tetracycline and Skin-Diseases

New drugs are available for managing several common skin disorders. For psoriasis, topical corticosteroids remain the first-line therapy, but topical vitamin D3 analogs, such as calcipotriene, now have a role. They are as effective as medium-potency topical steroids but without steroid side effects, though they can induce hypercalcemia if the dose exceeds 100 g/week. For more severe cases, methotrexate has been widely used, but other drugs now also are prescribed. They include calcineurin inhibitors, such as cyclosporine, and more recently, biologic agents, such as tumor necrosis factor inhibitors. For children and pregnant women, in whom the previously discussed drugs are not appropriate, narrowband UV-B light often is the first-line treatment. For eczema, patients requiring steroid-sparing topical drugs can be treated with calcineurin inhibitors (ie, pimecrolimus or tacrolimus); between the 2, tacrolimus is the first choice for adults and children older than 2 years. When systemic management is needed, oral calcineurin inhibitors (eg, cyclosporine) are appropriate, though oral steroids often are needed for severe cases. The need for systemic management can sometimes be delayed with use of diluted bleach baths. For acne vulgaris, standard treatments with topical benzoyl peroxide and topical or systemic antibiotics are used widely, as are oral contraceptives, but oral isotretinoin is the most effective treatment.

Topics: Acne Vulgaris; Administration, Oral; Administration, Topical; Adrenal Cortex Hormones; Calcineurin Inhibitors; Child; Dermatologic Agents; Eczema; Female; Histamine Antagonists; Humans; Immunologic Factors; Infant; Middle Aged; Psoriasis; Retinoids; Skin Diseases; Tetracycline

Topics: Arthritis, Infectious; Ceftriaxone; Drug Administration Schedule; Erythema; Humans; Lyme Disease; Nervous System Diseases; Penicillins; Skin Diseases; Tetracycline

Whipple's disease is a systemic bacterial infection that once was uniformly fatal and now is treatable with several different antibiotics in most cases. The exact nature of the Whipple's bacillus is unknown, since the organism cannot consistently be cultured. There is also controversy concerning the role of immunologic dysfunction in patients with Whipple's disease. In addition to the small intestine, Whipple's disease can involve the remainder of the gastrointestinal tract, as well as the lymph nodes, joints, nervous system, heart, eyes, hematopoietic system, lungs, liver, and other organs. The clinical manifestations, diagnosis, and treatment of this rare but fascinating disease will be reviewed in this article.

Topics: Bacterial Infections; Diagnosis, Differential; Drug Combinations; Eye Diseases; Heart Diseases; Hematologic Diseases; Humans; Joint Diseases; Lung Diseases; Lymphatic Diseases; Muscular Diseases; Nervous System Diseases; Penicillins; Skin Diseases; Streptomycin; Sulfamethoxazole; Tetracycline; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Whipple Disease

Topics: Adrenal Cortex Hormones; Azathioprine; Cryosurgery; Cyclophosphamide; Electrosurgery; Erythromycin; Hexachlorocyclohexane; Humans; Hydroxyurea; Iatrogenic Disease; Methotrexate; Podophyllin; Radiotherapy; Skin Diseases; Tetracycline; Ultraviolet Therapy

Systemic complications of drugs commonly prescribed by dermatologists fortunately are uncommon. Nevertheless, it is extremely important that the dermatologist be aware of medical contraindications to the use of these agents, as well as their potential systemic side effects. These considerations for methotrexate, sulfones, tetracyclines, and corticosteroids are reviewed.

Topics: Blood; Cataract; Dapsone; Dermatitis; Glaucoma; Glucocorticoids; Growth; Humans; Kidney; Liver; Methotrexate; Peptic Ulcer; Skin Diseases; Tetracycline

Topics: Ampicillin; Anti-Bacterial Agents; Deodorants; Erythromycin; Humans; Penicillin G; Penicillin G Benzathine; Penicillin G Procaine; Penicillin Resistance; Penicillins; Skin Diseases; Soaps; Streptococcal Infections; Tetracycline

Topics: Acne Vulgaris; Alopecia Areata; Dermatitis, Contact; Humans; Lupus Erythematosus, Systemic; Lymphatic Diseases; Methotrexate; Ointments; Photosensitivity Disorders; Porphyrias; Psoriasis; Rosacea; Skin Diseases; Steroids; Sunscreening Agents; Tetracycline; Tinea; Trichophyton; Urea; Vitiligo

Topics: Acne Vulgaris; Adult; Aged; Child, Preschool; Female; Gonorrhea; Hirsutism; Humans; Ichthyosis; Infant; Male; Melphalan; Middle Aged; Psoriasis; Sarcoidosis; Skin Diseases; Skin Neoplasms; Syphilis; Tetracycline; United States

Topics: Acne Vulgaris; Child; Female; Humans; Pregnancy; Pregnancy Complications; Skin; Skin Diseases; Stomatitis, Aphthous; Tetracycline; Tooth Discoloration

Topics: Bone Development; Bone Diseases; Child, Preschool; Dentition; Enzyme Repression; Female; Humans; Infant; Infant, Newborn; Maternal-Fetal Exchange; Nails; Pregnancy; Pregnancy Complications, Infectious; Protein Biosynthesis; Skin Diseases; Tetracycline; Tooth Discoloration

Afatinib has shown long progression free survival and improvement in quality of life in advanced Non-Small Cell Lung Cancer (NSCLC) patients. Although afatinib causes acneiform rash, it can be manageable. Tetracyclines are usually used to treat it; nonetheless, there is no trial that evaluates their prophylactic efficacy on afatinib induced-skin toxicities (AIST).. This open-label, randomized, controlled trial assessed the preventive effect of tetracycline for reducing afatinib-skin toxicities in NSCLC patients receiving afatinib 40 mg/day. Patients were randomly assigned to receive pre-emptive treatment with tetracycline 250 mg every 12h for 4 weeks or not. Reactive treatment in both groups included general dermatological recommendations such as use of skin moisturizers, sunscreen and topical steroids, according to toxicity severity. All patients were blindly monitored for skin toxicities by an expert dermatologist at the start of treatment with afatinib (day 0), weeks 2 and 4 of treatment. The protocol is registered on clinicaltrials.gov (NCT01880515).. We included 90 patients, no differences were found in clinical and dermatological baseline characteristics. Rash incidence of any grade, and grade ≥2 was less frequent in the pre-emptive arm vs. the control arm (44.5 vs. 75.6%, RR 0.4 [95% CI 0.17-0.99], p=0.046 and 15.6 vs. 35.6%, RR 0.35 [95% CI, 0.12-0.91], p=0.030, respectively). No difference was found in paronychia, xerosis, mucositis, folliculitis, and skin fissure. No adverse event was associated with tetracycline. Neither rash nor pre-emptive tetracycline impacted on response rate, progression-free or overall survivals.. Pre-emptive tetracycline was well tolerated and reduced the rash incidence and severity associated with afatinib in more than 60%.

Topics: Adult; Afatinib; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Pre-Exposure Prophylaxis; Quinazolines; Risk Factors; Skin Diseases; Tetracycline

Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Female; Foot Dermatoses; Hand Dermatoses; Humans; Male; Middle Aged; Placebos; Radiography; Skin Diseases; Staphylococcus; Tetracycline

In a comparative investigation incised skin abscesses were treated by either introducing sterile fusidic acid gel into the cavity on one occasion only or applying daily superficial dressings impregnated with sodium fusidate ointment. In comparison with the dressing group, the intracavity use of fusidic acid gel reduced the mean healing time of incised abscesses by approximately one-half. When abscesses were analysed according to site and size, the reduction in mean healing time was equally striking. No hypersentisivity or irritation to fusidic acid or its sodium salt applied by either method was observed.The procedure of introducing fusidic acid gel into an incised abscess cavity is a promising alternative to superficial antibiotic dressings or wicks in the treatment of incised abscesses.

Topics: Abscess; Bandages; Drug Hypersensitivity; Fusidic Acid; Gels; Humans; Ointments; Penicillins; Skin Diseases; Tetracycline; Time Factors; Wound Healing

(1) Photosensitivity reactions are cutaneous disorders due to exposure to ultraviolet (UV) radiation of natural or artificial origin. They occur or are more prevalent on unprotected skin. The main clinical manifestations are burns, eczema-like rash, urticaria, pigmentation, or onycholysis; (2) Many drugs increase cutaneous sensitivity to UV, sometimes for therapeutic purposes, but it is generally an unwanted effect.

Topics: Aminolevulinic Acid; Amiodarone; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Agents; Dermatitis, Photoallergic; Dermatitis, Phototoxic; Dihematoporphyrin Ether; Diuretics; Doxycycline; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Eczema; Furocoumarins; Hematoporphyrin Photoradiation; Humans; Methotrexate; Onycholysis; Photochemotherapy; Photosensitivity Disorders; Photosensitizing Agents; Porphyrins; Psychotropic Drugs; Quinolines; Skin; Skin Aging; Skin Diseases; Skin Neoplasms; Skin Pigmentation; Sulfonamides; Sunscreening Agents; Tetracycline; Ultraviolet Rays; Urticaria; Verteporfin

Medication induced esophagitis (MIE) has been reported in dermatology patients taking tetracycline antibiotics. The symptoms of esophagitis, preventable with proper instruction, can create morbidity and lead to increased costs for patients. Our study sought to quantify the incidence of MIE in patients taking tetracycline antibiotics and to investigate how these patients develop MIE. A cross-sectional questionnaire survey was given at outpatient dermatology clinics. Ninety-three surveys from patients who had taken tetracycline antibiotics and 48 surveys from a control group were analyzed. Incidence of esophagitis symptoms (difficulty or pain with swallowing) was measured in both survey and control groups. We found that esophagitis is significantly more common in patients taking tetracycline and its derivatives as compared with a control group (p<.03). Patients should be counseled to take tetracycline antibiotics in an upright position with a large amount of fluid and to report esophagitis symptoms to the prescribing physician.

Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Cross-Sectional Studies; Esophagitis; Female; Hospitals, University; Humans; Male; Middle Aged; Ohio; Severity of Illness Index; Skin Diseases; Surveys and Questionnaires; Tetracycline

A 60-year-old man with common variable immunodeficiency presented with a 7-year history of violaceous plaques and papules on the thighs, arms and trunk. In the preceding 2 years he had developed new lesions on both hands. He had been previously diagnosed with sarcoidosis on the basis of skin and visceral histology, but subsequent opinion was that these were sarcoid-like granulomas rather than being representative of true sarcoidosis. Biopsy of the hand lesions showed necrotizing granulomas, and a single acid-fast bacillus (AFB) was identified on Wade-Fite stain. Subsequent repeat tissue biopsies for histology, culture and polymerase chain reaction testing failed to confirm the presence of mycobacterial organisms and it was felt that the organism was a contaminant introduced during tissue processing. The hand lesions responded well to intralesional injections of triamcinolone acetonide 10 mg/mL and oral tetracycline 500 mg b.d. was later introduced with a good clinical response. The diagnostic dilemma of finding granulomatous inflammation in a patient with common variable immunodeficiency, and the significance of a single AFB on histology are discussed. The treatment of sarcoid-like granulomas with tetracycline therapy is also commented on.

Topics: Anti-Bacterial Agents; Common Variable Immunodeficiency; Diagnosis, Differential; Glucocorticoids; Granuloma; Humans; Male; Middle Aged; Sarcoidosis; Skin; Skin Diseases; Tetracycline; Tuberculosis, Cutaneous

A buffalo disease, called "Degnala", causing lameness, edema, gangrenous ulceration of hooves or tail, emaciation, recumbency and eventual death, occurs in Eastern Nepal. Clinical examinations manifested lice eggs on hairs, bradycardia, hypothermia, dehydration, exanthema and icterus. Hematologically, increase of band neutrophil, giant platelet, hypoalbuminemia and hyperglobulinemia were characteristics. Microscopically, dark blue tiny particles were seen on red blood cell (RBC) after Giemsa staining. Administration of tetracycline at an early stage of the disease was effective.

Topics: Animal Diseases; Animals; Anti-Bacterial Agents; Buffaloes; Disease Outbreaks; Extremities; Female; Foot Diseases; Hoof and Claw; Lice Infestations; Male; Nepal; Skin Diseases; Tail; Tetracycline

Topics: Anti-Bacterial Agents; Drug Eruptions; Female; Humans; Knee; Middle Aged; Pain; Skin Diseases; Tetracycline

All of the 88 episodes of beta-haemolytic streptococcal bacteremia (2.9% of all bacteremias) in adult patients during the years 1987-94 in a university hospital were reviewed. 38 bacteremias (43%) were caused by group A, 24 (27%) by group B, 3 (4%) by group C, and 23 (26%) by group G beta-haemolytic streptococcal. There was a statistically significant increase in group A and decrease in group C and G bacteremias (p < 0.02) compared to an earlier 8-year period in the same hospital, although the total number of streptococcal bacteremias remained the same. The most common T types of group A streptococcal strains were T11 (26%), T28 (14%), T6 and T1 (11% each), and T12 (8%). Cardiovascular disease, skin lesions, malignancy, and alcohol abuse were the most common underlying conditions. The most usual types of infection were skin (47%) and respiratory tract infections (23%). The overall mortality was 16%. It was highest in group A (24%) and lowest in group C (0%), 38% of patients with pneumonia died. All streptococcal strains were sensitive to penicillin, vancomycin, and cephalosporins. 11% of group A and 12% of all the strains had decreased sensitivity to erythromycin, 14 and 38% to tetracycline, and 0 and 2% to clindamycin, respectively.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; Bacterial Typing Techniques; Cardiovascular Diseases; Clindamycin; Drug Resistance, Microbial; Erythromycin; Female; Finland; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Neoplasms; Retrospective Studies; Skin Diseases; Streptococcal Infections; Streptococcus; Streptococcus agalactiae; Streptococcus pyogenes; Tetracycline

Topics: Contraceptives, Oral; Dermatologic Agents; Drug Therapy, Combination; Female; Humans; Retinoids; Skin Diseases; Tetracycline

A combination of niacinamide and tetracycline was used to treat 31 dogs with various autoimmune skin diseases (discoid lupus erythematosus, pemphigus foliaceus, pemphigus erythematosus, and bullous pemphigoid). Of the 20 dogs with discoid lupus erythematosus, 70% had excellent or good response to treatment. Serious side effects were not noticed in any dog.

Topics: Animals; Autoimmune Diseases; Dog Diseases; Dogs; Drug Combinations; Female; Lupus Erythematosus, Discoid; Niacinamide; Pemphigoid, Bullous; Pemphigus; Skin Diseases; Tetracycline

Topics: Acne Vulgaris; Administration, Oral; Adolescent; Dermatologic Agents; Dicarboxylic Acids; Drug Evaluation; Facial Dermatoses; Humans; Ointments; Skin Diseases; Tetracycline

Topics: Ascorbic Acid; Chemotactic Factors; Chemotaxis, Leukocyte; Dipeptides; Humans; Neutrophils; Prednisolone; Skin Diseases; Tetracycline

Topics: Acquired Immunodeficiency Syndrome; Hemophilia A; Humans; Male; Middle Aged; Skin Diseases; Telangiectasis; Tetracycline

Inquiries regarding tick exposure can be important in dermatologic diagnosis and treatment since ticks can be vectors of a diversity of infectious diseases. The classic teaching is that ticks are best removed with nail polish, solvents, petrolatum, mineral oil, or a hot match. However, a recent evaluation of tick removal revealed that mechanical removal with forceps preceded and followed by disinfection is the most effective method. In most cases, should the characteristic dermatologic lesion or systemic symptoms appear, appropriate treatment should be initiated for presumptive diseases.

Topics: Animals; Arachnid Vectors; Bites and Stings; Humans; Rocky Mountain Spotted Fever; Skin Diseases; Tetracycline; Ticks

Topics: Alcoholism; Bloodletting; Female; Furosemide; Humans; Hydroxychloroquine; Kidney Failure, Chronic; Male; Nalidixic Acid; Porphyrias; Skin Diseases; Terminology as Topic; Tetracycline

Lyme disease is a newly recognized disease with diverse but characteristic inflammatory manifestations that involve the skin, joints, heart, and CNS. The illness develops following the bite of the Ixodes tick and is caused by a Treponema-like spirochete. This article reviews the causal, epidemiologic, clinical, and laboratory features of this illness. Since a large number of patients described with this treatable disease have been children and the disease may be confused with other more serious illnesses, Lyme disease is worthy of the pediatrician's awareness.

Topics: Arthritis, Infectious; Bites and Stings; Child; Diagnosis, Differential; Erythromycin; Heart Diseases; Humans; Penicillins; Skin Diseases; Tetracycline; Ticks

Delayed passage of irritant drugs like tetracycline hydrochloride can cause esophageal ulceration, especially when the medication is taken with only a sip of water before sleeping or by a patient with stricture or motor abnormality of the esophagus. Certain precautions should be taken when prescribing irritant drugs. Patients should be advised to take sufficient quantities of water with the medication and to avoid taking the capsules at bedtime. These drugs should not be given to patients with esophageal obstruction or motility disorders.

Topics: Acne Vulgaris; Adolescent; Adult; Esophageal Diseases; Female; Humans; Male; Skin Diseases; Tetracycline; Ulcer

Topics: Actinobacillus; Actinobacillus Infections; Fistula; Humans; Intestinal Fistula; Lumbosacral Region; Male; Middle Aged; Retroperitoneal Space; Skin Diseases; Tetracycline

Blue nodules developed in the skin of a patient with acne concomitant with the start of tetracycline therapy. When removed, these nodules were brown and histologic examination revealed a lamellate structure compatible with bone. Under ultraviolet light, these osteomas fluoresced yellow, indicating the presence of tetracycline. This suggests that tetracycline, combined with new bone formation, causes pigmentation of osteoma cutis.

Topics: Acne Vulgaris; Adult; Calcinosis; Female; Humans; Osteogenesis; Skin Diseases; Skin Pigmentation; Tetracycline

Topics: Animals; Antibodies; Child; Granuloma; Humans; Male; Ointments; Skin Diseases; Tetracycline

Topics: Acne Vulgaris; Drug Evaluation; Factor Analysis, Statistical; Humans; Sampling Studies; Skin Diseases; Tetracycline

Topics: Adolescent; Diagnosis, Differential; Female; Humans; Nails; Photosensitivity Disorders; Skin Diseases; Tetracycline

The administration of anti-androgens brings favourable results especially in such skin diseases showing unsatisfactory therapeutic results, i.e. all severe forms of acne, seborrhoea, androgenic alopecia and hirsutism. Exact knowledge of the oestrogen and gestagen effect is essential. Also of fundamental importance is the observation and consideration of side effects besides the contraceptive efficacy and therapeutic results in dermatology.

Topics: Acne Vulgaris; Alopecia; Androgen Antagonists; Contraceptives, Oral; Contraceptives, Oral, Hormonal; Dermatitis, Seborrheic; Female; Hirsutism; Humans; Hypertrichosis; Skin Diseases; Tetracycline; Tretinoin

Topics: Adult; Female; Humans; Nails; Photosensitivity Disorders; Skin Diseases; Tetracycline

Topics: Adolescent; Drug Hypersensitivity; Escherichia coli Infections; Female; Fingers; Hemorrhage; Humans; Nails; Photosensitivity Disorders; Pigmentation Disorders; Skin Diseases; Tetracycline

Topics: Adipose Tissue; Humans; Inflammation; Skin Diseases; Tetracycline

Topics: Administration, Topical; Anti-Inflammatory Agents; Dermatitis; Dermatitis, Seborrheic; Dermatologic Agents; Drug Prescriptions; Eczema; Female; Humans; Hydrocortisone; Male; Neomycin; Ointment Bases; Psoriasis; Salicylates; Skin Diseases; Sulfur; Tetracycline

Phototoxic and photoallergic reactions of the skin are certainly not very common, but, on the other hand, the complete list of medicinal substances which are accused of causing them is extremely extensive. For this reason, dispensing with many details, an attempt is made to present the basis of such reactions. After irradiation with longwave ultra-violet light, which alone would not have produced inflammation, a reaction occurred through the agency of many drugs which can proceed according to a toxic or allergic mechanism.

Topics: Anilides; Diagnosis, Differential; Drug Hypersensitivity; Humans; Light; Phenothiazines; Photosensitivity Disorders; Salicylates; Skin Diseases; Skin Tests; Sulfonamides; Tars; Tetracycline; Ultraviolet Rays

Topics: Acne Vulgaris; Adolescent; Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Bilirubin; Blood Urea Nitrogen; Child; Female; Follow-Up Studies; Humans; Kidney Function Tests; Liver Function Tests; Male; Middle Aged; Rosacea; Skin Diseases; Tetracycline; Time Factors

Topics: Agranulocytosis; Amphotericin B; Anemia, Aplastic; Anemia, Hemolytic; Anti-Bacterial Agents; Ataxia; Bacitracin; Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Chloramphenicol; Deafness; Gastrointestinal Diseases; Gentamicins; Humans; Kanamycin; Kidney Diseases; Leukopenia; Lung Diseases; Neomycin; Neuromuscular Diseases; Nitrofurantoin; Optic Neuritis; Peripheral Nervous System Diseases; Skin Diseases; Streptomycin; Sulfonamides; Tetracycline; Thrombocytopenia; Vertigo

Topics: Administration, Topical; Bronchial Neoplasms; Eye Manifestations; Fluorescent Antibody Technique; Humans; Immunoglobulin G; Microscopy, Fluorescence; Middle Aged; Quinolines; Skin Diseases; Tetracycline

Topics: Adult; Female; Humans; Nails; Photosensitivity Disorders; Skin Diseases; Sunburn; Tetracycline

Topics: Adult; Aged; Arm; Female; Fingers; Foot Dermatoses; Granuloma; Hand Dermatoses; Humans; Male; Middle Aged; Mycobacterium; Mycobacterium Infections; Skin Diseases; Tetracycline; Toes

Topics: Acne Vulgaris; Acute Disease; Adolescent; Ampicillin; Anemia; Anti-Bacterial Agents; Cephalosporins; Erythromycin; Female; Fever; Follow-Up Studies; Humans; Joint Diseases; Leukemoid Reaction; Male; Nephritis; Prednisolone; Skin Diseases; Syndrome; Tetracycline; Triamcinolone

Topics: Adolescent; Adult; Demeclocycline; Female; Humans; Male; Middle Aged; Nails; Photosensitivity Disorders; Skin Diseases; Tetracycline

Topics: Adolescent; Adrenal Cortex Hormones; Anti-Bacterial Agents; Antineoplastic Agents; Chloramphenicol; Contraceptives, Oral; Dermatitis, Contact; Dermatologic Agents; Drug Eruptions; Drug Interactions; Female; Hair; Humans; Male; Melanosis; Neomycin; Penicillins; Skin; Skin Diseases; Tetracycline

The prevalence of tetracycline-resistant beta-haemolytic streptococci in South-west Essex has been recorded over the past 10 years. It has fallen from a peak of 35% in 1965 to a level of 9.2% in 1972. Ear infections no longer provide the highest incidence of these organisms; vaginal, perineal, and skin infections now seem to be of greater relative importance but throat swabs still provide the greatest actual number of isolations. Erythromycin-resistant strains are still rare.

Topics: Drug Resistance, Microbial; Ear; Ear Diseases; England; Erythromycin; Female; Humans; Nose; Paranasal Sinuses; Perineum; Pharynx; Skin Diseases; Sputum; Streptococcal Infections; Streptococcus pyogenes; Tetracycline; Vaginal Diseases; Vulva; Wounds and Injuries

Topics: Adult; Chlamydia; Chlamydia Infections; Female; Humans; Penicillins; Skin Diseases; Streptomycin; Tetracycline

Topics: Adolescent; Adult; Bites and Stings; Blood Cell Count; Blood Coagulation Tests; Child; Child, Preschool; Chloramphenicol; Complement Fixation Tests; Female; Fever; Headache; Humans; Leukocytosis; Male; Mental Disorders; Rocky Mountain Spotted Fever; Seasons; Serologic Tests; Skin Diseases; South Carolina; Tetracycline; Ticks

Topics: Adrenal Cortex Hormones; Czechoslovakia; Diagnosis, Differential; Facial Dermatoses; Formularies as Topic; Medical History Taking; Skin Diseases; Tetracycline

An isolation policy in a hospital for skin diseases is reported. Patients carrying penicillin- and tetracycline-resistant organisms were to be isolated in single rooms, though barrier nursing was not practised. The policy failed because the single beds rapidly became blocked with long-stay patients and because even in a single-bed unit patients acquired staphylococci within 3-7 days of admission. Patients with skin diseases often do not feel ;ill' and resent isolation.

Topics: Attitude to Health; Cross Infection; Drug Resistance, Microbial; Female; Humans; Length of Stay; Male; Patient Isolators; Penicillin Resistance; Skin Diseases; Social Isolation; Staphylococcal Infections; Tetracycline

Topics: Ampicillin; Analgesics; Aspirin; Chlorpromazine; Drug-Related Side Effects and Adverse Reactions; Erythema Multiforme; Humans; Indomethacin; International Cooperation; Oxyphenbutazone; Oxytetracycline; Phenylbutazone; Photosensitivity Disorders; Skin Diseases; Stevens-Johnson Syndrome; Tetracycline; World Health Organization

Topics: Drug Resistance, Microbial; Hemolysin Proteins; Humans; Microbial Sensitivity Tests; Serotyping; Skin Diseases; Streptococcal Infections; Streptococcus; Tetracycline

Topics: Drug Hypersensitivity; Humans; Skin Diseases; Tetracycline

Topics: Aniline Compounds; Collagen Diseases; Cosmetics; Coumarins; Demecolcine; Dermatitis, Contact; Female; Furans; Humans; Hypersensitivity; Male; Phenothiazines; Photosensitivity Disorders; Salicylamides; Skin Diseases; Skin Tests; Soaps; Sulfanilamides; Sunlight; Tetracycline; Urticaria

Topics: Adolescent; Adult; Ampicillin; Anemia; Arthritis, Infectious; Arthritis, Reactive; Endocarditis, Bacterial; Female; Gonorrhea; Hepatitis; Humans; Male; Meningitis; Menstruation; Myocarditis; Neisseria gonorrhoeae; Penicillin G Procaine; Penicillin V; Pericarditis; Pregnancy; Pregnancy Complications, Infectious; Pyuria; Sepsis; Skin Diseases; Tetracycline

Studies on infections in a hospital for diseases of the skin are described. Patients were shown to acquire staphylococci in the groin and on the chest at about the same rate as in the nose. In contrast to surgical wards, many staphylococci were resistant to tetracycline but sensitive to penicillin. Nevertheless, much of the epidemic spread of staphylococci was with typical surgical-ward strains rather than with phage group II strains which might be thought typical of skin diseases.

Topics: Anti-Bacterial Agents; Carrier State; Cross Infection; Disease Outbreaks; Hospitals, Special; Humans; Nose; Penicillin Resistance; Penicillins; Skin; Skin Diseases; Staphylococcal Infections; Staphylococcus; Tetracycline; Thorax

Topics: Adolescent; Adult; Aerosols; Aged; Child; Child, Preschool; Drug Tolerance; Female; Humans; Hypersensitivity; Infant; Infant, Newborn; Male; Middle Aged; Skin Diseases; Tetracycline; Time Factors; Triamcinolone Acetonide

Topics: 17-Ketosteroids; Acne Vulgaris; Adrenal Cortex Hormones; Anti-Bacterial Agents; Betamethasone; Dermatitis; Fludrocortisone; Humans; Hydrocortisone; Intestinal Diseases; Intestine, Small; Ointments; Prednisolone; Psoriasis; Skin Diseases; Tetracycline

Topics: Humans; Skin Diseases; Tetracycline

Topics: Administration, Oral; Drug Hypersensitivity; Erythema; Humans; Pruritus; Skin Diseases; Tetracycline

Topics: Administration, Topical; Anti-Inflammatory Agents; Humans; Hydrocortisone; Neomycin; Prednisone; Skin Diseases; Sweat Glands; Tetracycline

Topics: Acne Vulgaris; Adult; Female; Humans; Skin Diseases; Tetracycline; Yeasts

Topics: Acne Vulgaris; Humans; Skin Diseases; Tetracycline

Topics: Acne Vulgaris; Adolescent; Adult; Aged; Animals; Dermatitis; Female; Furunculosis; Humans; Lymphadenitis; Male; Microbial Sensitivity Tests; Middle Aged; Photosensitivity Disorders; Rabbits; Skin; Skin Diseases; Staphylococcus; Tetracycline; Tinea

Topics: Acne Vulgaris; Adolescent; Adult; Aged; Blister; Blood Proteins; Chemical Phenomena; Chemistry; Female; Furunculosis; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Skin Diseases; Staphylococcus; Tetracycline

Topics: Abscess; Acne Vulgaris; Adolescent; Adult; Aged; Cellulitis; Demeclocycline; Female; Furunculosis; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Skin Diseases; Staphylococcus; Tetracycline

Topics: Adult; Amphotericin B; Bacteriological Techniques; Biopsy; Brain Abscess; Cerebrospinal Fluid Proteins; Hemiplegia; Humans; Isoniazid; Joint Diseases; Lung Diseases; Male; Meningitis; Nocardia Infections; Polymyxins; Prednisone; Pseudomonas Infections; Sarcoidosis; Skin Diseases; Sporotrichosis; Tetracycline

Topics: Abscess; Adolescent; Adult; Bile; Child; Escherichia coli; Female; Humans; Inflammation; Male; Microbial Sensitivity Tests; Middle Aged; Osteomyelitis; Skin Diseases; Staphylococcus; Surgical Wound Infection; Tetracycline; Wound Infection

Topics: Abscess; Adolescent; Adult; Animals; Bile; Escherichia coli; Female; Humans; Kidney; Klebsiella; Liver; Lung; Male; Microbial Sensitivity Tests; Middle Aged; Myocardium; Rats; Skin Diseases; Spleen; Staphylococcus; Tetracycline; Thyroid Diseases; Thyroid Gland; Wound Infection

Topics: Communicable Disease Control; Cross Infection; Disease Outbreaks; Drug Resistance, Microbial; Female; Hospitals, Special; Humans; London; Male; Neomycin; Pseudomonas aeruginosa; Skin Diseases; Streptococcal Infections; Streptococcus; Tetracycline

Topics: Adolescent; Adult; Child, Preschool; Escherichia coli; Female; Humans; Infections; Injections, Intramuscular; Male; Middle Aged; Penicillin Resistance; Penicillin V; Skin Diseases; Staphylococcus; Tetracycline; Wound Infection

Topics: Adolescent; Aged; Appendicitis; Chloramphenicol; Drug Synergism; Female; Humans; Infections; Male; Middle Aged; Peritonitis; Respiratory Tract Infections; Skin Diseases; Tetracycline

Topics: Cosmetics; Dermatitis, Contact; Humans; Phenothiazines; Photosensitivity Disorders; Salicylates; Skin Diseases; Soaps; Sulfonamides; Tetracycline; Urticaria

Topics: Aged; Anti-Infective Agents, Local; Diagnosis, Differential; Female; Hematoma; Humans; Male; Melanoma; Middle Aged; Nails; Pseudomonas aeruginosa; Pseudomonas Infections; Skin Diseases; Skin Neoplasms; Tetracycline; Warts

Topics: Acute Disease; Anti-Bacterial Agents; Bronchitis; Child; Child, Preschool; Chloramphenicol; Chronic Disease; Communicable Diseases; Diarrhea, Infantile; Enteritis; Humans; Hypersensitivity; Meningitis; Pneumonia; Pyelonephritis; Sepsis; Skin Diseases; Staphylococcal Infections; Tetracycline; Tooth Diseases; Tooth, Deciduous; Vomiting; Whooping Cough

Topics: Actinomycosis; Animals; Chloramphenicol; Dihydrostreptomycin Sulfate; Erythromycin; Guinea Pigs; Oxytetracycline; Penicillin G; Penicillin G Procaine; Pyridazines; Sheep; Sheep Diseases; Skin Diseases; Streptomycin; Tetracycline

Topics: Acne Vulgaris; Gonorrhea; Humans; Oleandomycin; Pyoderma; Skin Diseases; Steroids; Syphilis; Tetracycline; Urethritis

Topics: Adult; Ampicillin; Bacteriological Techniques; Cephalothin; Child; Chloramphenicol; Cloxacillin; Diarrhea; Eosinophilia; Erythromycin; Haemophilus influenzae; Humans; Methicillin; Nausea; Penicillin G; Penicillin G Benzathine; Penicillin G Procaine; Penicillin V; Physician-Patient Relations; Pruritus; Respiratory Tract Infections; Skin Diseases; Staphylococcus; Streptococcus; Streptococcus pneumoniae; Sulfonamides; Tetracycline; Urticaria; Vomiting

Topics: Adult; Humans; Oleandomycin; Pyoderma; Skin Diseases; Tetracycline

Topics: Adolescent; Adult; Aged; Female; Fluorescence; Humans; Male; Middle Aged; Photosensitivity Disorders; Skin; Skin Diseases; Tetracycline

Topics: Anti-Bacterial Agents; Dermatology; Humans; Novobiocin; Protein Synthesis Inhibitors; Skin Diseases; Tetracycline

Topics: Anti-Bacterial Agents; Drug Therapy; Humans; Lymecycline; Lysine; Respiratory Tract Infections; Skin Diseases; Tetracycline; Toxicology; Urinary Tract Infections

Topics: Anti-Bacterial Agents; Humans; Novobiocin; Protein Synthesis Inhibitors; Skin Diseases; Tetracycline

Topics: Blood Chemical Analysis; Darier Disease; Demeclocycline; Dermatitis; Humans; Mycosis Fungoides; Pityriasis; Psoriasis; Skin; Skin Diseases; Sunburn; Tetracycline

Topics: Adolescent; Adult; Aged; Carcinoma, Squamous Cell; Child; Diagnosis, Differential; Fluorescence; Humans; Middle Aged; Skin Diseases; Skin Neoplasms; Tetracycline

Topics: Aged; Biliary Tract Diseases; Drug Synergism; Glucosamine; Humans; In Vitro Techniques; Male; Middle Aged; Nitrofurantoin; Skin Diseases; Surgical Wound Infection; Tetracycline

Topics: Animals; Anti-Bacterial Agents; Drug Therapy; Humans; Mollusca; Molluscum Contagiosum; Protein Synthesis Inhibitors; Skin Diseases; Tetracycline

Topics: Anti-Bacterial Agents; Dermatology; Humans; Hydrocortisone; Necrosis; Skin Diseases; Stevens-Johnson Syndrome; Tetracycline

Topics: Adrenal Cortex Hormones; Amphotericin B; Anti-Bacterial Agents; Dermatitis; Facial Dermatoses; Humans; Nasolabial Fold; Skin Diseases; Tetracycline

Topics: Anti-Bacterial Agents; Gastrointestinal Tract; Procaine; Protein Synthesis Inhibitors; Skin Diseases; Tetracycline; Tetracyclines

Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antibiotics, Antitubercular; Humans; Prednisolone; Protein Synthesis Inhibitors; Skin Diseases; Tetracycline

Topics: Anti-Bacterial Agents; Citrates; Citric Acid; Humans; Protein Synthesis Inhibitors; Skin Diseases; Tetracycline

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Novobiocin; Protein Synthesis Inhibitors; Skin Diseases; Skin Diseases, Infectious; Tetracycline

Topics: Anti-Bacterial Agents; Dermatology; Glucosamine; Humans; Protein Synthesis Inhibitors; Skin Diseases; Tetracycline

Topics: Anti-Bacterial Agents; Chloramphenicol; Dermatology; Humans; Protein Synthesis Inhibitors; Skin Diseases; Tetracycline

Topics: Anti-Bacterial Agents; Chloramphenicol; Humans; Protein Synthesis Inhibitors; Skin Diseases; Tetracycline

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Oleandomycin; Skin Diseases; Tetracycline

Topics: Anti-Bacterial Agents; Protein Synthesis Inhibitors; Skin Diseases; Skin Diseases, Bacterial; Tetracycline

Topics: Anti-Bacterial Agents; Phosphates; Protein Synthesis Inhibitors; Skin Diseases; Tetracycline

Topics: Anti-Bacterial Agents; Protein Synthesis Inhibitors; Skin Diseases; Skin Diseases, Bacterial; Tetracycline

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Oleandomycin; Protein Synthesis Inhibitors; Skin Diseases; Skin Diseases, Infectious; Tetracycline

Topics: Anti-Bacterial Agents; Humans; Micrococcus; Oleandomycin; Skin Diseases; Tetracycline

Topics: Acne Vulgaris; Anti-Bacterial Agents; Antibiotics, Antitubercular; Dermatologic Agents; Humans; Nystatin; Protein Synthesis Inhibitors; Skin Diseases; Tetracycline

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Dermatologic Agents; Novobiocin; Phosphates; Protein Synthesis Inhibitors; Skin Diseases; Tetracycline

Topics: Anti-Bacterial Agents; Humans; Protein Synthesis Inhibitors; Salts; Skin Diseases; Tetracycline; Tetracyclines

Topics: Anti-Bacterial Agents; Humans; Protein Synthesis Inhibitors; Pyoderma; Skin Diseases; Tetracycline

Topics: Administration, Topical; Anti-Bacterial Agents; Humans; Skin Diseases; Tetracycline

Topics: Anti-Bacterial Agents; Protein Synthesis Inhibitors; Skin Diseases; Tetracycline

Topics: Anti-Bacterial Agents; Bacitracin; Humans; Neomycin; Protein Synthesis Inhibitors; Skin Diseases; Tetracycline

Topics: Anti-Bacterial Agents; Chlortetracycline; Humans; Protein Synthesis Inhibitors; Skin Diseases; Tetracycline; Tetracyclines