tetracycline and Pyuria

In a previous study treatment with minocycline 100 mg orally every day for seven days was as effective for nongonococcal urethritis (NGU) as 200 mg for seven days or 100 or 200 mg for 21 days. In this prospective, randomised study men with NGU received tetracycline either 500 mg or 250 mg four times daily for seven days. of 200 men initially enrolled, Chlamydia trachomatis was isolated from 40% and Ureaplasma urealyticum from 48%. Eight of 10 homosexual men compared with 39 (21%) of 190 bisexual or heterosexual men had negative culture results for both C trachomatis and U urealyticum (x2 = 15.5, P < 0.0005). U urealyticum was isolated more frequently from chlamydia-negative men and from men with 10 or fewer sex partners during their lifetime. Both regimens were equally effective in their in-vivo activity against C trachomatis and U urealyticum. Failure rates were similar with the two regimens. More obvious failure with purulent or profuse mucoid discharge and pyuria occurred more frequently with the 250-mg regimen (20% of 76 men on the 250-mg regimen compared with 7% of 67 men on the 500-mg regimen; x2 = 4.45, P < 0.05). Failure occurred more frequently in men who were initially chlamydia-negative and in men in whom U urealyticum persisted after medication. Thus, the 250-mg regimen appeared to be as effective as the 500-mg regimen in the initial treatment of NGU. However, one-third of men had persistent or recurrent urethritis with these regimens, and there is a need for antimicrobial agents with greater in-vivo activity, especially against chlamydia-negative NGU.

Topics: Chlamydia trachomatis; Humans; Male; Pyuria; Sexual Behavior; Tetracycline; Ureaplasma; Urethritis

Topics: Adult; Aged; Bacterial Infections; Bacteriuria; Doxycycline; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Pyuria; Tetracycline; Urinary Tract Infections

Positive results were obtained in epithelial concentrations when tetracycline was given to 50 patients with bladder tumors. The diagnosis of bladder tumors with epithelial concentration is especially helpful in patients with hematuria and pyuria. With this technique many epithelial cells radiate a bright yellow fluorescence.

Topics: Adult; Aged; Cytodiagnosis; Epithelial Cells; Epithelium; Female; Fluorescence; Hematuria; Humans; Male; Middle Aged; Pyuria; Staining and Labeling; Tetracycline; Urinary Bladder Neoplasms

Topics: Animals; Basement Membrane; Cell Nucleus; Creatinine; Dogs; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Hematuria; Injections, Intraperitoneal; Kidney; Kidney Concentrating Ability; Kidney Cortex; Kidney Tubules, Distal; Kidney Tubules, Proximal; Mitochondria; Neoplasms; Organoids; Osmolar Concentration; Proteinuria; Pyuria; Tetracycline; Urine

Topics: Administration, Oral; Ampicillin; Doxycycline; Female; Gonorrhea; Humans; Injections; Kanamycin; Male; Mycoplasma Infections; Neisseria gonorrhoeae; Penicillin G Procaine; Penicillin Resistance; Probenecid; Pyuria; Recurrence; Sex Factors; Spectinomycin; Tetracycline; United States; Urethritis

Topics: Adolescent; Adult; Ampicillin; Anemia; Arthritis, Infectious; Arthritis, Reactive; Endocarditis, Bacterial; Female; Gonorrhea; Hepatitis; Humans; Male; Meningitis; Menstruation; Myocarditis; Neisseria gonorrhoeae; Penicillin G Procaine; Penicillin V; Pericarditis; Pregnancy; Pregnancy Complications, Infectious; Pyuria; Sepsis; Skin Diseases; Tetracycline

Topics: Adult; Bacteriuria; Basement Membrane; Biopsy; Cystitis; Female; Focal Infection; Glomerulonephritis; Hematuria; Humans; Kidney Glomerulus; Male; Mycoplasma; Proteinuria; Pyuria; Tetracycline; Urinary Bladder

Topics: Anti-Bacterial Agents; Blood Chemical Analysis; Child; Escherichia coli Infections; Humans; Infant; Infant, Newborn; Leukocyte Count; Nitrofurantoin; Proteinuria; Pyelonephritis; Pyuria; Tetracycline; Urea; Urine; Urography

Topics: Adolescent; Albuminuria; Diagnosis, Differential; Glycerol; Glycosuria; Humans; Infusions, Parenteral; Ketone Bodies; Kidney; Lactates; Lupus Erythematosus, Systemic; Photosensitivity Disorders; Pyuria; Renal Aminoacidurias; Tetracycline; Toxicology