kikuchi, T; Krueger, JG; Tamm, I | 1 |
Danielsen, M; Garcia-Morales, P; Katz, D; Martin, MB; Pierce, M; Saceda, M; Solomon, HB; Stoica, A; Zhang, S | 1 |
Bryant, WO; Chen, J; Cook, PP; de Vente, JE; Fletcher, DJ; Kukoly, CA; Lozano, G; Parker, PJ; Pettit, GJ; Posekany, KJ | 1 |
Baird, WM; Boyd, GW; Coombs, MM | 1 |
Dickson, RB; Johnson, GR; Martínez-Lacaci, I; Normanno, N; Plowman, GD; Saceda, M; Salomon, DS | 1 |
Andreasen, PA; Chan, L; Christensen, A; Ellgaard, L; Heegaard, CW; Kjøller, L; Madsen, B; Oka, K; Simonsen, AC | 1 |
Bona, BJ; Borror, KC; DeFranco, DB; Moyer, ML; Nordeen, SK | 1 |
Brouty-Boyé, D; Spanakis, E | 1 |
Beery, R; Geier, A; Haimsohn, M; Hemi, R; Karasik, A; Malik, Z; Weiss, C | 1 |
Chubb, CH; Fujiki, H; Glesne, D; Huberman, E; Kiguchi, K | 1 |
Astruc, ME; Bali, P; Chabret, C; Gagne, D; Pons, M | 1 |
Beery, R; Geier, A; Haimsohn, M; Hemi, R; Karasik, A; Malik, Z | 1 |
Antoniotti, S; Dati, C; De Bortoli, M; Hynes, NE; Maggiora, P; Taverna, D | 1 |
Israel, L; Mainguene, C; Nehme, A; Planchon, P; Prevost, G; Salle, V; Spanakis, E; Starzec, AB; Valette, A; Veber, N | 1 |
Anderson, WB; Kiss, Z; Tomono, M | 1 |
Chang, GG; Chang, TC; Chiao, CH; Hung, MW; Tsai, LC; Wang, JK | 1 |
Bueno, J; Maiti, SN; Palao-Marco, FL; Pulyaeva, H; Thompson, EW; Tirgari, RH; Yu, M | 1 |
Phang, JM; Welsh, CJ; Yeh, GC | 1 |
Blobe, GC; Fabbro, D; Fine, RL; Hannun, YA; Khan, WA; Obeid, LM; Sachs, CW; Stabel, S; Wetsel, WC | 1 |
Bradshaw, TD; Gescher, A; Pettit, GR; Stanwell, C | 1 |
Stein, U; Wunderlich, V | 1 |
Andreasen, PA; Christensen, L; Knudsen, H; Olesen, T; Riccio, A; Ungaro, P | 1 |
Demura, H; Dobashi, I; Horiba, N; Ohmori, N; Suda, T; Tozawa, F; Yamada, M; Yamakado, M | 1 |
Beck, CA; Edwards, DP; Nordeen, SK; Weigel, NL | 1 |
Kelly, PA; Lee, CS; Ormandy, CJ; Sutherland, RL | 1 |
Chalbos, D; Galtier, F; Philips, A; Rochefort, H | 1 |
Furukawa, Y; Hayashi, K; Kida, N; Mori, K; Nagao, S; Nozawa, Y; Takahashi, H; Yoshimura, T | 1 |
Gullick, WJ; Johnson, GR; Prigent, SA; Stromberg, K | 1 |
Bassalyk, LS; Krasil'nikov, MA; Shatskaia, VA | 1 |
Cruz, MR; Finlay, TH; Kadner, SS; Levitz, M; Tamir, S; Yavelow, J | 1 |
Lewis, CE; McGee, JO; Pusztai, L | 1 |
Krishnan, V; Moore, M; Narasimhan, TR; Safe, S; Scott, AI; Wang, X; Williams, HJ | 1 |
Barinov, VV; Bassalyk, LS; Krasil'nikov, MA; Kuzmina, ZV; Letyagin, VP; Shatskaya, VA | 1 |
Moore, M; Narasimhan, TR; Safe, S; Steinberg, MA; Wang, X | 1 |
Blagosklonny, MV; Neckers, LM; Nguyen, P; Schulte, T; Trepel, J | 1 |
Figge, HL; Gierthy, JF; Pentecost, BT; Spink, BC; Spink, DC | 1 |
Chen, ZH; Gopalakrishna, R; Gundimeda, U | 1 |
Huber, M; Poulin, R | 1 |
Hughes, R; Schrey, MP; Timmermans, P | 1 |
Bar-Shalom, I; Beery, R; Geier, A; Haimsohn, M; Hemi, R; Karasik, A; Lunenfeld, B; Malik, Z | 1 |
Davidson, NE; Kennedy, MJ | 1 |
Buckwalter, E; Dabbs, D; Demers, L; Etindi, R; Kunselman, S; Manni, A; Mauger, D; Rossini, A | 1 |
Fodstad, O; Maelandsmo, GM; Ree, AH | 1 |
de Takats, PG; Kerr, DJ; Martin, A; Reynolds, JL; Wakelam, MJ | 1 |
Liu, XH; Rose, DP | 1 |
Agarwal, VR; Mendelson, CR; Simpson, ER; Zhao, Y | 1 |
Dickson, RB; Johnson, GR; Martinez-Lacaci, I; Salomon, DS | 1 |
Blagosklonny, MV; El-Deiry, WS; Prabhu, NS | 1 |
Anderson, WH; Kiss, Z | 1 |
Lunec, J; Nutt, JE | 1 |
Darne, C; Fabre, S; Jean, C; Veyssière, G | 1 |
Jouppila, A; Peltoketo, H; Piao, YS; Vihko, R | 1 |
Kostner, GM; Schmidt, H; Stranzl, A; Winkler, R | 1 |
Bandoh, S; Maruyama, K; Ohkura, N; Sasaki, K; Tsukada, T; Yamaguchi, K | 1 |
Beery, R; Geier, A; Haimsohn, M; Hemi, R; Karasik, A | 1 |
Chen, JJ; Gumin, GJ; Ijichi, A; Noel, F; Tofilon, PJ | 1 |
Culig, Z; Daxenbichler, G; Marth, C; Michel, S; Mörtl, MG; Widschwendter, A; Widschwendter, M; Zeimet, AG | 1 |
Burghardt, R; Porter, W; Safe, SH; Wang, WL | 1 |
Body, JJ; Lacroix, M | 1 |
Gillesby, BE; Porter, W; Safe, S; Stanostefano, M; Wu, ZF; Zacharewski, TR | 1 |
Abraham, JM; Balcer-Kubiczek, EK; Han, LH; Harrison, GH; Meltzer, SJ; Shi, ZM; Zhang, XF | 1 |
Agadir, A; Hill, DL; Shealy, YF; Zhang, X | 1 |
Galand, P; Horman, S; Leclercq, G; Legros, N; Mairesse, N; Mosselmans, R | 1 |
Ahmad, A; Anglard, P; Basset, P; Hart, IR; Marshall, JF | 1 |
Narvaez, CJ; Welsh, J | 1 |
Fueyo, A; López-Otín, C; Seiki, M; Ståhle-Bäckdahl, M; Uría, JA | 1 |
Magit, D; Pardee, AB; Sager, R; Zhang, M | 1 |
Brown, PH; Kim, HT; Munoz-Medellin, D; Reddy, P; Yang, L | 1 |
Alblas, J; Dufourny, B; Steenbergh, PH; Sussenbach, JS; van der Burg, B; van Schaik, FM; van Teeffelen, HA | 1 |
Holth, LT; Reeves, R; Thorlacius, AE | 1 |
DeLeon-Fernandez, M; Dutcher, JP; Etkind, P; Oleksowicz, L | 1 |
Huang, TS; Jee, SH; Kuo, ML; Shen, SC | 1 |
Alalami, O; Martin, JH | 1 |
Alblas, J; Slager-Davidov, R; Steenbergh, PH; Sussenbach, JS; van der Burg, B | 1 |
Bale, TL; Dorsa, DM | 2 |
Derocq, D; Garcia, M; Joubert, D; Platet, N; Prévostel, C; Rochefort, H | 1 |
Kiang, DT; Li, GY; Lin, HH; Tu, ZJ | 1 |
Arteaga, CL; Ohmori, T | 1 |
Aasen, AO; Bjørnland, K; Brünner, N; Fodstad, O; Johansen, HT; Pedersen, KB; Ree, AH | 1 |
Hunzicker-Dunn, M; Kawakatsu, H; Krett, NL; Maizels, ET; Murad, FM; Peters, CA; Rosen, ST; Shanmugam, M | 1 |
Linder, S; Ljungdahl, S; Shoshan, MC; Swedenborg, J; Zhou, JN | 1 |
Anderson, WH; Crilly, KS; Kiss, Z | 1 |
Boorne, AJ; Donnelly, N; Schrey, MP | 1 |
Alvarez-Dolado, M; González-Sancho, JM; Muñoz, A | 1 |
Devoe, G; Gear, R; Heffelfinger, SC; Miller, MA | 1 |
Fasco, MJ; Gierthy, JF; Spink, BC; Spink, DC | 1 |
Harris, AL; Jönsson, M; Smith, K | 1 |
Chiu, IM; Chotani, MA; Payson, RA | 1 |
Krishan, A; Kunikane, H; Ramachandran, C; You, W | 1 |
Horiguchi, J; Horii, Y; Iino, Y; Koibuchi, Y; Maemura, M; Morishita, Y; Ohwada, S; Takei, H; Takeyoshi, I; Yokoe, T | 1 |
Casida, JE; Rowlands, JC | 1 |
Colburn, NH; Fan, M; Li, JJ; Oberley, LW | 1 |
Chipman, JK; Dale, IL; Gant, TW; Gescher, A; Kerr, DJ; Schultze-Mosgau, MH | 1 |
Bhuiyan, M; Li, Y; Mohammad, RM; Sarkar, FH | 1 |
Belinson, J; Morton, RE; Shen, Z; Xu, Y | 1 |
Grover, PL; Gusterson, BA; Millar, BC; Phillips, DH; Stone, EM; Williams, JA | 1 |
Berstein, LM; Diano, S; Eliza, M; Gutierrez, L; Harada, N; Lysiak, J; Mor, G; Naftolin, F; Santen, RJ; Wang, J; Yue, W | 1 |
Dickson, RB; Johnson, MD; Lippman, ME; Torri, JA | 1 |
Barnes, D; Bastiaens, PI; Bornancin, F; Hanby, A; Hansra, G; Harris, W; Mellor, H; Ng, T; Parker, PJ; Prevostel, C; Schmidt, S; Squire, A | 1 |
Akiyama, SK; Dickson, RB; Johnson, MD; Maemura, M; Rosfjord, EC; Torri, JA; Woods, VL | 1 |
El-Deiry, WS; Mitchell, KO | 1 |
Agadir, A; Hashimoto, Y; Kagechika, H; Li, Y; Zhang, Xk | 1 |
Carey, I; Noti, JD; Ways, DK; Williams, CL | 1 |
French, DL; Hahn-Dantona, E; Nagase, H; Quigley, JP; Ramos-DeSimone, N; Sipley, J | 1 |
Anisowicz, A; Sager, R; Sotiropoulou, G | 1 |
Alalami, O; Martin, JH; van den Berg, HW | 1 |
Agadir, A; Bost, F; Chen, Gq; Li, Y; Mercola, D; Zhang, X | 1 |
Dumaz, N; Jardine, LJ; Meek, DW; Milne, DM | 1 |
Côté, S; Gingras, S; Simard, J | 1 |
Agmon-Levin, N; Altevogt, P; Gutwein, P; Krauss, K; Mechtersheimer, S; Oleszewski, M | 1 |
Kolluri, SK; Lin, F; Xiao, D; Zhang, X | 1 |
Adamson, ED; de Belle, I; Mercola, D | 1 |
Bates, SE; Bishop, PC; Blagosklonny, MV; Fojo, T; Robey, R | 1 |
Dufourny, B; Hamelers, IH; Steenbergh, PH; Sussenbach, JS | 1 |
Noti, JD | 1 |
Alpaugh, ML; Barsky, SH; Deato, M; Dishakjian, L; Lee, MC; Nguyen, M | 1 |
Bowler, WB; Gallagher, JA; Hipskind, RA; Wagstaff, SC | 1 |
Balmer, LA; Beveridge, DJ; Jazayeri, JA; Leedman, PJ; Thomson, AM; Walker, CE | 1 |
Bouchier-Hayes, D; Condron, C; Redmond, HP; Wang, JH; Wu, QD | 1 |
Hisatake , J; Koeffler, HP; O'Kelly, J; Tomoyasu, S; Uskokovic, MR | 1 |
Kurebayashi, J; Oka, T; Otsuki, T; Sakaguchi, H; Ueki, A; Uno, M; Yamada, O; Yata, K; Yawata, Y | 1 |
Gant, TW; Gescher, A; Gill, PK | 1 |
Biswas, DK; Cruz, A; Dai, SC; Graner, E; Pardee, AB; Weiser, B | 1 |
Hunzicker-Dunn, M; Krett, NL; Maizels, ET; Murad, FM; Rosen, ST; Shanmugam, M | 1 |
Kumar, R; Mandal, M; Mazumdar, A; Mishra, SK | 1 |
Bogart, DF; Li, P; Lupu, R; Mehmi, I; Tsai, MS | 1 |
Brueggemeier, RW; Petrel, TA; Richards, JA | 1 |
Badia, E; Duchesne, MJ; Freiss, G; Pons, M; Rabenoelina, F; Semlali, A | 1 |
Dabrowska, M; Dziecioł, J; Jarzabek, K; Laudański, P; Wołczyński, S | 1 |
Patel, KV; Schrey, MP | 1 |
Azzam, HS; Thompson, EW | 1 |
Keyomarsi, K; Lee, SW; Paul, D; Sager, R; Tomasetto, C | 1 |
Chubb, CH; Fujiki, H; Giometti, C; Huberman, E; Kiguchi, K | 1 |
Estabrook, A; Fisher, PB; Gutierrez, MC; Jiang, H; Leon, JA; Waxman, S | 1 |
Eskild, W; Hansson, V; Knutsen, HK; Landmark, BF; Ree, AH | 1 |
Hayes, DF; Kufe, D; Perey, L | 1 |
Coppock, DL; Nathanson, L; Tansey, JB | 1 |
Guerrin, M; Mazars, P; Prats, H; Valette, A | 1 |
Guerrin, M; Guilbaud, N; Valette, A | 1 |
Anderson, WB; Karaszkiewicz, JW; Lee, SA | 1 |
Cardinale, I; Sehgal, PB; Tamm, I | 1 |
Andersson, LC; Järvinen, M; Virtanen, I | 1 |
Cho, HS; Katzenellenbogen, BS; NG, PA | 1 |
Davidson, NE; Kennedy, MJ; May, WS; Prestigiacomo, LJ; Tyler, G | 1 |
Pfahl, M; Tzukerman, M; Zhang, XK | 1 |
Cardinale, I; Murphy, JS; Tamm, I | 1 |
Dick, K; Malik, N; McDonald, VL; Modrell, B; Plowman, GD; Shoyab, M | 1 |
Doucas, V; Spyrou, G; Yaniv, M | 1 |
Harris, AL; Lunec, J; Nutt, JE | 1 |
Kudlow, JE; Paterson, AJ; Raja, RH; Shin, TH | 1 |
de Groot, RP; de Laat, SW; Isbrücker, L; Kruijer, W; van der Burg, B | 1 |
Bacus, SS; Chin, D; Huberman, E; Kiguchi, K; King, CR | 1 |
Eikvar, L; Eskild, W; Hansson, V; Lahooti, H; Landmark, BF; Ree, AH; Walaas, SI | 1 |
Cook, DI; Wegman, EA; Young, JA | 1 |
Finlay, TH; Kadner, SS; Katz, J; Tamir, S | 1 |
Dupont, MA; Gas, N; Guilbaud, NF; Valette, A | 1 |
Bignon, E; Kishimoto, A; Nishizuka, Y; Ogita, K | 1 |
Bayard, F; Delassus, F; Faye, JC; Guilbaud, N; Toulas, C | 1 |
Aakvaag, A; Lahooti, H; Thorsen, T | 1 |
Darbon, JM; Guerrin, M; Guilbaud, N; Monsarrat, B; Valette, A | 1 |
Abe, M; Kufe, D | 2 |
Bayard, F; Darbon, JM; Issandou, M; Tournier, JF | 1 |
Koga, M; Musgrove, EA; Sutherland, RL | 1 |
Bayard, F; Darbon, JM; Faucher, C; Issandou, M | 1 |
Berry, M; Chambon, P; Imler, JL; Nunez, AM | 1 |
Bjorge, JD; Kudlow, JE; Paterson, AJ | 1 |
Findlay, DM; Michelangeli, VP; Robinson, PJ | 1 |
Cavailles, V; Garcia, M; Rochefort, H | 1 |
Koga, M; Lee, CS; Sutherland, RL | 1 |
Eppenberger, U; Fabbro, D; Küng, W; Matter, A; Meyer, T; Novak-Hofer, I | 1 |
Kremer, S; Margolis, B; Skorecki, K | 1 |
Costa, SD; Eppenberger, U; Fabbro, D; Küng, W; Roos, W | 1 |
Barrera, G; Dianzani, MU; Farina, A; Ferretti, C; Frati, L; Gulino, A; Screpanti, I; Vacca, A | 1 |
Borner, C; Costa, SD; Eppenberger, U; Fabbro, D; Regazzi, R | 1 |
Bayard, F; Dupont, MA; Gas, N; Jozan, S; Roubinet, F; Valette, A | 1 |
Bayard, F; Darbon, JM; Issandou, M | 2 |
Gelmann, EP; Lippman, ME; Wilding, G | 1 |
Darbon, JM; Issandou, M | 1 |
Borner, C; Eppenberger, U; Fabbro, D; Wyss, R | 1 |
Eppenberger, U; Fabbro, D; Regazzi, R | 1 |
Boyle, DM; van der Walt, LA | 1 |
Bradley, JG; McDonald, VL; Shoyab, M; Todaro, GJ | 1 |
Bayard, F; Darbon, JM; Valette, A | 1 |
Bjorge, JD; Kudlow, JE | 1 |
Blumberg, PM; Kochenburger, RJ; Little, JB; Lovett, DR; Nagasawa, H; Schmit, A; Weichselbaum, RR | 1 |
2 review(s) available for tetradecanoylphorbol acetate and Breast Cancer
Article | Year |
---|---|
Protein kinase C and breast cancer.
Topics: Breast Neoplasms; Drug Resistance, Multiple; ErbB Receptors; Female; Humans; Neoplasm Metastasis; Protein Kinase C; Receptors, Estrogen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells.
Topics: Aromatase; Breast Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Epidermal Growth Factor; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Isoenzymes; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2002 |
324 other study(ies) available for tetradecanoylphorbol acetate and Breast Cancer
Article | Year |
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Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
Topics: Amides; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Neoplastic Stem Cells; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
Inhibition of cell invasion and migration by targeting matrix metalloproteinase-9 expression via sirtuin 6 silencing in human breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; NF-kappa B; Sirtuins; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2022 |
Inhibition of TPA‑induced metastatic potential by morin hydrate in MCF‑7 human breast cancer cells via the Akt/GSK‑3β/c‑Fos signaling pathway.
Topics: Breast Neoplasms; Cell Movement; Cell Survival; Flavonoids; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3 beta; Humans; MCF-7 Cells; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fos; Signal Transduction; Tetradecanoylphorbol Acetate | 2020 |
Bruton's agammaglobulinemia tyrosine kinase (Btk) regulates TPA‑induced breast cancer cell invasion via PLCγ2/PKCβ/NF‑κB/AP‑1‑dependent matrix metalloproteinase‑9 activation.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Breast Neoplasms; Cell Movement; Female; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; NF-kappa B; Phospholipase C gamma; Piperidines; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2021 |
Wild-type p53 controls the level of fibronectin expression in breast cancer cells.
Topics: Breast Neoplasms; Butadienes; Drug Resistance, Neoplasm; Female; Fibronectins; Furans; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Nitriles; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2017 |
Novel dual-targeting anti-proliferative dihydrotriazine-chalcone derivatives display suppression of cancer cell invasion and inflammation by inhibiting the NF-κB signaling pathway.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chalcone; Cyclooxygenase 2; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Humans; Inflammation; Inflammation Mediators; Lipopolysaccharides; Matrix Metalloproteinase 9; Mice; Monocytes; Neoplasm Invasiveness; NF-kappa B; Nitric Oxide Synthase Type II; RAW 264.7 Cells; Signal Transduction; Tetradecanoylphorbol Acetate; Triazines | 2018 |
Conditioned medium from stimulated macrophages inhibits growth but induces an inflammatory phenotype in breast cancer cells.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Cell Cycle Proteins; Cell Proliferation; Cell Survival; Cellular Senescence; Culture Media, Conditioned; Cytokines; Female; Gene Expression Regulation, Neoplastic; Humans; Inflammation Mediators; Macrophage Activation; Macrophages; MCF-7 Cells; Paracrine Communication; Phenotype; Signal Transduction; Tetradecanoylphorbol Acetate; THP-1 Cells; Time Factors; Triple Negative Breast Neoplasms | 2018 |
Orientin inhibits invasion by suppressing MMP-9 and IL-8 expression via the PKCα/ ERK/AP-1/STAT3-mediated signaling pathways in TPA-treated MCF-7 breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Glucosides; Humans; Interleukin-8; Luteolin; Matrix Metalloproteinase 9; MCF-7 Cells; Mitogen-Activated Protein Kinase 6; Neoplasm Invasiveness; NF-kappa B; Protein Kinase C-alpha; Signal Transduction; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Tissue Array Analysis; Transcription Factor AP-1 | 2018 |
Induction of heme oxygenase-1 and inhibition of TPA-induced matrix metalloproteinase-9 expression by andrographolide in MCF-7 human breast cancer cells.
Topics: Bilirubin; Breast Neoplasms; Carbon Monoxide; Cell Line, Tumor; Cell Movement; Diterpenes; Enzyme Induction; Female; Heme Oxygenase-1; Humans; Iron; MAP Kinase Signaling System; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transcriptional Activation | 2013 |
Effects of two disiloxanes ALIS-409 and ALIS-421 on chemoprevention in model experiments.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; Breast Neoplasms; Carcinogens; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Female; Fibroblasts; Humans; Lung; Mice; Mice, Inbred ICR; Morpholines; Papilloma; Piperazines; Siloxanes; Skin Neoplasms; Stromal Cells; Tetradecanoylphorbol Acetate | 2013 |
Luteolin 8-C-β-fucopyranoside inhibits invasion and suppresses TPA-induced MMP-9 and IL-8 via ERK/AP-1 and ERK/NF-κB signaling in MCF-7 breast cancer cells.
Topics: Breast Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukin-8; Luteolin; MAP Kinase Signaling System; Matrix Metalloproteinase 9; MCF-7 Cells; NF-kappa B; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2013 |
Skp2 regulates subcellular localization of PPARγ by MEK signaling pathways in human breast cancer.
Topics: Breast Neoplasms; Butadienes; Cell Line, Tumor; Enzyme Inhibitors; Female; Flavonoids; Humans; MAP Kinase Kinase 1; MAP Kinase Signaling System; MCF-7 Cells; Nitriles; Phosphorylation; PPAR gamma; Protein Kinase Inhibitors; Receptors, Estrogen; RNA Interference; RNA, Small Interfering; S-Phase Kinase-Associated Proteins; Tetradecanoylphorbol Acetate | 2013 |
Differential 12-O-Tetradecanoylphorbol-13-acetate-induced activation of rat mammary carcinoma susceptibility Fbxo10 variant promoters via a PKC-AP1 pathway.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Environmental Exposure; F-Box Proteins; Female; Gene Expression Regulation, Neoplastic; Genetic Variation; Humans; Jurkat Cells; Mammary Neoplasms, Experimental; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase Inhibitors; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Ubiquitin-Protein Ligases | 2015 |
Starfish polysaccharides downregulate metastatic activity through the MAPK signaling pathway in MCF-7 human breast cancer cells.
Topics: Animals; Aromatase; Breast Neoplasms; Cell Movement; Cyclooxygenase 2; Down-Regulation; Female; Humans; I-kappa B Proteins; MAP Kinase Signaling System; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Metastasis; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Polysaccharides; Starfish; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinases; Transcription, Genetic | 2013 |
Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9.
Topics: Breast Neoplasms; Carcinogens; Cell Movement; Cell Survival; Female; Gene Expression Regulation, Enzymologic; Humans; Indoles; Matrix Metalloproteinase 9; MCF-7 Cells; Mitogen-Activated Protein Kinases; NF-kappa B; Protein Tyrosine Phosphatases; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2013 |
Disruption of endothelial adherens junction by invasive breast cancer cells is mediated by reactive oxygen species and is attenuated by AHCC.
Topics: Acetylcysteine; Adherens Junctions; Antigens, CD; Antineoplastic Agents, Phytogenic; Antioxidants; beta Catenin; Breast Neoplasms; Cadherins; Cell Movement; Endothelial Cells; Endothelium, Vascular; Female; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen Peroxide; Male; Ovarian Neoplasms; Plant Extracts; Prostatic Neoplasms; Reactive Oxygen Species; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 2013 |
Sanguinarine inhibits invasiveness and the MMP-9 and COX-2 expression in TPA-induced breast cancer cells by inducing HO-1 expression.
Topics: Anti-Infective Agents; Benzophenanthridines; Breast Neoplasms; Cell Movement; Cyclooxygenase 2; Female; Gene Expression Regulation, Neoplastic; Heme Oxygenase-1; Humans; Isoquinolines; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transcription Factor AP-1; Transcription Factor RelA | 2014 |
Berberine suppresses TPA-induced fibronectin expression through the inhibition of VEGF secretion in breast cancer cells.
Topics: Berberine; Breast Neoplasms; Cell Line, Tumor; Female; Fibronectins; Humans; MCF-7 Cells; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A | 2013 |
12-O-tetradecanoylphorbol-13-acetate promotes breast cancer cell motility by increasing S100A14 level in a Kruppel-like transcription factor 4 (KLF4)-dependent manner.
Topics: Animals; Base Sequence; Binding Sites; Breast Neoplasms; Calcium-Binding Proteins; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Mice; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors | 2014 |
Building bridges toward invasion: tumor promoter treatment induces a novel protein kinase C-dependent phenotype in MCF10A mammary cell acini.
Topics: Acinar Cells; Actins; Breast Neoplasms; Cadherins; Carcinogenesis; Cell Aggregation; Cell Death; Cell Line; Cell Polarity; Female; Humans; Laminin; Mammary Glands, Human; Mitosis; Neoplasm Invasiveness; Phenotype; Protein Kinase C; Tetradecanoylphorbol Acetate; Time Factors | 2014 |
Decursin prevents TPA-induced invasion through suppression of PKCα/p38/NF-κB-dependent MMP-9 expression in MCF-7 human breast carcinoma cells.
Topics: Benzopyrans; Breast Neoplasms; Butyrates; Carcinogens; Cell Proliferation; Cell Survival; Female; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; Signal Transduction; Tetradecanoylphorbol Acetate | 2014 |
Sulforaphane inhibits phorbol ester-stimulated IKK-NF-κB signaling and COX-2 expression in human mammary epithelial cells by targeting NF-κB activating kinase and ERK.
Topics: Anticarcinogenic Agents; Breast Neoplasms; Cell Line; Cyclooxygenase 2; Drug Screening Assays, Antitumor; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression; Humans; I-kappa B Kinase; Isothiocyanates; Mammary Glands, Human; MAP Kinase Signaling System; NF-kappa B; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Sulfoxides; Tetradecanoylphorbol Acetate | 2014 |
Shikonin blocks migration and invasion of human breast cancer cells through inhibition of matrix metalloproteinase-9 activation.
Topics: Breast Neoplasms; Cell Movement; Female; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; MCF-7 Cells; Naphthoquinones; Neoplasm Invasiveness; Signal Transduction; Tetradecanoylphorbol Acetate | 2014 |
Furanodiene, a natural small molecule suppresses metastatic breast cancer cell migration and invasion in vitro.
Topics: Antineoplastic Agents; Biological Products; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Furans; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 2-Ring; Humans; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Metastasis; Tetradecanoylphorbol Acetate | 2014 |
Metastatic potential in MDA-MB-231 human breast cancer cells is inhibited by proton beam irradiation via the Akt/nuclear factor-κB signaling pathway.
Topics: Breast Neoplasms; Cell Line, Tumor; Cyclooxygenase 2; Female; Gene Expression; Humans; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 9; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Protons; Radiation, Ionizing; Signal Transduction; Tetradecanoylphorbol Acetate | 2014 |
Saussurea lappa extract suppresses TPA-induced cell invasion via inhibition of NF-κB-dependent MMP-9 expression in MCF-7 breast cancer cells.
Topics: Breast Neoplasms; Cell Movement; Cell Survival; Down-Regulation; Female; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; NF-kappa B; Phosphorylation; Plant Extracts; Saussurea; Tetradecanoylphorbol Acetate; Transcriptional Activation | 2014 |
Delphinidin suppresses PMA-induced MMP-9 expression by blocking the NF-κB activation through MAPK signaling pathways in MCF-7 human breast carcinoma cells.
Topics: Anthocyanins; Breast Neoplasms; Cell Proliferation; Female; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; MCF-7 Cells; NF-kappa B; Tetradecanoylphorbol Acetate | 2014 |
Suppression of PMA-induced tumor cell invasion and migration by ginsenoside Rg1 via the inhibition of NF-κB-dependent MMP-9 expression.
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinogens; Cell Movement; Drug Antagonism; Female; Gene Expression Regulation, Neoplastic; Ginsenosides; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; NF-kappa B; Tetradecanoylphorbol Acetate | 2014 |
Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion.
Topics: Breast Neoplasms; Carcinogens; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Drug Interactions; Female; Fibrosarcoma; Humans; MAP Kinase Signaling System; Phosphorylation; Sirolimus; Tetradecanoylphorbol Acetate | 2014 |
Dibenzoylmethane, hydroxydibenzoylmethane and hydroxymethyldibenzoylmethane inhibit phorbol-12-myristate 13-acetate‑induced breast carcinoma cell invasion.
Topics: Acetophenones; Benzopyrans; Breast Neoplasms; Cell Movement; Chalcones; Chromones; Female; Humans; Ketones; Matrix Metalloproteinase 9; MCF-7 Cells; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Propane; Protein Kinase C-delta; Signal Transduction; Tetradecanoylphorbol Acetate | 2015 |
Antroquinonol from Antrodia Camphorata suppresses breast tumor migration/invasion through inhibiting ERK-AP-1- and AKT-NF-κB-dependent MMP-9 and epithelial-mesenchymal transition expressions.
Topics: Antrodia; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Survival; Down-Regulation; Epithelial-Mesenchymal Transition; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Mitogen-Activated Protein Kinase 3; NF-kappa B; Phosphorylation; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Ubiquinone | 2015 |
Glaucine inhibits breast cancer cell migration and invasion by inhibiting MMP-9 gene expression through the suppression of NF-κB activation.
Topics: Aporphines; Breast Neoplasms; Cell Movement; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; NF-kappa B; Promoter Regions, Genetic; Protein Binding; Proteolysis; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic | 2015 |
Aurora kinases are essential for PKC-induced invasion and matrix metalloproteinase-9 expression in MCF-7 breast cancer cells.
Topics: Aurora Kinase A; Aurora Kinase B; Breast Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Mitogen-Activated Protein Kinase Kinases; Neoplasm Invasiveness; NF-kappa B; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate | 2015 |
Fisetin regulates TPA-induced breast cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways.
Topics: Breast Neoplasms; Cell Membrane; DNA; Enzyme Activation; Flavonoids; Flavonols; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; MCF-7 Cells; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; NF-kappa B; Protein Kinase C-alpha; Protein Transport; Reactive Oxygen Species; Tetradecanoylphorbol Acetate | 2015 |
Inhibition of Breast Cancer Cell Proliferation and In Vitro Tumorigenesis by a New Red Apple Cultivar.
Topics: Anthocyanins; Antineoplastic Agents; Breast Neoplasms; Carcinogenesis; Cell Division; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Fruit and Vegetable Juices; G2 Phase; Humans; Malus; MCF-7 Cells; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Polyphenols; Tetradecanoylphorbol Acetate | 2015 |
Notch1 Activation or Loss Promotes HPV-Induced Oral Tumorigenesis.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Breast Neoplasms; Carcinogens; Carcinoma, Verrucous; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cocarcinogenesis; Disease Progression; DNA Transposable Elements; Female; Humans; Mice; Mice, Transgenic; Mouth Neoplasms; Mutagenesis, Insertional; Neoplasm Invasiveness; Oncogenes; Papilloma; Papillomaviridae; Receptor, Notch1; Skin Neoplasms; Specific Pathogen-Free Organisms; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Virus Infections; Uterine Cervical Neoplasms | 2015 |
Suppression of TPA-induced cancer cell invasion by Peucedanum japonicum Thunb. extract through the inhibition of PKCα/NF-κB-dependent MMP-9 expression in MCF-7 cells.
Topics: Antineoplastic Agents, Phytogenic; Apiaceae; Breast; Breast Neoplasms; Carcinogens; Female; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; NF-kappa B; Protein Kinase C-alpha; Signal Transduction; Tetradecanoylphorbol Acetate | 2016 |
Crosstalk between Wnt signaling and Phorbol ester-mediated PKC signaling in MCF-7 human breast cancer cells.
Topics: Breast Neoplasms; Cadherins; Cell Movement; Epithelial-Mesenchymal Transition; GATA3 Transcription Factor; Humans; MCF-7 Cells; Protein Kinase C; Protein Kinase C-alpha; Proto-Oncogene Proteins; Tetradecanoylphorbol Acetate; Time Factors; Up-Regulation; Wnt Proteins; Wnt Signaling Pathway; Wnt-5a Protein | 2016 |
Phorbol myristate acetate suppresses breast cancer cell growth via down-regulation of P-Rex1 expression.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Female; Guanine Nucleotide Exchange Factors; Humans; Indoles; Maleimides; MCF-7 Cells; Protein Isoforms; Protein Kinase C; Receptor, ErbB-2; RNA Interference; RNA, Small Interfering; Tetradecanoylphorbol Acetate | 2016 |
Docosahexaenoic acid inhibits 12-O-tetradecanoylphorbol-13- acetate-induced fascin-1-dependent breast cancer cell migration by suppressing the PKCδ- and Wnt-1/β-catenin-mediated pathways.
Topics: Breast Neoplasms; Carcinogens; Carrier Proteins; Cell Line, Tumor; Cell Movement; Docosahexaenoic Acids; Female; Humans; Microfilament Proteins; Protein Kinase C-delta; Tetradecanoylphorbol Acetate; Wnt Signaling Pathway | 2016 |
MicroRNA-720 suppresses M2 macrophage polarization by targeting GATA3.
Topics: Base Sequence; Breast Neoplasms; Cell Differentiation; Cell Line, Tumor; Female; GATA3 Transcription Factor; Gene Expression Regulation, Neoplastic; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interferon-gamma; Lipopolysaccharides; Macrophages; MicroRNAs; Primary Cell Culture; Signal Transduction; Tetradecanoylphorbol Acetate; THP-1 Cells | 2016 |
Leptin promotes migration and invasion of breast cancer cells by stimulating IL-8 production in M2 macrophages.
Topics: Animals; Antibodies, Blocking; Breast Neoplasms; Cell Differentiation; Cell Movement; Female; Humans; Interleukin-8; Leptin; Macrophages; MAP Kinase Signaling System; MCF-7 Cells; Mice; Mice, Nude; p38 Mitogen-Activated Protein Kinases; Phosphorylation; RAW 264.7 Cells; Receptors, Leptin; Tetradecanoylphorbol Acetate; Th1 Cells; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Down-Regulation of Protein Kinase C-ε by Prolonged Incubation with PMA Inhibits the Proliferation of Vascular Smooth Muscle Cells.
Topics: Animals; Breast Neoplasms; Cell Proliferation; Cell Survival; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Female; Gene Silencing; MAP Kinase Signaling System; Mice, Nude; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein Kinase C-epsilon; RNA, Small Interfering; Tetradecanoylphorbol Acetate | 2016 |
Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells.
Topics: Biphenyl Compounds; Breast Neoplasms; Carcinogens; Cell Movement; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Hydrazines; Hydroxyl Radical; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Picrates; Protein Kinase C-delta; Quercetin; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic | 2008 |
Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells.
Topics: Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Phosphorylation; Protein Kinase Inhibitors; Silybin; Silymarin; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A | 2009 |
Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid.
Topics: Blotting, Western; Breast Neoplasms; Carcinogens; Cell Line, Tumor; Ceramides; Enzyme-Linked Immunosorbent Assay; Female; Gene Silencing; Glucosylceramidase; Humans; Inositol; Interleukin-6; Mitogen-Activated Protein Kinase 13; Phosphorylation; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2009 |
Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation.
Topics: Blotting, Western; Breast Neoplasms; Carcinogens; Cell Line, Tumor; Ceramides; Chromatography, High Pressure Liquid; Female; Gene Silencing; Glucosylceramidase; Glucosylceramides; Humans; Lysosomes; Protein Kinase C; RNA, Small Interfering; Sphingomyelins; Sphingosine; Tandem Mass Spectrometry; Tetradecanoylphorbol Acetate | 2009 |
BMP-6 inhibits microRNA-21 expression in breast cancer through repressing deltaEF1 and AP-1.
Topics: Apoptosis Regulatory Proteins; Bone Morphogenetic Protein 6; Breast Neoplasms; Cadherins; Cell Line, Tumor; Down-Regulation; Homeodomain Proteins; Humans; MicroRNAs; Mutagenesis, Site-Directed; RNA-Binding Proteins; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factors; Transfection; Zinc Finger E-box-Binding Homeobox 1 | 2009 |
Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells.
Topics: Acetophenones; Animals; Antineoplastic Agents, Phytogenic; Benzopyrans; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Neoplasm Transplantation; NF-kappa B; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C-delta; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transplantation, Heterologous | 2009 |
Nanoliposomal short-chain ceramide inhibits agonist-dependent translocation of neurotensin receptor 1 to structured membrane microdomains in breast cancer cells.
Topics: Blotting, Western; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Ceramides; Enzyme Activation; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Immunoprecipitation; Liposomes; Membrane Microdomains; Mitogen-Activated Protein Kinases; Nanotechnology; Neurotensin; Protein Binding; Protein Transport; Receptors, Neurotensin; Tetradecanoylphorbol Acetate | 2009 |
Subcellular localization of cyclic AMP-responsive element binding protein-regulated transcription coactivator 2 provides a link between obesity and breast cancer in postmenopausal women.
Topics: Aromatase; Breast Neoplasms; Colforsin; DNA Primers; Estradiol; Estrogens; Female; Genes, Reporter; Homeostasis; Humans; Leptin; Mammaplasty; Obesity; Polymerase Chain Reaction; Postmenopause; Restriction Mapping; Stromal Cells; Tetradecanoylphorbol Acetate; Transcription Factors; Transfection | 2009 |
Silibinin prevents TPA-induced MMP-9 expression by down-regulation of COX-2 in human breast cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Breast Neoplasms; Butadienes; Celecoxib; Cell Line, Tumor; Cyclooxygenase 2; Down-Regulation; Humans; MAP Kinase Kinase Kinases; Matrix Metalloproteinase 1; Matrix Metalloproteinase 9; Nitriles; Phytotherapy; Protein Kinase Inhibitors; Pyrazoles; Seeds; Silybin; Silybum marianum; Silymarin; Sulfonamides; Tetradecanoylphorbol Acetate | 2009 |
Anti-inflammatory and anticarcinogenic effect of genistein alone or in combination with capsaicin in TPA-treated rat mammary glands or mammary cancer cell line.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Blotting, Western; Breast Neoplasms; Capsaicin; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Drug Synergism; Female; Genistein; Humans; Mammary Glands, Animal; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinases; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 2009 |
Identification of a Sam68 ribonucleoprotein complex regulated by epidermal growth factor.
Topics: Adaptor Proteins, Signal Transducing; Alternative Splicing; Blotting, Western; Breast Neoplasms; Cell Movement; Cell Nucleus; DNA-Binding Proteins; Epidermal Growth Factor; Female; Fluorescent Antibody Technique; HeLa Cells; Humans; Hyaluronan Receptors; Immunoprecipitation; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA-Binding Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2009 |
Bee venom suppresses PMA-mediated MMP-9 gene activation via JNK/p38 and NF-kappaB-dependent mechanisms.
Topics: Antineoplastic Agents; Apitherapy; Bee Venoms; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; DNA; Female; Humans; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 9; Melitten; Neoplasm Invasiveness; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Signal Transduction; Tetradecanoylphorbol Acetate; Transcriptional Activation | 2010 |
The licorice flavonoid isoliquiritigenin suppresses phorbol ester-induced cyclooxygenase-2 expression in the non-tumorigenic MCF-10A breast cell line.
Topics: Base Sequence; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Chalcones; Cyclooxygenase 2; Dinoprostone; DNA Primers; Electrophoretic Mobility Shift Assay; Female; Glycyrrhiza; Humans; Polymerase Chain Reaction; Tetradecanoylphorbol Acetate | 2010 |
Cordycepin inhibits TPA-induced matrix metalloproteinase-9 expression by suppressing the MAPK/AP-1 pathway in MCF-7 human breast cancer cells.
Topics: Analysis of Variance; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Deoxyadenosines; Female; Gene Expression; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; NF-kappa B; Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2010 |
Receptor-binding cancer antigen expressed on SiSo cells induces apoptosis via ectodomain shedding.
Topics: Antigens, Neoplasm; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Coculture Techniques; Female; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; MAP Kinase Signaling System; Neoplasms; Phosphorylation; Signal Transduction; Tetradecanoylphorbol Acetate; Uterine Neoplasms | 2010 |
Hyul-Tong-Ryung suppresses PMA-induced MMP-9 expression by inhibiting AP-1-mediated gene expression via ERK 1/2 signaling pathway in MCF-7 human breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; DNA; Drugs, Chinese Herbal; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression; Genes, Reporter; Humans; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; NF-kappa B; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Kinase Inhibitors; Response Elements; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factor RelA; Transfection | 2010 |
Piceatannol inhibits phorbol ester-induced NF-kappa B activation and COX-2 expression in cultured human mammary epithelial cells.
Topics: Anti-Inflammatory Agents; Antioxidants; Breast; Breast Neoplasms; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cyclooxygenase 2; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Epithelial Cells; Female; Humans; I-kappa B Kinase; NF-kappa B; Phosphorylation; Protein Transport; Stilbenes; Tetradecanoylphorbol Acetate | 2009 |
Matrix metalloproteinase-9 is required for tubular network formation and migration of resistant breast cancer cells MCF-7 through PKC and ERK1/2 signalling pathways.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Drug Resistance, Neoplasm; Female; Flavonoids; Humans; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate | 2010 |
Potential role of cyclooxygenase-2 on the regulation of the drug efflux transporter ABCG2 in breast cancer cell lines.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Celecoxib; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Flow Cytometry; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Mitoxantrone; Neoplasm Proteins; Pyrazoles; Sulfonamides; Tetradecanoylphorbol Acetate | 2011 |
The immunoglobulin-like cell adhesion molecule hepaCAM is cleaved in the human breast carcinoma MCF7 cells.
Topics: Breast Neoplasms; Calcium; Calcium Signaling; Carcinoma; Cell Adhesion Molecules; Cell Cycle Proteins; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Female; Humans; Immunoglobulins; Models, Biological; Molecular Weight; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Isoforms; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proteins; Tetradecanoylphorbol Acetate | 2010 |
12-O-Tetradecanoyl phorbol-13-acetate (TPA)-induced growth arrest is increased by silibinin by the down-regulation of cyclin B1 and cdc2 and the up-regulation of p21 expression in MDA-MB231 human breast cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; CDC2 Protein Kinase; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Croton Oil; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Phosphatidylinositol 3-Kinases; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-akt; Signal Transduction; Silybum marianum; Silymarin; Tetradecanoylphorbol Acetate | 2010 |
MYB suppresses differentiation and apoptosis of human breast cancer cells.
Topics: Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Butyrates; Cell Differentiation; Cell Line; Cell Line, Tumor; Drug Synergism; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Gene Expression; Green Fluorescent Proteins; Humans; Mice; Microscopy, Fluorescence; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myb; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tetradecanoylphorbol Acetate; Vitamin E; Vitamins | 2010 |
The dietary flavonoid apigenin blocks phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in breast cell lines.
Topics: Animals; Apigenin; Apoptosis; Blotting, Western; Breast Neoplasms; Caspase 3; Cell Division; Cell Line, Tumor; Cyclooxygenase 2; Dinoprostone; Electrophoretic Mobility Shift Assay; Extracellular Signal-Regulated MAP Kinases; Female; G2 Phase; Gene Expression Regulation, Enzymologic; Humans; Luciferases; Melanoma, Experimental; Mice; Protein Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcriptional Activation | 2010 |
6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation.
Topics: Antineoplastic Agents; Breast Neoplasms; Catechols; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Female; Humans; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 9; Matrix Metalloproteinases, Secreted; Neoplasm Invasiveness; NF-kappa B; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Zingiber officinale | 2010 |
Butein downregulates phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in cancerous and non-cancerous breast cells.
Topics: Breast; Breast Neoplasms; Cell Line, Tumor; Chalcones; Cyclooxygenase 2; Dinoprostone; Down-Regulation; Electrophoretic Mobility Shift Assay; Gene Expression Regulation, Neoplastic; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic; Transcriptional Activation | 2010 |
PMA-induced up-regulation of TBX3 is mediated by AP-1 and contributes to breast cancer cell migration.
Topics: Breast Neoplasms; Cell Movement; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Metastasis; Response Elements; RNA, Messenger; T-Box Domain Proteins; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Up-Regulation | 2011 |
Attenuation of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced gap junctional intercellular communication (GJIC) inhibition in MCF-10A cells by c9,t11-conjugated linoleic acid.
Topics: Breast Neoplasms; Cell Communication; Cell Line, Tumor; Connexin 43; Down-Regulation; Female; Gap Junctions; Humans; Linoleic Acids, Conjugated; Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; Tetradecanoylphorbol Acetate | 2010 |
Gossypol decreases tumor necrosis factor-α-induced intercellular adhesion molecule-1 expression via suppression of NF-κB activity.
Topics: Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Chromatin Immunoprecipitation; Electrophoretic Mobility Shift Assay; Flow Cytometry; Gossypol; Humans; Intercellular Adhesion Molecule-1; NF-kappa B; Okadaic Acid; Paclitaxel; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; U937 Cells | 2011 |
Dihydroavenanthramide D inhibits human breast cancer cell invasion through suppression of MMP-9 expression.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Survival; Humans; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; ortho-Aminobenzoates; Signal Transduction; Tetradecanoylphorbol Acetate | 2011 |
Tissue-specific regulation of aromatase promoter II by the orphan nuclear receptor LRH-1 in breast adipose stromal fibroblasts.
Topics: Adipose Tissue; Aromatase; Breast; Breast Neoplasms; Chromatin Immunoprecipitation; Colforsin; Dinoprostone; Female; Fibroblasts; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Humans; Organ Specificity; Postmenopause; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; RNA, Small Interfering; Stromal Cells; Tetradecanoylphorbol Acetate; Transfection | 2011 |
Differences in integrin expression and signaling within human breast cancer cells.
Topics: Adenocarcinoma; Antigens, Neoplasm; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Female; Focal Adhesions; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Integrin alphaVbeta3; Integrin beta3; Integrins; Neoplasm Proteins; Protein Kinases; Receptors, Urokinase Plasminogen Activator; Receptors, Vascular Endothelial Growth Factor; Receptors, Vitronectin; Signal Transduction; Stress Fibers; Tetradecanoylphorbol Acetate | 2011 |
Inflammation-induced loss of Pdcd4 is mediated by phosphorylation-dependent degradation.
Topics: Animals; Apoptosis Regulatory Proteins; Blotting, Western; Breast Neoplasms; Carcinogens; Cell Differentiation; Culture Media, Conditioned; Female; Genes, Tumor Suppressor; Humans; Inflammation; Interleukin-6; Interleukin-8; Macrophages; Mice; Mice, Inbred C57BL; Monocytes; Phosphatidylinositol 3-Kinases; Phosphorylation; Proteasome Endopeptidase Complex; Reverse Transcriptase Polymerase Chain Reaction; RNA-Binding Proteins; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Tumor Microenvironment; Tumor Necrosis Factor-alpha; U937 Cells | 2011 |
The effects of a plant proteinase inhibitor from Enterolobium contortisiliquum on human tumor cell lines.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fabaceae; Female; Fibroblasts; Humans; Leukemia; Leukocyte Elastase; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mesenchymal Stem Cells; Plant Proteins; Plasminogen; Protease Inhibitors; Tetradecanoylphorbol Acetate; Trypsin Inhibitors | 2011 |
Celastrol inhibits breast cancer cell invasion via suppression of NF-ĸB-mediated matrix metalloproteinase-9 expression.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Gene Expression Regulation, Enzymologic; Humans; I-kappa B Kinase; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Medicine, Chinese Traditional; Neoplasm Invasiveness; NF-kappa B; Pentacyclic Triterpenes; Promoter Regions, Genetic; Tetradecanoylphorbol Acetate; Triterpenes | 2011 |
Homeobox gene Dlx-2 is implicated in metabolic stress-induced necrosis.
Topics: Antigens, Surface; Apoptosis; Breast Neoplasms; Cell Aggregation; Cell Line, Tumor; Colonic Neoplasms; Female; Gene Expression Profiling; Gene Knockdown Techniques; Glucose; Humans; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membranes; Necrosis; Neoplasms; Oligonucleotide Array Sequence Analysis; Ovarian Neoplasms; Permeability; Reactive Oxygen Species; RNA Interference; Stress, Physiological; Tetradecanoylphorbol Acetate | 2011 |
Regulation of ADP-ribosylation factor 4 expression by small leucine zipper protein and involvement in breast cancer cell migration.
Topics: ADP-Ribosylation Factors; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cyclic AMP Response Element-Binding Protein; Female; Gene Expression Regulation, Neoplastic; Humans; Promoter Regions, Genetic; Response Elements; Tetradecanoylphorbol Acetate | 2012 |
TPA-induced p21 expression augments G2/M arrest through a p53-independent mechanism in human breast cancer cells.
Topics: Breast Neoplasms; Butadienes; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Inhibitors; Female; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; M Phase Cell Cycle Checkpoints; MAP Kinase Signaling System; Nitriles; Phosphorylation; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2012 |
Epidermal growth factor receptor (EGFR)-mediated positive feedback of protein-tyrosine phosphatase epsilon (PTPepsilon) on ERK1/2 and AKT protein pathways is required for survival of human breast cancer cells.
Topics: Breast Neoplasms; Carcinogens; Cell Line, Tumor; Cell Survival; Enzyme Activation; ErbB Receptors; Female; Fibroblast Growth Factors; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Proto-Oncogene Proteins c-akt; Receptor-Like Protein Tyrosine Phosphatases, Class 4; Tetradecanoylphorbol Acetate | 2012 |
The cadin-2-en-1β-ol-1β-D-glucuronopyranoside suppresses TPA-mediated matrix metalloproteinase-9 expression through the ERK signaling pathway in MCF-7 human breast adenocarcinoma cells.
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Catharanthus; Cell Line, Tumor; Dose-Response Relationship, Drug; Female; Glucosides; Humans; Matrix Metalloproteinase 9; Neoplasm Invasiveness; NF-kappa B; Phosphorylation; Sesquiterpenes; Signal Transduction; Tetradecanoylphorbol Acetate | 2012 |
Berberine suppresses the TPA-induced MMP-1 and MMP-9 expressions through the inhibition of PKC-α in breast cancer cells.
Topics: Adenocarcinoma; Berberine; Breast Neoplasms; Carcinogens; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Female; Humans; Matrix Metalloproteinase 1; Matrix Metalloproteinase 9; Phosphorylation; Protein Kinase C-alpha; RNA, Messenger; Tetradecanoylphorbol Acetate | 2012 |
N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell invasion through suppressing NF-KB activation and inhibiting matrix metalloproteinase-9 expression.
Topics: Breast Neoplasms; Cell Line; Cell Proliferation; Cell Survival; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Female; Fenretinide; Humans; Immunoblotting; Matrix Metalloproteinase 9; NF-kappa B; Reverse Transcriptase Polymerase Chain Reaction; Tetradecanoylphorbol Acetate | 2012 |
JNP3, a new compound, suppresses PMA-induced tumor cell invasion via NF-κB down regulation in MCF-7 breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Down-Regulation; Female; Gene Expression; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Kinase 4; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; NF-kappa B; Phosphorylation; Tetradecanoylphorbol Acetate; Triterpenes | 2012 |
Tubular network formation by adriamycin-resistant MCF-7 breast cancer cells is closely linked to MMP-9 and VEGFR-2/VEGFR-3 over-expressions.
Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Antibodies, Monoclonal, Humanized; Bevacizumab; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Doxorubicin; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factor Receptor-3 | 2012 |
Aqueous extract of Anisomeles indica and its purified compound exerts anti-metastatic activity through inhibition of NF-κB/AP-1-dependent MMP-9 activation in human breast cancer MCF-7 cells.
Topics: Base Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Movement; DNA Primers; Female; Humans; Lamiaceae; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; Plant Extracts; Reverse Transcriptase Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Water | 2012 |
Frondoside A has an anti-invasive effect by inhibiting TPA-induced MMP-9 activation via NF-κB and AP-1 signaling in human breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Female; Glycosides; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Triterpenes | 2012 |
Aromatic-turmerone attenuates invasion and expression of MMP-9 and COX-2 through inhibition of NF-κB activation in TPA-induced breast cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Survival; Chromatin Immunoprecipitation; Curcuma; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme Activation; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Ketones; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; RNA, Small Interfering; Sesquiterpenes; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1; Transfection | 2012 |
Curcumin suppresses the TPA-induced invasion through inhibition of PKCα-dependent MMP-expression in MCF-7 human breast cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Biological Transport; Breast Neoplasms; Cell Movement; Curcuma; Curcumin; Female; Humans; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Metastasis; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phytotherapy; Plant Extracts; Protein Kinase C-alpha; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2012 |
Phorbol ester TPA modulates chemoresistance in the drug sensitive breast cancer cell line MCF-7 by inducing expression of drug efflux transporter ABCG2.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Cell Line, Tumor; Cyclooxygenase 2; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate | 2012 |
Negative regulation of NF-κB by the ING4 tumor suppressor in breast cancer.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Disease Progression; Disease-Free Survival; Down-Regulation; Homeodomain Proteins; Humans; Neoplasm Invasiveness; Phosphorylation; Tetradecanoylphorbol Acetate; Transcription Factor RelA; Transcription, Genetic; Tumor Suppressor Proteins | 2012 |
Suppression of 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 breast adenocarcinoma cells invasion/migration by α-tomatine through activating PKCα/ERK/NF-κB-dependent MMP-2/MMP-9 expressions.
Topics: Actin Cytoskeleton; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Adhesion; Cell Movement; Cell Shape; Cell Survival; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; NF-kappa B; Phosphorylation; Protein Kinase C-alpha; Tetradecanoylphorbol Acetate; Tomatine; Transcriptional Activation | 2013 |
Surfactin suppresses TPA-induced breast cancer cell invasion through the inhibition of MMP-9 expression.
Topics: Antibiotics, Antineoplastic; Apoptosis; Blotting, Western; Breast Neoplasms; Carcinogens; Cell Movement; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Humans; Lipopeptides; Matrix Metalloproteinase 9; Neoplasm Invasiveness; NF-kappa B; Peptides, Cyclic; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Cells, Cultured; Wound Healing | 2013 |
Cis-guggulsterone inhibits the IKK/NF-κB pathway, whereas trans-guggulsterone inhibits MAPK/AP-1 in MCF‑7 breast cancer cells: guggulsterone regulates MMP‑9 expression in an isomer-specific manner.
Topics: Antineoplastic Agents, Phytogenic; Breast; Breast Neoplasms; Cell Survival; Commiphora; Female; Humans; I-kappa B Kinase; Isomerism; Matrix Metalloproteinase 9; MCF-7 Cells; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; NF-kappa B; Pregnenediones; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2013 |
Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells.
Topics: Adenocarcinoma; Androstadienes; Antineoplastic Agents; Breast Neoplasms; Carcinogens; Cell Movement; Cell Survival; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Drug Antagonism; Enzyme Activation; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Gene Silencing; Heme Oxygenase-1; Humans; Indoles; Maleimides; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; Tetradecanoylphorbol Acetate; Time Factors; Wortmannin | 2013 |
Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition of NF-κB-dependent MMP-9 expression.
Topics: Antineoplastic Agents; Benzofurans; Breast Neoplasms; Enzyme Induction; Female; Flavonoids; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; NF-kappa B; Protein Binding; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation | 2013 |
Silibinin inhibits TPA-induced cell migration and MMP-9 expression in thyroid and breast cancer cells.
Topics: Breast Neoplasms; Butadienes; Cell Movement; Female; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; Nitriles; Phosphorylation; Silybin; Silymarin; Tetradecanoylphorbol Acetate; Thyroid Neoplasms | 2013 |
Green tea inhibits vascular endothelial growth factor (VEGF) induction in human breast cancer cells.
Topics: Beverages; Blotting, Northern; Breast Neoplasms; Catechin; Cells, Cultured; Culture Media, Conditioned; Endothelial Growth Factors; Endothelium, Vascular; Female; Humans; Kinetics; Lymphokines; Plant Extracts; Protein Kinase C; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
Proteomic analysis of human lysosomes: application to monocytic and breast cancer cells.
Topics: Animals; Breast Neoplasms; Cell Differentiation; Cell Line; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Lysosomes; Mannosephosphates; Mass Spectrometry; Molecular Sequence Data; Monocytes; Proteins; Proteome; Sequence Analysis, Protein; Tetradecanoylphorbol Acetate | 2002 |
Constitutive and inducible expression of the epithelial antigen MUC1 (CD227) in human T cells.
Topics: Antibodies, Monoclonal; Antigens; Breast Neoplasms; Carcinoma, Lobular; CD3 Complex; Cell Division; Cell Membrane; Cells, Cultured; Dactinomycin; Epithelial Cells; Glycosylation; Golgi Apparatus; Humans; Leukocytes, Mononuclear; Molecular Weight; Mucin-1; Phytohemagglutinins; Protein Transport; RNA, Messenger; Solubility; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription, Genetic | 2002 |
Lymphotoxin and lipopolysaccharide induce NF-kappaB-p52 generation by a co-translational mechanism.
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; B-Lymphocytes; Breast Neoplasms; Dendritic Cells; DNA; Enzyme Activation; Female; HeLa Cells; Humans; I-kappa B Proteins; Interleukin-1; Lipopolysaccharides; Lymphotoxin beta Receptor; Lymphotoxin-alpha; Lymphotoxin-beta; Membrane Proteins; NF-kappa B; NF-kappa B p52 Subunit; NF-KappaB Inhibitor alpha; Protein Binding; Protein Precursors; Protein Processing, Post-Translational; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Ribosomes; Sequence Deletion; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription Factors; Tumor Cells, Cultured; Tumor Necrosis Factor Ligand Superfamily Member 14; Tumor Necrosis Factor-alpha; Ubiquitin | 2003 |
Activation of the MAP kinase pathway induces chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) expression in human breast cancer cell lines.
Topics: Blotting, Western; Breast Neoplasms; Butadienes; COUP Transcription Factor I; COUP Transcription Factor II; COUP Transcription Factors; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Female; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Oncostatin M; Peptides; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Transcription Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured | 2003 |
Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter.
Topics: Base Sequence; Breast Neoplasms; Dexamethasone; Endothelial Growth Factors; Estradiol; Haplotypes; Humans; Intercellular Signaling Peptides and Proteins; Lymphokines; Molecular Sequence Data; Polymorphism, Genetic; Promoter Regions, Genetic; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Ets2 and protein kinase C epsilon are important regulators of parathyroid hormone-related protein expression in MCF-7 breast cancer cells.
Topics: Base Sequence; Binding Sites; Breast Neoplasms; Cell Line, Transformed; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Parathyroid Hormone-Related Protein; Peptide Hormones; Promoter Regions, Genetic; Protein Binding; Protein Kinase C; Protein Kinase C-epsilon; Proto-Oncogene Protein c-ets-2; Proto-Oncogene Proteins; Repressor Proteins; Sp1 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription Factors; Transfection; Tumor Cells, Cultured | 2003 |
Protein kinase Calpha negatively regulates cell spreading and motility in MDA-MB-231 human breast cancer cells downstream of epidermal growth factor receptor.
Topics: Breast Neoplasms; Cell Movement; Cell Size; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Protein Kinase C; Protein Kinase C-alpha; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2003 |
An activator protein 1-like motif mediates 17beta-estradiol repression of gonadotropin-releasing hormone receptor promoter via an estrogen receptor alpha-dependent mechanism in ovarian and breast cancer cells.
Topics: Base Sequence; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Colforsin; DNA, Neoplasm; Estradiol; Estrogen Receptor alpha; Female; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Ovarian Neoplasms; Promoter Regions, Genetic; Receptors, Estrogen; Receptors, LHRH; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic | 2003 |
Cathepsin L gene expression and promoter activation in rodent granulosa cells.
Topics: Animals; Base Sequence; Binding Sites; Breast Neoplasms; Cathepsin L; Cathepsins; Cell Line; Chorionic Gonadotropin; Colforsin; CREB-Binding Protein; Cysteine Endopeptidases; DNA; DNA-Binding Proteins; Drosophila; Female; Gene Deletion; Gene Expression Regulation; Gonadotropins, Equine; Granulosa Cells; Humans; In Situ Hybridization; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutagenesis, Site-Directed; Nuclear Proteins; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Sp1 Transcription Factor; Sp3 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription Factors; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 2004 |
Functional imaging of proteolysis: stromal and inflammatory cells increase tumor proteolysis.
Topics: Breast Neoplasms; Carcinoma; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Survival; Coculture Techniques; Collagen; Collagen Type IV; Colonic Neoplasms; Drug Combinations; Endopeptidases; Humans; Hydroxamic Acids; Image Processing, Computer-Assisted; Immunohistochemistry; Laminin; Macrophages; Monocytes; Neoplasms; Proteoglycans; Spheroids, Cellular; Stromal Cells; Tetradecanoylphorbol Acetate; U937 Cells | 2003 |
Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor.
Topics: Amino Acid Sequence; Animals; Breast Neoplasms; Cell Adhesion Molecules; Dermatologic Surgical Procedures; GPI-Linked Proteins; Humans; Hyperplasia; Immunohistochemistry; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Peptide Fragments; Peptide Mapping; Placenta; Protein Interaction Mapping; Protein Processing, Post-Translational; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Skin; Tetradecanoylphorbol Acetate; Wound Healing | 2004 |
Immediate early gene X-1 (IEX-1), a hydroxytamoxifen regulated gene with increased stimulation in MCF-7 derived resistant breast cancer cells.
Topics: Apoptosis Regulatory Proteins; Base Sequence; Blotting, Northern; Breast Neoplasms; Cloning, Molecular; DNA Primers; Gene Expression Regulation, Neoplastic; Genes, Immediate-Early; Humans; Immediate-Early Proteins; Membrane Proteins; Neoplasm Proteins; Promoter Regions, Genetic; RNA, Messenger; Tamoxifen; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Suppressor Protein p53 | 2004 |
Mitogen-activated protein kinase phosphatase-3 is a tumor promoter target in initiated cells that express oncogenic Ras.
Topics: Acrylamides; Animals; Breast Neoplasms; Carcinogens; Cell Line; Cnidarian Venoms; Dual Specificity Phosphatase 6; Enzyme Activation; Gene Expression; Genes, ras; Humans; Immunoblotting; Keratinocytes; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Mice; Mitogen-Activated Protein Kinases; Okadaic Acid; Protein Tyrosine Phosphatases; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 2004 |
Exogenous prostaglandin E2 inhibits TPA induced matrix metalloproteinase-9 production in MCF-7 cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Collagen; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Drug Combinations; Enzyme Activation; Enzyme Induction; Humans; Laminin; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Metastasis; Proteoglycans; Receptors, Prostaglandin; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Tetradecanoylphorbol Acetate | 2004 |
Gene regulation by phorbol 12-myristate 13-acetate in MCF-7 and MDA-MB-231, two breast cancer cell lines exhibiting highly different phenotypes.
Topics: Biomarkers, Tumor; Breast Neoplasms; Carcinogens; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Invasiveness; Oligonucleotide Array Sequence Analysis; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2004 |
Glycoprotein isolated from Solanum nigrum L. inhibits the DNA-binding activities of NF-kappaB and AP-1, and increases the production of nitric oxide in TPA-stimulated MCF-7 cells.
Topics: Breast Neoplasms; Carcinogens; DNA Adducts; Female; Glycoproteins; Humans; NF-kappa B; Nitric Oxide; Plant Extracts; Pyridines; Solanum nigrum; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic; Tumor Cells, Cultured | 2004 |
PKCdelta and MAPK mediate G(1) arrest induced by PMA in SKBR-3 breast cancer cells.
Topics: Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Retinoblastoma; Tetradecanoylphorbol Acetate | 2005 |
IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner.
Topics: Amino Acid Sequence; Animals; Breast Neoplasms; Cell Line, Tumor; Epithelial Cells; Female; Humans; Indoles; Isoenzymes; Maleimides; Molecular Sequence Data; Neurites; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; ras GTPase-Activating Proteins; Rats; Recombinant Fusion Proteins; Serine; Tetradecanoylphorbol Acetate | 2005 |
Mitogen regulated induction of FRA-1 proto-oncogene is controlled by the transcription factors binding to both serum and TPA response elements.
Topics: Activating Transcription Factors; Blood Proteins; Breast Neoplasms; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mitogens; Promoter Regions, Genetic; Proto-Oncogene Mas; Proto-Oncogene Proteins c-fos; Serum Response Element; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 2005 |
Impact of PKCdelta on estrogen receptor localization and activity in breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; Estradiol; Estrogen Receptor alpha; Female; Genes, Reporter; Glycogen Synthase Kinase 3; Humans; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Receptors, Estrogen; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection | 2005 |
Flow cytometric analysis of circulating dendritic cell subsets and intracellular cytokine production in advanced breast cancer patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; CD11c Antigen; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Lineage; Cytokines; Dendritic Cells; Female; Flow Cytometry; HLA-DR Antigens; Humans; Interferon-gamma; Interleukin-3 Receptor alpha Subunit; Interleukin-4; Intracellular Space; Middle Aged; Receptors, Interleukin-3; Tetradecanoylphorbol Acetate; Time Factors; Treatment Outcome | 2005 |
Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells.
Topics: Anticarcinogenic Agents; Brassica; Breast Neoplasms; Carcinogens; Cell Line, Tumor; Cell Survival; Collagen; Drug Combinations; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Female; Formazans; Humans; Isothiocyanates; L-Lactate Dehydrogenase; Laminin; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Nasturtium; Plant Extracts; Proteoglycans; Sulfoxides; Tetradecanoylphorbol Acetate; Tetrazolium Salts; Thiocyanates | 2005 |
Conjugated linoleic acid attenuates cyclooxygenase-2 transcriptional activity via an anti-AP-1 mechanism in MCF-7 breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cyclic AMP; Cyclooxygenase 2; Humans; Linoleic Acids, Conjugated; Nuclear Proteins; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-jun; Response Elements; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic | 2006 |
The mitogen-activated protein kinase pathway can inhibit TRAIL-induced apoptosis by prohibiting association of truncated Bid with mitochondria.
Topics: Apoptosis; BH3 Interacting Domain Death Agonist Protein; Breast Neoplasms; Caspases; Enzyme Activation; Humans; MAP Kinase Signaling System; Mitochondria; Mitochondrial Membranes; Mitogen-Activated Protein Kinases; Permeability; Protein Binding; Protein Biosynthesis; Protein Kinase C; Protein Transport; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha | 2006 |
NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2.
Topics: Breast Neoplasms; Cell Line, Tumor; Collagen; Cyclooxygenase 2; Cyclosporine; Dinoprostone; Drug Combinations; Humans; Ionomycin; Ionophores; Laminin; Neoplasm Invasiveness; Neoplasm Metastasis; NFATC Transcription Factors; Proteoglycans; RNA, Small Interfering; Tetradecanoylphorbol Acetate | 2006 |
Activation of protein kinase C delta induces growth arrest in NPA thyroid cancer cells through extracellular signal-regulated kinase mitogen-activated protein kinase.
Topics: Adenoviridae; Breast Neoplasms; Carcinoma; Carcinoma, Papillary; Cell Cycle; Cell Line, Tumor; Cyclin E; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; G1 Phase; Humans; Protein Kinase C-delta; Proto-Oncogene Proteins B-raf; Retinoblastoma Protein; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Transfection | 2006 |
Chromatin modification of the trefoil factor 1 gene in human breast cancer cells by the Ras/mitogen-activated protein kinase pathway.
Topics: Binding Sites; Breast Neoplasms; Cell Line, Tumor; Chromatin; Estradiol; Gene Expression Regulation, Neoplastic; Histones; Humans; MAP Kinase Signaling System; Phosphorylation; Proto-Oncogene Proteins c-jun; ras Proteins; Ribosomal Protein S6 Kinases, 90-kDa; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic; Transcriptional Activation; Trefoil Factor-1; Tumor Suppressor Proteins | 2006 |
Reduction of invasion in human fibrosarcoma cells by ribosomal protein S3 in conjunction with Nm23-H1 and ERK.
Topics: Breast Neoplasms; Cell Line, Tumor; Fibrosarcoma; Humans; In Vitro Techniques; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Mutagenesis, Site-Directed; Neoplasm Invasiveness; NM23 Nucleoside Diphosphate Kinases; Nucleoside-Diphosphate Kinase; Recombinant Fusion Proteins; Ribosomal Proteins; Sequence Deletion; Tetradecanoylphorbol Acetate; Transfection; Two-Hybrid System Techniques | 2006 |
Soya isoflavones suppress phorbol 12-myristate 13-acetate-induced COX-2 expression in MCF-7 cells.
Topics: Anticarcinogenic Agents; Breast Neoplasms; Carcinogens; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Equol; Female; Genistein; Glycine max; Humans; Isoflavones; Membrane Proteins; Phytoestrogens; Plant Extracts; Promoter Regions, Genetic; Tetradecanoylphorbol Acetate | 2006 |
Real-time measurement of PMA-induced cellular alterations by microelectrode array-based impedance spectroscopy.
Topics: Alloys; Breast Neoplasms; Cell Line, Tumor; Electric Impedance; Epithelium; Feasibility Studies; Female; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Immunohistochemistry; Microelectrodes; Microscopy, Fluorescence; Nanotechnology; Nickel; Oligonucleotide Array Sequence Analysis; Spectrum Analysis; Tetradecanoylphorbol Acetate; Titanium | 2006 |
Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Combinations; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Silybin; Silymarin; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation | 2007 |
Immunotherapy of metastatic breast cancer patients with vitamin D-binding protein-derived macrophage activating factor (GcMAF).
Topics: Adult; Aged; alpha-N-Acetylgalactosaminidase; Breast Neoplasms; Female; Glycosylation; Humans; Immunotherapy; Macrophage Activation; Macrophage-Activating Factors; Macrophages; Middle Aged; Neoplasm Metastasis; Prognosis; Tetradecanoylphorbol Acetate; Vitamin D-Binding Protein | 2008 |
Antiproliferative and survival properties of PMA in MCF-7 breast cancer cell.
Topics: Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Fluorescent Antibody Technique; Gene Expression; Humans; Immunohistochemistry; p21-Activated Kinases; Phorbol Esters; Proliferating Cell Nuclear Antigen; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2008 |
Heme oxygenase-1 inhibits breast cancer invasion via suppressing the expression of matrix metalloproteinase-9.
Topics: Breast Neoplasms; Carbon Monoxide; Cell Line, Tumor; Cell Movement; Down-Regulation; Female; Heme Oxygenase-1; Humans; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Protein Kinase C; Reactive Oxygen Species; Signal Transduction; Tetradecanoylphorbol Acetate | 2008 |
An inhibitory effect of tumour promoters on human epithelial cell growth can be dissociated from an effect on junctional communication.
Topics: Breast Neoplasms; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Communication; Cell Division; Cell Line; Cell Transformation, Viral; Epidermal Cells; Epidermis; Humans; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Tetradecanoylphorbol Acetate | 1983 |
In vitro colon assay of peripheral blood mononuclear cells - a comparison of breast cancer patients and normal individuals.
Topics: Breast Neoplasms; Clone Cells; Female; Humans; Immunologic Techniques; Lymphocytes; Phytohemagglutinins; Tetradecanoylphorbol Acetate | 1982 |
Activation of multiple protein kinases by interleukin-1.
Topics: Animals; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Female; Glycogen Synthase Kinase 3; Humans; Interleukin-1; Interleukin-4; Mice; Protein Kinases; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured | 1995 |
Circumvention of P-glycoprotein-mediated multiple drug resistance by phosphorylation modulators is independent of protein kinases.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line; Dactinomycin; Doxorubicin; Drug Resistance, Multiple; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Kinetics; Phorbol Esters; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vinblastine | 1995 |
Modulation of protectin (CD59 antigen) cell surface expression on human neoplastic cell lines.
Topics: Antigens, CD; Breast Neoplasms; Calcitriol; Carcinoma; CD59 Antigens; Cell Membrane; Cytokines; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Female; Flow Cytometry; Fluorescent Antibody Technique; Glioma; Humans; Leukemia, Myeloid; Leukemia, Promyelocytic, Acute; Membrane Glycoproteins; Ovarian Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured; Up-Regulation | 1993 |
Cell-adhesion-disrupting action of interleukin 6 in human ductal breast carcinoma cells.
Topics: Breast Neoplasms; Cell Adhesion; Cell Division; Female; Fibroblast Growth Factor 1; Humans; Interleukin-6; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Effects of 12-O-tetradecanoylphorbol-13-acetate on estrogen receptor activity in MCF-7 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Base Sequence; Breast Neoplasms; Dose-Response Relationship, Drug; Estradiol; Female; Humans; Isoquinolines; Molecular Sequence Data; Piperazines; Protein Kinase C; Receptors, Estrogen; Receptors, Glucocorticoid; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd-45 in initiating death.
Topics: Apoptosis; Breast Neoplasms; Bryostatins; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dose-Response Relationship, Drug; Female; GADD45 Proteins; Genes, p53; Humans; Intracellular Signaling Peptides and Proteins; Isoenzymes; Lactones; Macrolides; Phosphorylation; Protein Kinase C; Proteins; Retinoblastoma Protein; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
The presence of a trifluoromethyl rather than a methyl substituent in the bay-region greatly decreases the DNA-binding and tumour-initiating activity of the cyclopenta[alpha]phenanthren-17-ones.
Topics: Animals; Breast Neoplasms; Carcinogens; Cell Line; DNA; DNA Adducts; Epidermis; Female; Gonanes; Humans; Methylation; Mice; Mice, Inbred SENCAR; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1995 |
Estrogen and phorbol esters regulate amphiregulin expression by two separate mechanisms in human breast cancer cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amphiregulin; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Bryostatins; Culture Media, Conditioned; Cycloheximide; Dose-Response Relationship, Drug; EGF Family of Proteins; Estradiol; Estrogen Antagonists; Estrogens; Gene Expression Regulation, Neoplastic; Glycoproteins; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Isoquinolines; Lactones; Macrolides; Piperazines; Polyunsaturated Alkamides; Protein Kinase C; Receptors, Estrogen; RNA, Messenger; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Very low density lipoprotein receptor binds and mediates endocytosis of urokinase-type plasminogen activator-type-1 plasminogen activator inhibitor complex.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Breast Neoplasms; Cattle; Cell Line; Cell Membrane; CHO Cells; Cricetinae; Endocytosis; Genetic Variation; Humans; Kinetics; Lipoproteins, VLDL; Mammary Glands, Animal; Molecular Sequence Data; Molecular Weight; Peptides; Plasminogen Activator Inhibitor 1; Receptors, LDL; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1995 |
Modulation of cell signaling pathways can enhance or impair glucocorticoid-induced gene expression without altering the state of receptor phosphorylation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Breast Neoplasms; Chloramphenicol O-Acetyltransferase; Colforsin; Dexamethasone; Ethers, Cyclic; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Genetic Vectors; Humans; Luciferases; Mammary Tumor Virus, Mouse; Okadaic Acid; Phosphopeptides; Phosphorylation; Promoter Regions, Genetic; Protein Tyrosine Phosphatases; Receptors, Glucocorticoid; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1993 |
Quantitative variation of proto-oncogene and cytokine gene expression in isolated breast fibroblasts.
Topics: Breast; Breast Neoplasms; Cell Division; Cytokines; Female; Fibroblasts; Gene Expression; Growth Substances; Humans; Interleukins; Protein Kinases; Proto-Oncogene Mas; Proto-Oncogenes; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 1995 |
Multiple pathways are involved in protection of MCF-7 cells against death due to protein synthesis inhibition.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aurintricarboxylic Acid; Breast Neoplasms; Cell Survival; Cycloheximide; DNA Damage; Genistein; Humans; Insulin-Like Growth Factor I; Isoflavones; Microscopy, Electron; Protein Synthesis Inhibitors; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Differential induction of apoptosis in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A.
Topics: Apoptosis; Breast Neoplasms; Electrophoresis; Ethers, Cyclic; Humans; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Prolonged treatment of breast cancer cells with antiestrogens increases the activating protein-1-mediated response: involvement of the estrogen receptor.
Topics: Base Sequence; Breast Neoplasms; Estrogen Antagonists; Luciferases; Molecular Sequence Data; Oligonucleotides; Osmolar Concentration; Receptors, Estrogen; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor AP-1; Tumor Cells, Cultured | 1995 |
Epidermal growth factor, phorbol esters, and aurintricarboxylic acid are survival factors for MDA-231 cells exposed to adriamycin.
Topics: Adenosine Triphosphate; Apoptosis; Aurintricarboxylic Acid; Breast Neoplasms; Cell Survival; Cycloheximide; DNA, Neoplasm; Doxorubicin; Epidermal Growth Factor; Humans; Insulin-Like Growth Factor I; L-Lactate Dehydrogenase; Microscopy, Electron; Protein Biosynthesis; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
erbB-2 expression in estrogen-receptor-positive breast-tumor cells is regulated by growth-modulatory reagents.
Topics: Base Sequence; Breast Neoplasms; Bucladesine; Cell Count; Epidermal Growth Factor; ErbB Receptors; Estradiol; Gene Expression; Growth Substances; Humans; Insulin; Molecular Sequence Data; Progesterone; Prolactin; Promoter Regions, Genetic; Proto-Oncogene Proteins; Receptor, ErbB-2; Receptors, Estrogen; RNA, Messenger; Tetradecanoylphorbol Acetate; Transfection; Tretinoin; Tumor Cells, Cultured | 1994 |
Proliferative responses of epithelial cells to 8-bromo-cyclic AMP and to a phorbol ester change during breast pathogenesis.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Biopsy; Breast; Breast Neoplasms; Cell Division; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Cholera Toxin; Epithelium; Humans; Reference Values; Tetradecanoylphorbol Acetate; Time Factors | 1994 |
Phorbol ester selectively stimulates the phospholipase D-mediated hydrolysis of phosphatidylethanolamine in multidrug-resistant MCF-7 human breast carcinoma cells.
Topics: Breast Neoplasms; Drug Resistance, Multiple; Glycerophospholipids; Glycerylphosphorylcholine; Humans; Hydrogen Peroxide; Hydrolysis; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipase D; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Regulation of the expression of alkaline phosphatase in a human breast-cancer cell line.
Topics: Alkaline Phosphatase; Blotting, Northern; Breast Neoplasms; Cell Line; Dexamethasone; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Placenta; Pregnancy; Protein Synthesis Inhibitors; RNA, Messenger; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1994 |
Differential regulation of matrix metalloproteinase-2 activation in human breast cancer cell lines.
Topics: Breast Neoplasms; Cell Line; Concanavalin A; Enzyme Activation; Gelatinases; Humans; Matrix Metalloproteinase 2; Metalloendopeptidases; Neoplasm Invasiveness; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vimentin | 1994 |
Increased phospholipase D activity in multidrug resistant breast cancer cells.
Topics: Breast Neoplasms; Cell Line; Diglycerides; Doxorubicin; Drug Resistance; Fatty Acids, Nonesterified; Female; Humans; Kinetics; Myristic Acid; Myristic Acids; Phosphatidic Acids; Phospholipase D; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1994 |
Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Northern; Blotting, Western; Breast Neoplasms; Calcium; Chromatography; Doxorubicin; Drug Resistance; Durapatite; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydroxyapatites; Intracellular Signaling Peptides and Proteins; Isoenzymes; Membrane Glycoproteins; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Phenotype; Phosphorylation; Poly A; Protein Kinase C; Proteins; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vinblastine; Vincristine | 1993 |
The role of protein kinase C isoenzymes in the growth inhibition caused by bryostatin 1 in human A549 lung and MCF-7 breast carcinoma cells.
Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Bryostatins; Cell Division; Chromatography; Durapatite; Enzyme Activation; Humans; Isoenzymes; Lactones; Lung Neoplasms; Macrolides; Protein Kinase C; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Synergistic effect of tamoxifen and phorbol ester TPA on retrovirus synthesis in a human mammary carcinoma cell line.
Topics: Breast Neoplasms; Drug Synergism; Humans; Receptors, Estrogen; Retroviridae; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
A common response element mediates differential effects of phorbol esters and forskolin on type-1 plasminogen activator inhibitor gene expression in human breast carcinoma cells.
Topics: Base Sequence; Binding Sites; Breast Neoplasms; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Molecular Sequence Data; Plasminogen Activator Inhibitor 1; Promoter Regions, Genetic; Protein Binding; Protein Kinase C; Proto-Oncogene Proteins c-jun; Signal Transduction; Sp1 Transcription Factor; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Corticotropin-releasing hormone, proopiomelanocortin, and glucocorticoid receptor gene expression in adrenocorticotropin-producing tumors in vitro.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenoma; Adrenocorticotropic Hormone; Adult; Aged; Arginine Vasopressin; Breast Neoplasms; Corticotropin-Releasing Hormone; Cushing Syndrome; Dexamethasone; Esophageal Neoplasms; Female; Gene Expression; Humans; Hydrocortisone; Lung Neoplasms; Male; Metyrapone; Middle Aged; Pituitary Neoplasms; Pro-Opiomelanocortin; Receptors, Glucocorticoid; RNA, Messenger; Tetradecanoylphorbol Acetate | 1993 |
Modulators of cellular protein phosphorylation alter the trans-activation function of human progesterone receptor and the biological activity of progesterone antagonists.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetyl Coenzyme A; Breast Neoplasms; Cell Line; DNA-Binding Proteins; Drug Synergism; Ethers, Cyclic; Female; Humans; Kinetics; Mifepristone; Okadaic Acid; Phosphates; Phosphoprotein Phosphatases; Phosphorylation; Receptors, Progesterone; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1993 |
Regulation of prolactin receptor expression by the tumour promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate in human breast cancer cells.
Topics: Breast Neoplasms; Carcinogens; Cycloheximide; Diglycerides; Diterpenes; Female; Gene Expression Regulation, Neoplastic; Half-Life; Humans; Protein Kinase C; Receptors, Prolactin; RNA, Messenger; RNA, Neoplasm; Terpenes; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Synthetic antiestrogens modulate induction of pS2 and cathepsin-D messenger ribonucleic acid by growth factors and adenosine 3',5'-monophosphate in MCF7 cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Breast Neoplasms; Cathepsin D; Epidermal Growth Factor; Estradiol; Estrogen Antagonists; Growth Substances; Humans; Insulin-Like Growth Factor I; Neoplasm Proteins; Polyunsaturated Alkamides; Proteins; RNA, Messenger; Tamoxifen; Tetradecanoylphorbol Acetate; Transcription, Genetic; Trefoil Factor-1; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1993 |
Estrogen-inducible pS2 protein is not the key regulatory component in the proliferation of human breast cancer cells (MCF-7).
Topics: Biological Transport; Breast Neoplasms; Cell Division; Dactinomycin; DNA, Neoplasm; Estrogens; Genes, fos; Humans; Neoplasm Proteins; Protein Kinase C; Proteins; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Trefoil Factor-1; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1993 |
Characterization of high and low molecular weight forms of amphiregulin that differ in glycosylation and peptide core length. Evidence that the NH2-terminal region is not critical for bioactivity.
Topics: Amino Acid Sequence; Amphiregulin; Breast Neoplasms; Carbohydrate Conformation; Carbohydrate Sequence; Chemical Fractionation; Chromatography, Affinity; Chromatography, High Pressure Liquid; Culture Media, Conditioned; Disaccharides; EGF Family of Proteins; Epidermal Growth Factor; Glycoproteins; Glycosylation; Growth Substances; Heparin; Humans; Intercellular Signaling Peptides and Proteins; Molecular Sequence Data; Molecular Weight; N-Acetylneuraminic Acid; Oligosaccharides; Peptide Mapping; Sialic Acids; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
[The effect of progesterone and tamoxifen on EGF-dependent activation of phospholipid turnover in uterine and breast tumor cells].
Topics: Adenocarcinoma; Breast Neoplasms; Chromatography, Thin Layer; Epidermal Growth Factor; Estradiol; Female; Humans; Phospholipids; Phosphorus Radioisotopes; Progesterone; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Uterine Neoplasms | 1993 |
alpha 1-Antitrypsin- and anchorage-independent growth of MCF-7 breast cancer cells.
Topics: alpha 1-Antichymotrypsin; alpha 1-Antitrypsin; Breast Neoplasms; Cell Division; Culture Media; Epidermal Growth Factor; Humans; Interleukin-1; Interleukin-6; Tetradecanoylphorbol Acetate; Trypsin Inhibitors; Tumor Cells, Cultured | 1993 |
Growth arrest of the breast cancer cell line, T47D, by TNF alpha; cell cycle specificity and signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cell Cycle; Cell Division; DNA, Neoplasm; Ethers, Cyclic; Humans; Isoquinolines; Okadaic Acid; Piperazines; Protein Kinase C; Sensitivity and Specificity; Signal Transduction; Stimulation, Chemical; Sulfonamides; Tetradecanoylphorbol Acetate; Thymidine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate (TPA) and 17 beta-estradiol in MCF-7 human breast cancer cells.
Topics: Base Sequence; Breast Neoplasms; Cathepsin D; Cell Division; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Precursors; Estradiol; Gene Expression; Glucose; Humans; Kinetics; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oxidoreductases; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Receptors, Drug; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Regulation of phospholipid turnover by steroid hormones in endometrial carcinoma and breast cancer cells.
Topics: Adenocarcinoma; Breast Neoplasms; Endometrial Neoplasms; Epidermal Growth Factor; Estradiol; Female; Gonadal Steroid Hormones; Humans; Neoplasms, Hormone-Dependent; Phosphatidylcholines; Phosphatidylinositols; Phospholipids; Progesterone; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Potentiation of CYP1A1 gene expression in MCF-7 human breast cancer cells cotreated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 12-O-tetradecanoylphorbol-13-acetate.
Topics: Base Sequence; Breast Neoplasms; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; DNA-Binding Proteins; Female; Gene Expression Regulation, Enzymologic; Humans; In Vitro Techniques; Molecular Sequence Data; Nuclear Proteins; Oligodeoxyribonucleotides; Oxidoreductases; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Receptors, Drug; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 1993 |
Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Line; Enzyme Activation; Female; HL-60 Cells; Humans; Male; Paclitaxel; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-raf; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate and 17 beta-estradiol on estrogen receptor regulation in MCF-7 human breast cancer cells.
Topics: Breast Neoplasms; Carcinogens; Estradiol; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Polychlorinated Dibenzodioxins; Receptors, Estrogen; RNA, Messenger; Tetradecanoylphorbol Acetate | 1996 |
Tamoxifen modulates protein kinase C via oxidative stress in estrogen receptor-negative breast cancer cells.
Topics: Animals; Antioxidants; Breast Neoplasms; Cattle; Cell Division; Cell Membrane; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; In Vitro Techniques; Oxidative Stress; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rabbits; Receptors, Estrogen; Second Messenger Systems; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vitamin E | 1996 |
Post-translational cooperativity of ornithine decarboxylase induction by estrogens and peptide growth factors in human breast cancer cells.
Topics: Breast Neoplasms; Drug Synergism; Enzyme Induction; Estradiol; Estrogens; Female; Gene Expression Regulation, Enzymologic; Humans; Insulin; Insulin-Like Growth Factor I; Ornithine Decarboxylase; Protein Kinase C; Protein Processing, Post-Translational; Receptor, IGF Type 1; Receptors, Estrogen; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Regulation of arachidonic acid metabolism, aromatase activity and growth in human breast cancer cells by interleukin-1beta and phorbol ester: dissociation of a mediatory role for prostaglandin E2 in the autocrine control of cell function.
Topics: Arachidonic Acid; Aromatase; Breast Neoplasms; Cell Division; Dexamethasone; Dinoprostone; Enzyme Induction; Humans; Indomethacin; Interleukin-1; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Induction of apoptosis in MDA-231 cells by protein synthesis inhibitors is suppressed by multiple agents.
Topics: Alkaloids; Apoptosis; Breast Neoplasms; Cycloheximide; DNA; Epidermal Growth Factor; Female; Humans; Protein Biosynthesis; Protein Synthesis Inhibitors; Ricin; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Induction of a less aggressive breast cancer phenotype by protein kinase C-alpha and -beta overexpression.
Topics: Animals; Breast Neoplasms; Carcinoma; Cell Division; Cell Size; Female; Gene Expression; Isoenzymes; Mice; Mice, Nude; Phenotype; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vacuoles | 1996 |
Regulation of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in MCF-7 cells: comparison with regulatory mechanisms of pS2 expression.
Topics: Breast Neoplasms; Collagenases; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Matrix Metalloproteinase 1; Neoplasm Proteins; Protein Kinase C; Protein Synthesis Inhibitors; Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinases; Transcription, Genetic; Trefoil Factor-1; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1996 |
Evidence that intracellular phosphatidate may regulate breast cancer cell invasion and metastasis.
Topics: Breast Neoplasms; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Intracellular Fluid; Neoplasm Invasiveness; Phosphatidic Acids; Phospholipase D; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Differential expression and regulation of cyclooxygenase-1 and -2 in two human breast cancer cell lines.
Topics: Blotting, Northern; Breast Neoplasms; Carcinogens; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Female; Humans; Isoenzymes; Membrane Proteins; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Prostaglandin-Endoperoxide Synthases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene.
Topics: Adipose Tissue; Aromatase; Breast Neoplasms; Bucladesine; Colforsin; Cyclic AMP; Dinoprostone; Estrogens; Female; Gene Expression Regulation; Humans; Promoter Regions, Genetic; Stromal Cells; Tetradecanoylphorbol Acetate | 1996 |
Characterization of a novel amphiregulin-related molecule in 12-O-tetradecanoylphorbol-13-acetate-treated breast cancer cells.
Topics: Amphiregulin; Breast Neoplasms; Cell Compartmentation; EGF Family of Proteins; ErbB Receptors; Estradiol; Female; Glycoproteins; Glycosylation; Growth Substances; Heparin; Humans; Immunoenzyme Techniques; Intercellular Signaling Peptides and Proteins; Molecular Weight; Protein Binding; Protein Kinase C; Protein Processing, Post-Translational; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Defects in p21WAF1/CIP1, Rb, and c-myc signaling in phorbol ester-resistant cancer cells.
Topics: Breast Neoplasms; Carcinogens; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Down-Regulation; Drug Resistance; Female; Genes, myc; Humans; Male; Neoplasm Proteins; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-myc; Retinoblastoma Protein; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1997 |
Inhibition of phorbol ester-stimulated phospholipase D activity by chronic tamoxifen treatment in breast cancer cells.
Topics: 3T3 Cells; Animals; Breast Neoplasms; Estrogen Antagonists; Female; Humans; Mice; Phospholipase D; Protein Kinase C; Signal Transduction; Tamoxifen; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1997 |
Induction of metalloproteinase (MMP1) expression by epidermal growth factor (EGF) receptor stimulation and serum deprivation in human breast tumour cells.
Topics: Blotting, Northern; Breast Neoplasms; Collagenases; Culture Media, Serum-Free; Cycloheximide; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Matrix Metalloproteinase 1; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1996 |
Protein kinase C pathway potentiates androgen-mediated gene expression of the mouse vas deferens specific aldose reductase-like protein (MVDP).
Topics: Aldehyde Reductase; Animals; Breast Neoplasms; Bucladesine; Carcinoma; Cell Line; Chlorocebus aethiops; Cyclic AMP-Dependent Protein Kinases; Dihydrotestosterone; Enzyme Activation; Gene Expression Regulation; Humans; Male; Mammary Tumor Virus, Mouse; Mice; Promoter Regions, Genetic; Protein Kinase C; Proteins; Recombinant Fusion Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Vas Deferens | 1996 |
Retinoic acids increase 17 beta-hydroxysteroid dehydrogenase type 1 expression in JEG-3 and T47D cells, but the stimulation is potentiated by epidermal growth factor, 12-O-tetradecanoylphorbol-13-acetate, and cyclic adenosine 3',5'-monophosphate only in J
Topics: 17-Hydroxysteroid Dehydrogenases; Breast Neoplasms; Choriocarcinoma; Cyclic AMP; Drug Synergism; Epidermal Growth Factor; Female; Humans; Isoenzymes; Pregnancy; RNA, Messenger; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured; Uterine Neoplasms | 1997 |
Low-density lipoprotein receptor mRNA in human breast cancer cells: influence by PKC modulators.
Topics: Breast Neoplasms; Carcinogens; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Humans; Neoplasms, Hormone-Dependent; Protein Kinase C; Receptors, Estrogen; Receptors, LDL; Ribonucleases; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Retinoic acids differentially regulate NOR-1 and its closely related orphan nuclear receptor genes in breast cancer cell line MCF-7.
Topics: Alitretinoin; Breast Neoplasms; Colforsin; Cycloheximide; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Nerve Tissue Proteins; Nuclear Receptor Subfamily 4, Group A, Member 1; Nuclear Receptor Subfamily 4, Group A, Member 2; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Receptors, Thyroid Hormone; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factors; Tretinoin; Tumor Cells, Cultured | 1997 |
Phosphorylation of A 27-kDa protein correlates with survival of protein-synthesis-inhibited MCF-7 cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aurintricarboxylic Acid; Breast Neoplasms; Carcinoma; Cell Survival; Cycloheximide; Cytosol; Epidermal Growth Factor; Heat-Shock Proteins; Humans; Insulin-Like Growth Factor I; Isoelectric Point; Mitogens; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphoserine; Protein Synthesis Inhibitors; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1997 |
X-ray-mediated reduction in basic fibroblast growth factor expression in primary rat astrocyte cultures.
Topics: Amino Acid Isomerases; Animals; Astrocytes; Breast Neoplasms; Carrier Proteins; Cells, Cultured; Cerebral Cortex; Ciliary Neurotrophic Factor; Embryo, Mammalian; Female; Fibroblast Growth Factor 2; Glial Fibrillary Acidic Protein; Humans; Kinetics; Nerve Tissue Proteins; Peptidylprolyl Isomerase; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1997 |
Activity of retinoic acid receptor-gamma selectively binding retinoids alone and in combination with interferon-gamma in breast cancer cell lines.
Topics: Binding, Competitive; Breast Neoplasms; Cell Division; Cell Line; Chloramphenicol O-Acetyltransferase; Female; Humans; Interferon-gamma; Promoter Regions, Genetic; Receptors, Retinoic Acid; Recombinant Fusion Proteins; Retinoic Acid Receptor gamma; Retinoids; RNA, Messenger; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tretinoin; Tumor Cells, Cultured | 1997 |
Mechanism of inhibition of MDA-MB-468 breast cancer cell growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Topics: Aryl Hydrocarbon Receptor Nuclear Translocator; Breast Neoplasms; Cell Division; Cell Nucleus; Cytochrome P-450 CYP1A1; Diethylstilbestrol; DNA-Binding Proteins; DNA, Neoplasm; Estradiol; Female; Gene Expression Regulation, Neoplastic; Genes, myc; Growth Inhibitors; Humans; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Receptors, Estrogen; Tetradecanoylphorbol Acetate; Transcription Factors; Transforming Growth Factor alpha; Tretinoin; Tumor Cells, Cultured | 1997 |
Regulation of c-fos and c-jun expression by calcitonin in human breast cancer cells.
Topics: Blotting, Northern; Breast Neoplasms; Calcitonin; Carcinogens; Cell Division; Colforsin; Dose-Response Relationship, Drug; Drug Interactions; Epidermal Growth Factor; Female; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, jun; Glycoproteins; Humans; Insulin; Isoquinolines; Metalloendopeptidases; Protein Biosynthesis; Protein Kinase Inhibitors; Proteins; Receptors, Calcitonin; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-2; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured | 1997 |
Identification of a motif within the 5' regulatory region of pS2 which is responsible for AP-1 binding and TCDD-mediated suppression.
Topics: Base Sequence; Breast Neoplasms; DNA Mutational Analysis; DNA-Binding Proteins; Estradiol; Female; Gene Expression Regulation, Neoplastic; Humans; Molecular Sequence Data; Polychlorinated Dibenzodioxins; Protein Binding; Proteins; Receptors, Aryl Hydrocarbon; Receptors, Estrogen; Regulatory Sequences, Nucleic Acid; Sequence Deletion; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Trefoil Factor-1; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1997 |
Csa-19, a radiation-responsive human gene, identified by an unbiased two-gel cDNA library screening method in human cancer cells.
Topics: Age Factors; Blotting, Northern; Breast Neoplasms; Cloning, Molecular; Colforsin; Cyclosporine; DNA, Complementary; Dose-Response Relationship, Radiation; Down-Regulation; Gene Expression Regulation, Developmental; Gene Library; Genes, p53; HL-60 Cells; Humans; Molecular Sequence Data; Neutrons; Oncogenes; Tetradecanoylphorbol Acetate; Tissue Distribution; Tumor Cells, Cultured; X-Rays | 1997 |
Retinyl methyl ether down-regulates activator protein 1 transcriptional activation in breast cancer cells.
Topics: Breast Neoplasms; Carcinogens; Collagenases; DNA-Binding Proteins; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; Genes, Reporter; HeLa Cells; Humans; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Retinoic Acid; Retinoid X Receptors; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factors; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Vitamin A | 1997 |
Changes in the phosphorylation status of the 27 kDa heat shock protein (HSP27) associated with the modulation of growth and/or differentiation in MCF-7 cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Electrophoresis, Gel, Two-Dimensional; Female; Heat-Shock Proteins; Humans; Mitogen-Activated Protein Kinases; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1997 |
Modulation of human stromelysin 3 promoter activity and gene expression by human breast cancer cells.
Topics: 3T3 Cells; Animals; Blotting, Northern; Breast Neoplasms; Cell Line, Transformed; Cytokines; Female; Gene Expression Regulation, Enzymologic; Humans; Matrix Metalloproteinase 11; Metalloendopeptidases; Mice; Promoter Regions, Genetic; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transcriptional Activation; Tumor Cells, Cultured; Up-Regulation | 1997 |
Differential effects of 1,25-dihydroxyvitamin D3 and tetradecanoylphorbol acetate on cell cycle and apoptosis of MCF-7 cells and a vitamin D3-resistant variant.
Topics: Apoptosis; Breast Neoplasms; Calcitriol; Cell Count; Cell Cycle; Cell Cycle Proteins; Cholecalciferol; Drug Resistance; Female; Genetic Variation; Humans; Receptors, Calcitriol; Receptors, Estrogen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Regulation of collagenase-3 expression in human breast carcinomas is mediated by stromal-epithelial cell interactions.
Topics: Breast Neoplasms; Carcinogens; Carcinoma, Ductal, Breast; Cell Communication; Collagenases; Culture Media, Conditioned; Cytokines; Epithelium; Female; Fibroblasts; Humans; In Situ Hybridization; Interleukin-1; Matrix Metalloproteinase 13; Neoplasm Proteins; RNA, Messenger; Stromal Cells; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Re-expression of elafin in 21MT2 breast carcinomas by phorbol 12-myristate 13-acetate is mediated by the Ap1 site in the elafin promoter.
Topics: Binding Sites; Breast; Breast Neoplasms; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Promoter Regions, Genetic; Protein Biosynthesis; Proteinase Inhibitory Proteins, Secretory; Proteins; Recombinant Fusion Proteins; Serine Proteinase Inhibitors; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1997 |
Induction of retinoid resistance in breast cancer cells by overexpression of cJun.
Topics: Breast Neoplasms; Cell Division; Drug Resistance, Neoplasm; Female; Genes, jun; Genes, Reporter; Humans; Kinetics; Polymerase Chain Reaction; Proto-Oncogene Proteins c-jun; Receptors, Retinoic Acid; Recombinant Fusion Proteins; Retinoic Acid Receptor alpha; Retinoid X Receptors; Retinoids; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tretinoin; Tumor Cells, Cultured | 1997 |
Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase.
Topics: Breast Neoplasms; Cell Division; Chromones; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Replication; Enzyme Inhibitors; Female; Flavonoids; G1 Phase; Humans; Insulin-Like Growth Factor I; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Retinoblastoma Protein; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Effects of epidermal growth factor and estrogen on the regulation of the HMG-I/Y gene in human mammary epithelial cell lines.
Topics: Breast Neoplasms; Chromosome Mapping; DNA, Neoplasm; Epidermal Growth Factor; Estrogens; Female; Gene Expression; High Mobility Group Proteins; HMGA1a Protein; Humans; Neoplasm Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1997 |
A GPIb alpha-related protein is expressed by fresh human breast carcinoma tissue and is regulated by a PKC-sensitive mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Breast; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Enzyme Inhibitors; Female; Humans; Immunohistochemistry; Kinetics; Neoplasm Invasiveness; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Protein Kinase C; Reference Values; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Taxol-induced p34cdc2 kinase activation and apoptosis inhibited by 12-O-tetradecanoylphorbol-13-acetate in human breast MCF-7 carcinoma cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; CDC2 Protein Kinase; Enzyme Activation; Humans; Paclitaxel; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
ZR-75-1 human breast cancer cells: expression of inducible nitric oxide synthase and effect of tamoxifen and phorbol ester on nitric oxide production.
Topics: Arginine; Breast Neoplasms; Female; Humans; Immunoenzyme Techniques; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
The role of MAP kinase in TPA-mediated cell cycle arrest of human breast cancer cells.
Topics: Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Enzyme Activation; Enzyme Inhibitors; Flavonoids; G1 Phase; Genes, Reporter; Humans; Insulin; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-jun; Retinoblastoma Protein; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
NGF, cyclic AMP, and phorbol esters regulate oxytocin receptor gene transcription in SK-N-SH and MCF7 cells.
Topics: Animals; Brain; Breast Neoplasms; Cloning, Molecular; Colforsin; Cyclic AMP; DNA-Binding Proteins; Female; Humans; Nerve Growth Factors; Neuroblastoma; Promoter Regions, Genetic; Rats; Receptors, Oxytocin; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1998 |
Breast cancer cell invasiveness: correlation with protein kinase C activity and differential regulation by phorbol ester in estrogen receptor-positive and -negative cells.
Topics: Breast Neoplasms; Carcinoma; Chemotaxis; Collagen; Drug Combinations; Female; Humans; In Vitro Techniques; Laminin; Neoplasm Invasiveness; Protein Kinase C; Proteoglycans; Receptors, Estrogen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Gap junction Cx26 gene modulation by phorbol esters in benign and malignant human mammary cells.
Topics: Base Sequence; Breast; Breast Neoplasms; Cell Line, Transformed; Chloramphenicol O-Acetyltransferase; Connexin 26; Connexins; Deoxyribonuclease I; Enzyme Inhibitors; Epithelial Cells; Female; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Molecular Sequence Data; Naphthalenes; Protein Biosynthesis; Protein Kinase C; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1998 |
Protein kinase C epsilon translocation and phosphorylation by cis-diamminedichloroplatinum(II) (CDDP): potential role in CDDP-mediated cytotoxicity.
Topics: Antineoplastic Agents; Biological Transport; Breast Neoplasms; Carboplatin; Carcinoma; Cisplatin; Cytosol; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Humans; Isoenzymes; Microcystins; Nuclear Envelope; Oligonucleotides, Antisense; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Protein Phosphatase 2; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Regulation of tissue-degrading factors and in vitro invasiveness in progression of breast cancer cells.
Topics: Breast Neoplasms; Cell Movement; Extracellular Matrix; Female; Gene Expression Regulation, Neoplastic; Humans; Metalloendopeptidases; Neoplasm Invasiveness; Plasminogen Activator Inhibitor 1; Protein Kinase C; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1998 |
Association of PKC delta and active Src in PMA-treated MCF-7 human breast cancer cells.
Topics: Breast Neoplasms; Cell Extracts; Cell Fractionation; Enzyme Activation; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Isoenzymes; Mitogens; Molecular Chaperones; Neoplasm Proteins; Oncogene Protein pp60(v-src); Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Tyrosine | 1998 |
Activation of tissue-factor gene expression in breast carcinoma cells by stimulation of the RAF-ERK signaling pathway.
Topics: Base Sequence; Benzoquinones; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Dactinomycin; DNA, Complementary; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Genistein; Humans; Hydroquinones; Lactams, Macrocyclic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neovascularization, Pathologic; NF-kappa B; Okadaic Acid; Phenols; Proto-Oncogene Proteins c-raf; Quinones; Rifabutin; Signal Transduction; Tetradecanoylphorbol Acetate; Thromboplastin; Transcription Factor AP-1; Transcription, Genetic; Tretinoin; Tumor Cells, Cultured | 1998 |
Phorbol ester stimulation of phosphatidylcholine synthesis requires expression of both protein kinase C-alpha and phospholipase D.
Topics: 3T3 Cells; 9,10-Dimethyl-1,2-benzanthracene; Animals; Breast Neoplasms; Choline; Choline Kinase; Diglycerides; Enzyme Activation; Female; Humans; Isoenzymes; Mice; Phosphatidylcholines; Protein Kinase C; Protein Kinase C-alpha; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Type C Phospholipases | 1998 |
Differential effects of protein kinase C agonists on prostaglandin production and growth in human breast cancer cells.
Topics: Antineoplastic Agents; Arachidonic Acid; Breast Neoplasms; Bryostatins; Cell Division; Dinoprostone; Enzyme Activation; Female; Humans; Lactones; Macrolides; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
1,25-Dihydroxyvitamin D3 inhibits tenascin-C expression in mammary epithelial cells.
Topics: Animals; Breast Neoplasms; Calcitriol; Carcinogens; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Neoplasm Proteins; RNA, Messenger; RNA, Neoplasm; Tenascin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Staurosporine-induced versus spontaneous squamous metaplasia in pre- and postmenopausal breast tissue.
Topics: Adult; Aged; Anticarcinogenic Agents; Breast; Breast Neoplasms; Carcinogens; Carcinoma, Squamous Cell; Cell Differentiation; Cell Division; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Immunophenotyping; Keratin-10; Keratinocytes; Keratins; Middle Aged; Naphthalenes; Postmenopause; Premenopause; Protein Kinase C; Staurosporine; Tamoxifen; Tetradecanoylphorbol Acetate; Thrombomodulin; Tumor Cells, Cultured; Up-Regulation | 1998 |
12-O-tetradecanoylphorbol-13-acetate upregulates the Ah receptor and differentially alters CYP1B1 and CYP1A1 expression in MCF-7 breast cancer cells.
Topics: Aryl Hydrocarbon Hydroxylases; Biomarkers; Breast Neoplasms; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; Estradiol; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Polychlorinated Dibenzodioxins; Polymerase Chain Reaction; Receptors, Aryl Hydrocarbon; Receptors, Estrogen; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1998 |
Regulation of Wnt5a expression in human mammary cells by protein kinase C activity and the cytoskeleton.
Topics: Breast; Breast Neoplasms; Cadherins; Cell Line, Transformed; Cytoskeleton; Enzyme Inhibitors; Female; Gene Expression Regulation; Half-Life; Humans; Phosphoric Monoester Hydrolases; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Wnt Proteins; Wnt-5a Protein | 1998 |
Regulation of a promoter of the fibroblast growth factor 1 gene in prostate and breast cancer cells.
Topics: Androgens; Base Sequence; Blood; Breast Neoplasms; Cell Line; Consensus Sequence; DNA, Complementary; Fibroblast Growth Factor 1; Gene Expression Regulation, Neoplastic; Humans; Male; Molecular Sequence Data; Promoter Regions, Genetic; Prostatic Neoplasms; RNA, Messenger; Sequence Analysis; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1998 |
Phorbol ester-induced P-glycoprotein phosphorylation and functionality in the HTB-123 human breast cancer cell line.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Breast Neoplasms; Carcinogens; Doxorubicin; Humans; Phosphorylation; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Inhibitory effects of an antiestrogen, toremifene, on the phorbol ester-induced adhesive capacity of breast carcinoma cells.
Topics: Breast Neoplasms; Carcinogens; Carcinoma; Cell Adhesion; Enzyme Repression; Estrogen Antagonists; Humans; Protein Kinase C; Tetradecanoylphorbol Acetate; Toremifene; Tumor Cells, Cultured | 1998 |
NADH: ubiquinone oxidoreductase inhibitors block induction of ornithine decarboxylase activity in MCF-7 human breast cancer cells.
Topics: Breast Neoplasms; Electron Transport Complex I; Enzyme Induction; Epithelial Cells; Estradiol; Female; Humans; Insulin-Like Growth Factor I; NADH, NADPH Oxidoreductases; Ornithine Decarboxylase; Quinazolines; RNA, Messenger; Rotenone; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Uncoupling Agents | 1998 |
Inhibition of AP-1 and NF-kappaB by manganese-containing superoxide dismutase in human breast cancer cells.
Topics: Breast Neoplasms; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Manganese; NF-kappa B; Recombinant Proteins; Signal Transduction; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Cells, Cultured | 1998 |
Regulation of c-fos transcription by chemopreventive isoflavonoids and lignans in MDA-MB-468 breast cancer cells.
Topics: Breast Neoplasms; Carcinogens; Female; Genes, fos; Humans; Isoflavones; Lignans; Masoprocol; Protein Kinase C; Protein-Tyrosine Kinases; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1998 |
Induction of apoptosis in breast cancer cells by TPA.
Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Northern; Blotting, Western; Breast Neoplasms; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Fragmentation; Flow Cytometry; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Molecular Weight; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1998 |
Phorbol 12-myristate 13-acetate stimulates lysophosphatidic acid secretion from ovarian and cervical cancer cells but not from breast or leukemia cells.
Topics: Breast Neoplasms; Carcinogens; Dose-Response Relationship, Drug; Female; Humans; Leukemia; Lysophospholipids; Ovarian Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 1998 |
Determination of the enzymes responsible for activation of the heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline in the human breast.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Adult; Biotransformation; Breast; Breast Neoplasms; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Epithelial Cells; Female; Humans; In Vitro Techniques; Indomethacin; Neutrophils; Quinolines; Reverse Transcriptase Polymerase Chain Reaction; Sodium Azide; Tetradecanoylphorbol Acetate | 1998 |
Transcriptional regulation of the oxytocin receptor gene.
Topics: Breast Neoplasms; Colforsin; Dexamethasone; Estrogens; Female; Gene Expression Regulation; Genes, Reporter; Humans; Mutagenesis, Site-Directed; Nerve Growth Factors; Promoter Regions, Genetic; Receptors, Oxytocin; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1998 |
Macrophages, estrogen and the microenvironment of breast cancer.
Topics: Antineoplastic Agents; Aromatase; Breast; Breast Neoplasms; Carcinoma in Situ; Cell Division; Cell Line; Enzyme Inhibitors; Estradiol; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hyperplasia; Immunohistochemistry; Letrozole; Macrophages; Monocytes; Nitriles; Placenta; Pregnancy; Testosterone; Tetradecanoylphorbol Acetate; Transcription, Genetic; Triazoles | 1998 |
Regulation of motility and protease expression in PKC-mediated induction of MCF-7 breast cancer cell invasiveness.
Topics: Breast Neoplasms; Bryostatins; Cathepsin D; Cell Movement; Endopeptidases; Enzyme Activation; Humans; Lactones; Macrolides; Metalloendopeptidases; Neoplasm Invasiveness; Protein Kinase C; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1999 |
Imaging protein kinase Calpha activation in cells.
Topics: 3T3 Cells; Animals; Breast Neoplasms; Catalysis; COS Cells; Cytoplasm; Endoplasmic Reticulum; Energy Transfer; Enzyme Activation; Fluorescence; Fluorescent Dyes; Golgi Apparatus; Green Fluorescent Proteins; Humans; Immune Sera; Isoenzymes; Luminescent Proteins; Mice; Microscopy, Fluorescence; Phosphorylation; Phosphothreonine; Protein Kinase C; Protein Kinase C-alpha; Tetradecanoylphorbol Acetate; Transfection | 1999 |
Activation of protein kinase C by phorbol esters modulates alpha2beta1 integrin on MCF-7 breast cancer cells.
Topics: ADP Ribose Transferases; Animals; Botulinum Toxins; Breast Neoplasms; Cell Adhesion; Enzyme Activation; Enzyme Inhibitors; Female; Gene Expression Regulation; Humans; Integrins; Mice; Naphthalenes; Protein Kinase C; Rats; Receptors, Collagen; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Overexpression of c-Myc inhibits p21WAF1/CIP1 expression and induces S-phase entry in 12-O-tetradecanoylphorbol-13-acetate (TPA)-sensitive human cancer cells.
Topics: Adenoviridae; Apoptosis; Blotting, Western; Breast Neoplasms; Bromodeoxyuridine; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Kinetics; Luciferases; Male; Prostatic Neoplasms; Proto-Oncogene Proteins c-myc; S Phase; Tetradecanoylphorbol Acetate; Thymidine; Time Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1999 |
Identification of a novel class of retinoic acid receptor beta-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells.
Topics: Animals; Apoptosis; Benzoates; Benzodiazepines; Breast Neoplasms; Collagenases; Dimerization; Drug Design; Genes, Reporter; HeLa Cells; Humans; Promoter Regions, Genetic; Receptors, Retinoic Acid; Retinoid X Receptors; Retinoids; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factors; Transcriptional Activation; Transfection; Tretinoin; Tumor Cells, Cultured | 1999 |
Overexpression of protein kinase C-alpha in MCF-7 breast cancer cells results in differential regulation and expression of alphavbeta3 and alphavbeta5.
Topics: Animals; Breast Neoplasms; Cell Adhesion; Dimerization; Enzyme Induction; Female; Gene Expression Regulation, Neoplastic; Humans; Integrins; Isoenzymes; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Transplantation; Osteopontin; Protein Kinase C; Protein Kinase C-alpha; Receptors, Vitronectin; Recombinant Fusion Proteins; Sialoglycoproteins; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Vitronectin | 1999 |
Activation of proMMP-9 by a plasmin/MMP-3 cascade in a tumor cell model. Regulation by tissue inhibitors of metalloproteinases.
Topics: Basement Membrane; Breast Neoplasms; Collagenases; Enzyme Activation; Enzyme Precursors; Female; Fibrinolysin; Humans; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Models, Biological; Neoplasm Invasiveness; Recombinant Proteins; Sequence Deletion; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured | 1999 |
Re-expression of SPR1 in breast cancer cells by phorbol 12-myristate 13-acetate (PMA) or UV irradiation is mediated by the AP-1 binding site in the SPR1 promoter.
Topics: Base Sequence; Binding Sites; Breast; Breast Neoplasms; Cell Line; Chloramphenicol O-Acetyltransferase; Cornified Envelope Proline-Rich Proteins; Epithelial Cells; Female; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Membrane Proteins; Molecular Sequence Data; Promoter Regions, Genetic; Proteins; Recombinant Fusion Proteins; RNA, Messenger; Sequence Deletion; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Ultraviolet Rays | 1999 |
Reduced expression of endothelial and inducible nitric oxide synthase in a human breast cancer cell line which has acquired estrogen independence.
Topics: Animals; Breast Neoplasms; Cattle; Estrogens; Female; Humans; Immunohistochemistry; Mifepristone; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Progesterone; Rabbits; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Differential effect of retinoic acid on growth regulation by phorbol ester in human cancer cell lines.
Topics: Breast Neoplasms; Cell Cycle; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Mitogen-Activated Protein Kinases; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tretinoin; Tumor Cells, Cultured | 1999 |
Phosphorylation of murine p53, but not human p53, by MAP kinase in vitro and in cultured cells highlights species-dependent variation in post-translational modification.
Topics: Adenosine Triphosphate; Amino Acid Motifs; Amino Acid Substitution; Animals; Breast Neoplasms; Cells, Cultured; Dimethyl Sulfoxide; Glutathione Transferase; Humans; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Recombinant Proteins; Species Specificity; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 1999 |
Multiple signaling pathways mediate interleukin-4-induced 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene expression in human breast cancer cells.
Topics: Androstadienes; Breast Neoplasms; Chromones; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Interleukin-4; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase Kinases; Morpholines; Multienzyme Complexes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Progesterone Reductase; Signal Transduction; STAT6 Transcription Factor; Steroid Isomerases; Tetradecanoylphorbol Acetate; Trans-Activators; Tumor Cells, Cultured; Wortmannin | 2000 |
Role of Src kinases in the ADAM-mediated release of L1 adhesion molecule from human tumor cells.
Topics: Animals; Antigens, Surface; Breast Neoplasms; Cell Size; CHO Cells; Cricetinae; Disintegrins; Enzyme Inhibitors; Female; Flavonoids; Humans; Leukocyte L1 Antigen Complex; Membrane Glycoproteins; Metalloendopeptidases; Mice; Neural Cell Adhesion Molecules; Neuroblastoma; Phosphorylation; Protease Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Recombinant Proteins; Signal Transduction; src-Family Kinases; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Vanadates | 2000 |
Unique anti-activator protein-1 activity of retinoic acid receptor beta.
Topics: Breast Neoplasms; Carcinogens; Cell Division; Collagenases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genes, Reporter; HeLa Cells; Histone Deacetylases; Humans; Hydroxamic Acids; Mutagenesis; Plasmids; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Reverse Transcriptase Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transfection; Tretinoin; Tumor Cells, Cultured | 2000 |
Method for cloning in vivo targets of the Egr-1 transcription factor.
Topics: Binding Sites; Breast Neoplasms; Cloning, Molecular; Cross-Linking Reagents; DNA; DNA-Binding Proteins; Early Growth Response Protein 1; Fibrosarcoma; Formaldehyde; Gene Expression; Humans; Immediate-Early Proteins; Immunosorbent Techniques; Polymerase Chain Reaction; Sensitivity and Specificity; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured | 2000 |
Loss of cell cycle control allows selective microtubule-active drug-induced Bcl-2 phosphorylation and cytotoxicity in autonomous cancer cells.
Topics: Apoptosis; Breast Neoplasms; Cell Cycle; Cell Division; Cell Survival; Enzyme Inhibitors; Epidermal Growth Factor; Female; HL-60 Cells; Humans; Microtubules; Mitosis; Paclitaxel; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tetradecanoylphorbol Acetate; Tubulin; Tumor Cells, Cultured; Tyrphostins | 2000 |
Stabilization of cyclin D1 mRNA via the phosphatidylinositol 3-kinase pathway in MCF-7 human breast cancer cells.
Topics: Blotting, Northern; Blotting, Western; Breast Neoplasms; Chromones; Cyclin D1; Enzyme Inhibitors; Epidermal Growth Factor; Estradiol; Female; Gene Expression; Half-Life; Humans; Insulin-Like Growth Factor I; Morpholines; Phosphoinositide-3 Kinase Inhibitors; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Adherence to osteopontin via alphavbeta3 suppresses phorbol ester-mediated apoptosis in MCF-7 breast cancer cells that overexpress protein kinase C-alpha.
Topics: Adenocarcinoma; Antigens, CD; Apoptosis; Bone Neoplasms; Breast Neoplasms; Cell Adhesion; Enzyme Induction; Extracellular Matrix Proteins; Female; Gene Expression Regulation, Neoplastic; Humans; Integrin beta3; Isoenzymes; Neoplasm Invasiveness; Neoplasm Proteins; Oligopeptides; Osteopontin; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Kinase C-alpha; Receptors, Vitronectin; Sialoglycoproteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Myoepithelial-specific CD44 shedding contributes to the anti-invasive and antiangiogenic phenotype of myoepithelial cells.
Topics: Antigens, CD; Breast Neoplasms; Carcinoma; Culture Media, Conditioned; Epithelial Cells; Female; Humans; Hyaluronan Receptors; Neoplasm Invasiveness; Neovascularization, Pathologic; Protease Inhibitors; Protein Isoforms; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1; Tumor Cells, Cultured; Tunicamycin | 2000 |
Extracellular ATP activates multiple signalling pathways and potentiates growth factor-induced c-fos gene expression in MCF-7 breast cancer cells.
Topics: Adenosine Triphosphate; Anisomycin; Breast Neoplasms; Carcinogens; Epidermal Growth Factor; Female; Gene Expression Regulation, Neoplastic; Genes, fos; Growth Substances; Humans; Parathyroid Hormone-Related Protein; Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transforming Growth Factor beta; Tumor Cells, Cultured | 2000 |
Identification of a novel AU-Rich element in the 3' untranslated region of epidermal growth factor receptor mRNA that is the target for regulated RNA-binding proteins.
Topics: 3' Untranslated Regions; Base Sequence; Breast Neoplasms; Cytoplasm; DNA Mutational Analysis; Epidermal Growth Factor; ErbB Receptors; Humans; Molecular Sequence Data; Regulatory Sequences, Nucleic Acid; RNA Stability; RNA-Binding Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 2001 |
Human neutrophils facilitate tumor cell transendothelial migration.
Topics: Adenocarcinoma; Adult; Antibodies, Monoclonal; Apoptosis; Breast Neoplasms; Capillaries; Carcinogens; Cell Division; Cell Movement; Culture Media, Conditioned; Endothelium, Vascular; Female; Flow Cytometry; Humans; Integrin beta1; Intercellular Adhesion Molecule-1; Lipopolysaccharides; Neoplasm Metastasis; Neutralization Tests; Neutrophils; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Umbilical Veins | 2001 |
Novel vitamin D(3) analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D(3), that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Calcitriol; Carcinoma; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Division; Cyclin-Dependent Kinase Inhibitor p27; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Leukemic; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; Leukemia, Myeloid; Male; Microtubule-Associated Proteins; Neoplasm Proteins; Phosphoric Monoester Hydrolases; Prostatic Neoplasms; PTEN Phosphohydrolase; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2001 |
Expression and in vitro modification of parathyroid hormone-related protein (PTHrP) and PTH/PTHrP-receptor in human myeloma cells.
Topics: Aged; Bone Marrow; Breast Neoplasms; Cytokines; Female; Humans; Male; Middle Aged; Multiple Myeloma; Parathyroid Hormone-Related Protein; Proteins; Receptor, Parathyroid Hormone, Type 1; Receptors, Parathyroid Hormone; RNA; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured | 2001 |
Regulation of MDR1 promoter activity in human breast carcinoma cells by protein kinase C isozymes alpha and theta.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Breast Neoplasms; Catalysis; Chloramphenicol O-Acetyltransferase; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Deletion; Gene Expression Regulation, Enzymologic; Genes, Reporter; Humans; Indoles; Isoenzymes; Maleimides; Phenotype; Promoter Regions, Genetic; Protein Isoforms; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-theta; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2001 |
The nuclear factor kappa B (NF-kappa B): a potential therapeutic target for estrogen receptor negative breast cancers.
Topics: Animals; Base Sequence; Breast Neoplasms; Carbazoles; Cell Division; Cyclin D1; DNA Primers; Enzyme Inhibitors; Female; Humans; I-kappa B Kinase; Indoles; Mammary Neoplasms, Experimental; Mice; Mice, Inbred A; Mutation; NF-kappa B; Protein Kinase C; Protein Serine-Threonine Kinases; Receptors, Estrogen; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 2001 |
A role for protein kinase C delta in the differential sensitivity of MCF-7 and MDA-MB 231 human breast cancer cells to phorbol ester-induced growth arrest and p21(WAFI/CIP1) induction.
Topics: Acetophenones; Animals; Benzopyrans; Blotting, Western; Breast Neoplasms; Carcinogens; Cell Division; Cell Membrane; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cytosol; Detergents; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; Isoenzymes; Luciferases; Octoxynol; Plasmids; Protein Isoforms; Protein Kinase C; Protein Kinase C-delta; Rats; Receptors, Estrogen; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 2001 |
Dynamic chromatin remodeling on the HER2 promoter in human breast cancer cells.
Topics: Acetylation; Base Sequence; Breast Neoplasms; Chromatin; DNA Primers; Female; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Okadaic Acid; Phosphorylation; Promoter Regions, Genetic; Serine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
Expression and regulation of Cyr61 in human breast cancer cell lines.
Topics: Active Transport, Cell Nucleus; Adenocarcinoma; Breast Neoplasms; Calcitriol; Cysteine-Rich Protein 61; Drug Resistance; Estradiol; Estrogen Receptor Modulators; Estrogens; Female; Fulvestrant; Gene Expression Regulation, Neoplastic; Genes, Immediate-Early; Growth Substances; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Phenotype; Protein Structure, Tertiary; Receptors, Estrogen; RNA, Messenger; RNA, Neoplasm; Selective Estrogen Receptor Modulators; Tamoxifen; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection; Tretinoin; Tumor Cells, Cultured | 2002 |
Effect of prolonged hydroxytamoxifen treatment of MCF-7 cells on mitogen activated kinase cascade.
Topics: Anisomycin; Anti-Bacterial Agents; Breast Neoplasms; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Genes, ras; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-raf; Receptors, Estrogen; Recombinant Proteins; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2002 |
Protein kinase C involvement in proliferation and survival of breast cancer cells.
Topics: Apoptosis; Breast Neoplasms; Cell Division; Cell Line; Cell Survival; Enzyme Activators; Enzyme Inhibitors; Female; Humans; Immunohistochemistry; Indoles; Maleimides; Neoplasm Proteins; Protein Kinase C; Tetradecanoylphorbol Acetate | 2002 |
Evidence for a role for protein kinase C in the modulation of bombesin-activated cellular signalling in human breast cancer cells.
Topics: Bombesin; Breast Neoplasms; Calcium; Cytidine Diphosphate Diglycerides; Down-Regulation; Humans; Hydrolysis; Phosphatidylinositols; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Collagen-induced activation of the M(r) 72,000 type IV collagenase in normal and malignant human fibroblastoid cells.
Topics: Breast Neoplasms; Carcinosarcoma; Collagen; Concanavalin A; Enzyme Induction; Fibroblasts; Humans; Matrix Metalloproteinase 9; Microbial Collagenase; Molecular Weight; Phenylmercuric Acetate; Skin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Transcriptional downregulation of gap-junction proteins blocks junctional communication in human mammary tumor cell lines.
Topics: Amino Acid Sequence; Animals; Base Sequence; Breast; Breast Neoplasms; Cell Communication; Cell Cycle; Cell Line; Connexin 26; Connexins; Cycloheximide; Dactinomycin; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Intercellular Junctions; Membrane Proteins; Molecular Sequence Data; Nucleic Acid Hybridization; Rats; Sequence Homology, Nucleic Acid; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Differentiation induction in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A.
Topics: Antibodies, Monoclonal; Autoradiography; Blotting, Northern; Breast Neoplasms; Caseins; Cell Differentiation; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Female; Fluorescent Antibody Technique; Gene Expression; Genes, fos; Genes, jun; Humans; Isoenzymes; Kinetics; Marine Toxins; Microcystins; Okadaic Acid; Oligonucleotide Probes; Oxazoles; Peptides, Cyclic; Phosphates; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Pyrans; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Modulation of the antigenic phenotype of human breast carcinoma cells by modifiers of protein kinase C activity and recombinant human interferons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzyl Alcohols; Breast Neoplasms; Carcinoma; Cell Adhesion Molecules; Cell Division; Diterpenes; Female; Glycoproteins; Histocompatibility Antigens Class II; Humans; Intercellular Adhesion Molecule-1; Interferon Type I; Interferon-gamma; Isoquinolines; Phenotype; Piperazines; Protein Kinase C; Proto-Oncogene Proteins; Receptor, ErbB-2; Recombinant Proteins; Terpenes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Down-regulation of messenger ribonucleic acid (mRNA) for the estrogen receptor (ER) by phorbol ester requires ongoing RNA synthesis but not protein synthesis. Is hormonal control of ER mRNA degradation mediated by an RNA molecule?
Topics: Breast Neoplasms; Carcinoma; Cycloheximide; Dactinomycin; Dichlororibofuranosylbenzimidazole; Hormones; Humans; Puromycin; Receptors, Estrogen; RNA; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Effects of differentiating agents on cell surface expression of the breast carcinoma-associated DF3-P epitope.
Topics: Antigens, Neoplasm; Breast Neoplasms; Butyrates; Butyric Acid; Cell Differentiation; Epitopes; Flow Cytometry; Humans; Immunoblotting; Phenotype; Radioimmunoassay; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
12-O-tetradecanoylphorbol-13-acetate induces transient cell cycle arrest in G1 and G2 in metastatic melanoma cells: inhibition of phosphorylation of p34cdc2.
Topics: Breast Neoplasms; CDC2 Protein Kinase; Cell Division; Depression, Chemical; DNA Replication; Humans; Interphase; Male; Melanoma; Middle Aged; Neoplasm Proteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Antiproliferative effect of phorbol esters on MCF-7 human breast adenocarcinoma cells: relationship with enhanced expression of transforming growth-factor-beta 1.
Topics: Adenocarcinoma; Breast Neoplasms; Cell Division; Enzyme Activation; Humans; Plasmids; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured; Up-Regulation | 1992 |
[Regulation by protein kinase C of TGF-beta 1 expression in cultured cells of breast adenocarcinoma].
Topics: Adenocarcinoma; Breast Neoplasms; Female; Gene Expression Regulation, Enzymologic; Humans; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured | 1992 |
Elevated level of nuclear protein kinase C in multidrug-resistant MCF-7 human breast carcinoma cells.
Topics: Amino Acid Sequence; Blotting, Western; Breast Neoplasms; Cell Nucleus; Chromatography, DEAE-Cellulose; Doxorubicin; Drug Resistance; Female; Humans; Immunohistochemistry; Molecular Sequence Data; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Interleukin-6 and 12-O-tetradecanoyl phorbol-13-acetate act synergistically in inducing cell-cell separation and migration of human breast carcinoma cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Antibodies, Monoclonal; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cell Line; Cell Movement; Cytokines; DNA Replication; Drug Synergism; Female; Floxuridine; Growth Substances; Humans; Interleukin-6; Methotrexate; Protein Kinase C; Recombinant Proteins; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
K562 erythroleukemia cells express cytokeratins 8, 18, and 19 and epithelial membrane antigen that disappear after induced differentiation.
Topics: Blotting, Western; Breast Neoplasms; Butyrates; Butyric Acid; Cell Differentiation; Epithelial Cells; Fluorescent Antibody Technique; Hemin; Humans; In Vitro Techniques; Keratins; Leukemia, Erythroblastic, Acute; Membrane Glycoproteins; Mucin-1; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Differential regulation of gene expression by estrogen in estrogen growth-independent and -dependent MCF-7 human breast cancer cell sublines.
Topics: 1-Methyl-3-isobutylxanthine; Breast Neoplasms; Cell Line, Transformed; Clone Cells; Down-Regulation; Epidermal Growth Factor; Estradiol; Female; Gene Expression Regulation; Humans; Polyunsaturated Alkamides; Receptors, Cell Surface; Receptors, Estradiol; Receptors, Progesterone; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic | 1991 |
Differential effects of bryostatin 1 and phorbol ester on human breast cancer cell lines.
Topics: Breast Neoplasms; Bryostatins; Cell Division; Cell Membrane; Dose-Response Relationship, Drug; Enzyme Induction; Humans; Isoenzymes; Lactones; Macrolides; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Inhibition of estrogen receptor activity by the tumor promoter 12-O-tetradeconylphorbol-13-acetate: a molecular analysis.
Topics: Base Sequence; Blotting, Northern; Breast Neoplasms; Cell Division; DNA, Neoplasm; Down-Regulation; Estradiol; Female; HeLa Cells; Humans; Molecular Sequence Data; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Estrogen; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 1991 |
Decreased adherence of interleukin 6-treated breast carcinoma cells can lead to separation from neighbors after mitosis.
Topics: Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cell Adhesion; Cell Division; Cell Movement; DNA; Fluorouracil; Humans; Interleukin-6; Mitosis; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1991 |
Amphiregulin-associated protein: complete amino acid sequence of a protein produced by the 12-0-tetradecanoylphorbol-13-acetate-treated human breast adenocarcinoma cell line MCF-7.
Topics: Adenocarcinoma; Amino Acid Sequence; Animals; Breast Neoplasms; Carrier Proteins; Cell Line; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Female; Humans; Midkine; Molecular Sequence Data; Molecular Weight; Nerve Growth Factors; Protein Biosynthesis; Protein Conformation; Proteins; Sequence Homology, Nucleic Acid; Tetradecanoylphorbol Acetate | 1991 |
Unregulated expression of c-Jun or c-Fos proteins but not Jun D inhibits oestrogen receptor activity in human breast cancer derived cells.
Topics: Base Sequence; Blotting, Western; Breast Neoplasms; DNA-Binding Proteins; Estrogens; Fluorescent Antibody Technique; Gene Expression Regulation; Humans; Molecular Sequence Data; Plasmids; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Estrogen; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 1991 |
Phorbol ester and bryostatin effects on growth and the expression of oestrogen responsive and TGF-beta 1 genes in breast tumour cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Bryostatins; Cell Division; Culture Media; Estradiol; Gene Expression Regulation, Neoplastic; Lactones; Macrolides; Neoplasm Proteins; Proteins; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Thymidine; Transforming Growth Factor beta; Trefoil Factor-1; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1991 |
Transcriptional regulation of the human transforming growth factor-alpha gene.
Topics: Base Sequence; Breast Neoplasms; Dexamethasone; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Humans; In Vitro Techniques; Luciferases; Molecular Sequence Data; Sequence Homology, Nucleic Acid; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Transforming Growth Factor alpha; Tretinoin; Triiodothyronine; Tumor Cells, Cultured | 1991 |
Oestrogen directly stimulates growth factor signal transduction pathways in human breast cancer cells.
Topics: Blotting, Northern; Breast Neoplasms; Chloramphenicol O-Acetyltransferase; DNA, Neoplasm; Estrogens; Female; Humans; Proto-Oncogene Mas; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Neoplasm; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1991 |
Differentiation of cultured human breast cancer cells (AU-565 and MCF-7) associated with loss of cell surface HER-2/neu antigen.
Topics: Blotting, Southern; Breast Neoplasms; Cell Differentiation; Cell Division; Cell Membrane; Cell Nucleus; Cytoplasm; Genes; Humans; Mycophenolic Acid; Proto-Oncogene Proteins; Receptor, ErbB-2; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1990 |
Down-regulation of messenger ribonucleic acid and protein levels for estrogen receptors by phorbol ester and calcium in MCF-7 cells.
Topics: Breast Neoplasms; Calcimycin; Calcium; Down-Regulation; Estradiol; Humans; Kinetics; Receptors, Estrogen; Receptors, Progesterone; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
A 23-pS Ca2(+)-activated K+ channel in MCF-7 human breast carcinoma cells: an apparent correlation of channel incidence with the rate of cell proliferation.
Topics: Apamin; Breast Neoplasms; Calcium; Cell Division; Electric Conductivity; Epithelium; Humans; Potassium; Potassium Channels; Quinidine; Rubidium; Tamoxifen; Tetradecanoylphorbol Acetate; Tetraethylammonium Compounds; Tumor Cells, Cultured | 1991 |
Regulation of antitrypsin and antichymotrypsin synthesis by MCF-7 breast cancer cell sublines.
Topics: alpha 1-Antichymotrypsin; alpha 1-Antitrypsin; Blotting, Western; Breast Neoplasms; Chymotrypsin; Estradiol; Humans; Immunosorbent Techniques; Kinetics; Nucleic Acid Hybridization; Tetradecanoylphorbol Acetate; Transcription, Genetic; Trypsin; Tumor Cells, Cultured | 1990 |
Effects of differentiation-inducing agents on maturation of human MCF-7 breast cancer cells.
Topics: Acetamides; Antigens, Neoplasm; Breast Neoplasms; Butyrates; Butyric Acid; Cell Differentiation; Cell Division; Colforsin; Dimethylformamide; Fluorescent Antibody Technique; Humans; Membrane Glycoproteins; Mucin-1; Receptors, Estrogen; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1990 |
Protein kinase C subspecies in estrogen receptor-positive and -negative human breast cancer cell lines.
Topics: Biomarkers, Tumor; Breast Neoplasms; Calcium; Cell Line; Chromatography, Ion Exchange; Enzyme Activation; Female; Humans; Isoenzymes; Kinetics; Protein Kinase C; Receptors, Estrogen; Subcellular Fractions; Tetradecanoylphorbol Acetate | 1990 |
Modulation of the estrogen receptor structure, evidence of a heterogeneity.
Topics: Breast Neoplasms; Endopeptidases; Humans; Intracellular Fluid; Molecular Weight; Receptors, Estrogen; Sodium Dodecyl Sulfate; Tamoxifen; Tetradecanoylphorbol Acetate; Tritium; Tumor Cells, Cultured | 1990 |
Estradiol increases phosphorylation of the 90 kDa heat shock protein not associated with estradiol receptor in MCF-7 cells in culture.
Topics: Blotting, Western; Breast Neoplasms; Calcimycin; Colforsin; Estradiol; Heat-Shock Proteins; Humans; Phosphorylation; Receptors, Estrogen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Transforming growth factor beta (TGF-beta) reverses phorbol diester resistance of a breast adenocarcinoma (MCF-7) subline.
Topics: Adenocarcinoma; Breast Neoplasms; Cell Division; Humans; In Vitro Techniques; Neoplasm Proteins; Phosphoproteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tumor Cells, Cultured | 1990 |
Transcriptional regulation of DF3 gene expression in human MCF-7 breast carcinoma cells.
Topics: Antigens, Neoplasm; Blotting, Northern; Breast Neoplasms; Cycloheximide; Dactinomycin; Gene Expression Regulation; Glycoproteins; Humans; Molecular Weight; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1990 |
The respective 27 kDa and 28 kDa protein kinase C substrates in vascular endothelial and MCF-7 cells are most probably heat shock proteins.
Topics: Breast Neoplasms; Endothelium, Vascular; Heat-Shock Proteins; Humans; Molecular Weight; Phosphorylation; Protein Kinase C; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Differential effects of phorbol ester on epidermal growth factor receptors in estrogen receptor-positive and -negative breast cancer cell lines.
Topics: Breast Neoplasms; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Cycle; Cell Division; Cell Line; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Kinetics; Protein Kinase C; Receptors, Drug; Receptors, Estrogen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Opposite effects of tamoxifen on in vitro protein kinase C activity and endogenous protein phosphorylation in intact MCF-7 cells.
Topics: Breast Neoplasms; Estradiol; Female; Humans; Molecular Weight; Phosphorylation; Protein Kinase C; Proteins; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Effects of maturational agents on expression and secretion of two partially characterized high molecular weight milk-related glycoproteins in MCF-7 breast carcinoma cells.
Topics: Antibodies, Monoclonal; Antigens, Neoplasm; Breast Neoplasms; Cell Differentiation; Cell Line; Cross Reactions; Cytarabine; Female; Glycoproteins; Humans; Methionine; Milk Proteins; Molecular Weight; Neuraminidase; Protein Biosynthesis; RNA; Tetradecanoylphorbol Acetate | 1986 |
The 5' flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein.
Topics: Base Sequence; Breast Neoplasms; DNA-Binding Proteins; DNA, Neoplasm; Enhancer Elements, Genetic; Epidermal Growth Factor; Estrogens; Female; Gene Expression Regulation; Humans; Molecular Sequence Data; Neoplasm Proteins; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins p21(ras); RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transcription Factors; Trefoil Factor-1; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1989 |
Phorbol ester or epidermal growth factor (EGF) stimulates the concurrent accumulation of mRNA for the EGF receptor and its ligand transforming growth factor-alpha in a breast cancer cell line.
Topics: Antibodies, Monoclonal; Antigen-Antibody Reactions; beta-N-Acetylhexosaminidases; Breast Neoplasms; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Hexosaminidase A; Humans; Precipitin Tests; Protein Kinase C; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tumor Cells, Cultured | 1989 |
Protein kinase-C-induced down-regulation of calcitonin receptors and calcitonin-activated adenylate cyclase in T47D and BEN cells.
Topics: Adenylyl Cyclases; Breast Neoplasms; Calcitonin; Cell Line; Colforsin; Dinitrophenols; Down-Regulation; Enzyme Activation; Female; Humans; Kinetics; Lung Neoplasms; Protein Kinase C; Receptors, Calcitonin; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Regulation of cathepsin-D and pS2 gene expression by growth factors in MCF7 human breast cancer cells.
Topics: Breast Neoplasms; Cathepsin D; Cycloheximide; Dose-Response Relationship, Drug; Epidermal Growth Factor; Estradiol; Fibroblast Growth Factors; Gene Expression Regulation; Growth Substances; Humans; Insulin; Insulin-Like Growth Factor I; Neoplasm Proteins; Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Trefoil Factor-1; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1989 |
Modulation of estrogen receptor and epidermal growth factor receptor mRNAs by phorbol ester in MCF 7 breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Cell Line; ErbB Receptors; Gene Expression Regulation; Humans; Neoplasm Proteins; Receptors, Estrogen; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Ribosomal protein S6 kinase and PKC in human mammary tumor cells.
Topics: Alkaloids; Breast Neoplasms; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Estradiol; Growth Substances; Humans; Protein Kinase C; Protein Kinases; Ribosomal Protein S6 Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
A novel calcium signalling response in the breast cancer cell line MDA-468.
Topics: Aluminum; Aluminum Chloride; Aluminum Compounds; Breast Neoplasms; Calcium; Cell Line; Chlorides; Epidermal Growth Factor; Female; Fluorides; Humans; Kinetics; Pertussis Toxin; Protein Kinase C; Signal Transduction; Sodium Fluoride; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1989 |
Correlation between hormone dependency and the regulation of epidermal growth factor receptor by tumor promoters in human mammary carcinoma cells.
Topics: Breast Neoplasms; Cell Line; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Estrogens; Humans; Lyngbya Toxins; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Phorbols; Progesterone; Protein Kinase C; Receptors, Cell Surface; Receptors, Estrogen; Receptors, Progesterone; Tetradecanoylphorbol Acetate | 1986 |
Calmodulin antagonism and growth-inhibiting activity of triphenylethylene antiestrogens in MCF-7 human breast cancer cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Breast Neoplasms; Calmodulin; Cell Division; Cell Line; Cyclic Nucleotide Phosphodiesterases, Type 1; Estrogen Antagonists; Female; Humans; Protein Kinase C; Stilbenes; Tamoxifen; Tetradecanoylphorbol Acetate | 1986 |
Effects of tumor promoters on growth and on cellular redistribution of phospholipid/Ca2+-dependent protein kinase in human breast cancer cells.
Topics: Breast Neoplasms; Carcinogens; Cell Compartmentation; Cell Cycle; Cytosol; Dose-Response Relationship, Drug; Female; Humans; Lyngbya Toxins; Membranes; Protein Kinase C; Receptors, Estrogen; Tetradecanoylphorbol Acetate | 1986 |
Influence of 12-O-tetradecanoylphorbol-13-acetate on proliferation and maturation of human breast carcinoma cells (MCF-7): relationship to cell cycle events.
Topics: Breast Neoplasms; Carcinoma; Cell Division; Cell Line; Estradiol; Female; Humans; Interphase; Levonorgestrel; Norgestrel; Tamoxifen; Tetradecanoylphorbol Acetate | 1987 |
Inhibition of MCF-7 cell growth by 12-O-tetradecanoylphorbol-13-acetate and 1,2-dioctanoyl-sn-glycerol: distinct effects on protein kinase C activity.
Topics: Breast Neoplasms; Cell Division; Diglycerides; Dose-Response Relationship, Drug; Female; Glycerides; Humans; Phosphorylation; Protein Kinase C; Proteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1988 |
Effects of steroid hormones and peptide growth factors on protooncogene c-fos expression in human breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Cell Line; Dexamethasone; DNA Replication; Epidermal Growth Factor; Estradiol; Female; Growth Substances; Humans; Kinetics; Peptides; Progesterone; Proto-Oncogenes; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transforming Growth Factors | 1988 |
1,2-Dioctanoyl-glycerol induces a discrete but transient translocation of protein kinase C as well as the inhibition of MCF-7 cell proliferation.
Topics: Breast Neoplasms; Cell Division; Cytosol; Diglycerides; Dose-Response Relationship, Drug; Female; Glycerides; Humans; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1988 |
Continuous synthesis of two protein-kinase-C-related proteins after down-regulation by phorbol esters.
Topics: Breast Neoplasms; Depression, Chemical; Enzyme Induction; Female; Humans; Membrane Proteins; Neoplasm Proteins; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1988 |
The 27,000 daltons stress proteins are phosphorylated by protein kinase C during the tumor promoter-mediated growth inhibition of human mammary carcinoma cells.
Topics: Breast Neoplasms; Cell Line; Cell Membrane; Cytosol; Electrophoresis, Polyacrylamide Gel; Female; Heat-Shock Proteins; Humans; Molecular Weight; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate | 1988 |
Enhanced phosphorylation of progesterone receptor by protein kinase C in human breast cancer cells.
Topics: Breast Neoplasms; Cell Line; Centrifugation, Density Gradient; Electrophoresis, Polyacrylamide Gel; Female; Humans; Molecular Weight; Phosphorylation; Protein Kinase C; Receptors, Progesterone; Tetradecanoylphorbol Acetate | 1988 |
Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7.
Topics: Adenocarcinoma; Amino Acid Sequence; Amphiregulin; Animals; Breast Neoplasms; Cell Division; Cell Line; DNA Replication; EGF Family of Proteins; Glycoproteins; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Molecular Sequence Data; Tetradecanoylphorbol Acetate | 1988 |
Phorbol esters inhibit the proliferation of MCF-7 cells. Possible implication of protein kinase C.
Topics: Breast Neoplasms; Cell Division; Cell Line; Dose-Response Relationship, Drug; Female; Humans; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Epidermal growth factor receptor synthesis is stimulated by phorbol ester and epidermal growth factor. Evidence for a common mechanism.
Topics: Breast Neoplasms; Cell Line; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Kinetics; Tetradecanoylphorbol Acetate | 1987 |
Activation by phorbol esters of protein kinase C in MCF-7 human breast cancer cells.
Topics: Breast Neoplasms; Cell Line; Chromatography, DEAE-Cellulose; Cytosol; Enzyme Activation; Female; Humans; Phorbols; Phosphorylation; Protein Kinase C; Proteins; Tetradecanoylphorbol Acetate | 1986 |
Differing patterns of cytotoxicity of the phorbol ester 12-O-tetradecanoylphorbol 13-acetate in various human cell strains.
Topics: Breast Neoplasms; Cell Line; Cell Survival; Female; Fibroblasts; Humans; Kinetics; Male; Melanoma; Osteosarcoma; Phorbols; Prostatic Neoplasms; Tetradecanoylphorbol Acetate | 1985 |