tetracycline and Myocarditis

The authors describe the case of a fifty-nine-year-old white man, previously in good health, who initiated his present illness with acute episode of enterocolitis characterized by mild fever and, in the next eight hours, twenty-four episodes of watery diarrhea, nausea and vomiting, as well as generalized sweating and severe weakness secondary to hypovolemia and electrolyte disorder. These complications were corrected in seventy-two hours in the intensive care unit. Two days later, when the patient was stable hemodynamically, under cardiac monitoring and with normal laboratory studies including serum electrolytes, he developed electrocardiographic changes characterized by trifascicular block (prolonged P-R interval, complete right bundle branch block [CRBBB] and left posterior hemiblock [LPH]) with a cardiac rate of thirty beats per minute, for which a temporary pacemaker was inserted. Endomyocardial biopsy showed histopathologic signs of myocarditis and the immunologic study of the cardiac tissue revealed positive polymerize chain reaction (PCR+) with the presence of antitoxine choleric antibodies (AcTCA). After three weeks, the same conduction disturbances remained, for which a permanent pacemaker was inserted. On top of intravenous fluid replacement and electrolyte supplements, the patient was managed with tetracycline 2 g a day for one week and sulfamethoxazole-trimethoprim 800/160 mg a day for two weeks. The purpose of this study is to present a rare and very well-documented myocarditis by cholera in a patient with enteric disease, in whom several cardiac complications occurred.

Topics: Anti-Bacterial Agents; Antibodies, Bacterial; Bradycardia; Bundle-Branch Block; Cholera; Diarrhea; Electrocardiography; Enterocolitis; Humans; Male; Middle Aged; Myocarditis; Nausea; Pacemaker, Artificial; Polymerase Chain Reaction; Sweating; Tetracycline; Trimethoprim, Sulfamethoxazole Drug Combination; Vibrio cholerae; Vomiting

Topics: Boutonneuse Fever; Humans; Male; Middle Aged; Myocarditis; Tetracycline

Topics: Female; Humans; Middle Aged; Myocarditis; Psittacosis; Tetracycline

Analysis of 302 side effects of antibiotic theraphy is presented. The side effects were studied comparatively as dependent on the antibiotic group. Dependence of the toxic and toxicoallergic reactions to the antibiotics on the antibiotic blood levels were noted. Previous sensitization resulted in more frequent and earlier side effects. The analysis and clinical observations showed that antibiotic therapy should take into account the results of the laboratory tests, i.e. examination of the kidney functional state, antibiotic levels in the blood and urine, tolerance of the drug by the patient.

Topics: Acute Disease; Adolescent; Adult; Aged; Aminoglycosides; Anaphylaxis; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Hypersensitivity; Erythromycin; Female; Humans; Hypersensitivity, Delayed; Kidney; Leukocytes; Male; Middle Aged; Myocarditis; Oleandomycin; Penicillins; Skin; Streptomycin; Tetracycline; Urinary Tract

Topics: Adolescent; Adult; Ampicillin; Anemia; Arthritis, Infectious; Arthritis, Reactive; Endocarditis, Bacterial; Female; Gonorrhea; Hepatitis; Humans; Male; Meningitis; Menstruation; Myocarditis; Neisseria gonorrhoeae; Penicillin G Procaine; Penicillin V; Pericarditis; Pregnancy; Pregnancy Complications, Infectious; Pyuria; Sepsis; Skin Diseases; Tetracycline

Topics: Adolescent; Adult; Age Factors; Aged; Arthritis; Child; Child, Preschool; Diarrhea; Diet Therapy; Enteritis; Erythema; Erythema Nodosum; Feces; Female; Gastroenteritis; Humans; Infant; Infant, Newborn; Male; Middle Aged; Myocarditis; Pasteurella; Pasteurella Infections; Prognosis; Sex Factors; Sulfonamides; Sweden; Tetracycline

Topics: Adolescent; Adult; Animals; Antigens, Viral; Child; Digitalis Glycosides; Female; Fetal Diseases; Heart Defects, Congenital; Humans; Hypertension, Pulmonary; Male; Mice; Middle Aged; Myocarditis; Pregnancy; Tetracycline; Virus Diseases; Virus Replication; Viruses

Topics: Adult; Anemia, Hemolytic; Female; Humans; Mycoplasma Infections; Myocarditis; Pleural Effusion; Pneumonia; Tetracycline

Topics: Adult; Drug Hypersensitivity; Female; Humans; Myocardial Infarction; Myocarditis; Tetracycline

Topics: Abdomen; Adolescent; Adult; Aged; Anti-Bacterial Agents; Bronchiectasis; Child; Cholecystitis; Female; Humans; Injections, Intravenous; Lung Abscess; Lung Diseases; Male; Middle Aged; Morpholines; Myocarditis; Oleandomycin; Osteomyelitis; Pancreatitis; Peritonitis; Pneumonia; Tetracycline; Thoracic Surgery; Thorax

Topics: Adult; Animals; Child; Female; Hepatitis; Humans; Male; Meningoencephalitis; Middle Aged; Myocarditis; Psittaciformes; Psittacosis; Respiratory Tract Infections; Tetracycline; Zoonoses

Topics: Adult; Anti-Bacterial Agents; Chloramphenicol; Diabetic Neuropathies; Exudates and Transudates; Female; Humans; Male; Meningitis; Myocarditis; Penicillins; Pregnancy; Puerperal Infection; Streptococcal Infections; Streptococcus; Streptomycin; Tetracycline; Vaginal Smears

In Canada, about 100 sporadically occurring cases of brucellosis are reported yearly. Three patients were admitted to one Montreal hospital in the first seven months of 1963; all were employed in or around a packing plant. One had pain and electrocardiographic changes suggestive of Brucella myocarditis; he recovered promptly. Symptoms of neurasthenia and anxiety are common and were observed in two of these three cases. Two had positive blood cultures; the third showed conclusive agglutination to Br. abortus (1:10,240). In some patients with frequent previous exposures to infection the agglutination response may be equivocal and difficult to interpret. All three patients responded well to tetracycline; streptomycin and corticosteroids also have a role in the therapy of some cases. There may also be some place for combined antibiotic and vaccine therapy. The program of control of the disease in cattle in Canada is aimed at eradication by 1967.

Topics: Animals; Anti-Bacterial Agents; Antigen-Antibody Reactions; Aspartate Aminotransferases; Brucella; Brucella abortus; Brucellosis; Canada; Cattle; Demeclocycline; Drug Therapy; Electrocardiography; Epidemiology; Hospitals, Veterans; Humans; Male; Meat-Packing Industry; Myocarditis; Occupational Diseases; Pain; Streptomycin; Tetracycline; United States; Veterans; Zoonoses

Topics: Female; Fetal Diseases; Fetus; Gastrointestinal Tract; Humans; Kidney Diseases; Liver Diseases; Maternal-Fetal Exchange; Myocarditis; Pregnancy; Pregnancy, Animal; Rabbits; Research; Tetracycline; Tetracyclines; Toxicology