tetracycline and Rectal-Diseases

Topics: Adult; Aged; Candida; Candidiasis; Candidiasis, Cutaneous; Candidiasis, Oral; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Nystatin; Penicillin G; Rectal Diseases; Tetracycline

The results of therapy in 916 men with anorectal gonorrhea treated with orally given antibiotic drugs were reviewed retrospectively. There was a 17.8 percent failure rate for tetracycline (total dose, 10 grams) and a 10.7 percent failure for 3.5 grams of ampicillin plus 1 gram of probenicid. Repeating the ampicillin plus probenicid dose once in 8 to 14 hours reduced the failure rate to 1.6 percent, an efficacy comparable to the regimen of 4.8 million units of aqueous procaine penicillin G given intramuscularly plus 1 gram of probenicid given orally for treatment of anorectal gonorrhea.

Topics: Administration, Oral; Ampicillin; Drug Combinations; Gonorrhea; Humans; Male; Probenecid; Rectal Diseases; Retrospective Studies; Tetracycline

Anorectal gonococcal infection is particularly prevalent in women and homosexual men. Although the currently recommended Public Health Service therapeutic regimens for uncomplicated gonorrhea appear to be effective also for anorectal gonorrhea in women, their efficacy for anorectal infection in men has not been adequately evaluated. We report a case of gonococcal proctitis in a homosexual man that did not respond to therapy with ampicillin plus probenecid and tetracycline, but subsequently responded to spectinomycin therapy. Currently available therapeutic regimens for anorectal gonococcal infection in males are reviewed.

Topics: Adult; Ampicillin; Anus Diseases; Gonorrhea; Humans; Kanamycin; Male; Penicillin G Procaine; Rectal Diseases; Spectinomycin; Sulfamethoxazole; Tetracycline; Trimethoprim

In a prospective controlled study of 290 men and women with uncomplicated gonorrhea, carbenicillin was shown to be less than 90% effective. Positive cultures were the basis for initial diagnosis and therapeutic failure in both sexes. Carbenicillin was evaluated in three different schedules: 5gm p.o., 10 gm p.o, and 2gm IM Plus 5GM p.o. The three schedules were equally effective. Eleven of 20 failures in women occurred in infection of the rectum. MICs of carbenicillin ranged from 0.025% to 1.0 mug/ml with a mean of 0.29 mug/ml.

Topics: Administration, Oral; Adult; Carbenicillin; Female; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Rectal Diseases; Tetracycline

Topics: Actinomyces; Actinomycosis; Aged; Anus Diseases; Colitis, Ulcerative; Crohn Disease; Diabetes Mellitus; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Male; Middle Aged; Penicillin G; Rectal Diseases; Rectal Fistula; Suppuration; Tetracycline

Topics: Aged; Bacitracin; Colectomy; Colon; Colonic Diseases; Colonic Neoplasms; Colostomy; Drug Therapy, Combination; Humans; Neomycin; Peritonitis; Postoperative Complications; Premedication; Rectal Diseases; Rectal Neoplasms; Rectum; Sepsis; Surgical Wound Infection; Tetracycline

Topics: Administration, Oral; Gonorrhea; Homosexuality; Humans; Injections, Intramuscular; Male; Neisseria gonorrhoeae; Penicillin G Procaine; Pharyngeal Diseases; Pharynx; Prospective Studies; Rectal Diseases; Rectum; Surveys and Questionnaires; Tetracycline; Urethral Diseases