tetracycline and Liver-Diseases

Application of nuclear medicine for gastroenterology, especially the liver, portal circulation and alimentary tract was described. In the liver, radiocolloid scintigraphy is useful for the diagnosis and follow-up study of chronic liver diseases. 99mTc-GSA scintigraphy plays a role for the evaluation of hepatic functional reserve. 99mTc-PMT used for hepatobiliary imaging, is also useful for the diagnosis of hepatic tumor and extra-hepatic metastasis of hepatocellular carcinoma. In the study of portal circulation, various administration sites such as intrasplenic, rectal, oral, and intravenous have been reported. In the evaluation of motility function of alimentary tract, estimation of gastric emptying time is well known. Condensed image created from serial esophageal scintigrams using computer processing is also useful for the quantitative and qualitative evaluation of esophageal motility function and gastro-esophageal reflux. Abdominal scintigraphy with 99mTc-human serum albumin enables imaging diagnosis of protein-loosing gastroenteropathy.

Topics: Digestive System; Gastrointestinal Diseases; Humans; Image Processing, Computer-Assisted; Liver; Liver Diseases; Organotechnetium Compounds; Portal System; Protein-Losing Enteropathies; Pyrrolidines; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Aggregated Albumin; Technetium Tc 99m Pentetate; Tetracycline

Topics: Ampicillin; Antitubercular Agents; Asparaginase; Chemical and Drug Induced Liver Injury; Chloramphenicol; Chlortetracycline; Erythromycin; Griseofulvin; Humans; Liver Diseases; Methicillin; Oleandomycin; Oxytetracycline; Penicillins; Rifampin; Tetracycline

Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Fatty Liver; Granuloma; Hemorrhagic Disorders; Humans; Liver; Liver Diseases; Pharmaceutical Preparations; Tetracycline

Topics: Animals; Arsenicals; Chemical and Drug Induced Liver Injury; Chloroform; Chlorpromazine; Contraceptives, Oral; Drug Hypersensitivity; Humans; Isoniazid; Liver Diseases; Steroids; Tannins; Tetracycline

Topics: Anti-Bacterial Agents; Bone and Bones; Chlortetracycline; Demeclocycline; Gastroenterology; Liver Diseases; Metabolism; Nitrogen; Oxytetracycline; Photosensitivity Disorders; Protein Synthesis Inhibitors; Tetracycline; Tooth; Toxicology

Topics: Chloramphenicol; Clinical Trials as Topic; Hematopoietic System; Humans; Kidney Diseases; Liver Diseases; Tetracycline

The study reports the phenolic composition of propolis from Bangladesh and its ameliorative effects against tetracycline-induced hepatonephrotoxicity in rats. Male Wistar Albino rats (n = 18) were randomly divided into three following groups: (1) normal control, (2) tetracycline-treatment (200 mg kg

Topics: Animals; Bangladesh; Bees; Bilirubin; Humans; Kidney Diseases; Lipids; Liver; Liver Diseases; Liver Function Tests; Male; Oxidative Stress; Propolis; Rats; Rats, Wistar; Tetracycline

The prevalence of hepatic cysts is 0.1% to 0.5% based on autopsy studies, and 2.5% based on US examinations. Percutaneous therapies are a new alternative to surgery. They include simple percutaneous aspiration, catheter drainage alone, and catheter drainage with sclerotherapy. We present an 11-year-old boy admitted to hospital because of abdominal pain. A diagnosis of simple hepatic cyst was made, which was treated with aspiration and tetracycline hydrochloride solution (5%) injection into the cystic cavity. Complete regression was seen on US and MRI examination at 3 months, with total collapse and deflation of the cyst. The cyst regressed totally, leaving a hyperechoic linear scar on US examination at 1 year. On the basis of the clinical and imaging results obtained, percutaneous sclerotherapy of hepatic cysts can be recommended as the treatment of choice and as a valid alternative to laparoscopy in children.

Topics: Child; Cysts; Humans; Injections, Intralesional; Liver Diseases; Male; Sclerosing Solutions; Sclerotherapy; Tetracycline; Treatment Outcome

This paper reports two cases of benign hepatic cysts successfully treated by the instillation of tetracycline hydrochloride. The patients presented with solitary large symptomatic hepatic cysts and underwent ultrasound guided needle aspiration followed by the instillation of tetracycline hydrochloride. The cyst size diminished without complication and the patients have remained symptom free. We review the treatment of this uncommon entity and propose that injection of tetracycline hydrochloride is an effective nonoperative treatment of symptomatic solitary hepatic cysts.

Topics: Adolescent; Aged; Aged, 80 and over; Anti-Bacterial Agents; Cysts; Drainage; Humans; Instillation, Drug; Liver Diseases; Male; Sclerotherapy; Tetracycline; Ultrasonography

We report the case of an 84-year-old woman with abdominal pain, distension and inferior veno-caval compression due to a large non-parasitic hepatic cyst. She was treated by instillation of tetracycline hydrochloride into the hepatic cyst. Six months after treatment, the patient is asymptomatic, with no reaccumulation of the hepatic cyst. We conclude that symptomatic hepatic cysts may be successfully treated by tetracycline hydrochloride instillation sclerosis.

Topics: Aged; Aged, 80 and over; Cysts; Female; Humans; Instillation, Drug; Liver Diseases; Sclerosing Solutions; Sclerotherapy; Tetracycline

Psittacosis marked by liver and spleen involvement and minimal pericarditis was observed in an 18-year-old patient hospitalized for fever of 1 month duration. At admission, there was no other clinical manifestation and the chest X-ray showed no sign of pulmonary involvement. Liver tests revealed cholestasis. Ultrasonography of the abdomen revealed multiple nodular formations in the liver and spleen, images confirmed on computed tomography. Liver biopsy showed granulomatous with hyperplasia of the Kupffer cells surrounded by healthy tissue. Complement fixation to psittacosis antigen was positive and increased significantly over a 15-day interval. Treatment with tetracycline led to rapid remission of the fever and normalization of the liver tests and hepatic images. Liver involvement in psittacosis is not uncommon, but this is apparently the first case reporting echographic anomalies. The absence of pulmonary involvement has been reported earlier in a few cases. The diagnosis is usually suggested on the basis of epidemiologic criteria and confirmed by complement fixation.

Topics: Adolescent; Anti-Bacterial Agents; Humans; Liver Diseases; Male; Psittacosis; Tetracycline; Ultrasonography

Polycystic liver disease is a relatively uncommon congenital condition. Infections of these cysts do occur, but there are no reports of salmonella as the aetiologic agent. Salmonellosis, complicating hydatid disease of the liver has been described.. A patient with a long-standing polycystic liver disease suddenly developed an infection of one of the cysts, caused by Salmonella javiana. Under sonographic guidance a percutaneous drain was inserted into the cyst, followed by systemic antibiotic treatment and, later, intracystic instillation of tetracycline.. The sclerosing treatment was successful, thus preventing laparotomy.

Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Cysts; Female; Humans; Liver Diseases; Salmonella Infections; Sclerotherapy; Tetracycline

Administration of tetracycline was believed to be associated with an adverse drug reaction in a cat. Clinical signs consisted of anorexia, ptyalism, and signs of depression. The most noticeable biochemical abnormality was a markedly high serum alanine transaminase activity. Treatment consisted of vitamin E and selenium injections and feeding via a gastrostomy tube. Abnormalities noticed on histologic examination of hepatic tissue were centrilobular fibrosis, mild diffuse cholangiohepatitis, and mild hepatic lipidosis. The lipidosis was believed to have resulted from tetracycline administration, whereas the more chronic lesions (hepatic fibrosis and mild cholangiohepatitis) were believed to have resulted from preexisting, subclinical hepatic disease. Because serum alanine transaminase activity returned to reference ranges and the anorexia and ptyalism resolved with cessation of tetracycline administration, these abnormalities were believed to have represented an adverse drug reaction. Treatment of the cat with vitamin E and selenium was instituted on the basis of reported preventive and therapeutic effects in albino rats with tetracycline-induced hepatic lesions. Whether these compounds had any role in accelerating clinical recovery in this cat is uncertain.

Topics: Alanine Transaminase; Animals; Cat Diseases; Cats; Chemical and Drug Induced Liver Injury; Female; Liver; Liver Diseases; Selenium; Tetracycline; Vitamin E

Susceptible rat strains develop hepatobiliary injury following the surgical creation of self-filling blind loops that cause small bowel bacterial overgrowth. Luminal bacteria or their cell wall polymers were implicated in the pathogenesis of the lesions because sham-operated rats and rats with self-emptying blind loops, having only slightly increased bacterial counts, did not develop hepatic injury. In this study, antibiotics with different spectra of activities were continuously administered starting 1 day or 22 days after surgery to determine which intestinal flora may be responsible for the development of hepatic injury in rats with small bowel bacterial overgrowth. Four weeks following surgery, Lewis rats with self-filling blind loops receiving no antibiotics had elevated liver histology scores (8.2 +/- 1.3 vs. 0.7 +/- 0.4) and plasma aspartate aminotransferase levels (269 +/- 171 vs. 84 +/- 24) compared with sham-operated rats, P less than 0.001. Oral gentamicin as well as oral and intraperitoneal polymyxin B, which binds endotoxin, did not prevent hepatic injury in rats with self-filling blind loops. However, oral metronidazole and tetracycline therapy continuously administered beginning 1 day after surgery diminished hepatic injury (histology score 3.0 +/- 1.8, 2.9 +/- 1.1; aspartate aminotransferase 87 +/- 25, 98 +/- 34; respectively P less than 0.001 compared with self-filling blind loops receiving no antibiotics). Metronidazole also protected Wistar rats that require 12 weeks to develop hepatic injury following experimentally induced small bowel bacterial overgrowth compared with rats with self-filling blind loops that received no antibiotic treatment (histology score 10.4 +/- 1.3 vs. 0.7 +/- 1.1, and aspartate aminotransferase 273 +/- 239 vs. 76 +/- 20, P less than 0.001). When rats started metronidazole therapy 22 days after self-filling blind loop surgery, elevated aspartate aminotransferase values decreased to normal during the next 77 days and final histology scores were normal. All rats with self-filling blind loops had negative peritoneal, liver, spleen, and blood cultures but approximately 75% of mesenteric lymph node cultures were positive irrespective of antibiotic treatment. Because Bacteroides species have been implicated in causing vitamin B12 and disaccharidase deficiencies in rats with self-filling blind loops, we documented the presence or absence of these organisms from blind loops using selective culture techniques. Metronidazo

Topics: Animals; Bacteria; Bacterial Infections; Colony Count, Microbial; Female; Gentamicins; Hepatomegaly; Intestine, Small; Jejunum; Liver; Liver Diseases; Liver Function Tests; Male; Metronidazole; Polymyxin B; Rats; Rats, Inbred Lew; Rats, Inbred Strains; Tetracycline

Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cholagogues and Choleretics; Drug Evaluation, Preclinical; Flavonoids; Liver; Liver Diseases; Male; Rats; Tetracycline

It was shown in the experiments with albino rats that legalon and essentiale had a pronounced hepatoprotective effect in tetracycline affections of the liver. They retarded the increase in the activity of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase in blood serum, prevented suppression of cholopoiesis by tetracycline and inhibited lipid peroxidation. The drugs may be used for prevention and treatment of tetracycline affections of the liver.

Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclinical; Drug Therapy, Combination; Flavonoids; Liver Diseases; Male; Phosphatidylcholines; Plants, Medicinal; Rats; Silymarin; Tetracycline

The seasonal characteristic features of the efficacy of antioxidants in tetracycline affections of the liver were revealed in the experiments with 182 noninbred albino male rats. It was shown that sodium selenite had the most pronounced hepatoprotective effect in autumn and winter, while vitamin E was most effective in spring and summer. The combination of sodium selenite with vitamin E recovered impaired bile excretion in autumn, spring and summer. In winter, the recovery was less effective. It is concluded that the time factor plays a significant role in tetracycline hepatotoxicity and efficacy of antioxidants in tetracycline affections of the liver.

Topics: Animals; Antioxidants; Bile; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclinical; Drug Therapy, Combination; Liver Diseases; Male; Rats; Seasons; Selenious Acid; Selenium; Tetracycline; Time Factors; Vitamin E

Studies on albino rats showed that high doses of tetracycline-induced damages of the liver evident from increased activity of serum enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase) and inhibition of bile secretion, synthesis and secretion of bile acids and cholesterol excretion. Administration of vitamin E, sodium selenite, infusion of Astragalus L. and especially vitamin E combinations with sodium selenite markedly or completely arrested the occurrence of hepatotoxic properties of tetracycline. It is suggested that the use of vitamin E combinations with selenium-containing preparations is advisable in the prophylaxis and treatment of tetracycline-induced damages of the liver.

Topics: Animals; Bile; Chemical and Drug Induced Liver Injury; Chlortetracycline; Drug Evaluation, Preclinical; Liver; Liver Diseases; Male; Plant Extracts; Rats; Selenious Acid; Selenium; Tetracycline; Vitamin E

It was shown on pubertal albino rats that the intensity of excretion with the bile of radioactive Bengal rose was different at different seasons: the maximum and minimum levels were observed in winter and summer, respectively. When the liver was affected with tetracycline, this process was suppressed especially in summer. The use of antioxidants, such as tocopherol acetate in combination with sodium selenite promoted the recovery of liver excretion function in winter, spring and autumn. In summer, the recovery was only partial.

Topics: Animals; Bile; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; Male; Rats; Rose Bengal; Seasons; Selenious Acid; Selenium; Tetracycline; Vitamin E

Administration of antibiotics has been reported to prevent or minimize liver dysfunction in experimental animals having been subjected to jejunoileal bypass, suggesting that jejunoileal bypass-induced liver dysfunction results from production of toxic substances by bacteria in the defunctionalized bowel. However, improved absorption will also prevent bypass-induced liver injury. We studied the effects of tetracycline on the development of bypass-induced liver dysfunction and compared it to the mucosal adaptation of the intact bowel after bypass. After 6 weeks, rats subjected to bypass but not given antibiotics had decreased levels of serum triglycerides, hepatic cytochrome P-450, and hepatic pentobarbital hydroxylase. Evaluation of intestinal mucosal hyperplasia after bypass indicated that animals given antibiotics after bypass developed greater increases in mucosal DNA content, mucosal protein, and mucosal weight than bypassed animals not receiving antibiotics. We speculate that the beneficial effects of antibiotic administration on liver function after bypass may be a result of improved absorption.

Topics: Animals; Cytochrome P-450 Enzyme System; Ileum; Jejunum; Liver Diseases; Male; Microsomes, Liver; Mixed Function Oxygenases; Obesity; Pentobarbital; Postoperative Complications; Premedication; Rats; Rats, Inbred Strains; Tetracycline; Triglycerides

Two patients with Q fever endocarditis are described. Both patients demonstrated some of the characteristic features of Q fever endocarditis, i.e. the long course of the disease before diagnosis, persistently negative blood cultures, resistance to conventional antibiotic therapy and a dramatic response to tetracycline therapy. Complications included arteriovenous thrombo-embolism and hepatic enlargement, and 1 patient developed an immune complex form of glomerulonephritis. The possibility of Q fever endocarditis should be considered in all patients with infective endocarditis in whom blood cultures are negative and who fail to respond to conventional antibiotic therapy.

Topics: Adult; Endocarditis, Bacterial; Female; Glomerulonephritis; Humans; Liver Diseases; Male; Q Fever; Tetracycline

Sixteen cases of chronic Q fever are described. In eight there was a history of exposure to infection from farms or farm products. All had valvular heart disease, involving the mitral valve in nine and the aortic valve in seven. Infection occurred on a prosthetic valve in two patients. Arterial embolism was common. Venous thrombosis occured in three patients, and pulmonary embolism occurred in three other patients. Complement fixing antibodies to phase 1 antigen were found in a titre of 1:200 or greater in all except two patients. In one of these post-mortem examination revealed rickettsial bodies in mitral valve vegetations, and in the other Coxiella burneti was isolated from heart valve tissue. The majority presented with infective endocarditis but two presented primarily with liver disease. All patients had evidence of liver involvement and in one this led to death from cirrhosis. Abnormal tests of liver function, particularly hyperglobulinaemia, raised alkaline phsophatase and abnormal bromsulphthalein retention were found in all patients. Hepatic histology was abnormal in all eight patients in whom it was studied. The commonest features were mononuclear cell infiltration of the portal tracts and prominence of the sinusoidal Kupffer cells. Patchy focal necrosis of parenchymal cells, granulomata, fatty change, and eosinophilia of the sinusoidal walls were also noted in several patients and cirrhosis developed in one. Six patients had a purpuric rash, and in 12 there was thrombocytopenia. It is suggested that the presence of hepatomegaly and liver involvement and thrombocytopenia may help to differentiate Q fever endocarditis from bacterial endocarditis. Raised serum IgM and IgA levels occured frequently, but with only a moderate dominance of IgM. Sheep cell agglutination and latex fixation tests for rheumatoid factor were occasionally positive. Several features of the disease suggest the possibility that immune-complex mechanisms may play a role in chronic Q fever. Treatment was with prolonged courses of tetracycline usually combined with lincomycin. Seven patients underwent valve replacement surgery for haemodynamic reasons. Five patients died; two from heart failure, one from cirrhosis, one seven days after valve replacement and one from intraperitoneal haemorrhage following percutaneous liver biopsy. Three patients have survived for more than five years, and another six for more than three and a half years after diagnosis. Of these nine patients, th

Topics: Adult; Chronic Disease; Endocarditis; Female; Heart Valve Diseases; Hematologic Diseases; Humans; Hypergammaglobulinemia; Lincomycin; Liver Diseases; Male; Middle Aged; Q Fever; Tetracycline; Thrombocytopenia

A large number of chemical agents, administered for therapeutic or diagnostic purposes, can produce various types of hepatic injury by several mechanisms. Some agents are intrinsically hepatotoxic, and others produce hepatic injury only in the rare, uniquely susceptible individual. Idiosyncrasy of the host is the mechanism for most types of drug-induced hepatic injury. It may reflect allergy to the drug or a metabolic aberation of the host permitting the accumulation of hepatotoxic metabolites. The syndromes of hepatic disease produced by drugs have been classified hepatocellular, hepatocanalicular, mixed and canalicular. Measurement of serum enzyme activities has provided a powerful tool for studies of hepatotoxicity. Their measurement requires awareness of relative specificity, knowledge of the mechanisms involved, and knowledge of the relationship between known hepatotoxic states and elevated enzyme activities.

Topics: Anti-Bacterial Agents; Anticonvulsants; Antidepressive Agents; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Contraceptives, Oral, Hormonal; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Ethanol; Female; Humans; Liver Diseases; Mitochondria, Liver; Rifampin; Steroids; Tetracycline; Tranquilizing Agents

Philosophic concepts and pragmatic approaches toward improved understanding of the effect of drugs in the hepatocyte are reviewed. No set pattern of studies is advocated but rather observations are encouraged within the framework of studies that provide for varied exposure of the hepatocyte. Clinical usage should be imitated to provide earliest possible indications of toxicity in man. The need for definitive characterization through utilization of appropriate methodology derived from cross-fertilization of related disciplines is stressed. Both minimal and maximal dose effects should be established. Selected use of electron microscopy has become essential for characterizing responses of the liver to injury. The advantages of the toluidine blue-stained Epon "thick" sections are emphasized. Such observations are used to implement the utility of serial biopsies from the beagle dog prior to and during long-term study of potential hepatic injury. Examples of the critical effects of drug concentration within the hepatocyte are presented.

Topics: Animals; Chemical and Drug Induced Liver Injury; Dogs; Female; Humans; Liver; Liver Diseases; Microscopy, Electron; Rats; Tetracycline

Topics: Acute Kidney Injury; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Hypoglycemia; Liver Diseases; Male; Middle Aged; Military Medicine; Tetracycline; United States

Topics: Adult; Aminoglycosides; Anti-Bacterial Agents; Anti-Infective Agents; Biotransformation; Blood Proteins; Cephalosporins; Half-Life; Humans; Kidney Failure, Chronic; Kidney Function Tests; Liver Diseases; Models, Biological; Penicillins; Protein Binding; Renal Dialysis; Tetracycline

Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Female; Hepatitis A; Humans; Liver Diseases; Male; Recurrence; Tetracycline

Topics: Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Cholestasis; Contraceptives, Oral; Fatty Liver; Female; Halothane; Hepatitis A; Humans; Jaundice; Jaundice, Chronic Idiopathic; Liver; Liver Cirrhosis; Liver Diseases; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Rupture, Spontaneous; Tetracycline

Topics: Cholestasis; Fatty Liver; Female; Halothane; Hepatitis; Hepatitis A; Hepatitis B; Hepatitis B Antigens; Humans; Hysterectomy; Liver Diseases; Liver Function Tests; Liver Regeneration; Maternal Mortality; Methoxyflurane; Middle Aged; Postoperative Complications; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Tetracycline; Transfusion Reaction

Topics: Amphotericin B; Ampicillin; Animals; Anti-Bacterial Agents; Azaguanine; Cephaloridine; Chloramphenicol; Colistin; Cyclophosphamide; Cycloserine; Erythromycin; Female; Kanamycin; Liver Diseases; Mice; Mitomycins; Penicillins; Polymyxins; Streptomycin; Tetracycline; Viomycin

Topics: Animals; Animals, Laboratory; Bacillus; Liver Diseases; Mice; Rodent Diseases; Tetracycline

Topics: Animals; Chlorpromazine; Cysteine; Injections, Intraperitoneal; Ischemia; Liver Diseases; Necrosis; Rats; Tetracycline

Topics: Aged; Ampicillin; Hemochromatosis; Humans; Kanamycin; Liver Diseases; Male; Middle Aged; Pasteurella; Pasteurella Infections; Polycythemia Vera; Sepsis; Tetracycline

Topics: Anti-Bacterial Agents; Bile Duct Neoplasms; Bile Ducts; Biopsy; Cholangitis; Cholestasis; Colectomy; Colitis, Ulcerative; Fatty Liver; Follow-Up Studies; Hepatitis; Humans; Inflammation; Liver; Liver Cirrhosis; Liver Cirrhosis, Biliary; Liver Diseases; Liver Function Tests; Portal System; Prednisolone; Sepsis; Tetracycline

Topics: Age Factors; Anti-Bacterial Agents; Biliary Tract Diseases; Chloramphenicol; Drug Hypersensitivity; Female; Genotype; Glucosephosphate Dehydrogenase; Humans; Kanamycin; Kidney Diseases; Liver; Liver Diseases; Metabolism, Inborn Errors; Nervous System Diseases; Pregnancy; Pregnancy Complications; Streptomycin; Sulfonamides; Tetracycline

Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Aspartate Aminotransferases; Bacteroides; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Enterococcus faecalis; Female; Humans; Hyperbilirubinemia; Jaundice; Liver; Liver Diseases; Liver Function Tests; Male; Mercaptopurine; Postoperative Complications; Pseudomonas; Sepsis; Staphylococcus; Streptococcus; Tetracycline; Transfusion Reaction

Topics: Anti-Bacterial Agents; Erythromycin; Gastroenterology; Humans; Iatrogenic Disease; Infections; Intestines; Liver Diseases; Novobiocin; Nutritional Physiological Phenomena; Tetracycline

Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Liver Diseases; Male; Necrosis; Ornithine Carbamoyltransferase; Perfusion; Rats; Tetracycline

Topics: Abortion, Septic; Adult; Blood Urea Nitrogen; Bronchopneumonia; Female; Humans; Jaundice; Liver Diseases; Male; Middle Aged; Pregnancy; Pregnancy Complications; Pyelonephritis; Rectovaginal Fistula; Tetracycline; Urea

Topics: Acute Kidney Injury; Adult; Female; Fetal Death; Humans; In Vitro Techniques; Kidney; Liver Diseases; Pregnancy; Pregnancy Complications, Infectious; Proteinuria; Pyelonephritis; Tetracycline; Urine; Water-Electrolyte Balance

Topics: Anti-Bacterial Agents; Bacitracin; Bone Marrow Diseases; Drug Eruptions; Gastrointestinal Diseases; Kanamycin; Kidney Diseases; Liver Diseases; Necrosis; Neomycin; Neurologic Manifestations; Penicillins; Pharmacology; Polymyxins; Ristocetin; Streptomycin; Tetracycline; Toxicology; Vancomycin; Vestibule, Labyrinth

Topics: Fluorescence; Infarction; Ischemia; Liver Circulation; Liver Diseases; Microscopy; Microscopy, Fluorescence; Pathology; Protein Synthesis Inhibitors; Rats; Research; Tetracycline

Topics: Castration; Estrogens; Geriatrics; Humans; Kidney; Kidney Diseases; Liver Diseases; Male; Orchiectomy; Tetracycline; Toxicology

Topics: Anti-Bacterial Agents; Chloramphenicol; Ischemia; Liver Diseases; Penicillins; Rabbits; Research; Tetracycline

Topics: Gastrointestinal Hemorrhage; Hematemesis; Hematuria; Hepatitis; Hepatitis A; Humans; Liver Diseases; Melena; Nephritis; Tetracycline

Topics: Anti-Bacterial Agents; Bacitracin; Bile; Biliary Tract; Chloramphenicol; Dogs; Erythromycin; Hepatobiliary Elimination; Liver; Liver Diseases; Neomycin; Novobiocin; Oleandomycin; Penicillins; Polymyxins; Research; Rifamycins; Spiramycin; Streptomycin; Tetracycline

Topics: Chloramphenicol; Clinical Enzyme Tests; Escherichia coli Infections; Female; Humans; Jaundice; Jaundice, Obstructive; Liver Diseases; Liver Function Tests; Pancreas; Pancreatitis; Pregnancy; Pregnancy Complications; Pyelonephritis; Streptomycin; Tetracycline; Toxicology; Uremia

Topics: Acidosis; Cesarean Section; Fatty Liver; Female; Hematemesis; Humans; Hypoproteinemia; Hypotension; Hysterectomy; Jaundice; Liver Diseases; Melena; Oxytetracycline; Pathology; Placenta Previa; Pneumonia; Postpartum Hemorrhage; Postpartum Period; Pregnancy; Pregnancy Complications; Tetracycline; Toxicology

Topics: Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Hepatitis; Liver Diseases; Pathology; Pregnancy; Pregnancy Complications; Pyelonephritis; Tetracycline; Toxicology

Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Chloramphenicol; Colistin; Cortisone; Encephalitis; Erythromycin; Kanamycin; Liver Diseases; Mice; Penicillins; Pharmacology; Protein Synthesis Inhibitors; Research; Rodent Diseases; Streptomycin; Sulfonamides; Tetracycline

Topics: Abnormalities, Drug-Induced; Amelogenesis; Drug Therapy; Female; Fetal Diseases; Fetus; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Kidney Diseases; Liver Diseases; Pregnancy; Pregnancy Complications; Tetracycline; Tooth Discoloration; Toxicology

Topics: Biliary Tract; Drug Therapy; Gastrointestinal Diseases; Humans; Liver Diseases; Rifamycins; Surgical Procedures, Operative; Tetracycline

Topics: Administration, Intravenous; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Hepatitis; Histocytochemistry; Humans; Liver Diseases; Pathology; Pregnancy; Pregnancy Complications; Pyelonephritis; Research; Tetracycline

Topics: Female; Fetal Diseases; Fetus; Gastrointestinal Tract; Humans; Kidney Diseases; Liver Diseases; Maternal-Fetal Exchange; Myocarditis; Pregnancy; Pregnancy, Animal; Rabbits; Research; Tetracycline; Tetracyclines; Toxicology

Topics: Anti-Bacterial Agents; Intestinal Diseases; Liver Diseases; Lymphadenitis; Mice; Pathology; Pharmacology; Protein Synthesis Inhibitors; Research; Spleen; Tetracycline; Toxicology

Topics: Anti-Bacterial Agents; Humans; Listeria; Listeriosis; Liver Diseases; Meningitis; Serositis; Tetracycline