tetradecanoylphorbol acetate has been researched along with Aging in 183 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 45 (24.59) | 18.7374 |
| 1990's | 100 (54.64) | 18.2507 |
| 2000's | 30 (16.39) | 29.6817 |
| 2010's | 5 (2.73) | 24.3611 |
| 2020's | 3 (1.64) | 2.80 |
| Authors | Studies |
|---|---|
| Che, Y; Chen, L; Li, SJ; Lv, J; Pang, H; Qin, J; Wang, X; Xi, W; Zhao, Q; Zhao, S | 1 |
| Gao, M; Gong, G; Li, A; Liu, B; Qin, Y; Tian, X; Wei, S | 1 |
| Buendia-Roldan, I; Chavez-Galan, L; Machahua, C; Molina-Molina, M; Ocaña-Guzman, R; Pardo, A; Selman, M | 1 |
| Belsham, DD; Centeno, ML; Chalmers, JA; McFadden, SA; Menchella, JA | 1 |
| Besalduch, N; Garcia, N; Hurtado, E; Lanuza, MA; Nadal, L; Obis, T; Priego, M; Santafe, MM; Tomàs, J; Tomàs, M | 1 |
| Khanfer, R; Lord, JM; Phillips, AC | 1 |
| Adam, A; John, CM; Ramasamy, R; Sandrasaigaran, P; Tong, CK | 1 |
| Brunauer, R; Gassner, R; Grubeck-Loebenstein, B; Herndler-Brandstetter, D; Jenewein, B; Kloss, F; Landgraf, K; Laschober, GT; Lepperdinger, G; Parson, W; Tzankov, A | 1 |
| Liu, TC; Pu, HF | 1 |
| Foerster, J; Myśliwska, J; Myśliwski, A; Szmit, E; Trzonkowski, P | 1 |
| Boon, AC; Fouchier, RA; Fringuelli, E; Graus, YM; Iorio, AM; Osterhaus, AD; Rimmelzwaan, GF; Sintnicolaas, K | 1 |
| Mancuso, R; Molinari, B; O'Connor, S; Tasat, DR | 1 |
| Bellodi, C; Cossarizza, A; Ferraresi, R; Mussi, C; Nasi, M; Pinti, M; Salvioli, G; Troiano, L | 1 |
| Holm, TL; Hornum, L; Lundsgaard, D; Markholst, H | 1 |
| Basu, T; Drager, KL; Field, CJ; Goruk, S; Van Aerde, A | 1 |
| Lyberg, T; Stritesky Larssen, K | 1 |
| Braun, SJ; Marko, M; Parsons, DF; Wansor, KJ | 1 |
| Morita, T; Moroyama, T; Okamoto, T; Okuda, K; Takada, K; Yoshiga, K | 1 |
| Belman, S; Fennikoh, KB; Garte, SJ | 1 |
| Lehrer, RI; Sherman, MP | 1 |
| Boutwell, RK; Conrad, EA; Cope, FO; Staller, JM | 1 |
| Fürstenberger, G; Marks, F | 1 |
| Chui, DH; Chung, SW; Clarke, BJ; Patterson, M; Reicheld, SM; White, JS; Wong, PM | 1 |
| Peto, R; Shubik, P; Stenbäck, F | 3 |
| Adler, WH; Chrest, FJ; Nagel, JE | 1 |
| Buzby, JS; Cairo, MS; Chang, M; Lee, SM; Suen, Y | 1 |
| Hayakawa, H; Ide, K; Nakano, M; Sato, A; Uchiyama, H; Yagi, T | 1 |
| Bogoyevitch, MA; Clerk, A; Fuller, SJ; Lazou, A; Parker, PJ; Sugden, PH | 1 |
| Hallgren, HM; Jackola, DR | 1 |
| Collins, BJ; Cuttler, L; Szabo, M | 1 |
| Ben-Ari, Y; Roisin, MP; Tremblay, E | 1 |
| Antonaci, S; Jirillo, E; Polignano, A; Tortorella, C; Venezia, A | 1 |
| Bashore, TR; Friedman, E; Wang, HY | 1 |
| Chiyo, T; Hongo, S; Sato, T | 1 |
| Aizawa, T; Hashizume, K; Ishihara, F; Komatsu, M; Nishii, N; Sato, Y; Suzuki, N; Yamada, T | 1 |
| Borzì, RM; Cattini, L; Facchini, A; Grigolo, B; Mariani, E; Monaco, MC; Porstmann, T | 1 |
| Fujiwara, T; Hattori, K; Hirata, Y; Kobayashi, Y; Kojima, T | 1 |
| Badesch, DB; Dempsey, EC; Dobyns, EL; Stenmark, KR | 1 |
| Klein, DC; White, BH | 1 |
| Dokas, LA; Han, YF; Shaffer, LM | 1 |
| Cohen, HJ; Rao, KM; Smart, BA | 1 |
| Ciccarelli, R; Cuccurullo, F; Di Febbo, C; Porreca, E | 1 |
| Cotsarelis, G; Fryer, E; Lavker, RM; Margolis-Fryer, J; Ostead, M; Sun, TT; Tokarek, R; Wei, ZG; Wilson, C | 1 |
| Judkins, JH; Meyer, EM | 1 |
| Brown, JH; Brunton, LL; Hilal-Dandan, R; Pucéat, M; Strulovici, B | 1 |
| Barry, WH; Hirata, Y; Ikenouchi, H; Kohmoto, O; Momomura, S; Serizawa, T | 1 |
| Brock, MA; Chrest, F | 1 |
| Fraeyman, N; van Ermen, A | 2 |
| Chen, M; Liu, B; Whisler, RL; Wu, LC | 1 |
| Rybin, VO; Steinberg, SF | 1 |
| Marliss, EB; Wu, G | 1 |
| Antonaci, S; Jirillo, E; Ottolenghi, A; Pugliese, P; Tortorella, C | 1 |
| Clark, BF; Derventzi, A; Rattan, SI | 1 |
| Liu, TC; Pu, HF; Wang, PS | 1 |
| Chan, SO; Wong, SS; Yeung, DC | 1 |
| Alvarez, E; Conde, M; Machado, A; Santa Maria, C; Sobrino, F | 1 |
| Becker, BA; Matteri, RL | 1 |
| Barcellini, W; Borghi, MO; Carbonelli, V; Del Papa, N; Fain, C; Gambini, D; La Rosa, L; Meroni, PL; Minonzio, F; Piona, A | 1 |
| Ershler, W; Lu, XG; Meyer, KC; Peterson, K; Rosenthal, NS | 1 |
| Bagenstose, SE; Newhouse, YG; Whisler, RL | 1 |
| Björk, L; Böhme, J; Pilström, B | 1 |
| Banchelli, G; Ferrali, C; Ignesti, G; Pino, R; Pirisino, R; Raimondi, L | 1 |
| Chen, LC; De Luca, LM; Huynh, M; Jones, CS; Tarone, R | 1 |
| Lea, RW; Liu, RC; Sharp, PJ | 1 |
| Ponnappan, U; Trebilcock, GU | 1 |
| Bini, A; Constantin, D; Meletti, E; Moldeus, P; Monti, D; Tomasi, A | 1 |
| Arbogast, A; Laforge, T; Phelouzat, MA; Proust, JJ; Quadri, RA | 1 |
| Hirokawa, K; Nariuchi, H; Wu, J; Yee, ST; Zeng, YX | 1 |
| Brewer, G; Buzby, JS; Cairo, MS; DeMaria, CT; Lee, SM; Van Winkle, P | 1 |
| Boström, S; Eriksson, E; Risberg, B; Rydholm, H | 1 |
| Battaini, F; Fortino, I; Govoni, S; Pascale, A; Trabucchi, M; Wetsel, WC | 1 |
| Bambara, LM; Bellavite, P; Biasi, D; Caramaschi, P; Carletto, A; Dell'Agnola, C; Montesanti, F; Zavateri, G; Zeminian, S | 1 |
| Alvarez, E; Santa Maria, C | 1 |
| Hirokawa, K; Nariuchi, H; Tamura, T; Utsuyama, M; Wakikawa, A | 1 |
| Higuchi, H; Hiroki, M; Nagahata, H; Noda, H | 1 |
| Baum, M; Harkins, EW; Quigley, R; Sheu, JN | 1 |
| Carroll, JA; Matteri, RL | 1 |
| Field, CJ; McBurney, MI; Yoo, SS | 1 |
| Delacourt, C; Delclaux, C; Harf, A; L'Hour, J; Lafuma, C; Rouet-Benzineb, P | 1 |
| Carle, KW; Liu, B; Whisler, RL | 1 |
| Feighery, C; Hennessy, TP; Holland, J; Jackson, J; Mealy, K; O'Mahony, L | 1 |
| Matsuse, T; Ouchi, Y; Suzuki, M; Teramoto, S | 1 |
| Cassano, GB; Giannaccini, G; Lucacchini, A; Marazziti, D; Masala, I; Mazzoni, M; Palego, L; Rossi, A; Rotondo, A | 1 |
| Bañares, A; Fernández-Gutiérrez, B; Hernández-García, C; Jover, JA; Pérez-Blas, M; Regueiro, JR; Ribera, JM; Serra, JA; Vidán, MT | 1 |
| Carlson, DM; Tesfaigzi, J | 1 |
| Bañares, A; De Miguel, S; Fernández-Gutiérrez, B; Hernández-García, C; Jover, JA; Ribera, JM; Serra, JA; Vidán, MT | 1 |
| Ford, GA; Noble, JM; Thomas, TH | 1 |
| Delgado, F; Lopez-Gonzalez, MA; Lucas, M | 1 |
| Kim, K; Oh, SH | 1 |
| Miller, RA; Tamir, A | 1 |
| Cai, G; Friedman, E; Johnson, GP; Uryu, K; Zhen, X | 1 |
| Li, M; Sierra, F; Torres, C; Walter, R | 1 |
| Elder, AC; Finkelstein, J; Gelein, R; Johnston, C; Oberdörster, G | 1 |
| Cadet, N; Paquin, J | 1 |
| Kita, T; Matsunaga, Y; Sakata-Kaneko, S; Usui, T; Wakatsuki, Y | 1 |
| Duchossoy, Y; Khatib, AM; Messai, H; Mitrovic, DR; Panasyuk, A | 1 |
| Canipari, R; Galdieri, M | 1 |
| Fürstenberger, G; Heidt, M; Krieg, P; Marks, F; Vogel, S | 1 |
| Enjalbert, A; Gautron, JP; Rochdi, L; Théraulaz, L | 1 |
| Emerson, MD; McManus, JR; Miller, KG; Rand, JB | 1 |
| Bashore, TR; Friedman, E; Tran, ZV; Wang, HY | 1 |
| Barratt, ME; Blades, TJ; Forsey, RJ; Hu, HL; Parmar, P; Powell, JR | 1 |
| Chen , JK; Heckert, LL | 1 |
| Aviram, M; Kaplan, M | 1 |
| Corsini, E; Galli, CL; Lucchi, L; Marinovich, M; Racchi, M; Viviani, B | 1 |
| Battalora, MS; Bortner, CD; Cape, JE; Lee, BM; Morris, RJ; Spalding, JW; Szczesniak, CJ; Tennant, RW; Trempus, CS | 1 |
| Alhonen, L; Jänne, J; Parkkinen, JJ; Pietilä, M | 1 |
| Alvarez, E; Ruiz-Gutiérrez, V; Santa-María, C; Sobrino, F | 1 |
| Drossou, V; Farmakis, C; Gioulekas, E; Goutzioulis, M; Kremenopoulos, G; Roilides, E; Tsiouris, J | 1 |
| Eckert, A; Fröhlich, L; Maurer, K; Müller, WE; Schindowski, K | 1 |
| Ebihara, Y; Takayama, M; Tani, M | 1 |
| Alonso, I; Garcia, N; González, CM; Lanuza, MA; Nelson, PG; Santafé, M; Tomàs, J | 1 |
| Oja, SS; Saransaari, P | 1 |
| Strannegård, IL | 1 |
| Melchionne, SM; Smith, AC; Van Duuren, BL | 1 |
| Balmain, A; Goerttler, K; Sauerborn, R; Stöhr, M | 1 |
| Ahern, M; Beckman, I; Bradley, J; Dimopoulos, K; Xu, X | 1 |
| Gershon, D; Lavie, L; Weinreb, O | 1 |
| Blackman, MR; Maki, T; Miyamoto, A; Roth, GS | 1 |
| James, SR; Naylor, JR; Trejdosiewicz, LK | 1 |
| Horikoshi, T; Inoue, H; Inoue, K; Miyazawa, A; Umeda, M; Yanagisawa, K; Yoshioka, T | 1 |
| Doré, M; Neilsen, NR; Slauson, DO | 2 |
| Joseph, K; Kawanishi, H | 1 |
| Hara, H; Negoro, S | 1 |
| Gobran, LI; Griese, M; Rooney, SA | 1 |
| Taniguchi, N | 1 |
| Fujita, T; Maruyama, N | 1 |
| Kato, Y; Tanigawa, K; Tsuchiyama, S | 1 |
| Curran, JA; Gauthey, L; Huang, YP; Loreto, M; Michel, JP; Michel, M; Pechere, JC | 1 |
| Cappel, RE; Gilbert, HF; Kodari, E; Reiners, JJ | 1 |
| Brady, FO | 1 |
| Cunningham, RK; Zaleski, MB; Zhou, P | 1 |
| Bélisle, S; Bellabarba, D; Gallo-Payet, N; Lehoux, JG | 1 |
| Thoman, ML | 1 |
| Cao, XM; Glenn, W; Monroe, JG; Sukhatme, VP; Yellen, AJ | 1 |
| Besemfelder, E; Fürstenberger, G; Hagedorn, H; Jacobi, T; Lehmann, WD; Marks, F; Stephan, M | 1 |
| Ghoneum, M; Gollapudi, S; Suzuki, K | 1 |
| Balduini, W; Costa, LG | 1 |
| Hess, ML; Kukreja, RC; Matin, S; Scott, RB; Wood, HE | 1 |
| Hertogh-Huijbregts, A; Nagelkerken, L; Rozing, J; Vissinga, C | 1 |
| Ferguson, F; Garman, C; Kariv, I; Sharlow, E | 1 |
| Friedman, E; Johnson, MD; Wang, HY | 1 |
| de Vries, JE; Pastorelli, G; Pène, J; Peronne, C; Roncarolo, MG; Rousset, F; Tovo, PA | 1 |
| Dunlop, M; Metz, SA | 1 |
| Cinader, B; Kubo, M | 2 |
| Balazovich, KJ; Boxer, LA; Indelicato, SR; Lipschitz, DA; Udupa, KB | 1 |
| Aoike, A; Awata, N; Azuma, J; Deguchi, Y; Hara, H; Hosokawa, T; Ling, J; Negoro, S; Nishio, S; Tanaka, T | 1 |
| O'Keefe, EJ; Petersen, MJ; Stricklin, GP; Woodley, DT | 1 |
| Rowe, JW; Wang, SY | 1 |
| Friedman, E; Wang, HY | 1 |
| Adler, WH; Chopra, RK; Holbrook, NJ; McCoy, MT; Nagel, JE; Powers, DC; Schneider, EL | 1 |
| Chu, SH; Ozaki, CK; Walker, WA | 1 |
| Adler, WH; Chopra, RK; Holbrook, NJ; McCoy, MT; Nagel, JE; Powers, DC | 1 |
| Barcellini, W; Borghi, MO; Ferraro, G; Meroni, PL; Vismara, A | 1 |
| Farmer, KJ; Sohal, RS | 1 |
| Chandler, LJ; Crews, FT | 1 |
| Lerner, A; Miller, RA; Yamada, T | 1 |
| Fujiwara, H; Hamaoka, T; Kiyotaki, C; Kosaka, H; Mizushima, Y; Ogata, M; Saitoh, M; Tatsumi, Y | 1 |
| Coffman, FD; Cohen, S; Fresa, KL; Hameed, MR | 1 |
| Dettmer, D; Hermsdorf, T; Hofmann, E; Lange, R | 1 |
| Coligan, JE; Kehn, PJ; Koning, F; Pereira, GM; Shevach, EM; Stingl, G; Yokoyama, WM | 1 |
| Fóris, G; Fülöp, T; Nagy, JT; Varga, Z | 1 |
| Butturini, U; Ceda, GP; Hoffman, AR; Valenti, G | 1 |
| Pryor, WA | 1 |
| Fujita, T; Katakami, Y; Koizumi, T; Matsui, T; Nakagawa, T; Nakao, Y | 1 |
| Buchholz, MA; Filburn, CR; Harrison, SA; Nordin, AA; Proust, JJ | 1 |
| Koizumi, T | 1 |
| Adler, WH; Chopra, RK; Chrest, FJ; Nagel, JE | 1 |
| Deguchi, Y; Hara, H; Kishimoto, S; Negoro, S; Nishio, S | 1 |
| Miller, RA | 1 |
| Fauchier, C; Jouquan, J; Pennec, Y; Youinou, P | 1 |
| Hayashi, I; Hayashi, M; Nagashima, Y; Nakano, T; Oh-Ishi, S; Utsunomiya, I; Yamaki, K; Yamasu, A | 1 |
| Rao, KM | 1 |
| Devor, D; Quander, R; Spangler, EF; Ward, JM; Wenk, ML | 1 |
| Carter, TH; Zelinsky-Papez, K; Zimmerman, JA | 1 |
| Ebbesen, P | 1 |
| Bianco, NE; Kondracki, E; Machado, I; Rivas, AJ | 1 |
| Arranto, A; Stenbäck, F | 1 |
3 review(s) available for tetradecanoylphorbol acetate and Aging
| Article | Year |
|---|---|
Expression, regulation, and function of the SPR family of proteins. A review.
Topics: Aging; Amino Acid Sequence; Animals; Calcium; Cell Count; Cell Division; CHO Cells; Consensus Sequence; Cornified Envelope Proline-Rich Proteins; Cricetinae; Cytokines; Digestive System; Epidermis; Gene Expression Regulation, Neoplastic; Humans; Intermediate Filament Proteins; Lung Neoplasms; Membrane Proteins; Molecular Sequence Data; Multigene Family; Neoplasms, Squamous Cell; Proteins; Respiratory System; Retinoids; Sequence Homology, Amino Acid; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1999 |
Clinical significances of superoxide dismutases: changes in aging, diabetes, ischemia, and cancer.
Topics: Aging; Diabetes Mellitus; Female; Humans; Ischemia; Male; Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1992 |
Oxy-radicals and related species: their formation, lifetimes, and reactions.
Topics: Aging; Air Pollutants; Animals; Catalase; Enzymes; Fatty Acids, Unsaturated; Free Radicals; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Longevity; Lung; Nitrogen Oxides; Oxidation-Reduction; Oxygen; Proteins; Smoking; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1986 |
180 other study(ies) available for tetradecanoylphorbol acetate and Aging
| Article | Year |
|---|---|
Loss of the voltage-gated proton channel Hv1 decreases insulin secretion and leads to hyperglycemia and glucose intolerance in mice.
Topics: Aging; Animals; Calcium; Calcium Signaling; Cell Size; Cytoplasmic Granules; Cytosol; Diabetes Mellitus, Experimental; Down-Regulation; Gene Deletion; Glucose; Glucose Intolerance; Hydrogen-Ion Concentration; Hyperglycemia; Insulin; Insulin Secretion; Insulin-Secreting Cells; Ion Channels; Membrane Potentials; Mice, Inbred C57BL; Mice, Knockout; Tetradecanoylphorbol Acetate | 2020 |
Mitoflash generated at the Qo site of mitochondrial Complex III.
Topics: Adenosine Triphosphate; Aging; Animals; Antioxidants; Cell Membrane Permeability; Electron Transport; Electron Transport Complex III; Electron Transport Complex IV; Mice; Mitochondria; Myocytes, Cardiac; Rats, Sprague-Dawley; Succinic Acid; Superoxides; Tetradecanoylphorbol Acetate | 2021 |
CD4+T cells in ageing-associated interstitial lung abnormalities show evidence of pro-inflammatory phenotypic and functional profile.
Topics: Aged; Aging; Case-Control Studies; CD4-Positive T-Lymphocytes; Cell Proliferation; Cytokines; Female; Humans; Lung Diseases, Interstitial; Male; Middle Aged; Phenotype; Tetradecanoylphorbol Acetate | 2021 |
Glucose responsiveness in a novel adult-derived GnRH cell line, mHypoA-GnRH/GFP: involvement of AMP-activated protein kinase.
Topics: Aging; AMP-Activated Protein Kinases; Animals; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; Glucose; Gonadotropin-Releasing Hormone; Green Fluorescent Proteins; Mice; Models, Biological; Neurons; Nitric Oxide; Peptides; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; RNA, Messenger; Second Messenger Systems; Signal Transduction; Tetradecanoylphorbol Acetate | 2013 |
The novel protein kinase C epsilon isoform at the adult neuromuscular synapse: location, regulation by synaptic activity-dependent muscle contraction through TrkB signaling and coupling to ACh release.
Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Electrophysiological Phenomena; Intracellular Signaling Peptides and Proteins; Isoenzymes; Male; Membrane Proteins; Models, Biological; Muscle Contraction; Muscle, Skeletal; Myristoylated Alanine-Rich C Kinase Substrate; Neuromuscular Junction; Phosphorylation; Protein Kinase C-epsilon; Rats, Sprague-Dawley; Receptor, trkB; Signal Transduction; Synapses; Tetradecanoylphorbol Acetate | 2015 |
Neutrophil function and cortisol:DHEAS ratio in bereaved older adults.
Topics: Aged; Aging; Anxiety; Bereavement; Case-Control Studies; Dehydroepiandrosterone Sulfate; Depression; Escherichia coli; Female; Humans; Hydrocortisone; Male; Neutrophils; Phagocytosis; Respiratory Burst; Severity of Illness Index; Stress, Psychological; Superoxides; Surveys and Questionnaires; Tetradecanoylphorbol Acetate | 2011 |
Immunomodulatory activity of polyphenols derived from Cassia auriculata flowers in aged rats.
Topics: Aging; Animals; B-Lymphocytes; Cassia; Cell Proliferation; Female; Flowers; Immunologic Factors; In Vitro Techniques; Lipopolysaccharides; Lymphocyte Activation; Neutrophils; Polyphenols; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; T-Lymphocyte Subsets; Tetradecanoylphorbol Acetate | 2011 |
The impact of aging on memory T cell phenotype and function in the human bone marrow.
Topics: Adult; Aged; Aging; Antigens, Differentiation, T-Lymphocyte; Bone Marrow; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Cytokines; Female; Gene Rearrangement, T-Lymphocyte; Humans; Immunologic Memory; Ionomycin; Lymphocyte Count; Male; Middle Aged; T-Lymphocyte Subsets; Tetradecanoylphorbol Acetate | 2012 |
Differential involvement of protein kinase C in basal versus acetylcholine-regulated prolactin secretion in rat anterior pituitary cells during aging.
Topics: Acetylcholine; Aging; Angiotensin II; Animals; Dopamine; Female; Pituitary Gland, Anterior; Prolactin; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Vasoactive Intestinal Peptide | 2002 |
Ex vivo apoptotic potential of peripheral blood mononuclear cells of the elderly human subject.
Topics: Adult; Aged; Aged, 80 and over; Aging; Annexin A5; Antigens, Viral; Apoptosis; Cell Cycle; Cells, Cultured; DNA Fragmentation; Humans; Immune System; Influenza Vaccines; Leukocytes, Mononuclear; Lymphocyte Activation; Propidium; Tetradecanoylphorbol Acetate | 2002 |
Influenza A virus specific T cell immunity in humans during aging.
Topics: Adolescent; Adult; Aged; Aging; CD8-Positive T-Lymphocytes; Cohort Studies; Female; Humans; Influenza A virus; Interferon-gamma; Interleukin-4; Ionomycin; Leukocytes, Mononuclear; Lymphocyte Activation; Lymphocyte Count; Male; Middle Aged; T-Lymphocytes; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate | 2002 |
Age-dependent change in reactive oxygen species and nitric oxide generation by rat alveolar macrophages.
Topics: Aging; Animals; Cells, Cultured; Escherichia coli; Lipopolysaccharides; Macrophages, Alveolar; Male; Nitric Oxide; Phagocytosis; Rats; Rats, Wistar; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Time Factors | 2003 |
Balanced regulation of mRNA production for Fas and Fas ligand in lymphocytes from centenarians: how the immune system starts its second century.
Topics: Adult; Aged; Aged, 80 and over; Aging; Apoptosis; Enzyme-Linked Immunosorbent Assay; Fas Ligand Protein; fas Receptor; Female; Flow Cytometry; Gene Expression Regulation; Humans; Ionomycin; Longevity; Lymphocytes; Male; Membrane Glycoproteins; Membrane Proteins; Middle Aged; Protein Isoforms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Solubility; Tetradecanoylphorbol Acetate | 2004 |
In vivo control of diabetogenic T-cells by regulatory CD4+CD25+ T-cells expressing Foxp3.
Topics: Adoptive Transfer; Aging; Animals; CD4 Antigens; Diabetes Mellitus, Type 1; DNA-Binding Proteins; Forkhead Transcription Factors; Gene Expression; Ionomycin; Lymphocyte Activation; Prediabetic State; Rats; Receptors, Interleukin-2; T-Lymphocyte Subsets; Tetradecanoylphorbol Acetate; Transcription Factors | 2005 |
Dietary folate improves age-related decreases in lymphocyte function.
Topics: Aging; Animals; Body Weight; Cell Proliferation; Cytokines; Dietary Supplements; Eating; Folic Acid; Ionomycin; Lymph Nodes; Male; Rats; Rats, Inbred F344; Spleen; T-Lymphocytes; Tetradecanoylphorbol Acetate; Vitamin B 12 | 2006 |
Oxidative status--age- and circadian variations?--a study in leukocytes/plasma.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antioxidants; Carcinogens; Circadian Rhythm; Female; Flow Cytometry; Granulocytes; Humans; Infant, Newborn; Male; Middle Aged; Monocytes; Oxidative Stress; Reactive Oxygen Species; Tetradecanoylphorbol Acetate | 2006 |
"Dark cells" in normal, hyperplastic, and promoter-treated mouse epidermis studied by conventional and high-voltage electron microscopy.
Topics: Aging; Animals; Epidermal Cells; Epidermis; Female; Hyperplasia; Mice; Microscopy, Electron; Neoplasms, Experimental; Phorbols; Pregnancy; Staining and Labeling; Tetradecanoylphorbol Acetate | 1983 |
Differentiation of cultured epidermal keratinocytes related to sterol metabolism and its retardation by chemical carcinogens.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetates; Acetic Acid; Aging; Animals; Carcinogens; Cell Differentiation; Cholesterol; Epidermal Cells; Epidermis; Keratins; Mice; Mice, Inbred BALB C; Sterols; Tetradecanoylphorbol Acetate | 1984 |
Comparison of the effects of age and phorbol myristate acetate on the beta-adrenergic system in mouse epidermis.
Topics: Aging; Animals; Cyclic AMP; Epidermis; Female; Isoproterenol; Mice; Mice, Inbred ICR; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Superoxide generation by neonatal and adult rabbit alveolar macrophages.
Topics: Aging; Animals; Animals, Newborn; Bordetella Infections; Cytochalasins; Female; Kinetics; Macrophages; Male; Pentobarbital; Rabbits; Superoxides; Tetradecanoylphorbol Acetate | 1984 |
Induction of mouse brain ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate is independent of TPA receptor concentration.
Topics: Aging; Animals; Brain; Caenorhabditis elegans Proteins; Carrier Proteins; Enzyme Induction; Mice; Mice, Inbred ICR; Ornithine Decarboxylase; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Substrate Specificity; Tetradecanoylphorbol Acetate | 1984 |
Stages of tumour promotion in skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Aging; Animals; Animals, Newborn; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Hyperplasia; Mice; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Wounds and Injuries | 1984 |
Adult hemoglobins are synthesized in murine fetal hepatic erythropoietic cells.
Topics: Aging; Animals; Cells, Cultured; Erythroblasts; Erythropoiesis; Erythropoietin; Female; Fetus; Hematopoietic Stem Cells; Hemoglobins; Isoelectric Focusing; Liver; Male; Mice; Mice, Mutant Strains; Pregnancy; Rabbits; Tetradecanoylphorbol Acetate | 1983 |
Initiation and promotion at different ages and doses in 2200 mice. I. Methods, and the apparent persistence of initiated cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Dose-Response Relationship, Drug; Drug Synergism; Female; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Initiation and promotion at different ages and doses in 2200 mice. II. Decrease in promotion by TPA with ageing.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Dose-Response Relationship, Drug; Drug Synergism; Female; Mice; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Initiation and promotion at different ages and doses in 2200 mice. III. Linear extrapolation from high doses may underestimate low-dose tumour risks.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Dose-Response Relationship, Drug; Drug Synergism; Female; Mice; Neoplasms, Experimental; Risk; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Mitogenic activity of 12-O-tetradecanoyl phorbol-13-acetate on peripheral blood lymphocytes from young and aged adults.
Topics: Adult; Aged; Aging; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Female; Humans; Indomethacin; Lymphocyte Activation; Lymphocytes; Male; Middle Aged; Mitogens; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1982 |
Regulation of interleukin-11 protein and mRNA expression in neonatal and adult fibroblasts and endothelial cells.
Topics: Adult; Aging; Aorta; Base Sequence; Cell Differentiation; Cells, Cultured; Endothelium, Vascular; Fetal Blood; Fibroblasts; Gene Expression Regulation; Hematopoietic Cell Growth Factors; Humans; Infant, Newborn; Interleukin-1; Interleukin-11; Interleukin-3; Interleukin-6; Male; Megakaryocytes; Molecular Sequence Data; Polymerase Chain Reaction; Recombinant Fusion Proteins; RNA, Messenger; Stem Cell Factor; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 1994 |
Superoxide generation by alveolar macrophages from aged rats: improvement by in vitro treatment with IFN-gamma.
Topics: Aging; Animals; Body Weight; Bronchoalveolar Lavage Fluid; Cells, Cultured; Interferon-gamma; Lung; Macrophages, Alveolar; Male; Organ Size; Rats; Rats, Sprague-Dawley; Spleen; Superoxides; Tetradecanoylphorbol Acetate | 1995 |
Expression of protein kinase C isoforms during cardiac ventricular development.
Topics: Aging; Amino Acid Sequence; Animals; Animals, Newborn; Cells, Cultured; Chemical Fractionation; Fetus; Heart; Humans; Isoenzymes; Male; Molecular Sequence Data; Myocardium; Protein Kinase C; Rats; Rats, Sprague-Dawley; Solubility; Tetradecanoylphorbol Acetate | 1995 |
Diminished cell-cell binding by lymphocytes from healthy, elderly humans: evidence for altered activation of LFA-1 function with age.
Topics: Adult; Aged; Aging; Antimetabolites; Blood Donors; Cell Adhesion; Humans; Ionomycin; Kinetics; Lymphocyte Function-Associated Antigen-1; Lymphocytes; Reference Values; Tetradecanoylphorbol Acetate | 1995 |
Ontogeny of the GH response to phorbol ester and phospholipase C in rat pituitary cells.
Topics: Aging; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Growth Hormone; Male; Pituitary Gland; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Somatostatin; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1995 |
Different GABAB-mediated effects on protein kinase C activity and immunoreactivity in neonatal and adult rat hippocampal slices.
Topics: Aging; Animals; Baclofen; Hippocampus; Immunoblotting; In Vitro Techniques; Male; Neurons; Protein Kinase C; Rats; Rats, Wistar; Receptors, GABA-B; Tetradecanoylphorbol Acetate; Tissue Distribution | 1995 |
Age-associated changes of neutrophil responsiveness in a human healthy elderly population.
Topics: Adult; Aged; Aged, 80 and over; Aging; Chemotaxis, Leukocyte; Cytotoxicity, Immunologic; Female; Humans; Leukocyte Count; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phagocytosis; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate | 1994 |
Exercise reduces age-dependent decrease in platelet protein kinase C activity and translocation.
Topics: Adult; Aged; Aging; Blood Platelets; Cell Membrane; Cytosol; Exercise; Humans; Male; Middle Aged; Oxygen Consumption; Phosphorylation; Physical Fitness; Protein Kinase C; Serotonin; Tetradecanoylphorbol Acetate; Thrombin | 1995 |
Induction of asparagine synthetase by follicle-stimulating hormone in primary cultures of rat Sertoli cells.
Topics: Aging; Animals; Aspartate-Ammonia Ligase; Blotting, Northern; Blotting, Western; Brain; Bucladesine; Cells, Cultured; Culture Techniques; Dinoprostone; Enzyme Induction; Follicle Stimulating Hormone; Insulin; Kinetics; Liver; Male; Rats; Rats, Wistar; RNA, Messenger; Sertoli Cells; Testis; Testosterone; Tetradecanoylphorbol Acetate; Time Factors | 1994 |
Insulin secretion by the pancreatic beta cell of aged rats.
Topics: Aging; Animals; Colforsin; Dose-Response Relationship, Drug; Glucose; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Nifedipine; Potassium; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1994 |
Intracellular Cu/Zn superoxide dismutase levels in T and non-T cells from normal aged subjects.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antibodies, Monoclonal; CD3 Complex; Concanavalin A; Female; Humans; Immunoenzyme Techniques; Lymphocyte Subsets; Male; Reference Values; Sensitivity and Specificity; Statistics as Topic; Superoxide Dismutase; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1994 |
Maturational changes in superoxide anion production of rabbit alveolar macrophages.
Topics: Aging; Animals; Cells, Cultured; Endothelins; Imidazoles; Luminescent Measurements; Macrophages, Alveolar; Male; N-Formylmethionine Leucyl-Phenylalanine; Pyrazines; Rabbits; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate | 1994 |
Enhanced growth capacity of neonatal pulmonary artery smooth muscle cells in vitro: dependence on cell size, time from birth, insulin-like growth factor I, and auto-activation of protein kinase C.
Topics: Aging; Animals; Animals, Newborn; Blood; Cattle; Cell Division; Cells, Cultured; Enzyme Activation; Flow Cytometry; Insulin-Like Growth Factor I; Muscle, Smooth, Vascular; Protein Kinase C; Pulmonary Artery; Subcellular Fractions; Tetradecanoylphorbol Acetate; Thymidine | 1994 |
Developmental appearance of pineal adrenergic-->guanosine 3',5'-monophosphate response is determined by a process down-stream from elevation of intracellular Ca2+: possible involvement of a diffusible factor.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adrenal Glands; Aging; Animals; Arachidonic Acid; Calcium; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Cytosol; Guanylate Cyclase; Isoproterenol; Kinetics; Mice; Norepinephrine; Organ Culture Techniques; Phospholipases A; Phospholipases A2; Pineal Gland; Potassium; Protein Kinases; Rats; Tetradecanoylphorbol Acetate | 1993 |
Phorbol ester- and glutamate-sensitive phosphorylation of hippocampal membrane proteins from adult and neonatal rats.
Topics: Aging; Animals; Animals, Newborn; Glutamates; Glutamic Acid; Hippocampus; Male; Membrane Proteins; Phosphorylation; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Tissue Distribution | 1993 |
Age-related increase in phorbol myristate acetate-induced lymphocyte adhesion to vascular endothelium.
Topics: Adult; Aged; Aging; Cell Adhesion; Cell Survival; Endothelium, Vascular; Humans; Lymphocytes; Middle Aged; Tetradecanoylphorbol Acetate | 1993 |
Protein kinase C pathway and proliferative responses of aged and young rat vascular smooth muscle cells.
Topics: Aging; Animals; Aorta; Cell Cycle; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Down-Regulation; Male; Muscle, Smooth, Vascular; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1993 |
Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles.
Topics: Aging; Animals; Cell Division; DNA; Hair; Mice; Mice, Inbred Strains; Mitosis; Skin; Tetradecanoylphorbol Acetate; Thymidine; Tretinoin | 1994 |
The development of age-related deficits in several presynaptic processes associated with brain [3H]acetylcholine release.
Topics: Acetylcholine; Aging; Animals; Brain; Calcimycin; Calcium; Cerebral Cortex; Chloramphenicol O-Acetyltransferase; In Vitro Techniques; Male; Presynaptic Terminals; Protein Kinase C; Rats; Rats, Inbred F344; Tetradecanoylphorbol Acetate; Veratridine; Visual Cortex | 1993 |
Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes.
Topics: Aging; Animals; Animals, Newborn; Blotting, Western; Carbachol; Cell Membrane; Cells, Cultured; Cytosol; Egtazic Acid; Gene Expression Regulation, Enzymologic; Genes, fos; Heart; Isoenzymes; Kinetics; Myocardium; Phosphoproteins; Phosphorylation; Propranolol; Protein Kinase C; Proto-Oncogene Proteins c-fos; Rats; Tetradecanoylphorbol Acetate | 1994 |
Variable effects of endothelin-1 on [Ca2+]i transients, pHi, and contraction in ventricular myocytes.
Topics: Aging; Angiotensin II; Animals; Animals, Newborn; Calcium; Cell Movement; Cells, Cultured; Chick Embryo; Endothelins; Heart Ventricles; Hydrogen-Ion Concentration; Intracellular Membranes; Myocardial Contraction; Myocardium; Rabbits; Rats; Tetradecanoylphorbol Acetate | 1993 |
Differential regulation of actin polymerization following activation of resting T lymphocytes from young and aged mice.
Topics: Actin Cytoskeleton; Actins; Aging; Animals; Cell Cycle; Cell Division; Cell Membrane; Cell Movement; Cells, Cultured; Concanavalin A; Cytochalasins; Cytoskeleton; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Polymers; Receptors, Interleukin-2; Resting Phase, Cell Cycle; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1993 |
Influence of aging on the beta- and glucagon-receptor-mediated glycogenolysis in rat hepatocytes.
Topics: Aging; Animals; Calcium; Egtazic Acid; Enzyme Activation; In Vitro Techniques; Liver; Liver Glycogen; Male; Nifedipine; Protein Kinase C; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Glucagon; Tetradecanoylphorbol Acetate; Verapamil | 1993 |
Reduced activation of transcriptional factor AP-1 among peripheral blood T cells from elderly humans after PHA stimulation: restorative effect of phorbol diesters.
Topics: Adult; Aged; Aged, 80 and over; Aging; Amino Acid Sequence; Female; Humans; Lymphocyte Activation; Male; Molecular Sequence Data; Nuclear Proteins; Phytohemagglutinins; Proto-Oncogene Proteins c-jun; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1993 |
Influence of aging on the alpha 1-receptor-mediated glycogenolysis in rat hepatocytes.
Topics: Aging; Animals; Calcium; Calcium Channel Blockers; Glucose; In Vitro Techniques; Insulin; Liver; Liver Glycogen; Male; Models, Biological; Protein Kinase C; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Tetradecanoylphorbol Acetate | 1994 |
Protein kinase C isoform expression and regulation in the developing rat heart.
Topics: Aging; Animals; Animals, Newborn; Calcium; Heart; Heart Conduction System; Heart Ventricles; Immunoblotting; Isoenzymes; Myocardium; Protein Kinase C; Rats; Rats, Wistar; Subcellular Fractions; Sympathetic Nervous System; Tetradecanoylphorbol Acetate | 1994 |
Enhanced glucose metabolism and respiratory burst in peritoneal macrophages from spontaneously diabetic BB rats.
Topics: Aging; Analysis of Variance; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Female; Glucose; Glycolysis; Hydrogen Peroxide; Ionomycin; Lactates; Macrophages; Pentose Phosphate Pathway; Prediabetic State; Pyruvates; Rats; Rats, Inbred BB; Superoxides; Tetradecanoylphorbol Acetate | 1993 |
Relationship between respiratory burst and adhesiveness capacity in elderly polymorphonuclear cells.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antibodies, Monoclonal; Cell Adhesion; Female; Humans; In Vitro Techniques; Integrins; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate | 1993 |
Phorbol ester PMA stimulates protein synthesis and increases the levels of active elongation factors EF-1 alpha and EF-2 in ageing human fibroblasts.
Topics: Aging; Dose-Response Relationship, Drug; Fibroblasts; Humans; Osmolar Concentration; Peptide Elongation Factor 1; Peptide Elongation Factor 2; Peptide Elongation Factors; Protein Biosynthesis; Tetradecanoylphorbol Acetate | 1993 |
Unimpaired postreceptor regulation of luteinizing hormone secretion by gonadotropin-releasing hormone and estrogen in aged rat anterior pituitary cells.
Topics: Aging; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Estradiol; Female; Gonadotropin-Releasing Hormone; Kinetics; Luteinizing Hormone; Ovariectomy; Pituitary Gland, Anterior; Rats; Rats, Sprague-Dawley; Receptors, LH; Tetradecanoylphorbol Acetate | 1993 |
Insulin induction of c-Ki-ras in rat liver and in cultured normal rat hepatocytes.
Topics: Aging; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Enzyme Activation; Gene Expression; Insulin; Liver; Protein Kinase C; Proto-Oncogene Proteins p21(ras); Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Decrease in free-radical production with age in rat peritoneal macrophages.
Topics: Aging; Animals; Biological Transport; Cells, Cultured; Female; Free Radicals; Glucose; Hydrogen Peroxide; Macrophages, Peritoneal; NADH, NADPH Oxidoreductases; NADP; NADPH Oxidases; Nitrites; Oxidation-Reduction; Pentose Phosphate Pathway; Rats; Rats, Wistar; Superoxides; Tetradecanoylphorbol Acetate | 1995 |
Lactotroph and somatotroph function in piglets reared in a constant hot environment.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acclimatization; Aging; Animals; Animals, Newborn; Cells, Cultured; Cold Temperature; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Hot Temperature; Male; Orchiectomy; Pituitary Gland, Anterior; Prolactin; Radioimmunoassay; Reproducibility of Results; Swine; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1996 |
[Effect of pidotimod on the function of the human immune system: in vitro and ex vivo study].
Topics: Adjuvants, Immunologic; Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Antibody Formation; Chemotaxis, Leukocyte; Humans; Immune System; Interferon-gamma; Interleukin-1; Interleukin-2; Interleukin-6; Lymphocyte Activation; Lymphocyte Subsets; Mitogens; Muromonab-CD3; Neutrophils; Phagocytosis; Phytohemagglutinins; Pyrrolidonecarboxylic Acid; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidines | 1993 |
Immune dysregulation in the aging human lung.
Topics: Adult; Aged; Aging; Albumins; Antigens, Surface; Bronchoalveolar Lavage Fluid; CD4-CD8 Ratio; Disease Susceptibility; Female; Humans; Immunoglobulin A; Immunoglobulin G; Interleukin-10; Interleukin-6; Lung; Lung Diseases; Male; Middle Aged; Neutrophils; Pneumonia; Superoxides; Tetradecanoylphorbol Acetate | 1996 |
Age-related reductions in the activation of mitogen-activated protein kinases p44mapk/ERK1 and p42mapk/ERK2 in human T cells stimulated via ligation of the T cell receptor complex.
Topics: Adult; Aged; Aged, 80 and over; Aging; Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Ethers, Cyclic; Female; Humans; Ionomycin; Ionophores; Isoenzymes; Lectins; Lymphocyte Activation; Male; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Muromonab-CD3; Okadaic Acid; Phosphorylation; Phytohemagglutinins; Protein Kinase C; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptor-CD3 Complex, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1996 |
Demonstration of a TH1 cytokine profile in the late phase of NOD insulitis.
Topics: Aging; Animals; Cells, Cultured; Cytokines; Diabetes Mellitus, Type 1; Female; Fluorescent Antibody Technique; Granulocyte-Macrophage Colony-Stimulating Factor; Interferon-gamma; Interleukin-1; Interleukin-10; Interleukin-2; Interleukin-4; Interleukin-6; Ionomycin; Islets of Langerhans; Mice; Mice, Inbred NOD; Microscopy, Fluorescence; Pancreatic Diseases; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha | 1995 |
Increased desensitization by picomolar phorbol ester of the endothelium-mediated effect of histamine in the perfused rat mesenteric bed.
Topics: Aging; Alkaloids; Animals; Carbachol; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Histamine; Male; Mesenteric Arteries; Norepinephrine; Parasympathomimetics; Perfusion; Protein Kinase C; Rats; Rats, Wistar; Receptors, Histamine H1; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents; Vasodilation | 1996 |
Dietary retinoic acid inhibits mouse skin carcinogenesis irrespective of age at initiation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Antineoplastic Agents; Carcinogens; Diet; Diterpenes; Female; Mice; Papilloma; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Tretinoin | 1996 |
Effect of age of donor on the responsiveness of dispersed and cultured chicken anterior pituitary cells to GnRH-I.
Topics: Aging; Animals; Cells, Cultured; Chickens; Female; Gonadotropin-Releasing Hormone; Kinetics; Luteinizing Hormone; Male; Oviposition; Pituitary Gland, Anterior; Protein Kinase C; Tetradecanoylphorbol Acetate | 1996 |
Evidence for lowered induction of nuclear factor kappa B in activated human T lymphocytes during aging.
Topics: Adult; Aged; Aged, 80 and over; Aging; Carcinogens; CD3 Complex; Female; Humans; Lymphocyte Activation; Male; NF-kappa B; Oligonucleotide Probes; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1996 |
Age-related differences in the metabolism of sulphite to sulphate and in the identification of sulphur trioxide radical in human polymorphonuclear leukocytes.
Topics: Aging; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Neutrophils; Oxidation-Reduction; Oxidoreductases Acting on Sulfur Group Donors; Oxygen Consumption; Spin Labels; Spin Trapping; Sulfates; Sulfites; Sulfur Oxides; Tetradecanoylphorbol Acetate | 1996 |
Excessive apoptosis of mature T lymphocytes is a characteristic feature of human immune senescence.
Topics: Adult; Aged; Aged, 80 and over; Aging; Apoptosis; CD3 Complex; Cell Division; Cells, Cultured; Cellular Senescence; DNA Fragmentation; Glutathione; Humans; Immune System; Interleukin-2; Intracellular Membranes; Ionomycin; Lymphocyte Activation; Proto-Oncogene Proteins c-bcl-2; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1996 |
Abnormality in the early signal transduction pathway is responsible for the impaired proliferative response and low K+ current in a T-cell clone by stimulation with anti-CD3 antibody.
Topics: Aging; Animals; Antibodies, Monoclonal; Calcium; CD3 Complex; Clone Cells; Ionomycin; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Potassium; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1996 |
Increased granulocyte-macrophage colony-stimulating factor mRNA instability in cord versus adult mononuclear cells is translation-dependent and associated with increased levels of A + U-rich element binding factor.
Topics: Adult; Aging; Cycloheximide; Fetal Blood; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Half-Life; Heterogeneous Nuclear Ribonucleoprotein D0; Heterogeneous-Nuclear Ribonucleoprotein D; Humans; Infant, Newborn; Leukocytes, Mononuclear; Phytohemagglutinins; Protein Biosynthesis; Protein Synthesis Inhibitors; Regulatory Sequences, Nucleic Acid; RNA-Binding Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate | 1996 |
Different fibrinolytic potentials between human umbilical vein endothelial cells and human adult vein endothelial cells.
Topics: Adult; Aging; Cells, Cultured; Endothelium, Vascular; Endotoxins; Fibrinolysis; Humans; Infant, Newborn; Plasminogen Activator Inhibitor 1; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator; Umbilical Veins; Veins | 1996 |
Functional impairment in protein kinase C by RACK1 (receptor for activated C kinase 1) deficiency in aged rat brain cortex.
Topics: Aging; Animals; Antibodies, Monoclonal; Biological Transport; Blotting, Western; Carcinogens; Cerebral Cortex; Isoenzymes; Male; Peptides; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-delta; Protein Kinase C-epsilon; Rats; Rats, Wistar; Receptors for Activated C Kinase; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1996 |
Neutrophil migration, oxidative metabolism, and adhesion in elderly and young subjects.
Topics: Adult; Aged; Aged, 80 and over; Aging; Cell Adhesion; Chemotaxis, Leukocyte; Female; Humans; Male; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1996 |
Influence of the age and sex on respiratory burst of human monocytes.
Topics: Adult; Aged; Aging; Female; Humans; Male; Middle Aged; Monocytes; NADPH Oxidases; Respiratory Burst; Sex Characteristics; Stimulation, Chemical; Superoxides; Tetradecanoylphorbol Acetate | 1996 |
Impairment of signal transduction in T cells from old mice.
Topics: Aging; Animals; Calcium; Clone Cells; Diglycerides; Inositol 1,4,5-Trisphosphate; Interleukin-2; Kinetics; Lymphocyte Activation; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Phosphatidylinositol 4,5-Diphosphate; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Antigen, T-Cell, alpha-beta; Signal Transduction; Spleen; T-Lymphocytes; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1997 |
Relationship between age-dependent changes of bovine neutrophil functions and their intracellular Ca2+ concentrations.
Topics: Aging; Animals; Calcium; Cattle; Cell Separation; Female; Flow Cytometry; Immunoglobulin G; Luminescent Measurements; Macrophage-1 Antigen; Neutrophils; Phagocytosis; Receptors, Fc; Tetradecanoylphorbol Acetate; Zymosan | 1997 |
Maturational changes in rabbit renal cortical phospholipase A2 activity.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aging; Animals; Animals, Newborn; Annexin A1; Cyclic AMP; Cytosol; Dexamethasone; In Vitro Techniques; Kidney Cortex; Microsomes; Parathyroid Hormone; Phospholipases A; Phospholipases A2; Rabbits; Signal Transduction; Tetradecanoylphorbol Acetate | 1997 |
Somatotroph function in the neonatal pig.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aging; Animals; Animals, Newborn; Base Sequence; Carrier Proteins; Cells, Cultured; DNA Primers; DNA, Complementary; Dose-Response Relationship, Drug; Gene Expression Regulation, Developmental; Growth Hormone; Growth Hormone-Releasing Hormone; Linear Models; Male; Membrane Proteins; Phospholipid Transfer Proteins; Pituitary Gland, Anterior; Polymerase Chain Reaction; Radioimmunoassay; Receptors, Neuropeptide; Receptors, Pituitary Hormone-Regulating Hormone; RNA, Messenger; Swine; Tetradecanoylphorbol Acetate | 1997 |
Glutamine supplementation maintains intramuscular glutamine concentrations and normalizes lymphocyte function in infected early weaned pigs.
Topics: Aging; Amino Acids; Animals; Body Temperature; Carcinogens; Cell Division; Concanavalin A; Diet; Dietary Supplements; DNA; Escherichia coli; Escherichia coli Infections; Glutamine; Immune System; Injections, Intraperitoneal; Ionomycin; Ionophores; Leukocyte Count; Lymphocytes; Muscle, Skeletal; Swine; Swine Diseases; Tetradecanoylphorbol Acetate; Thymidine; Weaning | 1997 |
Modulatory effects of PKC activity on increased 92-kDa gelatinase secretion by neonatal alveolar macrophages.
Topics: Aging; Animals; Animals, Newborn; Bucladesine; Cell Membrane; Cells, Cultured; Colforsin; Concanavalin A; Cyclic AMP; Cysteine Endopeptidases; Enzyme Inhibitors; Gelatinases; Gene Expression Regulation, Enzymologic; Kinetics; Macrophages, Alveolar; Molecular Weight; Naphthalenes; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetradecanoylphorbol Acetate | 1997 |
Reductions in the activation of ERK and JNK are associated with decreased IL-2 production in T cells from elderly humans stimulated by the TCR/CD3 complex and costimulatory signals.
Topics: Aged; Aged, 80 and over; Aging; Calcium-Calmodulin-Dependent Protein Kinases; CD3 Complex; Enzyme Activation; Female; Humans; In Vitro Techniques; Interleukin-2; JNK Mitogen-Activated Protein Kinases; Lymphocyte Activation; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Muromonab-CD3; Proto-Oncogene Proteins c-raf; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1997 |
Quantitative intracellular cytokine measurement: age-related changes in proinflammatory cytokine production.
Topics: Adult; Aged; Aging; Analysis of Variance; CD3 Complex; Cytokines; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Interleukin-1; Interleukin-6; Leukocytes, Mononuclear; Lipopolysaccharide Receptors; Middle Aged; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1998 |
Effect of ambroxol on oxygen radical production and generation by bronchoalveolar lavage cells in young and aged guinea pigs.
Topics: Aging; Ambroxol; Animals; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Carcinogens; Cell Count; Dose-Response Relationship, Drug; Expectorants; Guinea Pigs; Leukocyte Count; Lymphocytes; Macrophages; Male; Monocytes; Neutrophils; Reactive Oxygen Species; Tetradecanoylphorbol Acetate | 1998 |
Regulation of the platelet serotonin transporter by protein kinase C in the young and elderly.
Topics: Adult; Aged; Aged, 80 and over; Aging; Binding Sites; Blood Platelets; Carrier Proteins; Enzyme Activation; Female; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Paroxetine; Protein Kinase C; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Tetradecanoylphorbol Acetate | 1999 |
Functional integrity of the CD28 co-stimulatory pathway in T lymphocytes from elderly subjects.
Topics: Adult; Aged; Aging; CD28 Antigens; Cell Division; Female; Humans; Immunophenotyping; Interleukin-2; Male; Mitogens; Receptors, Interleukin-2; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1999 |
Early lymphocyte activation in elderly humans: impaired T and T-dependent B cell responses.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antibodies, Monoclonal; B-Lymphocytes; CD3 Complex; CD40 Ligand; Female; Humans; In Vitro Techniques; Interleukin-4; Lymphocyte Activation; Lymphocyte Cooperation; Male; Membrane Glycoproteins; Receptors, IgE; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1999 |
Effect of aging on CD11b and CD69 surface expression by vesicular insertion in human polymorphonuclear leucocytes.
Topics: Adult; Aged; Aging; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD11 Antigens; Cell Culture Techniques; Dose-Response Relationship, Immunologic; Exocytosis; Female; Humans; Lectins, C-Type; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Tetradecanoylphorbol Acetate | 1999 |
Aminoglycosides activate oxygen metabolites production in the cochlea of mature and developing rats.
Topics: Aging; Animals; Animals, Newborn; Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Cochlea; Drug Synergism; Gentamicins; In Vitro Techniques; Rats; Rats, Wistar; Reactive Oxygen Species; Streptomycin; Tetradecanoylphorbol Acetate | 1999 |
Expression of interleukin-1 receptors in the later period of foetal thymic organ culture and during suspension culture of thymocytes from aged mice.
Topics: Aging; Animals; Animals, Newborn; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Fetus; Flow Cytometry; Fluorescent Antibody Technique; Ionomycin; Ionophores; Lymphocyte Subsets; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Organ Culture Techniques; Receptors, Interleukin-1; Tetradecanoylphorbol Acetate; Thymus Gland; Time Factors | 1999 |
Aging impairs induction of cyclin-dependent kinases and down-regulation of p27 in mouse CD4(+) cells.
Topics: Aging; Animals; Blood Platelets; CD28 Antigens; CD3 Complex; CD4-Positive T-Lymphocytes; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Down-Regulation; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Interleukin-2; Isoantibodies; Kinetics; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microtubule-Associated Proteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Tetradecanoylphorbol Acetate; Tumor Suppressor Proteins | 1999 |
Age-associated impairment in brain MAPK signal pathways and the effect of caloric restriction in Fischer 344 rats.
Topics: Aging; Animals; Apoptosis; Brain; Cell Differentiation; Cell Division; Cerebral Cortex; Cytosol; Energy Intake; Enzyme Activators; Epidermal Growth Factor; Isoenzymes; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitosis; Myelin Sheath; Neurons; p38 Mitogen-Activated Protein Kinases; Phospholipase C gamma; Phosphorylation; Phosphotransferases; Protein-Tyrosine Kinases; Rats; Rats, Inbred F344; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1999 |
Impaired signal transduction in mitogen activated rat splenic lymphocytes during aging.
Topics: Aging; Animals; Calcimycin; Enzyme Activation; In Vitro Techniques; JNK Mitogen-Activated Protein Kinases; Lymphocyte Activation; Lymphocytes; Male; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mitogens; Phosphorylation; Proteins; Rats; Rats, Inbred F344; Signal Transduction; Spleen; Tetradecanoylphorbol Acetate; Transcription Factors; Tyrosine | 2000 |
Induction of adaptation to inhaled lipopolysaccharide in young and old rats and mice.
Topics: Administration, Inhalation; Aging; Animals; Bronchoalveolar Lavage Fluid; Cell Count; Cells, Cultured; Cytokines; Disease Models, Animal; Immune Tolerance; Lipopolysaccharides; Lung; Male; Metallothionein; Mice; Mice, Inbred C57BL; Neutrophils; Pseudomonas aeruginosa; Rats; Rats, Inbred F344; Respiratory Burst; RNA, Messenger; Specific Pathogen-Free Organisms; Tetradecanoylphorbol Acetate | 2000 |
Conversion and storage of somatostatin are established before response to secretagogue stimuli in P19 neurons.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Carcinogens; Cell Differentiation; Central Nervous System; Chromogranin A; Chromogranins; Gene Expression Regulation, Developmental; Ionophores; Mice; Neoplastic Stem Cells; Neurons; Peptide Hydrolases; Phosphodiesterase Inhibitors; Potassium Chloride; Protein Precursors; Proteins; Secretory Vesicles; Somatostatin; Tetradecanoylphorbol Acetate | 2000 |
Altered Th1/Th2 commitment in human CD4+ T cells with ageing.
Topics: Adolescent; Adult; Aged; Aging; B7-1 Antigen; CD3 Complex; CD4-Positive T-Lymphocytes; CD40 Ligand; Cells, Cultured; Dipeptidyl Peptidase 4; Humans; Interferon-gamma; Interleukin-2; Interleukin-4; Intracellular Fluid; Ionomycin; Ki-1 Antigen; Leukocyte Common Antigens; Lymphocyte Function-Associated Antigen-1; Membrane Glycoproteins; Middle Aged; Mitogens; Tetradecanoylphorbol Acetate; Th1 Cells; Th2 Cells | 2000 |
Articular chondrocytes from aging rats respond poorly to insulin-like growth factor-1: an altered signaling pathway.
Topics: Aggrecans; Aging; Animals; Animals, Newborn; Cartilage, Articular; Cells, Cultured; Collagen; Cyclic AMP; DNA; Extracellular Matrix Proteins; Gene Expression; Insulin-Like Growth Factor I; Lectins, C-Type; Male; Proteoglycans; Rats; Rats, Wistar; Signal Transduction; Tetradecanoylphorbol Acetate; Thymidine | 2000 |
Retinoid modulation of plasminogen activator production in rat Sertoli cells.
Topics: Aging; Animals; Cells, Cultured; Dactinomycin; Enzyme Inhibitors; Follicle Stimulating Hormone; Kinetics; Male; Nucleic Acid Synthesis Inhibitors; Protein Kinase C; Rats; Rats, Wistar; RNA, Messenger; Sertoli Cells; Testis; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator; Vitamin A | 2000 |
Diversity of mouse lipoxygenases: identification of a subfamily of epidermal isozymes exhibiting a differentiation-dependent mRNA expression pattern.
Topics: Aging; Animals; Animals, Newborn; Cell Differentiation; Epidermal Cells; Epidermis; Evolution, Molecular; Female; Gastric Mucosa; Gene Expression Regulation, Enzymologic; Isoenzymes; Keratinocytes; Lipoxygenase; Male; Mice; Mice, Inbred Strains; Organ Specificity; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 2000 |
Differential in vitro secretion of gonadotropin-releasing hormone (GnRH) and [hydroxyproline]GnRH from the rat hypothalamus during postnatal development.
Topics: Adenylyl Cyclases; Aging; Animals; Colforsin; Enzyme Activation; Female; Gonadotropin-Releasing Hormone; Hypothalamus; In Vitro Techniques; Male; Potassium; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sexual Maturation; Tetradecanoylphorbol Acetate | 2000 |
RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system.
Topics: Aging; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Conserved Sequence; Diacylglycerol Kinase; Fluorescent Antibody Technique; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Molecular Sequence Data; Mutagenesis, Site-Directed; Nervous System; Nuclear Proteins; Organ Specificity; Phenotype; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Signal Transduction; Synaptic Transmission; Tetradecanoylphorbol Acetate | 2000 |
Age-related decreases in lymphocyte protein kinase C activity and translocation are reduced by aerobic fitness.
Topics: Adult; Aged; Aging; Biological Transport; Exercise; Humans; Lymphocytes; Male; Middle Aged; Oxygen Consumption; Physical Fitness; Phytohemagglutinins; Protein Kinase C; Tetradecanoylphorbol Acetate | 2000 |
Antioxidants may contribute in the fight against ageing: an in vitro model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Antioxidants; Cell Line; Child; Child, Preschool; Disease Susceptibility; Endothelium, Vascular; Enzyme Inhibitors; Glutathione; Humans; Infant; Protein Kinase C; Quercetin; Tetradecanoylphorbol Acetate; Umbilical Veins; Vasculitis | 2000 |
Dmrt1 expression is regulated by follicle-stimulating hormone and phorbol esters in postnatal Sertoli cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aging; Amino Acid Sequence; Animals; Animals, Newborn; Base Sequence; Cells, Cultured; Cloning, Molecular; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA, Complementary; Enzyme Activation; Enzyme Induction; Follicle Stimulating Hormone; Gene Expression; Male; Molecular Sequence Data; Rats; Recombinant Proteins; RNA, Messenger; Sertoli Cells; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic | 2001 |
Retention of oxidized LDL by extracellular matrix proteoglycans leads to its uptake by macrophages: an alternative approach to study lipoproteins cellular uptake.
Topics: Aging; Animals; Apolipoproteins E; Cell Line; Extracellular Matrix; Glycosaminoglycans; Lipopolysaccharides; Lipoprotein Lipase; Lipoproteins; Lipoproteins, LDL; Macrophages; Mice; Mice, Knockout; Oxidation-Reduction; Protein Binding; Proteoglycans; Tetradecanoylphorbol Acetate | 2001 |
Ontogenesis of protein kinase C betaII and its anchoring protein RACK1 in the maturation of alveolar macrophage functional responses.
Topics: Aging; Animals; Cell Differentiation; Cells, Cultured; Hydrogen Peroxide; Interferon-gamma; Isoenzymes; Lipopolysaccharides; Macrophages, Alveolar; Male; Peptides; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Sprague-Dawley; Receptors for Activated C Kinase; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2001 |
Age-dependent skin tumorigenesis and transgene expression in the Tg.AC (v-Ha-ras) transgenic mouse.
Topics: Age Factors; Aging; Animals; Carcinogens; Centrifugation, Density Gradient; Female; Flow Cytometry; Genes, ras; Globins; Integrin beta1; Keratinocytes; Mice; Mice, Transgenic; Neoplasms, Radiation-Induced; Papilloma; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Transgenes; Ultraviolet Rays | 2001 |
Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N-acetyltransferase.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetyltransferases; Aging; Alopecia; Animals; Animals, Newborn; Carcinogens; Mice; Mice, Transgenic; Neoplasm Staging; Ornithine Decarboxylase; Papilloma; Phenotype; Polyamines; Putrescine; Reference Values; Skin; Skin Neoplasms; Spermidine; Tetradecanoylphorbol Acetate; Time Factors | 2001 |
Age-related changes in membrane lipid composition, fluidity and respiratory burst in rat peritoneal neutrophils.
Topics: Aging; Animals; Cholesterol; Cholesterol Esters; Diglycerides; Fatty Acids; Female; Glucosephosphate Dehydrogenase; Membrane Fluidity; Membrane Lipids; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Pentose Phosphate Pathway; Peritoneal Cavity; Phosphogluconate Dehydrogenase; Phospholipids; Rats; Rats, Wistar; Respiratory Burst; Tetradecanoylphorbol Acetate | 2001 |
Effects of macrophage colony-stimulating factor on antifungal activity of neonatal monocytes against Candida albicans.
Topics: Adult; Aging; Candida albicans; Fetal Blood; Humans; Infant, Newborn; Macrophage Colony-Stimulating Factor; Monocytes; Phagocytosis; Superoxides; Tetradecanoylphorbol Acetate | 2001 |
Age-related impairment of human T lymphocytes' activation: specific differences between CD4(+) and CD8(+) subsets.
Topics: Adult; Aged; Aging; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD4 Lymphocyte Count; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Division; Female; Humans; Interferon-gamma; Interleukin-2; Ionomycin; Lectins, C-Type; Lymphocyte Activation; Lymphocyte Count; Male; Middle Aged; Phosphorylation; Phytohemagglutinins; Receptors, Antigen, T-Cell; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 2002 |
Differences in the expression of protein kinase C isoforms and its translocation after stimulation with phorbol ester between young-adult and middle-aged ventricular cardiomyocytes isolated from Fischer 344 rats.
Topics: Aging; Animals; Gene Expression; Heart Ventricles; Immunohistochemistry; Isoenzymes; Male; Myocardium; Protein Kinase C; Rats; Rats, Inbred F344; Tetradecanoylphorbol Acetate; Translocation, Genetic | 2001 |
Pre- and postsynaptic maturation of the neuromuscular junction during neonatal synapse elimination depends on protein kinase C.
Topics: Aging; Animals; Animals, Newborn; Anterior Horn Cells; Axons; Cell Differentiation; Fluorescent Antibody Technique; Male; Muscle, Skeletal; Naphthalenes; Neuromuscular Junction; Neuronal Plasticity; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Synaptic Membranes; Tetradecanoylphorbol Acetate | 2002 |
Taurine release in the developing and adult mouse hippocampus: involvement of cyclic guanosine monophosphate.
Topics: Aging; Animals; Animals, Newborn; Brain Ischemia; Cyclic AMP; Enzyme Inhibitors; Female; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Nitric Oxide; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Reference Values; Taurine; Tetradecanoylphorbol Acetate | 2002 |
Lymphocyte stimulation with phorbol myristate acetate in atopic and non-atopic individuals.
Topics: Adolescent; Adult; Aging; Cells, Cultured; Child; Child, Preschool; Concanavalin A; DNA; Female; Humans; Hypersensitivity, Immediate; Infant, Newborn; Lymphocyte Activation; Male; Phorbols; Phytohemagglutinins; Pokeweed Mitogens; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1979 |
Effect of aging in two-stage carcinogenesis on mouse skin with phorbol myristate acetate as promoting agent.
Topics: Aging; Animals; Female; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Phorbols; Skin Neoplasms; Statistics as Topic; Tetradecanoylphorbol Acetate | 1978 |
On the existence of 'arrested G2 cells' in mouse epidermis.
Topics: Aging; Animals; Cell Cycle; DNA; Epidermal Cells; Female; Interphase; Mice; Mitosis; Photometry; Tetradecanoylphorbol Acetate | 1978 |
Age-related changes in the expression of T cell activation antigens following phytohaemagglutinin stimulation.
Topics: Aged; Aged, 80 and over; Aging; Antigen-Presenting Cells; Antigens, CD; Cell Division; Female; HLA-DR Antigens; Humans; Interleukin-2; Lymphocyte Activation; Male; Monocytes; Muromonab-CD3; Phytohemagglutinins; T-Lymphocyte Subsets; Tetradecanoylphorbol Acetate | 1992 |
Age-related alterations in superoxide anion generation in mouse peritoneal macrophages studied by repeated stimulations and heat shock treatment.
Topics: Aging; Animals; Female; Hot Temperature; Macrophages; Mice; NADH, NADPH Oxidoreductases; NADPH Oxidases; Oxygen; Peritoneal Cavity; Respiratory Burst; Shock; Stimulation, Chemical; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1992 |
Age-related changes in the mechanisms of LHRH-stimulated LH release from pituitary cells in vitro.
Topics: Aging; Analysis of Variance; Animals; Buserelin; Calcimycin; Calcium Channels; Cells, Cultured; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Male; Nifedipine; Pituitary Gland, Anterior; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, LHRH; Tetradecanoylphorbol Acetate | 1992 |
Intracellular free Ca2+ fluxes and responses to phorbol ester in T lymphocytes from healthy elderly subjects.
Topics: Adult; Aged; Aging; Antigens, Differentiation, T-Lymphocyte; Calcium; CD3 Complex; Cell Division; Female; Humans; Immunity, Cellular; In Vitro Techniques; Ionomycin; Male; Phytohemagglutinins; Protein Kinase C; Receptors, Antigen, T-Cell; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1992 |
Monoclonal antibody analysis of phosphatidylserine and protein kinase C localizations in developing rat cerebellum.
Topics: Aging; Animals; Antibodies, Monoclonal; Cerebellum; Cytosol; Immunohistochemistry; Nerve Tissue Proteins; Phosphatidylserines; Protein Kinase C; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Tissue Distribution | 1992 |
Protein kinase-C activity in phorbol myristate acetate-stimulated neutrophils from newborn and adult cattle.
Topics: Aging; Animals; Animals, Newborn; Cattle; Cell Membrane; Cell Survival; Cells, Cultured; Cytosol; Female; Leukocyte Count; Male; Neutrophils; Protein Kinase C; Tetradecanoylphorbol Acetate | 1992 |
Effects of phorbol myristate and ionomycin on in vitro growth of aged Peyer's patch T and B cells.
Topics: Aging; Animals; B-Lymphocytes; Cell Division; Concanavalin A; Interleukin-2; Ionomycin; Male; Mice; Mice, Inbred BALB C; Peyer's Patches; Signal Transduction; Specific Pathogen-Free Organisms; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1992 |
The effect of taurine on the age-related decline of the immune response in mice: the restorative effect on the T cell proliferative response to costimulation with ionomycin and phorbol myristate acetate.
Topics: Aging; Animals; Antibody Formation; B-Lymphocytes; Calcium; Cell Division; Cells, Cultured; Ionomycin; Lymphocyte Subsets; Mice; Mice, Inbred BALB C; Spleen; T-Lymphocytes; Taurine; Tetradecanoylphorbol Acetate | 1992 |
Ontogeny of surfactant secretion in type II pneumocytes from fetal, newborn, and adult rats.
Topics: Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Aging; Animals; Animals, Newborn; Female; In Vitro Techniques; Ionomycin; Kinetics; Lung; Male; Phospholipids; Pregnancy; Pulmonary Surfactants; Rats; Rats, Inbred Strains; Terbutaline; Tetradecanoylphorbol Acetate | 1992 |
Elevated levels of c-jun and c-fos transcripts in the aged rat liver.
Topics: Aging; Animals; Blotting, Northern; DNA Probes; DNA-Binding Proteins; Female; Gene Expression; Glutathione Transferase; Liver; Male; Poly A; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; Rats; Rats, Inbred Strains; RNA; RNA, Messenger; Sex Characteristics; Tetradecanoylphorbol Acetate; Transcription Factors | 1991 |
Effect of aging on the sensitivity of pancreatic beta-cells to insulin secretagogues in rats.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Blood Glucose; Female; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Tolbutamide | 1991 |
In vivo T cell activation, in vitro defective IL-2 secretion, and response to influenza vaccination in elderly women.
Topics: Aged; Aged, 80 and over; Aging; Antibodies, Viral; Cells, Cultured; Humans; In Vitro Techniques; Influenza A virus; Influenza Vaccines; Interleukin-2; Lymphocyte Activation; Phytohemagglutinins; T-Lymphocytes; Tetradecanoylphorbol Acetate; Vaccination | 1992 |
Assessment of the antioxidant/prooxidant status of murine skin following topical treatment with 12-O-tetradecanoylphorbol-13-acetate and throughout the ontogeny of skin cancer. Part II: Quantitation of glutathione and glutathione disulfide.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Administration, Topical; Aging; Animals; Carcinoma, Squamous Cell; Epidermis; Female; Glutathione; Glutathione Disulfide; Mice; Oxidation-Reduction; Oxygen; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Induction of metallothionein in rats.
Topics: Adenosine; Aging; Animals; Catecholamines; Glucocorticoids; Hormones; Liver; Metallothionein; Metals; Peptides; Rats; Tetradecanoylphorbol Acetate; Xanthines | 1991 |
Postnatal development of murine spleen cell proliferative responses induced by interleukin 2 or phorbol ester and calcium ionophore A23187.
Topics: Aging; Animals; Calcimycin; Interleukin-2; Lymphocyte Activation; Lymphocytes; Mice; Mice, Inbred A; Mice, Inbred AKR; Mice, Inbred C3H; Spleen; Tetradecanoylphorbol Acetate | 1991 |
The effects of age on the postreceptor regulation of luteinizing hormone secretion by gonadotropin-releasing hormone.
Topics: Aging; Animals; Buserelin; Cells, Cultured; Female; Gonadotropin-Releasing Hormone; Inositol Phosphates; Kinetics; Luteinizing Hormone; Mice; Mice, Inbred C57BL; Ovariectomy; Pituitary Gland; Receptors, LH; Second Messenger Systems; Tetradecanoylphorbol Acetate | 1991 |
Impaired responsiveness of IL-2 receptor-expressing T lymphocytes from aged mice.
Topics: Aging; Animals; Cell Cycle; DNA; Interleukin-2; Ionomycin; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Receptors, Interleukin-2; Signal Transduction; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Tetradecanoylphorbol Acetate | 1991 |
Signaling through surface IgM in tolerance-susceptible immature murine B lymphocytes. Developmentally regulated differences in transmembrane signaling in splenic B cells from adult and neonatal mice.
Topics: Aging; Animals; Animals, Newborn; B-Lymphocytes; Calcium; Cell Cycle; Cross-Linking Reagents; Immune Tolerance; Immunoglobulin M; Ionomycin; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Phosphatidylinositols; Receptors, Antigen, B-Cell; Signal Transduction; Spleen; Tetradecanoylphorbol Acetate | 1991 |
Characterization of an 8-lipoxygenase activity induced by the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate in mouse skin in vivo.
Topics: Aging; Animals; Arachidonate Lipoxygenases; Catalysis; Chromatography, Gas; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Enzyme Activation; Female; Hydrogen-Ion Concentration; Hydroxyeicosatetraenoic Acids; Kinetics; Leukotrienes; Liposomes; Mice; Phosphatidylcholines; Skin; Tetradecanoylphorbol Acetate | 1991 |
Phorbol myristate acetate corrects impaired NK function of old mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Animals; Cell Adhesion; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Isoquinolines; Killer Cells, Natural; Mice; Mice, Inbred C3H; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Tetradecanoylphorbol Acetate | 1991 |
Characterization of ouabain-induced phosphoinositide hydrolysis in brain slices of the neonatal rat.
Topics: Aging; Animals; Animals, Newborn; Brain; Calcium; Cerebral Cortex; Female; Hydrolysis; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kinetics; Male; Ouabain; Phosphatidylinositols; Rats; Rats, Inbred Strains; Strophanthidin; Tetradecanoylphorbol Acetate | 1990 |
Superoxide radical production after phorbol ester stimulation in neutrophils of aged donors.
Topics: Adult; Aged; Aging; Blood Proteins; Free Radicals; Humans; In Vitro Techniques; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Impairment of CD3-dependent and CD3-independent activation pathways in CD4+ and in CD8+ T cells from old CBA/RIJ mice.
Topics: Aging; Animals; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; CD4-Positive T-Lymphocytes; CD8 Antigens; In Vitro Techniques; Interleukin-2; Ionomycin; Lymphocyte Activation; Male; Mice; Mice, Inbred CBA; Receptors, Antigen, T-Cell; Receptors, Interleukin-2; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1990 |
Age-related changes in release of soluble interleukin-2 receptor by murine lymphocytes.
Topics: Aging; Animals; Antibodies, Monoclonal; Concanavalin A; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Lymphocyte Activation; Lymphocytes; Mice; Mice, Inbred C57BL; Receptors, Interleukin-2; Spleen; Tetradecanoylphorbol Acetate | 1991 |
Protein kinase C activity and contractile responsiveness in senescent blood vessels.
Topics: Aging; Animals; Aorta, Thoracic; Cerebral Cortex; Diglycerides; Male; Muscle Contraction; Muscle, Smooth, Vascular; Protein Kinase C; Rats; Rats, Inbred F344; Signal Transduction; Tetradecanoylphorbol Acetate | 1990 |
Cord blood B cells are mature in their capacity to switch to IgE-producing cells in response to interleukin-4 in vitro.
Topics: Aging; Antibodies, Monoclonal; B-Lymphocytes; Cells, Cultured; Concanavalin A; Female; Fetal Blood; Humans; Immunoglobulin E; Interferon-gamma; Interleukin-2; Interleukin-4; Lymphocyte Activation; Phytohemagglutinins; Pregnancy; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1990 |
Production of phosphatidylethanol by phospholipase D phosphatidyl transferase in intact or dispersed pancreatic islets: evidence for the in situ metabolism of phosphatidylethanol.
Topics: Aging; Animals; Animals, Newborn; Arachidonic Acid; Arachidonic Acids; In Vitro Techniques; Ionomycin; Islets of Langerhans; Kinetics; Male; Myristic Acid; Myristic Acids; Phospholipase D; Phospholipids; Rats; Rats, Inbred Strains; Stearic Acids; Tetradecanoylphorbol Acetate | 1990 |
IL-3 production as a function of age and its correlation with splenomegaly: age versus disease-related change.
Topics: Aging; Animals; Calcimycin; Cells, Cultured; Female; Gene Expression Regulation; Interleukin-3; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Splenomegaly; T-Lymphocytes, Helper-Inducer; Tetradecanoylphorbol Acetate | 1990 |
Polymorphism of age-related changes in interleukin (IL) production: differential changes of T helper subpopulations, synthesizing IL 2, IL 3 and IL 4.
Topics: Aging; Animals; Calcimycin; Concanavalin A; Female; Interleukin-2; Interleukin-3; Interleukin-4; Mice; Mice, Inbred Strains; Polymorphism, Genetic; T-Lymphocytes, Helper-Inducer; Tetradecanoylphorbol Acetate | 1990 |
Effect of age on phorbol-ester stimulation of human neutrophils.
Topics: Adult; Aged; Aged, 80 and over; Aging; Caenorhabditis elegans Proteins; Carrier Proteins; Female; Humans; Male; Neutrophils; Phosphorylation; Protein Kinase C; Receptors, Drug; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Membrane NADPH oxidase activity and cell size in bovine neonatal and adult neutrophils.
Topics: Aging; Animals; Animals, Newborn; Cattle; Cell Membrane; Female; Kinetics; Male; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
The effect of taurine on age-related immune decline in mice: the effect of taurine on T cell and B cell proliferative response under costimulation with ionomycin and phorbol myristate acetate.
Topics: Aging; Animals; Calcium; Immune System; Ionomycin; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Spleen; Taurine; Tetradecanoylphorbol Acetate | 1990 |
Production of procollagenase by cultured human keratinocytes.
Topics: Adult; Aging; Cells, Cultured; Collagenases; Enzyme Precursors; Fluorescent Antibody Technique; Humans; Infant, Newborn; Keratins; Kinetics; Male; Microbial Collagenase; Skin; Tetradecanoylphorbol Acetate | 1987 |
Age-related impairment in the short term regulation of insulin biosynthesis by glucose in rat pancreatic islets.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Aging; Animals; Dactinomycin; Electrophoresis, Polyacrylamide Gel; Glucose; Insulin; Islets of Langerhans; Male; Proinsulin; Protein Kinase C; Protein Precursors; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1988 |
Effect of age on brain cortical protein kinase C and its mediation of 5-hydroxytryptamine release.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Animals; Calcimycin; Calcium; Cerebral Cortex; Isoquinolines; Piperazines; Protein Kinase C; Rats; Rats, Inbred F344; Serotonin; Tetradecanoylphorbol Acetate | 1989 |
Expression of interleukin 2 and the interleukin 2 receptor in aging rats.
Topics: Aging; Animals; Blotting, Northern; Calcimycin; Cells, Cultured; Concanavalin A; Gene Expression Regulation; Interleukin-2; Lymphocyte Activation; Rats; Rats, Inbred F344; Receptors, Interleukin-2; RNA, Messenger; Spleen; Tetradecanoylphorbol Acetate | 1989 |
Developmental changes in galactosyltransferase activity in the rat small intestine.
Topics: Aging; Animals; Cortisone; Female; Intestinal Mucosa; Intestine, Small; Kinetics; Lactose Synthase; N-Acetyllactosamine Synthase; Rats; Rats, Inbred Strains; Reference Values; Tetradecanoylphorbol Acetate | 1989 |
Interleukin 2, interleukin 2 receptor, and interferon-gamma synthesis and mRNA expression in phorbol myristate acetate and calcium ionophore A23187-stimulated T cells from elderly humans.
Topics: Adult; Aged; Aging; Calcimycin; Gene Expression Regulation; Humans; Interferon-gamma; Interleukin-2; Lymphocyte Activation; Receptors, Interleukin-2; RNA, Messenger; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1989 |
Synergisms between different activation pathways in adult and aged human lymphocytes.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antigens, Differentiation, T-Lymphocyte; Antilymphocyte Serum; CD3 Complex; Female; Humans; Ionomycin; Lymphocyte Activation; Male; Phytohemagglutinins; Receptors, Antigen, T-Cell; Tetradecanoylphorbol Acetate | 1989 |
Relationship between superoxide anion radical generation and aging in the housefly, Musca domestica.
Topics: Aging; Animals; Antimycin A; Cytochrome c Group; Drug Resistance; Houseflies; Life Expectancy; Mitochondria; Motor Activity; Oxygen Consumption; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate; Ubiquinone | 1989 |
Calcium- versus G-protein-activated phosphoinositide hydrolysis in synaptoneurosomes from young and old rats.
Topics: Aging; Animals; Calcium; GTP-Binding Proteins; Hydrolysis; Phosphatidylinositols; Rats; Rats, Inbred F344; Synaptosomes; Tetradecanoylphorbol Acetate | 1989 |
Pgp-1hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A.
Topics: Aging; Animals; Antigens, Surface; Concanavalin A; Ethers; Flow Cytometry; Immunologic Memory; Ionomycin; Lymphocyte Activation; Membrane Glycoproteins; Mice; Receptors, Lymphocyte Homing; Spleen; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1989 |
Thymic stroma-derived T cell growth factor (TSTGF). IV. Capacity of TSTGF to promote the growth of L3T4- Lyt-2- thymocytes by synergy with phorbol myristate acetate or various IL.
Topics: Adjuvants, Immunologic; Aging; Animals; Antigens, Differentiation, T-Lymphocyte; Cell Division; Drug Combinations; Drug Synergism; Extracellular Matrix; Interleukin-2; Interleukins; Lymphocyte Activation; Mice; Mice, Inbred C3H; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymus Gland | 1989 |
Differences in the pattern of proliferative response with age in thymocytes undergoing spontaneous and induced proliferation.
Topics: Aging; Animals; Concanavalin A; DNA Replication; Ionomycin; Lymphocyte Activation; Mice; Mice, Inbred C3H; Nuclear Proteins; Organ Size; Tetradecanoylphorbol Acetate; Thymus Gland | 1989 |
Developmental changes of the alpha-1-adrenergic receptor system in rat liver.
Topics: Aging; Animals; Binding, Competitive; Blood Glucose; Calcimycin; Gluconeogenesis; Glucose; Guanylyl Imidodiphosphate; In Vitro Techniques; Liver; Male; Norepinephrine; Prazosin; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tetradecanoylphorbol Acetate | 1987 |
Characterization of a cell surface-expressed disulfide-linked dimer involved in murine T cell activation.
Topics: Aging; Animals; Antibodies, Monoclonal; Antigen-Presenting Cells; Antigens, Surface; Cricetinae; Disulfides; Lymphocyte Activation; Mice; Mice, Inbred C3H; Molecular Weight; Protein Conformation; Structure-Activity Relationship; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor Receptor Superfamily, Member 7 | 1988 |
Studies on opsonized zymozan, FMLP, carbachol, PMA and A23187 stimulated respiratory burst of human PMNLs.
Topics: Adult; Aging; Calcimycin; Carbachol; Humans; In Vitro Techniques; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1988 |
Diminished pituitary responsiveness to growth hormone-releasing factor in aging male rats.
Topics: Aging; Animals; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Growth Hormone; Growth Hormone-Releasing Hormone; Kinetics; Male; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1986 |
Synergistic induction by calcium ionophore and phorbol ester of interleukin-2 (IL-2) receptor expression, IL-2 production, and proliferation in autoimmune MRL/MP-lpr mice.
Topics: Aging; Animals; Calcimycin; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Flow Cytometry; Interleukin-2; Lymphocyte Activation; Male; Mice; Mice, Inbred Strains; Mitosis; Receptors, Immunologic; Receptors, Interleukin-2; Spleen; Tetradecanoylphorbol Acetate | 1986 |
Age-related defect in signal transduction during lectin activation of murine T lymphocytes.
Topics: Aging; Animals; Biological Transport; Calcium; Concanavalin A; Female; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Interleukin-2; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Protein Kinase C; Receptors, Immunologic; Receptors, Interleukin-2; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1987 |
Correction in vitro of lymphocyte activation defect in autoimmune mice.
Topics: Aging; Animals; Autoimmune Diseases; Calcimycin; Concanavalin A; DNA; Gene Expression Regulation; Interleukin-2; Lymphocyte Activation; Male; Mice; Proto-Oncogenes; Receptors, Immunologic; Receptors, Interleukin-2; Tetradecanoylphorbol Acetate | 1987 |
Impaired phorbol ester and calcium ionophore induced proliferation of T cells from old humans.
Topics: Adult; Aged; Aging; Calcimycin; Humans; Interleukin-2; Lymphocyte Activation; Middle Aged; Receptors, Immunologic; Receptors, Interleukin-2; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymidine | 1987 |
Age-related changes of proliferative response, kinetics of expression of protooncogenes after the mitogenic stimulation and methylation level of the protooncogene in purified human lymphocyte subsets.
Topics: Aging; B-Lymphocytes; Ethers; Humans; Ionomycin; Methylation; Oncogenes; Proto-Oncogenes; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1988 |
Immunodeficiency of aging: restorative effects of phorbol ester combined with calcium ionophore.
Topics: Aging; Animals; DNA; Dose-Response Relationship, Immunologic; Drug Combinations; Ethers; Immunologic Deficiency Syndromes; Interphase; Ionomycin; Ionophores; Lymphocyte Activation; Mice; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1986 |
Relationships between non organ-specific autoantibody production and age-related modifications of mononuclear cell phenotype.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antibodies, Monoclonal; Antigens, Surface; Autoantibodies; B-Lymphocytes; Humans; Lymphocyte Activation; Lymphocytes; Middle Aged; Organ Specificity; Phenotype; Rheumatoid Factor; Rosette Formation; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1986 |
Evidence for a role of the plasma kallikrein-kinin system in acute inflammation: reduced exudation during carrageenin- and kaolin-pleurisies in kininogen-deficient rats.
Topics: Acute Disease; Aging; Animals; Body Weight; Carrageenan; Inflammation; Kallikreins; Kaolin; Kininogens; Kinins; Organ Size; Pleurisy; Rats; Rats, Inbred Strains; Species Specificity; Tetradecanoylphorbol Acetate | 1986 |
Age-related decline in ligand-induced actin polymerization in human leukocytes and platelets.
Topics: Actins; Adult; Aged; Aging; Blood Platelets; Female; Humans; In Vitro Techniques; Ligands; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenylephrine; Tetradecanoylphorbol Acetate; Triiodothyronine | 1986 |
Pathology of aging female SENCAR mice used as controls in skin two-stage carcinogenesis studies.
Topics: Acetone; Aging; Animals; Cardiovascular System; Female; Genitalia, Female; Hematopoietic System; Kidney; Liver; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Respiratory System; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Isolation and characterization of chemically transformed pancreatic acinar cell lines from young and old mice.
Topics: Acetylglucosamine; Aging; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Isoenzymes; Karyotyping; L-Lactate Dehydrogenase; Lectins; Male; Methylnitrosourea; Mice; Pancreatic Neoplasms; Phenotype; Plant Lectins; Soybean Proteins; Tetradecanoylphorbol Acetate | 1987 |
Papilloma development on young and senescent mouse skin treated with 12-O-tetradecanoylphorbol 13-acetate.
Topics: Aging; Animals; Hyperplasia; Mice; Mice, Inbred BALB C; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Proliferative response in solid culture of T cells from healthy aged subjects.
Topics: Adolescent; Adult; Aged; Aging; Cell Survival; Culture Media; Erythrocytes; Humans; Lymphocyte Activation; Mercaptoethanol; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1985 |
Initiation and promotion in young and old animals. Implications for human tumour formation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Autopsy; Female; Humans; Mathematics; Mice; Models, Biological; Neoplasms; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |