tetracycline and Monkey-Diseases

Stool specimens collected systematically from a group of Celebes black macaques (Macaca nigra) with a high incidence of diarrhea were examined microbiologically. Numerous isolates of Shigella flexneri, Campylobacter jejuni and pathogenic Escherichia coli were recovered. Previous parasitology reports had revealed that the majority of the animals had Balantidium coli. Subsequently, the group was treated with trimethoprim-sulfamethoxazole, erythromycin and tetracycline. After treatment, Shigella flexneri was not detected in the stool of any animal for 1 year, and the clinical condition of the group was improved. Reduced recovery rates were obtained with other enteric pathogens.

Topics: Animals; Drug Combinations; Drug Therapy, Combination; Dysentery, Bacillary; Erythromycin; Macaca; Monkey Diseases; Shigella flexneri; Sulfamethoxazole; Tetracycline; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

Two of 4 untreated vervet monkeys infected with Borrelia hermsii survived and were resistant to reinfection for at least 1 year. Seven of 9 vervets receiving tetracycline could be reinfected after 12 to 36 weeks. Immobilizine could be demonstrated for a shorter time in treated than in untreated vervets.

Topics: Animals; Antibodies, Bacterial; Borrelia Infections; Cercopithecus; Chlorocebus aethiops; Female; Haplorhini; Male; Monkey Diseases; Tetracycline; Time Factors

From 1964 to 1967, 6,646 monkeys, representing 10 primate species, were examined for Shigella and Salmonella infections upon arrival at the National Center for Primate Biology. Of these animals, 12% were infected with Shigella, and 75% of the Shigella isolates were S. flexneri 4. The incidence of Salmonella infections decreased from 12 to 3% during the period of study. Epidemiological studies of animals in the colony for 90 days or more indicated no seasonal variation in the occurrence of Shigella and Salmonella. Many of the isolates from incoming monkeys as well as from laboratory-conditioned animals were resistant to chloramphenicol, dihydrostreptomycin, and tetracycline. The possible operation of drug-resistance factors in these infections is discussed.

Topics: Animals; Chloramphenicol; Dihydrostreptomycin Sulfate; Drug Resistance, Microbial; Dysentery, Bacillary; Monkey Diseases; Neomycin; Salmonella; Salmonella Infections, Animal; Seasons; Shigella; Tetracycline