tetracycline and Leukopenia

Topics: Albuminuria; Anemia; Arrhythmias, Cardiac; Aspartate Aminotransferases; Chloramphenicol; Conjunctivitis; Evaluation Studies as Topic; Fever; Hepatomegaly; Humans; Hypotension, Orthostatic; Leukopenia; Lymphatic Diseases; Male; Military Medicine; Recurrence; Scrub Typhus; Skin Ulcer; Splenomegaly; Tetracycline

Although liver involvement is frequently seen in brucellosis, acute hepatitis is a rare clinical entity. In its progress, haematological findings are non-specific and vary in respect to severity. In this paper, we present a case of brucellosis with acute hepatitis and bicytopenia without anaemia. A 19-year-old man presented with a 2-week history of fever, sweating, low back and leg pain, lassitude, loss appetite, nausea and vomiting. He gave a history of raw milk ingestion and animal contact. Physical examination showed signs of icteric skin and sclera, tenderness in the right hypochondriac region and hepatosplenomegaly. On admission to hospital, laboratory tests showed WBC 3500/mmc (polymorphs 63% and lymphocytes 33%), haemoglobin 13.8 g/dL, platelet 89000/mmc, erythrocyte sedimentation rate 19 mm/h, and C-reactive protein 21.7 mg/dL (N<0.8 mg/dL). Biochemical tests were as follows: AST 771 U/L, ALT 471 U/L, ALP 355 U/L, GGT 432 U/L, total bilirubin 2.61 mg/dL, direct bilirubin 1.45 mg/dL and albumin 3.7 g/dL. Viral hepatitis markers were found to be negative (HBsAg, anti-HBc total, anti-HBc IgM, anti-HAV IgM, and anti-HCV). Blood culture grew Brucella melitensis. Leukopenia and thrombocytopenia returned to normal levels at the 7th and 14th day of his admission, respectively. Liver function tests improved at the 28th day. Treatment of the brucellosis was performed with antibiotics (tetracycline 500 mg orally four times daily for 6 weeks and streptomycin 1 g IM once daily for 21 days). Finally, a case of brucellosis with acute hepatitis and bicytopenia was treated with a successful outcome. In conclusion, we suggest that due consideration be taken of bicytopenia/pancytopenia and acute hepatitis in brucellosis cases in Turkey, an endemic region.

Topics: Acute Disease; Adult; Anti-Bacterial Agents; Brucella melitensis; Brucellosis; Drug Therapy, Combination; Hepatitis; Humans; Leukopenia; Male; Streptomycin; Tetracycline; Thrombocytopenia; Treatment Outcome; Turkey

Daily administration of 1 mg of folinic acid to immunosuppressed rats with incipient or established Pneumocystis carinii pneumonia did not impair the capacity of trimethoprim-sulfamethoxazole to either prevent or treat this disease. These observations constitute the first experimental support for the use of folinic acid to prevent or control cytopenias that occur in patients with Pneumocystis carinii pneumonia who are under trimethoprim-sulfamethoxazole treatment.

Topics: Animals; Dexamethasone; Drug Combinations; Drug Interactions; Immunosuppression Therapy; Leucovorin; Leukopenia; Male; Pneumocystis; Pneumonia, Pneumocystis; Random Allocation; Rats; Rats, Inbred Strains; Sulfamethoxazole; Tetracycline; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

The effect of some potentially myelotoxic drugs on the growth of colony-forming cells in mouse marrow in vitro was examined. Among the drugs tested chloramphenicol, thiamphenicol, and chlorpromazine were inhibitory in therapeutic concentrations, a finding consistent with the common occurrence of a dose-dependent leukopenia from these drugs. The degree of drug-induced inhibition of colony growth was inversely proportional to the concentration of colony-stimulating factor in the medium. It is postulated that the concentration of colony-stimulating factor in the cell milieu in vivo may play a significnat role in determining the occurrence or degree of leukopenia from thses drugs.

Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Division; Chloramphenicol; Chlorpromazine; Clone Cells; Dose-Response Relationship, Drug; In Vitro Techniques; Leukopenia; Mice; Phenylbutazone; Phenytoin; Tetracycline; Thiamphenicol

Eight grivet monkeys infected with Borrelia recurrentis received tetracycline (12.5mg/kg body weight) on the 3rd or 4th day of spirochetemia. Leukopenia, fever, hyperpnea, and tachycardia developed within 2 hours as spirochete counts fell to undetectable levels. These events closely simulated the crisis in human louse-borne relapsing fever in both timing and extent.

Topics: Animals; Blood; Borrelia; Disease Models, Animal; Female; Fever; Haplorhini; Heart Rate; Insect Vectors; Leukocyte Count; Leukocytes; Leukopenia; Male; Phthiraptera; Relapsing Fever; Respiration; Tachycardia; Tetracycline

Topics: Agranulocytosis; Amphotericin B; Anemia, Aplastic; Anemia, Hemolytic; Anti-Bacterial Agents; Ataxia; Bacitracin; Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Chloramphenicol; Deafness; Gastrointestinal Diseases; Gentamicins; Humans; Kanamycin; Kidney Diseases; Leukopenia; Lung Diseases; Neomycin; Neuromuscular Diseases; Nitrofurantoin; Optic Neuritis; Peripheral Nervous System Diseases; Skin Diseases; Streptomycin; Sulfonamides; Tetracycline; Thrombocytopenia; Vertigo

Topics: Acne Vulgaris; Adolescent; Blood Cell Count; Blood Cells; Blood Sedimentation; Erythrocytes; Female; Hemoglobins; Humans; Leukocyte Count; Leukopenia; Male; Reticulocytes; Tetracycline

Topics: Animals; Animals, Newborn; Bacteria; Corynebacterium; Cricetinae; Diarrhea; Enterobacter; Escherichia coli; Female; Graft vs Host Disease; Intestines; Lactobacillus; Leukopenia; Lymphocytes; Male; Pseudomonas aeruginosa; Rodent Diseases; Rodentia; Staphylococcus; Streptococcus; Sulfaguanidine; Sulfathiazoles; Tetracycline; Thymectomy

Topics: Animals; Benzene; Cyclophosphamide; Dermatitis, Contact; Dinitrophenols; Edema; Erythema; Guinea Pigs; Immunodiffusion; Leukopenia; Lymphocytes; Promethazine; Proteins; Skin; Tetracycline; Tissue Extracts

Topics: Agranulocytosis; Eosinophilia; Humans; Leukopenia; Male; Middle Aged; Tetracycline

Topics: Arteries; Blood Pressure; Body Temperature; Heart Rate; Humans; Insect Vectors; Leukocyte Count; Leukopenia; Phthiraptera; Relapsing Fever; Respiration; Spirochaeta; Tetracycline

Topics: Aged; Agranulocytosis; Anti-Bacterial Agents; Bacteroides; Brucella; Chloramphenicol; Complement System Proteins; Endotoxins; Erythromycin; Hodgkin Disease; Humans; Leukemia; Leukopenia; Lymphadenitis; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Multiple Myeloma; Neoplasms; Penicillins; Primary Myelofibrosis; Properdin; Research; Sarcoma; Streptomycin; Tetracycline

Topics: Adolescent; Aerosols; Anti-Bacterial Agents; Candidiasis; Child; Chloramphenicol; Drug Therapy; Erythromycin; Follow-Up Studies; Humans; Infant; Kanamycin; Leukopenia; Methicillin; Neomycin; Novobiocin; Oxygen Inhalation Therapy; Penicillins; Pneumonia; Pneumonia, Staphylococcal; Radiography, Thoracic; Staphylococcal Infections; Tetracycline; Toxicology

Topics: Bronchial Neoplasms; Carcinoma, Bronchogenic; Cyclophosphamide; Geriatrics; Leukopenia; Lung Neoplasms; Nitrogen Mustard Compounds; Prednisolone; Tetracycline; Toxicology; Urethane