tetracycline and Otitis-Media

Topics: Acute Disease; Child; Child, Preschool; Chlorpheniramine; Chronic Disease; Ear, Middle; Enterobacteriaceae Infections; Gentamicins; Haemophilus Infections; Humans; Infant; Methicillin; Otitis Media; Recurrence; Streptococcal Infections; Tetracycline; Tympanic Membrane

Topics: Acute Disease; Anti-Bacterial Agents; Bacitracin; Bronchitis; Chloramphenicol; Chronic Disease; Ear Diseases; Humans; Labyrinth Diseases; Laryngitis; Neomycin; Novobiocin; Otitis Externa; Otitis Media; Penicillins; Pneumococcal Infections; Polymyxins; Respiratory Tract Infections; Staphylococcal Infections; Streptococcal Infections; Streptomycin; Tetracycline; Tonsillitis; Tracheal Diseases

Seven-day courses of either pivmecillinam 200 mg plus pivampicillin 250 mg (Miraxid) or a combination of tetracycline hydrochloride, chlortetracycline hydrochloride and demeclocycline hydrochloride (Deteclo) 300 mg, both given twice daily, were compared in a multicentre general practice study in 408 patients with symptoms of upper or lower respiratory tract infection. Patients were stratified into four diagnostic groups: sinusitis, otitis media, throat infections, and acute bronchitis and randomly allocated to treatment within these groups. Assessment at 7 days showed no difference in clinical efficacy between the two treatments where 193 of the 208 infections receiving Miraxid (93%) were rated as either cured or improved compared with 181 of the 201 infections treated with Deteclo (90%). At 7 days, the percentage of patients completely free of symptoms was the same for both groups (66%). The mean time for symptoms to clear was 3.9 days in the Miraxid group and 4.0 days in the Deteclo group. Side-effects were reported by significantly fewer patients in the Miraxid group (9.3%) than the Deteclo group (17.5%) (p less than 0.05) and six patients in the latter group failed to complete the course of treatment. Miraxid given twice daily for respiratory tract infections is as effective as Deteclo but causes significantly fewer side-effects.

Topics: Adolescent; Adult; Aged; Amdinocillin; Amdinocillin Pivoxil; Ampicillin; Bronchitis; Child; Chlortetracycline; Demeclocycline; Drug Combinations; Family Practice; Female; Humans; Male; Middle Aged; Otitis Media; Pharyngeal Diseases; Pivampicillin; Respiratory Tract Infections; Sinusitis; Tetracycline

Topics: Ampicillin; Anti-Bacterial Agents; Candida; Child, Preschool; Chronic Disease; Erythromycin; Exudates and Transudates; Haemophilus Infections; Haemophilus influenzae; Humans; Micrococcus; Neisseria; Otitis Media; Penicillin Resistance; Penicillins; Placebos; Retrospective Studies; Staphylococcal Infections; Streptococcal Infections; Sulfonamides; Tetracycline; Time Factors; Tympanic Membrane

Topics: Adolescent; Adult; Aged; Child; Clinical Trials as Topic; Erythromycin; Female; Furunculosis; Humans; Male; Middle Aged; Otitis Media; Pharyngitis; Tetracycline

During 1995 and 1996, 393 and 566 strains of Streptococcus pneumoniae, isolated from acute otitis media, were respectively sent to the National Reference Center for Pneumococci by its corresponding centers.. The resistance rates for 1995 and 1996 were respectively: for penicillin: 65.4 and 70.3% (18.6 and 24.9% of intermediately resistant strains, 46.8 and 45.4% of fully resistant strains), for erythromycin: 57.5 and 68.5%, for tetracycline: 43.2 and 42.6%, for trimethoprim-sulfamethoxazole: 47.5 and 50.9%. Minimal inhibitory concentrations (MICs) of various betalactams were determined against a representative sample of strains (n = 99).. Amoxicillin, cefpodoxime and cefuroxime MICs remained low against numerous penicillin resistant strains, indicating that these three oral antibiotics (in combination with clavulanate for amoxicillin) have a useful potential for the treatment of acute otitis media when risk factors for pneumococcal penicillin-resistant infections are detected.

Topics: Acute Disease; Amoxicillin; beta-Lactam Resistance; beta-Lactams; Cefpodoxime; Ceftizoxime; Cefuroxime; Erythromycin; France; Humans; Microbial Sensitivity Tests; Otitis Media; Penicillin Resistance; Penicillins; Pneumococcal Infections; Serotyping; Streptococcus pneumoniae; Tetracycline; Trimethoprim, Sulfamethoxazole Drug Combination

The inbred CBA/J mouse has become a standard experimental animal for auditory study because of its lifelong good hearing. In a newly established mouse breeding colony that housed CBA/J and CBA/CaJ mice to reared as auditory subjects, otitis media frequently afflicted CBA/J mice, reaching an incidence of 90% in animals greater than 400 days of age. Otitis media was not found in CBA/CaJ mice. Three attempts to establish a colony that was free of otitis were unsuccessful. Although the primary pathogen was not clearly established, Pasteurella pneumotropica was isolated from infected bullae. Partial control of otitis media followed the introduction of tetracycline prophylaxis. The CBA/CaJ mice may be suitable replacements for CBA/J mice in studies that require inbred mice with good hearing, since their auditory thresholds did not differ significantly from those of otitis-free CBA/J mice.

Topics: Animals; Auditory Threshold; Evoked Potentials, Auditory, Brain Stem; Labyrinthitis; Mice; Mice, Inbred CBA; Otitis Media; Pasteurella Infections; Species Specificity; Tetracycline

The problem of a replacement material for the reconstruction of the posterior wall of the auditory canal, as well as for the obliteration of the radical cavity has not been solved satisfactor;ly so far. In order to examine the possible applicability of porous plastics, the posterior wall of the auditory canal of guinea pigs was first removed and then reconstructed using porous polyethylene and filling the bulla tympanica with fine polyethylene chips. One third of the animals had an infected middle ear at the time of implantation. Histologic assessments were made until 24 weeks after implantation. In 80% of the animals the implant settled well, even in cases where the middle ears had been originally infected. By proliferation of vessels and connective tissue, the polyethylene had almost been completely integrated into the surrounding tissue after one week. Extent and frequency of metaplastic osseous growth was greater inthe chip-filled bulla than in the reconstructedposterior wall(Fig. 9). After four weeks, the new osteoid substance was firmly connected with the regional bone (Fig. 4). According to these results, it would seem possible to use porous polyethylene even for the nonaseptic implant bed as it is found in the chronically infected middle ear.

Topics: Animals; Bone Development; Drug Evaluation, Preclinical; Ear Canal; Guinea Pigs; Otitis Media; Polyethylenes; Tetracycline; Time Factors; Tympanoplasty

During the winter months 1974/75 we were able to observe a number of unusual respiratory tract infections particularly in children over 6 years of age which appeared as pneumonias. Characteristic clinical findings included a dry, hacky cough, refractive to the usual antitussives, starting 1--2 weeks prior to admission, fever up to 104, malaise, headache, anorexia, shortness of breath and cyanosis. Several Pts were treated prior to admission with a number of antibiotics and failed to respond. Laboratory findings showed a peripheral polymorphonuclear leucocytosis with toxic granulations of neutrophiles. A sedimentation rate above 40 in the first hour occurred in most Pts. X Ray of the lung revealed a characteristic mottled appearance with patchy infiltrations, atelectasis and nodular densities. Frequently a shift of the mediastinum towards the infiltrate was seen. One of the hallmarks on physical examination was the discrepancy between the severity of the clinical illness and the paucity of physical findings. Decreased breath sounds over affected lung areas were often the only findings on auscultation; find rales, rhonchi or dullness on percussion were less often heard. The combination of a typical history, physical examination, laboratory tests and X Ray findings enabled us to make a presumptive clinical diagnosis of Mycoplasma pneumonia before serologic test results were available and to start with the appropriate antibiotic (Erythromycin, Tetracycline) early in the course of the disease. Complement fixation tests with a titer of 1 : 20 and a fourfold rise over the next two weeks or an initial titer of 1 : 80 and above were considered significant for acute disease.

Topics: Adolescent; Child; Child, Preschool; Erythromycin; Female; Humans; Male; Mycoplasma Infections; Otitis Media; Pneumonia; Rhinitis; Serologic Tests; Sinusitis; Tetracycline; Tonsillitis

Antibiotic therapy has been shown to be of no value in the treatment of the URI--either in shortening the course of the acute illness or in preventing the development of secondary bacterial infections. Patient expense, as well as the threat of adverse reactions, should prohibit the present practice by some of routinely prescribing tetracycline, erythromycin, and ampicillin. Indiscriminate antibiotic therapy cannot substitute for proper diagnostic evaluation of the patient who may have either a bacterial or, far more likely, a viral illness.

Topics: Ampicillin; Anti-Bacterial Agents; Chloramphenicol; Diagnosis, Differential; Diarrhea; Guaiacol; Humans; Mycoplasma Infections; Otitis Media; Penicillin V; Penicillins; Pharyngitis; Prospective Studies; Respiratory Tract Infections; Streptococcal Infections; Sulfonamides; Tetracycline; Vomiting

Topics: Acute Disease; Age Factors; Ampicillin; Anti-Bacterial Agents; Child, Preschool; Chloramphenicol; Colistin; Erythromycin; Haemophilus; Haemophilus Infections; Humans; Infant; Infant, Newborn; Microbial Sensitivity Tests; Otitis Media; Penicillins; Pneumococcal Infections; Staphylococcal Infections; Staphylococcus; Streptococcal Infections; Streptococcus pneumoniae; Streptococcus pyogenes; Streptomycin; Tetracycline

Topics: Adolescent; Child; Child, Preschool; Female; Furunculosis; Humans; Infant; Male; Microbial Sensitivity Tests; Minocycline; Otitis Media; Otorhinolaryngologic Diseases; Pneumococcal Infections; Staphylococcal Infections; Streptococcal Infections; Tetracycline; Tonsillitis

Topics: Administration, Oral; Cephaloridine; Child; Child, Preschool; Chloramphenicol; Dosage Forms; Erythromycin; Female; Furunculosis; Humans; Infant; Male; Microbial Sensitivity Tests; Nose Diseases; Otitis Externa; Otitis Media; Penicillin G; Sinusitis; Staphylococcus; Streptococcus pneumoniae; Streptomycin; Tetracycline; Tonsillitis

Topics: Adult; Escherichia coli; Escherichia coli Infections; Female; Humans; Otitis Media; Tetracycline

Topics: Acute Disease; Child; Cholesteatoma; Cholesterol; Chronic Disease; Drug Resistance, Microbial; Ear, Middle; Granuloma; Haemophilus Infections; Hearing Disorders; Humans; Mastoiditis; Mucous Membrane; Ossification, Heterotopic; Otitis Media; Streptococcal Infections; Tetracycline

Topics: Acute Disease; Ampicillin; Anti-Bacterial Agents; Child; Child, Preschool; Erythromycin; Humans; Infant; Otitis Media; Rifampin; Tetracycline

Topics: Antifungal Agents; Chloramphenicol; Humans; Otitis Media; Otorhinolaryngologic Diseases; Penicillin Resistance; Penicillins; Pharyngeal Diseases; Sinusitis; Streptomycin; Sulfonamides; Tetracycline

Topics: Adult; Female; Hearing Disorders; Humans; Influenza, Human; Otitis Media; Tetracycline; USSR; Vertigo; Vestibular Function Tests; Vestibule, Labyrinth

Topics: Administration, Oral; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Otitis Media; Respiratory Tract Infections; Tetracycline

Topics: Adolescent; Adult; Brain Abscess; Female; Humans; Male; Mastoiditis; Middle Aged; Otitis Media; Penicillins; Tetracycline; Tuberculosis, Meningeal

Topics: Acute Disease; Anti-Infective Agents; Chronic Disease; Hearing Disorders; Humans; Otitis Media; Penicillins; Pneumococcal Infections; Staphylococcal Infections; Streptococcal Infections; Sulfonamides; Tetracycline

Topics: Anti-Bacterial Agents; Bacillus; Bacteria; Chloramphenicol; Chlortetracycline; Chronic Disease; Colistin; Corynebacterium; Depression, Chemical; Erythromycin; Erythromycin Ethylsuccinate; Escherichia coli; Humans; Microbial Sensitivity Tests; Nasal Mucosa; Otitis Media; Oxytetracycline; Penicillin Resistance; Penicillins; Proteus; Pseudomonas aeruginosa; Staphylococcus; Streptomycin; Suppuration; Tetracycline

Topics: Adolescent; Adult; Cephaloridine; Child; Chloramphenicol; Erythromycin; Female; Furunculosis; Humans; Infections; Male; Microbial Sensitivity Tests; Middle Aged; Otitis Media; Otorhinolaryngologic Diseases; Penicillin G; Sinusitis; Staphylococcus; Streptococcus; Streptomycin; Tetracycline; Tonsillitis

Topics: Adolescent; Adult; Audiometry; Child; Drug Resistance, Microbial; Female; Furunculosis; Humans; Infant; Male; Maxillary Sinus; Microbial Sensitivity Tests; Middle Aged; Otitis Media; Otorhinolaryngologic Diseases; Palatine Tonsil; Peritonsillar Abscess; Staphylococcus; Tetracycline; Tonsillitis

Topics: Adolescent; Adult; Child; Child, Preschool; Ear Diseases; Female; Furunculosis; Humans; Laryngitis; Male; Middle Aged; Otitis Media; Otorhinolaryngologic Diseases; Pharyngitis; Pyrazoles; Sinusitis; Tetracycline; Tonsillitis

Topics: Acute Disease; Adenoidectomy; Adolescent; Age Factors; Audiometry; Child; Child, Preschool; Erythromycin; Follow-Up Studies; Humans; Infant; Otitis Media; Penicillin G; Prognosis; Seasons; Sulfonamides; Tetracycline; Tonsillectomy; Tympanic Membrane

Topics: Age Factors; Animals; Bone and Bones; Calcium; Epiphyses; Female; Male; Microscopy, Fluorescence; Otitis Media; Rats; Temporal Bone; Tetracycline; Time Factors

Topics: Brain Abscess; Cerebral Ventricles; Clostridium perfringens; Cognition Disorders; Gas Gangrene; Hemiplegia; Humans; Injections; Male; Middle Aged; Otitis Media; Penicillins; Radiography; Reflex, Stretch; Streptomycin; Tetracycline

Topics: Bronchitis; Child; Dental Enamel; Erythromycin; Humans; Iatrogenic Disease; Otitis Media; Penicillins; Pneumonia; Tetracycline

Topics: Child; Humans; Otitis Media; Penicillins; Sulfonamides; Tetracycline

Topics: Ampicillin; Anti-Bacterial Agents; Humans; Otitis Externa; Otitis Media; Otorhinolaryngologic Diseases; Penicillins; Sinusitis; Tetracycline; Tonsillitis

Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Bacterial Agents; Child; Child, Preschool; Chloramphenicol; Female; Humans; Infant; Male; Mastoiditis; Middle Aged; Otitis Media; Penicillins; Sulfonamides; Tetracycline

Topics: Asthma; Blood Protein Disorders; Bronchiectasis; Bronchitis; Child; Child, Preschool; Dermatitis, Seborrheic; Eczema; Female; gamma-Globulins; Humans; Infant; Infant, Newborn; Malabsorption Syndromes; Male; Methacycline; Otitis Media; Pneumonia; Pyelonephritis; Respiratory Tract Infections; Tetracycline; Tonsillectomy

Topics: Bronchitis; Cephalothin; Child; Child, Preschool; Chloramphenicol; Empyema; Epiglottis; Erythromycin; Escherichia coli; Haemophilus Infections; Haemophilus influenzae; Histoplasma; Humans; Infant; Klebsiella; Laryngeal Diseases; Methicillin; Mycobacterium tuberculosis; Otitis Media; Penicillins; Pneumonia; Pseudomonas; Respiratory Tract Infections; Sinusitis; Staphylococcus; Streptococcus pneumoniae; Streptococcus pyogenes; Streptomycin; Tetracycline

Topics: Ampicillin; Baths; Cross Infection; Female; Humans; Iatrogenic Disease; Infant Care; Infant, Newborn; Infant, Newborn, Diseases; Otitis Externa; Otitis Media; Penicillins; Pregnancy; Pseudomonas aeruginosa; Pseudomonas Infections; Steroids; Sweden; Tetracycline

Topics: Drug Resistance; Drug Resistance, Microbial; Drug Therapy; Humans; Otitis Media; Respiratory Tract Infections; Streptococcal Infections; Streptococcus; Tetracycline

Topics: Bacteriological Techniques; Drug Resistance; Drug Resistance, Microbial; Drug Therapy; England; Humans; Laryngitis; Otitis Media; Respiratory Tract Infections; Sinusitis; Streptococcal Infections; Tetracycline

Topics: Bronchodilator Agents; Child; Drug Therapy; Ephedrine; Ethylenediamines; Humans; Infant; Otitis Media; Penicillin G; Penicillin G Benzathine; Penicillin G Procaine; Procaine; Sulfadiazine; Sulfamerazine; Sulfamethazine; Tetracycline

Topics: Child; Drug Resistance; Drug Resistance, Microbial; Drug Therapy; Humans; Infant; Otitis Media; Pediatrics; Penicillin V; Penicillins; Respiratory Tract Infections; Tetracycline

Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Anti-Bacterial Agents; Child; Child, Preschool; Chloramphenicol; Cross Infection; England; Female; Gastroenteritis; Humans; Infant; Infant, Newborn; Male; Middle Aged; Otitis Media; Penicillins; Respiratory Tract Infections; Staphylococcal Infections; Streptomycin; Tetracycline; Urinary Tract Infections

Topics: Adolescent; Chloramphenicol; Female; Humans; Hydrocortisone; Infant, Newborn; Infant, Premature, Diseases; Nitrofurans; Otitis Media; Penicillins; Pregnancy; Sulfisoxazole; Tetracycline

Topics: Anti-Bacterial Agents; Child; Demeclocycline; Erythromycin; Ethylenediamines; Humans; Infant; Otitis Media; Penicillin G; Penicillin G Benzathine; Penicillin G Procaine; Procaine; Sulfonamides; Tetracycline

Topics: Anti-Bacterial Agents; Bacteriological Techniques; Blood; Bronchopneumonia; Cerebrospinal Fluid; Chloramphenicol; Geriatrics; Klebsiella; Klebsiella pneumoniae; Meningitis; Mortality; Otitis Media; Sepsis; Streptomycin; Tetracycline

Topics: Adolescent; Cellulitis; Child; Humans; Oleandomycin; Otitis Media; Otolaryngology; Pharyngitis; Sinusitis; Tetracycline

Topics: Anti-Bacterial Agents; Humans; Otitis Media; Postoperative Care; Protein Synthesis Inhibitors; Sinusitis; Tetracycline

Topics: Audiometry; Biomedical Research; Child; Deafness; Hearing Tests; Humans; Otitis Media; Penicillins; Tetracycline

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Chronic Disease; Humans; Influenza, Human; Laryngeal Diseases; Laryngeal Neoplasms; Otitis Media; Otolaryngology; Penicillins; Sinusitis; Streptomycin; Sulfonamides; Tetracycline; Toxicology

Topics: Acute Disease; Anti-Bacterial Agents; Child; Humans; Infant; Otitis Media; Penicillins; Pharynx; Sulfanilamide; Sulfanilamides; Sulfonamides; Tetracycline; Tissue Culture Techniques

Topics: Anti-Bacterial Agents; Bacteria; Chloramphenicol; Chlortetracycline; Drug Resistance; Drug Resistance, Microbial; Humans; Otitis Media; Penicillins; Streptomycin; Sulfisoxazole; Tetracycline; Tympanoplasty

Topics: Anti-Bacterial Agents; Humans; Meningitis; Otitis Media; Protein Synthesis Inhibitors; Tetracycline

Topics: Anti-Bacterial Agents; Humans; Novobiocin; Otitis Media; Protein Synthesis Inhibitors; Tetracycline