tetracycline and Tetanus

Topics: Calcium Chloride; Carbon Dioxide; Debridement; Diagnosis, Differential; Epinephrine; Heart Arrest; Humans; Hydrogen Peroxide; Hypnotics and Sedatives; Immunoglobulins; Immunotherapy; Intensive Care Units; Metabolic Diseases; Oxygen; Penicillins; Positive-Pressure Respiration; Spasm; Tetanus; Tetanus Antitoxin; Tetracycline; Tracheotomy; Urban Population; Wounds and Injuries

Topics: Analgesics; Analgesics, Non-Narcotic; Anticonvulsants; Antipyretics; Bandages; Bismuth; Cosmetics; Drug Therapy; Facial Paralysis; Humans; Migraine Disorders; Monoamine Oxidase Inhibitors; Neuralgia; Nystatin; Oxytetracycline; Shoes; Surgical Equipment; Suture Techniques; Tetanus; Tetanus Toxoid; Tetracycline; Trigeminal Neuralgia; Weights and Measures

Topics: Adult; Female; Humans; Tetanus; Tetanus Antitoxin; Tetracycline; Time Factors

The effect of tetracycline and oleandomycin on the complement titer, lysozyme content, serum bactericidal properties and presence of specific antibiotic antibodies in the blood serum was studied. The latter were shown with the Hoigné reaction under conditions of aseptic inflammation caused against the background of latent tetanus intoxication. It was shown that tetracycline and oleandomycin used in treatment of the animals with aseptic inflammation developed at the background of latent tatanus intoxication induced an increased in the complement titer, lysozyme content and bactericidal properties of the serum. Reduction of the above indices was observed by the 15th-20th day after discontinuation of the drug use. The increase in the factors of non-specific immunity under the effect of tetracycline and oleandomycin in the animals with aseptic inflammation caused against the background of latent tetanus intoxication was accompanied by appearance in the blood serum on non-specific antibodies revealed with the Hoigné reaction. Changed reactivity because of latent tetanus intoxication was accompanied by a delay in the formation of the non-specific antibodies in the blood serum. However, later the rate of their accumulation became higher and as a result the maximum titers of the antibodies were 2-3 times higher than those in the control animals.

Topics: Animals; Antibody Specificity; Antigen-Antibody Reactions; Blood Bactericidal Activity; Complement Fixation Tests; Immunity; Inflammation; Muramidase; Oleandomycin; Rabbits; Tetanus; Tetracycline; Time Factors

Topics: Animals; Anti-Bacterial Agents; Immunity; Injections, Subcutaneous; Mice; Penicillins; Premedication; Streptomycin; Tetanus; Tetanus Toxin; Tetracycline; Time Factors

Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Brain Injuries; Bronchi; Cerebrovascular Disorders; Female; Humans; Male; Middle Aged; Postoperative Care; Tetanus; Tetracycline; Tracheotomy

Topics: Animals; Clostridium; Clostridium perfringens; Clostridium tetani; Gas Gangrene; Metronidazole; Mice; Penicillin G; Tetanus; Tetracycline

Topics: Adult; Aged; Amobarbital; Child; Chloramphenicol; Humans; Middle Aged; Neostigmine; Oxytetracycline; Phenytoin; Tetanus; Tetanus Antitoxin; Tetanus Toxoid; Tetracycline; Wound Infection; Wounds and Injuries

Topics: Animals; Female; Hyperbaric Oxygenation; Mice; Tetanus; Tetracycline

Topics: Cortisone; gamma-Globulins; Humans; Monitoring, Physiologic; Penicillins; Tetanus; Tetanus Antitoxin; Tetanus Toxoid; Tetracycline; Tracheotomy

Topics: Animals; Bacteriolysis; gamma-Globulins; Guinea Pigs; Penicillin G Procaine; Tetanus; Tetanus Antitoxin; Tetracycline; Toxins, Biological

Topics: Humans; Penicillins; Tetanus; Tetanus Antitoxin; Tetanus Toxoid; Tetracycline; Wound Infection

Topics: Anti-Bacterial Agents; Debridement; Humans; Penicillins; Preventive Medicine; Protein Synthesis Inhibitors; Tetanus; Tetanus Antitoxin; Tetanus Toxoid; Tetracycline; Wounds and Injuries

Topics: Anti-Bacterial Agents; Female; Humans; Penicillins; Pregnancy; Protein Synthesis Inhibitors; Tetanus; Tetanus Antitoxin; Tetanus Toxoid; Tetracycline

Topics: Anti-Bacterial Agents; Physiology; Protein Synthesis Inhibitors; Tetanus; Tetanus Toxoid; Tetracycline

Topics: Anaphylaxis; Anti-Bacterial Agents; Child; Debridement; Humans; Ireland; Penicillins; Protein Synthesis Inhibitors; Serum Sickness; Tetanus; Tetanus Antitoxin; Tetanus Toxoid; Tetracycline; Toxicology

Topics: Anti-Bacterial Agents; Benzodiazepines; Chlorpromazine; Diazepam; Drug Therapy; Erythromycin; Humans; Meprobamate; Penicillins; Promethazine; Protein Synthesis Inhibitors; Tetanus; Tetanus Toxoid; Tetracycline

Topics: Anti-Bacterial Agents; Child; Chlorpromazine; Humans; Immunization, Passive; India; Infant; Infant Mortality; Infant, Newborn; Infant, Newborn, Diseases; Paraldehyde; Phenobarbital; Prednisolone; Statistics as Topic; Tetanus; Tetanus Toxoid; Tetracycline

Topics: Anaphylaxis; Anti-Bacterial Agents; Eye Injuries; Humans; Hypersensitivity; Immunization Schedule; Ophthalmology; Penicillins; Serum Sickness; Tetanus; Tetanus Antitoxin; Tetanus Toxoid; Tetracycline

Cleansing and debridement is paramount in dealing with tetanus-prone wounds (severe crushing injuries, piercing wounds, blisters and burns are outstanding examples, particularly if contaminated with dirt, grass or other debris). Prophylaxis then is relatively easy in persons who have been actively immunized by toxoid injections. For them, a "booster" injection is indicated. Use of antitoxin, however, is hazardous, whether for prophylaxis or for treatment of the disease. Since it may in itself cause severe disease, including anaphylactic reaction and serum sickness, decision to use it must be weighed against the possibility of the development of tetanus in each case. To prepare for use of it, careful history should be taken, with particular reference to sensitivity to horse dander. Dermal tests, and perhaps ophthalmic tests, for sensitivity to the serum should be carried out. Even the tests may be hazardous and precautions should be taken accordingly. If it is decided that the use of antitoxin is necessary even though the patient is sensitive to the material, desensitization must be carried out promptly, with adequate preparation for severe reaction. There is experimental evidence that antibiotics of the tetracycline group, given soon after injury, may have prophylactic effect against tetanus.

Topics: Anaphylaxis; Anti-Bacterial Agents; Antitoxins; Burns; Debridement; Humans; Immunization; Serum Sickness; Tetanus; Tetanus Toxoid; Tetracycline; Vaccination

Topics: Anti-Bacterial Agents; Cornea; Corneal Diseases; Disease; Humans; Tetanus; Tetracycline

Topics: Anti-Bacterial Agents; Humans; Tetanus; Tetracycline; Tetracyclines