tetracycline and Lymphatic-Diseases

Whipple's disease is a systemic bacterial infection that once was uniformly fatal and now is treatable with several different antibiotics in most cases. The exact nature of the Whipple's bacillus is unknown, since the organism cannot consistently be cultured. There is also controversy concerning the role of immunologic dysfunction in patients with Whipple's disease. In addition to the small intestine, Whipple's disease can involve the remainder of the gastrointestinal tract, as well as the lymph nodes, joints, nervous system, heart, eyes, hematopoietic system, lungs, liver, and other organs. The clinical manifestations, diagnosis, and treatment of this rare but fascinating disease will be reviewed in this article.

Topics: Bacterial Infections; Diagnosis, Differential; Drug Combinations; Eye Diseases; Heart Diseases; Hematologic Diseases; Humans; Joint Diseases; Lung Diseases; Lymphatic Diseases; Muscular Diseases; Nervous System Diseases; Penicillins; Skin Diseases; Streptomycin; Sulfamethoxazole; Tetracycline; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Whipple Disease

Topics: Chancroid; Diagnosis, Differential; Female; Haemophilus; Humans; Lymphatic Diseases; Male; Sulfonamides; Tetracycline

Topics: Abattoirs; Abscess; Agglutination Tests; Animals; Body Weight; Brucella; Brucella abortus; Brucellosis; Cattle; Chloramphenicol; Epididymitis; Fever; Humans; Illinois; Iowa; Lymphatic Diseases; Male; Occupational Diseases; Pyridazines; Splenomegaly; Streptomycin; Sulfanilamides; Tetracycline

Topics: Acne Vulgaris; Alopecia Areata; Dermatitis, Contact; Humans; Lupus Erythematosus, Systemic; Lymphatic Diseases; Methotrexate; Ointments; Photosensitivity Disorders; Porphyrias; Psoriasis; Rosacea; Skin Diseases; Steroids; Sunscreening Agents; Tetracycline; Tinea; Trichophyton; Urea; Vitiligo

Topics: Albuminuria; Anemia; Arrhythmias, Cardiac; Aspartate Aminotransferases; Chloramphenicol; Conjunctivitis; Evaluation Studies as Topic; Fever; Hepatomegaly; Humans; Hypotension, Orthostatic; Leukopenia; Lymphatic Diseases; Male; Military Medicine; Recurrence; Scrub Typhus; Skin Ulcer; Splenomegaly; Tetracycline

Tularemia is a zoonotic disease of the northern hemisphere. Oculoglandular tularemia is the rarest form, comprising 1.4-4.2% of all cases. We present a patient with oculoglandular tularemia that did not respond to gentamicin to demonstrate the need for prolonged antimicrobial treatment and surgical intervention.

Topics: Adolescent; Anti-Bacterial Agents; Eye Infections, Bacterial; Gentamicins; Humans; Lymph Nodes; Lymphatic Diseases; Magnetic Resonance Imaging; Male; Masseter Muscle; Neck; Parotid Gland; Streptomycin; Tetracycline; Treatment Outcome; Tularemia

The BCR/ABL fusion protein is found in more than 90% of patients with chronic myeloid leukemia (CML) as well as in a subset of patients with acute B-cell leukemia. We have previously described a transgenic model for an inducible and reversible acute B-cell leukemia caused by p210 BCR/ABL. Here, we describe a new model of an inducible BCR/ABL disease by directing the expression of the oncogene to megakaryocytic progenitor cells within the murine bone marrow using the tetracycline-responsive expression system under the control of human CD34 regulatory elements. The predominant feature was the development of a chronic thrombocytosis. The condition progressed with the development of splenomegaly accompanied by lymphadenopathy in some mice. Affected animals demonstrated a dramatic increase in the number of megakaryocytes in the bone marrow and the spleen. Immunohistochemistry demonstrated that the reporter gene was expressed in hematopoietic stem cells (HSCs), common myeloid progenitor (CMP) cells, as well as in megakaryocytic/erythroid progenitor cells (MEPs). Although these mice did not display the increase in granulopoiesis commonly found in chronic myeloid leukemia (CML), the phenotype closely resembles a myeloproliferative disorder affecting the megakaryocytic lineage observed in some patients with the BCR/ABL P210 translocation.

Topics: Animals; Antigens, CD34; Disease Models, Animal; Fusion Proteins, bcr-abl; Gene Expression Regulation; Genes, Regulator; Genetic Vectors; Hematopoietic Stem Cells; Humans; Lymphatic Diseases; Megakaryocytes; Mice; Mice, Transgenic; Myeloproliferative Disorders; Splenomegaly; Tetracycline; Thrombocytosis

Numerous diseases can lead to multilocular lesions of the liver. The authors report a rare pediatric case of hepatic granulomas due to Pasteurella multocida: a 7-year-old girl with chronic fever was investigated by sonography and CT scan, demonstrating mesenteric lymph node enlargement and numerous small hepatic lesions. After surgical biopsy, histopathology of the liver specimens showed pyogenic granuloma, with serologic testing positive for Pasteurella multocida. Treatment with a tetracycline and corticosteroids was successful. Pasteurella multocida infection, despite its habitual benign course, should be suspected among differential diagnoses of lymphogranulomatous affections with hepatic involvement. No case of liver and lymph node foci in a child has been previously described.

Topics: Anti-Bacterial Agents; Antibodies, Bacterial; Child; Diagnosis, Differential; Drug Therapy, Combination; Female; Follow-Up Studies; Glucocorticoids; Granuloma; Hepatitis; Humans; Lymphatic Diseases; Pasteurella Infections; Pasteurella multocida; Tetracycline; Tomography, X-Ray Computed

Pelvic lymphocysts developed in 3 of 124 patients undergoing radical surgery for cervical cancer. All were managed by percutaneous aspiration under local anesthesia in an outpatient setting. Sclerosis was required in one patient. This management plan is superior to laparotomy in being less morbid and equally effective.

Topics: Adenocarcinoma; Adult; Anesthesia, Local; Drainage; Female; Humans; Hysterectomy; In Vitro Techniques; Lymphatic Diseases; Lymphocele; Middle Aged; Postoperative Complications; Tetracycline; Uterine Cervical Neoplasms

Two hundred neck dissections performed at Toronto General Hospital over a 3 year period are reviewed. There were six intra-operative lymph leaks and five postoperative chylous fistulae. The postoperative chylous fistulae are analysed in detail and the approach to conservative management of lymph leaks is discussed. Two cases required re-exploration of the neck; difficulty in identifying the site of leakage and of sealing lymph channels is discussed. Also reported is the successful use of topical tetracycline powder in two cases and a review of the various treatment modalities advocated in the literature.

Topics: Aged; Chyle; Fistula; Humans; Lymph; Lymphatic Diseases; Male; Middle Aged; Neck; Nutritional Requirements; Postoperative Complications; Retrospective Studies; Tetracycline

Structure of the thymus in Wistar rats has been studied during antenatal and early postnatal periods of ontogenesis by means of histological, morphometric and electron microscopic methods. Theraputic doses of tetracycline hydrochloride have been administered during fetogenesis (15-20 days of pregnancy). An accelerated formation of the thymic structures, cellular blasttransformation in the thymic cortex and movement of lymphocytes from the cortex into medulla and increased secretory activity of epithelioreticulocytes have been revealed. The data obtained are considered as a display of the organ's immune response to tetracycline administration.

Topics: Animals; Female; Immunologic Deficiency Syndromes; Lymphatic Diseases; Maternal-Fetal Exchange; Pregnancy; Rats; Tetracycline; Thymus Gland

Ante- and postnatal development of anatomical structures and cells of lymphatic nodes has been studied in rat offspring subjected to tetracycline effect during placentation and organogenesis (the 8th-14th days) and during fetogenesis (the 15th-20th days). Tetracycline injection during the 8th-14th days of embryogenesis results in certain disturbances of the nodular structure formations, inhibition of lympho- and plasmo-cytopoesis against the background of a sharp increase in number of basophilic granulocytes and tissue basophils. The antibiotic effect on the 15th-20th days of embryogenesis does not disturb the lymph node formation, but produces an increasing number of lymphocytes, plasmocytes, macrophages, eosinophilic granulocytes and tissue basophils in them.

Topics: Animals; Bronchi; Female; Gestational Age; Lymph Nodes; Lymphatic Diseases; Maternal-Fetal Exchange; Mesentery; Pregnancy; Rats; Rats, Inbred Strains; Tetracycline; Trachea

Topics: Aged; Diagnosis, Differential; Diagnostic Errors; Haemophilus Infections; Haemophilus influenzae; Humans; Intestinal Mucosa; Intestine, Small; Lymphatic Diseases; Male; Prostatic Neoplasms; Tetracycline; Whipple Disease

Topics: Adult; Biopsy; Complement Fixation Tests; Humans; Lymphatic Diseases; Lymphogranuloma Venereum; Male; Military Medicine; Skin Tests; Tetracycline; Thailand; Tongue Diseases; United States

Topics: Adult; Diagnosis, Differential; Humans; Intestine, Small; Jejunum; Lymphatic Diseases; Male; Microscopy, Electron; Radiography; Sarcoidosis; Tetracycline; Whipple Disease

Topics: Antibodies; Bacteria; Bone Diseases; Child, Preschool; Female; Gentamicins; Granuloma; Humans; Lymphatic Diseases; Male; Necrosis; Tetracycline; Tonsillitis

Topics: Animals; Anti-Bacterial Agents; Cattle; Cattle Diseases; Evaluation Studies as Topic; Lymphatic Diseases; Penicillins; Procaine; Sodium Chloride; Streptomycin; Tetracycline

Topics: Adult; Betamethasone; Bone Marrow Examination; Chloramphenicol; Cytoplasm; Eosinophils; Hemorrhage; Humans; Kidney; Liver; Lymph Nodes; Lymphatic Diseases; Male; Oleandomycin; Pancreas; Reticulocytes; Spleen; Tetracycline

Topics: Adolescent; Agammaglobulinemia; Diarrhea; Giardiasis; Humans; Hyperplasia; Infusions, Parenteral; Intestinal Diseases; Intestine, Small; Jejunum; Lymphatic Diseases; Lymphatic System; Male; Plasma; Quinacrine; Radiography; Tetracycline

Topics: Aged; Connective Tissue; Humans; Lymphatic Diseases; Male; Tetracycline

Topics: Animals; Bone Marrow; Exudates and Transudates; In Vitro Techniques; Leukocytes; Liver; Lymph Nodes; Lymphatic Diseases; Mice; Mononuclear Phagocyte System; Phagocytosis; Rabbits; Spleen; Staphylococcal Infections; Tetracycline

Topics: Anti-Bacterial Agents; Genetic Diseases, X-Linked; Leukemia, Hairy Cell; Lymphatic Diseases; Prednisone; Severe Combined Immunodeficiency; Tetracycline