tetracycline and Seizures

Topics: Acid-Base Equilibrium; Acute Disease; Age Factors; Bicarbonates; Body Temperature; Child; Child, Preschool; Cholera; Citrates; Coma; Feces; Furazolidone; Glucose; Humans; Hypertonic Solutions; Infusions, Parenteral; Injections, Intraperitoneal; Injections, Intravenous; Potassium; Seizures; Sodium; Tetracycline; Water-Electrolyte Balance

Topics: Adolescent; Adult; Aged; Animals; Anti-Bacterial Agents; Cephalosporins; Child; Child, Preschool; Chloramphenicol; Drug Hypersensitivity; Female; Gentamicins; Humans; Infant; Intestines; Kidney Diseases; Labyrinth Diseases; Male; Middle Aged; Optic Neuritis; Penicillins; Rabbits; Seizures; Tetracycline

Topics: Anemia, Hypochromic; Back Pain; Brain Diseases; Cerebral Ventriculography; Cerebrovascular Disorders; Child; Craniocerebral Trauma; Craniotomy; Endocrine System Diseases; Female; Genital Diseases, Female; Humans; Intracranial Pressure; Nalidixic Acid; Postoperative Complications; Pseudotumor Cerebri; Seizures; Spinal Puncture; Tetracycline; Vitamin A; Wiskott-Aldrich Syndrome

Acute cocaine intoxication is one of the important causes of admission to emergency department, especially in western countries. We aimed to compare the efficacies of tetracycline, minocycline, doxycycline in the prevention of seizures and deaths in mice due to cocaine intoxication.. In the study, a total of 120 balb-c male mice weighing 25-30 g were randomized into 4 groups as tetracycline 255 mg/kg, minocycline 170 mg/kg, doxycycline 157 mg/kg, 0.5 ml saline (placebo). The doses of tetracycline, minocycline and doxycycline are the calculated ED50 values. The mice in the groups received 93 mg/kg cocaine intraperitoneally 10 min after drug administration. The dose of cocaine is 50% of the lethal dose. After cocaine injection, all mice were observed for 30 min in terms of cocaine toxicity findings. Mortality rates, death times, seizure activities, and seizure onset times of the mice were clinically evaluated in an observational way.. There were significant differences among all the groups in terms of seizure and lethality (p < 0.001). The ratio of animals with seizures was significantly lower in the minocycline (73.3%), and doxycycline (73.3%) groups (all p = 0.040). The ratio of animals with lethality was significantly lower in the minocycline (23.3%) group compared with vehicle (p < 0.001).. In our acute cocaine intoxication model, minocycline was effective in terms of lethality and preventing seizures, doxycycline was effective in preventing seizures.

Topics: Animals; Anti-Bacterial Agents; Cocaine; Dose-Response Relationship, Drug; Doxycycline; Drug Overdose; Illicit Drugs; Male; Mice; Mice, Inbred BALB C; Minocycline; Random Allocation; Seizures; Tetracycline; Toxicity Tests; Treatment Outcome

Increasing evidence suggests the role of inflammation in enhancing neuronal excitability and contributing to epileptogenesis. Tetracycline-class antibiotics minocycline, doxycycline and tetracycline have been shown to have anti-apoptotic and anti-inflammatory effects.. We investigated the anti-seizure effects of tetracycline-class antibiotics minocycline, doxycycline and tetracycline in vivo by using the maximal electric shock (MES), 6-Hz (minimal clonic seizure) test and subcutaneous Metrazol (scMET) models of epilepsy.. Minocycline, doxycycline and tetracycline showed anticonvulsant effects in abolishing partial seizures in the mouse 6-Hz seizure test. A dose-dependent effect was found, with ED(50) of 170 mg/kg for minocycline, 157 mg/kg for doxycycline, and 255 mg/kg for tetracycline with peak onset at 0.5h. At high doses, minocycline (250 mg/kg) and doxycycline (150 mg/kg) also had toxic effects, from motor impairments to respiratory failure and death. These drugs had no effects on the MES and scMET tests.. In the three tests of anti-seizure activity, minocycline, doxycycline, and tetracycline were found to be protective in one: the 6-Hz seizure model. Our data suggest that minocycline and other tetracycline-class drugs may offer some degree of anticonvulsant effect in the setting of CNS disease trials.

Topics: Animals; Anti-Bacterial Agents; Anticonvulsants; Dose-Response Relationship, Drug; Doxycycline; Epilepsies, Partial; Male; Mice; Minocycline; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Tetracycline

Fos family transcription factors are believed to play an important role in the transcriptional responses of the brain to a variety of stimuli. Previous studies have described 35 and 37 kDa Fos-like proteins, termed chronic Fos-related antigens (FRAs), that are induced in brain in a region-specific manner in response to several chronic perturbations, including chronic electroconvulsive seizures, psychotropic drug treatments, and lesions. We show in this study that the chronic FRAs are isoforms of deltaFosB, a truncated splice variant of FosB that accumulate in brain after chronic treatments because of their stability. doffaFosB cDNA encodes the expression of 33, 35, and 37 kDa proteins that arise from a single AUG translation start site. The 35 and 37 kDa proteins correspond to the chronic FRAs that are induced in brain by chronic treatments, whereas the 33 kDa protein corresponds to a Fos-like protein that is induced in brain by acute treatments, findings based on migration on one- and two-dimensional Western blots with anti-FRA and anti-FosB antibodies. Using cells in which deltaFosB or FosB expression is under the control of a tetracycline-regulated gene expression system, we show that the 37 kDa deltaFosB protein exhibits a remarkably long half-life, the 35 kDa DeltaFosB protein exhibits an intermediate half-life, and the 33 kDa deltaFosB protein and all FosB-derived proteins exhibit relatively short half-lives. Moreover, we show that the 33 kDa deltaFosB protein is the first to appear after activation of deltaFosB expression. Finally, deltaFosB proteins are shown to possess DNA-binding activity and to exert potent transactivating effects in reporter gene assays. Together, these findings support a scheme wherein deltaFosB, expressed as a 33 kDa protein, is modified to form highly stable isoforms of 35 and 37 kDa. As a result, these stable isoforms gradually accumulate in the brain with repeated treatments to mediate forms of long-lasting neural and behavioral plasticity.

Topics: Blotting, Western; Brain; Drug Stability; Electroshock; Gene Expression; Half-Life; Isomerism; Molecular Weight; Proto-Oncogene Proteins c-fos; RNA, Messenger; Seizures; Tetracycline; Time Factors; Transcription, Genetic; Tumor Cells, Cultured

Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Alcoholism; Clindamycin; Fever; Hemoglobins; Heroin Dependence; Humans; Injections, Intramuscular; Injections, Intravenous; Length of Stay; Leukocyte Count; Lung Abscess; Male; Middle Aged; Penicillin G; Radiography; Seizures; Tetracycline; Time Factors

Topics: Acute Kidney Injury; Adult; Blood Coagulation Tests; Bronchopneumonia; Cytoplasm; Diagnosis, Differential; Disseminated Intravascular Coagulation; Female; Hepatic Encephalopathy; Humans; Liver; Liver Function Tests; Necrosis; Pneumonia; Pregnancy; Respiratory Insufficiency; Seizures; Tetracycline; Time Factors; Twins; Uric Acid

Topics: Acute Kidney Injury; Anti-Bacterial Agents; Cephalosporins; Chloramphenicol; Drug Hypersensitivity; Erythromycin; Female; Fever; Gentamicins; Humans; Hyperkalemia; Lincomycin; Methenamine; Nalidixic Acid; Nitrofurantoin; Penicillins; Photosensitivity Disorders; Polymyxins; Pregnancy; Seizures; Spectinomycin; Sulfonamides; Tetracycline

Topics: Age Factors; Autopsy; Bronchopneumonia; Child; Child, Preschool; Chlorpromazine; Female; Humans; Infant; Infant, Newborn; Kwashiorkor; Male; Measles; Penicillins; Pertussis Vaccine; Phenobarbital; Prognosis; Seizures; Tetracycline; Tuberculosis; Uganda; Vomiting; Whooping Cough

Topics: Ampicillin; Anemia, Aplastic; Child, Preschool; Chloramphenicol; Chronic Disease; Drug Hypersensitivity; Fanconi Syndrome; Female; Haemophilus influenzae; Humans; Infant; Infant, Newborn; Lung Diseases; Penicillin Resistance; Pregnancy; Seizures; Streptococcus pneumoniae; Tetracycline; Tooth Discoloration

Topics: Adolescent; Ampicillin; Child; Child, Preschool; Dysentery, Bacillary; Female; Humans; Infant; Male; Seizures; Shigella; Tetracycline

Topics: Anti-Bacterial Agents; Bacteriological Techniques; Cerebrospinal Fluid; Chloramphenicol; Colistin; Coma; Diagnosis; Epidemiology; Erythromycin; Listeria; Listeria monocytogenes; Meningitis; Meningitis, Listeria; Novobiocin; Oleandomycin; Oxytetracycline; Penicillins; Seizures; Sepsis; Serologic Tests; Spiramycin; Sulfonamides; Tetracycline

Boric acid poisoning in 11 infants, occurring in the newborn nursery as a result of the accidental and inadvertent use of 2.5% boric acid in the preparation of the formulae, is reported. Five of the infants died. All except two exhibited the classical symptomatology of acute boric acid poisoning, namely, diarrhea, vomiting, erythema, exfoliation, desquamation of the skin, and marked central nervous system irritation. Early manifestations of poisoning were nonspecific, and one patient died before skin manifestations were noted. Peritoneal dialysis, instituted in nine cases, was found to be the most effective method of treatment. It is recommended that boric acid, which is of doubtful therapeutic value, should be completely removed from hospitals, dispensaries and pharmacopoeias.

Topics: Acidosis; Anti-Bacterial Agents; Borates; Boric Acids; Color Perception Tests; Dehydration; Diarrhea; Diarrhea, Infantile; Erythema; Exchange Transfusion, Whole Blood; Gastric Lavage; Hypernatremia; Infant; Infant, Newborn; Peritoneal Dialysis; Phenobarbital; Seizures; Tetracycline; Toxicology; Vomiting