tetracycline and Typhus--Epidemic-Louse-Borne

Information about changes in the modern taxonomy of intracellular bacteria conditionally united within the nomination of "Rickettsioses" is presented in the paper. Due to a total hobby related with keeping home animals (pets), cats and dogs, apart from the cattle, joined the natural ecological cycles of rickettsioses stimulation. The morbidity of rickettsioses of the acaroid group has been persistently growing; like in case with other pathologies (Lyme's disease) involving the acaroid transfer factor, its obvious "urbanization" is pronounced. Absolute and relative morbidity indices in respect to rickettsioses, which are epidemiologically important for Russia, are presented. The modern knowledge database concerning the rickettsioses makes it possible to control the epidemic process for this infection category. It is noteworthy, that Prowazek's rickettsiosis of its both forms (i.e. the epidemic and relapsing ones), which does not have an independent cycle of circulation of its stimulator in wild nature, and unlike the acaroid group rickettsioses, turned into a socially controllable infection. It will be totally eliminated, during 10-15 years, both in Russia and the CIS countries. The practitioners are well supplied with a variety of drugs of tetracycline and fluorine-quinol groups, which makes it possible to arrest the infection process in patients rapidly and effectively and to prevent the lethal cases. A low incidence rate of rickettsioses, including Q fever, within the general infection morbidity, and taking into consideration the availability of methods for effective therapy and prevention, makes one consider a comprehensive vaccination against the discussed group of infections to be irrational. Obviously, such vaccination must be still applied in respect to a limited number of persons from among high-risk groups and for two or three varieties of rickettsioses only (i.e. Prowazek's rickettsioses, Rocky Mountain spotted fever and Q fever). Live vaccines, obtained on the basis of attenuated and recombined strains (which have a full-scale set of specific antigens), are recommended.

Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Vaccines; Cats; Cattle; Dogs; Fluoroquinolones; Humans; Immunization; Q Fever; Rickettsia; Rickettsia Infections; Rickettsia prowazekii; Rocky Mountain Spotted Fever; Russia; Tetracycline; Typhus, Epidemic Louse-Borne

Topics: Anti-Bacterial Agents; Humans; Prognosis; Rickettsia prowazekii; Serologic Tests; Tetracycline; Typhus, Epidemic Louse-Borne

Topics: Amantadine; Antiviral Agents; Chloramphenicol; Cytarabine; Cytomegalovirus Infections; Erythromycin; gamma-Globulins; Herpes Simplex; Herpes Zoster; Humans; Idoxuridine; Influenza, Human; Interferons; Mycoplasma Infections; Poxviridae Infections; Q Fever; Rickettsia Infections; Rocky Mountain Spotted Fever; Tetracycline; Thiosemicarbazones; Typhus, Epidemic Louse-Borne; Virus Diseases

Topics: Anti-Bacterial Agents; Disease Outbreaks; Female; Hospitals, Psychiatric; Humans; Russia; Tetracycline; Typhus, Epidemic Louse-Borne

Meningitis is an unusual presentation of rickettsial infection. We report a patient who was confirmed by serology to have typhus fever (not scrub), but who presented with the typical findings of culture-negative bacterial meningitis. Neurological manifestations of different types of rickettsial infection are discussed.

Topics: Chloramphenicol; Diagnosis, Differential; Humans; Male; Meningitis; Middle Aged; Tetracycline; Typhus, Epidemic Louse-Borne

The effect of doxycycline on R. prowazekii and R. sibirica was studied in comparison with that of tetracycline on two infection models, i. e. chick embryos and guinea pigs. The activity of doxycycline in the experiments with chick embryos was higher than that of tetracycline, the drug being more active against R. prowazekii than R. sibirica. The use of doxycycline in the treatment of the guinea pigs infected with R. prowazekii resulted in very rapid and stable decrease of the temperature. When used within the incubation period the drug prevented the infection development. Doxycycline was less effective in infections caused by R. sibirica.

Topics: Animals; Antibodies, Bacterial; Chick Embryo; Doxycycline; Drug Evaluation, Preclinical; Guinea Pigs; Rickettsia; Rickettsia Infections; Rickettsia prowazekii; Tetracycline; Time Factors; Typhus, Epidemic Louse-Borne

Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Chloramphenicol; Doxycycline; Ethiopia; Humans; Insect Vectors; Middle Aged; Phthiraptera; Tetracycline; Typhus, Epidemic Louse-Borne

Topics: Animals; Antibody Formation; Body Temperature; Complement Fixation Tests; Guinea Pigs; Rifampin; Tetracycline; Time Factors; Typhus, Epidemic Louse-Borne

This report documents the occurrence of Brill-Zinsser disease in a 48-year-old woman who experienced typhus fever in a German concentration camp. This is the first report of a case of recrudescent typhus in a European immigrating to Canada following World War II. The last reported case of Brill-Zinsser disease in Canada occurred in 1953.

Topics: Canada; Diagnosis, Differential; Female; Humans; Jews; Middle Aged; Recurrence; Salmonella Infections; Syndrome; Tetracycline; Typhus, Epidemic Louse-Borne

Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Blood Platelet Disorders; Body Temperature; Complement Fixation Tests; Disease Outbreaks; Female; Fluorescent Antibody Technique; Gastrointestinal Hemorrhage; Humans; Israel; Male; Middle Aged; Tetracycline; Ticks; Typhus, Endemic Flea-Borne; Typhus, Epidemic Louse-Borne

Topics: Adult; Aged; Chloramphenicol; Complement Fixation Tests; DDT; Disease Outbreaks; Housing; Humans; Lice Infestations; Refugees; Rural Population; Rwanda; Tetracycline; Typhus, Epidemic Louse-Borne; Uganda

Topics: Adolescent; Adult; Child; Child, Preschool; Dysentery, Bacillary; Enterocolitis, Pseudomembranous; Humans; Infant; Male; Middle Aged; Respiratory Tract Infections; Tetracycline; Typhus, Epidemic Louse-Borne

Topics: Adult; Bacterial Vaccines; Female; Humans; Laboratory Infection; Liver; Male; Oxytetracycline; Tetracycline; Typhus, Epidemic Louse-Borne

Topics: Anti-Bacterial Agents; Humans; Tetracycline; Typhus, Epidemic Louse-Borne

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Brucellosis; Chloramphenicol; Prednisone; Steroids; Tetracycline; Typhoid Fever; Typhoid-Paratyphoid Vaccines; Typhus, Epidemic Louse-Borne

Topics: Anti-Bacterial Agents; Humans; Protein Synthesis Inhibitors; Tetracycline; Typhus, Epidemic Louse-Borne