tetracycline and Mouth-Neoplasms

In a pilot study, we showed that topical administration of a tetracycline could decrease oral bacteria levels for 6 hours in patients who underwent oral cancer surgery combined with tracheotomy and flap reconstruction. This multicenter, randomized control trial aimed to investigate the effectiveness of topical application of tetracycline ointment for prevention of surgical site infection (SSI) associated with major oral cancer surgery.. One hundred seventeen patients who underwent oral cancer resection combined with neck dissection, flap reconstruction, and tracheotomy were divided randomly into an intervention group (n = 56) and a control group (n = 61). The intervention consisted of topical administration of tetracycline ointment on the dorsum of the tongue every 6 hours for 48 hours postoperatively. Factors relating to the occurrence of SSI in both groups were subjected to logistic regression analysis.. SSI occurred in 11 patients (19.6%) in the intervention group and 22 patients (36.1%) in the control group. Multivariate analysis showed that a longer operating time and not receiving topical tetracycline were independent risk factors for development of SSI.. Administration of topical tetracycline for 48 hours postoperatively is an effective way of preventing SSI after oral cancer surgery.

Topics: Administration, Topical; Aged; Anti-Bacterial Agents; Carcinoma, Squamous Cell; Female; Humans; Male; Mouth Neoplasms; Pilot Projects; Surgical Flaps; Surgical Wound Infection; Tetracycline; Treatment Outcome

Parenteral antibiotic prophylaxis is the current standard of therapy in clean-contaminated oral cancer surgery. Nevertheless, the incidence of surgical site infection (SSI) in oral oncological surgery is relatively high, especially in major surgery with reconstruction and tracheotomy. The aims of this study were to investigate the perioperative condition related to microorganisms in the oral cavity and to examine the efficacy of the topical administration of tetracycline in reducing the number of bacteria in the oropharyngeal fluid during intubation. The number of oral bacteria was measured during intubation in patients undergoing major oral cancer surgery. The efficacy of the topical administration of tetracycline or povidone iodine gel in reducing the bacteria was then investigated. Bacteria in the oropharyngeal fluid grew from 10(6)CFU/ml to 10(8)CFU/ml during the 3h after intubation (CFU, colony-forming units). When tetracycline was applied to the dorsum of the tongue, oral bacteria decreased immediately to 10(5)CFU/ml, and the number of bacteria in the oropharyngeal fluid was maintained below 10(7)CFU/ml for 7h. The concentration of tetracycline in the oropharyngeal fluid was extremely high for several hours after topical administration. The topical administration of tetracycline could reduce oral bacteria in patients undergoing clean-contaminated oral cancer surgery. This method is expected to be effective in the prevention of SSI.

Topics: Administration, Topical; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antibiotic Prophylaxis; Female; Gels; Humans; Male; Middle Aged; Mouth Neoplasms; Neoplasm Staging; Pharmaceutic Aids; Povidone; Surgical Wound Infection; Tetracycline; Treatment Outcome

Topics: Adult; Anti-Bacterial Agents; Drug Evaluation; Female; Humans; Male; Middle Aged; Mouth Neoplasms; Mouthwashes; Nevus; Tetracycline; Treatment Outcome

Topics: Administration, Topical; Anti-Bacterial Agents; Child; Female; Humans; Mouth Mucosa; Mouth Neoplasms; Mouthwashes; Nevus; Tetracycline

Topics: Administration, Oral; Adult; Female; Humans; Mouth Mucosa; Mouth Neoplasms; Nevus, Pigmented; Suspensions; Tetracycline

Topics: Amphotericin B; Animals; Carcinoma; Cell Line; Cell Survival; Culture Media; Depression, Chemical; Dose-Response Relationship, Drug; Drug Synergism; HeLa Cells; Humans; L Cells; Leucine; Mice; Mouth Neoplasms; Polymyxins; Protein Biosynthesis; Rifampin; RNA, Neoplasm; Tetracycline; Tritium; Uridine

Topics: Administration, Oral; Adult; Aged; Biopsy; Carcinoma, Adenoid Cystic; Carcinoma, Squamous Cell; Female; Fluorescence; Humans; Injections, Intravenous; Laryngeal Neoplasms; Leukoplakia; Lymphoma; Male; Methods; Middle Aged; Mouth Neoplasms; Neoplasm Metastasis; Pharyngeal Neoplasms; Tetracycline; Time Factors

Topics: Fluorescence; Humans; Mouth Neoplasms; Tetracycline

Topics: Adolescent; Adult; Aged; Humans; Middle Aged; Mouth Neoplasms; Tetracycline

Topics: Avitaminosis; Carcinoma, Squamous Cell; Denture, Complete; Gingival Diseases; Hematologic Diseases; Humans; Male; Middle Aged; Mouth Neoplasms; Poisoning; Stomatitis, Aphthous; Tetracycline; Ulcer

Topics: Adult; Aged; Fluorescence; Humans; Middle Aged; Mouth Neoplasms; Nose Neoplasms; Tetracycline; Tonsillar Neoplasms