tetracycline and Urethritis

Topics: 4-Quinolones; Anti-Infective Agents; Cephalosporins; Conjunctivitis, Bacterial; Female; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Penicillin G; Tetracycline; Urethritis; Uterine Cervicitis

The role of Chlamydia trachomatis in infections of the male genital tract is reviewed. The organism is an important cause of non-gonococcal urethritis, post-gonococcal urethritis and epididymitis, but does not appear to play a major part in the pathogenesis of chronic abacterial prostatitis or in proctitis in anoreceptive homosexual men.

Topics: Chlamydia Infections; Chlamydia trachomatis; Epididymitis; Genital Diseases, Male; Humans; Male; Tetracycline; Urethritis

Tetracyclines have an unusually broad spectrum of antimicrobial activity. They are generally well tolerated, with relatively few side effects compared with alternative antibiotic choices. Tetracyclines also compare favorably with newer antimicrobials, i.e., oral quinolones, with respect to cost and microbial resistance. Doxycycline's and minocycline's spectrum of antibacterial activity, pharmacokinetic profile, and safety profile make them preferred drugs when tetracyclines are indicated in urologic infections.

Topics: Bacteria; Female; Gonorrhea; Humans; Intestinal Absorption; Lymphogranuloma Venereum; Male; Prostate; Prostatitis; Pyelonephritis; Tetracycline; Tetracycline Resistance; Tissue Distribution; Urethritis; Urinary Tract Infections

Topics: Anti-Bacterial Agents; Cephalosporins; Chlamydia Infections; Erythromycin; Gonorrhea; Humans; Male; Spectinomycin; Tetracycline; Urethritis

Nongonococcal urethritis is a venereal disease whose incidence is almost double that of gonorrhea. Despite this, the diagnosis, origin, treatment, and complications of nongonococcal urethritis remain unclear. Although some cases are undoubtedly caused by infection with Chlamydia trachomatis, the origin of many cases is uncertain. Treatment is recommended to shorten symptoms and prevent complications. This review presents the current status of this confusing disease.

Topics: Adolescent; Adult; Epididymitis; Female; Gonorrhea; Humans; Infant; Male; Mycoplasma Infections; Neisseria gonorrhoeae; Pelvic Inflammatory Disease; Pneumonia; Sexually Transmitted Diseases; Tetracycline; Trachoma; Urethritis

Topics: Female; Humans; Infant, Newborn; Lymphogranuloma Venereum; Male; Pregnancy; Proctitis; Salpingitis; Tetracycline; Urethritis

Topics: Anti-Bacterial Agents; Carbenicillin; Clindamycin; Diarrhea; Enterocolitis, Pseudomembranous; Erythromycin; Humans; Legionnaires' Disease; Lung Diseases; Male; Methicillin; Penicillin Resistance; Prostatitis; Staphylococcal Infections; Staphylococcus aureus; Streptococcus pneumoniae; Tetracycline; Urethritis; Vancomycin

Topics: Administration, Oral; Arthritis, Reactive; Candida; Chlamydia; Coitus; Culture Media; Epididymitis; Female; Gonorrhea; Humans; Male; Mycoplasma; Neisseria gonorrhoeae; Prostatitis; Recurrence; Tetracycline; Urethral Stricture; Urethritis; Urine

Topics: Ampicillin; Anti-Bacterial Agents; Female; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Penicillin G; Spectinomycin; Sulfonamides; Tetracycline; Urethritis

Topics: Anti-Bacterial Agents; Cephaloridine; Gonorrhea; Humans; Kanamycin; Male; Neisseria gonorrhoeae; Oxytetracycline; Penicillins; Sulfonamides; Tetracycline; Urethritis

Topics: Anti-Bacterial Agents; Chlamydia Infections; Cost-Benefit Analysis; Drug Costs; Humans; Lymecycline; Male; Sweden; Tetracycline; Urethritis

The antibacterial efficacy and tolerability of erythromycin acistrate (EA) and erythromycin stearate (ES) were compared in 100 male patients with non-gonococcal urethritis (NGU). The dosage of EA was 400 mg tid and that of ES 500 mg tid. Mean duration of treatment was ten days. When the final evaluation of the trial was made, the patient material was divided into two groups. One group consisted of patients with chlamydia-positive culture before treatment, the other of chlamydia-negative patients with signs of infection in the direct smear. There were 17 patients with chlamydial infection in the EA-group, and the microbiological cure rate was 100%. In the ES-group there were 21 patients with chlamydial infection and the microbiological cure rate was 95%. In the EA-group, the cure rate of chlamydia-negative NGU patients was 78%, and the corresponding figure in the ES-group was 86%. There was no difference in the cure rates between the two groups on either drug. In the EA-group, 25 patients (50%) reported side effects, in 22 these were gastrointestinal. In the ES-group, 26 patients (52%) reported side effects; in 22 these were gastrointestinal. Two patients in the EA-group discontinued the treatment because of gastrointestinal side effects. There were no differences between the groups in the frequency, severity and duration of side effects.

Topics: Adolescent; Adult; Chlamydia Infections; Erythromycin; Humans; Male; Prodrugs; Tetracycline; Urethritis

We evaluated the effect of treatment of gonorrhea on simultaneous Chlamydia trachomatis infection by randomly assigning 293 heterosexual men and 246 heterosexual women with gonorrhea to receive one of the following treatment regimens: (1) 4.8 million units of aqueous procaine penicillin plus 1 g of probenecid, (2) nine tablets of trimethoprim-sulfamethoxazole daily for three days, or (3) 500 mg of tetracycline four times a day for five days. Among the men, gonococcal infection was cured in 99 per cent given penicillin plus probenecid, 96 per cent given trimethoprim-sulfamethoxazole, and 98 per cent given tetracycline. Among the women, only 90 per cent given tetracycline were cured, in contrast to 97 per cent given penicillin plus probenecid and 99 per cent given trimethoprim-sulfamethoxazole. Chlamydial infection, present in 15 per cent of the men and 26 per cent of the women, was cured in 30 of 32 patients given trimethoprim-sulfamethoxazole and 27 of 29 given tetracycline, but in only 10 of 23 given penicillin plus probenecid. Among chlamydia-positive patients, postgonococcal urethritis in men and cervicitis in women occurred more often in patients given penicillin plus probenecid. Salpingitis developed in 6 of 20 women given penicillin plus probenecid, but in only 1 of 26 given trimethoprim-sulfamethoxazole and in none of 24 given tetracycline. We conclude that the use of penicillin plus probenecid alone for gonorrhea in heterosexual patients carries an unacceptably high risk of postgonococcal chlamydial morbidity. Trimethoprim-sulfamethoxazole and tetracycline were highly effective against both pathogens and were well tolerated in men, but both drugs caused frequent side effects in women. The failure of tetracycline to cure gonorrhea in 10 per cent of women argues against its use alone; treatment with penicillin followed by tetracycline has been recommended for further trial.

Topics: Adolescent; Clinical Trials as Topic; Drug Administration Schedule; Drug Combinations; Female; Gonorrhea; Humans; Lymphogranuloma Venereum; Male; Pelvic Inflammatory Disease; Penicillin G Procaine; Probenecid; Random Allocation; Sex Factors; Sulfamethoxazole; Tetracycline; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Urethritis; Uterine Cervicitis

Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Humans; Leucomycins; Male; Tetracycline; Urethritis

A clinical trial compared the relative efficacy of tetracycline hydrochloride 250 mg qid and minocycline hydrochloride 100 mg bid given for an initial period of ten days to 59 patients suffering from non-gonococcal urethritis (NGU). Those patients with persistent symptoms or signs on completion of the initial course were given a second course for a further ten days at the same dosage. The treatments were equivalent. A significant number of patients not clinically cured after one course of treatment responded satisfactorily to a second course.

Topics: Adolescent; Adult; Drug Evaluation; Humans; Male; Minocycline; New Zealand; Tetracycline; Tetracyclines; Urethritis

The clinical and microbiological outcome of the treatment of 94 men for uncomplicated non-gonococcal urethritis (NGU) was studied. Rosaramicin 250 mg six hourly for seven days was given to 46 men and tetracycline 250 mg six hourly for seven days to 48 men; the follow-up period was up to six weeks. Complete resolution of the clinical signs of infection was seen in 40 (87%) of the men treated with rosaramicin and in 37(77%) of those treated with tetracycline. Chlamydia trachomatis was eliminated from 17 of the 18 men treated with rosaramicin and from all of the 16 men treated with tetracycline. Ureaplasma urealyticum was eliminated from 12 of the 14 men treated with rosaramicin and from 15 of the 19 receiving tetracycline. Clinical recovery correlated well with the elimination of C trachomatis but less well with that of U urealyticum. The two antimicrobial agents were equally effective in the therapy of NGU, but gastrointestinal side effects were significantly more common in men treated with rosaramicin.

Topics: Chlamydia trachomatis; Clinical Trials as Topic; Humans; Leucomycins; Male; Tetracycline; Ureaplasma; Urethritis

One hundred thirteen women had Chlamydia trachomatis isolated from the cervix, or urethra, or both, were treated, and followed until failure occurred or for at least 40 days after initiation of treatment. On regimens given four times daily for 7 days, failure occurred in three (8%) of 38 on tetracycline, 500 mg, in none of five on erythromycin, 500 mg, and in three (8%) of 37 on erythromycin, 250 mg. On regimens of 500 mg given four times daily for 10 days, failure occurred in none of nine on tetracycline and in one (4%) of 24 on sulfisoxazole. Erythromycin, 500 mg, was stopped because of severe side effects. Another 10 women were given a loading dose of ampicillin plus additional ampicillin for 3 to 21 days and were followed for 4 to 76 days after treatment was stopped. Only two women remained culture positive after therapy. This study demonstrates that antimicrobial regimens that are frequently given to women in North America have significant activity against C. trachomatis.

Topics: Anti-Bacterial Agents; Chlamydia Infections; Chlamydia trachomatis; Erythromycin; Female; Humans; Random Allocation; Sulfisoxazole; Tetracycline; Urethritis; Uterine Cervicitis

65 patients with chlamydia-positive urethritis were treated with doxycycline and 59 with tetracycline chloride 1 g/day for one week. All steady sexual partners of these patients were treated with the same regimen during the same period. At control visits 2 and 3 weeks after the beginning of the treatment, all re-examined doxycycline-treated patients and all except 4 tetracycline-treated patients showed clinical cure and were free from signs of urethritis in the microscopical examination of Gram-stained smears from the urethra. Isolation of C. trachomatis was positive in 7 of the doxycycline-treated and 10 of the tetracycline-treated patients at the first control visit and in one more tetracycline-treated patient at the second control visit. The study stresses the importance of attempts to isolate C. trachomatis in cases without clinical or microscopical evidence of nongonococcal urethritis at control visits after short-term treatment with tetracyclines. The present investigation indicates that this is true also in cases in which all steady sexual partners are treated simultaneously.

Topics: Adult; Chlamydia trachomatis; Clinical Trials as Topic; Doxycycline; Humans; Male; Tetracycline; Urethritis

We treated 289 men with nongonococcal urethritis in a randomized, double-blind study with minocycline, 100 mg once or twice daily for 7 or 21 days. Ureaplasma urealyticum was isolated before treatment from 167 (58%). The pretherapy isolates from 82 men re-examined 6 to 8 days after initiation of treatment were viable. In six (7%) isolates were resistant to 256 microgram/mL or more of tetracycline. Tetracycline resistance was significantly correlated with persistence of U. urealyticum and persistence of nongonococcal urethritis during treatment. Recurrence of nongonococcal urethritis after initial resolution and recurrence of U. urealyticum after interim negative cultures were not correlated with tetracycline resistance of U. urealyticum. Thus tetracycline-resistant strains of U. urealyticum are a cause of persistent but not of recurrent nongonococcal urethritis.

Topics: Double-Blind Method; Drug Resistance, Microbial; Humans; Male; Minocycline; Random Allocation; Tetracycline; Ureaplasma; Urethritis

Some 4,263 women from special, family planning and gynecologic clinics were screened at random for the presence of H. vaginalis (C. vaginale) infection. Twenty-four percent of the women from the special clinics, 6% from the family planning and 4% from the gynecology clinics were culture positive although microscopic findings were somewhat higher than this. Of 582 women attending special clinics who were infected solely with H. vaginalis, only 261 complained of having an offensive discharge. Two hundred thirty-eight women reported "no symptoms," but 116 of them did have an offensive discharge on examination. These 582 women were treated with either ampicillin, ampicillin with probenecid or sulphonamide vaginal tablets. All were largely effective. Direct microscopy was regarded as being a reliable guide to H. vaginalis infection.

Topics: Ampicillin; Chloramphenicol; Cloxacillin; Erythromycin; Female; Gardnerella vaginalis; Haemophilus Infections; Humans; Male; Penicillins; Staining and Labeling; Streptomycin; Sulfonamides; Tetracycline; Urethritis

In a previous study treatment with minocycline 100 mg orally every day for seven days was as effective for nongonococcal urethritis (NGU) as 200 mg for seven days or 100 or 200 mg for 21 days. In this prospective, randomised study men with NGU received tetracycline either 500 mg or 250 mg four times daily for seven days. of 200 men initially enrolled, Chlamydia trachomatis was isolated from 40% and Ureaplasma urealyticum from 48%. Eight of 10 homosexual men compared with 39 (21%) of 190 bisexual or heterosexual men had negative culture results for both C trachomatis and U urealyticum (x2 = 15.5, P < 0.0005). U urealyticum was isolated more frequently from chlamydia-negative men and from men with 10 or fewer sex partners during their lifetime. Both regimens were equally effective in their in-vivo activity against C trachomatis and U urealyticum. Failure rates were similar with the two regimens. More obvious failure with purulent or profuse mucoid discharge and pyuria occurred more frequently with the 250-mg regimen (20% of 76 men on the 250-mg regimen compared with 7% of 67 men on the 500-mg regimen; x2 = 4.45, P < 0.05). Failure occurred more frequently in men who were initially chlamydia-negative and in men in whom U urealyticum persisted after medication. Thus, the 250-mg regimen appeared to be as effective as the 500-mg regimen in the initial treatment of NGU. However, one-third of men had persistent or recurrent urethritis with these regimens, and there is a need for antimicrobial agents with greater in-vivo activity, especially against chlamydia-negative NGU.

Topics: Chlamydia trachomatis; Humans; Male; Pyuria; Sexual Behavior; Tetracycline; Ureaplasma; Urethritis

In a prospective evaluation of antibiotic prophylaxis against gonorrhea, 1080 men were given 200 mg of oral minocycline or placebo after sexual intercourse with prostitutes in a Far Eastern port. Later, at sea, gonococcal infection was detected in 57 of 565 men given placebo and 24 of 515 men given minocycline (P less than 0.001). Minocycline prophylaxis completely prevented infection by gonococci susceptible to 0.75 microgram or less of tetracycline per milliliter, reduced the risk of infection or prolonged the incubation period in men exposed to gonococci susceptible to 1.0 to 2.0 micrograms per milliliter, but did not prevent infection or prolong incubation in men exposed to gonococci resistant to 2.0 micrograms. Minocycline did not increase the proportion of asymptomatic infections. Minocycline prophylaxis would probably have limited effectiveness as a public-health measure because of the tendency to select resistant gonococci.

Topics: Administration, Oral; Asia, Eastern; Coitus; Drug Evaluation; Drug Resistance, Microbial; Gonorrhea; Humans; Male; Minocycline; Naval Medicine; Neisseria gonorrhoeae; Sex Work; Tetracycline; Tetracyclines; Time Factors; United States; Urethritis

In a double-blind comparison of two regimens of triple tetracycline (Deteclo, Lederle) in the treatment of nongonococcal urethritis, 68 (88.6%) of 70 patients treated with one tablet twice for 21 days and seen four weeks after starting therapy had satisfactory results. This was significantly better than the findings among the 73 patients treated with one tablet twice daily for seven days and followed for four weeks, among whom only 47 (64.4%) had satisfactory results. Results were also better for the group treated with the 21-day regimen at three months afer the start of treatment. When analysed individually at four and 12 weeks, urethral discharge, urethral Gram-stained smears, and first-glass urine test all gave similar results, which were markedly better than those before treatment. It appears that the longer course of treatment it indicated where any regular partner may not be treated. Slightly fewer patients had satisfactory results among those who admitted consuming alcohol than among those who did not. Chlamydiae-negative patients, treated for seven days, had fewer clinically satisfactory results than other sub-groups.

Topics: Chlamydia trachomatis; Chlortetracycline; Clinical Trials as Topic; Demeclocycline; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; Humans; Male; Random Allocation; Recurrence; Tetracycline; Time Factors; Urethritis

Spectinomycin and tetracycline are alternative drugs to penicillin in the treatment of gonorrhea. To compare the efficacy of these agents and their propensity to select resistant gonococci, we treated 4043 patients randomly with either 2 or 4 g of spectinomycin once or 9 g of oral tetracycline for four days. Minimum cure rate for anogenital gonorrhea was 94 per cent with either drug. Oropharyngeal infection responded poorly to spectinomycin in men, with failure of therapy in six of 11. Postgonococcal urethritis in men was less common after tetracycline than after spectinomycin (P less than 0.005). Spectinomycin failure was not related to drug resistance. Tetracycline failure correlated with resistance (P less than 0.0002); one fifth of the isolates resistant to 1.0 mug per milliter of tetracycline were not eradicated. For several reasons, including the appearance of beta-lactamase-producing gonococci, it is no longer clear that penicillin G is the "drug of choice" for gonorrhea. Spectinomycin and tetracycline are equally acceptable alternatives, each with distinct advantages and disadvantages.

Topics: Administration, Oral; Drug Evaluation; Female; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Spectinomycin; Tetracycline; Urethritis

Details are given of a double-blind trial involving 400 cases in which tetracycline 500 mg. four times a day for 7 days was compared with tetracycline 250 mg. four times a day for 14 days and also of the findings in 311 cases treated with Deteclo 300 mg. three times a day for 3 weeks. The treatment in the double-blind trial were equally effective and appeared to be as effective as the long-term Deteclo therapy. When the results of these treatments were compared with those obtained previously with tetracycline 250 mg. four times a day for 4 days and allowance was made for the time at which the latter results have been assessed, it was concluded that neither the treatment used in the double-blind trial nor Deteclo 300 mg. three times a day for 3 weeks offered any advantage over the customary treatment with tetracycline 250 mg, four times a day for 4 days.

Topics: Chlortetracycline; Clinical Trials as Topic; Demeclocycline; Humans; Oxytetracycline; Tetracycline; Tetracyclines; Time Factors; Urethritis

The possible aetiological factors in non-gonococcal and non-specific urethritis are reviewed. The response of NSU to various courses of different tetracycline drugs is assessed. Prolonged courses of treatment did not give better results than shorter courses. When reviewing the infective aetiology of non-gonococcal urethritis, it was noted that more than one organism (or potential pathogen) would be present in many cases. It is therefore surmised that there may be at times a mixed aetiology and at other times a truly non-specific aetiology. Isolations by different workers have indicated that the following organisms might be expected: Chlamydia 40 per cent.; Mycoplasma-M. hominis 20 per cent., T-strain over 60 per cent.; Trichomonas 15 per cent.; Candida possibly over 5 per cent. Truly non-specific urethritis may account for 25 to 30 per cent. of cases.

Topics: Candida; Chlamydia; Clinical Trials as Topic; Female; Humans; Male; Mycoplasma; Tetracycline; Trichomonas vaginalis; Urethritis

A double-blind trial of oxytetracycline (Imperacin-I.C.I.) and tetracycline hydrochloride in a sustained-release formulation (Tetrabid-Organon) was carried out on 259 men suffering from non-specific urethritis. Patients who had NSU in the preceeding 3 months were excluded from the trial. The response to treatment assessed at 10 days was favourable in ninety patients out of 129 (35 per cent.) who received oxytetracycline and in 89 patients out of 130 (34 per cent.) who received Tetrabid-Organon. Eight patients in each group required re-treatment and the remainder failed to attend for follow-up. At 4 weeks after treatment one (1-3 per cent.) of 74 patients treated with Tetrabid-Organon and twenty (37-7 per cent.) of patients treated with oxytetracycline required further treatment. A large proportion of patients who were free of signs and symptoms at the first follow-up failed to return at 4 weeks, so that the true rates of cure at 4 weeks are difficult to assess. In a field such as venereology, the twice-daily administration of medication offers distinct advantages over a four-times-daily regime. This study suggests that Tetrabid-Organon, a tetracycline designed specifically for twice-daily dosage, is more effective than standard oxytetracycline, given twice daily, in the treatment of NSU. It was satisfying to find that the traditional advice concerning abstention from sexual activity and alcohol consumption during the treatment of NSU has a sound basis. The study showed a close correlation between recurrence of NSU and failure to follow such advice. It would be interesting to investigate the means by which alcohol consumption may act to delay recovery.

Topics: Administration, Oral; Adolescent; Adult; Aged; Alcohol Drinking; Clinical Trials as Topic; Delayed-Action Preparations; Humans; Male; Middle Aged; Oxytetracycline; Sexual Behavior; Tetracycline; Urethritis

A proctocol to be administered by nurses for the management of dysuria, frequent urination, and vaginal discharge was validated. In a randomized, controlled trial, 146 women were seen by both nurse and physician and then assigned to either the nurse-proctocol treatment plan or the physician treatment plan. The clinical data collected by the nurse showed no important differences from the physicians' data. The protocol recommended that 89 percent of the patients be sent home without seeing the physician. The physicians agreed with the protocol-recommended disposition in all but two cases. All patients with complications were appropriately referred to the physician. In follow-up, more than 95 percent of both groups reported symptomatic improvement, and repeat urine cultures were negative. We conclude that the protocol can be accurately administered, makes sound recommendations, is safe, and efficiently saves physician time.

Topics: Adolescent; Adult; Ampicillin; Candidiasis, Vulvovaginal; Female; Humans; Nurses; Physicians; Sulfisoxazole; Syndrome; Tetracycline; Trichomonas Infections; Urethral Diseases; Urethritis; Urinary Tract Infections; Urination Disorders; Vagina; Vaginal Diseases; Vaginitis

Topics: Adult; Clinical Trials as Topic; Gonorrhea; Humans; Male; Minocycline; Tetracycline; Urethritis

Topics: Cephalosporins; Clinical Trials as Topic; Drug Combinations; Erythromycin; Female; Gonorrhea; Humans; Male; Penicillin G Procaine; Penicillins; Probenecid; Sexually Transmitted Diseases; Spectinomycin; Syphilis; Syphilis, Congenital; Tetracycline; Time Factors; Urethritis

Topics: Carrier State; Clinical Trials as Topic; Female; Follow-Up Studies; Humans; Male; Placebos; Recurrence; Remission, Spontaneous; Sex Factors; Tetracycline; Time Factors; Urethritis

Topics: Drug Combinations; Follow-Up Studies; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Penicillin G Procaine; Probenecid; Sulfamethoxazole; Tetracycline; Trimethoprim; United States; Urethritis

Topics: Anti-Bacterial Agents; Chlortetracycline; Clinical Trials as Topic; Demeclocycline; England; Erythromycin; Humans; Leucomycins; Male; Tetracycline; Troleandomycin; Urethritis; Wales

Topics: Humans; Male; Oxytetracycline; Phosphates; Tetracycline; Time Factors; Urethritis

Topics: Clinical Trials as Topic; Female; Humans; Male; Metronidazole; Placebos; Tetracycline; Trichomonas Infections; Urethritis

Topics: Administration, Oral; Age Factors; Ampicillin; Gonorrhea; Humans; Hypersensitivity; Injections, Intramuscular; Male; Penicillins; Tetracycline; Time Factors; Urethritis

Topics: Acute Disease; Adolescent; Adult; Australia; Clinical Trials as Topic; Gonorrhea; Humans; Male; Marriage; Middle Aged; Penicillin G Procaine; Probenecid; Sexual Behavior; Single Person; Tetracycline; Urethritis

Topics: Chronic Disease; Clinical Trials as Topic; Humans; Lactose; Placebos; Streptomycin; Sulfamethazine; Tetracycline; Urethritis

Topics: Clinical Trials as Topic; Diarrhea; Humans; Male; Methacycline; Nausea; Protein Binding; Tetracycline; Time Factors; Urethritis

Topics: Bacteriological Techniques; Gonorrhea; Humans; Male; Military Medicine; Neisseria gonorrhoeae; Penicillin G Benzathine; Penicillin G Procaine; Penicillin Resistance; Probenecid; Staphylococcal Infections; Tetracycline; Urethritis; Vietnam

Topics: Adult; Gonorrhea; Humans; Kanamycin; Male; Penicillins; Tetracycline; Urethritis

Topics: Adult; Humans; Male; Placebos; Tetracycline; Urethritis

We tested the activity of ETX0914 against 187 Neisseria gonorrhoeae isolates from men with urethritis in Nanjing, China, in 2013. The MIC50, MIC90, and MIC range for ETX0914 were 0.03 μg/ml, 0.06 μg/ml, and ≤0.002 to 0.125 μg/ml, respectively. All isolates were resistant to ciprofloxacin, and 36.9% (69/187) were resistant to azithromycin. Of the isolates, 46.5% were penicillinase-producing N. gonorrhoeae (PPNG), 36% were tetracycline-resistant N. gonorrhoeae (TRNG), and 13% (24 isolates) had an MIC of 0.125 μg/ml for ceftriaxone. ETX0914 may be an effective treatment option for gonorrhea.

Topics: Anti-Bacterial Agents; Azithromycin; Barbiturates; Ceftriaxone; Ciprofloxacin; DNA Gyrase; Drug Resistance, Multiple, Bacterial; Gene Expression; Gonorrhea; Humans; Isoxazoles; Male; Microbial Sensitivity Tests; Morpholines; Neisseria gonorrhoeae; Oxazolidinones; Spiro Compounds; Tetracycline; Topoisomerase II Inhibitors; Urethritis

Resistant Neisseria gonorrhoeae has been evolving. This study assessed the antimicrobial susceptibility profile of isolates in the Pretoria region, South Africa. Isolates of N. gonorrhoeae from men with urethritis were tested for susceptibility to eight antimicrobial agents by disc diffusion, Etest and agar dilution methods. Chromosomal resistance to penicillin was found in 16% of isolates, 16% showed plasmid-mediated resistance and decreased susceptibility was seen in 73% of isolates. For the first time, there is evidence of high-level tetracycline resistance (36%). Ciprofloxacin resistance emerged at 7%. All isolates remained susceptible to ceftriaxone. In view of these findings of the emergence of quinolone-resistant N. gonorrhoeae, national treatment guidelines for syndromic management of sexually transmitted infections need to be urgently reviewed. The injectable preparation, ceftriaxone has to be considered as a first-line agent for the management of gonococcal infections. Overall, the gonococcal isolates in the Pretoria region remain susceptible to ceftriaxone, cefoxitin, cefpodoxime and spectinomycin.

Topics: Anti-Bacterial Agents; beta-Lactams; Cephalosporins; Drug Resistance, Bacterial; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillin Resistance; Quinolones; South Africa; Spectinomycin; Tetracycline; Tetracycline Resistance; Urethritis

Two hundred and thirty-three men and 85 women visiting STD clinics in western Sweden between April 1997 and March 1998 were examined for Mycoplasma genitalium and Chlamydia trachomatis. The bacteria were identified by the polymerase chain reaction (PCR) technique. Three women (3.5%) and 18 men (7%) were positive for M. genitalium. Seventeen (14%) of the 115 men with urethritis were infected but only one of the men was without urethritis. After treatment with tetracyclines for 10 days, one woman and 8 of the 13 men still harboured M. genitalium. M. genitalium-infected men did not have more life-time partners than other men visiting STD clinics. More men positive for M. genitalium gave a history of previous urethritis but the difference was not significant.

Topics: Anti-Bacterial Agents; Chlamydia trachomatis; Contact Tracing; DNA, Bacterial; Female; Female Urogenital Diseases; Humans; Male; Male Urogenital Diseases; Mycoplasma; Mycoplasma Infections; Polymerase Chain Reaction; Prevalence; Sexually Transmitted Diseases; Sweden; Tetracycline; Treatment Outcome; Urethritis

Topics: Anti-Bacterial Agents; Azithromycin; Chlamydia Infections; Chlamydia trachomatis; Chlortetracycline; Contact Tracing; Demeclocycline; Doxycycline; Drug Therapy, Combination; Erythromycin; Humans; Male; Ofloxacin; Recurrence; Tetracycline; Urethritis

To assess the effects of antibiotic treatment of urethritis or cervicitis on the incidence of recurrences of articular symptoms in Reiter's syndrome patients.. Retrospective evaluation of the medical charts of 109 patients living in Greenland.. Thirty-seven percent of the episodes of genitourinary tract inflammation that were not treated or were treated with penicillin were followed by arthritis, compared with 10% of those treated with tetracycline or erythromycin.. Antibiotics active against Chlamydia trachomatis reduced the risk of postvenereal arthritis in the population studied.

Topics: Adult; Arthritis; Arthritis, Reactive; Erythromycin; Female; Greenland; Humans; Incidence; Inuit; Male; Penicillins; Recurrence; Retrospective Studies; Sexually Transmitted Diseases; Tetracycline; Urethritis; Uterine Cervicitis

A study was performed on 321 patients with paratrachoma: acute follicular conjunctivitis-189, subacute-132. The first group of patients (108) received 1% Tetracycline ointment 4 to 5 times daily, the second group (103 patients)-1% Tetracycline ointment + 0.1% Dexamethasone eye drops, the third group (110 patients)-Eubetal ointment (tetracycline 0.5%, betamethasone 0.1%, chloramphenicol 1%, colistin). Therapeutic efficacy was higher in groups were antibiotics combined with corticosteroids. Cured in 4 weeks in group I-46.3%, in group II-72.8%, in group III-71.8%, cured in 6 weeks-75.9%, 88.3% and 86.4% respectively.

Topics: Acute Disease; Administration, Topical; Adolescent; Adult; Betamethasone; Chlamydia Infections; Chloramphenicol; Colistin; Conjunctivitis, Inclusion; Dexamethasone; Drug Combinations; Drug Therapy, Combination; Female; Humans; Male; Ointments; Ophthalmic Solutions; Tetracycline; Treatment Outcome; Urethritis; Uterine Cervicitis

Four cases of Chlamydia infection of the urogenital tract were received-recently in our out-patient clinic for foreign patients. The 4 patients were two couples. Both male patients had histories of coitus with other partners: among these two, one had suffered gonorrhea and the other was suspected of having had gonorrhea. Urogenital tract symptoms or sustained abnormal urine analysis results are characteristic of this disease, but in females often no obvious symptoms present. Measurements with fluorescence-labeled Chlamydia trachomatis monoclonal antibody provided a simple and accurate method and was used in the diagnosis of this disease. All the 4 cases were cured by tetracycline. Finally, current epidemics, infectious features, diagnosis and treatment for this disease are discussed.

Topics: Adult; Chlamydia Infections; Chlamydia trachomatis; Female; Humans; Male; Tetracycline; Urethritis; Uterine Cervicitis

The activity of minocycline, doxycycline, tetracycline, erythromycin, mepartricin and lincomycin against 35 freshly isolated Ureaplasma urealyticum strains was tested. Doxycycline was the most active. Twelve strains were resistant to minocycline and four of these were sensitive to erythromycin. Mepartricin showed no activity against the organisms at a concentration of 10 micrograms/ml. The susceptibility of 30 low-laboratory-passage Chlamydia trachomatis strains against tetracycline and erythromycin was tested. A variable degree of sensitivity to tetracycline and erythromycin was found, the median MIC values being 0.13 micrograms/ml and 0.025 micrograms/ml respectively. No resistant Chlamydia trachomatis strain was found.

Topics: Anti-Bacterial Agents; Chlamydia trachomatis; Doxycycline; Erythromycin; Humans; Lincomycin; Male; Mepartricin; Minocycline; Tetracycline; Ureaplasma; Urethritis

One hundred and nine Neisseria gonorrhoeae strains were isolated from urethral discharge of male patients in a health centre in Addis Ababa, identified following conventional procedures, and tested for penicillin and tetracycline susceptibility by the agar dilution technique. World Health Organization reference strains were also tested as controls. Penicillinase producing N. gonorrhoeae (PPNG) were identified using Oxoid beta-lactamase detection papers. Minimal inhibitory concentration (MIC) values of penicillin varied between less than 0.01 mg l-1 and greater than 10.24 mg l-1 while those of tetracycline, between less than 0.25 mg l-1 and 4.0 mg l-1. About 64% of isolates were resistant to penicillin, requiring MICs of greater than or equal to 0.64 mg l-1: 26% were resistant to tetracycline, requiring greater than or equal to 2 mg l-1 for inhibition. The rate of simultaneous resistance to both antibiotics was 18%. PPNG comprised 49% of isolates, of which 23% were resistant also to tetracycline. Of 70 penicillin-resistant strains, 17 (24%) were non-PPNG.

Topics: Adolescent; Adult; Ethiopia; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Neisseria gonorrhoeae; Penicillin Resistance; Penicillinase; Penicillins; Tetracycline; Tetracycline Resistance; Urethritis

A 21-year-old man developed acute pancreatitis on two separate occasions after a short-term course (less than 10 days) of tetracycline in the presence of normal liver and renal function. Although tetracycline is frequently listed as a cause of pancreatitis, this is only the second documented case of tetracycline-induced pancreatitis in an otherwise healthy person. We review the pertinent literature.

Topics: Acute Disease; Adult; Humans; Male; Pancreatitis; Tetracycline; Urethritis

Topics: Chlamydia; Chlamydia Infections; Erythromycin; Female; Humans; Male; Tetracycline; Urethritis; Vulvovaginitis

A case of gonococcal urethritis with bilateral tysonitis is discussed. The patient was treated successfully with oral tetracycline 500 mg 6 hourly for 10 days, with a complete resolution.

Topics: Adult; Balanitis; Gonorrhea; Humans; Male; Tetracycline; Urethritis

A young man who acquired gonococcal urethritis in the Far East was not cured by repeated i.v. treatment with a broad-spectrum penicillin. Cultures of pre- and post-treatment urethral specimens grew tetracycline-resistant penicillinase-producing Neisseria gonorrhoeae (PPNG) and tetracycline-resistant Ureaplasma urealyticum. The patient was successfully treated with erythromycin, to which both isolates were sensitive. The strain of N. gonorrhoeae carried a novel plasmid of 10.5 Md molecular mass in addition to plasmids previously observed in this organism. The strain of U. urealyticum carried two distinct plasmids, one with mass 4.9 Md and the other one with mass 8.1 Md. This report demonstrates that ureaplasmas can contain plasmids and raises the question if tetracycline resistance is controlled by plasmids or by the chromosome.

Topics: Adult; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Plasmids; Tetracycline; Ureaplasma; Urethritis

Topics: Chlamydia Infections; Chlamydia trachomatis; Endometritis; Female; Genital Diseases, Female; Humans; Pregnancy; Pregnancy Complications, Infectious; Salpingitis; Tetracycline; Urethritis; Uterine Cervicitis; Vaginal Smears; Vaginitis

Chlamydia trachomatis causes more sexually transmissible diseases in the United States than any other organism. Complications of chlamydial urethritis and cervicitis include epididymitis, salpingitis and neonatal pneumonia. Chlamydial infections can be easily treated but, until recently, they have been difficult to diagnose. Presumptive antichlamydial therapy for symptomatic/high-risk individuals was the first step taken towards control. With new methods of diagnosis becoming available, detection in asymptomatic women is the next critical step. Key populations for screening include clinics for family planning, abortion, student health, adolescent care and prenatal care. This article outlines the biology, diseases, diagnosis and treatment of C. trachomatis.

Topics: Antibodies, Monoclonal; Chlamydia Infections; Chlamydia trachomatis; Female; Fluoresceins; Humans; Male; Mass Screening; Nurse Practitioners; Pregnancy; Salpingitis; Tetracycline; Urethritis; Uterine Cervicitis

Topics: Adult; Emergencies; Esophagitis; Female; Humans; Tetracycline; Urethritis

120 patients with abacterial urethritis were studied for chlamydia. Clinical, cytological, serologic and electronenmicroscopic tests were performed. 66.60% of the tested persons were seropositive for C. trachomatis, 32.50% of all patients and 48.80% of the seropositive patients showed positive cytological tests. Direct electron microscopy of biopsy material of the urethra of 30 patients revealed chlamydial bodies in high concentrations. The incubation period was about 1-2 weeks. Oxytetracycline was used for 8 days, but had to be one- to four times repeated in resistent cases.

Topics: Adult; Antibodies, Bacterial; Chlamydia Infections; Chlamydia trachomatis; Complement Fixation Tests; Erythromycin; Humans; Male; Microscopy, Electron; Tetracycline; Urethritis

The case of an infertile man with oligospermia and symptoms of urethritis-prostatitis, whose spouse had a vaginal discharge, is reported. Microbiological analysis of appropriate specimens revealed a strain of tetracycline-resistant ureaplasma urealyticum in both patients. Using the transmission electron microscope, it was possible to demonstrate spermatozoal heads "infected" with microorganisms strongly resembling ureaplasma urealyticum.

Topics: Adult; Chlamydia Infections; Chlamydia trachomatis; Drug Resistance, Microbial; Female; Humans; Infertility, Male; Male; Mycoplasmatales Infections; Prostatitis; Sperm Head; Spermatozoa; Tetracycline; Ureaplasma; Urethritis; Vaginitis

Topics: Chlamydia Infections; Chlamydia trachomatis; Humans; Male; Pilot Projects; Tetracycline; Urethritis

The activity of tetracycline hydrochloride and minocycline hydrochloride was compared against 12 strains of Chlamydia trachomatis and Ureaplasma urealyticum; minocycline was more active in vitro against both organisms. A group of 145 men with non-gonococcal urethritis was treated for one week with either tetracycline hydrochloride 500 mg six hourly or minocycline 50 mg twice daily. The clinical results obtained were similar: 61 of 77 (79%) men treated with tetracycline and 53 of 68 (78%) men treated with minocycline were free from urethritis one to two weeks after completing treatment. Both antibiotics were clinically effective against C trachomatis, but activity against U urealyticum was less consistent. Side effects were noted in 14 (18%) men treated with tetracycline and eight (12%) men treated with minocycline; they were predominantly gastrointestinal.

Topics: Chlamydia trachomatis; Humans; Male; Microbial Sensitivity Tests; Minocycline; Tetracycline; Tetracyclines; Time Factors; Ureaplasma; Urethritis

Sixty-four men with non-gonococcal urethritis (NGU), seven with gonococcal urethritis (GU), and 30 who had no symptoms or signs of urethritis were studied. Chlamydia trachomatis was isolated from urethral specimens taken from 22% of the men with NGU, and 18% with GU, but not from those who did not have urethritis even though 20 (67%) of them had a history of NGU, GU, or both. The chlamydial isolation rate for men having NGU for the first time was 30%. Ureaplasma urealyticum was isolated from 42% of the men with NGU, 43% of men with GU, and 27% of those without urethritis.In addition to aerobes anaerobes were isolated frequently from men whether or not they had urethritis, the most common being anaerobic Corynebacteria, peptococci, and micro-organisms of the Bacteroides-Fusobacteria group. There was no appreciable difference in the overall isolation of anaerobes from men with NGU (89%) or from those without disease (80%). The rate of isolation of a Gram-negative anaerobic bacillus from men with NGU (50%) was, however, strikingly different to that from men with GU (14%) or from those without disease (13%). Furthermore, this bacillus was recovered from 28 (56%) of 50 men with NGU who were considered chlamydia-negative and from 19 (61%) of 31 men who were both chlamydia-negative and ureaplasma-negative. The effect of antibiotic treatment was evaluated in a few patients only, so that although those from whom the Gram-negative bacillus was eliminated by tetracycline recovered clinically there is a need for a prospective therapeutic trial to evaluate further the importance of the bacillus.

Topics: Adolescent; Adult; Bacteria; Chlamydia trachomatis; Humans; Male; Mycoplasma; Oxygen Consumption; Tetracycline; Urethra; Urethritis

The records of 1,381 patients with gonorrhea were examined by the Massachusetts Department of Public Health to determine the efficacy of their treatment schedules. Urethritis, cervicitis and pharyngitis were treated with 4.8 million u. of aqueous procaine penicillin G intramuscularly, without probenecid. Cure rates were 98 percent in urethritis, 97 percent in pharyngitis and 98 percent in cervicitis. Patients allergic to penicillin were treated with tetracycline orally or spectinomycin intramuscularly. In patients with proctitis, a 98 percent cure rate was achieved with one intramuscular injection of procaine penicillin G, followed by ampicillin orally for four days.

Topics: Adult; Ampicillin; Drug Administration Schedule; Female; Gonorrhea; Humans; Male; Pelvic Inflammatory Disease; Penicillin G Procaine; Penicillin Resistance; Pharyngitis; Proctitis; Spectinomycin; Tetracycline; Urethritis; Uterine Cervicitis

Chlamydiae are obligate intracellular parasites, bacteria with a peculiar biology. They belong to the genus Chlamydia which includes two species: C. psittaci and C. trachomatis. A wide range of hosts, including birds, mammals and man can be infected by chlamydiae. The diseases chlamydiae can produce include psittacosis, lymphogranuloma venereum, trachoma, inclusion conjunctivitis, urethritis, cervicitis, pelvic inflammatory disease, and neonatal pneumonia. The diagnosis of chlamydial infection may be made by visualization of the organism in direct smears, isolation of the agent in cell culture, or by demonstrating a significant rise in antibody titer. Chlamydial infection may be treated with tetracycline, erythromycin, or sulfonamides.

Topics: Adult; Arthritis, Reactive; Child; Chlamydia Infections; Conjunctivitis, Inclusion; Epididymitis; Erythromycin; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lymphogranuloma Venereum; Male; Pelvic Inflammatory Disease; Pneumonia; Sexually Transmitted Diseases; Tetracycline; Trachoma; Urethritis; Uterine Cervicitis

Four hundred three men with signs and symptoms of urethritis were examined by stained slide and culture of urethral exudate. Of these slides, 14.1% were interpreted as "borderline" for gonorrhea, ie, showing typical Gram-negative diplococci on microscopic examination located extracellularly only. Of these, only 10.5% were culture positive for Neisseria gonorrhoeae. Patients with urethritis whose slides are "borderline" should be treated as for nongonococcal urethritis with tetracycline hydrochloride and not with aqueous penicillin G procaine.

Topics: Diagnosis, Differential; Exudates and Transudates; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Penicillin G Procaine; Staining and Labeling; Tetracycline; Urethra; Urethritis

Topics: Chlamydia Infections; Chlamydia trachomatis; Female; Humans; Male; Neisseria gonorrhoeae; Tetracycline; Urethritis

Chlamydia trachomatis is being recognized as an important sexually transmitted disease in adolescents and young adults. This report reviews the recent literature regarding the many clinical entities encompassed by this organism; this includes urethritis and cervicitis as well as epididymitis, salpingitis, peritonitis, perihepatitis, urethral syndrome, Reiter syndrome, arthritis, endocarditis, and others. It is emphasized that many aspects of chlamydial infections parallel those of gonorrhea, including incidence, transmission, carrier state, reservoir, complications, (local and systemic), and others. A paragonococcal spectrum of sexual chlamydial disorders is discussed as well as effective antibiotic therapy. This microbiological agent must always be considered if venereal disease is suspected by the clinician in teenagers or adults. Mixed infections with Chlamydia trachomatis and Neisseria gonorrhoeae are common in both males and females. It may be preferable to treat gonorrhea with tetracycline to cover for this possibility.

Topics: Adolescent; Adult; Chlamydia Infections; Chlamydia trachomatis; Diagnosis, Differential; Female; Gonorrhea; Humans; Male; Sexually Transmitted Diseases; Tetracycline; Urethritis; Uterine Cervicitis

Topics: Adult; Chlamydia Infections; Erythromycin; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Infant, Newborn; Male; Tetracycline; Urethritis; Urinary Tract Infections

We studied 187 men with symptoms and signs of chronic prostatitis or prostatosis and 108 healthy controls. Ureaplasma urealyticum was isolated from 103 (55.1 per cent) of the patients and from 24 (22.2 per cent) of the controls. When quantitative culture of Ureaplasma urealyticum is considered a typical histogram of prostatitis was evident in 36 patients (19.3 per cent) using the Stamey localization technique. In 20 of the 36 patients the etiology was uncertain for various reasons. Evidence was provided that Ureaplasma urealyticum could be considered as the etiologic agent of the disease in at least 16 (8.6 per cent) of the 187 patients with chronic prostatitis studied.

Topics: Adolescent; Adult; Chronic Disease; Follow-Up Studies; Humans; Male; Middle Aged; Mycoplasmatales Infections; Prostatitis; Semen; Tetracycline; Ureaplasma; Urethritis

For men with urethral discharge, a simple gram stained smear is 98% sensitive and over 99% specific in detecting gonococcal infection when compared to a single Thayer-Martin culture. The smear is less than 50% sensitive in asymptomatic urethritis. Neither Fluorescent antibody nor various serologic tests offer any diagnostic advantages over smears and/or cultures and they are not cost-effective. Treatment of gonococcal urethritis may be successfully accomplished with a variety of antibiotic regimens. Tetracycline hydrochloride (500 mg four times a day for 5 days) is highly effective, inexpensive, and is active against Chlamydia trachomatis; post gonococcal urethritis (PGU) is therefore uncommon. Aqueous Procaine Penicillin G (4.8 million units IM with 1 g of probenecid) has become the standard in the United States but suffers from higher cost, the need for refrigeration, occasional alarming toxic procaine reactions, and a high incidence of PGU. Spectinomycin 2 g IM remains expensive but is the regimen of choice for treatment failures and for Neisseria gonorrhoeae that produce penicillinase (PPNG). Other antibiotics active against PPNG are cotrimoxozole, cefoxitin, and cefuroxime. PNNG have now been reported from 27 countries throughout the world, but have attained significant prevalence in only a few areas of East Asia and West Africa. Because gonococcal patterns of antibiotic resistance are constantly changing, each region of the world needs to monitor treatment results and maintain some surveillance over sensitivity to antibiotics.

Topics: Gonorrhea; Humans; Male; Penicillin G Procaine; Probenecid; Spectinomycin; Tetracycline; Urethritis

Topics: Chlamydia Infections; Chlamydia trachomatis; Female; Humans; Male; Minocycline; Sexually Transmitted Diseases; Tetracycline; Urethritis

Topics: Humans; Recurrence; Tetracycline; Urethritis

The most frequently seen type of infectious ophthalmia neonatorum, inclusion conjunctivitis, is caused by the organism Chlamydia trachomatis. This agent is known to be transmitted sexually. Until recently, the infections produced by C trachomatis were though to be relatively benign. Recent evidence, however, suggests that the organism may produce urethritis and epididymitis in the male; cervicitis, cervical erosions, salpingitis, and puerperal infections in the female; and prematurity and pneumonitis in the infant. An infant who develops ophthalmia neonatorum should be thoroughly evaluated for the presence of a chlamydial infection. In many instances the first evidence of chlamydial infection within the parents will be the development of inclusion conjunctivitis in their newborn infant. Family members of infants with inclusion conjunctivitis who manifest any evidence of clinical disease should be evaluated and treated with appropriate antibiotics.

Topics: Adult; Chlamydia Infections; Chlamydia trachomatis; Conjunctivitis, Inclusion; Female; Humans; Infant, Newborn; Male; Ophthalmia Neonatorum; Salpingitis; Tetracycline; Urethritis

We have briefly presented practical approaches to the management of the most common disorders caused by sexually transmitted pathogens, including pelvic inflammatory disease, urethritis in men, genital lesions, vaginal discharge, and syphilis. Guidelines for the management of gonorrhea may change if penicillin-resistant strains become more prevalent. Areas which require further research include the treatment of genital herpes and the prevention of recurrences, the treatment of nonspecific vaginitis, and definition of the importance of metronidazole toxicity.

Topics: Anti-Bacterial Agents; Candidiasis, Vulvovaginal; Female; Genital Diseases, Female; Genital Diseases, Male; Gonorrhea; Herpesviridae Infections; Humans; Male; Pelvic Inflammatory Disease; Penicillin G; Pharyngeal Diseases; Pregnancy; Sexually Transmitted Diseases; Syphilis; Tetracycline; Urethritis; Vaginitis

312 patients with non-specific prostato-urethritis were investigated with a standardised procedure using the four glass test. In 42.3% of patients mycoplasma was isolated which in almost all cases was Ureaplasma urealyticum. Clinically patients were symptom-free after eradication of mycoplasma in cases where previously urea-plasma counts of more than 10,000 CFU/ml prostatic secretion and of more than 1000 CFU/ml urine had been demonstrated. In cases where there were smaller counts of Ureaplasma urealyticum and where Mycoplasma hominis had been demonstrated tetracycline therapy did not lead to cure in any case.

Topics: Adult; Cell Count; Humans; Male; Middle Aged; Prostatitis; Tetracycline; Ureaplasma; Urethritis

In a comparative trial minocycline was the best oral tetracycline compound for twice-daily administration in the treatment of non-specific urethritis. A review six months later showed that 29% of patients had needed further treatment, 35% of these more than one month after initial treatment and 12% between three and six months later. The history revealed no evidence of predisposition to non-specific urethritis among patients in whom relapse occurred. Multiple relapses were in the groups of patients who relapsed earliest. These cases proved more resistant to subsequent treatment, but all patients were eventually cured. The records of female contacts showed that 29% were symptomatic, 44% had an abnormal appearance of the cervix, but only 11% had inflammatory changes detected on cytological smear. A previous report was confirmed that there was no apparent benefit from the empirical treatment of contacts; possible reasons for this are given.

Topics: Adolescent; Adult; Female; Humans; Male; Middle Aged; Minocycline; Oxytetracycline; Recurrence; Tetracycline; Tetracyclines; Urethritis

Topics: Ethics, Medical; Humans; Research Design; Tetracycline; Urethritis

Topics: Adolescent; Adult; Age Factors; Gonorrhea; Humans; Male; Middle Aged; Recurrence; Retrospective Studies; Tetracycline; Urethritis

A trial comparing the efficacy of three different tetracyclines, each in two different dosage regimens, in the treatment of non-specific urethritis is described. There was a significant association between the retreatment rate and sexual intercourse. Age, race, duration of symptoms, previous infection, and indulgence in alcohol did not appear to influence the results whereas treatment of sexual contacts before resumption of sexual intercourse significantly reduced the retreatment rate. Single-dose treatment with doxycycline was shown to be ineffective. Treatment with doxycycline for seven days or triple tetracycline for seven days was less effective than triple tetracycline for 21 days or oxytetracyline for seven or 21 days, all of which gave the same success rate.

Topics: Adult; Alcohol Drinking; Coitus; Doxycycline; Drug Administration Schedule; Humans; Male; Middle Aged; Oxytetracycline; Tetracycline; Tetracyclines; Urethritis

The worldwide increase in the incidence of sexually transmitted diseases confronts the physician to an increasing extent with this group of infections. The high morbidity and the change in the clinical picture of gonorrhea, especially its asymptomatic form, give rise to extragenital complications which frequently lead the patient to the internal specialist in the first instance. Non-gonorrheal urethritis, in particular the infectious form, is undergoing intensive research. A number of organisms may be responsible, but a non-infectious origin must also be kept in mind. Syphilis is still important. The late stages of the disease have become rare thanks to highly effective therapy with antibiotics. The early stages of the infection, however, must always be considered in the differential diagnosis of any genital or anal affection, and also in generalized exanthemas of unknown origin. Homosexual transmission presents diagnostic problems of its own. Serological mass screening is essential. Interpretation of the results must take into account the different specificity of the various serological tests and their indication.

Topics: Erythromycin; Family Practice; Female; Gonorrhea; Hepatitis; Humans; Male; Neisseria gonorrhoeae; Penicillins; Proctitis; Sepsis; Sexually Transmitted Diseases; Syphilis; Tetracycline; Urethritis

Chlamydia organisms were found in 42 per cent of patients with non-specific urethritis and these organisms probably were the cause of the urethritis. Contact is by venereal means. The drug of choice is 500 mg. tetracycline every 6 hours for 10 days.

Topics: Chlamydia Infections; Chlamydia trachomatis; Female; Humans; Male; Sexually Transmitted Diseases; Tetracycline; Urethritis

Topics: Female; Humans; Male; Tetracycline; Urethritis

Topics: Carrier State; Corynebacterium; Corynebacterium Infections; Female; Humans; Male; Tetracycline; Ureaplasma; Urethritis

Our investigationes during the last seven years stress the importance of mycoplasma hominis and ureaplasma on the so called abacterial inflammation of the urogenital tract. Because of diagnostic problems and differential diagnoses only specialized centers should explore these inflammatory conditions. Therapy is possible, however, by dermatologists, urologists, gynecologists, and general practitioners.

Topics: Diagnosis, Differential; Doxycycline; Erythromycin; Female; Humans; Male; Mycoplasma; Mycoplasma Infections; Prostatitis; Specimen Handling; Tetracycline; Ureaplasma; Urethritis; Urinary Tract Infections

The conclusions, where pertinent, of the 10 papers on the treatment of non-specific urethritis which have appeared in the British Journal of Venereal Diseases between 1971 and now are reviewed. Recent studies purport to argue, but in fact assume, that tetracyclilne treatment for non-specific urethritis is both effective and desirable; current practice agrees with this assumption. To prove effectiveness, studies over much longer follow-up periods would be necessary. These studies should compare results not only of different methods and doses of tetracycline, of different regimens, and of different types of the drug; they should also compare results over a prolonged period with placebos and with other drugs, for instance those outside the antibiotic range and with no suspected side effects. Only then would it be reasonable to hold a firm view on the desirability or the effectiveness of the treatment. With patience and properly conducted experiments results may emerge to justify some view. At the moment the data are ill-assembled although voluminous and fail to support conclusions that have any clarity or force; moreover they are so haphazard that they cannot be compared with one another. Some venereologists are sceptical about treatment, some advocate the administration of one single dose, others say the four- or five-day regimen is preferable, and so on up to those who maintain that the 21-day regimen is the best. The coexistence of such mutually incompatible, firmly-held views may well suggest that the whole system of investigation put together to validate such views is quite inappropriate. That would be a radical thesis, and perhaps none the worse for that. What is not a radical thesis, however, is that at present the whole system of data and argument is in disarray.

Topics: Humans; Oxytetracycline; Tetracycline; Urethritis

Topics: Coitus; Doxycycline; Female; Humans; Male; Middle Aged; Mycoplasma Infections; Serotyping; Tetracycline; Ureaplasma; Urethritis

A positive microbiological evidence could be obtained 54 times from the smear of the exterior genitals of 80 women suffering from complaints that were caused by urethritis, criteria of the examinations being sterile catheter specimen, negative cystoscopical findings, and missing indications to anatomical changes in the urethral region. Cytological examinations of these cases with regard to the vaginal epithelium had the following results:Group I:6 times; group II: 37 times; group IIW:8 times; group IIId: once; group IVa:twice. The cytological tests were carried out according to the method of papanicolaou as modified by Soost. Furthermore, we could state the following degrees of purity: Degree I: 8 times; degree II:16 times; degree III: 30 times. The cytological examinations of the urethral epithelium demonstrated, in 52 cases, an increased appearance of "nude" completely exposed epithelial cell nuclei--a fact corresponding to a degenerative autolysis (according to Wied). In the 26 women with missing atypical germ flora within the region of the exterior genitals, exclusively groups I (according to Papanicolaou and Soost) and degrees of purity I were stated. These persons also demonstrated remarkably grave psychical disturbances, especially in the intimate regions. In the cases of positive microbiological evidence, the following measures have proved satisfactory: Vaginal hygienization combined with a directly aimed antibacterial therapy, and the prescription of preparations containing lactic acid. A transitory discontinuation of contraceptives is being discussed. Our examination results are emphasizing the necessity of an analysis of the germ flora in cases of complaints arising from urethritis. Also psychical disturbances must be taken into consideration in cases of missing urological and gynaecological criteria of evidence.

Topics: Candidiasis, Vulvovaginal; Cervix Uteri; Chronic Disease; Female; Humans; Male; Metronidazole; Mycoplasma Infections; Nystatin; Psychophysiologic Disorders; Tetracycline; Trichomonas Vaginitis; Urethra; Urethritis; Vagina; Vaginal Diseases

A patient with nonspecific urethritis (NSU) and his consort were examined for infection with NSU corynebacteria, mycoplasmas, and gonococci. No classic and T-mycoplasmas or gonococci were cultured, but one species of NSU corynebacteria was isolated not only from the patient's urethral discharge during three episodes of NSU but also from his consort. It was not isolated after successful treatment of the patient with tetracycline and the use of condoms prevented reoccurrence of urethritis. This NSU corynebacterium was isolated previously from one epididymitis patient and two NSU patients but not from any of the normal male and female subjects examined. Therefore, this strain is considered to be one of the etiologic agents of NSU and female subjects are asymptomatic carriers. In consequence, it is suggested that NSU corynebacteria which are commensals and pathogens of the male and female urogenital tracts should be incorporated in a new species, of the Coryneform group, and that this strain should be the type species, Corynebacterium genitalium n. sp.

Topics: Adult; Contraceptive Devices, Male; Corynebacterium; Corynebacterium Infections; Female; Humans; Male; Sexually Transmitted Diseases; Tetracycline; Urethritis

Nongonococcal urethritis may now account for most cases of symptomatic urethritis seen at VD clinics in the United States. Well-controlled etiologic studies in nongonococcal urethritis have implicated Chlamydia in over 40% of cases but the etiology of Chlamydia-negative cases remains uncertain. Tetracycline provides effective antimicrobial therapy, but tests for cure are often inadequate, and distinguishing relapse and reinfection is difficult. For tetracycline-allergic patients, erythromycin should be used. Control measures to decrease transmission of nongonococcal urethritis are not well established.

Topics: Chlamydia Infections; Erythromycin; Female; Humans; Male; Mycoplasma Infections; Sexually Transmitted Diseases; Tetracycline; Trichomonas Infections; Ureaplasma; Urethritis

Topics: Adolescent; Ampicillin; Anti-Bacterial Agents; Arthritis; Child; Child, Preschool; Coitus; Female; Gonorrhea; Humans; Infant; Infant, Newborn; Male; Penicillin G Procaine; Pharyngeal Diseases; Pregnancy; Pregnancy Complications, Infectious; Probenecid; Salpingitis; Spectinomycin; Syphilis Serodiagnosis; Tetracycline; Urethritis

Gonorrhea, the nation's second most frequently reported communicable disease, will affect more than a million persons this year. The following is the latest treatment schedule issued by the USPHS Center for Disease Control, Atlanta.

Topics: Adolescent; Ampicillin; Cephalosporins; Child; Child, Preschool; Drug Therapy, Combination; Erythromycin; Female; Gonorrhea; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Male; Penicillin G Procaine; Pharyngitis; Pregnancy; Pregnancy Complications, Infectious; Probenecid; Salpingitis; Spectinomycin; Sulfides; Tetracycline; Tetrazoles; Thiadiazoles; Urethritis

Isolates of Neisseria gonorrhoeae from 256 patients contracting acute gonococcal urethritis, primarily in the Republic of the Phillipine Islands, in 1971, were tested for the minimum inhibitory concentrations of five antibodies. The median is advocated as a measurement for comparison of ranges of MIC values; the median MIC of penicillin for 258 isolates was 0-23 mug/ml. A positive correlation coefficient was observed for the susceptibility of isolates to penicillin, spectinomycin, cephaloridine, and tetracycline.

Topics: Anti-Bacterial Agents; Cephalexin; Cephaloridine; Drug Combinations; Humans; Male; Microbial Sensitivity Tests; Naval Medicine; Neisseria gonorrhoeae; Penicillins; Philippines; Spectinomycin; Tetracycline; Urethritis

Topics: Ampicillin; Child; Female; Gonorrhea; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Pelvic Inflammatory Disease; Penicillin G Procaine; Pharyngitis; Probenecid; Spectinomycin; Syphilis; Tetracycline; United States; United States Public Health Service; Urethritis

Topics: Antigens, Viral; Antiviral Agents; Female; Herpes Simplex; Humans; Male; Metronidazole; Mycoplasma Infections; Nystatin; Oxytetracycline; Tetracycline; Urethritis

The case is reported of a man with schistosomiasis of the bladder which gave rise to non-gonococcal urethritis. Diagnosis was confirmed by finding the characteristic terminal-spined Schistosoma haematobium ova in the urine deposit. The cystoscopic appearances further confirmed the disease and its stage. The patient responded satisfactorily to treatment although the follow-up period was short.

Topics: Adult; Humans; Male; Niridazole; Schistosoma haematobium; Schistosomiasis; Tetracycline; Urethritis; Urinary Bladder Diseases

108 male patients with non-gonococcal urethritis have been treated with minocycline given as two 100 mg. tablets initially, followed by one tablet twice a day over a period of 6 days (13 tablets). Of 96 patients followed, re-treatment for non-gonococcal urethritis within 3 months was undertaken in ten (10.4 per cent.). The findings are compared with those previously reported in seven series involving six other tetracyclines and with nine other treatment regimens. All of the tetracyclines proved superior to other agents and the best results combined with simplicity of administration were obtained with minocycline. Two patients complained of soreness of the mouth after 1 week but no other side-effects were reported. Minocycline thus gives excellent results in the treatment of non-gonococcal urethritis. In the dosage used it was also successful against gonorrhoea in seven patients treated. It is therefore particularly useful in cases in which gonorrhoea is suspected but not found in the smears or in which the smears cannot be read immediately.

Topics: Follow-Up Studies; Gonorrhea; Humans; Male; Minocycline; Tetracycline; Tetracyclines; Urethritis

The effect of minocycline on nongonococcal urethritis (NGU) was investigated, with particular reference to its action against Chlamydia trachomatis. Preliminary laboratory studies showed that the drug was active against a laboratory chlamydial strain (Lb4f) in vitro. A group of 133 men with first attacks of NGU was then treated with minocycline, 100 mg twice daily for 3 weeks. Isolates of C trachomatis were obtained from 33 of these men before treatment; all of them gave negative results on cell culture after therapy. Of the 133 patients, 119 (90%) had symptoms on their first attendance, but after one week's treatment only 16 of the 133 (12%) and after 3 weeks 6 of the 133 (5%) had symptoms. All 133 men had demonstrable urethritis initially; by the end of the first week of treatment only 43 of the 133 (32%) and by the end of the third week 32 of the 133 (24%) had evidence of urethritis. There were no differences in clinical response between the Chlamydia-positive and Chlamydia-negative groups. A group of 24 female sexual contacts of men with NGU yielded C trachomatis on cell culture. After 3 weeks' therapy with minocycline all these women gave negative results on cell culture. It is concluded that minocycline is a useful addition to existing remedies for NGU. The future structure of treatment trials for NGU is discussed.

Topics: Animals; Chick Embryo; Chlamydia; Chlamydia Infections; Chlamydia trachomatis; Drug Evaluation; Female; Humans; Male; Minocycline; Tetracycline; Tetracyclines; Urethritis; Uterine Cervicitis

The improved control over most infectious disease does not extend to venereal infections, and these now provide the major medical problem encountered in wartime. This factor should be recognized when staff and facilities are being provided for wartime medical services. Unique problems of management of both physical and psychological illness may result from promiscuity in a foreign land during war, and specialist venereologists are as necessary as surgeons and physicians.

Topics: Australia; Chancroid; Drug Resistance, Microbial; Humans; Male; Military Medicine; Penile Diseases; Seasons; Sexually Transmitted Diseases; Skin Ulcer; Streptomycin; Sulfisoxazole; Tetracycline; Urethritis; Vietnam; Warfare; Warts

Topics: Administration, Oral; Female; Gonorrhea; Humans; Male; Penicillins; Sexually Transmitted Diseases; Syphilis; Tetracycline; Urethritis

The functional state of the testis due to the effect of antibacterial therapy was studied in 50 patients suffering from chronic inflammatory diseases of the urinary-genital system and treated with neomycin, streptomycin, tetracycline, furadonin and furagin. It was shown that the above nitrofurans and neomycin had a negative effect on the testis function lowering the number of the spermatozoa in 1 ml and the whole ejaculate and their mobility. Contrary to it tetracycline therapy had no significant effect on the spermatozoa number, while the use of streptomycin was accompanied by a certain tendency to an increase in their number. The data were to some extent in certain accordance with the results of the experimental studies.

Topics: Adult; Anti-Bacterial Agents; Chronic Disease; Depression, Chemical; Humans; Hydantoins; Male; Middle Aged; Neomycin; Nitrofurans; Nitrofurantoin; Prostatitis; Sperm Motility; Spermatogenesis; Spermatozoa; Streptomycin; Testis; Tetracycline; Time Factors; Urethritis

Topics: Acute Disease; Administration, Oral; Ampicillin; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillins; Tetracycline; Urethritis; Valerates

Of 53 patients with acute uncomplicated gonorrhea treated with amoxicillin 2 g and probenecid 1 g orally as a single administration, six failed to return for follow-up examination, 10 developed postgonococcal urethritis and one was a treatment failure. The remainder achieved symptomatic cure in an average of 2.3 days. Adverse drug effects were infrequent, mild and transient. We conclude that this dose of amoxicillin and probenecid is a safe and effective treatment regimen.

Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Amines; Drug Evaluation; Female; Follow-Up Studies; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Penicillins; Probenecid; Tetracycline; Urethritis

Topics: Administration, Oral; Adult; Doxycycline; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Neisseria gonorrhoeae; Penicillin G; Penicillin Resistance; Streptomycin; Tetracycline; Urethritis

Topics: Adolescent; Adult; Child; Erythromycin; Humans; Male; Middle Aged; Mycoplasma; Mycoplasma Infections; Neisseria gonorrhoeae; Tetracycline; Urethra; Urethritis

Topics: Adolescent; Adult; Ampicillin; Biopsy; Coitus; Female; Genital Diseases, Female; Gonorrhea; Humans; Hydrocortisone; Lip; Lip Diseases; Lymphangitis; Male; Penile Diseases; Penis; Tetracycline; Urethritis; Vulva

Topics: Adolescent; Adult; Chronic Disease; Drug Combinations; Drug Therapy, Combination; Female; Gonorrhea; Humans; Immunotherapy; Middle Aged; Oleandomycin; Pelvic Inflammatory Disease; Prodigiosin; Tetracycline; Trichomonas Infections; Urethritis; Uterine Cervicitis

Topics: Adult; Cervix Mucus; Child; Family Practice; Female; Humans; Leukocytes; Male; Oxytetracycline; Sexually Transmitted Diseases; Tetracycline; Urethritis

Topics: Adult; Arthritis; Drug Resistance, Microbial; Erythromycin; Humans; Male; Microbial Sensitivity Tests; Microscopy, Phase-Contrast; Mycoplasma; Mycoplasma Infections; Tetracycline; Urethritis

Topics: Adolescent; Adult; Family Characteristics; Follow-Up Studies; Gonorrhea; Humans; Male; Marriage; Middle Aged; Minocycline; Tetracycline; Urethritis

Topics: Administration, Oral; Anemia, Hemolytic; Blood-Brain Barrier; Chlortetracycline; Demeclocycline; Doxycycline; Drug Hypersensitivity; Female; Glucosephosphate Dehydrogenase Deficiency; Gonorrhea; Humans; Injections, Intramuscular; Intestinal Absorption; Male; Methacycline; Minocycline; Oxytetracycline; Penicillins; Tetracycline; Urethritis

Topics: Administration, Oral; Adolescent; Adult; Chlortetracycline; Demeclocycline; Drug Combinations; Humans; Male; Middle Aged; Oxytetracycline; Tetracycline; Time Factors; Urethritis

Topics: Administration, Oral; Adolescent; Adult; Chlortetracycline; Demeclocycline; Diarrhea; Drug Combinations; Gonorrhea; Humans; Male; Metoclopramide; Microbial Sensitivity Tests; Nausea; Promazine; Recurrence; Tetracycline; Urethritis; Vomiting

Topics: Administration, Oral; Ampicillin; Doxycycline; Female; Gonorrhea; Humans; Injections; Kanamycin; Male; Mycoplasma Infections; Neisseria gonorrhoeae; Penicillin G Procaine; Penicillin Resistance; Probenecid; Pyuria; Recurrence; Sex Factors; Spectinomycin; Tetracycline; United States; Urethritis

Topics: Abortion, Spontaneous; Arthritis, Rheumatoid; Birth Weight; Erythromycin; Female; Humans; Mouth Diseases; Mycoplasma; Mycoplasma Infections; Pharyngitis; Pregnancy; Tetracycline; Time Factors; Urethritis

Topics: Adolescent; Adult; Humans; Male; Middle Aged; Tetracycline; Trachoma; Urethritis

Topics: Adult; Humans; Male; Mycoplasma; Mycoplasma Infections; Sexually Transmitted Diseases; Tetracycline; Urethritis

Topics: Chancroid; Drug Combinations; Erythromycin; Female; Gonorrhea; Granuloma Inguinale; Humans; Injections, Intramuscular; Kanamycin; Lymphogranuloma Venereum; Male; Metronidazole; Penicillin Resistance; Penicillins; Rifampin; Sexually Transmitted Diseases; Streptomycin; Sulfamethoxazole; Sulfonamides; Syphilis; Tetracycline; Trimethoprim; Urethritis

Topics: Acute Disease; Adult; Age Factors; Antifungal Agents; Female; Humans; Male; Tetracycline; Urethritis

Topics: Arthritis; Arthritis, Reactive; Female; Haemophilus Infections; Humans; Hypersensitivity; Inclusion Bodies; Male; Mycoplasma Infections; Mycoses; Oxytetracycline; Tetracycline; Trichomonas vaginalis; Urethritis; Uveitis

Topics: Arthritis, Rheumatoid; Complement Fixation Tests; Humans; Mycoplasma; Mycoplasma Infections; Pneumonia; Sputum; Tetracycline; Urethritis

Topics: Adult; Contraceptives, Oral; Female; Gonorrhea; Humans; Marriage; Metronidazole; Tetracycline; Time Factors; Trichomonas Vaginitis; Urethritis

Topics: Adolescent; Adult; Gonorrhea; Humans; Male; Middle Aged; Oleandomycin; Tetracycline; Trichomonas Infections; Urethritis

Topics: Arthritis; Erythromycin; Humans; Mycoplasma Infections; Pneumonia; Serologic Tests; Switzerland; Tetracycline; Urethritis

Topics: Adolescent; Adult; Age Factors; Carrier State; Female; Gonorrhea; Humans; Male; Mycoplasma; Mycoplasma Infections; Sex Factors; Tetracycline; Urethritis

Topics: Cervix Uteri; Culture Media; Education, Medical, Continuing; Education, Medical, Graduate; Female; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Penicillin G Benzathine; Penicillin G Procaine; Programmed Instructions as Topic; Rectum; Staining and Labeling; Syphilis; Tetracycline; Urethritis

Topics: Adult; Balanitis; Drug Eruptions; Humans; Male; Tetracycline; Urethritis

Topics: Acute Disease; Anti-Bacterial Agents; Chloramphenicol; Erythromycin; Gonorrhea; Humans; India; Leucomycins; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillin Resistance; Penicillins; Tetracycline; Urethritis

Topics: Ampicillin; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Prostate; Prostatitis; Semen; Tetracycline; Urethra; Urethritis

Topics: Chlamydia Infections; Female; Granuloma Inguinale; Humans; Lymphogranuloma Venereum; Male; Mycoplasma Infections; Proctitis; Sexually Transmitted Diseases; Tetracycline; Urethritis; Uterine Cervicitis; Vaginitis

Topics: Ampicillin; Australia; Culture Media; Drug Eruptions; Erythromycin; Gonorrhea; Humans; Kanamycin; Kidney; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Oxytetracycline; Penicillin G Benzathine; Penicillin G Procaine; Penicillin Resistance; Probenecid; Streptomycin; Tetracycline; Urethritis

Topics: Adult; Female; Hematuria; Humans; Leukocytes; Male; Mycoplasma Infections; Specimen Handling; Tetracycline; Urethra; Urethritis; Urinary Bladder

Topics: Adult; Complement Fixation Tests; Diagnosis, Differential; Humans; Male; Methods; Mycoplasma Infections; Respiratory Tract Infections; Tetracycline; Urethritis; Urinary Tract Infections

Topics: Administration, Oral; Diarrhea; Gonorrhea; Humans; Male; Nausea; New York City; Tetracycline; United States; Urethritis; Vomiting

Topics: Adult; Arthritis, Reactive; Culture Media; Erythromycin; Female; Humans; Male; Mycoplasma; Mycoplasma Infections; Prostatitis; Tetracycline; Urethritis; Urinary Tract Infections

Topics: Arthritis, Reactive; Chlamydia; Chlamydia Infections; Conjunctivitis, Inclusion; Female; Humans; Male; Sulfonamides; Tetracycline; Trachoma; United Kingdom; Urethritis; Uterine Cervicitis

Topics: Australia; Female; Fluorescent Antibody Technique; Gonorrhea; Humans; Male; Penicillins; Sex Factors; Sexually Transmitted Diseases; Syphilis; Syphilis Serodiagnosis; Syphilis, Congenital; Syphilis, Latent; Tetracycline; Urethritis

Topics: Acute Disease; Adult; Aged; Bacteria; Child; Cystitis; Epididymitis; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Penicillin Resistance; Penicillin V; Pyelonephritis; Tetracycline; Urethritis; Urinary Tract Infections

Topics: Ampicillin; Erythromycin; Gonorrhea; Humans; Penicillin Resistance; Penicillins; Tetracycline; Urethritis

Topics: Female; Gonorrhea; Humans; Male; Mycoplasma; Species Specificity; Tetracycline; Trichomonas Vaginitis; Urethritis

Topics: Adolescent; Adult; Gonorrhea; Humans; Male; Middle Aged; Phosphates; Tetracycline; Urethritis

Topics: Erythromycin; Humans; Lincomycin; Male; Mycoplasma; Tetracycline; Urethritis

Topics: Bacteriological Techniques; Drug Resistance, Microbial; Erythromycin; Humans; Lincomycin; Male; Mycoplasma; Mycoplasma Infections; Tetracycline; Urethra; Urethritis

Topics: Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Penicillin Resistance; Penicillins; Tetracycline; Urethritis

Topics: Adult; Humans; Male; Oleandomycin; Tetracycline; Urethritis

Topics: Erythromycin; Humans; Male; Mycoplasma; Tetracycline; Urethritis

Topics: Acne Vulgaris; Gonorrhea; Humans; Oleandomycin; Pyoderma; Skin Diseases; Steroids; Syphilis; Tetracycline; Urethritis

Topics: Diagnosis, Differential; Evaluation Studies as Topic; Gonorrhea; Humans; Male; Penicillins; Tetracycline; Urethritis

Topics: Adult; Female; Gonorrhea; Humans; Male; Mycoplasma; Naval Medicine; Neisseria gonorrhoeae; Penicillin G Procaine; Penicillin Resistance; Probenecid; Tetracycline; Urethritis

Topics: Adolescent; Adult; Gonorrhea; Humans; Inositol; Male; Middle Aged; Novobiocin; Tetracycline; Urethritis

Topics: Anti-Bacterial Agents; Biomedical Research; Chloramphenicol; Drug Therapy; Gonorrhea; Humans; Male; Penicillin G; Penicillin G Procaine; Procaine; Spectinomycin; Sulfates; Tetracycline; Urethritis

Topics: Anti-Bacterial Agents; Chloramphenicol; Drug Therapy; Epidemiology; Gonorrhea; Humans; Neisseria gonorrhoeae; Penicillin Resistance; Penicillins; South Africa; Streptomycin; Sulfanilamide; Sulfanilamides; Sulfonamides; Tetracycline; Urethritis

Topics: Humans; Lymecycline; Male; Tetracycline; Urethritis

Topics: Anti-Bacterial Agents; Chloramphenicol; Gonorrhea; Humans; Leucomycins; Male; Tetracycline; Urethritis

Topics: Anti-Bacterial Agents; Communicable Disease Control; Diagnosis, Differential; Drug Resistance; Drug Resistance, Microbial; Ethylenediamines; Gonorrhea; Humans; Mycoplasma; Penicillin G; Penicillin G Benzathine; Philippines; Sexually Transmitted Diseases; Tetracycline; Urethritis

Topics: Adolescent; Anti-Bacterial Agents; Drug Therapy; England; Gonorrhea; Naval Medicine; Penicillins; Statistics as Topic; Streptomycin; Sulfanilamide; Sulfanilamides; Sulfonamides; Tetracycline; Urethritis

Topics: Anti-Bacterial Agents; Biomedical Research; Blood; Double-Blind Method; Drug Therapy; Epididymitis; Geriatrics; Humans; Male; Pathology; Placebos; Postoperative Complications; Prostatectomy; Prostatic Hyperplasia; Pyelonephritis; Tetracycline; Urethritis; Urine

Topics: Actinomycosis; Actinomycosis, Cervicofacial; Ameloblastoma; Anti-Bacterial Agents; Chloramphenicol; Humans; Nitrofurantoin; Penicillin G; Penicillin V; Penicillins; Periapical Abscess; Postoperative Complications; Surgical Procedures, Operative; Tetracycline; Tooth Extraction; Urethritis

Topics: Anti-Bacterial Agents; Bartholin's Glands; Candidiasis; Chloramphenicol; Conjunctivitis; Ethylenediamines; Female; France; Gonorrhea; Humans; Imidazoles; Penicillin G; Penicillin G Benzathine; Penicillin G Procaine; Procaine; Spiramycin; Streptomycin; Tetracycline; Trichomonas Infections; Urethritis; Vulvovaginitis

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Dermatologic Agents; Humans; Male; Prostatitis; Protein Synthesis Inhibitors; Tetracycline; Trichomonas; Trichomonas Infections; Urethritis

Topics: Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Gonorrhea; Humans; Male; Tetracycline; Urethritis

Topics: Anti-Bacterial Agents; Demeclocycline; Humans; Protein Synthesis Inhibitors; Tetracycline; Urethritis

Topics: Anti-Bacterial Agents; Injections, Intramuscular; Oxytetracycline; Protein Synthesis Inhibitors; Tetracycline; Urethritis

Topics: Acute Disease; Anti-Bacterial Agents; Gonorrhea; Phosphates; Protein Synthesis Inhibitors; Tetracycline; Urethritis

Topics: Anti-Bacterial Agents; Phosphates; Protein Synthesis Inhibitors; Tetracycline; Urethritis

Topics: Anti-Bacterial Agents; Methylprednisolone; Prednisolone; Tetracycline; Urethritis

Topics: Anti-Bacterial Agents; Oleandomycin; Tetracycline; Urethritis

Topics: Anti-Bacterial Agents; Humans; Tetracycline; Urethritis

Topics: Anti-Bacterial Agents; Oleandomycin; Protein Synthesis Inhibitors; Tetracycline; Urethritis

Topics: Anti-Bacterial Agents; Humans; Oleandomycin; Tetracycline; Urethritis

Topics: Anti-Bacterial Agents; Humans; Male; Protein Synthesis Inhibitors; Tetracycline; Urethritis

Topics: Anti-Bacterial Agents; Erythromycin; Humans; Protein Synthesis Inhibitors; Tetracycline; Urethritis

Topics: Anti-Bacterial Agents; Humans; Protein Synthesis Inhibitors; Tetracycline; Urethritis