tetracycline and Skin-Ulcer

A randomized, single-blind, controlled study comparing the efficacy of an ointment containing two antibiotics, one containing one antibiotic plus hydrocortisone, and no treatment in reducing secondary infections in patients with patent Guinea worm was undertaken in the northern region of Ghana. Seventy-seven patients were included. Time to complete healing was significantly shorter in the treatment groups compared with the controls (P = 0.044 and P = 0.003, respectively). Secondary infections occurred more often in the controls (P = 0.00014). Ointments containing antibiotics are recommended for application at the early stage of patent Guinea worm infection.

Topics: Administration, Topical; Adolescent; Adult; Aged; Bacterial Infections; Child; Child, Preschool; Dracunculiasis; Drug Combinations; Female; Humans; Hydrocortisone; Male; Middle Aged; Ointments; Polymyxin B; Single-Blind Method; Skin Ulcer; Tetracycline

Topics: Albuminuria; Anemia; Arrhythmias, Cardiac; Aspartate Aminotransferases; Chloramphenicol; Conjunctivitis; Evaluation Studies as Topic; Fever; Hepatomegaly; Humans; Hypotension, Orthostatic; Leukopenia; Lymphatic Diseases; Male; Military Medicine; Recurrence; Scrub Typhus; Skin Ulcer; Splenomegaly; Tetracycline

Oleoma or paraffinoma is defined as a foreign body granuloma that results from the injection of oily substances into the skin or subcutaneous tissue. We present a young patient with ulcerated lesions secondary to infiltration of oily material. He had undergone the injections with the aim of increasing muscle mass and definition. The treatment of these cases is quite complex, often with unsatisfactory results. The use of long-term oral tetracycline proved to be helpful.

Topics: Adult; Female; Granuloma, Foreign-Body; Humans; Injections, Subcutaneous; Oils; Skin Ulcer; Tetracycline

In this retrospective investigation, we documented the bacterial colonization of 79 patients with chronic wounds, who had been treated between January 2002 and May 2003 in an outpatient wound healing clinic of a university dermatology program. We isolated 106 facultative pathogenic bacterial strains of which 56 were Staphylococcus aureus, 19 Pseudomonas aeruginosa, 11 Escherichia coli, 4 Proteus mirabilis, 4 Enterobacter cloacae, 2 Serratia marcescens, 2 Streptococcus group G und 8 further species. 68 of these bacterial strains were gram-positive and 46 gram-negative. Moreover we identified one patient with Candida parapsilosis. Therefore, 70.8% of all patients showed Staphylococcus aureus in their chronic wounds. Determination of the specific resistances showed 17 patients to be colonized with oxacillin- resistant Staphylococcus aureus (ORSA) strain; this corresponds to 21.5% of all patients. Consequently, 30.4% of all Staphylococcus aureus isolates were ORSA strains. All of the ORSA isolates were sensitive to vancomycin. Sensitivity to tetracycline was documented in 15, to amikacin in 13, to clindamycin in 7, to gentamicin and erythromycin in 6 of the ORSA-positive patients. In the case of trimethoprim/sulfamethoxazole, 10 were sensitive and 3 were intermediate in sensitivity. Beside the obligate resistance to oxacillin, penicillin G, ampicillin, cefuroxime and imipenem, none of the ORSA was sensitive to ofloxacin. The results of our investigations demonstrate the actual spectrum of bacterial colonization in chronic wounds of patients in an university dermatologic wound clinic and underline the growing problem of ORSA.

Topics: Aged; Aged, 80 and over; Bacteriological Techniques; Chronic Disease; Clindamycin; Drug Resistance, Multiple, Bacterial; Erythromycin; Female; Foot Ulcer; Gentamicins; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Oxacillin; Penicillin Resistance; Pressure Ulcer; Radiodermatitis; Skin Diseases, Bacterial; Skin Ulcer; Staphylococcal Skin Infections; Tetracycline; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin; Vancomycin Resistance; Varicose Ulcer; Wound Infection

Twenty nine patients with genital fixed drug eruptions were studied during one year. In 15 the genitalia were exclusively affected, whereas the other 14 had cutaneous lesions in addition. It was striking that those whose lesions were exclusively genital reported for consultation much earlier. Drug history was the mainstay of diagnosis. Provocation tests with graded doses of the suspected drug(s) were undertaken in all cases. Tetracycline was the commonest causative drug, followed by oxyphenbutazone and acetylsalicylic acid.

Topics: Adolescent; Adult; Child; Drug Hypersensitivity; Female; Humans; Male; Middle Aged; Penile Diseases; Skin Tests; Skin Ulcer; Tetracycline; Vaginal Diseases; Vulvar Diseases

A case of Hemophilus ducreyi infection clinically resembling granuloma inguinale is reported. Culture of the causative organism permitted a definitive diagnosis to be made. Combined treatment with tetracycline and sulphamethizole/trimethoprim rapidly cleared the infection.

Topics: Adult; Chancroid; Diagnosis, Differential; Drug Combinations; Drug Therapy, Combination; Granuloma Inguinale; Humans; Male; Skin Ulcer; Tetracycline; Trimethoprim, Sulfamethoxazole Drug Combination

Over the past 10 years, it has been well established that Crohn's disease may involve any segment of the gastrointestinal tract from the mouth to the anus and may also cause destructive extraintestinal lesions. Extensive cutaneous ulceration has recently been recognized as one of the rare extraintestinal complications. A case of chronic vulvar ulceration due to Crohn's disease is reported. The clinical manifestations and management of such a lesion are discussed.

Topics: Abscess; Adult; Aminosalicylic Acids; Biopsy; Buttocks; Colectomy; Complement Fixation Tests; Crohn Disease; Female; Humans; Ileostomy; Isoniazid; Pregnancy; Skin Ulcer; Steroids; Tetracycline; Vulva; Vulvar Diseases

The improved control over most infectious disease does not extend to venereal infections, and these now provide the major medical problem encountered in wartime. This factor should be recognized when staff and facilities are being provided for wartime medical services. Unique problems of management of both physical and psychological illness may result from promiscuity in a foreign land during war, and specialist venereologists are as necessary as surgeons and physicians.

Topics: Australia; Chancroid; Drug Resistance, Microbial; Humans; Male; Military Medicine; Penile Diseases; Seasons; Sexually Transmitted Diseases; Skin Ulcer; Streptomycin; Sulfisoxazole; Tetracycline; Urethritis; Vietnam; Warfare; Warts

Topics: Administration, Topical; Adult; Diabetes Complications; Diabetes Mellitus; Diabetic Coma; Foot Dermatoses; Gangrene; Humans; Hyperglycemia; Insulin; Ischemia; Skin Ulcer; Tetracycline; Tetracyclines

Topics: Animals; Antibodies, Bacterial; Diagnosis, Differential; Fluorescent Antibody Technique; Humans; Infectious Mononucleosis; Male; Mice; Neurologic Manifestations; Orientia tsutsugamushi; Proteus; Scrub Typhus; Skin Manifestations; Skin Ulcer; Tetracycline; Time Factors; Vietnam

Topics: Acne Vulgaris; Adolescent; Adult; Animals; Child, Preschool; Eczema; Female; Furunculosis; Humans; Male; Mice; Microbial Sensitivity Tests; Skin Diseases, Infectious; Skin Ulcer; Staphylococcal Infections; Staphylococcus; Suppuration; Tetracycline

Topics: Adolescent; Adult; Aged; Animals; Child; Disease Outbreaks; Disease Vectors; Female; Fluorescent Antibody Technique; Francisella tularensis; Hemagglutination Tests; Humans; Lymphadenitis; Male; Middle Aged; Penicillins; Rodentia; Skin Ulcer; Streptomycin; Tetracycline; Tularemia; Vermont; Water Pollution; Zoonoses