tetracycline and Pulmonary-Eosinophilia

It were Liebow et al. (1965) who, for the first time, described the desquamative interstitial pneumonia (DIP) as one clinical and morphological unit. The etiopathology of this disease is still unknown and there exist many controversial opinions as to its role within the interstitial pneumonias. For the clinical-physician the DIP represents a difficult problem because there seems to be no uniform appearance to this disease. So a lung-biopsy is the unique way to make a definitive diagnosis. The following description represents a case of DIP observed at our hospital. At the same time we tried to give a review of our present knowledge concerning the morphology, course and therapy of this disease. We think it should be note that the DIP was accompanied by an extreme peripheral eosinophilia. To our knowledge this is the first time such a phenomenon is described. In the course of the treatment with steroids the eosinophilia disappeared parallel to the normalization of the radiographic findings.

Topics: Adrenal Cortex Hormones; Adult; Alveolitis, Extrinsic Allergic; Collagen Diseases; Diagnosis, Differential; Eosinophilia; Female; Histiocytosis, Langerhans-Cell; Humans; Isoniazid; Lung; Pneumonia; Pulmonary Eosinophilia; Radiography; Rifampin; Tetracycline

Topics: Aged; Biopsy, Needle; Chronic Disease; Diagnosis, Differential; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique, Direct; Follow-Up Studies; Humans; Immunohistochemistry; Niacinamide; Pemphigoid, Bullous; Prednisolone; Prurigo; Pulmonary Eosinophilia; Risk Assessment; Severity of Illness Index; Tetracycline; Treatment Failure

A study is presented of 16 patients with eosinophilic lesions of the lungs due to drug treatment. The disease was characterized by a reduction of T-lymphocytes, inhibition of the enzymatic activity of leucocytes, dysproteinemia with hypergammaglobulinemia and reduction of IgG concentration. Patients with a high eosinophilia in the blood revealed a severe course of the disease with polysystemic involvement. The therapeutic effect was achieved only by means of prednisolone monotherapy. At the remote period they developed as a rule bronchial asthma. Patients with moderate eosinophilia showed a more favourable course, treatment proved successful with employment of nonsteroid anti-inflammatory agents, antihistaminic drugs in combination with nondrug treatment.

Topics: Cromolyn Sodium; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Penicillins; Pulmonary Eosinophilia; Sulfanilamides; Tetracycline

Topics: Administration, Oral; Adult; Female; Humans; Pulmonary Eosinophilia; Radiography; Respiratory Function Tests; Tetracycline

Topics: Acne Vulgaris; Administration, Oral; Adult; Carbon Dioxide; Female; Humans; Male; Minocycline; Oxygen; Pulmonary Eosinophilia; Radiography; Tetracycline; Tetracyclines; Urinary Tract Infections

Topics: Female; Humans; Middle Aged; Pulmonary Eosinophilia; Tetracycline