tetracycline and Periapical-Periodontitis

Large apical radiolucencies after endodontic treatment are usually advised orthograde retreatment, apical surgery and that too with a guarded prognosis. Microsurgical techniques, the use of ultrasonic and magnification aides, have been in use in the developed countries for the past few decades and have shown significant improvement in long-term success of such cases. MTA is proposed as one of the best materials for sealing root end surfaces. In this report, the healing response of cases of 2 large apical radiolucencies, found separately in the anterior maxilla, which were treated by orthograde as well as retrograde endodontic treatments and guided tissue regeneration techniques.

Topics: Aluminum Compounds; Anti-Bacterial Agents; Bacterial Infections; Biopsy; Calcium Compounds; Drug Combinations; Female; Guided Tissue Regeneration; Humans; Oxides; Periapical Periodontitis; Radicular Cyst; Root Canal Filling Materials; Root Canal Obturation; Root Canal Therapy; Silicates; Tetracycline; Treatment Outcome; Young Adult

An evaluation is made of bacterial species and susceptibility to various antibiotics used in application to odontogenic infections of periapical location and in pericoronitis of the lower third molar, with the aim of optimizing the antibiotherapy of such infections and thus preventing unnecessary side effects and over-treatment.. Sixty-four patients with odontogenic infection were selected on the basis of a series of inclusion and exclusion criteria. Samples were collected from lesions under maximally aseptic conditions, avoiding oral saprophytic contamination. The samples were cultured and incubated under aerobic and anaerobic conditions, followed by bacteriological identification and antibiotic susceptibility testing.. A total of 184 bacterial strains were isolated and identified, comprising grampositive facultative anaerobes (68%), gramnegative strict anaerobes (30%) and grampositive facultative anaerobes (2%). Regardless of the origin of the odontogenic infection, the causal bacteria yielded the best results in terms of increased sensitivity and lesser resistance with amoxicillin / clavulanate and amoxicillin, respectively (p<0.05).. There are increasingly numerous reports in the literature of growing bacterial resistance to antibiotics in infectious processes affecting non-buccodental territories. This same tendency has not been observed in relation to oral infections, though important resistance has been documented for certain concrete antibiotics. According to our results, the common-use antibiotics with the greatest sensitivity and lowest resistance were shown to be amoxicillin/clavulanate followed by amoxicillin alone.

Topics: Acetamides; Adolescent; Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bacteria, Anaerobic; Clindamycin; Drug Resistance, Bacterial; Female; Focal Infection, Dental; Humans; Linezolid; Male; Metronidazole; Microbial Sensitivity Tests; Middle Aged; Molar, Third; Oxazolidinones; Periapical Periodontitis; Pericoronitis; Tetracycline

The use of systemic penicillin after an avulsion injury has been recommended to decrease the occurrence of resorption complications. Tetracycline antibiotics have been reported to possess anti-resorptive properties in addition to their anti-microbial actions. The purpose of this study was to evaluate histologically the effect of systemically administered tetracycline and amoxicillin on the inhibition of resorption due to attachment damage after replantation of dogs' teeth. Thirty-one roots from the teeth of four beagle dogs were endodontically treated to inhibit subsequent inflammatory root resorption of pulpal origin. They were then extracted and left to bench dry for 1 h to ensure severe periodontal ligament damage before replantation. For the teeth in the experimental groups, two dogs were given tetracycline hydrochloride and the other two dogs were given amoxicillin, administered orally, on the day of extraction/replantation and for the following 6 days. The control group were teeth in these animals treated in the same manner but where no antibiotics had been given. After 12-16 weeks, the dogs were sacrificed and histological sections were prepared and evaluated for complete healing, inflammatory and replacement root resorption, and the groups were compared. It was shown that healing in the amoxicillin and the control groups was poor (10.90% and 11.28%, respectively), while for the tetracycline group, 35.45% showed complete healing. Individual teeth with over 50% complete healing sites were considered as having good healing, and significantly more of these teeth were found in the tetracycline group (5 of 11 teeth) compared to the amoxicillin (1 of 11 teeth) or control group (1 of 8 teeth).

Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Chi-Square Distribution; Dogs; Evaluation Studies as Topic; Penicillins; Periapical Periodontitis; Periodontium; Root Resorption; Statistics, Nonparametric; Tetracycline; Tooth Avulsion; Tooth Replantation; Wound Healing