tetracycline and Testicular-Diseases

To compare the effects and side-effects of polidocanol and tetracycline when used as sclerosants for testicular hydrocele and epididymal cyst.. Forty-five men (median age 67 years, range 42-81) with 46 hydroceles or epididymal cysts were assessed. After puncture and aspiration, the empty sac was instilled with either polidocanol or tetracycline, assigned randomly. Patients recorded any treatment-associated pain on a visual analogue scale.. At 9 months of follow-up, nine of 17 men were cured after sclerotherapy with polidocanol compared with 17 of 20 men treated with tetracycline (P < 0.05). Tetracycline produced some pain for 3 days after treatment while polidocanol therapy was almost pain-free. Re-instillation should be considered for recurrences. At the follow-up after 35 months, 16 of 18 men treated with polidocanol and 20 of 22 men treated with tetracycline were satisfied with the outcome.. Both polidocanol and tetracycline are useful sclerosants for treating testicular hydrocele and epididymal cyst. We prefer polidocanol as a first choice in older patients because there were few short-term side-effects.

Topics: Adult; Aged; Aged, 80 and over; Cysts; Follow-Up Studies; Humans; Male; Middle Aged; Patient Satisfaction; Polidocanol; Polyethylene Glycols; Sclerosing Solutions; Sclerotherapy; Testicular Diseases; Testicular Hydrocele; Tetracycline; Treatment Outcome

Topics: Aged; Clinical Trials as Topic; Cysts; Humans; Male; Middle Aged; Prospective Studies; Sclerosing Solutions; Testicular Diseases; Testicular Hydrocele; Tetracycline

Tetracycline, a broad-spectrum antibiotic employed clinically in the treatment of bacteria infections, is known to cause a number of biochemical dysfunctions and suspected to induce testicular damage to animals and humans, but there is paucity of data on its effect and mechanism of action on the male reproductive system. The present study therefore evaluates its spermatotoxic and testicular toxicity in male rats and the chemoprotective effects of Vitamin C (Vit C) and N-acetylcysteine (NAC). Tetracycline was administered orally at the dose level of 28.6 mg/kg body weight per day in two equal divided doses (12h interval). Vit C and NAC were also administered orally to the rats at doses of 200 and 50 mg/kg body weight per day, respectively, for the 14 days of the experiment. While there was no change in the body weights of rats, tetracycline administration caused significant decrease in the relative weights of testis, epididymis and seminal vesicles (P<0.05). Administration of tetracycline caused a reduction in the epididymal sperm motility, percentage of live spermatozoa, sperm count, and an increase in abnormal sperm morphology, as well as induction of adverse histopathologic changes in the testes. While Vit C and NAC significantly mitigated the toxic effect of tetracycline on sperm parameters, the antioxidants did not improve the adverse histopathologic changes induced by antibiotic. Treatment of rats with tetracycline significantly decreased the activities of superoxide dismutase, catalase (CAT), glucose-6-phosphate dehydrogenase, glutathione-S-transferase (GST) and the levels of GSH and serum testosterone, while the activity of gamma-glutamyltranspeptidase and the formation of malondialdehyde (MDA) increased. Both Vit C and NAC significantly attenuated the toxic effects of tetracycline to the antioxidant and testicular marker enzymes as well as markers of oxidative stress. Collectively, the results suggest that therapeutic dose of tetracycline elicits spermatotoxic and testicular toxicity in male rats through induction of oxidative stress. The chemoprotective effects of Vit C and NAC during tetracycline treatment suggest that these antioxidants may find clinical application in cellular damage involving reactive oxygen species (ROS).

Topics: Acetylcysteine; Administration, Oral; Animals; Anti-Bacterial Agents; Ascorbic Acid; Catalase; Drug Therapy, Combination; Free Radical Scavengers; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Transferase; Male; Organ Size; Oxidative Stress; Rats; Sperm Count; Sperm Motility; Spermatozoa; Superoxide Dismutase; Testicular Diseases; Testis; Testosterone; Tetracycline

Aspiration and tetracycline (Achromycin) instillation has been used to sclerose 'scrotal cysts'. Thirteen hydroceles and epididymal cysts were treated. Of the cysts treated, four failed to sclerose, and moderate to severe pain occurred in eight patients. In three patients the pain was severe, necessitating admission to the hospital. We would not recommend this treatment either in terms of efficacy or for patient comfort.

Topics: Adult; Aged; Ambulatory Care; Cysts; Epididymis; Evaluation Studies as Topic; Humans; Male; Middle Aged; Pain; Sclerotherapy; Testicular Diseases; Testicular Hydrocele; Tetracycline

Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Humans; Male; Middle Aged; Sclerotherapy; Testicular Diseases; Testicular Hydrocele; Tetracycline

Eleven cases of hydrocele testis were treated with injection of a 1% or 2% dedoxycycline hydrochloride or minocycline hydrochloride, and a cure was obtained in 9 cases (81.8%). Of these 9 cases, 7 cases were cured after one injection, and 2 cases after 2 injection. Both of the latter 2 cases in which physiological salt solution was used as the dissolving solution experienced scrotal pain immediately after injection. Among the cases in which 1% lidocaine was used as the dissolving solution only 1 injection (11.1%) was associated with slight pain out of 9 injections. This treating method is highly effective and little or no pain is experienced if lidocaine is used. In conclusion, we recommend this method as a treatment for hydrocele testis.

Topics: Adult; Aged; Humans; Lidocaine; Male; Middle Aged; Sclerosing Solutions; Testicular Diseases; Testicular Hydrocele; Tetracycline

In a prospective study 27 hydroceles were treated with single aspiration and injection of 500 mg tetracycline. The median observation period was 6 months (range 3-15 months). One month after therapy 9 recurrences were observed; but 5 disappeared spontaneously during the next 2 months, giving an overall success rate of 85% (95% confidence limits 66-96%). No serious complications occurred. Dilution of tetracycline in lidocaine prevented acute scrotal pain. Sclerotherapy with tetracycline is efficient, easy and inexpensive and, therefore, economical and beneficial for the patient.

Topics: Adult; Aged; Aged, 80 and over; Humans; Male; Middle Aged; Prospective Studies; Sclerosing Solutions; Suction; Testicular Diseases; Testicular Hydrocele; Tetracycline

Tetracycline (Achromycin, Lederle) solution was used to produce sclerosis of 37 hydroceles and 18 epididymal cysts in patients over the age of 50 years. All but one of the epididymal cysts were sclerosed satisfactorily at 9 months; 35 hydroceles sclerosed satisfactorily, although four patients required re-treatment at 3 months. One patient required orchiectomy for an infected haematocele. Pain after instillation of tetracycline was an occasional complication which could be prevented by prophylactic spermatic cord block. Tetracycline sclerotherapy is a safe and effective alternative to surgery for hydroceles and epididymal cysts in older patients.

Topics: Aged; Cysts; Epididymis; Humans; Male; Middle Aged; Sclerosing Solutions; Testicular Diseases; Testicular Hydrocele; Tetracycline

Topics: Aged; Humans; Male; Middle Aged; Testicular Diseases; Testicular Hydrocele; Tetracycline

Testicular hydroceles recurred within 6 months in 7 of 15 patients (46.7%) treated by aspiration and instillation of tetracycline. There was objective reduction in the size of the hydrocele in three patients (20%) but only five (33.3%) were cured. Severe pain was a complication in seven cases. This form of treatment is not recommended.

Topics: Aged; Humans; Instillation, Drug; Male; Recurrence; Suction; Testicular Diseases; Testicular Hydrocele; Tetracycline

Ten males over the age of 60 with primary hydrocele of the testis were treated by aspiration and injection of tetracycline. Nine were cured and one patient had a small recurrence but was satisfied with the result. There were no cases of haematoma or infection. We recommend this method since it can be carried out as an out-patient procedure with minimal side effects and at low cost.

Topics: Aged; Humans; Male; Middle Aged; Prospective Studies; Recurrence; Sclerosing Solutions; Suction; Testicular Diseases; Testicular Hydrocele; Tetracycline

Topics: Anesthesia, Local; Codeine; Epididymitis; Hematoma; Humans; Lidocaine; Male; Methylprednisolone; Postoperative Complications; Testicular Diseases; Tetracycline; Vasectomy