tetracycline and Pruritus

The metronidazole resistance of Helicobacter pylori strains has increased rapidly.. To evaluate the efficacy and safety of new 1-week regimens containing ranitidine bismuth citrate, furazolidone and either amoxicillin or tetracycline.. One hundred and twenty patients with H. pylori-positive inactive duodenal ulcer or non-ulcer dyspepsia diagnosed by endoscopy were recruited randomly to receive one of two regimens for 7 days: ranitidine bismuth citrate, 350 mg b.d., furazolidone, 100 mg b.d., and either amoxicillin, 1000 mg b.d. (n=60), or tetracycline, 500 mg b.d. (n=60). H. pylori infection was identified by rapid urease testing and histology. 13C-Urea breath test was performed to evaluate the cure of H. pylori infection at least 4 weeks after completion of triple therapy.. The eradication rates of H. pylori by ranitidine bismuth citrate-furazolidone-amoxicillin and ranitidine bismuth citrate-furazolidone-tetracycline regimens were 82% and 85% (P > 0.05), respectively, by intention-to-treat analysis, and 85% and 91% (P > 0.05), respectively, by per protocol analysis. Adverse effects were mild in both ranitidine bismuth citrate-furazolidone-amoxicillin and ranitidine bismuth citrate-furazolidone-tetracycline groups.. One-week regimens containing ranitidine bismuth citrate, furazolidone and amoxicillin or tetracycline are well tolerated and effective for the eradication of H. pylori.

Topics: Adolescent; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Anti-Ulcer Agents; Bismuth; Diarrhea; Dizziness; Double-Blind Method; Drug Therapy, Combination; Exanthema; Female; Furazolidone; Helicobacter Infections; Helicobacter pylori; Humans; Male; Middle Aged; Penicillins; Prospective Studies; Pruritus; Ranitidine; Tetracycline; Treatment Outcome; Vomiting

Tetracycline and niacinamide were administered in combination to 19 atopic dogs to determine their effectiveness in controlling pruritus. The pruritus was controlled successfully in only one dog. One dog experienced diarrhea that was severe enough to warrant stopping the medication.

Topics: Animals; Anti-Bacterial Agents; Diarrhea; Dog Diseases; Dogs; Drug Therapy, Combination; Hypersensitivity, Immediate; Niacinamide; Pruritus; Tetracycline; Treatment Outcome

In a multicentre, double-blind, controlled trial of tetracycline plus nystatin (Mysteclin) and tetracycline, 111 patients with respiratory infections received one or other drug for a period of 10 days.The incidence of gastrointestinal symptoms was high in both groups before treatment began, and somewhat higher in the Mysteclin group than in the tetracycline group. After 10 days' treatment 50% of the patients in the Mysteclin group had symptoms, a mean of 1.44 each, compared with 34% of the patients in the tetracycline group, with a mean of 1.47 symptoms each; the difference between the two groups is not significant (P>0.05). The incidence of Candida albicans in the stools at 10 days in the Mysteclin group (9.1%) was significantly lower than that in the tetracycline group (37.1%), but this was not reflected in any reduction in the frequency of gastrointestinal symptoms.

Topics: Candida; Clinical Trials as Topic; Diarrhea; Feces; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Nystatin; Pruritus; Respiratory Tract Infections; Sex Factors; Tetracycline

Topics: Administration, Cutaneous; Anti-Bacterial Agents; Biopsy; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique, Indirect; Glucocorticoids; Humans; Male; Middle Aged; Niacinamide; Pemphigoid, Bullous; Predictive Value of Tests; Pruritus; Sensitivity and Specificity; Tetracycline; Torso; Treatment Outcome; Vitamin B Complex

To explore whether intestinal microflora plays a role in anti-pruritic activity of baicalin, a main constituent of the rhizome of Scutellaria baicalensis (SB).. Baicalin was anaerobically incubated with human fecal microflora, and its metabolites, baicalein and oroxylin A, were isolated. The inhibitory effect of baicalin and its metabolites was accessed in histamine- or compound 48/80-induced scratching behavior in mice.. Baicalin was metabolized to baicalein and oroxylin A, with metabolic activities of 40.2+/-26.2 and 1.2+/-1.1 nmol.h(-1).mg(-1) wet weight of human fecal microflora, respectively. Baicalin (20, 50 mg/kg) showed more potent inhibitory effect on histamine-induced scratching behavior when orally administered than intraperitoneally. In contrast, baicalein and oroxylin A had more potent inhibitory effect when the intraperitoneally administered. The anti-scratching behavior activity of oral baicalin and its metabolites was in proportion to their inhibition on histamine-induced increase of vascular permeability with oroxylin A more potent than baicalein and baicalin. In Magnus test using guinea pig ileum, oroxylin A is more potent than baicalein and baicalin in inhibition of histamine-induced contraction. The anti-scratching behavioral effect of oral baicalin was significantly reduced when oral antibiotics were simultaneously administered, whereas the effect of baicalein and oroxylin A were not affected.. Oral baicalin may be metabolized by intestinal microflora into baicalein and oroxylin A, which ameliorate pruritic reactions through anti-histamine action.

Topics: Animals; Anti-Bacterial Agents; Antipruritics; Feces; Flavanones; Flavonoids; Guinea Pigs; Histamine; Histamine Antagonists; Intestines; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Phytotherapy; Pruritus; Scutellaria baicalensis; Streptomycin; Tetracycline

This report describes two cases of palpebral localisation of Tunga penetrans.. Two Congolese patients (a 17-year-old black man and a 12-year-old black girl) presented with a history of itching and oedema of the left upper eyelid.. On inspection and slit lamp examination, the patients manifested the characteristic lesion of a white translucent papule with a central black pit. Scraping of the lesion revealed a gravid adult female flea, allowing the diagnosis of infection with the flea T. penetrans. After removal of the parasite, a complete local recovery occurred over a 1-week period with local application of tetracycline.. With the increase in international travelling, it is useful to know that eyelid localisation of T. penetrans is possible.

Topics: Adolescent; Animals; Child; Ectoparasitic Infestations; Edema; Eyelid Diseases; Eyelids; Female; Humans; Male; Ophthalmologic Surgical Procedures; Pruritus; Siphonaptera; Tetracycline

Topics: Acne Vulgaris; Adrenal Cortex Hormones; Adult; Blister; Contraceptives, Oral; Cosmetics; Dermatologic Agents; Drug Eruptions; Eczema; Facial Dermatoses; Female; Fusobacterium; Humans; Male; Pruritus; Rosacea; Tetracycline; Vitamin B Deficiency

Topics: Cholestasis; Contraceptives, Oral; Fatty Liver; Female; Humans; Jaundice; Pregnancy; Pregnancy Complications; Pruritus; Tetracycline

Topics: Adult; Drug Eruptions; Humans; Male; Middle Aged; Oxytetracycline; Pruritus; Tetracycline

Topics: Administration, Oral; Drug Hypersensitivity; Erythema; Humans; Pruritus; Skin Diseases; Tetracycline

Topics: Adult; Cholestasis; Female; Hepatitis; Humans; Postoperative Complications; Pruritus; Tetracycline; Transaminases

Topics: Adult; Ampicillin; Bacteriological Techniques; Cephalothin; Child; Chloramphenicol; Cloxacillin; Diarrhea; Eosinophilia; Erythromycin; Haemophilus influenzae; Humans; Methicillin; Nausea; Penicillin G; Penicillin G Benzathine; Penicillin G Procaine; Penicillin V; Physician-Patient Relations; Pruritus; Respiratory Tract Infections; Skin Diseases; Staphylococcus; Streptococcus; Streptococcus pneumoniae; Sulfonamides; Tetracycline; Urticaria; Vomiting