tetracycline and Uterine-Cervicitis

Topics: 4-Quinolones; Anti-Infective Agents; Cephalosporins; Conjunctivitis, Bacterial; Female; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Penicillin G; Tetracycline; Urethritis; Uterine Cervicitis

We evaluated the effect of treatment of gonorrhea on simultaneous Chlamydia trachomatis infection by randomly assigning 293 heterosexual men and 246 heterosexual women with gonorrhea to receive one of the following treatment regimens: (1) 4.8 million units of aqueous procaine penicillin plus 1 g of probenecid, (2) nine tablets of trimethoprim-sulfamethoxazole daily for three days, or (3) 500 mg of tetracycline four times a day for five days. Among the men, gonococcal infection was cured in 99 per cent given penicillin plus probenecid, 96 per cent given trimethoprim-sulfamethoxazole, and 98 per cent given tetracycline. Among the women, only 90 per cent given tetracycline were cured, in contrast to 97 per cent given penicillin plus probenecid and 99 per cent given trimethoprim-sulfamethoxazole. Chlamydial infection, present in 15 per cent of the men and 26 per cent of the women, was cured in 30 of 32 patients given trimethoprim-sulfamethoxazole and 27 of 29 given tetracycline, but in only 10 of 23 given penicillin plus probenecid. Among chlamydia-positive patients, postgonococcal urethritis in men and cervicitis in women occurred more often in patients given penicillin plus probenecid. Salpingitis developed in 6 of 20 women given penicillin plus probenecid, but in only 1 of 26 given trimethoprim-sulfamethoxazole and in none of 24 given tetracycline. We conclude that the use of penicillin plus probenecid alone for gonorrhea in heterosexual patients carries an unacceptably high risk of postgonococcal chlamydial morbidity. Trimethoprim-sulfamethoxazole and tetracycline were highly effective against both pathogens and were well tolerated in men, but both drugs caused frequent side effects in women. The failure of tetracycline to cure gonorrhea in 10 per cent of women argues against its use alone; treatment with penicillin followed by tetracycline has been recommended for further trial.

Topics: Adolescent; Clinical Trials as Topic; Drug Administration Schedule; Drug Combinations; Female; Gonorrhea; Humans; Lymphogranuloma Venereum; Male; Pelvic Inflammatory Disease; Penicillin G Procaine; Probenecid; Random Allocation; Sex Factors; Sulfamethoxazole; Tetracycline; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Urethritis; Uterine Cervicitis

One hundred thirteen women had Chlamydia trachomatis isolated from the cervix, or urethra, or both, were treated, and followed until failure occurred or for at least 40 days after initiation of treatment. On regimens given four times daily for 7 days, failure occurred in three (8%) of 38 on tetracycline, 500 mg, in none of five on erythromycin, 500 mg, and in three (8%) of 37 on erythromycin, 250 mg. On regimens of 500 mg given four times daily for 10 days, failure occurred in none of nine on tetracycline and in one (4%) of 24 on sulfisoxazole. Erythromycin, 500 mg, was stopped because of severe side effects. Another 10 women were given a loading dose of ampicillin plus additional ampicillin for 3 to 21 days and were followed for 4 to 76 days after treatment was stopped. Only two women remained culture positive after therapy. This study demonstrates that antimicrobial regimens that are frequently given to women in North America have significant activity against C. trachomatis.

Topics: Anti-Bacterial Agents; Chlamydia Infections; Chlamydia trachomatis; Erythromycin; Female; Humans; Random Allocation; Sulfisoxazole; Tetracycline; Urethritis; Uterine Cervicitis

Haemophilus somnus was consistently isolated from vaginal discharges of dairy cows submitted from field cases of vaginitis, cervicitis and/or metritis in the KwaZulu-Natal Midlands during the period July 1995 - December 2000 and from the East Griqualand area in November/December 2000. The purulent vaginal discharges, red granular vaginitis and cervicitis, and pain on palpation described in these cases was very similar to that reported in outbreaks of H.somnus endometritis syndrome in Australia, Europe and North America. In all the herds involved in these outbreaks, natural breeding with bulls was employed. Although there was a good cure rate in clinically-affected animals treated with tetracyclines, culling rates for chronic infertility were unacceptably high. Employment of artificial insemination in these herds improved pregnancy rates in cows that had calved previously, but many cows that had formerly been infected failed to conceive.

Topics: Animals; Breeding; Cattle; Cattle Diseases; Disease Outbreaks; Endometritis; Female; Haemophilus; Haemophilus Infections; Infertility, Female; Insemination, Artificial; Male; Pregnancy; Pregnancy Rate; South Africa; Syndrome; Tetracycline; Uterine Cervicitis; Vaginitis

To study the prevalence of Chlamydia trachomatis (CT) and Ureaplasma urealyticum (Uu) cervical infection in infertility women, and therapeutic effectiveness of tetracycline and qianglimycin.. CT in cervical swab specimen was detected by cell culture, polymerase chain reaction(PCR) and immunofluorescent assay(IFA), Uu in cervical swab specimen was detected by culture, in a group of 145 infertility women, before and after treatment, and 45 women at productive age who attended obstetric and gynecologic clinic.. The positive rate of CT by cell culture, PCR, IFA(shell) and IFA(direct smear) was 62.7%, 66.8%, 64.8% and 36.5%, respectively, which was obviously higher than that of the control (P < 0.01). The positive rate of Uu was 33.1%, that of CT and Uu co-infection was 18.6%. Both were obviously higher than those of the control (P < 0.01).. This study indicates that the prevalence of CT and Uu cervical infection in infertility women is high. CT and Uu cervical infection is closely related to female infertility. The therapeutic effectiveness of tetracycline and qianglimycin is not ideal.

Topics: Adult; Anti-Bacterial Agents; China; Chlamydia Infections; Chlamydia trachomatis; Female; Humans; Infertility, Female; Prevalence; Tetracycline; Ureaplasma Infections; Ureaplasma urealyticum; Uterine Cervicitis

To assess the effects of antibiotic treatment of urethritis or cervicitis on the incidence of recurrences of articular symptoms in Reiter's syndrome patients.. Retrospective evaluation of the medical charts of 109 patients living in Greenland.. Thirty-seven percent of the episodes of genitourinary tract inflammation that were not treated or were treated with penicillin were followed by arthritis, compared with 10% of those treated with tetracycline or erythromycin.. Antibiotics active against Chlamydia trachomatis reduced the risk of postvenereal arthritis in the population studied.

Topics: Adult; Arthritis; Arthritis, Reactive; Erythromycin; Female; Greenland; Humans; Incidence; Inuit; Male; Penicillins; Recurrence; Retrospective Studies; Sexually Transmitted Diseases; Tetracycline; Urethritis; Uterine Cervicitis

A study was performed on 321 patients with paratrachoma: acute follicular conjunctivitis-189, subacute-132. The first group of patients (108) received 1% Tetracycline ointment 4 to 5 times daily, the second group (103 patients)-1% Tetracycline ointment + 0.1% Dexamethasone eye drops, the third group (110 patients)-Eubetal ointment (tetracycline 0.5%, betamethasone 0.1%, chloramphenicol 1%, colistin). Therapeutic efficacy was higher in groups were antibiotics combined with corticosteroids. Cured in 4 weeks in group I-46.3%, in group II-72.8%, in group III-71.8%, cured in 6 weeks-75.9%, 88.3% and 86.4% respectively.

Topics: Acute Disease; Administration, Topical; Adolescent; Adult; Betamethasone; Chlamydia Infections; Chloramphenicol; Colistin; Conjunctivitis, Inclusion; Dexamethasone; Drug Combinations; Drug Therapy, Combination; Female; Humans; Male; Ointments; Ophthalmic Solutions; Tetracycline; Treatment Outcome; Urethritis; Uterine Cervicitis

Four cases of Chlamydia infection of the urogenital tract were received-recently in our out-patient clinic for foreign patients. The 4 patients were two couples. Both male patients had histories of coitus with other partners: among these two, one had suffered gonorrhea and the other was suspected of having had gonorrhea. Urogenital tract symptoms or sustained abnormal urine analysis results are characteristic of this disease, but in females often no obvious symptoms present. Measurements with fluorescence-labeled Chlamydia trachomatis monoclonal antibody provided a simple and accurate method and was used in the diagnosis of this disease. All the 4 cases were cured by tetracycline. Finally, current epidemics, infectious features, diagnosis and treatment for this disease are discussed.

Topics: Adult; Chlamydia Infections; Chlamydia trachomatis; Female; Humans; Male; Tetracycline; Urethritis; Uterine Cervicitis

Topics: Chlamydia Infections; Female; Humans; Tetracycline; Uterine Cervicitis; Vaginal Smears

Convenient, reliable tests of cure for genital chlamydial infections have not been evaluated. Cervical appearance, endocervical Gram stain, enzyme immunoassay, and culture for Chlamydia trachomatis were evaluated during a pretreatment visit and at two subsequent randomized test-of-cure visits for 64 nongravid women with endocervical C trachomatis of 3544 patients screened. There were no useful correlations between C trachomatis resolution and cervical appearance. Endocervical Gram stain was determined to be unreliable for test-of-cure use. Both C trachomatis culture and enzyme-linked immunosorbent assay (ELISA) were shown to be effective for test-of-cure evaluation. The ELISA test became reliably negative 10 days after initiation of treatment and 1 to 5 days after the clearance of viable organisms detected by culture (P = .03). Convenience and cost considerations favor antigen detection methods. This study suggests that antigen detection methods can be used for situations in which test of cure is indicated, such as therapy noncompliance, circumstances supporting reinfection, pregnancy, complicated infections, requests for psychological reassurance, and evidence of persistent cervicitis.

Topics: Chlamydia Infections; Chlamydia trachomatis; Enzyme-Linked Immunosorbent Assay; Female; Humans; Tetracycline; Uterine Cervicitis

Cervical Chlamydia trachomatis infection is extremely common, crucial and sexually transmitted disease. In order to prevent from this disease an effective treatment is necessary. Tetracycline is an effective antimicrobial medicine for treatment of cervical Chlamydia trachomatis infection. In our study, after we had established the diagnosis of Chlamydia trachomatis on the patient's cervical smear, Tetracycline was used for treatment. In control smear after treatment. Chlamydial intracytoplasmic inclusion bodies and atypical cellular changes which we observed in the first smear were not seen.

Topics: Chlamydia Infections; Chlamydia trachomatis; Female; Humans; Tetracycline; Uterine Cervicitis; Vaginal Smears

Three treatment regimens are currently recommended for penicillin-susceptible Neisseria gonorrhoeae infection of the cervix: ampicillin, tetracycline, and a combination of ampicillin and tetracycline. To evaluate the cost-effectiveness of these options, we developed a decision analysis model and analyzed the efficacy of each treatment in curing gonorrhea, as well as coexisting Chlamydia trachomatis infection, and in preventing subsequent pelvic inflammatory disease, ectopic pregnancy, and infertility. We included direct costs of medication and expenditures for management of unresolved infections and associated complications. Combination treatment is more than twice as cost-effective as tetracycline and seven times as cost-effective as ampicillin when the medical cost of managing pelvic inflammatory disease is considered. When the costs of ectopic pregnancies and infertility are included, the cost-effectiveness of combination treatment increases further.

Topics: Ampicillin; Chlamydia Infections; Chlamydia trachomatis; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Gonorrhea; Humans; Infertility, Female; Pelvic Inflammatory Disease; Pregnancy; Pregnancy, Ectopic; Tetracycline; Uterine Cervicitis

Topics: Chlamydia Infections; Chlamydia trachomatis; Endometritis; Female; Genital Diseases, Female; Humans; Pregnancy; Pregnancy Complications, Infectious; Salpingitis; Tetracycline; Urethritis; Uterine Cervicitis; Vaginal Smears; Vaginitis

Chlamydia trachomatis causes more sexually transmissible diseases in the United States than any other organism. Complications of chlamydial urethritis and cervicitis include epididymitis, salpingitis and neonatal pneumonia. Chlamydial infections can be easily treated but, until recently, they have been difficult to diagnose. Presumptive antichlamydial therapy for symptomatic/high-risk individuals was the first step taken towards control. With new methods of diagnosis becoming available, detection in asymptomatic women is the next critical step. Key populations for screening include clinics for family planning, abortion, student health, adolescent care and prenatal care. This article outlines the biology, diseases, diagnosis and treatment of C. trachomatis.

Topics: Antibodies, Monoclonal; Chlamydia Infections; Chlamydia trachomatis; Female; Fluoresceins; Humans; Male; Mass Screening; Nurse Practitioners; Pregnancy; Salpingitis; Tetracycline; Urethritis; Uterine Cervicitis

The records of 1,381 patients with gonorrhea were examined by the Massachusetts Department of Public Health to determine the efficacy of their treatment schedules. Urethritis, cervicitis and pharyngitis were treated with 4.8 million u. of aqueous procaine penicillin G intramuscularly, without probenecid. Cure rates were 98 percent in urethritis, 97 percent in pharyngitis and 98 percent in cervicitis. Patients allergic to penicillin were treated with tetracycline orally or spectinomycin intramuscularly. In patients with proctitis, a 98 percent cure rate was achieved with one intramuscular injection of procaine penicillin G, followed by ampicillin orally for four days.

Topics: Adult; Ampicillin; Drug Administration Schedule; Female; Gonorrhea; Humans; Male; Pelvic Inflammatory Disease; Penicillin G Procaine; Penicillin Resistance; Pharyngitis; Proctitis; Spectinomycin; Tetracycline; Urethritis; Uterine Cervicitis

Chlamydiae are obligate intracellular parasites, bacteria with a peculiar biology. They belong to the genus Chlamydia which includes two species: C. psittaci and C. trachomatis. A wide range of hosts, including birds, mammals and man can be infected by chlamydiae. The diseases chlamydiae can produce include psittacosis, lymphogranuloma venereum, trachoma, inclusion conjunctivitis, urethritis, cervicitis, pelvic inflammatory disease, and neonatal pneumonia. The diagnosis of chlamydial infection may be made by visualization of the organism in direct smears, isolation of the agent in cell culture, or by demonstrating a significant rise in antibody titer. Chlamydial infection may be treated with tetracycline, erythromycin, or sulfonamides.

Topics: Adult; Arthritis, Reactive; Child; Chlamydia Infections; Conjunctivitis, Inclusion; Epididymitis; Erythromycin; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lymphogranuloma Venereum; Male; Pelvic Inflammatory Disease; Pneumonia; Sexually Transmitted Diseases; Tetracycline; Trachoma; Urethritis; Uterine Cervicitis

Chlamydia trachomatis is being recognized as an important sexually transmitted disease in adolescents and young adults. This report reviews the recent literature regarding the many clinical entities encompassed by this organism; this includes urethritis and cervicitis as well as epididymitis, salpingitis, peritonitis, perihepatitis, urethral syndrome, Reiter syndrome, arthritis, endocarditis, and others. It is emphasized that many aspects of chlamydial infections parallel those of gonorrhea, including incidence, transmission, carrier state, reservoir, complications, (local and systemic), and others. A paragonococcal spectrum of sexual chlamydial disorders is discussed as well as effective antibiotic therapy. This microbiological agent must always be considered if venereal disease is suspected by the clinician in teenagers or adults. Mixed infections with Chlamydia trachomatis and Neisseria gonorrhoeae are common in both males and females. It may be preferable to treat gonorrhea with tetracycline to cover for this possibility.

Topics: Adolescent; Adult; Chlamydia Infections; Chlamydia trachomatis; Diagnosis, Differential; Female; Gonorrhea; Humans; Male; Sexually Transmitted Diseases; Tetracycline; Urethritis; Uterine Cervicitis

Cervical abnormalities accompanied by Papanicolaou Class II or Class III cytologic results are commonly encountered in gynecologic office practice. Chlamydiae are a common cause of genital tract infection, with or without manifest symptoms or signs. An immunofluorescence method was used to determine the presence of antichlamydial antibodies in cervical secretions. Eleven of 15 patients in whom such antibodies were found (73.3%) had Papanicolaou Class II or Class III smears, in contrast to only 3 of 18 patients (16.7%) without antichlamydial antibodies. The determination of antichlamydial antibodies in cervical mucus was highly reproducible, and specimens were readily collected in the office, without the need of prompt laboratory procedures. In selected patients, tetracycline treatment of early chlamydial infection resulted both in the disappearance of the antibody from cervical secretions and in the reversion of the Papanicolaou smear from Class II or Class III to Class I.

Topics: Adult; Antibodies, Bacterial; Cervix Uteri; Chlamydia Infections; Chlamydia trachomatis; Chlamydophila psittaci; Female; Humans; Papanicolaou Test; Tetracycline; Uterine Cervicitis; Vaginal Smears

The effect of minocycline on nongonococcal urethritis (NGU) was investigated, with particular reference to its action against Chlamydia trachomatis. Preliminary laboratory studies showed that the drug was active against a laboratory chlamydial strain (Lb4f) in vitro. A group of 133 men with first attacks of NGU was then treated with minocycline, 100 mg twice daily for 3 weeks. Isolates of C trachomatis were obtained from 33 of these men before treatment; all of them gave negative results on cell culture after therapy. Of the 133 patients, 119 (90%) had symptoms on their first attendance, but after one week's treatment only 16 of the 133 (12%) and after 3 weeks 6 of the 133 (5%) had symptoms. All 133 men had demonstrable urethritis initially; by the end of the first week of treatment only 43 of the 133 (32%) and by the end of the third week 32 of the 133 (24%) had evidence of urethritis. There were no differences in clinical response between the Chlamydia-positive and Chlamydia-negative groups. A group of 24 female sexual contacts of men with NGU yielded C trachomatis on cell culture. After 3 weeks' therapy with minocycline all these women gave negative results on cell culture. It is concluded that minocycline is a useful addition to existing remedies for NGU. The future structure of treatment trials for NGU is discussed.

Topics: Animals; Chick Embryo; Chlamydia; Chlamydia Infections; Chlamydia trachomatis; Drug Evaluation; Female; Humans; Male; Minocycline; Tetracycline; Tetracyclines; Urethritis; Uterine Cervicitis

Topics: Adolescent; Adult; Chronic Disease; Drug Combinations; Drug Therapy, Combination; Female; Gonorrhea; Humans; Immunotherapy; Middle Aged; Oleandomycin; Pelvic Inflammatory Disease; Prodigiosin; Tetracycline; Trichomonas Infections; Urethritis; Uterine Cervicitis

Topics: Chlamydia Infections; Female; Granuloma Inguinale; Humans; Lymphogranuloma Venereum; Male; Mycoplasma Infections; Proctitis; Sexually Transmitted Diseases; Tetracycline; Urethritis; Uterine Cervicitis; Vaginitis

Topics: Arthritis, Reactive; Chlamydia; Chlamydia Infections; Conjunctivitis, Inclusion; Female; Humans; Male; Sulfonamides; Tetracycline; Trachoma; United Kingdom; Urethritis; Uterine Cervicitis

Topics: Adolescent; Adult; Chymotrypsin; Female; Guaifenesin; Humans; Male; Middle Aged; Pelvic Inflammatory Disease; Respiratory Tract Infections; Tetracycline; Trypsin; Uterine Cervicitis

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Female; Fertility; Humans; Infertility; Infertility, Male; Male; Pelvic Inflammatory Disease; Penicillins; Protein Synthesis Inhibitors; Spermatozoa; Streptomycin; Tetracycline; Uterine Cervicitis