tetracycline and Sarcoidosis

Topics: Acne Vulgaris; Adult; Aged; Child, Preschool; Female; Gonorrhea; Hirsutism; Humans; Ichthyosis; Infant; Male; Melphalan; Middle Aged; Psoriasis; Sarcoidosis; Skin Diseases; Skin Neoplasms; Syphilis; Tetracycline; United States

A 60-year-old man with common variable immunodeficiency presented with a 7-year history of violaceous plaques and papules on the thighs, arms and trunk. In the preceding 2 years he had developed new lesions on both hands. He had been previously diagnosed with sarcoidosis on the basis of skin and visceral histology, but subsequent opinion was that these were sarcoid-like granulomas rather than being representative of true sarcoidosis. Biopsy of the hand lesions showed necrotizing granulomas, and a single acid-fast bacillus (AFB) was identified on Wade-Fite stain. Subsequent repeat tissue biopsies for histology, culture and polymerase chain reaction testing failed to confirm the presence of mycobacterial organisms and it was felt that the organism was a contaminant introduced during tissue processing. The hand lesions responded well to intralesional injections of triamcinolone acetonide 10 mg/mL and oral tetracycline 500 mg b.d. was later introduced with a good clinical response. The diagnostic dilemma of finding granulomatous inflammation in a patient with common variable immunodeficiency, and the significance of a single AFB on histology are discussed. The treatment of sarcoid-like granulomas with tetracycline therapy is also commented on.

Topics: Anti-Bacterial Agents; Common Variable Immunodeficiency; Diagnosis, Differential; Glucocorticoids; Granuloma; Humans; Male; Middle Aged; Sarcoidosis; Skin; Skin Diseases; Tetracycline; Tuberculosis, Cutaneous

Topics: Blepharitis; Dexamethasone; Drug Eruptions; Eyelid Diseases; Humans; Male; Middle Aged; Sarcoidosis; Tetracycline

A report on a 17-year-old patient with sarcoidosis who was admitted to hospital because of acute generalized tendency to hemorrhage in very severe thrombopenia. This type of thrombopenia has a high primary mortality rate unless steroids are administered in high doses in good time. If the patient survives this crisis, the prognosis for him and the sarcoidosis is good.

Topics: Adolescent; Adrenal Cortex Hormones; Blood Platelets; Hemoglobins; Humans; Lymph Nodes; Lymphadenitis; Male; Prognosis; Sarcoidosis; Tetracycline; Thrombocytopenia

Topics: Adult; Diagnosis, Differential; Humans; Intestine, Small; Jejunum; Lymphatic Diseases; Male; Microscopy, Electron; Radiography; Sarcoidosis; Tetracycline; Whipple Disease

Topics: Acute Disease; Adrenal Cortex Hormones; Anti-Infective Agents; Bronchitis; Doxycycline; Drug Combinations; Evaluation Studies as Topic; Female; Folic Acid Antagonists; Humans; Male; Prednisone; Pyrimidines; Sarcoidosis; Sulfamethoxazole; Tetracycline; Trimethoprim

Topics: Adult; Aged; Alopecia; Anti-Bacterial Agents; Balanitis; Biopsy; Child; Child, Preschool; Chloramphenicol; Deoxyuridine; Diagnosis, Differential; Diagnostic Errors; Erythromycin; Exanthema; Female; Hemorrhoids; Hernia, Inguinal; Herpes Simplex; Humans; Lymphadenitis; Male; Metronidazole; Middle Aged; Mycoses; Oxytetracycline; Penicillins; Sarcoidosis; Sclerosis; Skin Tests; Stomatitis; Syphilis; Syphilis Serodiagnosis; Syphilis, Latent; Tetracycline

Topics: Adult; Diagnosis, Differential; Female; Granuloma; Humans; Middle Aged; Ointments; Rosacea; Sarcoidosis; Tetracycline; Tuberculosis, Cutaneous

Topics: Animals; Animals, Laboratory; Chloramphenicol; Corynebacterium; Diagnosis, Differential; Guinea Pigs; Lung; Mice; Neomycin; Pasteurella; Penicillin Resistance; Penicillins; Rabbits; Rats; Sarcoidosis; Streptomycin; Terminology as Topic; Tetracycline

Topics: Adult; Amphotericin B; Bacteriological Techniques; Biopsy; Brain Abscess; Cerebrospinal Fluid Proteins; Hemiplegia; Humans; Isoniazid; Joint Diseases; Lung Diseases; Male; Meningitis; Nocardia Infections; Polymyxins; Prednisone; Pseudomonas Infections; Sarcoidosis; Skin Diseases; Sporotrichosis; Tetracycline

Topics: Adult; Animals; Biopsy; Blood Sedimentation; Diagnosis, Differential; Female; Fever; Granuloma; Guinea Pigs; Hodgkin Disease; Humans; Leukocytosis; Lymphadenitis; Mycobacterium tuberculosis; Pelvis; Sarcoidosis; Tetracycline; Tuberculin Test; Tuberculosis, Lymph Node