tetracycline and Remission--Spontaneous

A group of 75 subjects with moderate or severe acne was divided by random selection into three treatment groups. One group was treated with a topically applied placebo liquid and with 500 mg of orally administered tetracycline hydrochloride daily; one group received orally administered lactose capsules and topically applied placebo liquid each day; and one group was treated with orally administered lactose capsules and with a topical preparation containing tetracycline hydrochloride and n-decylmethyl sulfoxide, an agent intended to enhance antibiotic penetration. At the conclusion of the 13-week study and at several points during the study, the conditions of the subjects receiving topically or orally administered tetracycline hydrochloride were significantly (P less than .05) more improved than the conditions of the subjects receiving lactose capsules and the topically applied placebo liquid. However, there was no significant difference between the effects of topically and orally administered tetracycline hydrochloride.

Topics: Acne Vulgaris; Administration, Oral; Administration, Topical; Adolescent; Adult; Child; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Humans; Male; Remission, Spontaneous; Tetracycline

A double-blind prospective study was undertaken to compare low-dosage tetracycline hydrochloride and clindamycin hydrate hydrochloride in the treatment of patients with pustular acne. Clinical improvement was noted in 93.7% of those receiving tetracycline and in 92.8% of those receiving clindamycin. Of those patients who were receiving clindamycin, two patients developed diarrhea and one patient developed pseudomembranous colitis. We conclude, therefore, that clindamycin should not be used as a primary drug in the treatment of acne.

Topics: Acne Vulgaris; Adolescent; Adult; Clindamycin; Clinical Trials as Topic; Colonic Diseases, Functional; Drug Administration Schedule; Female; Humans; Male; Prospective Studies; Remission, Spontaneous; Tetracycline

Topics: Acetamides; Acute Disease; Adolescent; Adult; Aged; Bronchiectasis; Bronchitis; Clinical Trials as Topic; Drug Combinations; Evaluation Studies as Topic; Female; Humans; Male; Middle Aged; Phenethylamines; Remission, Spontaneous; Respiratory Tract Infections; Sulfones; Tetracycline

Topics: Carrier State; Clinical Trials as Topic; Female; Follow-Up Studies; Humans; Male; Placebos; Recurrence; Remission, Spontaneous; Sex Factors; Tetracycline; Time Factors; Urethritis

The small-bowel mucosa of a patient with Whipple's disease in the florid state and one year after starting antibiotic treatment, in complete clinical remission was examined by the author. As a result of treatment, light-microscopic changes led to total regression. Electronmicroscopically, in the florid state, destruction of small-bowel epithelial cells was observed, mostly in the Lieberkühn's crypts. The changes of epithelial cells regressed after one year of treatment. In the lamina propria, a large amount of macrophages containing characteristic inclusions were found which persisted even after treatment. The composition of inclusions has, however, changed. The macrophages were cells poor in organelles and of a primitive differentiation. Presumably, this morphological picture is associated with the digestion incapability of cells and this may lead to the development of "acquired storage disease".

Topics: Epithelium; Humans; Inclusion Bodies; Intestinal Mucosa; Intestine, Small; Male; Middle Aged; Remission, Spontaneous; Tetracycline; Whipple Disease

Whipple's disease is characterized morphologically by macrophages in the small intestine which store PAS-postive material, as well as coarsening and atrophy of the intestinal villi, with pseudocystic cavitations. Without treatment it ends fatally due to irreversible diarrhoea and cachexia. Until 1963, only 90 cases had been diagnosed, most of them at autopsy. Intestinal biopsy has facilitated the diagnosis in life. Treatment with antibiotics results in dramitic improvement and remission for many years. From this an at least partial bacterial cause of the disease has been deducted, but it has not been possible so far to identigy more precisely any causative bacteria. Two cases of Whple's disease with some special features are reported. Both occurred in women (previous reports were almost entirely of men). The severely ill patients were cured by tetracycline within a few weeks and have remained completely well at follow-up examinations. The morphological changes in the intestinal mucosa had partially regressed.

Topics: Adult; Aged; Anti-Bacterial Agents; Atrophy; Biopsy; Diarrhea; Female; Humans; Intestinal Mucosa; Intestine, Small; Macrophages; Male; Middle Aged; Remission, Spontaneous; Sex Factors; Tetracycline; Whipple Disease

Steatosis of the liver is a harmless symptom of disturbed lipid metabolism but not a disease. The cause of the steatosis, and not the fat accumulation by itself, produces cirrhosis. There is no evidence so far in man that cirrhosis may be caused by nutritional deficiencies alone. Even cirrhosis after small bowel bypass procedures seems to be result from metabolic rather than nutritional disturbances.

Topics: Adrenal Cortex Hormones; Alcoholism; Animals; Bile Acids and Salts; Blind Loop Syndrome; Diabetes Complications; Dogs; Fatty Liver; Humans; Hyperlipidemias; Ileum; Jejunum; Kwashiorkor; Lipid Metabolism; Liver Cirrhosis; Malabsorption Syndromes; Obesity; Postoperative Complications; Protein Deficiency; Remission, Spontaneous; Tetracycline

Granuloma inguinale is an uncommon infectious granulomatous disease of the inguinale area that can insidiously engulf and mutilate tissue. The reported case of granuloma inguinale demonstrated the painless progression of the disease to destroy most penile, scrotal, and inguinal tissue and also showed the subsequent satisfactory therapeutic result with antibiotic treatment. Light microscopy of plastic-embedded thin-sectioned tissue specimens allowed clear demonstration of the Donovan bodies and may be valuable in diagnosis.

Topics: Granuloma Inguinale; Humans; Male; Middle Aged; Penis; Perineum; Remission, Spontaneous; Scrotum; Tetracycline

Topics: Administration, Oral; Adolescent; Adult; Aged; Ascorbic Acid; Child; Colitis, Ulcerative; Drug Therapy, Combination; Enema; Female; Humans; Hydrocortisone; Infusions, Parenteral; Injections, Intravenous; Male; Middle Aged; Parenteral Nutrition; Phosphates; Prednisolone; Remission, Spontaneous; Sulfasalazine; Tetracycline; Vitamin B Complex

Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Cephalothin; Granulomatosis with Polyangiitis; Humans; Immunosuppressive Agents; Male; Methylprednisolone; Remission, Spontaneous; Streptomycin; Sulfamethoxazole; Tetracycline; Trimethoprim

Topics: Adhesiveness; Blood Sedimentation; Brucella Vaccine; Brucellosis; Cell Nucleus; Centrifugation, Density Gradient; Enterobacteriaceae; Escherichia coli; Female; Golgi Apparatus; Humans; Hypersensitivity; Lysosomes; Macrophages; Microscopy, Electron; Monocytes; Phagocytosis; Remission, Spontaneous; Salmonella; Salmonella typhimurium; Skin Tests; Tetracycline

Topics: Adult; Arthritis, Reactive; Aspirin; Humans; Male; Methotrexate; Phenylbutazone; Remission, Spontaneous; Tetracycline

Topics: Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Breast Neoplasms; Carcinoma; Drug Synergism; Female; Humans; Leukemia, Myeloid, Acute; Lung; Male; Middle Aged; Neoplasm Metastasis; Ovarian Neoplasms; Prednisone; Radiography; Remission, Spontaneous; Sarcoma; Tetracycline; Vincristine

Topics: Anti-Bacterial Agents; Cervix Uteri; Doxycycline; Female; Gonorrhea; Humans; Neisseria gonorrhoeae; Rectum; Remission, Spontaneous; Tetracycline

Topics: Acne Vulgaris; Adolescent; Brain Diseases; Female; Humans; Intracranial Pressure; Papilledema; Pseudotumor Cerebri; Remission, Spontaneous; Tetracycline

Topics: Adult; Arteritis; Dental Caries; Dexamethasone; Fluorescent Dyes; Gingivitis; Humans; Hypersensitivity; Male; Phlebitis; Photography; Radiography; Remission, Spontaneous; Retinal Vessels; Rhinitis; Streptomycin; Tetracycline; Tonsillitis