tetracycline and Lung-Diseases

The purpose of this review is to give a comprehensive overview of transgenic mouse lines suitable for studying gene function and cellular lineage relationships in lung development, homeostasis, injury, and repair. Many of the mouse strains reviewed in this Perspective have been widely shared within the lung research community, and new strains are continuously being developed. There are many transgenic lines that target subsets of lung cells, but it remains a challenge for investigators to select the correct transgenic modules for their experiment. This review covers the tetracycline- and tamoxifen-inducible systems and focuses on conditional lines that target the epithelial cells. We point out the limitations of each strain so investigators can choose the system that will work best for their scientific question. Current mesenchymal and endothelial lines are limited by the fact that they are not lung specific. These lines are summarized in a brief overview. In addition, useful transgenic reporter mice for studying lineage relationships, promoter activity, and signaling pathways will complete our lung-specific conditional transgenic mouse shopping list.

Topics: Animals; Cell Lineage; Connective Tissue Cells; Disease Models, Animal; Doxorubicin; Epithelial Cells; Gene Expression Regulation; Genes, Reporter; Integrases; Lung; Lung Diseases; Mice; Mice, Transgenic; Species Specificity; Tamoxifen; Tetracycline

We report the case of a 60 year female patient suffering from rheumatoid arthritis for the last 25 years, under TNF-blocker and leflunomide, affected by a recurrent pneumothorax with several subpleural nodules, basal bronchiectasis and apical bullous emphysema. The patient was administered several treatments: aspiration, talc pleurodesis, surgical pleurodesis, pleurodesis induced by tetracycline and autologous blood. To allow the pleural inflammatory reaction necessary to the success of the pleurodesis, we had to interrupt the treatment by TNF-blocker and leflunomide. We then witnessed a partial pleurodesis with persistence of a pneumothorax. The medical situation is improving with disappearance of dyspnea.

Topics: Anti-Bacterial Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Bronchiectasis; Dyspnea; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lung Diseases; Middle Aged; Pleural Diseases; Pleurodesis; Pneumothorax; Pulmonary Emphysema; Radiography, Thoracic; Recurrence; Tetracycline; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha

Whipple's disease is a systemic bacterial infection that once was uniformly fatal and now is treatable with several different antibiotics in most cases. The exact nature of the Whipple's bacillus is unknown, since the organism cannot consistently be cultured. There is also controversy concerning the role of immunologic dysfunction in patients with Whipple's disease. In addition to the small intestine, Whipple's disease can involve the remainder of the gastrointestinal tract, as well as the lymph nodes, joints, nervous system, heart, eyes, hematopoietic system, lungs, liver, and other organs. The clinical manifestations, diagnosis, and treatment of this rare but fascinating disease will be reviewed in this article.

Topics: Bacterial Infections; Diagnosis, Differential; Drug Combinations; Eye Diseases; Heart Diseases; Hematologic Diseases; Humans; Joint Diseases; Lung Diseases; Lymphatic Diseases; Muscular Diseases; Nervous System Diseases; Penicillins; Skin Diseases; Streptomycin; Sulfamethoxazole; Tetracycline; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Whipple Disease

Topics: Anti-Bacterial Agents; Carbenicillin; Clindamycin; Diarrhea; Enterocolitis, Pseudomembranous; Erythromycin; Humans; Legionnaires' Disease; Lung Diseases; Male; Methicillin; Penicillin Resistance; Prostatitis; Staphylococcal Infections; Staphylococcus aureus; Streptococcus pneumoniae; Tetracycline; Urethritis; Vancomycin

Topics: Bacteriological Techniques; Diagnosis; Embolism; Endocarditis, Bacterial; Erythromycin; Fever; Heart Defects, Congenital; Heart Valves; Humans; Lung Diseases; Penicillin Resistance; Penicillins; Pneumococcal Infections; Postoperative Complications; Prognosis; Sepsis; Staphylococcal Infections; Streptococcal Infections; Streptomycin; Tetracycline; Vancomycin

The results from the comparative clinical studies on the effectiveness of tetraolean and tetracycline are summed up about 1672 patients with acute and exacerbated infections of the respiratory organs (1036 patient, treated by ten teams, working on the theme given in advance "Comparative clinical studies between tetraolean and tetracyclin in acute pneumonia", 164 patients with postgrippe viral-bacterial pneumonia, treated during the grippe epidemy 1972/1973 and 445 patient treated at the Therapeutic Clinic, Sofia during 1967-1972). The total results reveal that, according to the adopted objective indices, the therapeutic effect of tetraolean is with a statistically significant superiority over tetracyclin. The beneficial results obtained in the treatment of 14 patients with endocarditis lenta are also reported. The mechanisms of that superior effect, defined as "clinical synergism" are discussed.

Topics: Acute Disease; Bulgaria; Chronic Disease; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Endocarditis, Subacute Bacterial; Humans; Influenza, Human; Lung Diseases; Oleandomycin; Pneumonia; Tetracycline

Topics: Acute Disease; Adolescent; Adult; Aged; Bacterial Infections; Biguanides; Clinical Trials as Topic; Doxycycline; Female; Humans; Lung Diseases; Male; Methacycline; Middle Aged; Tetracycline; Urticaria

Topics: Child; Child, Preschool; Female; Humans; Infant; Lung Diseases; Male; Measles; Penicillins; Tetracycline

Topics: Aged; Bronchial Diseases; Candida; Humans; Lung Diseases; Nystatin; Tetracycline

Neutrophil activation with concomitant matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) release has been implicated in the development of sepsis-induced acute lung injury. We hypothesized that COL-3, a chemically modified tetracycline known to inhibit MMP-2 and MMP-9, would reduce lung injury and improve survival in rats following cecal ligation and puncture (CLP).. Sprague-Dawley rats were separated into five groups: 1) sham CLP+ carboxymethylcellulose (CMC; vehicle for COL-3, n = 6); 2) sham CLP + COL-3 (n = 6); 3) CLP + CMC (n = 10); 4) CLP + single-dose (SD) COL-3 administered concomitant with CLP (n = 9); and 5) CLP + multiple-dose (MD) COL-3 administered concomitant with CLP and at 24 h after CLP (n = 15). Rats were sacrificed at 168 h (7 days) or immediately after death, with survival defined as hours after CLP. Histological lung assessment was made based on neutrophil infiltration, alveolar wall thickening, and intraalveolar edema fluid. Lung MMP-2 and MMP-9 levels were assessed by immunohistochemistry. MMP-2 and MMP-9 levels were correlated with survival by simple regression analysis.. The mortality of rats in the cecal ligation and puncture without treatment group (CLP + CMC) was 70% at 168 h. A single dose of COL-3 in the CLP + COL-3 (SD) group significantly reduced mortality to 54%. Furthermore, with a repeat dose of COL-3 at 24 h after CLP, mortality was significantly reduced to 33%. Pathologic lung changes seen histologically in the CLP + CMC group were significantly reduced by COL-3. A significant reduction in lung tissue levels of MMP-2 and MMP-9 was noted in both groups treated with COL-3. Reduction of MMP-2 and MMP-9 levels correlated with improved survival.. Inhibition of MMP-2 and MMP-9 by COL-3 in a clinically relevant model of sepsis-induced acute lung injury reduces pulmonary injury and improves survival in a dose-dependent fashion. Our results suggest that prophylactic treatment with COL-3 in high-risk patients may reduce the morbidity and mortality associated with sepsis-induced acute respiratory distress syndrome.

Topics: Animals; Cecum; Chromatography, High Pressure Liquid; Disease Models, Animal; Enzyme Inhibitors; Ligation; Lung; Lung Diseases; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Punctures; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Sepsis; Tetracycline; Tetracyclines

Brucellosis is a classical zoonosis caused by a Gram-negative bacillus of the genus Brucella. Human brucellosis can either be acute or chronic and present with a variety of manifestations, mostly with fever and signs of musculo-skeletal involvement. It may be complicated by involvement of the cardiovascular, central nervous or genito-urinary systems. However, pulmonary brucellosis is a rare complication. We report a case of miliary and reticulo-nodular brucellar pneumonia with positive blood and sputum cultures and positive serological tests. To the best of our knowledge this is the first case to be reported from Israel of miliary pneumonia with sputum positive for brucellosis.

Topics: Adult; Brucellosis; Drug Therapy, Combination; Humans; Lung Diseases; Male; Radiography; Rifampin; Tetracycline

The epidemiology and etiology of spontaneous pneumothorax (SP) are shifting away from the predominance of subpleural bleb disease as emphasized by most reports since that of Kjaergaard (Sweden, 1932). We conducted a retrospective review of all patients admitted to a large urban hospital with the diagnosis of SP over the past 8 years. Of 120 patients, 32 had the acquired immunodeficiency syndrome (AIDS) (group 1, 26.6%), 43 patients had classic subpleural bleb disease or chronic obstructive pulmonary disease with blebs (group 2, 35.8%), and 45 patients had nonbleb disease exclusive of AIDS (group 3, 37.5%). These three groups were studied with respect to primary success rates with differing modalities of therapy. Bilateral SP occurred in 34% of group 1 patients, 2% of group 2 patients, and 11% of group 3 patients. The in-hospital mortality was 34% in group 1 compared with 2% in group 2 and 4% in group 3. Thirty-four percent of group 1 patients had recurrent SP compared with 16% of group 2 patients and 8% of group 3 patients. This report describes the changing etiology and epidemiology of SP in a large urban hospital from 1983 to 1991 and represents the largest single-institution report of AIDS-related pneumothorax. Standardized therapy was shown to have predictably favorable results in patients with bleb disease and nonbleb disease exclusive of AIDS. SP in patients with AIDS was associated with a high mortality rate and primary treatment failure; small-bore catheters and nondrainage therapies have a very limited role in these patients.

Topics: Acquired Immunodeficiency Syndrome; Catheterization; Chest Tubes; Humans; Lung Diseases; Lung Diseases, Obstructive; Oxygen Inhalation Therapy; Pleural Diseases; Pneumothorax; Punctures; Retrospective Studies; Suction; Tetracycline; Texas; Time Factors; Tissue Adhesions

The effects of subinhibitory concentrations of tetracycline on surface expression of Pseudomonas aeruginosa ferripyochelin binding protein (FBP) and P. aeruginosa virulence in a pulmonary infection model in rats were examined. Rats were inoculated intratracheally with P. aeruginosa strain DG1 embedded in agar beads. One half of the inoculated animals served as untreated controls while the other half received daily injections of 15 mg/kg tetracycline. FBP was shown to be surface exposed in bacteria isolated from control animals using indirect immunofluorescence and immunoelectron microscopy. No FBP was detectable, however, on the surface of bacteria isolated from the lungs of animals treated with tetracycline. The numbers of bacteria recovered from the lungs of infected animals did not differ between control and tetracycline treated groups, although the degree of pathology observed in tetracycline treated animals was significantly lower than in untreated controls (P = 0.002, one way ANOVA). Sub-inhibitory doses of tetracycline reduced proteolytic activity in vitro, but had no effect on the activities of exotoxin A or exoenzyme S. These studies suggest that exposure to subinhibitory concentrations of tetracycline can repress FBP surface expression as well as proteolytic activity in P. aeruginosa leading to a significant decrease in lung injury during infections due to this organism.

Topics: Animals; Bacterial Proteins; Bronchoalveolar Lavage Fluid; Carrier Proteins; Cell Membrane; Lung; Lung Diseases; Membrane Proteins; Pseudomonas aeruginosa; Rats; Rats, Inbred Strains; Tetracycline; Virulence

Tetracycline and erythromycin concentrate highly in pulmonary tissues in humans as well as in the rat. Their binding to the lung, whatever the species and the pathological state, is weak. Their intrapulmonary concentrations could be explained by a passive diffusion which depends on the pH variation between the intra- and extratissue compartments, the percentage of un-ionized form present, and their liposolubility. The importance of retention of tetracycline and erythromycin by plasma proteins is demonstrated by the decrease of their pulmonary index of penetration (IP, the intra- and extratissue concentrations ratio). The IP values are, respectively, 1.09 and 1.23 for tetracycline and erythromycin. These concentrations are in excess of their minimal inhibitory concentrations for bacteria responsible for pneumopathies. The lung homogenate binding of these antibiotics is weak (5% for erythromycin and 33% for tetracycline), corresponding to a nonsaturable binding to three main subcellular fractions (nucleus, mitochondria, and cytosol). Tetracycline has the same penetration in healthy or cancerous human lungs, whereas erythromycin presents a decreased IP in cancerous tissue. However, the binding of these antibiotics to healthy or cancerous lung homogenates is similar. So, the structure of cancerous cells is solely responsible for this modification of erythromycin penetration. The intrapulmonary concentration of tetracycline is increased in rat lungs infected by Legionella pneumophila. This modification is due to a great bacteria retention. In contrast, erythromycin possesses the same IP in healthy and infected rat lungs.

Topics: Animals; Blood Proteins; Erythromycin; Extracellular Space; Humans; Legionnaires' Disease; Lung; Lung Diseases; Male; Protein Binding; Rats; Rats, Inbred Strains; Species Specificity; Spectrophotometry, Ultraviolet; Subcellular Fractions; Tetracycline; Tissue Distribution

We report a case of lung infection, clinically resembling tuberculosis, caused by Rhodococcus rubropertinctus. The patient had no apparent immunosuppression which is unusual for disease caused by the 'rhodochrous' complex. The infection responded successfully to oral anti-tuberculous therapy, which included rifampicin, and to oral tetracycline.

Topics: Actinomycetales Infections; Administration, Oral; Australia; Female; Humans; Lung Diseases; Rhodococcus; Rifampin; Tetracycline; Vietnam

Topics: Adult; Homosexuality; Humans; Lung Diseases; Male; Radiography, Thoracic; Syphilis; Tetracycline; Tomography, X-Ray Computed

A retrospective analysis was made of all spontaneous pneumothoraces admitted to a Respiratory Unit between 1976 and 1981. There were 117 individuals responsible for 148 admissions, with a male to female ratio of 2: 1, giving a higher incidence amongst females than has been previously reported. Significantly fewer admissions were noted during May, June and July. Of the total survey population 89 per cent had smoked and in 40 per cent there was pre-existing lung disease. There was a history of two or more pneumothoraces in 36 per cent. Tetracycline pleurodesis, while attempted in 19 patients, was successful in only ten. Twelve patients underwent thoracotomy with a preponderance following right sided lesions. The duration of admission was more than 20 days for 17 per cent of the population. The aetiology, pathogenesis and management of pneumothorax is discussed.

Topics: Adolescent; Adult; Age Factors; Aged; Female; Humans; Intubation; Lung Diseases; Male; Middle Aged; Pneumothorax; Recurrence; Retrospective Studies; Scotland; Seasons; Sex Factors; Smoking; Suction; Tetracycline

Topics: Acute Disease; Adolescent; Adult; Brucellosis; Endocarditis, Bacterial; Female; Fever of Unknown Origin; Humans; Lung Diseases; Male; Middle Aged; Spinal Diseases; Streptomycin; Tetracycline

The clinical records of 7 patients referred to the National Jewish Hospital and Research Center over a 6-year period for evaluation of an abnormal chest x-ray and repeated sputum isolates of rapidly growing mycobacteria (Runyon's Group IV) were reviewed to determine the potential pathogenicity of these organisms. Mycobacterium fortuitum was isolated from 5 patients and Mycobacterium chelonei from 2. Haemoptysis, cough and weight loss were prominent in 6. Three had rheumatoid arthritis. Although two demonstrated cutaneous anergy, lymphocyte responsiveness to PHA was normal. PPD-F was not useful in skin testing or in the in vitro evaluation of lymphocyte function. Histologic examination of the lungs of 2 patients demonstrated caseating granulomata. One patient died of massive pulmonary haemorrhage soon after intiation of therapy. Multi-drug treatment regimens generally resulted in progressive sterilization of the sutum and improvement in the appearance of the chest x-ray. We conclude that some rapidly growing mycobacteria can cause potentially fatal cavitary lung disease and that intensive anti-tuberculosis therapy may successfully alter its course.

Topics: Adult; Aged; Antitubercular Agents; Ethionamide; Female; Humans; Lung Diseases; Male; Microbial Sensitivity Tests; Middle Aged; Mycobacterium; Mycobacterium Infections; Tetracycline

Good therapeutic results free of unwanted side-effects were observed in the management of acute and chronic non-tubercular bronchopneumopathies with an association of tetracyclin hydrochloride, proteolytic enzymes (trypsin and chymotrypsin), vanillic acid diethylamide and pyridophyllin.

Topics: Acute Disease; Adolescent; Adult; Aged; Bronchitis; Bronchopneumonia; Chronic Disease; Chymotrypsin; Drug Combinations; Drug Evaluation; Female; Humans; Lung Abscess; Lung Diseases; Male; Middle Aged; Tetracycline; Trypsin

Topics: Agranulocytosis; Amphotericin B; Anemia, Aplastic; Anemia, Hemolytic; Anti-Bacterial Agents; Ataxia; Bacitracin; Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Chloramphenicol; Deafness; Gastrointestinal Diseases; Gentamicins; Humans; Kanamycin; Kidney Diseases; Leukopenia; Lung Diseases; Neomycin; Neuromuscular Diseases; Nitrofurantoin; Optic Neuritis; Peripheral Nervous System Diseases; Skin Diseases; Streptomycin; Sulfonamides; Tetracycline; Thrombocytopenia; Vertigo

Topics: Adult; Aminosalicylic Acids; Blister; Carcinoma; Chronic Disease; Cough; Diagnosis, Differential; Humans; Isoniazid; Lung; Lung Diseases; Lung Neoplasms; Male; Radiography; Smoking; Spirometry; Sputum; Streptomycin; Syncope; Tetracycline; Tomography

Topics: Chronic Disease; Cyanosis; Humans; Inflammation; Lung Diseases; Male; Middle Aged; Osteoarthropathy, Secondary Hypertrophic; Penicillins; Pneumoconiosis; Smoking; Syndrome; Tetracycline; Tomography, X-Ray; Vasopressins

Topics: Chlamydia; Complement Fixation Tests; Humans; Lung Diseases; Psittacosis; Tetracycline

Topics: Breathing Exercises; Bronchodilator Agents; Humans; Lung Diseases; Male; Postoperative Complications; Preoperative Care; Smoking; Spirometry; Tetracycline

Topics: Actinomyces; Actinomycosis; Adult; Biopsy; Bronchial Neoplasms; Cephalosporins; Dental Caries; Epilepsy; Female; Humans; Lung Diseases; Male; Middle Aged; Periostitis; Radiography; Tetracycline

Topics: Adult; Ampicillin; Aspergillus fumigatus; Drug Synergism; Erythromycin; Humans; Kidney Transplantation; Lung Diseases; Male; Minocycline; Nocardia asteroides; Nocardia Infections; Postoperative Complications; Sputum; Tetracycline; Transplantation, Homologous

Topics: Anti-Infective Agents; Asthma; Bronchiectasis; Bronchitis; Bronchopneumonia; Chloramphenicol; Drug Combinations; Enteritis; Folic Acid Antagonists; Humans; Intestinal Diseases; Lung Diseases; Microbial Sensitivity Tests; Pneumonia; Pyrimidines; Respiratory Tract Infections; Sulfamethoxazole; Tetracycline; Trimethoprim

Topics: Adult; Aged; Drug Combinations; Female; Humans; Infusions, Parenteral; Injections, Intravenous; Lung Diseases; Male; Middle Aged; Morpholines; Oleandomycin; Postoperative Complications; Tetracycline; Tetracyclines

Topics: Adult; Antibodies, Bacterial; Blood Cell Count; Child; Child, Preschool; Cold Temperature; Complement Fixation Tests; Diagnosis, Differential; Family Practice; Female; Humans; Lung Diseases; Male; Mycoplasma Infections; Prognosis; Tetracycline

Topics: Acute Disease; Aged; Bacterial Infections; Bronchitis; Bronchopneumonia; Female; Humans; Lung Diseases; Male; Middle Aged; Minocycline; Respiratory Tract Infections; Tetracycline

Topics: Adult; Antitubercular Agents; Cycloserine; Drug Combinations; Drug Resistance, Microbial; Ethionamide; Female; Humans; Lung Diseases; Male; Mycobacterium; Mycobacterium Infections; Oxytetracycline; Tetracycline

Topics: Adult; Chloramphenicol; Complement Fixation Tests; Diabetes Complications; Hemagglutination Tests; Humans; Kanamycin; Lung Diseases; Male; Melioidosis; Radiography; Tetracycline

Topics: Actinomyces; Actinomycosis; Humans; Lung Diseases; Male; Middle Aged; Penicillins; Pleural Diseases; Tetracycline; Thoracic Diseases

Topics: Aged; Anti-Bacterial Agents; Cephalothin; Chloramphenicol; Humans; Lung Abscess; Lung Diseases; Male; Middle Aged; Penicillins; Streptomycin; Suppuration; Tetracycline

Topics: Adult; Aged; Aniline Compounds; Bronchial Diseases; Expectorants; Female; Humans; Lung Diseases; Male; Middle Aged; Quaternary Ammonium Compounds; Tetracycline; Toluene

Topics: Adolescent; Adult; Age Factors; Aged; Bronchi; Child; Chloramphenicol; Drainage; Empyema; Erythromycin; Female; Hospitalization; Humans; Lung Diseases; Male; Middle Aged; Missouri; Penicillins; Pleural Effusion; Sepsis; Sputum; Streptomycin; Tetracycline

Topics: Acute Disease; Adult; Chronic Disease; Diagnosis, Differential; Humans; Lung Diseases; Male; Melioidosis; Military Medicine; Osteoarthropathy, Secondary Hypertrophic; Pseudomonas; Tetracycline; Vietnam

Topics: Adult; Aged; Doxycycline; Drug Interactions; Humans; Iron; Lung Diseases; Middle Aged; Oxytetracycline; Tetracycline

Topics: Adult; Aged; Erythromycin; Female; Humans; Lung Diseases; Lung Diseases, Obstructive; Male; Middle Aged; Respiratory Tract Infections; Sulfamethoxypyridazine; Tetracycline

Topics: Acute Disease; Adult; Aged; Female; Guaifenesin; Humans; Lobeline; Lung Diseases; Male; Middle Aged; Respiratory Tract Infections; Tetracycline

Topics: Carbon Dioxide; Humans; Hydrogen-Ion Concentration; Hypoxia; Lung Diseases; Lung Diseases, Obstructive; Oxygen; Tetracycline

Topics: Ampicillin; Anemia, Aplastic; Child, Preschool; Chloramphenicol; Chronic Disease; Drug Hypersensitivity; Fanconi Syndrome; Female; Haemophilus influenzae; Humans; Infant; Infant, Newborn; Lung Diseases; Penicillin Resistance; Pregnancy; Seizures; Streptococcus pneumoniae; Tetracycline; Tooth Discoloration

Topics: Adolescent; Adult; Aged; Glycolates; Guaiacol; Humans; Lung Diseases; Middle Aged; Respiratory Tract Infections; Tetracycline

Topics: Abdomen; Adolescent; Adult; Aged; Anti-Bacterial Agents; Bronchiectasis; Child; Cholecystitis; Female; Humans; Injections, Intravenous; Lung Abscess; Lung Diseases; Male; Middle Aged; Morpholines; Myocarditis; Oleandomycin; Osteomyelitis; Pancreatitis; Peritonitis; Pneumonia; Tetracycline; Thoracic Surgery; Thorax

Topics: Aerosols; Animals; Depression, Chemical; Enterobacter; Kidney; Klebsiella Infections; Liver; Lung; Lung Diseases; Mice; Oleandomycin; Staphylococcal Infections; Tetracycline

Topics: Adult; Chloramphenicol; Female; Humans; Leptospirosis; Lung Diseases; Male; Melioidosis; Penicillins; Radiography; Serologic Tests; Streptomycin; Tetracycline

Topics: Adult; Aged; Bronchial Diseases; Humans; Lung Diseases; Male; Middle Aged; Pleural Diseases; Respiratory Tract Diseases; Salts; Tetracycline

Topics: Bronchial Diseases; Chloramphenicol; Humans; Lung Diseases; Microbial Sensitivity Tests; Pseudomonas Infections; Rifampin; Staphylococcal Infections; Streptococcal Infections; Tetracycline

Topics: Adult; Aged; Diagnosis, Differential; Female; Fluorescence; Humans; Lung Diseases; Lung Neoplasms; Male; Middle Aged; Stomach Diseases; Stomach Neoplasms; Tetracycline

Topics: Adult; Amphotericin B; Bacteriological Techniques; Biopsy; Brain Abscess; Cerebrospinal Fluid Proteins; Hemiplegia; Humans; Isoniazid; Joint Diseases; Lung Diseases; Male; Meningitis; Nocardia Infections; Polymyxins; Prednisone; Pseudomonas Infections; Sarcoidosis; Skin Diseases; Sporotrichosis; Tetracycline

Topics: Adult; Aged; Chronic Disease; Drug Resistance, Microbial; Female; Follow-Up Studies; Humans; Infant; Lung Diseases; Lung Neoplasms; Male; Middle Aged; Pneumococcal Infections; Prospective Studies; Serotyping; Streptococcus pneumoniae; Tetracycline

Topics: Adult; Aged; Animals; Bites and Stings; Child; Child, Preschool; Chloramphenicol; Disease Reservoirs; Erythromycin; Female; Humans; Lung Diseases; Male; Middle Aged; Osteomyelitis; Pasteurella Infections; Penicillin G; Penicillin V; Penicillins; Tetracycline; Ulcer; Wound Infection; Zoonoses

Topics: Adolescent; Adult; Aged; Amphotericin B; Female; Humans; Lung Diseases; Male; Middle Aged; Tetracycline

Topics: Bronchitis; Codeine; Guaiacol; Humans; Lobeline; Lung Diseases; Suppuration; Tetracycline

Topics: Adult; Asia, Southeastern; Chronic Disease; Diagnosis, Differential; Humans; Lung Diseases; Male; Melioidosis; Military Medicine; Pseudomonas; Respiratory Tract Infections; Tetracycline; Tuberculosis, Pulmonary; Urticaria

Topics: Blood Sedimentation; Body Weight; Child; Child, Preschool; Cystic Fibrosis; Female; Humans; Infant; Infant, Newborn; Leukocyte Count; Lung Diseases; Male; Pulmonary Fibrosis; Staphylococcal Infections; Staphylococcus; Tetracycline

Topics: Animals; Asthenia; Chlamydia; Columbidae; Communicable Diseases; Complement Fixation Tests; Cough; France; Humans; Lung Diseases; Lymph Nodes; Pneumonia, Viral; Psittacosis; Radiography, Thoracic; Tetracycline; Tomography

Topics: Adrenal Cortex Hormones; Aged; Bronchitis; Central Nervous System Stimulants; Chloramphenicol; Chronic Disease; Female; Hospitals, Special; Humans; Lung Diseases; Male; Middle Aged; Streptomycin; Tetracycline; Theophylline

Topics: Air; Animals; Germ-Free Life; Lung Diseases; Oxygen; Rats; Species Specificity; Tetracycline; Time Factors

Topics: Amphotericin B; Ampicillin; Anti-Bacterial Agents; Bronchial Diseases; Humans; Influenza, Human; Kanamycin; Lung Diseases; Methicillin; Novobiocin; Oleandomycin; Tetracycline

Topics: Adult; Aged; Female; Genital Diseases, Male; Humans; Lactobacillus; Lung Diseases; Male; Middle Aged; Tetracycline; Urologic Diseases

Topics: Actinomyces; Actinomycosis; Actinomycosis, Cervicofacial; Adolescent; Adult; Aged; Female; Humans; Lung Diseases; Male; Middle Aged; Mycetoma; Peritoneal Diseases; Tetracycline

Topics: Anti-Bacterial Agents; Arteriosclerosis; Cardiac Surgical Procedures; Cross Infection; Humans; Intestinal Diseases; Lung Diseases; Postoperative Complications; Staphylococcal Infections; Streptomycin; Surgical Wound Infection; Tetracycline; Vascular Surgical Procedures

Topics: Anti-Inflammatory Agents; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Lung Diseases; Otorhinolaryngologic Diseases; Oxadiazoles; Pediatrics; Tetracycline

Topics: Adolescent; Bronchial Neoplasms; Bronchiectasis; Cysts; Diagnosis, Differential; Fluorescence; Fluoroscopy; Gastric Lavage; Humans; Lung Abscess; Lung Diseases; Male; Mediastinal Neoplasms; Pneumothorax; Sputum; Tetracycline; Tuberculosis, Pulmonary

Topics: Adult; Ascorbic Acid; Chronic Disease; Escherichia coli Infections; Female; Humans; Infections; Lung Diseases; Male; Middle Aged; Osteomyelitis; Peritonitis; Pleural Diseases; Pneumonia; Staphylococcal Infections; Streptococcal Infections; Suppuration; Surgical Wound Infection; Tetracycline; Thiamine

Topics: Adult; Bronchiectasis; Female; Humans; Lung Diseases; Lymecycline; Male; Middle Aged; Pneumococcal Infections; Respiratory Tract Infections; Staphylococcal Infections; Tetracycline; Tuberculosis, Pulmonary

Topics: Adolescent; Adult; Aged; Cardiac Surgical Procedures; Child; Empyema; Esophageal Diseases; Extracorporeal Circulation; Female; Humans; Hypothermia, Induced; Inflammation; Infusions, Parenteral; Injections, Intravenous; Injections, Spinal; Lung Diseases; Male; Middle Aged; Pleura; Pleural Diseases; Postoperative Care; Suppuration; Tetracycline; Troleandomycin

Topics: Aged; Anti-Inflammatory Agents; Bronchial Diseases; Chronic Disease; Female; Humans; Lung Diseases; Male; Middle Aged; Tetracycline

Topics: Anti-Bacterial Agents; Child, Preschool; Female; Heart Diseases; Humans; Infant; Infant, Newborn; Infections; Lung Diseases; Male; Tetracycline; Yeasts

Topics: Anesthesia, Endotracheal; Humans; Lung Diseases; Male; Middle Aged; Pseudomonas aeruginosa; Pseudomonas Infections; Tetracycline

Topics: Adult; Ampicillin; Erythromycin; Humans; Lung Diseases; Male; Nocardia Infections; Penicillins; Radiography, Thoracic; Sepsis; Streptomycin; Sulfadiazine; Tetracycline

Topics: Fluorescence; Humans; In Vitro Techniques; Lung Diseases; Tetracycline

Topics: Aspergillosis; Bronchiectasis; Bronchitis; Bronchopneumonia; Cysts; Humans; Lung Abscess; Lung Diseases; Lung Neoplasms; Methacycline; Tetracycline

Topics: Adult; Aged; Erythromycin; Female; Humans; Lung Diseases; Male; Middle Aged; Muramidase; Tetracycline

Topics: Bronchial Neoplasms; Carcinoma, Bronchogenic; Cytodiagnosis; Humans; Lung Diseases; Lung Neoplasms; Microscopy, Fluorescence; Pleural Effusion; Tetracycline

Topics: Carcinoma; Carcinoma, Bronchogenic; Clinical Laboratory Techniques; Fluorescence; Humans; Lung Diseases; Microscopy; Microscopy, Fluorescence; Neoplasms; Sputum; Tetracycline; Ultraviolet Rays

Topics: Actinomycosis; Anti-Bacterial Agents; Clinical Laboratory Techniques; Diagnosis, Differential; Drug Therapy; Humans; Isoniazid; Lung Diseases; Lung Diseases, Fungal; Nocardia Infections; Penicillins; Pneumonectomy; Radiography, Thoracic; Streptomycin; Tetracycline

Topics: Anti-Bacterial Agents; Biomedical Research; Drug Therapy; Lung Diseases; Lymecycline; Lysine; Metabolism; Protein Synthesis Inhibitors; Rats; Tetracycline

Topics: Adult; Child, Preschool; Female; Humans; Lung Diseases; Male; Middle Aged; Tetracycline

Topics: Acetylcysteine; Adolescent; Adult; Aged; Bronchial Diseases; Female; Heart Diseases; Humans; Lung Diseases; Lymecycline; Male; Middle Aged; Tetracycline

Topics: Antitussive Agents; Bronchial Diseases; Bronchitis; Bronchopneumonia; Hemopneumothorax; Humans; Influenza, Human; Lung Diseases; Oxadiazoles; Pleurisy; Pneumonia; Pneumonia, Viral; Respiratory Tract Infections; Tetracycline

Topics: Adrenal Cortex Hormones; Aerosols; Anticoagulants; Bronchitis; Chlorothiazide; Digitalis; Digitalis Glycosides; Erythromycin; Humans; Hypertension, Pulmonary; Lung Diseases; Oxygen Inhalation Therapy; Pulmonary Emphysema; Pulmonary Heart Disease; Spiramycin; Tetracycline

Topics: Adolescent; Anti-Bacterial Agents; Child; Humans; Infectious Mononucleosis; Lung Diseases; Penicillins; Protein Synthesis Inhibitors; Pulmonary Atelectasis; Sulfonamides; Tetracycline

Topics: Drug Hypersensitivity; Dyspnea; Eosinophilia; Fever; Humans; Lung Diseases; Nitrofurantoin; Pleural Effusion; Radiography, Thoracic; Tetracycline; Toxicology; Urinary Tract Infections

Topics: Anti-Bacterial Agents; Bacteriological Techniques; Biomedical Research; Candidiasis; Incidence; Lung Diseases; Penicillins; Specimen Handling; Sputum; Streptomycin; Tetracycline

Topics: Actinomycosis; Anti-Bacterial Agents; Diagnosis, Differential; Humans; Iodine; Lung Diseases; Lung Diseases, Fungal; Penicillin V; Penicillins; Radiography, Thoracic; Sulfonamides; Tetracycline; Tuberculosis; Tuberculosis, Pulmonary

Topics: Abscess; Animals; Anti-Bacterial Agents; Bronchitis; Cross Infection; Diabetes Mellitus; Erythromycin; Furunculosis; Fusidic Acid; Gangrene; Humans; Leukemia; Lung Diseases; Penicillins; Pyelonephritis; Sepsis; Staphylococcal Infections; Streptomycin; Sulfonamides; Tetracycline

Topics: Aerosols; Anti-Bacterial Agents; Antifungal Agents; Aspergillosis; Bronchial Diseases; Candidiasis; Classification; Diagnosis, Differential; Humans; Lung Diseases; Lung Diseases, Fungal; Mycoses; Natamycin; Statistics as Topic; Tetracycline

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Bronchial Diseases; Candidiasis; Diarrhea; Lung Diseases; Nausea; Nystatin; Tetracycline; Toxicology; Vomiting

Topics: Anti-Bacterial Agents; Drug Therapy; Erythromycin; Humans; Lung Diseases; Lung Diseases, Fungal; Penicillins; Pneumonia; Pneumonia, Pneumococcal; Pneumonia, Rickettsial; Pneumonia, Viral; Streptomycin; Tetracycline; Tuberculosis

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Bronchitis; Geriatrics; Lung Diseases; Protein Synthesis Inhibitors; Tetracycline

Topics: Bronchial Diseases; Glycerol; Humans; Lung Diseases; Protein Synthesis Inhibitors; Respiratory Tract Infections; Tetracycline

Topics: Anti-Bacterial Agents; Canada; Chloramphenicol; Cortisone; Erythromycin; Geriatrics; Humans; Leukemia; Leukemia, Lymphoid; Lung Diseases; Lung Diseases, Fungal; Mucormycosis; Pathology; Prednisone; Tetracycline; Zygomycosis

Topics: Bronchiectasis; Bronchitis; Carcinoma, Bronchogenic; Fluorescence; Humans; Lung Diseases; Neoplasms; Oxytetracycline; Pulmonary Emphysema; Tetracycline

Topics: Aerosols; Anti-Bacterial Agents; Humans; Lung Diseases; Respiratory Therapy; Tetracycline; Toxicology; Turpentine

Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Bronchography; Bronchopneumonia; Chloramphenicol; Diatomaceous Earth; Leukocytosis; Lung Diseases; Oleandomycin; Penicillins; Radiography, Thoracic; Rolitetracycline; Silicosis; Streptomycin; Tetracycline; Tomography

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Bacteriology; Bronchi; Bronchial Diseases; Bronchoscopy; Chloramphenicol; Erythromycin; Lung Diseases; Novobiocin; Oleandomycin; Oxytetracycline; Penicillins; Protein Synthesis Inhibitors; Spiramycin; Sputum; Streptomycin; Tetracycline

Topics: Anti-Bacterial Agents; Biomedical Research; Bronchi; Bronchial Neoplasms; Bronchitis; Chloramphenicol; Drug Resistance; Drug Resistance, Microbial; Haemophilus influenzae; Humans; Lung Diseases; Lung Neoplasms; Neisseria; Pneumococcal Infections; Respiratory Tract Infections; Sputum; Streptomycin; Sulfonamides; Tetracycline

Topics: Bronchiectasis; Humans; Lung Diseases; Penicillin V; Penicillins; Pulmonary Medicine; Respiratory Tract Infections; Suppuration; Tetracycline; Tetracyclines

Topics: Humans; Lung Abscess; Lung Diseases; Oleandomycin; Prednisolone; Tetracycline

Topics: Child; Drug Combinations; Infant; Lung Diseases; Sulfadiazine; Sulfamerazine; Sulfamethazine; Sulfonamides; Tetracycline

Topics: Anti-Bacterial Agents; Bronchiectasis; Humans; Lung Diseases; Oleandomycin; Tetracycline

Topics: Anti-Bacterial Agents; Chloramphenicol; Lung Diseases; Meningoencephalitis; Protein Synthesis Inhibitors; Sepsis; Tetracycline

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Lung Diseases; Oleandomycin; Respiratory Tract Infections; Tetracycline

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Dermatologic Agents; Humans; Lung Diseases; Nystatin; Protein Synthesis Inhibitors; Tetracycline

Topics: Bacteremia; Erythromycin; Escherichia coli; Escherichia coli Infections; Infections; Lung Diseases; Micrococcus; Sepsis; Tetracycline

Topics: Anti-Bacterial Agents; Lung Diseases; Micrococcus; Pneumonia; Tetracycline; Urinary Tract Infections