tetracycline and Urethral-Diseases

A proctocol to be administered by nurses for the management of dysuria, frequent urination, and vaginal discharge was validated. In a randomized, controlled trial, 146 women were seen by both nurse and physician and then assigned to either the nurse-proctocol treatment plan or the physician treatment plan. The clinical data collected by the nurse showed no important differences from the physicians' data. The protocol recommended that 89 percent of the patients be sent home without seeing the physician. The physicians agreed with the protocol-recommended disposition in all but two cases. All patients with complications were appropriately referred to the physician. In follow-up, more than 95 percent of both groups reported symptomatic improvement, and repeat urine cultures were negative. We conclude that the protocol can be accurately administered, makes sound recommendations, is safe, and efficiently saves physician time.

Topics: Adolescent; Adult; Ampicillin; Candidiasis, Vulvovaginal; Female; Humans; Nurses; Physicians; Sulfisoxazole; Syndrome; Tetracycline; Trichomonas Infections; Urethral Diseases; Urethritis; Urinary Tract Infections; Urination Disorders; Vagina; Vaginal Diseases; Vaginitis

The World Health Organization has proposed the syndromic approach for management of sexually transmissible diseases (STD) in countries where diagnostic laboratory tests are not consistently available. The purpose of this study was to evaluate the effectiveness of this approach for treatment of ureteral discharge in Senegal. Twenty seven men presenting ureteral discharge underwent two-week treatment using a combination of cotrimoxazole plus tetracycline for suspected gonococcal and a chlamydial infections. Ureteral samples were collected before and after treatment to detect Neisseria gonorrhoeae by culture and Chlamydia trachomatis by direct immunofluorescence and ELISA. Results demonstrated successful treatment of all patients presenting gonococcal and chlamydial infections i.e. 84.6% of cases. Neither germ was detected in 15.4% of cases. Before treatment, Neisseria gonorrhoeae, Chlamydia trachomatis or both were found respectively in 53.9%, 5.1% and 25.6% of samples respectively. Based on these findings we conclude that the syndromic approach was effective in 84.6% of cases but treatment was in adequation with STD biologically documented only with 25.6% of cases.

Topics: Anti-Bacterial Agents; Chlamydia Infections; Chlamydia trachomatis; Drug Therapy, Combination; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Senegal; Syndrome; Tetracycline; Trimethoprim, Sulfamethoxazole Drug Combination; Urethral Diseases

Sixty women with the diagnosis of urethral syndrome were consecutively assigned to one of three treatment modalities. The first group (20 patients) was treated with tetracycline, 2 g/d for ten days. The second group (20 patients) was treated with three serial urethral dilations at two- to three-week intervals, and the third group (20 patients) received placebo for ten days and served as a control group. A detailed clinical evaluation and uroflowmetry were performed before treatment and eight weeks afterwards. A subjective cure, which was defined as an absence of symptoms at the follow-up visits, was achieved in 20% of the placebo group, 50% of the tetracycline group and 75% of the urethral dilation group (P less than .01). An objective improvement in uroflowmetry occurred only in the group treated with serial urethral dilation.

Topics: Adult; Dilatation; Female; Follow-Up Studies; Humans; Middle Aged; Prospective Studies; Surveys and Questionnaires; Syndrome; Tetracycline; Urethral Diseases; Urination Disorders

During the last years Chlamydiae have been increasingly recognized as an important cause of urogenital infections. This paper is concerned with the classification, microbiology, cultivation and clinical findings of Chlamydiae, especially Chlamydia trachomatis, as causative agents of genital tract diseases.

Topics: Adult; Chlamydia Infections; Chlamydia trachomatis; Erythromycin; Female; Genital Diseases, Female; Humans; Male; Pregnancy; Tetracycline; Urethral Diseases

Topics: Administration, Oral; Gonorrhea; Homosexuality; Humans; Injections, Intramuscular; Male; Neisseria gonorrhoeae; Penicillin G Procaine; Pharyngeal Diseases; Pharynx; Prospective Studies; Rectal Diseases; Rectum; Surveys and Questionnaires; Tetracycline; Urethral Diseases

Topics: Cholinesterase Inhibitors; Coumarins; Dimenhydrinate; Female; Humans; Intestinal Obstruction; Methods; Postoperative Complications; Pyelitis; Pyelonephritis; Pyridostigmine Bromide; Tetracycline; Urethral Diseases; Urinary Catheterization; Urinary Fistula; Uterine Neoplasms; Vaginal Fistula