tetracycline and Syndrome

Because minocycline can cause serious adverse events including hypersensitivity syndrome reaction (HSR), serum sicknesslike reaction (SSLR), and drug-induced lupus, a follow-up study based on a retrospective review of our Drug Safety Clinic and the Health Protection Branch databases and a literature review was conducted to determine if similar rare events are associated with tetracycline and doxycycline. Cases of isolated single organ dysfunction (SOD) attributable to the use of these antibiotics also were identified.. Nineteen cases of HSR due to minocycline, 2 due to tetracycline, and 1 due to doxycycline were identified. Eleven cases of SSLR due to minocycline, 3 due to tetracycline, and 2 due to doxycycline were identified. All 33 cases of drug-induced lupus were attributable to minocycline. Forty cases of SOD from minocycline, 37 cases from tetracycline, and 6 from doxycycline were detected. Hypersensitivity syndrome reaction, SSLR, and SOD occur on average within 4 weeks of therapy, whereas minocycline-induced lupus occurs on average 2 years after the initiation of therapy.. Early serious events occurring during the course of tetracycline antibiotic treatment include HSR, SSLR, and SOD. Drug-induced lupus, which occurs late in the course of therapy, is reported only with minocycline. We theorize that minocycline metabolism may account for the increased frequency of serious adverse events with this drug.

Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Anti-Bacterial Agents; Arthralgia; Canada; Databases as Topic; Doxycycline; Drug Eruptions; Drug Hypersensitivity; Drug Prescriptions; Female; Fever; Follow-Up Studies; Humans; Liver; Lupus Erythematosus, Systemic; Male; Middle Aged; Minocycline; Retrospective Studies; Safety; Serum Sickness; Syndrome; Tetracycline; Time Factors

Two cases of yellow nail syndrome (a triad of yellow dystrophic nails, chronic lymphedema and pleural effusion) are described which demonstrate long-term control of recurrent pleural effusions by tetracycline pleurodesis. Neither patient developed problems as a result of the procedure enabling us to conclude that tetracycline pleurodesis is effective in managing reaccumulating pleural fluid in yellow nail syndrome and may avoid loss of lung function due to pleural peel.

Topics: Aged; Chronic Disease; Female; Follow-Up Studies; Humans; Lymphedema; Male; Middle Aged; Nail Diseases; Pleural Effusion; Pleurodesis; Syndrome; Tetracycline

A proctocol to be administered by nurses for the management of dysuria, frequent urination, and vaginal discharge was validated. In a randomized, controlled trial, 146 women were seen by both nurse and physician and then assigned to either the nurse-proctocol treatment plan or the physician treatment plan. The clinical data collected by the nurse showed no important differences from the physicians' data. The protocol recommended that 89 percent of the patients be sent home without seeing the physician. The physicians agreed with the protocol-recommended disposition in all but two cases. All patients with complications were appropriately referred to the physician. In follow-up, more than 95 percent of both groups reported symptomatic improvement, and repeat urine cultures were negative. We conclude that the protocol can be accurately administered, makes sound recommendations, is safe, and efficiently saves physician time.

Topics: Adolescent; Adult; Ampicillin; Candidiasis, Vulvovaginal; Female; Humans; Nurses; Physicians; Sulfisoxazole; Syndrome; Tetracycline; Trichomonas Infections; Urethral Diseases; Urethritis; Urinary Tract Infections; Urination Disorders; Vagina; Vaginal Diseases; Vaginitis

Topics: Cytoplasm; Female; Humans; Lysosomes; Microscopy, Electron; Middle Aged; Pigmentation; Syndrome; Tetracycline; Thyroid Diseases; Thyroid Gland

Recurrent or persistent follicular dysplasia and interface dermatitis are described in nine Boxers. Data on age, sex, seasonality of alopecia and histopathological features of the follicular dysplasia in these nine Boxers are comparable with those described in previous reports. The interface dermatitis was characterized by multifocal annular crusted lesions confined to the areas of follicular dysplasia. The inflammatory lesions were neither pruritic nor painful and affected dogs were otherwise healthy. Histopathologically the clinically inflammatory lesions were characterized as an interface dermatitis. Immunohistochemical studies failed to demonstrate immunoglobulins or complement at the basement membrane zone or within blood vessel walls. In dogs with recurrent or persistent disease, the follicular dysplasia and interface dermatitis ran identical, concurrent courses of spontaneous remission and recurrence, or persistence, respectively. One dog with persistent disease was treated successfully with tetracycline and niacinamide for the interface dermatitis, and melatonin for the follicular dysplasia. Although the aetiopathogenesis of this newly described condition and the relationship between the two histological reaction patterns are not known, photoperiod and genetic predisposition appear to play a role.

Topics: Animals; Dermatitis; Dog Diseases; Dogs; Female; Folliculitis; Immunohistochemistry; Male; Niacinamide; Physical Examination; Syndrome; Tetracycline

The World Health Organization has proposed the syndromic approach for management of sexually transmissible diseases (STD) in countries where diagnostic laboratory tests are not consistently available. The purpose of this study was to evaluate the effectiveness of this approach for treatment of ureteral discharge in Senegal. Twenty seven men presenting ureteral discharge underwent two-week treatment using a combination of cotrimoxazole plus tetracycline for suspected gonococcal and a chlamydial infections. Ureteral samples were collected before and after treatment to detect Neisseria gonorrhoeae by culture and Chlamydia trachomatis by direct immunofluorescence and ELISA. Results demonstrated successful treatment of all patients presenting gonococcal and chlamydial infections i.e. 84.6% of cases. Neither germ was detected in 15.4% of cases. Before treatment, Neisseria gonorrhoeae, Chlamydia trachomatis or both were found respectively in 53.9%, 5.1% and 25.6% of samples respectively. Based on these findings we conclude that the syndromic approach was effective in 84.6% of cases but treatment was in adequation with STD biologically documented only with 25.6% of cases.

Topics: Anti-Bacterial Agents; Chlamydia Infections; Chlamydia trachomatis; Drug Therapy, Combination; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Senegal; Syndrome; Tetracycline; Trimethoprim, Sulfamethoxazole Drug Combination; Urethral Diseases

Haemophilus somnus was consistently isolated from vaginal discharges of dairy cows submitted from field cases of vaginitis, cervicitis and/or metritis in the KwaZulu-Natal Midlands during the period July 1995 - December 2000 and from the East Griqualand area in November/December 2000. The purulent vaginal discharges, red granular vaginitis and cervicitis, and pain on palpation described in these cases was very similar to that reported in outbreaks of H.somnus endometritis syndrome in Australia, Europe and North America. In all the herds involved in these outbreaks, natural breeding with bulls was employed. Although there was a good cure rate in clinically-affected animals treated with tetracyclines, culling rates for chronic infertility were unacceptably high. Employment of artificial insemination in these herds improved pregnancy rates in cows that had calved previously, but many cows that had formerly been infected failed to conceive.

Topics: Animals; Breeding; Cattle; Cattle Diseases; Disease Outbreaks; Endometritis; Female; Haemophilus; Haemophilus Infections; Infertility, Female; Insemination, Artificial; Male; Pregnancy; Pregnancy Rate; South Africa; Syndrome; Tetracycline; Uterine Cervicitis; Vaginitis

A 48-year-old woman, who had undergone reversal of a jejunal loop, presented with skin eruptions, myalgia and arthralgia. Delayed gastric emptying was associated with a gastric phytobezoar. The clinicopathological features and response to therapy were typical of the dermatosis-arthritis syndrome, and probably were related to bacterial overgrowth.

Topics: Anastomosis, Roux-en-Y; Arthritis; Bacterial Infections; Bezoars; Candidiasis; Combined Modality Therapy; Dermatitis; Female; Gastrointestinal Contents; Humans; Intestinal Diseases; Jejunum; Lactobacillus; Middle Aged; Stomach; Streptococcal Infections; Syndrome; Tetracycline

Meningopolyradiculitis (Garin-Bujadoux syndrome, Bannwarth syndrome) is the second stage of Lyme disease, a tick-borne Borrelia infection. Almost 60% of these patients develop an acute peripheral facial paresis. The disease can be differentiated from Bell's palsy only by finding the specific Borrelia antibodies in serum and CSF. Other cranial nerve lesions can be found besides facial paresis. The follow-up of seven Borrelia-infected patients is described: one showed bilateral, the others unilateral, facial paresis. High dosage of penicillin or tetracycline for 10-14 days is the appropriate therapy. The prognosis of facial paresis in tick-borne Borrelia infection is considered to be good. All our patients showed complete recovery of motor nerve function.

Topics: Adolescent; Adult; Antibodies, Bacterial; Borrelia; Child; Facial Paralysis; Female; Follow-Up Studies; Humans; Lyme Disease; Male; Meningitis; Middle Aged; Polyradiculoneuropathy; Syndrome; Tetracycline

Sixty women with the diagnosis of urethral syndrome were consecutively assigned to one of three treatment modalities. The first group (20 patients) was treated with tetracycline, 2 g/d for ten days. The second group (20 patients) was treated with three serial urethral dilations at two- to three-week intervals, and the third group (20 patients) received placebo for ten days and served as a control group. A detailed clinical evaluation and uroflowmetry were performed before treatment and eight weeks afterwards. A subjective cure, which was defined as an absence of symptoms at the follow-up visits, was achieved in 20% of the placebo group, 50% of the tetracycline group and 75% of the urethral dilation group (P less than .01). An objective improvement in uroflowmetry occurred only in the group treated with serial urethral dilation.

Topics: Adult; Dilatation; Female; Follow-Up Studies; Humans; Middle Aged; Prospective Studies; Surveys and Questionnaires; Syndrome; Tetracycline; Urethral Diseases; Urination Disorders

Four cases of the Curtis-Fitz-Hugh syndrome diagnosed laparoscopically and with microbiological or serological evidence of chlamydial pelvic infection are reviewed. The case histories emphasize the part played by renal angle and left upper quadrant symptoms. In one patient the surface of the spleen was affected by the same classical inflammation normally seen on the surface of the liver. In 3 patients bilateral or left-sided renal angle pain and tenderness constituted the presenting features, or a major manifestation, and in all patients renal tract investigations were entirely normal. The patient with laparoscopic perisplenitis also had perihepatitis and pelvic inflammation, the latter being florid in all cases. Perisplenitis and perinephritis are proposed as possible additional manifestations of this syndrome.

Topics: Adolescent; Adult; Chlamydia Infections; Chlamydia trachomatis; Female; Hepatitis; Humans; Pelvic Inflammatory Disease; Perinephritis; Peritonitis; Splenic Diseases; Syndrome; Tetracycline

A case of Fitz-Hugh Curtis syndrome caused by chlamydia is described in which the perihepatic and abdominal swelling also extended to the right perirenal tissue. The case was diagnosed on the basis of the clinical picture, the behaviour of anti-chlamydia serum antibodies, abdominal echography and laparoscopy. The infection was quickly cured by the administration of tetracycline.

Topics: Adult; Chlamydia Infections; Condylomata Acuminata; Female; Hepatitis; Hepatitis, Chronic; Heroin Dependence; Humans; Salpingitis; Syndrome; Syphilis; Tetracycline; Vaginal Neoplasms

Fifteen patients with toxic epidermal necrolysis (TEN) were studied. In all of them the TEN was related to drug ingestion and believed to be drug-induced. The drugs implicated include pyrazolone derivatives, allopurinol, barbiturates, tetracycline, phenytoin, and penicillamine. Possible etiologic co-factors are infections, cancer, and the systemic lupus erythematosus diathesis. The extent of skin loss varied from 25% to almost 100% involvement of the total body surface. Seven of the fifteen patients had more than 75% epidermal loss. Three deaths were recorded (20%). From observations on these fifteen patients it was found that a single drug can cause two "reaction" patterns, namely, Stevens-Johnson syndrome (or erythema multiforme) and TEN, at the same time or at different times in one and the same patient. It is stressed that from the prognostic and therapeutic viewpoints patients with TEN may be equated to patients with extensive partial-thickness burns and should be treated in a burn unit.

Topics: Adult; Aged; Anti-Inflammatory Agents; Antipyrine; Barbiturates; Burns; Child; Diagnosis, Differential; Drug Eruptions; Female; Humans; Male; Middle Aged; Necrosis; Penicillamine; Phenytoin; Syndrome; Tetracycline

Topics: Animals; Diet; Oryza; Penicillin V; Periodontal Diseases; Periodontium; Rats; Syndrome; Tetracycline

Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Drug Hypersensitivity; Erythromycin; Humans; Hydrocortisone; Injections, Intravenous; Male; Middle Aged; Penicillin G; Relapsing Fever; Syndrome; Tetracycline

Topics: Anemia, Hypochromic; Breast Feeding; Deglutition Disorders; Female; Ferritins; Gastrointestinal Hemorrhage; Hemorrhage; Hemosiderin; Humans; Intestinal Absorption; Iron; Male; Pregnancy; Sex Factors; Syndrome; Tetracycline

Topics: Chronic Disease; Cyanosis; Humans; Inflammation; Lung Diseases; Male; Middle Aged; Osteoarthropathy, Secondary Hypertrophic; Penicillins; Pneumoconiosis; Smoking; Syndrome; Tetracycline; Tomography, X-Ray; Vasopressins

Topics: Ampicillin; Anti-Bacterial Agents; Bacterial Infections; Bronchitis; Carbenicillin; Cephalosporins; Chloramphenicol; Chronic Disease; Drug Synergism; Escherichia coli Infections; Gentamicins; Humans; Penicillin G; Pseudomonas Infections; Staphylococcal Infections; Sulfonamides; Syndrome; Tetracycline; Trimethoprim

Topics: Adult; Alcoholism; Ampicillin; Cephalothin; Chloramphenicol; Escherichia coli Infections; Fatty Liver; Female; Hepatitis; Humans; Klebsiella Infections; Liver Cirrhosis; Male; Methicillin; Middle Aged; Penicillins; Peritonitis; Pneumococcal Infections; Streptomycin; Syndrome; Tetracycline

This report documents the occurrence of Brill-Zinsser disease in a 48-year-old woman who experienced typhus fever in a German concentration camp. This is the first report of a case of recrudescent typhus in a European immigrating to Canada following World War II. The last reported case of Brill-Zinsser disease in Canada occurred in 1953.

Topics: Canada; Diagnosis, Differential; Female; Humans; Jews; Middle Aged; Recurrence; Salmonella Infections; Syndrome; Tetracycline; Typhus, Epidemic Louse-Borne

Topics: Achlorhydria; Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Antibodies; Erythrocyte Count; Folic Acid; Histamine; Humans; Intrinsic Factor; Malabsorption Syndromes; Middle Aged; Pentagastrin; Reticulocytes; Schilling Test; South Africa; Stimulation, Chemical; Syndrome; Tetracycline; Vitamin B 12

Topics: Acne Vulgaris; Acute Disease; Adolescent; Ampicillin; Anemia; Anti-Bacterial Agents; Cephalosporins; Erythromycin; Female; Fever; Follow-Up Studies; Humans; Joint Diseases; Leukemoid Reaction; Male; Nephritis; Prednisolone; Skin Diseases; Syndrome; Tetracycline; Triamcinolone

Topics: Anti-Bacterial Agents; Arthritis, Infectious; Cervix Uteri; Dermatitis; Female; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillin G; Penicillin Resistance; Skin Diseases, Infectious; Streptomycin; Syndrome; Tetracycline; Urethra; Virulence

Topics: Adolescent; Adult; Age Factors; Aged; Anemia, Macrocytic; Anemia, Pernicious; Autoantibodies; Black or African American; Black People; Diagnosis, Differential; Ethnicity; Folic Acid; Gastric Juice; Humans; Intrinsic Factor; Malabsorption Syndromes; Middle Aged; South Africa; Syndrome; Tetracycline; Vitamin B 12

Topics: Atrophy; Child; Cystic Fibrosis; Dwarfism; Humans; Male; Photosensitivity Disorders; Syndrome; Tetracycline

Topics: Adrenal Cortex Hormones; Age Factors; Ear, External; Facial Nerve; Facial Paralysis; Hearing Disorders; Herpes Zoster; Humans; Mouth Mucosa; Syndrome; Tetracycline

Topics: Adrenocorticotropic Hormone; Chloral Hydrate; Chlorpromazine; Cortisone; Electromyography; Female; Fibromyalgia; Gait; Humans; Male; Meprobamate; Muscular Diseases; Neostigmine; Reflex, Abnormal; Syndrome; Tachycardia, Paroxysmal; Tetanus Antitoxin; Tetracycline; Vitamin B Complex

Topics: Anti-Bacterial Agents; Chickenpox; Convalescence; Drug Therapy; Eczema; Herpes Simplex; Humans; Hydrocortisone; Infant; Kaposi Varicelliform Eruption; Pathology; Syndrome; Tetracycline

Topics: Anti-Bacterial Agents; Blood Chemical Analysis; Hypokalemia; Kidney Diseases; Pathology; Potassium; Potassium Deficiency; Syndrome; Tetracycline; Toxicology

Topics: Acidosis; Amino Acids; Glycosuria; Proteinuria; Syndrome; Tetracycline

Topics: Aniline Compounds; Anti-Bacterial Agents; Dermatitis, Contact; Diagnosis, Differential; Drug Eruptions; Drug Hypersensitivity; Food Additives; Food Contamination; Humans; Hydralazine; Lupus Erythematosus, Systemic; Pesticides; Pigmentation Disorders; Syndrome; Tetracycline; Toxicology

Topics: Anti-Bacterial Agents; Chloramphenicol; Female; Humans; Postpartum Period; Pregnancy; Puerperal Disorders; Puerperal Infection; Syndrome; Tetracycline

Topics: Anti-Bacterial Agents; Cervical Rib; Humans; Nervous System; Nervous System Diseases; Ribs; Syndrome; Tetracycline