tetracycline and Tooth-Mobility

In a comparative evaluation of the effectiveness of two treatment modalities for juvenile periodontitis, 12 patients aged between 15 years and 23 years were recruited into a six months longitudinal study. The split mouth design was used such that one side (upper and lower quadrants) received conservative treatment. Each side was randomly assigned one of the two treatment modalities. Standardized probing attachment level (PAL) measurement and degree of mobility of the teeth were taken at recruitment (baseline), one, three and six months postoperation. Tetracycline capsules 250mg, 6 hourly, was administered for 2 weeks at baseline and at 3 months follow-up. Initial thorough scaling and polishing of the whole mouth was done for all the patients. At follow-up, there were marked improvements seen with both treatment modalities. The mean probing depth for surgical treatment (3.57mm +/- 0.78) was significantly lower than that of conservative treatment (4.11mm +/- 0.74) P < 0.05 at 3 months. Also, this significant difference continued up to 6 months (2.70mm +/- 0.57, 3.55mm +/- 0.65; P < 0.05 ). For the degree of mobility, significant difference was only evident at 6 months of follow-up (0.48 +/- 0.29, 0.98 +/- 0.523; P < 0.05 ) for surgical treatment and conservative treatment respectively. It was therefore concluded that surgical debridement with systemic administration of tetracycline is more effective than the conservative technique in the treatment of juvenile periodontitis, although both gave improvement.

Topics: Adolescent; Adult; Age Factors; Aggressive Periodontitis; Analysis of Variance; Anti-Bacterial Agents; Debridement; Female; Humans; Longitudinal Studies; Male; Periodontal Attachment Loss; Periodontal Index; Random Allocation; Tetracycline; Tooth Mobility

The purpose was to evaluate the use of demineralized freeze-dried bone allograft reconstituted with 50 mg/ml tetracycline hydrochloride in the treatment of intrabony periodontal defects. Fifteen systemically healthy patients (12 females, 3 males; aged 35 to 61) with moderate-advanced periodontitis were treated. Patients had 3 osseous defects with probing depths (PD) > 5 mm after initial therapy. Each site in each subject was randomly assigned to one of the following groups: 1) demineralized freeze-dried bone allograft reconstituted with 50 mg/ml tetracycline (DFDBA + TCN); 2) demineralized freeze-dried bone allograft alone (DFDBA); or 3) debridement only (D). Clinical measurements were taken the day of surgery, 6 months, and 1 year. Standardized radiographs were taken at baseline and 1 year and were evaluated by computer assisted densitometric image analysis (CADIA). Clinical measurements included gingival recession, PD, clinical attachment level, and mobility. Osseous defect measurements were taken at baseline and at the 1 year reentry. No adverse healing responses occurred. The results showed that all patients had a statistically significant improvement in probing depth and attachment level at 1 year. Osseous measurements showed bone fill of 2.27 mm (51.6%) for the DFDBA + TCN group, 2.20 mm (52.4%) for the DFDBA group, and 1.27 mm (32.8%) for the D group. Defect resolution was 77.3% for the DFDBA + TCN group, 77.9% for the DFDBA group, and 63.8% for the D group. The mean CADIA values were 5.04 for the DFDBA + TCN group, 6.79 for the DFDBA group and 2.78 for the D group. The CADIA values did not correlate with the clinical parameters. Although the grafted groups showed greater bone fill and defect resolution, there was no statistically significant difference in any of the clinical parameters between the treatment groups. This study suggests that there is no significant benefit from reconstituting the allograft with 50 mg/ml of tetracycline hydrochloride.

Topics: Absorptiometry, Photon; Adult; Alveolar Bone Loss; Anti-Bacterial Agents; Bone Transplantation; Debridement; Decalcification Technique; Female; Follow-Up Studies; Freeze Drying; Gingival Recession; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Periodontal Attachment Loss; Periodontal Pocket; Periodontitis; Tetracycline; Tooth Mobility; Transplantation, Homologous; Wound Healing

The purpose of this study was to assess the clinical and microbiological effects of a newly developed root conditioning gel system containing tetracycline or a mixture of tetracycline and citric acid on non-surgical periodontal therapy. Sixty-four (64) single-rooted teeth with a probing depth of 4 to 6 mm were randomly subjected to one of the following four treatments; 1) root planing alone (RP group); 2) tetracycline-containing gel alone (TCG group); 3) root planing plus tetracycline-containing gel (RP + TCG group); or 4) root planing plus a mixture of tetracycline and citric acid-containing gel (RP + TC-CAG group). Probing depth, attachment level, and tooth mobility were measured and the presence of dental plaque and gingival inflammation was recorded at baseline and after 2, 4, 8, and 12 weeks. Subgingival plaque samples from each site were collected at the same visits and examined with phase contrast microscopy for proportions of motile rods and spirochetes. Plaque index, gingival sulcus bleeding index (SBI), probing depth, and attachment level decreased significantly in all groups compared to the baseline values (P < 0.05). A significant decrease in probing pocket depth was noted after 12 weeks in RP + TC-CAG group compared to the other groups (P < 0.05). Significantly more gain in attachment was detected in the RP + TC-CAG group compared to the TCG group (P < 0.05). Tooth mobility scores also decreased later in the study. A significant decrease in the proportion of motile rods was found primarily in the RP + TC-CAG group.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Adult; Bacteria; Citrates; Citric Acid; Colony Count, Microbial; Combined Modality Therapy; Dental Plaque; Dental Plaque Index; Drug Combinations; Female; Gels; Gingival Hemorrhage; Gingivitis; Humans; Male; Middle Aged; Periodontal Diseases; Periodontal Index; Periodontal Pocket; Root Planing; Spirochaetales; Tetracycline; Tooth Mobility

Individuals with Down syndrome (DS) are susceptible to severe periodontal disease, due to immune alterations related to functional defects of polymorphonuclear leukocytes and monocytes. The adjunctive use of locally delivered antimicrobials has been proven to be beneficial, especially in areas where mechanical therapy might fail. This article describes the management of a patient with DS who had aggressive periodontitis. The treatment used a local drug delivery system with tetracycline fibers as an adjunct to scaling and root planing.

Topics: Adult; Aggressive Periodontitis; Alveolar Bone Loss; Anti-Bacterial Agents; Collagen; Combined Modality Therapy; Dental Plaque Index; Dental Scaling; Down Syndrome; Drug Carriers; Drug Delivery Systems; Female; Follow-Up Studies; Furcation Defects; Humans; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Root Planing; Tetracycline; Tooth Mobility

Topics: Adult; Anti-Bacterial Agents; Combined Modality Therapy; Dental Scaling; Follow-Up Studies; Guided Tissue Regeneration, Periodontal; Humans; Incisor; Male; Mandible; Periodontal Diseases; Postoperative Period; Radiography; Tetracycline; Tooth Mobility

A pathologically migrated maxillary central incisor tooth with a poor periodontal prognosis was treated successfully with conventional periodontal therapy. After almost 4 years, an extensive periodontal lesion developed on the same tooth and extraction was recommended. The patient did not comply and the acute symptoms disappeared after the administration of 1 gm of Tetracycline a day for 2 weeks. Although no definitive periodontal therapy was done, complete resolution of the lesion occurred with the healing of the structures of the periodontium and a dramatic reduction in mobility of the tooth. Antibacterial therapy could be an effective means of treating some periodontal lesions once a more exact and direct association is established between the various clinical forms of periodontitis and specific periodontal or groups of pathogens.

Topics: Female; Humans; Incisor; Middle Aged; Periodontitis; Recurrence; Tetracycline; Tooth Migration; Tooth Mobility

Topics: Alveolar Process; Animals; Bone Regeneration; Collagen; Elastic Tissue; Gingivectomy; Haplorhini; Orthodontic Appliances; Orthodontics, Corrective; Periodontium; Tetracycline; Tooth Mobility; Tooth Resorption; Tooth Root

Topics: Alveolar Process; Animals; Bicuspid; Bone Development; Cats; Cuspid; Maxilla; Microscopy, Fluorescence; Orthodontic Appliances; Orthodontics, Corrective; Pressure; Tetracycline; Tooth Mobility