tetracycline and Pain--Postoperative

Postoperative wound seromas are a frequent and troublesome occurrence after mastectomy. Recent reports have suggested the efficacy of topical sclerosants at reducing their formation.. A prospective, randomized, double-blinded trial was performed to examine the effect of intraoperatively administered topical tetracycline on the occurrence of postoperative mastectomy seromas. Thirty-two women were randomized to the control arm (normal saline) and 30 women to the tetracycline arm. In the treatment group, 100 ml (2 g) of tetracycline solution was administered topically to the chest wall and skin flaps prior to skin closure. The control group received an equal volume of normal saline. Patients were monitored for the development of postoperative wound seroma.. There were no significant differences between groups regarding total volume of closed suction drainage, numbers of patients leaving hospital with drains in place, or duration of catheter drainage. Seroma formation 2 weeks postoperatively was greater in the tetracycline group than the control group (53% vs. 22%, P = 0.01). There were no differences between groups regarding the degree of postoperative pain, wound infection, or seroma formation 1 month postoperatively.. Topical tetracycline is not effective at preventing post-mastectomy wound seromas.

Topics: Administration, Topical; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Noninfiltrating; Catheterization; Chi-Square Distribution; Double-Blind Method; Drainage; Exudates and Transudates; Female; Follow-Up Studies; Humans; Intraoperative Care; Mastectomy, Modified Radical; Pain, Postoperative; Prospective Studies; Protein Synthesis Inhibitors; Sclerosing Solutions; Sclerotherapy; Sodium Chloride; Suction; Surgical Wound Infection; Tetracycline

Our objective was to study whether the placement of intra-alveolar tetracycline prevents dry sockets or improves the postoperative period.. A comparative clinical study of the surgical removal of 200 impacted mandibular third molars is made, with particular reference to postextraction pain, inflammation, trismus, and the incidence of dry socket. In 50% of these cases, a pharmacologic preparation that includes tetracycline was placed in the socket after removal of the impacted molar.. Dry socket was diagnosed in 4 cases (2%), with no relation to intra-alveolar tetracycline placement being observed. The patients who were administered intra-alveolar tetracycline had less pain and trismus and consumed fewer analgesics than the patients who received no such treatment, although statistical significance was not reached.. The intra-alveolar placement of tetracycline compound after the surgical removal of impacted mandibular third molars did not affect the incidence of dry socket.

Topics: Administration, Topical; Adult; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Dipyrone; Drug Combinations; Dry Socket; Female; Follow-Up Studies; Humans; Male; Mandible; Molar, Third; Pain, Postoperative; Tetracaine; Tetracycline; Tooth Extraction; Tooth Socket; Trismus