tetracycline and Renal-Insufficiency--Chronic

Patients with POAG have lower corneal endothelial cell density than healthy controls of the same age. This may be attributed to mechanical damage from elevated IOP and toxicity of glaucoma medications.. Mycophenolic acid was detected in all cats. The dose 10 mg/kg given q12h for 1 week was tolerated (n = 3). The efficacy of MMF as an immunosuppressant and long-term safety in cats of this dosage regimen is unknown.. T

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Histomorphometry or quantitative histology is the analysis on histologic sections of bone resorption, formation and structure parameters. It is the only technique allowing a dynamic evaluation of osteoblast activity after labelling with tetracycline. In addition, the use of computed image analyzer allows the possibility to assess bone microarchitecture. Histomorphometric bone biopsy is a reliable and well-tolerated procedure. Bone samples are taken at iliac crest level under local anesthesia and sedation. Samples are put into methyl-metacrilate resin where the sections are prepared for the microscopic analysis of different histomorphometric parameters. Histomorphometry is used to exclude or confirm the diagnosis of osteomalacia and also to evaluate bone damage associated with particular treatments (for example, glucocorticoids, anticonvulsants) or in case of rare bone diseases (osteogenesis imperfecta). Recently, this approach has been repurposed for the evaluation of bone disease during Chronic Kidney Disease, particularly to differentiate high and low bone turnover osteodystrophy. Kidney Disease Improving Global Outcomes (KDIGO) guidelines have pointed out the situations requiring bone biopsy for histomorphometric analysis. New techniques using molecular biology will improve the accuracy and predictive value of this approach.

Topics: Biopsy; Bone and Bones; Bone Resorption; Chronic Kidney Disease-Mineral and Bone Disorder; Forecasting; Fractures, Spontaneous; Humans; Image Processing, Computer-Assisted; Mesenchymal Stem Cells; Osteoblasts; Osteomalacia; Practice Guidelines as Topic; Renal Dialysis; Renal Insufficiency, Chronic; Tetracycline

Tetracyclines are broad-spectrum antibiotics used by dental practitioners in the treatment of periodontal disease. They generally are safe in adults. However, caution is advised in patients who have pre-existing kidney disease.. A 42-year-old woman with polycystic kidney disease received a prescription for tetracycline (250 milligrams, four times daily) after undergoing tooth extractions. She developed nausea, vomiting and diarrhea within days and end-stage renal disease within two weeks of taking the antibiotic. Hemodialysis was required to stabilize the patient's condition. Use of the Naranjo nomogram demonstrated an association between the two events.. This case illustrates the importance of obtaining a thorough medical history and understanding potential adverse drug effects before prescribing a common antibiotic.

Topics: Adult; Alveolar Bone Loss; Anti-Bacterial Agents; Dental Care for Chronically Ill; Female; Humans; Kidney Failure, Chronic; Polycystic Kidney Diseases; Renal Dialysis; Renal Insufficiency, Chronic; Tetracycline; Tooth Extraction

Topics: Anti-Bacterial Agents; Dental Care for Chronically Ill; Humans; Kidney Failure, Chronic; Renal Insufficiency, Chronic; Tetracycline; Tooth Extraction