tetracycline and Zoonoses

Equine granulocytic anaplasmosis (EGA) is an important tick borne disease of equines that is caused by Anaplasma phagocytophilum (A. phagocytophilum). The etiological agent has veterinary as well as public health importance because of its zoonotic nature. A. phagocytophilum causes an acute illness in equines with loss of appetite, lethargy, hemorrhages and lameness. Clinically, EGA is diagnosed upon examination of morulae within neutrophils especially granulocytes in the blood. The best diagnostic tool for the detection of EGA is Polymerase chain reaction (PCR). Previous studies suggested that EGA is a self-limiting disease and tetracycline therapy is considered as a best treatment regimen. There is no comprehensive summary on the occurrence and distribution of the infection at global level. Therefore, we intended to provide a comprehensive summary on the prevalence and epidemiology of EGA in different areas of the world. It includes mapping the global distribution of EGA in different areas of the world to identify the endemic regions which may be a source of potential disease outbreak. For this purpose, the published data from 1990 to 2018 on EGA was reviewed and collected by electronic literature search of five databases including Google, Google Scholar, Science Direct, PubMed and Web of Science.

Topics: Anaplasma phagocytophilum; Anaplasmosis; Animals; Anti-Bacterial Agents; Databases, Factual; Disease Outbreaks; Disease Transmission, Infectious; Granulocytes; Horse Diseases; Horses; Prevalence; Tetracycline; Tick-Borne Diseases; Ticks; Zoonoses

Topics: Animals; Anti-Bacterial Agents; Diagnosis, Differential; Finger Injuries; Humans; Mycoplasma; Mycoplasma Infections; Seals, Earless; Tetracycline; Zoonoses

A 57-year-old man with symptoms and signs consistent with atypical pneumonia had epidemiologic and later serologic evidence of psittacosis pneumonia. Therapy with tetracycline resulted in rapid resolution.

Topics: Ciprofloxacin; Diagnosis, Differential; Humans; Male; Middle Aged; Pneumonia, Mycoplasma; Psittacosis; Tetracycline; Zoonoses

Topics: Adolescent; Adult; Animals; Carrier State; Child; Demography; Diagnosis, Differential; Humans; Leptospira; Leptospirosis; Male; Middle Aged; Occupational Diseases; Penicillins; Seasons; Serologic Tests; Serotyping; Tetracycline; United States; Water Microbiology; Zoonoses

Topics: Animal Diseases; Animal Feed; Animals; Anti-Bacterial Agents; Bacteria; Bacteroides; Cattle; Chickens; Clostridium; Corynebacterium; Digestive System; Drug Resistance, Microbial; Enterobacteriaceae; Erysipelothrix; Escherichia coli; Feces; Genetics, Microbial; Humans; Mycoplasma; Pasteurella; Salmonella; Sheep; Species Specificity; Staphylococcus; Streptococcus; Streptococcus pyogenes; Swine; Tetracycline; Zoonoses

Topics: Animals; Birds; Chick Embryo; Chlamydia; Chlamydia Infections; Complement Fixation Tests; DNA, Bacterial; Female; Fluorescent Antibody Technique; Hemagglutination Inhibition Tests; History, 19th Century; History, 20th Century; Humans; Lung; Male; Mice; Neutralization Tests; Psittaciformes; Psittacosis; RNA, Bacterial; Sputum; Sulfadiazine; Tetracycline; United States; Virulence; Zoonoses

Extraintestinal pathogenic Escherichia coli (ExPEC) cause clinical infections in humans. Understanding the evolution and dissemination of ExPEC strains via potential reservoirs is important due to associated morbidity, health care costs and mortality. To further understanding this survey has examined isolates recovered from the faeces of 221 healthy dogs and 427 healthy cats. The distribution of phylogroups varied with host species, and depended on whether the animal was living in a shelter or a home. The human associated STs 69, 73, 95, 131 and 127 were prevalent, with 30.5% of cat isolates and 10.3% of dog isolates representing these ExPEC sequence types. Resistance to the antibiotics ampicillin and tetracycline was common, but resistance to other antimicrobials was negligible.

Topics: Ampicillin; Animals; Australia; Cats; Disease Reservoirs; Dogs; Drug Resistance, Multiple, Bacterial; Escherichia coli Infections; Extraintestinal Pathogenic Escherichia coli; Feces; Female; Genotype; Humans; Male; Microbial Sensitivity Tests; Phylogeny; Tetracycline; Zoonoses

The spread of livestock-associated methicillin-resistant

Topics: Animals; Anti-Bacterial Agents; Denmark; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Farms; Genome, Bacterial; Humans; Livestock; Methicillin-Resistant Staphylococcus aureus; Prevalence; Staphylococcal Infections; Swine; Swine Diseases; Tetracycline; Whole Genome Sequencing; Zoonoses

Clinically healthy homing pigeons may serve as an unnoticed reservoir for zoonotic bacteria. Hence, healthy pigeons from 172 different racing pigeon lofts were examined for Salmonella serovars, Campylobacter spp. and Chlamydophila (Chlamydia) psittaci. Two samplings were performed during the racing season in summer (1242 adult and 1164 juvenile pigeons) and two during winter (1074 adult pigeons). Each sampling was accompanied by a questionnaire to identify risk factors for positive lofts. Between 0.9 and 3.7%, 13.1 and 23.7%, and 12.8 and 42.6% of lofts were tested positive by cultural methods or polymerase chain reaction for Salmonella Typhimurium var. Copenhagen, Campylobacter jejuni and C. psittaci, respectively. The detection rate of C. psittaci was twice as high in samples from juvenile pigeons (29.1%) compared with samples from adult pigeons (15.0%, P <0.001). No other influence of age or season was detected. For the first time, pigeon-derived C. jejuni isolates (n=15) were characterized for their ability to invade human enterocytes in vitro. All isolates were invasive with an invasion index between 0.4 and 34.1 (human reference strain: average 11.3). Of 50 C. jejuni isolates tested for antimicrobial susceptibility, 46.0% were resistant to ciprofloxacin. All isolates were sensitive to erythromycin and tetracycline. The analysis of risk factors in association with the infection status of lofts for C. jejuni and C. psittaci suggested that biosecurity measures reduce the risk of infection. This study indicated a zoonotic potential of pigeon-derived C. jejuni. However, clinically healthy homing pigeons pose only a low risk for transmission of the investigated pathogens to humans.

Topics: Adult; Animals; Anti-Bacterial Agents; Bird Diseases; Caco-2 Cells; Campylobacter Infections; Campylobacter jejuni; Chlamydophila psittaci; Ciprofloxacin; Columbidae; Erythromycin; Germany; Humans; Incidence; Male; Phenotype; Psittacosis; Risk Factors; Salmonella Infections, Animal; Salmonella typhimurium; Tetracycline; Zoonoses

Topics: Animals; Anti-Bacterial Agents; Bites and Stings; Finger Injuries; Fur Seals; Humans; Male; Mycoplasma Infections; Pasteurellaceae; Pasteurellaceae Infections; Seals, Earless; Tetracycline; Zoonoses

Since its discovery in the early 2000s, methicillin-resistant Staphylococcus aureus (MRSA) clonal complex 398 (CC398) has become a rapidly emerging cause of human infections, most often associated with livestock exposure. We applied whole-genome sequence typing to characterize a diverse collection of CC398 isolates (n = 89), including MRSA and methicillin-susceptible S. aureus (MSSA) from animals and humans spanning 19 countries and four continents. We identified 4,238 single nucleotide polymorphisms (SNPs) among the 89 core genomes. Minimal homoplasy (consistency index = 0.9591) was detected among parsimony-informative SNPs, allowing for the generation of a highly accurate phylogenetic reconstruction of the CC398 clonal lineage. Phylogenetic analyses revealed that MSSA from humans formed the most ancestral clades. The most derived lineages were composed predominantly of livestock-associated MRSA possessing three different staphylococcal cassette chromosome mec element (SCCmec) types (IV, V, and VII-like) including nine subtypes. The human-associated isolates from the basal clades carried phages encoding human innate immune modulators that were largely missing among the livestock-associated isolates. Our results strongly suggest that livestock-associated MRSA CC398 originated in humans as MSSA. The lineage appears to have undergone a rapid radiation in conjunction with the jump from humans to livestock, where it subsequently acquired tetracycline and methicillin resistance. Further analyses are required to estimate the number of independent genetic events leading to the methicillin-resistant sublineages, but the diversity of SCCmec subtypes is suggestive of strong and diverse antimicrobial selection associated with food animal production.. Modern food animal production is characterized by densely concentrated animals and routine antibiotic use, which may facilitate the emergence of novel antibiotic-resistant zoonotic pathogens. Our findings strongly support the idea that livestock-associated MRSA CC398 originated as MSSA in humans. The jump of CC398 from humans to livestock was accompanied by the loss of phage-carried human virulence genes, which likely attenuated its zoonotic potential, but it was also accompanied by the acquisition of tetracycline and methicillin resistance. Our findings exemplify a bidirectional zoonotic exchange and underscore the potential public health risks of widespread antibiotic use in food animal production.

Topics: Adaptation, Biological; Animals; Bacterial Typing Techniques; Bacteriophages; Chromosomes, Bacterial; Communicable Diseases, Emerging; Food Microbiology; Genome, Bacterial; Humans; Livestock; Methicillin; Methicillin Resistance; Phylogeny; Polymorphism, Single Nucleotide; Staphylococcal Infections; Staphylococcus aureus; Tetracycline; Virulence Factors; Zoonoses

Tick bite fever (TBF) and Q fever are zoonotic infections, highly prevalent in southern Africa, which are caused by different genera of obligate intracellular bacteria. While TBF was first described nearly 100 years ago, it has only recently been discovered that there are several rickettsial species transmitted in southern Africa, the most common of which is Rickettsia africae. This helps to explain the highly variable clinical presentation of TBF, ranging from mild to severe or even fatal, that has always been recognised. Q fever, caused by Coxiella burnetii, is a protean disease that is probably extensively under-diagnosed. Clinically, it also shows a wide spectrum of severity, with about 60% of cases being clinically inapparent. Unlike TBF, Q fever may cause chronic infection, and a post-Q fever chronic fatigue syndrome has been described. The molecular pathophysiology of these diseases provides insight into different strategies that intracellular parasites may use to survive and cause disease. While newer macrolide and quinolone antibiotics show activity against these pathogens and may be useful in young children and pregnant women, the treatment of choice for acute infection in both diseases is still tetracycline-group antibiotics. Chronic Q fever remains challenging to treat.

Topics: Animals; Boutonneuse Fever; Child, Preschool; Female; Humans; Pregnancy; Pregnancy Complications, Infectious; Q Fever; Rickettsia Infections; South Africa; Tetracycline; Tick-Borne Diseases; Zoonoses

Topics: Adult; Chlamydophila psittaci; Diagnosis, Differential; Female; Humans; Meningism; Psittacosis; Tetracycline; Zoonoses

Pneumonia is one of several clinical syndromes that results from inhalation of Coxiella burnetii. This microorganism, the etiologic agent of "Q" (query) fever, infects a wide range of animals and insects. Cattle, sheep, goats, and cats are the reservoirs whereby this agent is spread to humans. High concentrations of C burnetii are present in the placenta and at parturition, the organism is shed into the environment to be inhaled by humans. Following an incubation period that ranges from four to 30 days (mean 14 days), fever, headache, malaise, and cough ensue. The clinical presentation of pneumonia may range from a mild to a severe illness--the latter with the clinical picture of rapidly progressive pneumonia. There are no characteristic features of Q fever pneumonia but the severe headache and the epidemiological history should serve as clues. Treatment with tetracycline or rifampin for two weeks usually results in cure. Many cases of Q fever pneumonia remit without antibiotic therapy. The diagnosis is usually confirmed serologically using a complement fixation or microimmunofluorescence test.

Topics: Animals; Coxiella; Humans; Pneumonia; Q Fever; Radiography; Tetracycline; Zoonoses

Topics: Animals; Animals, Domestic; Child, Preschool; Chloramphenicol; Ehrlichia; Humans; Male; Meningitis; Meningitis, Aseptic; Rickettsiaceae; Rickettsiaceae Infections; Tetracycline; Zoonoses

Topics: Animals; Antibodies, Bacterial; Chronic Disease; Coxiella; Humans; Q Fever; Tetracycline; Zoonoses

We have reported a case documenting the difficulties encountered in diagnosing and treating patients with brucellosis caused by Brucella canis, including the nonspecific clinical presentation, low level of intermittent bacteremias, the slow-growing, fastidious nature of the organism, and the lack of antigenic cross-reactivity with the antigens usually used in routine Brucella serology. Further, the predominant southeastern United States epidemiology of this organism and the importance of exposure to dogs are also demonstrated by this report. It is important that physicians caring for patients in this region of the country be aware of the epidemiologic, serologic, and microbiologic pitfalls encountered in diagnosing B canis infections.

Topics: Animals; Brucella; Brucellosis; Dog Diseases; Dogs; Fever of Unknown Origin; Humans; Male; Streptomycin; Tetracycline; Zoonoses

A 58-year-old woman with prolonged febrile illness was found to have brucellosis caused by Brucella canis, presumably acquired through contact with infected dogs. After initial laboratory tests failed to yield a diagnosis, the disease was confirmed by the Brucella agglutination test. A combination of tetracycline and streptomycin therapy was begun, and the illness resolved. B canis, a recently recognized cause of human brucellosis, must now be considered in patients with fever of unknown origin. With adequate medical therapy, rapid and complete recovery can be expected.

Topics: Animals; Brucellosis; Dogs; Drug Therapy, Combination; Female; Fever of Unknown Origin; Humans; Middle Aged; Streptomycin; Tetracycline; Zoonoses

Topics: Animals; Diagnosis, Differential; Female; Humans; Hydrocortisone; Leptospira interrogans; Leptospirosis; Male; Occupational Diseases; Penicillin G; Tetracycline; Veterinary Medicine; Zoonoses

Topics: Adult; Animals; California; Cats; Child; Female; Humans; Occupational Diseases; Plague; Pneumonia; Pregnancy; Tetracycline; Veterinary Medicine; Zoonoses

Topics: Adult; Animals; Cats; Child; Female; Humans; Occupational Diseases; Plague; Pneumonia; Pregnancy; Tetracycline; Veterinary Medicine; Zoonoses

Topics: Adolescent; Adult; Aged; Animals; Brucellosis; Cats; Colorado Tick Fever; Dogs; Female; Humans; Leptospirosis; Male; Michigan; Middle Aged; Pasteurella Infections; Penicillins; Pregnancy; Psittacosis; Pyrimethamine; Relapsing Fever; Tetracycline; Toxoplasmosis; Zoonoses

A Salmonella heidelberg epidemic in a hospital nursery was traced to infected calves on a dairy farm where the mother of the index patient lived. The Salmonella isolates from all cases were resistant to chloramphenicol, sulfamethoxazole, and tetracycline. Verification of the spread of infection from the farm animals to a hospital population is unusual and raises questions about the hazards of antibiotic animal-feed preparations that may induce infection with resistant organisms in humans.

Topics: Animals; Cattle; Cattle Diseases; Chloramphenicol; Connecticut; Cross Infection; Disease Outbreaks; Drug Resistance, Microbial; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Nurseries, Hospital; Pregnancy; Salmonella; Salmonella Infections; Salmonella Infections, Animal; Sulfamethoxazole; Tetracycline; Zoonoses

Q fever is endemic throughout much of Australia and is most frequently seen in abattoir workers, farmers and veterinarians. Initially, there is a febrile, influenza-like illness. The infection is usually self-limited within several weeks, but rarely patients may develop infective endocarditis or hepatitis. The diagnosis is usually confirmed by finding risings titres of antibodies specific for C. burneti. The infection is not very responsive to treatment, but if tetracycline is administered early, the duration of fever is shortened.

Topics: Abattoirs; Animals; Australia; Complement Fixation Tests; Coxiella; Humans; Mice; Q Fever; Tetracycline; Zoonoses

Topics: Adult; Animals; Antigens; Blood Chemical Analysis; Diagnosis, Differential; Hepatitis A; Humans; Leptospira; Leptospirosis; Male; Tetracycline; Vietnam; Zoonoses

Topics: Animals; Brucellosis; Brucellosis, Bovine; Cattle; Doxycycline; Humans; Male; Protective Clothing; Tetracycline; Zoonoses

The antibiotic resistance patterns of coliforms in faecal specimens from pigs and their human contacts were studied. The ability of the resistant coliforms to transfer their resistance in vitro to antibiotic-sensitive recipients was examined. The results showed that pigs which had received antibiotics carried more multiply-resistant, R-factor bearing coliforms than pigs which had not been given antibiotics. Human contacts of the antibiotic-treated pigs had a higher incidence of antibiotic-resistant coliforms with R-factors than human contacts of pigs which had not been given antibiotics. It is concluded that antibiotic treatment of farm animals may lead to acquisition of antibiotic resistance by gut coliforms of man.

Topics: Ampicillin; Animals; Chloramphenicol; Disease Reservoirs; Extrachromosomal Inheritance; Feces; Humans; Penicillin Resistance; Streptomycin; Sulfonamides; Swine; Swine Diseases; Tetracycline; Zoonoses

Topics: Acetaminophen; Animals; Aspirin; Cattle; Coxiella; Disease Reservoirs; Feces; Fever; Headache; Humans; Milk; Occupational Diseases; Placenta; Q Fever; Radiography, Thoracic; Sheep; Tetracycline; Urine; Zoonoses

Topics: Adolescent; Adult; Aged; Animals; Birds; Complement Fixation Tests; Cough; England; Female; Humans; Male; Middle Aged; Psittacosis; Radiography; Seasons; Sex Factors; Tetracycline; Zoonoses

Topics: Abattoirs; Agricultural Workers' Diseases; Animals; Brucellosis, Bovine; Cattle; Dairying; Female; Germany, East; Humans; Male; Occupational Diseases; Streptomycin; Tetracycline; Veterinary Medicine; Zoonoses

Topics: Animals; Cephalothin; Dog Diseases; Dogs; Endocarditis, Bacterial; Female; Haemophilus; Haemophilus Infections; Heart Valve Prosthesis; Humans; Middle Aged; Mitral Valve; Tetracycline; Zoonoses

Topics: Administration, Oral; Adult; Animals; Folklore; Humans; Injections, Intramuscular; Male; Plague; Streptomycin; Sulfates; Tetracycline; Yersinia pestis; Zoonoses

Topics: Animals; Antibody Formation; Dog Diseases; Dogs; Female; Humans; Immunosuppressive Agents; Male; Mycoplasma; Mycoplasma Infections; Pharynx; Tetracycline; Uterine Cervical Neoplasms; Zoonoses

Topics: Ampicillin; Animals; Chloramphenicol; Disease Outbreaks; Female; Fetal Diseases; Food Microbiology; Germany, East; Humans; Infant, Newborn; Infant, Newborn, Diseases; Listeriosis; Maternal-Fetal Exchange; Meat; Penicillins; Pregnancy; Pregnancy Complications, Infectious; Retrospective Studies; Rural Health; Sheep; Sheep Diseases; Soil Microbiology; Tetracycline; Water Microbiology; Zoonoses

Topics: Adolescent; Adult; Age Factors; Aged; Ampicillin; Animals; Child; Child, Preschool; Chloramphenicol; Diagnosis, Differential; Female; Germany, West; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Listeria monocytogenes; Listeriosis; Male; Middle Aged; Pregnancy; Pregnancy Complications, Infectious; Serologic Tests; Serotyping; Tetracycline; Zoonoses

Topics: Adult; Animals; Brucella; Brucellosis; Disease Outbreaks; Dog Diseases; Dogs; Female; Humans; Immunoglobulins; Inuit; Leukocytes; Lymphoid Tissue; Male; Middle Aged; Mononuclear Phagocyte System; Reindeer; Skin Tests; Species Specificity; Tetracycline; Zoonoses

Topics: Adult; Animals; Cat Diseases; Cats; Chlamydia; Chlamydia Infections; Conjunctiva; Conjunctivitis; Humans; Keratoconjunctivitis; Male; Pneumonia; Tetracycline; Zoonoses

Topics: Adult; Age Factors; Animals; Child; Child, Preschool; Chloramphenicol; Complement Fixation Tests; Diagnosis, Differential; Dogs; Female; Fluorescent Antibody Technique; Hemagglutination Tests; Humans; Insect Bites and Stings; Leukocyte Count; Male; Massachusetts; Measles; Occupations; Rocky Mountain Spotted Fever; Seasons; Tetracycline; Thrombocytopenia; Ticks; Zoonoses

Topics: Adolescent; Adult; Aged; Animals; Child; Disease Outbreaks; Disease Vectors; Female; Fluorescent Antibody Technique; Francisella tularensis; Hemagglutination Tests; Humans; Lymphadenitis; Male; Middle Aged; Penicillins; Rodentia; Skin Ulcer; Streptomycin; Tetracycline; Tularemia; Vermont; Water Pollution; Zoonoses

Topics: Adult; Aged; Animals; Bites and Stings; Child; Child, Preschool; Chloramphenicol; Disease Reservoirs; Erythromycin; Female; Humans; Lung Diseases; Male; Middle Aged; Osteomyelitis; Pasteurella Infections; Penicillin G; Penicillin V; Penicillins; Tetracycline; Ulcer; Wound Infection; Zoonoses

Topics: Adolescent; Adult; Age Factors; Agglutination Tests; Animals; Antibodies; Child; Child, Preschool; Czechoslovakia; Diagnosis, Differential; Female; Humans; Immunodiffusion; Male; Middle Aged; Pasteurella Infections; Seasons; Tetracycline; Zoonoses

Topics: Adult; Animals; Cat Diseases; Cats; Chlamydia; Chlamydia Infections; Conjunctiva; Conjunctivitis; Drug Resistance, Microbial; Humans; Male; Pneumonia; Tetracycline; Zoonoses

Topics: Adult; Animals; Child; Female; Hepatitis; Humans; Male; Meningoencephalitis; Middle Aged; Myocarditis; Psittaciformes; Psittacosis; Respiratory Tract Infections; Tetracycline; Zoonoses

Topics: Adolescent; Animals; Antibodies; Conjunctivitis; Gingiva; Gingivitis, Necrotizing Ulcerative; Humans; Lip; Male; Mycoplasma Infections; Oral Manifestations; Stevens-Johnson Syndrome; Stomatitis, Aphthous; Tetracycline; Zoonoses

Topics: Adult; Animals; Diagnosis, Differential; Echinococcosis, Hepatic; Echinococcus; Female; Hepatectomy; Humans; Laparotomy; Liver Neoplasms; Tetracycline; Thymol; Zoonoses

Topics: Adult; Animal Feed; Animals; Complement Fixation Tests; Diagnosis, Differential; Encephalitis; Female; Germany, West; Humans; Legislation, Medical; Male; Middle Aged; Pneumonia, Viral; Psittaciformes; Psittacosis; Sputum; Tetracycline; Zoonoses

Topics: Animals; Animals, Domestic; Anti-Bacterial Agents; Bacillus; Bacteriological Techniques; Biochemical Phenomena; Biochemistry; Child; Chloramphenicol; Disease Outbreaks; Drug Resistance; Drug Resistance, Microbial; Dysentery; Dysentery, Bacillary; England; Epidemiology; Furazolidone; Haplorhini; Humans; Immunochemistry; Serologic Tests; Streptomycin; Tetracycline; Zoonoses

Topics: Animals; Anti-Bacterial Agents; Bird Diseases; Birds; Chloramphenicol; Columbidae; Complement Fixation Tests; Drug Therapy; Humans; Parakeets; Penicillins; Protein Synthesis Inhibitors; Psittacosis; Tetracycline; Wisconsin; Zoonoses

Topics: Animals; Anti-Bacterial Agents; Bird Diseases; Birds; Humans; Male; New York; Occupational Diseases; Protein Synthesis Inhibitors; Psittacosis; Statistics as Topic; Tetracycline; Zoonoses

Topics: Amphotericin B; Animals; Anthrax; Anti-Bacterial Agents; Child; Communicable Disease Control; Epidemiology; Erythromycin; Ethylenediamines; Humans; Massachusetts; Occupational Diseases; Penicillin G; Penicillin G Benzathine; Penicillin G Procaine; Penicillins; Polymyxins; Procaine; Tetracycline; Textile Industry; Vaccination; Wool; Zoonoses

Topics: Animals; Brucellosis; Calcification, Physiologic; Cattle; Cattle Diseases; Host-Parasite Interactions; Humans; Liver Abscess; Liver Cirrhosis; Occupational Diseases; Pathology; Spleen; Splenectomy; Suppuration; Tetracycline; Zoonoses

Topics: Abscess; Animals; Anti-Bacterial Agents; Appendectomy; Appendicitis; Child; Humans; Lymph Nodes; Lymphadenitis; Mice; Pasteurella Infections; Penicillins; Skin Tests; Streptomycin; Surgical Procedures, Operative; Tetracycline; Zoonoses

Topics: Animals; Anti-Bacterial Agents; Chlortetracycline; Communicable Disease Control; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Listeriosis; Oxytetracycline; Penicillins; Pregnancy; Pregnancy Complications; Pregnancy Complications, Infectious; Sulfonamides; Tetracycline; Zoonoses

Topics: Agglutination; Animals; Anti-Bacterial Agents; Arthropod Vectors; Chloramphenicol; Dihydrostreptomycin Sulfate; Epidemiology; Finland; Mice; Protein Synthesis Inhibitors; Rabbits; Skin Tests; Streptomycin; Tetracycline; Ticks; Tularemia; Zoonoses

Topics: Animals; Anti-Bacterial Agents; Arthritis; Drug Therapy; Finger Injuries; Fingers; Humans; Occupational Diseases; Oxytetracycline; Surgical Procedures, Operative; Tetracycline; Zoonoses

Topics: Animals; Anti-Bacterial Agents; Chloramphenicol; Epidemiology; Female; Fetal Diseases; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Listeria monocytogenes; Listeriosis; Penicillins; Pregnancy; Pregnancy Complications, Infectious; Streptomycin; Sulfonamides; Tetracycline; Washington; Zoonoses

In Canada, about 100 sporadically occurring cases of brucellosis are reported yearly. Three patients were admitted to one Montreal hospital in the first seven months of 1963; all were employed in or around a packing plant. One had pain and electrocardiographic changes suggestive of Brucella myocarditis; he recovered promptly. Symptoms of neurasthenia and anxiety are common and were observed in two of these three cases. Two had positive blood cultures; the third showed conclusive agglutination to Br. abortus (1:10,240). In some patients with frequent previous exposures to infection the agglutination response may be equivocal and difficult to interpret. All three patients responded well to tetracycline; streptomycin and corticosteroids also have a role in the therapy of some cases. There may also be some place for combined antibiotic and vaccine therapy. The program of control of the disease in cattle in Canada is aimed at eradication by 1967.

Topics: Animals; Anti-Bacterial Agents; Antigen-Antibody Reactions; Aspartate Aminotransferases; Brucella; Brucella abortus; Brucellosis; Canada; Cattle; Demeclocycline; Drug Therapy; Electrocardiography; Epidemiology; Hospitals, Veterans; Humans; Male; Meat-Packing Industry; Myocarditis; Occupational Diseases; Pain; Streptomycin; Tetracycline; United States; Veterans; Zoonoses

Topics: Animals; Anti-Bacterial Agents; Chloramphenicol; Czechoslovakia; Drug Therapy; Lagomorpha; Mice; Protein Synthesis Inhibitors; Rabbits; Streptomycin; Tetracycline; Tularemia; Zoonoses