tetracycline and Vascular-Diseases

Scattered qualitative studies in the literature suggest that the reticuloendothelial system (RES) interacts with the microcirculation to effect host defense and that chemical or pharmacologic blockade of the RES might compromise the microcirculation. With this possibility in mind, we designed experiments in rats to determine whether colloid and pharmacologic blockade of the RES could alter microvascular tone and reactivity. The effects of colloidal carbon, thorium dioxide, tripalmitin and tetracycline on reticuloendothelial system phagocytic function, mesenteric terminal arteriolar tone and arteriolar reactivity to noradrenaline and acetylcholine were examined in situ at magnifications up to 5000x. Colloidal carbon and thorium dioxide, in the doses utilized, produced complete blockade of the RES. Treatment with tripalmitin and tetracycline produced pronounced RES depression. RES blockade and depression were associated with marked reductions in terminal arteriolar lumen sizes, curtailment of capillary inflow and outflow, hyper-reactivity to the constrictor, noradrenaline, and hypo-reactivity to the dilator, acetylcholine. Close examination of the endothelial linings of the capillaries, postcapillary venules and terminal arterioles of the experimentally-treated animals indicated pronounced uptake of carbon particles in the endothelial cells, different degrees of endothelial cell swelling and often bulging into the microvessel lumens. Our findings suggest that RES-induced alterations in microvascular tone and arteriolar reactivity may be related to injury of the microvascular endothelial cells.

Topics: Animals; Arteries; Arterioles; Carbon; Endothelium; Male; Mononuclear Phagocyte System; Phagocytosis; Rats; Rats, Inbred Strains; Spasm; Tetracycline; Thorium Dioxide; Triglycerides; Vascular Diseases; Vasoconstriction

Topics: Adolescent; Adult; Aged; Bacteroides Infections; Child; Child, Preschool; Digestive System; Drug Resistance, Microbial; Female; Fusobacterium; Georgia; Humans; Infant; Male; Middle Aged; Neoplasms; Sepsis; Sulfonamides; Tetracycline; Vascular Diseases

Topics: Anemia; Brain Diseases; Craniocerebral Trauma; Endocrine System Diseases; Female; Humans; Hypertension; Intracranial Pressure; Jugular Veins; Mastoiditis; Nalidixic Acid; Pregnancy; Radiography; Steroids; Tetracycline; Vascular Diseases; Veins; Vitamin A; Wiskott-Aldrich Syndrome

Topics: Arteries; Exercise Therapy; Humans; Leg; Prognosis; Tetracycline; Vascular Diseases

A fatal case of Listeria monocytogenes septicaemia and encephalitis is described. The infection was associated with steroid therapy given for necrotizing cutaneous vasculitis. Agglutinating antibodies were not detectable in the patient's serum. Reasons for the failure of apparently appropriate antibiotic therapy are discussed.

Topics: Aged; Agglutination Tests; Ampicillin; Encephalitis; Female; Humans; Listeriosis; Prednisone; Sepsis; Tetracycline; Vascular Diseases

Topics: Animals; Cecum; Chlortetracycline; Colon, Sigmoid; Cricetinae; Diarrhea; Drug Hypersensitivity; Epithelium; Intestine, Large; Necrosis; Oxytetracycline; Tetracycline; Vascular Diseases

Topics: Abscess; Ampicillin; Cephalothin; Chloramphenicol; Enterobacter; Escherichia coli; Haemophilus influenzae; Humans; Imidazoles; Infections; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillin G; Penicillins; Peritoneal Diseases; Proteus; Pseudomonas aeruginosa; Respiratory Tract Infections; Sepsis; Staphylococcus; Streptococcus; Streptococcus pneumoniae; Surgical Wound Infection; Tetracycline; Urinary Tract Infections; Vascular Diseases; Wound Infection

Topics: Acute Disease; Aged; Bromelains; Chloramphenicol; Female; Humans; Male; Middle Aged; Tetracycline; Vascular Diseases; Veins

Topics: Ascites; Blood Protein Electrophoresis; Folic Acid; Humans; Liver Cirrhosis; Portal System; Splenectomy; Testosterone; Tetracycline; Thiamine; Urine; Vascular Diseases; Vitamin B Complex

Topics: Anterior Spinal Artery Syndrome; Anti-Bacterial Agents; Antibiotics, Antitubercular; Anuria; Arteries; Constipation; Humans; Neurologic Manifestations; Penicillins; Spine; Sulfonamides; Syphilis; Syphilis, Cardiovascular; Tetracycline; Vascular Diseases

Topics: Anti-Bacterial Agents; Humans; Hypertension; Pyelonephritis; Tetracycline; Vascular Diseases

Topics: Humans; Injections; Lower Extremity; Peripheral Vascular Diseases; Sciatic Nerve; Sciatic Neuropathy; Tetracycline; Vascular Diseases

Topics: Anti-Bacterial Agents; Humans; Hypersensitivity; Protein Synthesis Inhibitors; Tetracycline; Vascular Diseases