tetracycline and Skin-Diseases--Infectious

Topics: Anti-Bacterial Agents; Anti-Infective Agents, Local; Cephalosporins; Clindamycin; Drug Combinations; Erythromycin; Humans; Methicillin; Metronidazole; Nalidixic Acid; Penicillin Resistance; Penicillins; Rifampin; Skin Diseases, Infectious; Staphylococcal Infections; Staphylococcus aureus; Sulfamethoxazole; Tetracycline; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin

Topics: Adolescent; Adult; Ampicillin; Arthritis, Infectious; Dermatitis; Endocarditis, Bacterial; Female; Gonorrhea; Humans; Male; Meningitis; Neisseria gonorrhoeae; Penicillin G; Pregnancy; Pregnancy Complications, Infectious; Sepsis; Skin Diseases, Infectious; Tetracycline

Topics: Acinetobacter; Alcaligenes; Bacitracin; Bacterial Infections; Chloramphenicol; Chromobacterium; Enterobacter; Enterobacteriaceae; Escherichia; Humans; Klebsiella; Neomycin; Penicillin Resistance; Penicillins; Polymyxins; Proteus; Pseudomonas; Silver Nitrate; Skin Diseases, Infectious; Tetracycline; Water

Efficacy of doxycycline hydrochloride administered intravenously was studied in treatment of severe purulent inflammatory diseases such as pneumonia, lung abscesses, pyothorax, skin and soft tissue infections, peritonitis, purulent cholangitis, etc.. Doxycycline showed significant advantages over tetracyclines: prolonged action, higher efficacy and good tolerance. Favourable results were observed in 85 per cent of the cases.

Topics: Adolescent; Adult; Bacterial Infections; Child; Cholecystitis; Doxycycline; Humans; Infusions, Intravenous; Peritonitis; Respiratory Tract Infections; Skin Diseases, Infectious; Tetracycline

A double-blinded study was conducted to compare the effects of mupirocin and tetracycline ointments in the treatment of skin infections. 111 patients were available for clinical assessment, of which 53 were treated with mupirocin and 58 treated with tetracycline. Clinically, both groups were improved, and there was no significant difference. Bacteriological assessment however revealed a better response to mupirocin. Staphylococcus aureus and Streptococcus pyogenes were the most common organisms isolated. 99% of Staphylococci were sensitive to mupirocin compared with 61% to tetracycline and 29% to penicillin G. 57% of Group A beta haemolytic Streptococci were resistant to tetracycline compared to 14% to mupirocin. Gram-negative organisms were mostly resistant to both preparations. No side effects were observed in both treatment groups. This study suggests that mupirocin is a safe and effective topical preparation for treating most of our common skin infections.

Topics: Adolescent; Adult; Anti-Bacterial Agents; Bacterial Infections; Clinical Trials as Topic; Double-Blind Method; Fatty Acids; Female; Humans; Male; Mupirocin; Ointments; Random Allocation; Skin Diseases, Infectious; Tetracycline

Topics: Administration, Oral; Bacterial Infections; Clinical Trials as Topic; Female; Humans; Injections, Intravenous; Male; Minocycline; Respiratory Tract Infections; Skin Diseases, Infectious; Tetracycline; Urinary Tract Infections

Topics: Adolescent; Adult; Aged; Ampicillin; Aspartate Aminotransferases; Child; Clinical Trials as Topic; Digestive System; Erythromycin; Female; Haemophilus Infections; Haemophilus influenzae; Humans; Lincomycin; Male; Methicillin; Microbial Sensitivity Tests; Middle Aged; Osteomyelitis; Penicillin Resistance; Penicillins; Respiratory Tract Infections; Sepsis; Skin Diseases, Infectious; Staphylococcal Infections; Streptococcus; Streptococcus pyogenes; Tetracycline; Time Factors

Topics: Chloramphenicol; Clinical Trials as Topic; Cloxacillin; Dermatitis; Dexamethasone; Erythromycin; Gentamicins; Humans; Kanamycin; Neomycin; Penicillin G; Penicillin Resistance; Pharmaceutic Aids; Polymyxins; Skin Diseases, Infectious; Staphylococcus; Streptococcus; Tetracycline

To investigate the destruction of clinically-relevant bacteria within biofilms via the sustained release of the antibiotic tetracycline from zein-based electrospun polymeric fibrous matrices and to demonstrate the compatibility of such wound dressing matrices with human skin cells.. Zein/PCL triple layered fibrous dressings with entrapped tetracycline were electrospun. The successful entrapment of tetracycline in these dressings was validated. The successful release of bioactive tetracycline, the destruction of preformed biofilms, and the viability of fibroblast (FEK4) cells were investigated.. The sustained release of tetracycline from these matrices led to the efficient destruction of preformed biofilms from Staphylococcus aureus MRSA252 in vitro, and of MRSA252 and ATCC 25923 bacteria in an ex vivo pig skin model using 1 × 1 cm square matrices containing tetracycline (30 μg). Human FEK4 cells grew normally in the presence of these matrices.. The ability of the zein-based matrices to destroy bacteria within increasingly complex in vitro biofilm models was clearly established. An ex vivo pig skin assay showed that these matrices, with entrapped tetracycline, efficiently kill bacteria and this, combined with their compatibility with a human skin cell line suggest these matrices are well suited for applications in wound healing and infection control.

Topics: Animals; Anti-Bacterial Agents; Biofilms; Humans; Microbial Sensitivity Tests; Polyesters; Skin; Skin Diseases, Infectious; Staphylococcal Infections; Staphylococcus aureus; Sus scrofa; Swine; Tetracycline; Zein

Summary We report a case of protothecosis in an 18-year-old female student caused by Prototheca zopfii successfully treated with amikacin combined with tetracyclines. Zusammenfassung Es wird über eine Protothecose, verursacht durch Prototheca zopfii, bei einer 18-jährigen Studentin berichtet, die erfolgreich mit Amikacin in Kombination mit Tetracyclinen behandelt wurde.

Topics: Adolescent; Amikacin; Drug Therapy, Combination; Female; Humans; Infections; Prototheca; Skin Diseases, Infectious; Tetracycline

Topics: Amphotericin B; Biopsy; Chlorella; Diagnosis, Differential; Drug Therapy, Combination; Humans; Prototheca; Skin; Skin Diseases, Infectious; Tetracycline

The in vitro antibacterial activity of the antifungal compound fenticonazole was compared with those of clotrimazole, miconazole, tetracycline, and metronidazole against 177 strains of bacterial species associated with either bacterial vaginosis (BV) or skin infections by agar dilution MIC determinations. BV-associated Bacteroides isolates of the Bacteroides melaninogenicus-B. oralis group, Gardnerella vaginalis, Mobiluncus spp., and anaerobic, gram-positive cocci were highly susceptible to fenticonazole, clotrimazole, and miconazole; but Bacteroides spp. not associated with BV, Bacteroides ureolyticus and the Bacteroides fragilis group, were resistant. All Bacteroides strains were susceptible to metronidazole, but the susceptibility of G. vaginalis and Mobiluncus spp. varied. Among the skin bacteria, Staphylococcus aureus, coryneforms, and streptococci were highly susceptible to the imidazoles; but Staphylococcus epidermidis strains were generally resistant. This antibacterial activity may give fenticonazole a useful role in the topical treatment of vaginal discharge and in mycotic skin infections that are superinfected with bacteria.

Topics: Antifungal Agents; Bacteria; Female; Humans; Imidazoles; Metronidazole; Microbial Sensitivity Tests; Skin Diseases, Infectious; Tetracycline; Vaginal Diseases

A 65-year-old woman presented with cutaneous, pruritic papules of the upper part of her chest. Histologic findings and culture of a biopsy specimen confirmed that these papules were caused by an infection with Prototheca wickerhamii, an achloric alga that rarely infects humans. Natural killer cell activity in this patient was significantly depressed before initiation of therapy. Reevaluation following successful treatment with oral tetracycline hydrochloride and topical amphotericin B cream revealed an improvement in natural killer cell activity. This patient is presented to demonstrate a rare clinical presentation of protothecosis; to document that cutaneous protothecosis can be successfully treated without the risk of toxic side effects associated with systemic antifungal agents; and to illustrate that although most patients with cutaneous protothecosis are immunosuppressed, infection with this alga appears to be at least partially responsible for the immunosuppression.

Topics: Administration, Topical; Aged; Amphotericin B; Female; Humans; Immunity, Cellular; Infections; Killer Cells, Natural; Leukocyte Count; Prototheca; Skin Diseases, Infectious; Tetracycline; Thorax

Topics: Adult; Biopsy; Borrelia Infections; Humans; Male; Skin; Skin Diseases, Infectious; Tetracycline

To test the hypothesis that the in-vivo antibiotic action of tetracycline might be affected by ferric iron and the enhancement of infection by ferric iron by tetracycline, the actions of intraperitoneal antibiotic and local ferric ammonium citrate, given separately and together, were measured in the dorsal skin of guinea-pigs bearing lesions due to staphylococci, streptococci, a Proteus sp., an Erysipelothrix sp., Clostridium perfringens, Pseudomonas aeruginosa, Aeromonas hydrophila and Klebsiella pneumoniae. Tetracycline, given in two intraperitoneal doses of 25 mg/kg at 0 and 2 h after intracutaneous challenge, maintained plasma concentrations of 4-6 micrograms/ml for more than the first 4 h of infection, after which the local lesions had become largely insusceptible to the antibiotic. The intracutaneous injection of Fe 10 micrograms in a volume of 0.1 ml containing the bacteria was sufficient to enhance infection by those strains susceptible to this effect. The in-vivo efficacy of tetracycline was not always related to low MIC; a low MIC was sometimes associated with little action and a high MIC with moderate action. Sixteen organisms were tested. The iron diminished the tetracycline effect only feebly with one staphylococcal strain and the strain of E. rhusiopathiae. In only one case, with a strain of Proteus sp., was the tetracycline action grossly diminished. On the other hand, tetracycline diminished the enhancement effect of iron moderately with three strains of staphylococci and one strain each of K. pneumoniae, P. aeruginosa and C. perfringens, and strongly with two strains of staphylococci, a group-C streptococcus and one strain each of K. pneumoniae, E. rhusiopathiae and A. hydrophila. It is evident that the diminution of tetracycline action by moderate excess of readily available Fe , whether endogenous or administered, is an unlikely event (three instances among the 16 tested) whereas the diminution of the infection-enhancing effect of iron by tetracycline is much more likely (12 instances among the 16). Insofar as a decrease in iron available for enhancement of infection is valid evidence of a diminution of the iron available for necessary physiological processes of the subject treated, our results suggest that these processes might be affected by tetracycline.

Topics: Animals; Bacterial Infections; Female; Ferric Compounds; Guinea Pigs; Iron; Quaternary Ammonium Compounds; Skin Diseases, Infectious; Tetracycline

Combination of rifampicin with trimethoprim, erythromycin, tetracycline or fusidic acid have some desirable features in the treatment of difficult infections. They are active against a very wide range of possible pathogens. Resistance to rifampicin is rare. Such combinations may be bactericidal and may be usefully synergistic. They may prevent or delay the emergence of bacterial resistant seen when some single agents are used. They can be used in patients with penicillin hypersensitivity. A series of life-threatening infections has been treated with rifampicin-containing combinations. The infections included endocarditis, meningitis, pneumonia, Legionnaire's disease, and head and neck sepsis. A major reason for the choice of drug was often penicillin hypersensitivity. A second reason was the presumption (mostly subsequently confirmed) that streptococci and/or staphylococci were implicated. The clinical outcome of these infections was generally satisfactory, with few side effects and little evidence of the emergence of antibiotic resistance.

Topics: Adolescent; Adult; Aged; Bacterial Infections; Drug Therapy, Combination; Erythromycin; Female; Fusidic Acid; Humans; Infant; Legionnaires' Disease; Male; Meningitis; Middle Aged; Osteomyelitis; Rifampin; Sepsis; Skin Diseases, Infectious; Staphylococcal Infections; Tetracycline; Trimethoprim

A four-year retrospective review of 55 patients with disseminated infections from Neisseria gonorrhoeae revealed that this complication occurs in young adults, with a predominance in women (80%). The most common manifestation of disseminated gonococcal infection was arthritis, which occurred in 47 patients (85.5%). The second most common manifestation of disseminated gonococcal infection was dermatitis, which occurred in 33 patients (60%). A thorough history, a careful physical examination, and a high index of suspicion are essential for the diagnosis. Disseminated gonococcal infection can be confirmed by isolation of gonococci from potential sites, including urethra, cervix, rectum, oropharynx, and blood. Early diagnosis and adequate therapy are necessary to prevent serious complications. The role of the gynecologist in preventing, diagnosing, and/or treating this disorder is emphasized.

Topics: Adolescent; Adult; Ampicillin; Arthritis, Infectious; Endocarditis, Bacterial; Female; Gonorrhea; Humans; Male; Menstruation; Middle Aged; Penicillin G; Pregnancy; Pregnancy Complications, Infectious; Skin Diseases, Infectious; Tetracycline

The results of typing all group A streptococci isolated in one laboratory in 5 years were reviewed to see if the collected information showed epidemiological patterns. The great majority of the 5858 streptococci typed came from patients seen in general practice: 72% from throat swabs and 11% from skin lesions. Eight types, M types 1, 2, 3, 4, 6, 12, 22 and type 28 R accounted for 65% of strains. These eight types had different patterns: types 2 and 6 caused small circumscribed outbreaks and were uncommon between epidemics; types 3, 4 and 12 caused larger, wider epidemics, whereas types 1, 22 and 28 R had a more stable pattern. Type 4 was more commonly resistant to tetracycline than most other types, a finding which affected the apparent incidence of tetracycline resistance in group A streptococci. Streptococci from superficial sites were more likely to have serum opacity factor and to lack a detectable M-antigen than strains isolated from the throat. Routine typing of streptococci helped to detect outbreaks of infection in special groups. It is concluded that regular streptococcal typing should be continued in some places.

Topics: Disease Outbreaks; Drug Resistance, Microbial; Humans; Pharynx; Seasons; Serotyping; Skin Diseases, Infectious; Streptococcal Infections; Streptococcus pyogenes; Tetracycline

A staphylococcal disperser employed as a theatre technician appeared to have been the source of 11 cases of wound sepsis over a period of about 3 years. He was primarily a nasal carrier and after attempts to eradicate Staphylococcus aureus from his nose failed, his skin dispersal was controlled by daily washing with 4% chlorhexidine detergent ('Hibiscrub') and he was allowed to resume his theatre duties under careful bacteriological surveillance. Over the following 2 years 173 dispersal tests showed a mean dispersal of 1 . 7 c.f.u. per 2800 l air compared with a mean of 152 c.f.u. per 2800 l air in the mouth immediately preceding treatment and 55 c.f.u. per 2800 l in the period after cessation of treatment. One case of wound sepsis was attributed to the technician during the 2 years in which he received skin disinfection treatment.

Topics: Chlorhexidine; Cross Infection; Humans; Male; Nasal Mucosa; Operating Room Technicians; Skin Diseases, Infectious; Staphylococcal Infections; Staphylococcus aureus; Surgical Wound Infection; Tetracycline

Topics: Humans; Skin Diseases, Infectious; Tetracycline

Topics: Acne Vulgaris; Bacterial Infections; Cellulitis; Child; Dermatitis, Exfoliative; Furunculosis; Humans; Impetigo; Infant; Infant, Newborn; Penicillins; Skin Diseases, Infectious; Staphylococcal Infections; Tetracycline; Wound Infection

Topics: Humans; Mycobacterium Infections; Skin Diseases, Infectious; Tetracycline

Topics: Adult; Amebiasis; Amebicides; Child, Preschool; Colonic Diseases; Entamoeba histolytica; Granuloma; Humans; Infant; Intestinal Perforation; Intussusception; Male; Metronidazole; Peritonitis; Skin Diseases, Infectious; Tetracycline

Five cases of Mycobacterium marinum skin infections were successfully treated with 2 gm of tetracycline hydrochloride daily for periods from four to 12 weeks. In each case, the isolated M marinum was sensitive in vitro to tetracycline at levels from 25 to 50 microgram/ml. Tetracycline is recommended as treatment for extensive or sporotrichoid M marinum infections.

Topics: 4-Aminobenzoic Acid; Adult; Ethambutol; Granuloma; Humans; Isoniazid; Male; Microbial Sensitivity Tests; Middle Aged; Mycobacterium; Mycobacterium Infections; Rifampin; Skin Diseases, Infectious; Streptomycin; Tetracycline

Topics: Acne Vulgaris; Administration, Topical; Coloring Agents; Cytarabine; Dermatologic Agents; Ethyl Ethers; Female; Glutaral; Herpes Simplex; Herpes Zoster; Humans; Ichthyosis; Injections, Intradermal; Injections, Intravenous; Male; Phototherapy; Skin Diseases, Infectious; Stomatitis, Aphthous; Tetracycline; Triamcinolone; Triamcinolone Acetonide; Urea; Vitamin A; Warts

Topics: Anti-Bacterial Agents; Bacteria; Bacterial Infections; Cephalosporins; Chloramphenicol; Conjugation, Genetic; Drug Combinations; Enzyme Repression; Erythromycin; Genetics, Microbial; Lincomycin; Male; Molecular Biology; Mutation; Neomycin; Penicillin Resistance; Penicillins; Skin Diseases, Infectious; Sulfamethoxazole; Tetracycline; Trimethoprim

Topics: Ampicillin; Anti-Bacterial Agents; England; Family Practice; Humans; Penicillin Resistance; Penicillins; Skin Diseases, Infectious; Staphylococcal Infections; Staphylococcus; Tetracycline

Topics: Aged; Humans; Male; Minocycline; Nocardia asteroides; Nocardia Infections; Skin Diseases, Infectious; Tetracycline

Topics: Humans; Minocycline; Nocardia asteroides; Nocardia Infections; Skin Diseases, Infectious; Tetracycline

Topics: Adolescent; Ampicillin; Chickenpox; Diagnosis, Differential; Drug Hypersensitivity; Erythromycin; Humans; Male; Mycoplasma; Mycoplasma Infections; Skin Diseases, Infectious; Stevens-Johnson Syndrome; Tetracycline

Topics: Abscess; Acute Disease; Adolescent; Chronic Disease; Enterobacteriaceae Infections; Granuloma; Humans; Knee; Male; Methylamines; Serratia marcescens; Skin Diseases, Infectious; Suppuration; Tetracycline

Topics: Anti-Bacterial Agents; Arthritis, Infectious; Cervix Uteri; Dermatitis; Female; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillin G; Penicillin Resistance; Skin Diseases, Infectious; Streptomycin; Syndrome; Tetracycline; Urethra; Virulence

Topics: Adult; Antibody Formation; Chlamydia; Complement Fixation Tests; Humans; Male; Penicillins; Prognosis; Psittacosis; Skin Diseases, Infectious; Tetracycline

Topics: Adolescent; Adult; Aged; Bromelains; Drug Combinations; Drug Synergism; Evaluation Studies as Topic; Female; Humans; Male; Middle Aged; Otorhinolaryngologic Diseases; Penicillin V; Respiratory Tract Infections; Skin Diseases, Infectious; Tetracycline; Urinary Tract Infections

Topics: Adolescent; Adult; Aged; Amines; Evaluation Studies as Topic; Female; Humans; Injections, Intravenous; Male; Methylamines; Middle Aged; Respiratory Tract Infections; Skin Diseases, Infectious; Tetracycline; Urinary Tract Infections

Topics: Bacteriophage Typing; Carrier State; Cross Infection; Disease Outbreaks; Erythromycin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Microbial Sensitivity Tests; Nursing Staff, Hospital; Penicillin Resistance; Penicillins; Poland; Serotyping; Skin Diseases, Infectious; Staphylococcal Infections; Staphylococcus; Staphylococcus Phages; Streptomycin; Tetracycline

Topics: Abscess; Actinomyces; Actinomycosis; Bone Diseases; Drug Resistance, Microbial; Erythromycin; Female; Humans; Middle Aged; Radiography; Skin Diseases, Infectious; Tetracycline

Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Child; Evaluation Studies as Topic; Female; Humans; Male; Methylamines; Pyoderma; Skin Diseases, Infectious; Tetracycline

Topics: Cross Infection; Drug Resistance, Microbial; Hospitals, Special; Humans; Skin Diseases, Infectious; Staphylococcus; Surgical Wound Infection; Tetracycline

Topics: Adult; Female; Humans; Infections; Male; Middle Aged; Pyrazoles; Respiratory Tract Infections; Skin Diseases, Infectious; Tetracycline

Topics: Chloramphenicol; Erythromycin; Humans; Nocardia Infections; Skin Diseases, Infectious; Tetracycline

Topics: Adolescent; Adult; Hair; Humans; Male; Skin Diseases, Infectious; Soaps; Staphylococcal Infections; Streptococcal Infections; Tetracycline

Topics: Acne Vulgaris; Adolescent; Adult; Animals; Child, Preschool; Eczema; Female; Furunculosis; Humans; Male; Mice; Microbial Sensitivity Tests; Skin Diseases, Infectious; Skin Ulcer; Staphylococcal Infections; Staphylococcus; Suppuration; Tetracycline

Two patients contracted cutaneous anthrax after contact with infected bone meal. Awareness of the risk of infection from this source may help in achieving early clinical diagnosis and a low fatality rate following effective antibiotic therapy.

Topics: Anthrax; Bacillus anthracis; Fertilizers; Humans; Male; Middle Aged; Penicillins; Skin Diseases, Infectious; Streptomycin; Tetracycline

Topics: Adolescent; Adult; Aged; Bromelains; Female; Humans; Male; Middle Aged; Pyoderma; Skin Diseases, Infectious; Tetracycline

Topics: Acne Vulgaris; Anti-Bacterial Agents; Antifungal Agents; Carbuncle; Chlortetracycline; Eczema; Erysipelas; Folliculitis; Furunculosis; Griseofulvin; Humans; Impetigo; Lupus Vulgaris; Paronychia; Penicillins; Scalp Dermatoses; Skin Diseases, Infectious; Tetracycline

Topics: Anemia; Child; Diarrhea; Enteritis; Humans; Hypothermia; Infections; Kwashiorkor; Nutrition Disorders; Penicillins; Respiratory Tract Infections; Sepsis; Skin Diseases, Infectious; Tetracycline; Urinary Tract Infections

Topics: Adult; Child; Humans; Penicillin V; Respiratory Tract Infections; Skin Diseases, Infectious; Tetracycline

Topics: Adult; Animals; Child; Demeclocycline; Humans; Mice; Oxytetracycline; Respiratory Tract Infections; Skin Diseases, Infectious; Tetracycline; Urinary Tract Infections

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Novobiocin; Protein Synthesis Inhibitors; Skin Diseases; Skin Diseases, Infectious; Tetracycline

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Oleandomycin; Protein Synthesis Inhibitors; Skin Diseases; Skin Diseases, Infectious; Tetracycline