tetracycline and Mandibular-Diseases

The treatment of molar furcation defects remains a considerable challenge in clinical practice. The degree of success in the management of furcation involvement is highly variable and inversely related to initial probing depth (PD) measurements in these lesions. The identification of clinical measurements influential to the treatment outcomes is critical to optimize the results of surgical periodontal therapy. Therefore, the objective of this study was to evaluate the clinical response of mandibular buccal Class II furcation lesions to a combined regenerative treatment modality.. Sixty patients were divided into two (n = 30) treatment groups. An experimental combined regenerative therapy (ET) was compared to open flap debridement (OFD). The ET was a combination of a composite graft consisting of bioabsorbable hydroxyapatite and tetracycline (3:1), a guided tissue regeneration barrier, and a coronally advanced flap. The clinical variables evaluated were plaque, bleeding on probing, gingival recession, PD, vertical attachment level (VAL), horizontal attachment level (HAL), furcation vertical height, furcation horizontal depth, and the amount of tissue under the barrier membrane at uncovering. Reevaluation was performed 12 months after the surgical procedure.. Both treatments resulted in improvements in all clinical variables evaluated. Postoperative measurements revealed a reduction in PD of 3.65 +/- 0.6 mm and 0.60 +/- 1.0 mm; VAL gains of 3.05 +/- 0.6 mm and 0.65 +/- 0.6 mm and HAL gains of 3.45 +/- 1.3 mm and 0.55 +/- 0.7 mm in the ET and OFD groups, respectively. In the ET group, significant positive correlations were found between baseline PD and PD reduction at 12 months, and the initial VAL correlated positively with PD reduction and HAL gain. The horizontal furcation depth and amount of tissue formed under the membrane at uncovering correlated positively with PD reduction and HAL and VAL gains. For the OFD group, the initial PD correlated positively with PD reduction and VAL and HAL gains and correlated negatively with recession. Initial VAL correlated positively with PD reductions and VAL and HAL gains. The initial HAL correlated negatively with recession at 12 months.. ET exhibited significantly better clinical results, with more PD reduction, HAL and VAL gains, and a higher frequency of furcation closure compared to OFD and showed promise as a regenerative treatment technique. The ability to predict a response to treatment based upon pretreatment parameters was not consistent between groups; thus, prediction of treatment outcomes based on pretreatment measurements should be carefully evaluated for each treatment modality.

Topics: Absorbable Implants; Adult; Alveoloplasty; Anti-Bacterial Agents; Bone Regeneration; Bone Substitutes; Debridement; Dental Plaque Index; Durapatite; Female; Follow-Up Studies; Furcation Defects; Gingival Hemorrhage; Gingival Recession; Guided Tissue Regeneration, Periodontal; Humans; Male; Mandibular Diseases; Membranes, Artificial; Middle Aged; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Prospective Studies; Surgical Flaps; Tetracycline; Treatment Outcome

Treatment of osteitis in the mandible after surgery is still a clinical problem. Levels of three tetracyclines--doxycycline, oxytetracycline and tetracycline--were measured in serum and dental alveolar serum in 30 patients undergoing oral surgery. The serum concentrations were higher than the dental alveolar serum concentrations in all patients. The maximal concentration in the alveolar serum for doxycycline was between 3.0 and 3.5 mug/ml while the corresponding values for oxytetracycline and tetracycline were between 1.0 and 2.0 mug/ml. When the dental alveolar serum concentrations of the various tetracycline analogues were related to their range of inhibitory concentrations for microorganisms isolated from mandibular osteitis, it was found that each drug reached levels sufficient to inhibit most but not all strains.

Topics: Administration, Oral; Adult; Clinical Trials as Topic; Doxycycline; Drug Evaluation; Female; Humans; Male; Mandibular Diseases; Microbial Sensitivity Tests; Middle Aged; Osteitis; Oxytetracycline; Tetracycline

The aim of the present study was to construct a nonvascular transport disc to repair the canine mandibular defects model and to perform a dynamic analysis of the new bone obtained by nonvascular transport distraction osteogenesis (NTDO) in canines.. Thirty adult dogs were randomly divided into 3 groups, with 10 dogs in each group. Canine mandibular defect models of NTDO were constructed. All the dogs were marked by tetracycline hydrochloride at a different distraction stage. The dogs were euthanized at 2, 4, and 12 weeks after distraction, and the quality ratio of calcium and phosphate for the new bone was measured using electron dispersive spectroscopy.. The canine mandibular defects were successfully repaired. Using tetracycline hydrochloride, we successfully observed the quality and speed of new bone formation. The quality ratio of calcium and phosphate was similar between the new bone formation and the original bone. The time spent using a nonvascular transport disc to repair mandibular defects was consistent with using a vascularized transport disc, and the quality of the new bone and the original bone was exactly the same.. When the bone mass is insufficient or the conditions are not suitable for a vascularized transport disc, the nonvascular transport disc can be used as an alternative.

Topics: Animals; Bone Matrix; Bone Regeneration; Calcium; Disease Models, Animal; Dogs; Fluorescent Dyes; Mandible; Mandibular Diseases; Microscopy, Electron, Scanning; Osteogenesis; Osteogenesis, Distraction; Phosphates; Random Allocation; Spectrometry, X-Ray Emission; Tetracycline; Time Factors

In this technical approach, we demonstrate that preoperative tetracycline administration helps distinguish between viable and necrotic bone in osteoradionecrosis (ORN) during surgery by exciting tetracycline fluorescence by black light. The difficult aspect of the operative approach lies in the decision of the extent of the debridement in order to prevent an iatrogenic fracture or progression of ORN. With this technique, vital bone, in contrast to necrotic bone, showed detectable fluorescence. Therefore, tetracycline fluorescence labeling may be used in attempts to facilitate the intraoperative decision making in the surgical therapy of osteoradionecrosis.

Topics: Cranial Irradiation; Fluorescent Dyes; Humans; Male; Mandibular Diseases; Middle Aged; Monitoring, Intraoperative; Osteoradionecrosis; Preoperative Care; Tetracycline; Ultraviolet Rays

The aim of this study was that to determine the clinical and histologic results of a new hydroxyapatite, with innovative properties compared with the other alloplastic materials used in the regenerative treatment of grade 3 bony defects of the mandibular furcations in the human. The hydroxyapatite used in our research is characterized by a scarce density and crystallinity, while from a microstructural point of view, the granules have nanometric dimensions (0.05-0.1 microm). The patient reported here by the authors had a grade 3 infrabony defect into a mandibular furcation. The surgical procedure used consists of the creation of a flap, roots planing, the conditioning of the roots with tetracycline HC, the accurate positioning of the granules of the hydroxyapatite in the furcation area, the crown replacing of the flap, and finally the suture of the same. Six months after the insertion of hydroxyapatite, the clinical effect was studied, comparing the variations found in probing the insertion of depth. At the end of the treatment, a block section of the molar was performed, with part of the surrounding soft tissues, whose histologic analysis underlined the moderate and initial formation of bony tissue, periodontal ligament, and radicular cement in the middle and lower portion of the furcation. In light of these results, the authors conclude that the use of this new hydroxyapatite is promising in the treatment of the mandibular furcations in the human, even if it will be necessary to continue to test its effectiveness through more studies.

Topics: Adult; Alveolar Bone Loss; Anti-Bacterial Agents; Bone Regeneration; Bone Substitutes; Durapatite; Female; Follow-Up Studies; Furcation Defects; Guided Tissue Regeneration, Periodontal; Humans; Mandibular Diseases; Molar; Root Planing; Surgical Flaps; Suture Techniques; Tetracycline

Topics: Anti-Bacterial Agents; Chronic Disease; Debridement; Female; Fluorescent Dyes; Humans; Mandible; Mandibular Diseases; Middle Aged; Necrosis; Osteomyelitis; Staining and Labeling; Tetracycline; Ultraviolet Rays

Topics: Adult; Anti-Bacterial Agents; Diagnosis, Differential; Female; Granuloma, Giant Cell; Humans; Iatrogenic Disease; Mandibular Diseases; Odontogenic Cysts; Petrolatum; Tetracycline

Mucosal changes have been well described in chronic sinusitis, yet little is known about the underlying bone, despite clinical and experimental evidence suggesting that bone may be involved in chronic sinusitis. Techniques of undecalcified bone analysis were used for detailed histologic examination of ethmoid bone in chronic sinusitis compared with controls. Bone synthesis, resorption, and inflammatory cell presence were specifically assessed. Additionally, histomorphometry techniques were used to determine ethmoid bone physiology in individuals undergoing surgery for chronic sinusitis. Overall, individuals undergoing surgery for chronic sinusitis were found to have evidence of marked acceleration in bone physiology with histologic changes including new bone formation, fibrosis, and presence of inflammatory cells. These findings are compared with osteomyelitis in long bone and the jaw. The suggestion that underlying bone may serve as a catalyst for chronic sinusitis is supported and implications for therapy are discussed.

Topics: Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Bone Remodeling; Bone Resorption; Chronic Disease; Coloring Agents; Demeclocycline; Edema; Endoscopy; Ethmoid Bone; Ethmoid Sinusitis; Female; Fibrosis; Humans; Male; Mandibular Diseases; Mucous Membrane; Osteitis; Osteogenesis; Osteomyelitis; Prospective Studies; Rhinitis; Single-Blind Method; Tetracycline; Turbinates

Histomorphometric techniques were used to evaluate the stress shielding effect in bilateral bone grafts in 4 Macaca fascicularis monkeys. Bilateral continuity defects were created and grafted by replacing the resected portion of the mandible and iliac crest bone into the defect area. Both sides were plated with rigid internal fixation plates. Three months after bone grafting, the plate was removed from one side while the other plate was left in place. The animals were sacrificed at 1, 4, 6, and 8 months after plate removal and the grafted areas removed for histomorphometric analysis. This study documents decreased bone volume as well as smaller interlabel width on the plated side, suggesting a stress shielding effect as a result of the rigid internal fixation plate.

Topics: Animals; Bone Plates; Bone Transplantation; Evaluation Studies as Topic; Image Processing, Computer-Assisted; Macaca fascicularis; Mandible; Mandibular Diseases; Microscopy, Fluorescence; Osteogenesis; Pilot Projects; Stress, Mechanical; Tetracycline

Topics: Child; Female; Humans; Kanamycin; Lung Diseases, Fungal; Mandibular Diseases; Mycetoma; Neomycin; Nocardia; Nocardia Infections; Penicillins; Radiography; Sulfadiazine; Tetracycline; Time Factors

Topics: Actinomycosis; Actinomycosis, Cervicofacial; Adult; Female; Humans; Injections, Intramuscular; Lincomycin; Lung Diseases, Fungal; Male; Mandibular Diseases; Middle Aged; Penicillins; Sulfamethoxazole; Tetracycline; Tooth Extraction

Topics: Actinomyces; Actinomycosis, Cervicofacial; Adult; Diagnosis, Differential; Female; Humans; Mandibular Diseases; Nocardia Infections; Tetracycline; Tooth Extraction