tetracycline and Uterine-Cervical-Neoplasms

To investigate whether the use of an antibacterial vaginal pessary containing tetracycline and amphotericin B would reduce complications from large loop excision of the transformation zone (LLETZ).. Prospective randomised controlled trial.. Department of Obstetrics and Gynaecology, University of Hong Kong.. A total of 321 women who underwent LLETZ.. Women were randomised to either receiving an antimicrobial vaginal pessary twice a day for 14 days after LLETZ or no medication. Before LLETZ, endocervical and high vaginal swabs were taken for the detection of Chlamydia and other pathogens. All women were given a diary to record the degree of symptoms, such as vaginal discharge, bleeding and pain for 3 weeks. These were then compared between the two groups.. Bleeding, vaginal discharge and pain after LLETZ.. There was no significant difference in the total bleeding, vaginal discharge and pain scores between the two groups. However, for women who had positive endocervical or high vaginal swabs, the treatment group had significantly less bleeding in the second week (Z=-2.083, P= 0.037) and less overall vaginal discharge (Z=-2.024, P= 0.043).. An antimicrobial vaginal pessary containing tetracycline and amphotericin B did not provide any significant benefit after LLETZ, except for a subgroup of women with positive vaginal or endocervical swabs. Given that this group of women cannot be identified before the procedure since swabs are not routinely taken, the use of routine prophylactic topical antibiotics cannot be recommended for the general population.

Topics: Abdominal Pain; Administration, Intravaginal; Adult; Amphotericin B; Anti-Bacterial Agents; Antibiotic Prophylaxis; Chlamydia Infections; Female; Humans; Pessaries; Postoperative Complications; Prospective Studies; Tetracycline; Treatment Failure; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms; Uterine Hemorrhage; Vaginal Discharge

Topics: Cautery; Cervix Mucus; Clinical Trials as Topic; Colposcopy; Female; Follow-Up Studies; Humans; Neoplasm Regression, Spontaneous; Placebos; Suppositories; Tetracycline; Time Factors; Uterine Cervical Neoplasms; Vaginal Smears

Pelvic lymphocysts developed in 3 of 124 patients undergoing radical surgery for cervical cancer. All were managed by percutaneous aspiration under local anesthesia in an outpatient setting. Sclerosis was required in one patient. This management plan is superior to laparotomy in being less morbid and equally effective.

Topics: Adenocarcinoma; Adult; Anesthesia, Local; Drainage; Female; Humans; Hysterectomy; In Vitro Techniques; Lymphatic Diseases; Lymphocele; Middle Aged; Postoperative Complications; Tetracycline; Uterine Cervical Neoplasms

A group of 1760 women aged 14-35 years were examined for the concurrent presence of Chlamydia trachomatis and cellular atypia of cervical smears. Positive tests for C trachomatis were found in 126 women (7.2%). Cell changes were found in 85 women (4.8%), and 25 of these were C trachomatis-positive. Slight cellular atypia was the major finding in the smears from 22 of the C trachomatis-positive women, whereas three patients had more pronounced cell changes. Smears reverted to normal in 18 of the 23 patients who returned for tetracycline treatment and follow-up cytology. All 18 patients had smears showing slight cellular atypia prior to therapy. In five patients who also had cellular changes suggesting a human papillomavirus infection, the smears did not revert to normal after antibiotic therapy during the observation period. These findings suggest that patients with C trachomatis and mild cellular atypia should have antibiotic therapy and repeat smears taken before further treatment is considered. More advanced cellular atypia is unlikely to be caused by C trachomatis.

Topics: Adolescent; Adult; Cervix Uteri; Chlamydia Infections; Chlamydia trachomatis; Female; Humans; Tetracycline; Uterine Cervical Diseases; Uterine Cervical Neoplasms; Vaginal Smears

Topics: Adult; Antineoplastic Agents; Carcinoma in Situ; Female; Humans; Metronidazole; Nystatin; Precancerous Conditions; Rifampin; Tetracycline; Uterine Cervical Neoplasms

Topics: Aged; Carcinoma; Diagnosis, Differential; Female; Granuloma Inguinale; Humans; Streptomycin; Tetracycline; Uterine Cervical Neoplasms

Topics: Animals; Antibody Formation; Dog Diseases; Dogs; Female; Humans; Immunosuppressive Agents; Male; Mycoplasma; Mycoplasma Infections; Pharynx; Tetracycline; Uterine Cervical Neoplasms; Zoonoses

Topics: Boron; Cell Line; Cells, Cultured; Conjunctiva; Endoplasmic Reticulum; Female; HeLa Cells; Humans; Leukemia, Myeloid; Lung; Microscopy, Fluorescence; Neoplasms; Tetracycline; Uterine Cervical Neoplasms

Topics: Acridines; Culture Techniques; Female; Fluorescence; Humans; Tetracycline; Uterine Cervical Diseases; Uterine Cervical Neoplasms

Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Cytodiagnosis; Female; Genital Neoplasms, Female; Humans; Microscopy, Fluorescence; Ovarian Neoplasms; Tetracycline; Uterine Cervical Neoplasms; Uterine Neoplasms; Vulvar Neoplasms

Topics: Anti-Bacterial Agents; Female; Fluorescence; Fluoroscopy; Humans; Neoplasms; Protein Synthesis Inhibitors; Tetracycline; Uterine Cervical Neoplasms

Topics: Animals; Female; Fluorescence; Humans; In Vitro Techniques; Microscopy, Fluorescence; Rats; Sarcoma, Yoshida; Tetracycline; Uterine Cervical Neoplasms

Topics: Alkylating Agents; Antineoplastic Agents; Biomedical Research; Blood Platelets; Bone Marrow; Erythrocyte Count; Female; Humans; Leukocyte Count; Melphalan; Ovarian Neoplasms; Pharmacology; Tetracycline; Toxicology; Uterine Cervical Neoplasms

Topics: Administration, Intravenous; Enteritis; Female; Humans; Hysterectomy; Injections, Intravenous; Nephrosis; Pyelitis; Tetracycline; Toxicology; Uterine Cervical Neoplasms