tetracycline and Peritoneal-Diseases

Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Female; Humans; Peritoneal Diseases; Tetracycline; Tissue Adhesions

A total of 1504 consecutive abdominal operations were studied prospectively over a five year period. The incidence of wound (2.8%) and intraperitoneal (0.8%) infections was low compared with contemporary reports. It is difficult to justify modifying existing practice on the basis of small controlled clinical trials when information from accurate audit discloses results superior to those of experimental studies.

Topics: Abdomen; Abscess; Gastrointestinal Diseases; Humans; Peritoneal Diseases; Prospective Studies; Staphylococcal Infections; Surgical Wound Infection; Tetracycline

Topics: Animals; Peritoneal Diseases; Rats; Tetracycline; Therapeutic Irrigation; Tissue Adhesions

The clinical efficacy of tetracycline lavage (1 mg/ml) in the management of abdominal sepsis has led to advocacy of its use in potentially contaminated cases. Yet at higher concentrations (6 mg/ml), tetracycline is a pleural sclerosant. The possibility of early ultrastructural peritoneal damage and later adhesion formation has been examined in syngeneic female Wag rats. At high concentration (10 mg/ml), tetracycline caused adhesions in the absence of peritoneal trauma and there was an associated loss of serosal microvilli. Lavage with low concentration tetracycline (1 mg/ml) or saline after clean abdominal surgery led to more adhesions than if no lavage was employed. There was an unexplained paradoxically low incidence of adhesions if prior mild contamination of the peritoneal cavity with 1 ml 10(5) E. coli had been performed.

Topics: Animals; Female; Microscopy, Electron; Microvilli; Peritoneal Diseases; Peritoneum; Rats; Rats, Inbred Strains; Tetracycline; Therapeutic Irrigation; Tissue Adhesions

Topics: Abdomen; Abscess; Child; Humans; Peritoneal Diseases; Peritonitis; Postoperative Complications; Surgical Wound Infection; Tetracycline; Therapeutic Irrigation

Topics: Actinomyces; Actinomycosis; Actinomycosis, Cervicofacial; Adolescent; Adult; Aged; Female; Humans; Lung Diseases; Male; Middle Aged; Mycetoma; Peritoneal Diseases; Tetracycline

Topics: Animals; Anti-Bacterial Agents; Bacteria; Chloramphenicol; Chlortetracycline; Dihydrostreptomycin Sulfate; Enterococcus faecalis; Erythromycin; Escherichia coli; Freund's Adjuvant; L Forms; Mice; Mycoplasma; Oxytetracycline; Penicillin G; Peritoneal Diseases; Polymyxins; Proteus; Salmonella; Staphylococcus; Tetracycline

Topics: Abscess; Ampicillin; Cephalothin; Chloramphenicol; Enterobacter; Escherichia coli; Haemophilus influenzae; Humans; Imidazoles; Infections; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillin G; Penicillins; Peritoneal Diseases; Proteus; Pseudomonas aeruginosa; Respiratory Tract Infections; Sepsis; Staphylococcus; Streptococcus; Streptococcus pneumoniae; Surgical Wound Infection; Tetracycline; Urinary Tract Infections; Vascular Diseases; Wound Infection