tetracycline and Osteomyelitis

Topics: Anti-Bacterial Agents; Clindamycin; Humans; Methicillin Resistance; Osteomyelitis; Staphylococcal Infections; Staphylococcus aureus; Tetracycline; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin

Topics: Ampicillin; Anti-Bacterial Agents; Bacterial Infections; Biliary Tract Diseases; Carbenicillin; Cephalosporins; Chloramphenicol; Colistin; Endocarditis, Subacute Bacterial; Gentamicins; Humans; Meningitis; Osteomyelitis; Oxacillin; Sepsis; Tetracycline; Urinary Tract Infections

Topics: Alkylation; Bone and Bones; Erythromycin; Escherichia coli; Klebsiella; Lincomycin; Osteomyelitis; Proteus; Pseudomonas aeruginosa; Ribosomes; Salmonella paratyphi A; Staphylococcal Infections; Staphylococcus; Streptococcus; Streptococcus pneumoniae; Streptomyces; Tetracycline

Topics: Child; Chronic Disease; Clinical Trials as Topic; Cloxacillin; Humans; Osteomyelitis; Staphylococcal Infections; Tetracycline; Uganda

Topics: Adolescent; Adult; Aged; Ampicillin; Aspartate Aminotransferases; Child; Clinical Trials as Topic; Digestive System; Erythromycin; Female; Haemophilus Infections; Haemophilus influenzae; Humans; Lincomycin; Male; Methicillin; Microbial Sensitivity Tests; Middle Aged; Osteomyelitis; Penicillin Resistance; Penicillins; Respiratory Tract Infections; Sepsis; Skin Diseases, Infectious; Staphylococcal Infections; Streptococcus; Streptococcus pyogenes; Tetracycline; Time Factors

Osteomyelitis due to Coxiella burnetii infection is a rare condition in adults. We report the case of a healthy young man presenting with subacute osteomyelitis of the left cheek bone, evolving gradually after an episode of acute febrile illness. Histological evaluation confirmed subacute granulomatous inflammation. Despite antibody titres not reaching the standard cut-off for chronic Q fever (phase I IgG 1/160, phase II IgG 1/2560), osteomyelitis was radiologically and histologically confirmed. A 6-month course of doxycycline/hydroxychloroquine brought clinical and radiological cure while various conventional antibiotic treatments had failed to improve the clinical condition. Currently, at 6-month follow-up, no relapse has occurred and antibody titres have declined. A shorter course of doxycycline/hydroxychloroquine than that used for chronic Q fever osteomyelitis may be sufficient to treat subacute Q fever osteomyelitis in some cases.

Topics: Anti-Bacterial Agents; Antibodies, Bacterial; Doxycycline; Granuloma; Humans; Hydroxychloroquine; Magnetic Resonance Imaging; Male; Osteomyelitis; Q Fever; Tetracycline; Young Adult; Zygoma

Enterococcus hirae infections are reported to cause growth depression, encephalomalacia, endocarditis, and septicemia in chickens. This report describes osteomyelitis in the proximal femur of a 3-week-old broiler chicken that also suffered from valvular endocarditis and liver necrosis. Histologically, clusters of gram-positive coccoid bacteria were found in many organs, including bone lesions. In tissues from 5 of 6 examined chickens from the same flock, E hirae was isolated in large numbers. To the authors' knowledge, this is the first report of spontaneous bacterial osteomyelitis where E hirae was cultured from bone and where coccoid bacteria consistent with Enterococcus spp were simultaneously demonstrated within bone lesions.

Topics: Ampicillin; Animals; Anti-Bacterial Agents; Bacterial Typing Techniques; Chickens; DNA, Bacterial; DNA, Ribosomal; Endocarditis, Bacterial; Enterococcus; Gram-Positive Bacterial Infections; Norway; Osteomyelitis; Poultry Diseases; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Tetracycline

Topics: Anti-Bacterial Agents; Chronic Disease; Debridement; Female; Fluorescent Dyes; Humans; Mandible; Mandibular Diseases; Middle Aged; Necrosis; Osteomyelitis; Staining and Labeling; Tetracycline; Ultraviolet Rays

The authors have found that several months of preoperative tetracycline administration will label living bone so that it fluoresces under a blacklight during surgery. This allows intraoperative differentiation of viable bone from necrotic sequestra, which require removal in the treatment of chronic bone infection.

Topics: Chronic Disease; Debridement; Fluorescence; Humans; Indicators and Reagents; Osteomyelitis; Osteonecrosis; Preoperative Care; Sensitivity and Specificity; Tetracycline

Mucosal changes have been well described in chronic sinusitis, yet little is known about the underlying bone, despite clinical and experimental evidence suggesting that bone may be involved in chronic sinusitis. Techniques of undecalcified bone analysis were used for detailed histologic examination of ethmoid bone in chronic sinusitis compared with controls. Bone synthesis, resorption, and inflammatory cell presence were specifically assessed. Additionally, histomorphometry techniques were used to determine ethmoid bone physiology in individuals undergoing surgery for chronic sinusitis. Overall, individuals undergoing surgery for chronic sinusitis were found to have evidence of marked acceleration in bone physiology with histologic changes including new bone formation, fibrosis, and presence of inflammatory cells. These findings are compared with osteomyelitis in long bone and the jaw. The suggestion that underlying bone may serve as a catalyst for chronic sinusitis is supported and implications for therapy are discussed.

Topics: Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Bone Remodeling; Bone Resorption; Chronic Disease; Coloring Agents; Demeclocycline; Edema; Endoscopy; Ethmoid Bone; Ethmoid Sinusitis; Female; Fibrosis; Humans; Male; Mandibular Diseases; Mucous Membrane; Osteitis; Osteogenesis; Osteomyelitis; Prospective Studies; Rhinitis; Single-Blind Method; Tetracycline; Turbinates

Mycoplasma species are recognized as important pathogens in patients with hypogammaglobulinemia. In this article we describe, for the first time, a patient with hypogammaglobulinemia who developed osteomyelitis of the hip caused by Ureaplasma urealyticum. This article emphasizes the need for considering infection with Mycoplasma species in patients with antibody deficiency.

Topics: Adult; Agammaglobulinemia; Hip; Humans; Male; Mycoplasma Infections; Osteomyelitis; Radiography; Streptomycin; Tetracycline; Ureaplasma

Two young males with acne fulminans (AF) are described. In addition to severe skin lesions, they had musculoskeletal symptoms including bacteriologically negative osteolytic lesions in the clavicles. Both patients received antibiotics for suspected septic infections. The response was unsatisfactory in both patients, and combination treatment with prednisolone was started. A favourable response was observed, and a relapse occurring in the first patient was controlled by steroids alone. The possible pathomechanism of bone lesions in AF is discussed.

Topics: Acne Vulgaris; Adolescent; Drug Therapy, Combination; Humans; Male; Osteomyelitis; Prednisolone; Radionuclide Imaging; Recurrence; Tetracycline

Dr. Miller's discussion of the diagnosis and management of soft tissue infections is probably one of the most important topics in this issue. We are all faced with the potential for relatively minor infections becoming serious problems. Having a sound understanding of the infectious process and treatment regimens is extremely important in our general practices. Few things can make a patient as unhappy or destroy good surgical results as quickly and easily as an infection. I recommend reading the articles suggested by Dr. Miller and add that I believe that if the infection has not responded as quickly to therapy as is expected, an infectious disease consultation should be requested.

Topics: Adult; Bone Screws; Cefazolin; Dicloxacillin; Foot Dermatoses; Humans; Male; Nails, Ingrown; Osteomyelitis; Staphylococcal Skin Infections; Staphylococcus aureus; Tetracycline; Toe Joint; Toes

A 19-year-old man incurred a closed femoral fracture complicated by hematogenous dissemination of Brucella osteomyelitis. Repeated limited incision and drainage were ineffective in eradicating infection. Wide debridement, delayed wound closure, and vigorous antimicrobial therapy with streptomycin and tetracycline, along with cephalosporin for secondary staphylococcal infection, were necessary measures before the infection was eradicated. A constant awareness of brucella musculoskeletal infection is advisable when caring for patients frequently exposed to all kinds of livestock, including domesticated and wild animals.

Topics: Adult; Brucella abortus; Brucellosis; Cephalosporins; Combined Modality Therapy; Debridement; Drainage; Femoral Fractures; Fractures, Closed; Humans; Male; Osteomyelitis; Staphylococcal Infections; Streptomycin; Tetracycline; Time Factors; Wound Infection

Combination of rifampicin with trimethoprim, erythromycin, tetracycline or fusidic acid have some desirable features in the treatment of difficult infections. They are active against a very wide range of possible pathogens. Resistance to rifampicin is rare. Such combinations may be bactericidal and may be usefully synergistic. They may prevent or delay the emergence of bacterial resistant seen when some single agents are used. They can be used in patients with penicillin hypersensitivity. A series of life-threatening infections has been treated with rifampicin-containing combinations. The infections included endocarditis, meningitis, pneumonia, Legionnaire's disease, and head and neck sepsis. A major reason for the choice of drug was often penicillin hypersensitivity. A second reason was the presumption (mostly subsequently confirmed) that streptococci and/or staphylococci were implicated. The clinical outcome of these infections was generally satisfactory, with few side effects and little evidence of the emergence of antibiotic resistance.

Topics: Adolescent; Adult; Aged; Bacterial Infections; Drug Therapy, Combination; Erythromycin; Female; Fusidic Acid; Humans; Infant; Legionnaires' Disease; Male; Meningitis; Middle Aged; Osteomyelitis; Rifampin; Sepsis; Skin Diseases, Infectious; Staphylococcal Infections; Tetracycline; Trimethoprim

Topics: Adult; Brucella; Brucellosis; Femur; Humans; Male; Osteomyelitis; Radiography; Tetracycline

Topics: Adolescent; Adult; Aged; Female; Humans; Intraoperative Care; Male; Middle Aged; Osteomyelitis; Penicillins; Staphylococcal Infections; Suction; Tetracycline

Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Arthritis, Infectious; Cattle; Cattle Diseases; Cystitis; Diarrhea; Escherichia coli Infections; Female; Foot Diseases; Fusobacterium Infections; Liver Abscess; Mastitis, Bovine; Meningitis; Osteomyelitis; Pasteurella Infections; Pneumonia; Respiratory Tract Infections; Salmonella Infections, Animal; Sheep; Sheep Diseases; Streptococcal Infections; Sulfonamides; Tetracycline; Uterine Diseases

Two boys aged up to 2 weeks suffered from enterobacter-sepsis. In both cases osteomyelitis developed in spite of treatment with Gentamycin or Gentamycin combined with Chepazolin. Both children were, taking accont of the risks, then treated with Chloramphenicol (100 mg/kg body weight/24 hours) and the first patient also, for a short time, with tetracyclin. In the second patient we saw a marrow depression dependent on Chloramphenicol and its dosage which disappeared rapidly, when the drug was withheld.

Topics: Chloramphenicol; Enterobacteriaceae Infections; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Osteomyelitis; Sepsis; Tetracycline

Topics: Aged; Ampicillin; Back Pain; Cloxacillin; Erythromycin; Humans; Immobilization; Lumbar Vertebrae; Male; Middle Aged; Osteomyelitis; Postoperative Complications; Radiography; Spinal Diseases; Streptomycin; Tetracycline; Thoracic Vertebrae; Urinary Tract Infections; Urologic Diseases

Topics: Animals; Brucella; Brucellosis; Dog Diseases; Dogs; Intervertebral Disc; Lumbar Vertebrae; Male; Osteomyelitis; Radiography; Sacrum; Spondylitis; Tetracycline; Thoracic Vertebrae

Topics: Abscess; Ampicillin; Calcaneus; Child; Child, Preschool; Chloramphenicol; Cloxacillin; Curettage; Erythromycin; Female; Fusidic Acid; Humans; Male; Osteomyelitis; Penicillins; Radiography; Staphylococcal Infections; Streptococcal Infections; Talus; Tetracycline

Topics: Anti-Bacterial Agents; Antifungal Agents; Candidiasis, Oral; Endocarditis, Bacterial; Erythromycin; General Practice, Dental; Humans; Immunosuppression Therapy; Injections, Intramuscular; Jaw Fractures; Mouth Diseases; Osteomyelitis; Penicillins; Periapical Abscess; Pericoronitis; Radiotherapy; Tetracycline

Topics: Adult; Drug Resistance, Microbial; Erythromycin; Humans; Male; Minocycline; Osteomyelitis; Penicillin Resistance; Staphylococcal Infections; Tetracycline

Topics: Arthritis, Infectious; Cephalosporins; Cloxacillin; Dicloxacillin; Germany, West; Humans; Kanamycin; Lincomycin; Orthopedics; Osteomyelitis; Oxacillin; Penicillin G; Penicillin Resistance; Penicillin V; Pseudomonas aeruginosa; Pseudomonas Infections; Staphylococcal Infections; Surgical Wound Infection; Tetracycline

Topics: Actinobacillus Infections; Ampicillin; Bacteria; Child; Child, Preschool; Chloramphenicol; Empyema; Female; Haemophilus Infections; Humans; Infant; Male; Meningitis, Haemophilus; Microbial Sensitivity Tests; Osteomyelitis; Penicillin Resistance; Peritonitis; Tetracycline

Topics: Anti-Bacterial Agents; Cellulitis; Chloramphenicol; Diathermy; Erythromycin; Humans; Jaw Diseases; Mouth Diseases; Osteitis; Osteomyelitis; Penicillin Resistance; Penicillins; Sulfonamides; Tetracycline

Topics: Abscess; Adult; Amputation Stumps; Amputation, Surgical; Chloramphenicol; Humans; Male; Melioidosis; Military Medicine; Novobiocin; Osteomyelitis; Pseudomonas; Pseudomonas Infections; Sepsis; Sulfisoxazole; Surgical Wound Infection; Tetracycline; Wound Infection

Topics: Adolescent; Adult; Aged; Bone and Bones; Bone Diseases; Drug Combinations; Female; Fingers; Hand; Humans; Injections; Male; Middle Aged; Morpholines; Oleandomycin; Osteomyelitis; Paronychia; Suppuration; Tetracycline

Topics: Abscess; Acute Disease; Bacteria; Cellulitis; Chloramphenicol; Erythromycin; Humans; Mouth Diseases; Osteomyelitis; Penicillin Resistance; Penicillins; Seasons; Staphylococcus; Streptomycin; Suppuration; Tetracycline; Tooth Diseases

Topics: Anti-Bacterial Agents; Erythromycin Ethylsuccinate; Fractures, Bone; Humans; Injections, Intra-Arterial; Joint Dislocations; Kanamycin; Oleandomycin; Osteomyelitis; Streptomycin; Suppuration; Tetracycline

Topics: Ampicillin; Anti-Bacterial Agents; Empyema; Erysipelas; Erythromycin; Humans; Lymphadenitis; Osteomyelitis; Oxacillin; Penicillin G; Penicillin V; Salivary Gland Diseases; Streptomycin; Tetracycline

Topics: Acute Disease; Animals; Bites and Stings; Bone Regeneration; Carbenicillin; Child; Dogs; Female; Gentamicins; Humans; Humerus; Methicillin; Osteomyelitis; Pseudomonas Infections; Radiography; Tetracycline

Topics: Humans; Lincomycin; Osteomyelitis; Staphylococcal Infections; Surgical Wound Infection; Tetracycline; Wound Infection

Topics: Anti-Bacterial Agents; Burns; Cephalosporins; Chloramphenicol; Dihydrostreptomycin Sulfate; Empyema; Gentamicins; Humans; Infections; Osteomyelitis; Penicillin Resistance; Penicillins; Sepsis; Streptomycin; Surgical Wound Infection; Tetracycline

Topics: Adolescent; Adult; Cephalosporins; Chloramphenicol; Chronic Disease; Culture Media; Enterococcus faecalis; Erythromycin; Female; Femoral Fractures; Femur Head; Humans; Hypertonic Solutions; Kanamycin; L Forms; Male; Microbial Sensitivity Tests; Middle Aged; Necrosis; Osteomyelitis; Penicillins; Polymyxins; Proteus; Radiography; Staphylococcal Infections; Staphylococcus; Tetracycline; Vancomycin

Topics: Acute Disease; Child; Child, Preschool; Cloxacillin; Erythromycin; Fusidic Acid; Humans; Osteomyelitis; Penicillin Resistance; Penicillins; Staphylococcal Infections; Tetracycline

Topics: Anti-Bacterial Agents; Cellulitis; Cephalosporins; Erythromycin; Humans; Jaw Diseases; Microbial Sensitivity Tests; Mouth Diseases; Osteitis; Osteomyelitis; Penicillins; Tetracycline

Topics: Antisepsis; Carrier State; Cross Infection; Disease Outbreaks; Epidemiologic Methods; Female; Hand; Hexachlorophene; Hospital Departments; Humans; Infant Care; Infant, Newborn; Infant, Newborn, Diseases; Male; Meningitis; Nursing Staff, Hospital; Osteomyelitis; Proteus; Proteus Infections; Rectum; Sepsis; Tetracycline; Umbilical Cord; Vagina

Topics: Adult; Anti-Bacterial Agents; Chemotherapy, Cancer, Regional Perfusion; Chloramphenicol; Chlortetracycline; Female; Femur; Humans; Humerus; Kanamycin; Male; Metatarsus; Methicillin; Middle Aged; Neomycin; Osteomyelitis; Oxytetracycline; Protamines; Streptomycin; Tetracycline; Tibia

Topics: Acute Disease; Age Factors; Anti-Bacterial Agents; Child; Child, Preschool; Female; Femur; Haemophilus Infections; Humans; Humerus; Infant; Infant, Newborn; Male; Osteomyelitis; Penicillin Resistance; Penicillins; Proteus Infections; Radiography; Radius; Salmonella Infections; Seasons; Sepsis; Splints; Staphylococcal Infections; Streptococcal Infections; Tetracycline; Tibia; Ulna

Topics: Adult; Drug Resistance, Microbial; Erythromycin; Humans; Lincomycin; Male; Microbial Sensitivity Tests; Osteomyelitis; Pneumococcal Infections; Tetracycline

Topics: Abdomen; Adolescent; Adult; Aged; Anti-Bacterial Agents; Bronchiectasis; Child; Cholecystitis; Female; Humans; Injections, Intravenous; Lung Abscess; Lung Diseases; Male; Middle Aged; Morpholines; Myocarditis; Oleandomycin; Osteomyelitis; Pancreatitis; Peritonitis; Pneumonia; Tetracycline; Thoracic Surgery; Thorax

Topics: Acute Disease; Adolescent; Adult; Animals; Child; Child, Preschool; Chronic Disease; Dogs; Female; Humans; Infant; Infant, Newborn; Injections; Male; Middle Aged; Osteomyelitis; Rabbits; Tetracycline

Topics: Anesthetics, Local; Finger Joint; Humans; Joint Diseases; Oleandomycin; Osteomyelitis; Paronychia; Tetracycline

Topics: Acute Disease; Adult; Aged; Brucellosis; Chronic Disease; Female; Humans; Male; Middle Aged; Osteomyelitis; Radiography; Staphylococcal Infections; Tetracycline; Typhoid Fever

Topics: Adult; Anti-Bacterial Agents; Chronic Disease; Drug Synergism; Humans; Male; Middle Aged; Osteomyelitis; Peptide Hydrolases; Tetracycline

Topics: Chronic Disease; Fluorescent Antibody Technique; Humans; Osteomyelitis; Staphylococcal Infections; Suppuration; Tetracycline

Topics: Abscess; Adolescent; Adult; Bile; Child; Escherichia coli; Female; Humans; Inflammation; Male; Microbial Sensitivity Tests; Middle Aged; Osteomyelitis; Skin Diseases; Staphylococcus; Surgical Wound Infection; Tetracycline; Wound Infection

Topics: Adult; Aged; Animals; Bites and Stings; Child; Child, Preschool; Chloramphenicol; Disease Reservoirs; Erythromycin; Female; Humans; Lung Diseases; Male; Middle Aged; Osteomyelitis; Pasteurella Infections; Penicillin G; Penicillin V; Penicillins; Tetracycline; Ulcer; Wound Infection; Zoonoses

Topics: Adolescent; Adult; Aged; Cysts; Female; Humans; Infection Control; Infections; Jaw Diseases; Male; Middle Aged; Mouth Diseases; Osteitis; Osteomyelitis; Radiation Injuries; Salivary Gland Diseases; Tetracycline; Tonsillitis

Topics: Angiography; Chronic Disease; Humans; Methods; Osteomyelitis; Tetracycline; Therapeutic Irrigation

Topics: Adolescent; Adult; Child; Child, Preschool; Chronic Disease; Female; Fluorometry; Humans; Male; Methods; Middle Aged; Myelography; Osteomyelitis; Suppuration; Tetracycline; Therapeutic Irrigation

Topics: Adult; Aged; Arthritis; Bacteria; Child; Drug Synergism; Drug Tolerance; Female; Humans; Male; Middle Aged; Osteomyelitis; Penicillin V; Phlebitis; Respiratory Tract Infections; Staphylococcus; Tetracycline; Varicose Ulcer

Topics: Aeromonas; Child; Female; Humans; Leukemia, Myeloid, Acute; Mercaptopurine; Osteomyelitis; Penicillin Resistance; Penicillins; Sepsis; Tetracycline

Topics: Animals; Bone and Bones; Bone Regeneration; Fluorescence; Fractures, Bone; Male; Osteomyelitis; Rabbits; Tetracycline

Topics: Adult; Ascorbic Acid; Chronic Disease; Escherichia coli Infections; Female; Humans; Infections; Lung Diseases; Male; Middle Aged; Osteomyelitis; Peritonitis; Pleural Diseases; Pneumonia; Staphylococcal Infections; Streptococcal Infections; Suppuration; Surgical Wound Infection; Tetracycline; Thiamine

Topics: Adult; Enteral Nutrition; Fracture Fixation; Humans; Male; Mandibular Fractures; Maxillary Fractures; Maxillofacial Injuries; Metals; Neck Injuries; Necrosis; Osteomyelitis; Radiography; Skin Transplantation; Spinal Injuries; Splints; Stainless Steel; Surgery, Plastic; Tetracycline; Tracheotomy

Topics: Adolescent; Child; Chloramphenicol; Female; Humans; Male; Osteomyelitis; Surgical Wound Infection; Tetracycline

Topics: Child; Chloramphenicol; Femur; Humans; Male; Osteomyelitis; Perfusion; Tetracycline

Topics: Anti-Bacterial Agents; Humans; Lymphangitis; Oleandomycin; Osteomyelitis; Peritonitis; Pneumonia; Postoperative Complications; Staphylococcal Infections; Tetracycline; Wound Infection

Topics: Anti-Bacterial Agents; Child; Dietary Proteins; Drug Therapy; Mandible; Osteomyelitis; Penicillins; Radiography, Dental; Streptomycin; Tetracycline; Tooth Extraction; Vitamins

Topics: Amputation, Surgical; Anti-Bacterial Agents; Bone Marrow; Bone Transplantation; Drug Therapy; Fracture Fixation; Humans; Leg Injuries; Oleandomycin; Orthopedics; Osteomyelitis; Surgical Procedures, Operative; Tetracycline; Thigh

Topics: Adolescent; Anti-Bacterial Agents; Bacteriological Techniques; Child; Chloramphenicol; Drug Resistance; Drug Resistance, Microbial; Endocarditis; Endocarditis, Bacterial; Erythromycin; Fever; Infant; Infant, Newborn; Leukocyte Count; Meningitis; Methicillin; Middle Aged; Mortality; Osteomyelitis; Penicillins; Sepsis; Staphylococcal Infections; Streptomycin; Tetracycline

Topics: Anti-Bacterial Agents; Child; Chloramphenicol; Erythromycin; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Osteomyelitis; Penicillins; Radiography; Tetracycline

Topics: Adolescent; Anti-Bacterial Agents; Black People; Child; Infant; Infant, Newborn; Osteomyelitis; Penicillins; Staphylococcal Infections; Sulfanilamide; Sulfanilamides; Sulfonamides; Surgical Procedures, Operative; Tetracycline

Topics: Abscess; Air Microbiology; Antisepsis; Bacteriological Techniques; Bacteriophage Typing; Burns; Chloramphenicol; Drug Resistance; Drug Resistance, Microbial; Empyema; Enteritis; Epidemiology; Osteomyelitis; Penicillins; Pneumonia; Postoperative Complications; Pressure Ulcer; Pyelonephritis; Sepsis; Staphylococcal Infections; Staphylococcus; Staphylococcus Phages; Tetracycline; Toxicology; Wound Infection

Topics: Adolescent; Animals; Anti-Bacterial Agents; Cellulitis; Child; Endocarditis; Erythromycin; Female; Furunculosis; Fusidic Acid; Geriatrics; Humans; Infant; Meningitis; Osteomyelitis; Penicillins; Pneumonia; Pregnancy; Puerperal Infection; Pyelonephritis; Staphylococcal Infections; Streptomycin; Sulfonamides; Tetracycline; Wound Infection

Topics: Apnea; Colistin; Dexamethasone; Escherichia coli Infections; Femoral Fractures; Fractures, Spontaneous; Hydrocortisone; Injections; Injections, Intramuscular; Osteomyelitis; Spinal Injuries; Tetracycline; Toxicology

Preliminary results suggest that the antibiotic lincomycin (a product of Streptomyces lincolnensis var. lincolnensis) possesses certain valuable properties which include good in vitro activity against many strains of hospital staphylococci resistant to many other antibiotics. During a study of this agent, a selected series of severe staphylococcal infections due to resistant organisms were treated with lincomycin, with encouraging responses. Favourable results were also noted in seven cases of osteomyelitis. Lincomycin may be administered by the oral or parenteral routes to adults and infants and satisfactory serum blood levels obtained. So far as the authors' limited experience enables them to conclude, and at the dose range tested, this antibiotic promises to be one of low toxicity.

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Bacteriology; Biomedical Research; Canada; Chloramphenicol; Drug Resistance; Drug Resistance, Microbial; Drug Therapy; Erythromycin; Geriatrics; Gram-Positive Cocci; Humans; Infant; Lincomycin; Methicillin; Novobiocin; Osteomyelitis; Penicillins; Research; Staphylococcal Infections; Staphylococcus; Streptomycin; Tetracycline; Toxicology

Topics: Adolescent; Chloramphenicol; Frontal Bone; Frontal Sinus; Humans; Methicillin; Osteomyelitis; Plastics; Radiography; Sinusitis; Skull; Staphylococcal Infections; Streptococcal Infections; Streptomycin; Sulfonamides; Surgery, Plastic; Surgical Procedures, Operative; Tetracycline

Topics: Humans; Osteomyelitis; Protein Synthesis Inhibitors; Radiography, Thoracic; Ribs; Tetracycline

Topics: Abscess; Arthritis; Child; Chloramphenicol; Diagnosis, Differential; Drainage; Erythromycin; Humans; Infant; Joint Diseases; Novobiocin; Osteomyelitis; Oxytetracycline; Penicillins; Sepsis; Staphylococcal Infections; Streptococcal Infections; Suppuration; Surgical Procedures, Operative; Tetracycline

Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Betamethasone; Child; Dexamethasone; Humans; Infant; Osteomyelitis; Smallpox; Tetracycline

Topics: Anti-Bacterial Agents; Fractures, Bone; Gangrene; Hospitals, General; Injections, Intravenous; Orthopedics; Osteomyelitis; Rolitetracycline; Tetracycline; Toxicology; Ulcer; Wounds and Injuries

Topics: Anti-Bacterial Agents; Chloramphenicol; Osteomyelitis; Staphylococcal Infections; Tetracycline

Topics: Abscess; Anti-Bacterial Agents; Appendicitis; Bursitis; Carbuncle; Cellulitis; Empyema; Geriatrics; Humans; Infant; Lymphadenitis; Lymphangitis; Oleandomycin; Osteomyelitis; Paronychia; Parotitis; Peritonitis; Suppuration; Surgical Wound Infection; Tetracycline

Topics: Anti-Bacterial Agents; Chloramphenicol; Cross Infection; Drug Resistance; Drug Resistance, Microbial; Erythromycin; Kanamycin; Oleandomycin; Osteomyelitis; Penicillin G; Staphylococcal Infections; Streptomycin; Tetracycline; Wound Infection

Topics: Anti-Bacterial Agents; Bronchiectasis; Cholangitis; Coombs Test; Drug Hypersensitivity; Empyema; Endocarditis; Endocarditis, Bacterial; Hemagglutination; Humans; Osteomyelitis; Penicillins; Precipitin Tests; Pyelonephritis; Sepsis; Streptomycin; Tetracycline

Topics: Anti-Bacterial Agents; Fluorescent Antibody Technique; Humans; Osteomyelitis; Staphylococcal Infections; Staphylococcus; Tetracycline

Topics: Anti-Bacterial Agents; Child; Infant; Osteomyelitis; Penicillins; Protein Synthesis Inhibitors; Tetracycline

Topics: Humans; Novobiocin; Osteomyelitis; Staphylococcal Infections; Tetracycline

Topics: Anti-Bacterial Agents; Bone and Bones; Humans; Osteomyelitis; Protein Synthesis Inhibitors; Tetracycline

Topics: Anti-Bacterial Agents; Chloramphenicol; Osteomyelitis; Plastic Surgery Procedures; Protein Synthesis Inhibitors; Skin Transplantation; Surgery, Plastic; Tetracycline

Topics: Anti-Bacterial Agents; Chlortetracycline; Ointments; Osteomyelitis; Protein Synthesis Inhibitors; Tetracycline

Topics: Anti-Bacterial Agents; Humans; Oleandomycin; Osteomyelitis; Respiratory System; Respiratory Tract Infections; Tetracycline; Urinary Tract; Urinary Tract Infections

Topics: Anti-Bacterial Agents; Bacteremia; Humans; Osteomyelitis; Sepsis; Tetracycline

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Dermatologic Agents; Humans; Osteomyelitis; Protein Synthesis Inhibitors; Tetracycline