tetracycline and Leg-Ulcer

In an open trial 102 ulcera cruris of chronic venous genesis were treated locally with both Ulcrux Powder and Ointment in 54 female and 48 male patients over a period of 30 days. A positive result was obtained as to the shrinking of the wound area, the diminution of the substance defect, the development of granulations and the tendency towards epithelialisation. The influence on the cleansing of the wounds and on traumatic pain was also very favourable. Due to the rapid cleaning of the ulcera from necrotic films and to the good healing up tendency the therapeutic result was considered good to excellent with 81 patients (79,4%). Local side effects did not occur; the compatibility was also considered good in all cases. These test results prove that the combined treatment of chronic venous ulcera cruris with Ulcrux Ointment and Powder has real therapeutic advantages and seems to be superior to the traditional local forms of treatment.

Topics: Acetates; Adult; Aged; Allantoin; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Female; Heparin; Humans; Leg Ulcer; Male; Middle Aged; Ointments; Pantothenic Acid; Polyethylene Glycols; Powders; Tetracycline

Livedo vasculopathy (LV) is a chronic cutaneous disorder characterised by recurrent, painful ulceration ending in stellate scars. We have conducted a retrospective study of clinical features and treatment response of LV in 24 Chinese patients. LV occurred more frequently in women (male:female ratio  1:3). The peak age at onset of disease ranged from 14 to 20 years, younger than previously published data. 87.5% of the patients (21/24) showed significant summer exacerbation with ulcer formation. Out of 24 patients tested, 14 (58.3%) had positive antiphospholipid antibodies. Ten out of 14 patients (71.4%) were tested to be hypersensitive to multivalent insect antigens. Combinative anti-inflammatory therapy with steroids, tetracycline and Tripterygium glycosides plus antiplatelet/profibrinolytic drugs promoted quick healing of ulcer and reduce recurrence. The younger age of disease presentation and significant summer exacerbation are 2 novel clinical features observed in this study. These findings suggest that apart from procoagulation other risk factors may contribute significantly to the pathogenesis of LV. Although antiplatelet/profibrinolytic drugs are deemed as a first line therapy for LV, anti-inflammatory medications such as steroids, tetracycline and Tripterygium glycosides, from our experiences, are indispensable, especially for acute, ulcerative stage of disease.

Topics: Adolescent; Adult; Age Distribution; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antibodies, Antiphospholipid; Asian People; Biopsy; China; Female; Fibrinolytic Agents; Humans; Hypersensitivity; Insect Bites and Stings; Leg Ulcer; Livedo Reticularis; Male; Phytotherapy; Platelet Aggregation Inhibitors; Prednisone; Retrospective Studies; Seasons; Sex Distribution; Skin; Tetracycline; Tripterygium; Young Adult

Topics: Bandages; Humans; Hydrocortisone; Iatrogenic Disease; Leg Dermatoses; Leg Ulcer; Neomycin; Tetracycline

Topics: Diabetes Complications; Foot; Gangrene; Humans; Leg; Leg Ulcer; Necrosis; Tetracycline

Topics: Accidents, Occupational; Allergens; Female; Humans; Leg Injuries; Leg Ulcer; Middle Aged; Tetracycline

Topics: Adult; Female; Humans; Hydrocortisone; Leg Ulcer; Male; Oxytetracycline; Tetracycline