tetracycline and Laryngeal-Diseases

Dyspnea is a fairly common complaint during pregnancy. However, if one excludes allergic nasal congestion of pregnancy, upper airway obstruction is a distinctly uncommon cause of dyspnea in the pregnant patient. Three cases of laryngeal rhinoscleroma in pregnant women requiring tracheostomy for airway management are reported. All three delivered healthy infants vaginally. Postpartum, two of the three were successfully decannulated, while the third became pregnant again before decannulation was accomplished. Treatment options and a review of the literature are presented.

Topics: Adolescent; Adult; Airway Obstruction; Combined Modality Therapy; Female; Humans; Infant, Newborn; Laryngeal Diseases; Pregnancy; Pregnancy Complications; Rhinoscleroma; Tetracycline; Tracheostomy

An unusual case of nasal and laryngeal scleroma is presented. Laryngeal scleroma should be included in the differential diagnosis of obstructing lesions of the supraglottic airway. The immunoperoxidase staining method is useful in establishing the diagnosis in cases of equivocal culture and histopathologic appearance. It can further be used as an objective test to determine the effectiveness and duration of antibiotic therapy.

Topics: Adolescent; Humans; Immunoenzyme Techniques; Laryngeal Diseases; Male; Rhinoscleroma; Tetracycline

During a three-year-period, 1971-73 inclusive, haemophili isolated from 96 children with severe infections, of whom 73 had meningitis and 19 acute epiglottitis, were serotyped and tested for sensitivity to antibacterial drugs. All strains were identified as Haemophilus influezae type b, and were sensitive to ampicillin, chloramphenicol, and trimethoprim. However, 3 isolates--from a boy aged 11 months and a girl aged 1 year with meningitis, and a girl aged 2 years with epiglottitis--were highly resistant to tetracycline, with a median minimal inhibitory concentration of 50 mug tetracycline hydrochloride per ml (resistance ratio greater than or equal to 50). Resistance was also demonstrated to doxycycline, oxytetracycline, and rolitetracycline and, in one strain, to minocycline. No evidence was obtained that the resistant organisms were capable of inactivating tetracyclines.

Topics: Acute Disease; Anti-Bacterial Agents; Child, Preschool; Drug Resistance, Microbial; Epiglottis; Female; Haemophilus Infections; Haemophilus influenzae; Humans; Infant; Laryngeal Diseases; Male; Meningitis, Haemophilus; Microbial Sensitivity Tests; Serotyping; Tetracycline

Topics: Bronchitis; Cephalothin; Child; Child, Preschool; Chloramphenicol; Empyema; Epiglottis; Erythromycin; Escherichia coli; Haemophilus Infections; Haemophilus influenzae; Histoplasma; Humans; Infant; Klebsiella; Laryngeal Diseases; Methicillin; Mycobacterium tuberculosis; Otitis Media; Penicillins; Pneumonia; Pseudomonas; Respiratory Tract Infections; Sinusitis; Staphylococcus; Streptococcus pneumoniae; Streptococcus pyogenes; Streptomycin; Tetracycline

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Chronic Disease; Humans; Influenza, Human; Laryngeal Diseases; Laryngeal Neoplasms; Otitis Media; Otolaryngology; Penicillins; Sinusitis; Streptomycin; Sulfonamides; Tetracycline; Toxicology