tetracycline and Nail-Diseases

Two cases of yellow nail syndrome (a triad of yellow dystrophic nails, chronic lymphedema and pleural effusion) are described which demonstrate long-term control of recurrent pleural effusions by tetracycline pleurodesis. Neither patient developed problems as a result of the procedure enabling us to conclude that tetracycline pleurodesis is effective in managing reaccumulating pleural fluid in yellow nail syndrome and may avoid loss of lung function due to pleural peel.

Topics: Aged; Chronic Disease; Female; Follow-Up Studies; Humans; Lymphedema; Male; Middle Aged; Nail Diseases; Pleural Effusion; Pleurodesis; Syndrome; Tetracycline

Topics: Animals; Anti-Bacterial Agents; Atrophy; Dog Diseases; Dogs; Fatty Acids, Unsaturated; Female; Hoof and Claw; Nail Diseases; Niacinamide; Tetracycline; Treatment Outcome; Vitamin B Complex

Topics: Aged; Combined Modality Therapy; Diabetes Mellitus, Type 2; Disease Progression; Female; Finland; Follow-Up Studies; Humans; Hypertension; Nail Diseases; Pleural Effusion; Pleurodesis; Radiography, Thoracic; Risk Assessment; Severity of Illness Index; Tetracycline

We have studied 15 patients with photo-onycholysis induced by tetracyclines, psoralens, or fluoroquinolones. Three distinct clinical subtypes of onycholysis were seen. Type I showed a half-moon-shaped separation that was concave distally. Type II had a circular notch opened distally and shaped as if the distal nail plate had acted as a convex lens. In type III the changes were located in the central part of the nail bed with no connection to the margins. Ultraviolet (UV) irradiation of normal fingernails with various wavelengths showed that 3% to 20% of the irradiation could penetrate the nail. The different patterns of photodamage might be caused by the nail acting as a lens. Less protection by lack of melanin and absence of sebum and stratum granulosum may favor penetration of UV irradiation and explain why the skin was not always affected.

Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Child; Doxycycline; Drug Eruptions; Female; Humans; Male; Middle Aged; Nail Diseases; Nails; Norfloxacin; Ofloxacin; Oxazines; Pefloxacin; Photosensitivity Disorders; PUVA Therapy; Tetracycline; Trioxsalen; Ultraviolet Rays

A case of monosymptomatic photo-onycholysis due to tetracycline-hydrochloride is reported. A 40-year-old woman with rosacea had been treated with tetracycline-hydrochloride (Achromycin) 250 mg daily for 3 years. In the summer period after one month of intensive sun exposure she developed painful bullae under the nails.

Topics: Adult; Female; Humans; Nail Diseases; Photosensitivity Disorders; Rosacea; Tetracycline

Yellow lunulae with yellow fluorescence under Wood's lamp examination developed in a patient treated with a high-dose tetracycline hydrochloride regimen for cystic acne after one month of therapy. The clinical findings in other causes of yellow nail pigmentation are reviewed. The Wood's lamp examination is useful in distinguishing tetracycline-induced yellow nails from other causes of yellow nail pigmentation and may be helpful in determining patient compliance with tetracycline hydrochloride regimens of 1 g or more daily.

Topics: Acne Vulgaris; Adult; Dose-Response Relationship, Drug; Humans; Male; Nail Diseases; Patient Compliance; Pigmentation Disorders; Tetracycline

A case of onycholysis secondary to the ingestion of tetracycline hydrochloride is reported. The patient was not photosensitive, and the nails returned to normal after withdrawal of the causative drug.

Topics: Adult; Humans; Male; Nail Diseases; Syphilis, Cardiovascular; Tetracycline

Photo-onycholysis is a rare complication of tetracycline therapy. Its occurrence is probably greater than the few reported cases indicate. It is hoped that this case report will alert physicians to its occurrence.

Topics: Adolescent; Drug Hypersensitivity; Female; Humans; Nail Diseases; Photosensitivity Disorders; Tetracycline