tetracycline and Porphyrias

Topics: Acne Vulgaris; Alopecia Areata; Dermatitis, Contact; Humans; Lupus Erythematosus, Systemic; Lymphatic Diseases; Methotrexate; Ointments; Photosensitivity Disorders; Porphyrias; Psoriasis; Rosacea; Skin Diseases; Steroids; Sunscreening Agents; Tetracycline; Tinea; Trichophyton; Urea; Vitiligo

Topics: Alcoholism; Bloodletting; Female; Furosemide; Humans; Hydroxychloroquine; Kidney Failure, Chronic; Male; Nalidixic Acid; Porphyrias; Skin Diseases; Terminology as Topic; Tetracycline

Five patients manifested cutaneous changes indistinguishable from those noted in some porphyric disorders, consisting of fragility, denudation, and blister formation of sun-exposed skin. Microscopical examination showed subepidermal bulla formation and the desposition of PAS-positive, diastase-resistant material and IgG in or around the upper dermal blood vessel walls. There was also electron microscopical evidence of vascular basal lamina reduplication and the deposition of a fine fibrillar material in and around these vessels. However, no abnormal porphyrin formation was noted. All five patients had been receiving 250 mg of tetracycline hydrochloride twice a day for at least six months and had had extensive sun exposure prior to the onset of the condition. For four patients, discontinuing the medication led to complete remission, despite subsequent sun exposure; the fifth patient was much improved, but her skin was still somewhat fragile seven months later. We concluded that these cutaneous changes resulted from a low-grade photosensitization by tetracycline hydrochloride.

Topics: Acne Vulgaris; Adolescent; Adult; Erythrocytes; Female; Humans; Microscopy, Electron; Microscopy, Fluorescence; Photosensitivity Disorders; Porphyrias; Porphyrins; Skin; Sunlight; Tetracycline

Topics: Child; Dental Caries; Dental Enamel Hypoplasia; Dental Pulp Necrosis; Dentinogenesis Imperfecta; Female; Humans; Infant, Newborn; Jaundice, Neonatal; Porphyrias; Pregnancy; Pregnancy Complications; Tetracycline; Tooth Discoloration

Topics: Adolescent; Erythropoiesis; Female; Fluorescence; Humans; Oral Manifestations; Photography; Photomicrography; Porphyrias; Spectrophotometry; Tetracycline; Tooth; Tooth Discoloration; Ultraviolet Rays

Topics: Adult; Child; Fluorescence; Humans; Maryland; Michigan; Middle Aged; Porphyrias; Tetracycline; Tooth Discoloration; Ultraviolet Rays